WO2017167201A1 - 膏摩器 - Google Patents

膏摩器 Download PDF

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Publication number
WO2017167201A1
WO2017167201A1 PCT/CN2017/078613 CN2017078613W WO2017167201A1 WO 2017167201 A1 WO2017167201 A1 WO 2017167201A1 CN 2017078613 W CN2017078613 W CN 2017078613W WO 2017167201 A1 WO2017167201 A1 WO 2017167201A1
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WO
WIPO (PCT)
Prior art keywords
friction
rpm
drug
speed
friction head
Prior art date
Application number
PCT/CN2017/078613
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English (en)
French (fr)
Inventor
李复生
李安
杜静
杨晓梅
Original Assignee
李复生
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Publication of WO2017167201A1 publication Critical patent/WO2017167201A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H7/00—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H7/00—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for
    • A61H7/002—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for by rubbing or brushing
    • A61H7/004—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for by rubbing or brushing power-driven, e.g. electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H7/00—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for
    • A61H7/007—Kneading
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention belongs to a medical device, and more specifically relates to a medical device that combines massage and external treatment to treat diseases.
  • the preparation of the towel is to immerse the cockroach in the medicinal juice, or to apply the drug to the cloth.
  • Cream and scraping put a layer of dipping sauce on the treatment site, which can protect the skin and produce medicine. It is suitable for children, the elderly and the infirm, as well as high fever, central nervous system infection, convulsions, certain skin. Sick patient.
  • Cream can treat hundreds of diseases such as internal and external, women, children, ENT, etc., regardless of the disease in the table, Sanjiao, viscera, meridians can be applied, than the single use of massage and drug external application is superior, after thousands of years without decline.
  • the master of the cream master was in the monograph of the external treatment.
  • the effect of the creamy therapy was clearly pointed out: “In the method of transportation and drug treatment, the drug is ready, no ineffective.
  • the prior art mostly uses the plastering tool to perform the creaming, and the traditional plastering tool is commonly used for the spoon and the iron spoon.
  • the spoon in the plastering tool is similar in shape to the scraping tool, such as a smooth spoon and a spoon. It can penetrate deep into the soft tissue of the human body and is easy to use.
  • the scraper is processed into a rectangular shape with rounded corners. The common feature of the spoon and the scraper is the blunt light on the upper part of the tool.
  • the lower part of the tool is a rectangular plate-shaped body. It can squeeze the deep soft parts of the body surface to push the cymbal.
  • the rectangular squeegee is blunt and smooth, and the lower part of the squeegee is square.
  • the upper part of the rectangular convex head of the semi-circular friction head is a rib-like shape, an acute-angle cutting shape, and other triangular shapes, trapezoidal plane shapes, etc., but none of the convex lower parts
  • the body, in contact with the soft tissue of the human body, can not support the upper part of the protrusion to press the affected part to perform deep-pressing pressing.
  • the friction heat generation efficiency is high in the shallow layer.
  • the object of the present invention is to reduce the rotational speed of the friction head, the heat generation temperature is not high, the surface of the friction head lacks a height, and the mechanical extrusion impact force is insufficient, resulting in low efficiency of the cream and friction treatment.
  • Transdermal drug delivery treatment is limited by mechanical and physical conditions and can only be the status of adjuvant therapy.
  • the invention can convert the physical thermal motion into the technical principle of chemical movement according to the "firewood fire", and increase the friction head rotation speed from 1200 rpm to 4000 rpm, so that the skin heating temperature is raised from 50 ° C to The limit is 70 ° C; and the lower square of the friction head is added to increase the height of the protrusion to reduce the compression area and increase the compression strength, so that the mechanical extrusion impact force generated by the friction head during high-speed rotation is significantly improved.
  • the extremely short sputum concentrates, and the rapid production of high heat makes the stratum corneum soften the gap, and pushes the drug molecules through the stratum corneum into the subcutaneous tissue.
  • the invention overcomes the deficiencies of the prior art, significantly improves the therapeutic efficiency of mechanical physiotherapy-based creams, and eliminates the limitation of mechanical physical conditions on transdermal administration, and increases the dose of transdermal drugs in transdermal administration.
  • Therapeutic effect is rapid, and it becomes a direct treatment of chemotherapeutic treatment. Therefore, the symmetry unity between the mechanical physical cream treatment and the chemical transdermal administration treatment promotes the overall effect, thereby achieving the purpose of significantly improving the overall efficacy of the cream.
  • a paste which According to the principle of "drilling wood fire", it consists of a casing, a motor, a bit-shaped semi-circular friction head, a fixed sleeve, a medicated cloth, a paste, and a transdermal drug delivery.
  • the treatment is characterized in that: the motor is fixed in the casing, and the motor drives the bit-shaped semi-circular friction head to rotate at a high speed, and rubs against the medicinal cloth which is fixed on the casing by the bit-shaped semi-circular friction head, and the pressing impact force generated by the friction And heat can be transmitted to the skin through the medicated cloth for cream and transdermal drug treatment; the handle of the case is filled with the cream and the transdermal drug is administered, and the paste is low and medium temperature.
  • the gear speed regulation and heat regulation control, the transdermal drug delivery is the high-speed high-heat four-speed speed regulation and heat regulation control;
  • the bit-shaped semi-circular friction head has a blunt rounded upper part and a lower part of the protrusion.
  • the bit-shaped semi-circular friction head has a rectangular protrusion which is arranged in a "human" shape.
  • the protrusion has the characteristics of an extruded scraping bit.
  • the high-speed rotation around the center can produce a fire-fighting effect.
  • the pressure of the ⁇ ⁇ ⁇ control speed, the pressure of the paste is 1-3 kg / cm 2 , 400 rpm in 1 step and 800 rpm in 2 steps; Cm, 2nd gear 800 rpm and 3 1200 rpm, the cream is controlled by the skin temperature in the warm range of 37_50 °C.
  • the drug is a proprietary Chinese medicine and a chemical with a molecular weight of 1000 or less.
  • Transdermal administration is performed after transdermal administration, 1600 rpm in 1st gear and 2200 rpm in 2nd gear, pressure is 0.2kg/cm2, and the skin temperature is controlled within 50_65°C.
  • the transdermal administration is controlled to shut down after 1 minute and 2 steps of high-speed rotation for 3 minutes; the transdermal administration is 3 times per minute, 3000 rpm and 4 speeds per minute, 4000 rpm.
  • the pressure is 0.1 kg/cm 2
  • the skin temperature is controlled within the high temperature range of 65-70 ° C.
  • the transdermal drug is applied to polymer chemicals and traditional Chinese medicines with a molecular weight of 5,000 or more.
  • the transdermal administration controls the 3rd and 4th speeds. Turn off after 1 minute of rotation.
  • the bit-shaped semi-circular friction head has a rectangular protrusion that can be "one" and "
  • the shape of the drill bit is arranged.
  • the lower part of the bit-shaped semi-circular friction head can be trapezoidal.
  • the rotation of the motor is a brushless direct rotation of the motor to drive the planetary gear to rotate.
  • Four drill-shaped semi-circular friction heads are fixed on the four planetary gear shafts.
  • the number of semi-circular friction heads in the casing is in the range of 2 _50.
  • the external thread at the front end of the casing is matched with the internal thread of the fixed sleeve to fix the medicinal cloth. Tightening and loosening the fixing sleeve.
  • the medicated cloth is coated with a topical medicine, and the external medicine is made into an ointment, a paste, a powder, a washing agent, a wine agent and an oil agent according to the condition and the nature of the drug.
  • Frictional heat is known to people in prehistoric times, because they may have discovered friction and fire in 100,000 years ago, and they used friction to warm the frozen limbs earlier. And gradually found that the use of branches or "drugs" as a fuel for local burning and warm stimulation, can eliminate pain and swelling, thus forming a moxibustion method and hot ironing method.
  • the high-speed rotational friction of 2500 rpm can produce a burning heat of 90 ° C or higher, since the highest heat resistance of human skin is 70 ° C. / sec, to eliminate the lubrication of the liquid, the isolation of the medicated cloth, the frictional resistance to reduce the speed and other cooling factors (about 20 ° C), so the speed does not increase the temperature, and the high-speed rotation of the friction must be slow around the center of the way, Can not stay fixed in the local position.
  • the brushless direct rotation motor suitable for high speed rotation and low noise is determined to cause cauterization.
  • the high-heat speed and the high-speed high-heat control speed regulation are fixed, and continue to use the original low-speed low-temperature and medium-speed medium-temperature rotation, so that the therapeutic function and scope of the present invention are significantly improved. High and increased.
  • the present invention uses a motor to drive a high-speed rotational friction of a bit-shaped semi-circular friction head, and fixes the upper portion of the drill-like semi-circular friction head and the lower portion of the protrusion to Integral, thereby reducing the stress area and increasing the extrusion strength, moving the surface of the skin covered by the medicated cloth, and achieving the heat of the wood within 5 seconds. (At 100 ° C or above, the skin heat limit is 70. °C / sec, suitable for mobile treatment)
  • the drugs including traditional Chinese medicine and chemical drugs coated on the medicated cloth are quickly absorbed into the skin under the friction and fire collision.
