WO2017157316A1 - 左心耳封堵器及其输送系统 - Google Patents

左心耳封堵器及其输送系统 Download PDF

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Publication number
WO2017157316A1
WO2017157316A1 PCT/CN2017/076909 CN2017076909W WO2017157316A1 WO 2017157316 A1 WO2017157316 A1 WO 2017157316A1 CN 2017076909 W CN2017076909 W CN 2017076909W WO 2017157316 A1 WO2017157316 A1 WO 2017157316A1
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WIPO (PCT)
Prior art keywords
atrial appendage
left atrial
appendage occluder
hub
delivery system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/CN2017/076909
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English (en)
French (fr)
Inventor
汪振
周毅
姚瑶
李俊菲
罗七一
黄海勇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Microport Medical Group Co Ltd
Original Assignee
Shanghai Microport Medical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201610157997.0A external-priority patent/CN107198552B/zh
Priority claimed from CN201610379161.5A external-priority patent/CN107440760B/zh
Application filed by Shanghai Microport Medical Group Co Ltd filed Critical Shanghai Microport Medical Group Co Ltd
Priority to US16/082,821 priority Critical patent/US11039822B2/en
Priority to EP17765858.0A priority patent/EP3431022A4/en
Publication of WO2017157316A1 publication Critical patent/WO2017157316A1/zh
Anticipated expiration legal-status Critical
Priority to US17/214,432 priority patent/US20210212674A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00579—Barbed implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00632—Occluding a cavity, i.e. closing a blind opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12095—Threaded connection

Definitions

  • the invention relates to the technical field of medical instruments, in particular to a left atrial appendage occluder and a delivery system thereof.
  • Atrial fibrillation is the most common persistent arrhythmia in the clinic.
  • the incidence of atrial fibrillation in the general population is 0.5% to 1.3%.
  • the main hazard of atrial fibrillation is to promote thrombosis. After thrombus detachment, it is easy to cause complications such as stroke and peripheral vascular embolization, and significantly increase morbidity and mortality. Stroke is the most common and most devastating complication of atrial fibrillation. About 15 million people worldwide suffer from stroke each year, 20% to 25% of which are attributed to atrial fibrillation.
  • Anticoagulant therapy is currently the standard method for preventing complications of atrial fibrillation, but anticoagulant therapy has certain limitations. Therefore, it is important to use more effective and safe measures to prevent atrial fibrillation.
  • the method of occlusion of the left atrial appendage is performed by using medical intervention.
  • the commonly used left atrial appendage occluder has a single-body type occluder represented by WATCHMAN and a plug-type left atrial appendage occluder represented by AMPLATZER Cardiac Plug (ACP).
  • the inner-plug type left atrial appendage occluder is a nickel-titanium alloy frame with a self-expanding structure, with fixed barbs around it, and the atrial surface is covered by a porous PTFE membrane, and blood flow can enter and exit the left atrial appendage.
  • the shape of the left atrial appendage is very irregular, and the deformability of the device is limited, and the left atrial appendage cannot be completely blocked, and it is difficult to eliminate the formation of a thrombus in the left atrial appendage due to atrial fibrillation.
  • the structure of the left atrial appendage is different, the depth is different, and there is a multi-cavity structure.
  • the inner-plug type left atrial appendage occlusion device cannot fully adapt to the anatomy of all left atrial appendages, and stable fixation cannot be achieved at the same time.
  • the plug-type left atrial appendage occluder is a double-disc left atrial appendage occlusion device consisting of a butterfly blade and a butterfly cap placed on the left atrial appendage, with the concave waist connected and the butterfly blade placed on the left
  • the auricle prevents the occluder from shifting, and the butterfly cap seals the left atrial appendage.
  • the plug-type left atrial appendage occluder is an integral part of the sealing disc and the fixed disc, and cannot be completely deformed independently. After the child is inserted into the left atrial appendage, when the disc portion is buckled at the mouth of the left atrial appendage, it will be pulled by the plug portion, so that the disc portion cannot fully fit the mouth of the left atrial appendage, and it is difficult to achieve optimal sealing. effect. Due to the limited length adjustment of the plug portion and the disc portion, it is difficult to achieve optimal fixation and blood flow blockage, and the disc structure does not accommodate different left atrial appendage shapes.
  • the present invention provides a left atrial appendage occluder comprising a plurality of support beams distributed on an outer side of a first hub and extending outwardly, the support The beam is separated into a left support beam and a right support beam at a first position, and the left support beam and the right support beam adjacent to the support beam are connected at a second position and extend distally to form a distal end;
  • the middle of the adjacent support beam of the left atrial appendage occluder includes a support rod.