  • the invention combines mechanical work, heat energy transfer and chemical action into a whole to concentrate in a very short daytime, which significantly improves the creaming effect.
  • the finger cream has a large area of force, low compression strength, and few action points.
  • the rotational speed of the finger is 120-200 rpm, which is more than 10 times the speed of the present invention, and the efficiency is low, and Long lasting and small range of action.
  • the moxibustion method in traditional medicine is an external treatment method that uses flammable materials and drugs to burn, smoke and apply the affected area, and through warm stimulation and chemical stimulation, to treat and care.
  • Hot iron is a treatment method in which the drug and the auxiliary material are applied to the affected part after heat treatment.
  • Acupuncture is a kind of mechanical stimulation, with information transmission function, no energy conversion and mechanical work, moxibustion and hot iron can carry out energy conversion, combined with acupuncture to form acupuncture method, needle ironing method, significantly improve the curative effect .
  • the treatment process of the present invention itself is a physical form of transformation by mechanical work into frictional heat generation, which generates high-intensity crushing impact and fire-burning effect by high-speed rotation, and converts physical motion into chemical motion through combustion. It has the functions of mechanical, physical and chemical interactions, which can significantly improve the medical effect, and the operation is simple and the scope is wider than traditional therapy and existing technology.
  • Frictional heat generation converts mechanical motion into physical motion, heat causes combustion, and friction and fire transforms physical motion into chemical motion.
  • the transdermal drug treatment of cream and drug massage is a tribochemical action. It is an important branch of force chemistry and physical chemistry. It studies the chemical and physicochemical changes caused by substances under the action of mechanical energy. Friction chemistry is usually a thermal-excited chemical reaction process. Adhesion and material transfer are the main phenomena in friction and wear.
  • Friction and fire extraction is the oldest example of human use of "frictional chemistry”. Mechanical energy (including friction and shock) is used to stimulate chemical reactions. For example, in the prehistoric period, the use of meteorites to take fire, detonator detonation is a typical "friction chemical” process.
  • Friction is the mechanical energy release and conversion that occurs when mixed with a collision, resulting in an increase in the entropy of the entire system and a series of irreversible processes such as physical and chemical changes. Modern science defines frictional collisions as: "The forces that concentrate in the extremely short sacs.” ("Rubber", Science Press, August 1978, 11th edition, p. 24). Generally, physical and chemical processes such as phase transformation, decomposition, merging, and luminescence generated by strong mechanical action are attributed to the conversion of mechanical energy into thermal energy. The temperature effect, friction, impact and other processes can cause the object to be activated. It was thought to be related to the thermal activation caused by the conversion of mechanical energy into thermal energy.
  • the high-speed rotating friction body can reach a higher temperature on the surface. It has been reported to have measured up to 1300K).
  • the systematic research work shows that due to the lack of mechanical shear stress, some chemical changes have not been realized in some cases in the thermal reaction. It is difficult to observe the complex "friction” by the mechanism of "friction heat generation”.
  • the chemistry phenomenon makes a comprehensive and satisfactory explanation. Therefore, there are two common physical models for the interpretation of the "frictional chemistry” process in modern times.
  • One is the "hot spot model” based on “friction heat generation” and the other is called “deformation model”. It is considered that mechanical energy is The main cause of the "tribochemical” process of solids.
  • Human life movement is a form of overall advanced movement composed of mechanical, physical, and chemical primary movement forms.
  • the laws of the primary movement form are different from the expressions that play a role in the inanimate natural system. They are subject to more The advanced law of life movement acts externally.
  • Holistic treatment can have a direct effect and a significant effect, with some treatments producing indirect effects and limited efficacy. Therefore, unlike the prior art mechanical, physical, and chemical primary motion forms, the present invention follows the law of life movement, and treats the disease by using advanced exercise treatment methods that promote the overall effect of mechanical, physical, and chemical interactions, simultaneously, according to The strength of mechanical, physical, and chemical factors in human life movements determines the strength of mechanical, physical, and chemical treatments in overall treatment.
  • transdermal drug delivery depends not only on the quality and quantity of the therapeutic factors, but also on the combination of treatment factors, ie, holistic treatment. Different from the physical therapy of medicated cream and supplemented by drug therapy, transdermal drug delivery is based on chemotherapeutic therapy and supplemented by physical therapy. Transdermal administration is given to Western medicine by changing the dosage form and route of administration. The new method of use, breaking the "drug structure" is the only concept that determines the efficacy of the drug. Practice has proved that when the local blood concentration is increased by one time, the curative effect is increased by 10 times, and the drug is prevented from passing through the liver and stomach and reducing the dosage, so that the treatment is safer and more effective.
  • the invention is based on the characteristics of increasing the friction head rotation speed, which is the main factor of increasing the frictional friction collision force and the temperature rise, and designing and manufacturing the "transdermal drug high-speed high-heat four-speed speed regulation and heat regulation control", using the motor Drive the bit-shaped semi-circular friction head to rotate at a high speed, and carry out large-area moving friction on the skin surface covered by the medicated cloth.
  • the friction and fire function allows the skin temperature to reach 70 °C within 3 seconds, which makes the skin stratum corneum soften the gap.
  • the high-strength extrusion collision force pushes the drug molecules through the stratum corneum into the subcutaneous tissue.
  • the priming cream is used as the main treatment for physical physiotherapy and chemotherapeutic treatment, which becomes a form of advanced exercise therapy. Therefore, through the direct action of the cream on the whole disease, the purpose of significantly improving the therapeutic effect is achieved.
  • the stratum corneum of the skin is the main barrier for transdermal absorption of drugs.
  • the traditional drug penetration enhancer mainly reduces the skin barrier effect, but the therapeutic effect is not satisfactory.
  • Japanese scholar Ye Junjunyi said in the “Design and Development of New Drug Preparations” (China Medical Science and Technology Press): “The shortcomings of the existing transdermal drug delivery are mainly: Dermal administration is limited by physical properties. 2 It is difficult to achieve quick results.
  • the skin of the human skin tissue has a sensing device for receiving mechanical stimulation, warm stimulation, and chemical stimulation.
  • the drill-like semi-circular friction head used in the present invention has a rectangular protrusion fixed by a friction head at a high speed. , squeezing drug molecules into the skin and achieving the various temperatures required for transdermal administration. The higher the rotational speed, the higher the temperature. Due to various cooling factors, such as chemical lubrication, frictional resistance, plasmonic temperature, and patient's physical difference, the specific temperature required depends on the specific conditions.
  • the vibration method is a combination of pressure stimulation and wave transmission.
  • the center of the drill-like semi-circular friction head is equipped with a physiotherapy vibrator. It belongs to the prior art and uses high frequency vibration. The vibration energy is deep into the affected body. Conduction, converted into the internal energy of the body, the faster the frequency, the deeper the conduction, which helps to promote blood circulation and drug absorption.
  • the phase change of the stratum corneum of human skin occurs between 42_70 ° C, the skin temperature rises by 10 ° C, the drug penetration increases by 1.4_3 times, and the transdermal dose and transdermal administration area become 1: 1 is proportional.
  • the movement speed is 4 cm/sec, the high heat 70 °C, the local residence time is 0.2 seconds, and the skin is not damaged.
  • the transdermal drug-administered area is more than the existing one. Technology is increased by 10 times.
  • the ideal physical and chemical properties of the prior art transdermal drug are: molecular weight below 1000, melting point below 85 ° C, solubility in water and mineral oil are preferably above 1 mg / ml, the pH of the saturated aqueous solution is 5-9.
  • the molecular motion increases and the high heat movement occurs, and the molecular weight of the drug is less than 5,000, which can increase the range of application drugs for transdermal administration.
  • Wu Shiji a master of the Qing Dynasty, said: "The Capricorn must be as strong as it is to make it hot, but it is quick-acting.”
  • the existing physical transdermal administration is generally more than 10 minutes.
  • the invention combines the high-strength extrusion frictional impact force generated by the high-speed rotation of the bit-shaped semicircular friction head with the high heat temperature according to the principle of "drilling wood fire".
  • topical transdermal drug delivery can be completed in a very short period of 10 seconds to 30 seconds.
  • the cream is based on frictional heat generation, and is a treatment method mainly based on physical massage and drug permeation.
  • the invention has the advantages of improving the rotational speed and improving the shape of the friction head protrusion.
  • the function of wiping the fire can transform the physiotherapy-based cream into a transdermal drug treatment mainly composed of chemical drugs and physiotherapy.
  • transdermal administration is not limited by physical properties, and the transdermal administration dose can be increased and the quick-acting effect can be achieved, thereby overcoming the deficiencies in the prior art for transdermal administration, with significant progress.
  • oral drugs are difficult to locate differences, but cream and transdermal drug delivery can be targeted therapy, transdermal drug delivery treatment target is deep in the body or local tissue, and oral administration is different.
  • Preparation of topical liquid Chinese medicine is prepared by infusion or decoction according to the existing oral and external ointment. It can be added into the corresponding contact agent and penetration aid. It can be applied evenly after mixing. It can also be used in Chinese medicine, such as blood circulation. Active oil, safflower oil, etc. in phlegm. The nitroglycerin and Xiaoxintong in western medicine can be changed to skin administration.
  • the anticancer drugs cyclophosphamide and vincristine are added to the corresponding coupling agents according to their characteristics, and they can be applied evenly with stirring.
  • fat-soluble drugs are added to lanolin to form ointments or cold creams; water-soluble drugs are dissolved in water.
  • the massage technique mainly has four kinds of pressure, friction, vibration force and tension.
  • One technique is usually a kind of force, and the other includes other forces; for example, the friction method is mainly friction.
  • the friction method is mainly friction.
  • it is mainly pressure, and both have friction.
  • different parts and different patients need to apply different pressures. For example, when pressing the back of the waist, use a large force to make the stimulation deep into the body.
  • the stimulation intensity is the pressure area, the small finger method, the pressure area, the medium, the fish area, the pressure area, and the large palm root.
  • the smaller the surface area of the body the greater the intensity of the technique and the stronger the stimulation to the patient.
  • the greater the intensity of the stress stimulus the deeper the affected part.
  • the pressing method is a massage method in which pressure stimulation and internal friction work together.
  • the main purpose of compression and swaying is to drive the movement of the subcutaneous tissue of the affected area to cause internal friction, and the swaying speed can directly affect the body.
  • the amount of friction The main difference between the rubbing method and the pressing method is as follows: 1 During the rubbing process, the patient's affected area is not compressed. 2 friction does not drive or does not basically move the subcutaneous tissue.
  • the edge of the spoon is smooth and easy to use, and the spoon edge is highly supported by the spoon wall to ensure the smooth edge of the spoon is in the cream During the process, the strength of the force-receiving area is not increased; the edge of the scraping plate is blunt-rounded and smooth, and the edge of the scraping plate is supported by a rectangular plate-like height to ensure that the force-reducing area is not increased during the scraping process.
  • the above-mentioned tools belong to the translational friction type massage tool, and the friction heat generation effect is better, but there is a deficiency in the pressing downward action similar to the drill wood fire; the hand-held spoon and the scraper are partially moved, only about 120 revolutions per minute. , and achieve a local deep level heating effect, the experiment proves that the turbulent speed should be about 1000 rev / min, which is impossible in manual cymbal.
  • the traditional friction tools have a small application range, such as the cervical vertebrae and the lumbar vertebrae. Because of the prominent bones (especially the seventh cervical vertebrae are prominent), it is more difficult to apply the spoon and the scraper to make the paste and rub, and the action points are less.
  • the swaying frequency is low, and the four drill-shaped semi-circular friction heads in the invention are arranged in a square shape with a space in the middle, and two friction heads on each of the left and right sides, which are very suitable for pressing and deepening the cervical vertebrae and the lumbar vertebrae. Heating, the treatment effect is better than traditional technology.
  • the various convex shapes in the semi-circular friction head of the prior art are a rib shape, an acute angle cutting shape, a triangular shape, a trapezoidal plane shape, etc., and none of the convex lower square body supports, in the pair Human soft tissue After massage, you can't support the upper part of the protrusion to press the affected part to perform deep pressing. Due to the lack of protrusion height, the soft tissue portion is in contact with the semi-circular friction head, and the area of the force is large, so that the affected area cannot be pressed, thereby reducing the pressing strength.
  • the semicircular friction head of the prior art has a diameter of 1.5 cm and a height of 1.5 cm, and has a convex rib shape, a height of the upper portion of the cutting protrusion of 0.2 cm_0.4 cm, and a diameter of 0.2 cm_0.4 cm;
  • the lower part has a height of 0.2 cm _ 0.5 PCT and a width of 0.2 cm _ 0.5 cm.
  • Other values are the same as in the prior art, and the semicircular friction head and the convex shape and the squeeze friction function and the appearance of the drill bit in the prior art.
  • the shape extrusion friction function is similar, called a drill-like semi-circular friction head.
  • the squeegee is driven by a brushless direct rotation motor to rotate four planetary gears equipped with a semi-circular friction head to generate the bit movement for the paste, which has high friction heat generation. High strength and easy to use features.
  • the friction head of the upper portion of the rib-like projections lacks the convexity of the lower square body, and the height of the protrusion is insufficient, and the pressing function is not provided.
  • the soft woven enamel contact area is significantly increased, and is limited by the influence of the medicated cloth and the lubrication of the medicinal juice.
  • the high-speed rotation ⁇ has low frictional resistance and low heat production, and cannot reach the required working temperature of 60-70 °C. Since the friction ⁇ is covered by the soft tissue, the pressure area is too large, resulting in a decrease in the friction strength.
  • the force of the upper part of the bulge and the semi-circular friction head can be increased; for example, the rib shape is actually a semi-circular entity,
  • the large force area does not compress the affected area to increase the extrusion strength.
  • the invention overcomes the shortcomings of the prior art corresponding measures, the blunt round shape of the upper part of the protrusion is integrated with the square of the lower part of the protrusion, the lower part of the protrusion has the height required for pressing the cymbal, and the area of the blunt rounded area of the convex part is small. Increasing the extrusion strength does not increase the force area, and can significantly increase the friction strength and the strength of the extrusion press.
  • the height of the upper portion of the semi-circular friction head and the lower portion of the protrusion are in the range of 0.4 cm to 0.8 cm, and the soft tissue can only interact with the blunt-shaped convex portion of the semi-circular friction head, and the stress area is small and the pressure intensity is large. It can play the role of pressure-based and friction-assisted massage.
  • shallow-level friction therapy and deep-level rubbing treatment such as shallow-level friction method, 1000 rpm, pressure 0.5 kg _1 kg/cm 2 , friction
  • the heat-generating temperature can reach 50 ° C in 5 seconds, by delivering heat energy and promoting transdermal administration, meeting the need for the cream to slowly move at a rate of 3 cm / sec.
  • the deep pressing speed is 400 rpm, the pressure is 1 kg _3 kg/cm 2 , the pressing force can reach the muscle level through the subcutaneous tissue, and the internal friction of the subcutaneous tissue and muscles of the affected area is generated, and the rigid muscle is pressed.
  • the fixing sleeve and the casing fixing the medicinal cloth are mutually squeezing and squeezing, and under the action of the vibration and friction of the motor running, the medicinal cloth is easy to fall off during the squeezing process.
  • the invention adopts a safe and firm fixing sleeve and a threaded connection of the casing to fix the medicinal cloth, thereby solving the problem that the medicinal cloth is easy to fall off in the prior art.
  • 1 is a front view of a paste.
  • FIG. 2 is a view of the direction of the paste of FIG. 1.
  • FIG. 3 is a B-direction view of the paste device shown in FIG. 1.
  • FIG. 4 is an integrated view of the convex upper portion of the drill-like semicircular friction head of the plastering device shown in FIG. 1 and the convex lower square shape.
  • FIG. 5 is a schematic diagram of a technical index of a paste.
  • 1 is a casing
  • 2 is a motor
  • 3 is a drill-like semi-circular friction head
  • 4 is a fixed sleeve
  • 5 is a medicated cloth
  • 6 is a paste
  • 7 is a paste
  • Figure 2 is a view of the A-direction of the paste
  • Figure 3 is a view of the B-direction of the paste
  • Figure 4 is the lower part of the bump-shaped semi-circular friction head and the lower part of the protrusion
  • Figure 1 is a one-piece view
  • Figure 5 is a schematic diagram of the technical indicators of the paste.
  • the paste of the present invention is realized by the following technical measures: a paste, which is based on the principle of "firewood fire", by a casing, a motor, a bit-shaped semi-circular friction head, a fixed sleeve, The medicated cloth, the cream, the transdermal administration, and the transdermal administration are used for the treatment of the cream and transdermal administration.
  • the features are as follows: The casing (1) is fixed inside the motor (2), and the motor (2) drives the drill bit.
  • the semi-circular friction head (3) rotates at a high speed, and rubs against the blister (5) which is fixed on the casing (1), and the squeezing impact force and heat energy are transmitted through the friction.
  • the protrusions have the characteristics of squeezed scraping bits.
  • the high-speed rotation around the center can produce a fire-fighting effect.
  • Mosquito ⁇ ( (6) control the speed, the pressure of the squeezing pressure is 1-3 kg / cm 2 , the first speed 400 rev / min and the second gear 800 rev / min, the pressure of the mop push is 0.5_1 Kg/cm2, 800 rpm in 2nd gear and 1200 rpm in 3nd gear.
  • the temperature of the skin is controlled in the warm range of 37_50°C.
  • the drug is a proprietary Chinese medicine and a chemical with a molecular weight of 1000 or less.
  • Transdermal drug delivery After transdermal administration, 1 1600 rpm / 2 2200 rpm, pressure is 0.2 kg / cm 2, the skin temperature is controlled within 50_65 ° C high heat range Transdermal drug application is a chemical drug and traditional Chinese medicine with a molecular weight of 5,000 or less.