  • the first end of the support rod is connected to the outer side of the first hub, the first end of the support rod extends outward, and is disposed at the third position Open as a second end and a third end.
  • the second end is fixed between the first and second positions of the left support beam, and the third end is fixed to the right support beam Between the first and second positions.
  • the second end and the third end are respectively fixed on two adjacent support beams.
  • the length of the support rod from the first hub to the third position is smaller than the length of the support beam from the first hub to the first position length.
  • the first end, the second end and the third end of the support rod have a “Y” shape.
  • all or part of the support beam includes a barb
  • all or part of the left support beam and the right support beam include a barb
  • the left support beam and the right support formed by the same support beam The distal ends of the beams are connected.
  • the distal end is bent proximally to form an anchor.
  • the length of the distal end of the bending point to the end is greater than the length of the distal connection point to the end.
  • the distal end extends inwardly and forms a second hub.
  • the distal end projects radially to form an anchor.
  • the first hub is coaxial with the second hub.
  • the direction in which the first hub is axially convex is the same as or opposite to the direction in which the second hub is axially convex.
  • the left atrial appendage occluder at least partially covers a biocompatible membrane.
  • the angle between adjacent support beams is 45°.
  • a plurality of support beams are disposed, the support beams are distributed outside the first hub and extend outward, and the support beam is separated into a left support beam at the first position.
  • a right support beam, the left support beam and the right support beam adjacent to the support beam are connected at a second position and extend distally to form a distal end, and a support rod is included in the middle of the adjacent support beam to ensure the left atrial appendage
  • the stability of the occluder does not occur irregular deformation and lateral slip.
  • the support rod in the middle of the adjacent support beam causes the left atrial appendage occluder to form a dense mesh, which can further improve the left atrial appendage.
  • the overall strength of the occluder The self-expanding frame and the anchor of the left atrial appendage occluder provided by the invention are integrally formed, and no additional process steps are required to make the anchor.
  • the anchoring component of the left atrial appendage occluder provided by the invention can not only provide a strong and effective anchoring effect, but also effectively prevent the force generated by the atrial fibrillation from causing the displacement of the occluder, and avoid the excessive anchorage. Piercing tissue.
  • Another object of the present invention is to provide a delivery system for a left atrial appendage occluder to better achieve the sheathing or release of the left atrial appendage occluder.
  • the present invention provides a delivery system for a left atrial appendage occluder for releasing a left atrial appendage occluder, the delivery system comprising a first delivery portion and a second located in the first delivery portion Conveying section;
  • the first delivery portion is for separating or connecting with the first hub of the left atrial appendage occluder
  • the second delivery portion is for separating or connecting with the second hub of the left atrial appendage occluder.
  • the delivery system does not release the left
  • the first hub engages the second hub when the auricle is occluded.
  • the delivery system further includes a sheath tube, the first delivery portion being located inside the sheath tube.
  • the delivery system further includes a limiting device for fixing the first conveying portion and the second conveying portion.
  • the limiting device in the delivery system of the left atrial appendage occluder, includes a clamping portion and a force applying portion, and the clamping portion is partially or completely passed through the first conveying portion.
  • the upper card slot holds the second conveying portion.
  • the delivery system further includes a handle, the handle being located at a proximal end of the first conveying portion and/or the second conveying portion.
  • the handle has a visual indicator thereon.
  • the left atrial appendage occluder comprises a first portion and a second portion; one end of the first portion is connected to the first hub, and the other end is One end of the second portion is connected, and the other end of the second portion is connected to the second hub.
  • the second portion is located in the first portion when the delivery system does not release the left atrial appendage occluder.
  • the first portion and/or the second portion are provided with a plurality of anchors.
  • the distal end of the first hub includes a step, when the first hub is engaged with the second hub, the second The proximal end of the hub is located on the step.
  • the proximal end of the first hub includes a groove, and the distal end of the first delivery portion is located in the groove.
  • the distal end of the first conveying portion has a trumpet shape.
  • the first hub and the second hub pass the external spline internal spline Structural connection or snap-on connection.
  • the first conveying portion and the first hub are connected by a threaded nut structure, an external spline internal spline structure or a snap structure connection and / or the second conveying portion and the second hub are connected by a threaded nut structure connection, an external spline internal spline structure connection or a snap structure.