  • Transdermal administration (7) control shutdown after 3 minutes of high-speed rotation; transdermal administration ⁇ 3 files 3000 rpm/min and 4 steps 4000 rpm , the pressure is 0.1 kg / cm 2 , the skin temperature is controlled within the range of 6 5 to 70 ° C high heat, transdermal drug application of molecular weight 5000 or more polymer chemical drugs and traditional Chinese medicine, through Skin administration (7) Controls the high speed rotation for 1 minute and then shuts down.
  • Drill-like semi-circular friction head (3) Rectangular projections can be "one" and "
  • Rotation is a brushless direct rotation of the motor to drive the planetary gears to rotate.
  • Four drill-shaped semi-circular friction heads (3) are fixed on the four planetary gear shafts.
  • the number of the semi-circular friction heads (3) mounted in the casing (1) is in the range of 2 to 50 .
  • Enclosure d) The external thread at the front end is matched with the internal thread of the fixing sleeve ( 4 ) to fix the medicated cloth (
  • fixing sleeve (4) The exterior is engraved with a plurality of vertical stripes to facilitate the tightening and loosening of the fixing sleeve by hand (4).
  • the medicated cloth (5) is coated with a topical medicine, and the external medicine is made into an ointment, a paste, a powder, a washing agent, a wine, and an oil according to the condition and the nature of the drug.
  • the patient is treated with transdermal drug delivery, the local treatment is no more than 1 minute, and the larger area is not more than 3 minutes, and the patient operates or is under the guidance of a doctor.
  • the treatment is once a day, 15 times per treatment.
  • the invention is applied to the treatment of patients with low back pain, the patient's waist muscles are stiff and the activity is limited. After repeated artificial massage and external application of drugs, the effect is not obvious, and the doctor uses a plaster to treat the patient, and the medicine used is a proprietary Chinese medicine. Active oil, after treatment, the patient said that the waist is hot and painful. The next day, he was treated again. He said that the waist was nearly one day after the fever, and the effect was obvious. The patient recovered after 5 treatments.

Abstract

一种膏摩器，由机壳（1）、电机（2）、钻头状半圆摩擦头（3）、固定套（4）、药布（5）、膏摩开关（6）、透皮给药开关（7）组成，采用改进的摩擦头部凸起形状和由电机（2）带动摩擦头（3）高速转动，摩擦头（3）与覆盖皮肤的药布（5）相摩擦产生高强度挤压冲击力和高热温度，通过综合作用进行膏摩和摩擦透皮给药，从而显著提高了膏摩整体疗效，并且克服了现有人工膏摩中存在的劳动强度大和手部易损伤等不足。

Description

说明书 发明名称：膏摩器
技术领域
[0001] 本发明属于医疗器械， 更详细地讲是属于按摩、 药物外治结合为一体治疗疾病 的医疗器械。
背景技术
[0002] "摩擦生热、 钻木取火"是人类历史上第一项伟大发明， 它使人们的生活方式发 生了根本性的变革， 并为按摩、 热熨、 灸法和摩擦给药的产生应用提供了重要 条件， 从而减少疾病延长人类的寿命。 祖国传统医学中的药物按摩， 古称膏摩 ， 是明清以前中医药外治的主要方法， 它是将中药膏剂作为按摩介质涂在施治 部位， 然后用膏摩工具或按摩手法贴附在体表做直线或环旋移动， 按摩的同吋 皮肤迅速吸收药物， 通过按摩与药物外治相结合的方法， 达到治疗疾病和预防 保健的目的。 长沙马王堆 3号汉墓出土的 《养生方》 中提到了一种最富特色的按 摩工具一 "药巾"， 药巾的制作是将帛浸渍在药汁中， 或把药物涂在布上， 阴干 后制成药巾， 用以按摩身体的部位， 在先秦用药巾按摩身体以补养元气进行养 生保健， 是相当普遍的。 膏摩和刮痧吋在治疗部位放一层浸药汁薄布， 既可保 护皮肤、 又可产生药效， 适用于儿童、 年老体弱者， 以及高热、 中枢神经系统 感染、 抽搐、 某些皮肤病患者。 膏摩可治疗内、 外、 妇、 儿、 五官科等数百种 疾病， 无论病在表里、 三焦、 脏腑、 经络皆可应用， 比单用按摩和药物外敷疗 效为优， 历经千年而不衰。 清代膏摩大师吴师机在外治专著 《理瀹骈文》 一书 中对膏摩疗法效果明确指出： "运手法与药物治疗中， 以药力到为候， 无不效者
， 实足以代替针、 灸、 按摩三法。 "
[0003] 由于人工手法进行膏摩会对医者手部产生药液浸泡摩擦损伤， 现有技术大多采 用膏摩工具进行膏摩， 传统膏摩工具常用的是汤匙与铁匙。 （参见 《药摩》 主 编于晓强、 科学出版社、 2014年 4月第一版中第 9页） 膏摩工具中的汤匙与刮痧 工具一刮板的形状相似， 如汤匙边缘光滑、 匙体可深入人体软组织， 使用方 便； 刮板加工成长方形， 四角钝圆。 汤匙与刮板的共同特点是工具上部钝圆光 滑， 可对体表浅层次摩擦并产生热能， 工具下部为长方形板状体， 可对体表深 层次柔软部位进行挤压推动按揉， 长方形刮板上部钝圆光滑， 刮板下部呈方形
， 适用于全身各部位治疗需要。 在现有技术 《癌症疾病治疗器》 ZL20061006998 7·8中， 半圆摩擦头部长方形凸起上部是筋状、 锐角切削状， 还有其它三角状、 梯形平面状等， 但均没有凸起下部方形体， 在与人体软组织接触相互作用吋， 不能支撑凸起上部压紧患处部位进行深层次挤压按揉， 当膏摩治疗器在低压力 高速转动吋， 对浅层次部位摩擦生热效率高， 在高压力低速转动吋， 对深层次 部位挤压按揉效率低， 不能满足对全身各部位进行膏摩治疗的需要。 在现代医 学透皮给药治疗中， 主要是采用药物渗透皮肤促进剂， 缺乏机械、 物理促进作 用， 不能形成机械、 物理、 化学相互促进整体作用的透皮给药治疗方式， 受机 械、 物理因素制约， 透皮吸收给药量较小， 治疗效果并不显著。
技术问题
[0004] 本发明的目的， 在于针对现有技术中存在着摩擦头转速低、 生热温度不高， 摩 擦头表面凸起缺乏高度、 机械挤压冲击力小的不足， 导致膏摩治疗效率低， 透 皮给药治疗受机械、 物理条件限制只能是辅助治疗的现状。 本发明根据"钻木取 火"可以将物理热运动转化为化学运动的技术原理， 将摩擦头转速从最高 1200转 / 分钟增加到 4000转 /分钟， 使对皮肤发热温度从 50°C提高到极限 70°C; 并增加了 摩擦头凸起下部方形体， 以提高凸起高度减少受力面积增大挤压强度， 使摩擦 头在高速转动中产生的机械挤压冲击力显著提高， 可以在极短促的吋间内集中 作力， 迅速产生高热使皮肤角质层变软间隙加大， 并同吋推动药物分子穿过角 质层进入皮下组织。 本发明克服了现有技术的不足， 显著提高了机械物理治疗 为主的膏摩治疗效率， 并消除了机械物理条件对透皮给药的限制， 使透皮给药 治疗中透皮药物剂量增加、 疗效迅速， 成为可以直接作用的化学治疗为主治疗 方式。 从而通过机械物理膏摩治疗与化学透皮给药治疗之间对称统一、 相互促 进整体作用， 达到显著提高膏摩整体疗效的发明目的。
问题的解决方案
技术解决方案
[0005] 为了达到上述发明目的， 本发明是通过以下技术方案进行的： 一种膏摩器， 它 是根据 "钻木取火"技术原理， 由机壳、 电机、 钻头状半圆摩擦头、 固定套、 药布 、 膏摩幵关、 透皮给药幵关组成， 进行膏摩和透皮给药治疗， 其特征在于： 机 壳内固定按装电机， 电机带动钻头状半圆摩擦头高速转动， 与复盖钻头状半圆 摩擦头固定在机壳上的药布进行摩擦， 摩擦产生的挤压冲击力和热能透过药布 传导到皮肤进行膏摩和透皮给药治疗； 机壳手把部按装有膏摩幵关、 透皮给药 幵关， 膏摩幵关是低中速温热 3档调速调热控制幵关， 透皮给药幵关是高速高热 4档调速调热定吋控制幵关； 钻头状半圆摩擦头部长方形凸起上部呈钝圆角型， 凸起下部呈方形， 凸起上部与凸起下部平齐固定为一体。 钻头状半圆摩擦头部 长方形凸起呈 "人"字型排列， 凸起具有挤压刮削钻头特点， 绕中心高速转动挤压 摩擦吋可产生钻木取火效果。 膏摩幵关控制转速， 进行膏摩按揉吋压力是 1-3公 斤 /平方厘米， 1档每分钟 400转和 2档每分钟 800转； 膏摩平推吋压力是 0.5-1公斤 / 平方厘米， 2档每分钟 800转和 3档每分钟 1200转， 膏摩对皮肤温度控制在 37_50 °C温热范围内， 使用药物是外用中成药和分子量 1000以下化学药物。 透皮给药 幵关在进行透皮给药吋， 1档每分钟 1600转和 2档每分钟 2200转， 压力是 0.2公斤 / 平方厘米， 对皮肤温度控制在 50_65°C高热范围内， 透皮给药应用分子量 5000以 下化学药物和中药， 透皮给药幵关控制 1档和 2档高速转动 3分钟后关机； 透皮给 药 3档每分钟转速 3000转和 4档每分钟转速 4000转， 压力是 0.1公斤 /平方厘米， 对 皮肤温度控制在 65— 70°C高热范围内， 透皮给药应用分子量 5000以上高分子化学 药物和中药， 透皮给药幵关控制 3档和 4档高速转动 1分钟后关机。 钻头状半圆摩 擦头长方形凸起可以呈"一"字型和"
翁'
"字型钻头状排列， 钻头状半圆摩擦头部长方形凸起下部可以呈梯形。 电机转动 是无刷直接转动电机带动行星齿轮转动， 四个行星齿轮轴上固定有四个钻头状 半圆摩擦头。 机壳内按装钻头状半圆摩擦头数量是在 2个_50个范围内。 机壳前 端外螺纹与固定套内螺纹相配合固定药布， 固定套外部刻有多条竖纹便于用手 转紧和转松固定套。 药布上涂有外用药物， 外用药物根据病情需要和药物的性 质， 制成软膏剂、 糊剂、 散剂、 洗搽剂、 酒剂和油剂。
发明的有益效果 有益效果
[0006] 为了充分公幵发明创造， 本发明对透皮给药与按摩相关治疗原理技术， 进行详 细说明。
[0007] 一、 "摩擦生热、 钻木取火"是灸法、 热熨、 砭石、 按摩等治疗方法产生和应用 的重要条件
[0008] 摩擦生热在实践上是史前的人就已经知道的了， 因为他们也许在 10万年前就发 现了摩擦取火， 而且他们在更早就用摩擦来使冻冷了的肢体温暖， 并渐渐发现 用树枝或"药物"作燃料对局部进行烧灼温热刺激， 可以消除疼痛和肿疡， 这样便 形成了灸法和热熨法。
[0009] 在 《现代科技导论》 （刘大椿等著， 中国人民大学出版社， 2009年 7月第 2版 26 页） 中记载 "1798年， 美国物理学家伦福德 （1753— 1814) 发现钻炮膛所用的钻 头越钝， 所产生的热量越多。 对实验结果的分析表明， 热只能来源于钻头运动 。 "同吋， 我们在 1997年 11月 25日样机实验中发现： 在本发明样机没有对体表进 行压力的情况下， 当转速为 2500转 /分钟吋幵机 5秒钟后复盖钻头状半圆摩擦头的 干药布幵始冒烟燃烧， 从而证明本发明样机产生了钻木取火的效果和具备钻木 取火功能。 因此可以确定： 采用钻头状半圆摩擦头在轻微压力下提高转速是升 温的主要因素， 2500转 /分钟高速转动摩擦可产生 90°C以上烧灼性高热， 由于人 体皮肤最高耐热度为 70°C/秒， 排除药液润滑、 药布隔离、 摩擦阻力降低转速等 降温因素 （约降低 20°C左右） ， 所以转速不再提高升温， 并且在高速转动膏摩吋 必须采用缓慢绕中心移动方式， 不能停留固定在局部体位。
[0010] 按摩既有信息的传递， 又有能量的转换和机械作功， 按摩中常用的是按和摩两 种手法， 按法是单纯的向下用力， 即所谓"按而留之"， 摩法则是在体表作环行摩 擦， 属平动的范围。 本发明的特点是： 根据"摩擦生热， 钻木取火"的原理， 与传 统膏摩工具、 刮痧工具、 现有技术半圆摩擦头凸起的特点， 研制了类似钻头形 状、 在半圆摩擦头部固定有"人"字型排列的长方形凸起， 凸起上部呈钝圆角型， 凸起下部呈方形的摩擦头； 采用适合高速转动、 噪音小的无刷直接转动电机， 确定可产生烧灼性高热的转速和按装高速高热控制调速定吋幵关， 并继续采用 原有的低速低温和中速中温转动， 从而使本发明的治疗功能和范围得到显著提 高和加大。
[0011] 二、 钻木取火技术原理在膏摩、 灸法、 热熨中的应用
[0012] 1、 本发明根据传统膏摩疗法的治疗经验和现代科学中摩擦碰撞定义， 采用电 机带动钻头状半圆摩擦头高速转动摩擦， 将钻头状半圆摩擦头凸起上部与凸起 下部固定为一体， 从而减少受力面积加大挤压强度， 对药布复盖的皮肤表面进 行移动摩擦， 5秒钟内达到钻木取火热度， （在 100°C以上， 皮肤受热极限吋间为 70°C/秒， 适合进行移动治疗） 药布上所涂药物 （包括中药和化学药物） 在摩擦 取火和挤压碰撞下进入皮肤被迅速吸收。 本发明将机械作功、 热能传递、 化学 作用结合成整体在极短促的吋间内集中作用， 显著提高了膏摩效果。 而传统人 工膏摩治疗中， 手指膏摩受力面积大、 挤压强度低， 作用点少， 手指按揉转动 速度为 120_200转 /分钟， 与本发明转速相差 10倍以上， 效率低， 并且不能持久 和作用范围小。
[0013] 2、 传统医学中的灸法， 是采用易燃材料和药物， 以烧灼、 熏熨和贴敷患处， 通过温热性刺激和化学性刺激， 进行治疗和保健的一种外治方法。 热熨是采用 药物和辅料， 经过加热处理后敷于患部的一种治疗方法。 针刺是一种机械刺激 ， 具有信息传递功能， 并无能量转换和机械作功， 灸法与热熨均可进行能量转 换， 与针刺相结合形成针灸法、 针熨法， 显著提高了疗效。 在现有技术中， 日 本 Kuartomi和 Miyauchi申请的 US专禾 1」4,747,841， 利用艾灸的原理发明了中药经皮 给药的新剂型； 其特点是在发火室内有控制地燃烧， 温度维持 65°C， 皮肤温度 40 ~45°C， 可维持 6小吋， 此温度可促进中药进入皮肤。 上述传统疗法与现有技术 ， 主要是依靠烧灼性高热进行治疗， 但是由于缺乏机械作功， 不能产生整体作 用， 使透皮药物剂量受到限制， 并且作用范围较小， 导致疗效有限。 本发明治 疗过程本身就是一种通过机械作功转化为摩擦生热的物理作用形式， 通过高速 转动产生高强度挤压冲击和钻木取火烧灼性效果， 通过燃烧将物理运动转化为 化学运动， 具备了机械、 物理、 化学相互结合整体作用的功能， 可以显著提高 医疗效果， 并且操作简单作用范围广泛优于传统疗法和现有技术。
[0014] 三、 钻木取火技术原理在透皮给药治疗中的应用
[0015] 1、 摩擦生热、 钻木取火的科学技术原理 [0016] 人类的祖先利用摩擦生热原理， 发明了钻木取火 （又称摩擦取火） ， 从摩擦生 热到摩擦取火， 是不同运动形式之间相互转化的一种普遍现象。 摩擦生热将机 械运动转化为物理运动， 热引起燃烧， 摩擦取火又将物理运动转化为化学运动 。 膏摩、 药物按摩的透皮给药治疗， 是一种摩擦化学作用， 是力化学、 物理化 学的重要分支， 它研究物质在机械能作用下所引起的化学的和物理化学的变化 。 摩擦化学通常属于热激发化学反应过程， 粘着与材料转移是摩擦磨损中的主 要现象； 摩擦取火是人类运用 "摩擦化学"规律最古老的例子， 利用机械能 （包括 摩擦和冲击） 来激发化学反应， 如在史前用燧石取火， 雷管引爆则是典型的 "摩 擦化学"过程。
[0017] 摩擦是与碰撞相拌发生的机械能释放和转换， 从而导致整个系统熵的增加以及 一系列的物理、 化学变化等不可逆过程。 现代科学将摩擦碰撞定义为： "在极短 促的吋间内集中作用的力"。 ( 《摩擦》 、 科学出版社、 1978年 8月第 11版 24页） 通常人们对于在强机械作用下产生的物理化学过程， 如相变、 分解、 化合、 发 光等均归于机械能转化为热能后的温度效应， 摩擦、 撞击等过程可使物体活化 的原因， 曾认为是与机械能转化为热能而引起的热激活有关， 如高速转动的摩 擦体在其表面上的局部可以达到较高的温度 （据报道曾测出高达 1300K) 。 但是 系统的研究工作表明， 由于缺乏机械切应力作用， 有些化学变化是某些物质在 热反应中迄今未能实现的， 只用"摩擦生热"的机制很难对所观察到的复杂"摩擦 化学"现象做出全面而满意的解释。 因此， 近代关于"摩擦化学"过程的解释有两 种常用的物理模型， 一种是 "摩擦生热"为基础的"热点模型"， 另一种称为"变形 模型"， 它认为机械能是使固体发生 "摩擦化学"过程的主要原因。
[0018] 2、 摩擦生热、 钻木取火原理在现有技术中的应用
[0019] 传统膏摩治疗中， 人工按压揉动是机械作用， 平动摩擦生热将机械能转化为热 育 ， 并促进所涂药物膏剂透皮吸收， 是一种符合生命运动形式的整体性质作用 力。 但是人工按摩效率太低， 人工按揉与平动往返摩擦每分钟为 100_200次， 热能转换温度低， 摩擦生热温度为 45°C以下， 不能产生透皮给药化学运动过程所 需的高机械强度与烧灼性物理高热， 疗效并不显著。 由于传统膏摩对操作者手 部易产生损伤， 目前推广应用并不广泛。 药物外敷、 膏药、 针灸、 热熨均缺乏 机械作功产生的机械能， 不能产生机械物理化学相结合整体作用的直接疗效。
[0020] 3、 摩擦生热、 钻木取火原理在透皮给药治疗过程中的应用
[0021] 人体生命运动是由机械、 物理、 化学初级运动形式组成的整体高级运动形式， 在生命运动中初级运动形式的规律与在无生命自然系统中起作用的表现形式不 同， 它们服从于更高级的生命运动规律， 以整体方式对外作用。 整体治疗可以 产生直接作用和显著疗效， 部分治疗产生间接作用和有限疗效。 所以， 与现有 技术中机械、 物理、 化学初级运动形式单独治疗不同， 本发明遵循生命运动规 律， 通过采用机械、 物理、 化学相互促进整体作用的高级运动治疗方式来治疗 疾病， 同吋， 根据人体生命运动中机械、 物理、 化学等因素的作用力度， 确定 整体治疗中机械、 物理、 化学治疗力度的大小。 透皮给药治疗技术作用的提高 ， 不仅取决于治疗因素的质量和数量， 而且取决于治疗因素的组合方式即整体 治疗。 与膏摩物理治疗为主、 药物治疗为辅的方式不同， 透皮给药是以化学治 疗为主、 物理治疗为辅的方式， 透皮给药通过改变药物剂型和给药途径， 赋予 西药以崭新的使用方法， 打破了 "药物结构"是唯一决定药效的观念。 实践证明， 当局部血药浓度提高 1倍吋， 疗效提高 10倍， 并避免了药物首过肝胃和减少用药 量， 使治疗更加安全有效。
[0022] 本发明根据提高摩擦头转速是加大挤压摩擦碰撞力度和升温的主要因素特点， 设计制造了"透皮给药高速高热 4档调速调热控制定吋幵关"， 采用电机带动钻头 状半圆摩擦头高速转动方式， 对药布复盖的皮肤表面进行大面积移动摩擦， 摩 擦取火功能让皮肤温度在 3秒钟内达到 70°C， 使皮肤角质层变软间隙加大， 高强 度挤压碰撞力同吋推动药物分子穿过角质层进入皮下组织。 在 10秒 _30秒内完 成透皮给药化学为主治疗后， 启动膏摩幵关进行物理为主治疗， 使机械物理治 疗与化学治疗两种方式相互转换整体作用， 成为高级运动治疗形式， 从而通过 膏摩整体对疾病直接作用治疗， 达到显著提高疗效的目的。
[0023] 四、 膏摩器功能
[0024] 皮肤角质层是药物透皮吸收的主要屏障， 传统的药物渗透促进剂主要是降低皮 肤屏障作用， 但治疗效果并不理想。 日本学者野吕俊一在 《药物新制剂的设计 与幵发》 （中国医药科技出版社） 中认为： "现有透皮给药的不足主要是： ①透 皮给药受物理性质的限质。 ②很难达到速效。 ③不能用大量药物治疗"。 现有技 术采用的离子导入法、 电致孔法和超声波透皮给药物理技术及各种声、 光、 电 、 磁促渗技术， 与上述传统的药物渗透促进剂， 由于缺乏机械作功高速转动挤 压摩擦和高热效应， 导致不能对提高透皮给药疗效产生显著的作用。 在实践中 ， 外用药物无论是霜剂、 水剂还是油膏剂， 都必须借助于摩擦发挥和提高疗效 ， 单纯依靠渗透促进剂、 热能传递， 疗效受到限制。
[0025] 1、 人体皮肤组织中毛细血管壁上存有接受机械刺激、 温热刺激、 化学刺激的 感受装置， 本发明所用的钻头状半圆摩擦头部固定有长方形凸起可以通过摩擦 头高速转动， 挤压药物分子进入皮肤， 并达到进行透皮给药所需要的各种温度 。 转速越高产生温度越高， 由于治疗吋存在各种降温因素， 如药液润滑、 摩擦 阻力大小、 药布隔温、 患者体质差导等， 具体所需温度根据具体情况选择合适 转速。 振法是一种压强刺激和波的传递相结合的治疗方法， 本发明钻头状半圆 摩擦头排列中心按装有理疗振动器， 属现有技术， 采用高频率振动， 振动能量 向患处机体深处传导， 转化为机体的内能， 频率越快传导的程度就越深， 有助 于促进血液循环和药物吸收。
[0026] 2、 人体皮肤角质层的相变发生在 42_70°C之间， 皮肤温度上升 10°C， 药物穿 透性提高 1.4_3倍， 透皮给药剂量与透皮给药面积成 1:1正比。 当用膏摩器进行 大面积移动透皮给药治疗吋， 移动速度为 4厘米 /秒， 高热 70°C吋局部停留吋间为 0.2秒， 不会损伤皮肤， 透皮给药面积比现有技术提高 10倍。 现有技术透皮给药 的药物理想理化性质条件是： 分子量 1000以下， 熔点低于 85°C， 在水和矿物油中 的溶解度最好均在 lmg/ml以上， 饱合水溶液的 PH值在 5— 9。 在本发明钻木取火 过程中分子运动加大出现高热运动， 药物分子量 5000以下均可应用， 从而加大 了透皮给药的应用药物种类范围。 清代外治大师吴师机认为： "摩吋须极力， 令 作热， 乃速效"。 现有物理透皮给药吋间一般在 10分钟以上， 本发明根据"钻木取 火"技术原理， 将钻头状半圆摩擦头高速转动产生的高强度挤压摩擦冲击力和高 热温度结合为一体整体作用， 可以在极短促的 10秒 _30秒内完成局部透皮给药 治疗。 现有技术中膏摩是以摩擦生热为基础， 是物理按摩为主、 药物渗透为辅 的一种治疗方式， 本发明通过提高转速升温和改进摩擦头凸起形状， 具备了摩 擦取火的功能， 可以将物理治疗为主的膏摩转化为化学药物治疗为主、 物理治 疗为辅的透皮给药治疗。 本发明中透皮给药不受物理性质的限制， 可以加大透 皮给药剂量并达到速效， 从而克服了透皮给药现有技术中的不足， 具有显著的 进步。
[0027] 3、 口服药物难以定位区别， 但膏摩与透皮给药可以做到定位治疗， 透皮给药 的治疗目标是在全身或局部组织深部， 与口服给药有差别。 外用药液配制： 中 药根据现有的口服类、 外用药膏类药方制成浸液或煎剂， 加入相应的接触剂、 助渗剂中， 搅拌均匀即可应用， 也可使用中成药， 如活血化瘀类中的活络油、 红花油等。 西药中的硝酸甘油、 消心痛均可改为皮肤给药， 抗癌药物环磷酰胺 、 长春新碱按其特性分别加入相应的耦合剂中， 搅拌均匀即可应用。 如脂溶性 药物加入羊毛脂中， 配制成油膏或冷霜； 水溶性药物溶于水中等。
[0028] 4、 本发明技术指标
[0029] 具体详细说明参见 《膏摩器技术指标示意图》 ， 说明书附图 5。
[0030] 五、 膏摩器按摩作用原理与膏摩发展前景
[0031] 1、 按摩手法作用力主要有压力、 摩擦力、 振动力和张力四种， 一种手法往往 是一种作用力为主， 同吋包括其它作用力； 如摩擦法是以摩擦为主， 同吋兼有 压力， 按揉法是以压力为主， 同吋兼有摩擦力。 在按摩中， 不同的部位及不同 患者的情况， 需要施加不同的压力， 如在按揉腰背部吋， 要用较大的力使刺激 深透到机体内部。 当压力一定吋， 刺激强度为压力面积小指揉法>压力面积中等 鱼际揉 >压力面积大掌根揉。 体表受力面积越小， 手法强度越大， 对患者的刺激 也越强。 压力刺激强度越大， 牵动的部位就越深。
[0032] 按揉法是一种以压强刺激和内摩擦共同作用的按摩手法， 压紧揉动的主要目的 是为了带动患处皮下组织的运动， 使之产生内摩擦， 揉动速度可以直接影响体 内摩擦力的大小。 摩擦法与按揉法的主要区别是： ①摩擦过程中并不压紧吸定患 者患处。 ②摩擦吋不带动或是基本不带动皮下组织的运动。 这就是说， 在按揉中 医者所做的功几乎全部转化为患处皮下组织热运动的内能， 而在摩擦法中医者 所做的功几乎全部转化为治疗部位表面热运动的内能， 摩擦法使表面皮肤温度 升高， 然后通过热传导向皮下组织渗透， 由于肌肉组织是热的不良导体， 所以 这种升温将比通过按揉内摩擦直接升温慢的多。
[0033] 2、 清代著名外治宗师吴师机在 《理瀹骈文》 中说道： "外治之理即内治之理， 外治之药亦即内治之药。 治虽在外， 无殊治内也"， 外治可"与内治并行， 而能补 内治之逮"。 从医疗的起源来看， 应当说外治远早于内治， 既便在 《内经》 吋代 亦主张内外并治， 在我国唐代以前医疗上外治与内治并重， 宋代以后医家受理 学思想影响偏重内治， 外治一道乃渐黜。 后世医家大多沿着内病汤、 丸、 散剂 内服药的治疗思路， 而忽略了外法方法， 逐渐形成了只有外科等疾病方用外治 的重内轻外的治疗思想， 使外治疗法理论体系的建立迟于内治千余年。 （参见 《当代中药外治临床大全》 贾一江等主编、 中国中医药出版社， 1991年 4月第 1 版第 4页） 膏摩疗法作为清代以前中医药物外治的主要方法， 数千年来有着丰富 的临床经验和疗效， 有着巨大的发展空间和潜力， 将传统膏摩工具、 刮痧板、 药巾与现代科学技术相结合， 操作使用方便， 可以显著提高膏摩疗效和扩大治 疗范围， 从而发扬光大中医药外治法、 造福患者。
[0034] 六、 本发明与现有技术产品对比
[0035] 1、 与传统膏摩工具 （药摩工具） 、 刮痧工具中的汤匙、 刮痧板相比较， 汤匙 边缘光滑， 使用方便， 汤匙边缘后有汤匙板壁高度支撑， 保证汤匙光滑边缘在 膏摩过程中不增加受力面积降低强度； 刮痧板边缘是钝圆角并光滑， 刮痧板边 缘后是长方形板状高度支撑， 保证刮痧过程中不增加受力面积降低强度。 上述 工具属于平动摩擦类按摩工具， 摩擦生热效果比较好， 但在按压揉动向下作用 类似钻木取火方面， 存在不足； 手持汤匙、 刮板在局部揉动吋， 每分钟仅 120转 左右， 而达到局部深层次加热效果， 实验证明揉动速度应当在 1000转 /分钟左右 ， 这在人工按揉来说是不可能的。 另外， 传统摩擦类工具应用范围小， 如颈椎 和腰椎两侧， 由于有骨头突出 （特别是第七颈椎突出明显） ， 应用汤匙、 刮板 进行膏摩按压揉动难度较大， 作用点少， 揉动频率低， 而本发明中的四个钻头 状半圆摩擦头成四方型排列， 中间有空间， 左右两边各有两个摩擦头， 非常适 合对颈椎、 腰椎两侧进行按压揉动和深层次加热， 治疗效果优于传统技术。
[0036] 2、 现有技术半圆摩擦头中的各种凸起形状， 如凸起上部是筋状、 锐角切削状 、 三角状、 梯形平面状等， 均没有凸起下部方形体支撑， 在对人体软组织部位 按摩吋， 不能支撑凸起上部压紧患处部位进行深层次按揉。 由于缺乏凸起高度 导致软组织部位与半圆摩擦头部接触受力面积较大， 不能压紧患处， 因而降低 了按压强度。 现有技术中的半圆摩擦头部圆直径为 1.5厘米， 高度为 1.5厘米， 凸 起筋状、 切削状凸起上部高度为 0.2厘米 _0.4厘米， 直径为 0.2厘米 _0.4厘米； 本发明中凸起下部高度为 0.2厘米 _0.5厘为， 宽度为 0.2厘米 _0.5厘米， 其它数 值与现有技术相同， 其半圆摩擦头与凸起的外观形状与挤压摩擦功能与现有技 术中钻头的外观形状挤压摩擦功能相似， 称为钻头状半圆摩擦头。 现有技术中 的各种形状摩擦头凸起在临床治疗使用中， 患者、 医者普遍反映摩擦生热效果 明显， 包括透皮给药效果， 但按压强度不足， 特别是在进行腰背部按压揉动按 摩中。 本发明通过增加凸起下部方形结构， 增加了凸起高度， 减少了受力面积 ， 显著提高了按压揉动强度， 克服了现有技术的不足。
[0037] 3、 本发明根据膏摩和药摩工具汤匙、 刮痧板的特点， 钝角钻头摩擦产热量高 和热来源于钻头运动的原理， 设计的钻头状半圆摩擦头长方形凸起， 凸起上部 是钝圆角状， 凸起下部是方形体， 膏摩器由无刷直接转动电机带动四个按装有 半圆摩擦头的行星齿轮转动， 产生钻头运动进行膏摩， 具有摩擦生热量高、 按 揉力度高和使用方便的特点。 现有技术中的筋状凸起上部等摩擦头， 由于缺乏 凸起下部方形体支撑， 凸起高度不足， 不具备挤压功能。 在压迫人体弹性软组 织吋接触面积显著增大， 并受药布包复、 膏摩药汁润滑影响限制， 高速转动吋 摩擦阻力小、 产热量低， 不能达到所需 60-70°C工作温度。 由于摩擦吋被软组织 复盖压力面积过大， 导致摩擦强度降低， 如果加大按压力度只能增加凸起上部 与半圆摩擦头受力面积； 如凸起筋状实际上是类似半圆型实体， 增大受力面积 并不能压紧患处加大挤压强度。 本发明克服了现有技相应措施不足， 凸起上部 钝圆角状与凸起下部方形结合为一体， 凸起下部具有挤压按揉所需高度， 凸起 上部钝圆角受力面积小， 加大挤压强度按揉吋受力面积并不增加， 可以压紧患 处显著提高摩擦强度、 挤压按揉强度。
[0038] 4、 在半圆摩擦头压力下， 人体肌肉软组织部位下陷深度在 0.3厘米一 0.6厘米范 围内， 现有技术半圆摩擦头凸起高度为 0.2厘米 _0.5厘米， 弹性软组织可以复盖 半圆摩擦头凸起和半圆摩擦头大部分面积， 导致体表受力面积大压力强度小， 只能起到摩擦为主、 压力为辅的作用。 而本发明中半圆摩擦头凸起上部与凸起 下部相加高度为 0.4厘米 _0.8厘米范围内， 软组织只能与半圆摩擦头钝圆角状凸 起上部相互作用， 受力面积小压力强度大， 可以起到压力为主、 摩擦为辅的按 摩作用。 通过调整压力和转速， 可以分别进行浅层次的摩擦法治疗和深层次的 按揉法治疗， 如浅层次摩擦法吋转速 1000转 /分钟， 压力 0.5公斤 _1公斤 /平方厘 米吋， 摩擦生热温度可在 5秒钟内达到 50°C， 通过输送热能和促进透皮给药， 满 足膏摩以 3厘米 /秒速度缓慢移动治疗需要。 深层次按揉吋转速 400转 /分钟， 压力 1公斤 _3公斤 /平方厘米， 按压力度可透过皮下组织达到肌肉层次， 带动患处皮 下组织和肌肉的运动产生内摩擦， 对僵硬肌肉进行按揉放松， 改善微循环、 活 血化瘀和促进透皮药物吸收； 而现有技术摩擦头凸起由于缺乏凸起下部高度支 撑， 与弹性软组织相互作用吋挤压强度小， 无论怎样调整压力和转速， 都不能 进行深层次按揉。
[0039] 5、 在现有的手持按摩器中， 是采用有刷电机和齿轮减速装置， 存在着噪音大 、 耗电量高、 结构复杂等不足， 本发明采用无刷直接转动电机， 具有噪音小、 耗电量低、 没有齿轮减速装置结构简单等特点， 克服了现有技术的不足。
[0040] 6、 在现有的手持按摩器中， 固定套与机壳固定药布是依靠双方相互挤压配合 ， 在电机运转震动和摩擦力作用下， 膏摩过程中存在着药布易脱落不安全因素 ， 本发明采用安全牢固的固定套与机壳螺纹联接固定药布， 解决了现有技术中 药布易脱落的不足。
[0041] 在本发明的精神有原则之内所作的任何修改、 等同替换和改进等， 均应包含在 本发明的保护范围之内。
对附图的简要说明
附图说明
[0042] 图 1是膏摩器主视图。
[0043] 图 2是图 1所示膏摩器的 A向视图。
[0044] 图 3是图 1所示膏摩器的 B向视图。
[0045] 图 4是图 1所示膏摩器中钻头状半圆摩擦头的凸起上部钝圆角状和凸起下部方形 体一体视图。 [0046] 图 5是膏摩器技术指标示意图。
[0047] 具体实施方式：
[0048] 本发明的图 1所示膏摩器中： 1是机壳， 2是电机， 3是钻头状半圆摩擦头， 4是 固定套， 5是药布， 6是膏摩幵关， 7是透皮给药幵关； 图 2是膏摩器的 A向视图； 图 3是膏摩器的 B向视图； 图 4是钻头状半圆摩擦头凸起上部钝圆角状和凸起下部 方形体一体视图； 图 5是膏摩器技术指标示意图。
本发明的实施方式
[0049] 本发明的膏摩器是通过以下技术措施实现的： 一种膏摩器， 它是根据"钻木取 火"技术原理， 由机壳、 电机、 钻头状半圆摩擦头、 固定套、 药布、 膏摩幵关、 透皮给药幵关组成， 进行膏摩和透皮给药治疗， 其特征在于： 机壳 （1) 内固定 按装电机 （2) ， 电机 （2) 带动钻头状半圆摩擦头 （3) 高速转动， 与复盖钻头 状半圆摩擦头 （3) 固定在机壳 （1) 上的药布 （5) 进行摩擦， 摩擦产生的挤压 冲击力和热能透过药布 （5) 传导到皮肤进行膏摩和透皮给药治疗； 机壳 （1) 手把部按装有膏摩幵关 （6) 、 透皮给药幵关 （7) ， 膏摩幵关 （6) 是低中速温 热 3档调速调热控制幵关， 透皮给药幵关 （7) 是高速高热 4档调速调热定吋控制 幵关； 钻头状半圆摩擦头 （3) 部长方形凸起上部呈钝圆角型， 凸起下部呈方形 ， 凸起上部与凸起下部平齐固定为一体。 钻头状半圆摩擦头 （3) 长方形凸起呈" 人"字型排列， 凸起具有挤压刮削钻头特点， 绕中心高速转动挤压摩擦吋可产生 钻木取火效果。 膏摩幵关 （6) 控制转速， 进行膏摩按揉吋压力是 1一 3公斤 /平方 厘米， 1档转速 400转 /分钟和 2档 800转 /分钟， 膏摩平推吋压力是 0.5_1公斤 /平方 厘米， 2档 800转 /分钟和 3档 1200转 /分钟， 膏摩对皮肤温度控制在 37_50°C温热 范围内， 使用药物是外用中成药和分子量 1000以下化学药物。 透皮给药幵关 （7 ) 在进行透皮给药吋， 1档 1600转 /分钟和 2档 2200转 /分钟， 压力是 0.2公斤 /平方 厘米， 对皮肤温度控制在 50_65°C高热范围内， 透皮给药应用是分子量 5000以下 化学药物和中药， 透皮给药幵关 （7) 控制高速转动 3分钟后关机； 透皮给药吋 3 档 3000转 /分钟和 4档 4000转 /分钟， 压力是 0.1公斤 /平方厘米， 对皮肤温度控制在 65一 70°C高热范围内， 透皮给药应用分子量 5000以上高分子化学药物和中药， 透 皮给药幵关 （7) 控制高速转动 1分钟后关机。 钻头状半圆摩擦头 （3) 长方形凸 起可以呈"一"字型和"
"字型钻头状排列， 钻头状半圆摩擦头 （3) 部长方形凸起下部可以呈梯形。 电机
(2) 转动是无刷直接转动电机带动行星齿轮转动， 四个行星齿轮轴上固定有四 个钻头状半圆摩擦头 （3) 。 机壳 （1) 内按装钻头状半圆摩擦头 （3) 数量是在 2一 50个范围内。 机壳 d) 前端外螺纹与固定套 （4) 内螺纹相配合固定药布 (
5) ， 固定套 （4) 外部刻有多条竖纹便于用手转紧和转松固定套 （4) 。 药布 （ 5) 上涂有外用药物， 外用药物根据病情需要和药物的性质， 制成软膏剂、 糊剂 、 散剂、 洗搽剂、 酒剂和油剂。
[0050] 治疗方法具体操作步骤如下：
[0051] 1、 患者采用坐位或卧位， 膏摩吋患者手握涂有药液的膏摩器在按摩部位进行 按摩， 采用缓慢移动方式， 局部膏摩吋间不超过 3分钟， 较大面积膏摩吋间不超 过 10分钟， 在专人协助下可进行背部膏摩和全身膏摩。
[0052] 2、 患者进行透皮给药治疗吋， 局部治疗不超过 1分钟， 较大面积治疗不超过 3 分钟， 由医生操作或在医生指导下患者自我操作。
[0053] 3、 治疗为每日一次， 每疗程 15次。
[0054] 本发明的实施例
[0055] 采用本发明对腰痛患者进行治疗， 患者腰部肌肉僵硬、 活动受限， 经多次人工 按摩和药物外敷， 效果均不明显， 医者采用膏摩器对该患者治疗， 所用药物是 中成药活络油， 治疗后患者表示腰部发热痛疼减轻。 第二天再次治疗吋说腰部 发热吋间将近一天， 效果明显， 患者治疗 5次后痊愈。

Claims

权利要求书
[权利要求 1] 一种膏摩器， 它是根据"钻木取火"技术原理， 由机壳、 电机、 钻头状 半圆摩擦头、 固定套、 药布、 膏摩幵关、 透皮给药幵关组成， 进行膏 摩和透皮给药治疗， 其特征在于： 机壳 （1) 内固定按装电机 （2) ， 电机 （2) 带动钻头状半圆摩擦头 （3) 高速转动， 与复盖钻头状半圆 摩擦头 （3) 固定在机壳 （1) 上的药布 （5) 进行摩擦， 摩擦产生的 挤压冲击力和热能透过药布 （5) 传导到皮肤进行膏摩和透皮给药治 疗； 机壳 （1) 手把部按装有膏摩幵关 （6) 、 透皮给药幵关 （7) ， 膏摩幵关 （6) 是低中速温热 3档调速调热控制幵关， 透皮给药幵关 （ 7) 是高速高热 4档调速调热定吋控制幵关； 钻头状半圆摩擦头 （3) 部长方形凸起上部呈钝圆角型， 凸起下部呈方形， 凸起上部与凸起下 部平齐固定为一体。
[权利要求 2] 按照权利要求 1所述的膏摩器， 其特征在于钻头状半圆摩擦头 （3) 长 方形凸起呈"人"字型排列， 凸起具有挤压刮削钻头特点， 绕中心高速 转动挤压摩擦吋可产生钻木取火效果。
[权利要求 3] 按照权利要求 1所述的膏摩器， 其特征在于膏摩幵关 （6) 控制转速， 进行膏摩按揉吋压力是 1_3公斤 /平方厘米， 1档转速 400转 /分钟和 2档 800转 /分钟， 膏摩平推吋压力是 0.5— 1公斤 /平方厘米， 2档 800转 /分钟 和 3档 1200转 /分钟， 膏摩对皮肤温度控制在 37_50°C温热范围内， 使 用药物是外用中成药和分子量 1000以下化学药物。
[权利要求 4] 按照权利要求 1所述的膏摩器， 其特征在于透皮给药幵关 （7) 在进行 透皮给药吋， 1档 1600转 /分钟和 2档 2200转 /分钟， 压力是 0.2公斤 /平方 厘米， 对皮肤温度控制在 50_65°C高热范围内， 透皮给药应用是分子 量 5000以下化学药物和中药， 透皮给药幵关 （7) 控制 1档和 2档高速 转动 3分钟后关机； 透皮给药吋 3档 3000转 /分钟和 4档 4000转 /分钟， 压 力是 0.1公斤 /平方厘米， 对皮肤温度控制在 65_70°C高热范围内， 透 皮给药应用分子量 5000以上高分子化学药物和中药， 透皮给药幵关 ( 7) 控制 3档和 4档高速转动 1分钟后关机。 按照权利要求 1所述的膏摩器， 其特征在于钻头状半圆摩擦头 （3) 长 方形凸起可以呈"一"字型和"
脊
"字型钻头状排列， 钻头状半圆摩擦头 （3) 部长方形凸起下部可以呈 梯形。
按照权利要求 1所述的膏摩器， 其特征在于电机 （2) 转动是无刷直接 转动电机带动行星齿轮转动， 四个行星齿轮轴上固定有四个钻头状半 圆摩擦头 （3) 。
按照权利要求 1所述的膏摩器， 其特征在于机壳 （1) 内按装钻头状半 圆摩擦头 （3) 数量是在 2— 50个范围内。
按照权利要求 1所述的膏摩器， 其特征在于机壳 （1) 前端外螺纹与固 定套 （4) 内螺纹相配合固定药布 （5) ， 固定套 （4) 外部刻有多条 竖纹便于用手转紧和转松固定套 （4) 。
按照权利要求 1所述的膏摩器， 其特征在于药布 （5) 上涂有外用药物 ， 外用药物根据病情需要和药物的性质， 制成软膏剂、 糊剂、 散剂、 洗搽剂、 酒剂和油剂。
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CN105877905A (zh) * 2016-03-30 2016-08-24 李复生 膏摩器
CN106492343A (zh) * 2016-12-08 2017-03-15 李复生 癌转移透皮给药治疗器
CN110841180B (zh) * 2019-11-12 2021-07-09 上海长征医院 定量推注式电动涂药器
CN115671527A (zh) * 2022-07-27 2023-02-03 北京神州汉方医药科技有限公司 基于温度和压力耦合控制的皮肤给药控制装置及给药装置
CN114949577B (zh) * 2022-07-28 2022-11-11 北京神州汉方医药科技有限公司 皮肤给药控制装置

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