  • the delivery system includes a first delivery portion and a second delivery portion located within the first delivery portion, the first delivery portion and the left atrial appendage prior to sheathing a first hub connection of the occluder; a second delivery portion coupled to the second hub of the left atrial appendage occluder, whereby the left atrial appendage occluder can be collapsed, and then the left atrial appendage occluder
  • the sheath can be used to avoid the problem that the length of the left atrial appendage occluder is too long in the sheath.
  • the second portion of the left atrial appendage occluder provided with the anchor is first released, at which point the positioning can be repeated until a suitable fixed position is reached, and then the second hub of the left atrial appendage occluder and the first hub are released.
  • the delivery system of the left atrial appendage occluder provided by the present invention can better achieve the sheathing or release of the left atrial appendage occluder.
  • FIG. 1 is a perspective view showing the structure of a left atrial appendage occluder according to Embodiment 1 of the present invention
  • FIG. 2 is a top plan view of a left atrial appendage occluder according to Embodiment 1 of the present invention
  • FIG. 3 is a partially enlarged schematic view showing a left atrial appendage occluder according to Embodiment 1 of the present invention
  • FIG. 4 is a partially enlarged schematic view showing a left atrial appendage occluder according to Embodiment 1 of the present invention
  • Figure 5 is a schematic view showing the state of the left atrial appendage occluder on the left atrial appendage according to the first embodiment of the present invention
  • Figure 6 is a perspective view showing the structure of a left atrial appendage occluder according to a second embodiment of the present invention.
  • Figure 7 is a cross-sectional view showing a left atrial appendage occluder according to a second embodiment of the present invention.
  • Figure 8 is a cross-sectional view showing another left atrial appendage occluder according to a second embodiment of the present invention.
  • Figure 9 is a cross-sectional view showing another left atrial appendage occluder according to a second embodiment of the present invention.
  • Figure 10 is a perspective view showing the structure of a left atrial appendage occluder according to a third embodiment of the present invention.
  • Figure 11 is a cross-sectional view showing a left atrial appendage occluder according to a fourth embodiment of the present invention.
  • FIG. 12 is a schematic structural view of a left atrial appendage occluder delivered by a delivery system of a left atrial appendage occluder according to Embodiment 5 of the present invention
  • FIG. 13 is a schematic structural view of a delivery system of a left atrial appendage occluder according to Embodiment 5 of the present invention.
  • Figure 14 is a schematic view showing the state of the delivery system of the left atrial appendage occluder in the fifth embodiment of the present invention when the left atrial appendage occluder is not released;
  • FIG. 15 is a schematic view showing a state in which a delivery system of a left atrial appendage occluder is released in a portion of a left atrial appendage occluder according to a fifth embodiment of the present invention
  • 16 is a schematic view showing still another state of the delivery system of the left atrial appendage occluder according to the fifth embodiment of the present invention when the left atrial appendage occluder portion is released;
  • Figure 17 is a schematic view showing the state of the delivery system of the left atrial appendage occluder in the fifth embodiment of the present invention when the left atrial appendage occluder is fully released;
  • FIG. 18 is a schematic view showing a state in which a delivery system of a left atrial appendage occluder is anchored to a left atrial appendage according to a fifth embodiment of the present invention
  • FIG. 19 is a schematic structural diagram of a limiting device according to Embodiment 5 of the present invention.
  • Figure 20 is a schematic structural view showing the fixing device of the first conveying portion and the second conveying portion of the limiting device according to the fifth embodiment of the present invention.
  • 21 is a schematic view showing a state in which a delivery system of a left atrial appendage occluder is released in a portion of a left atrial appendage occluder according to a sixth embodiment of the present invention
  • Figure 22 is a schematic view showing the state of the delivery system of the left atrial appendage occluder according to the sixth embodiment of the present invention when the left atrial appendage occluder portion is released;
  • Figure 23 is a schematic view showing the state of the delivery system of the left atrial appendage occluder according to the sixth embodiment of the present invention when the left atrial appendage occluder is fully released;
  • Figure 24 is a schematic view showing the state of the delivery system of the left atrial appendage occluder according to the seventh embodiment of the present invention when the left atrial appendage occluder portion is released;
  • Figure 25 is a schematic view showing the state of the delivery system of the left atrial appendage occluder according to the eighth embodiment of the present invention when the left atrial appendage occluder is fully released;
  • 26 is a schematic view showing another state of the delivery system of the left atrial appendage occluder according to the eighth embodiment of the present invention when the left atrial appendage occluder is fully released;
  • Figure 27 is a schematic view showing another state of the delivery system of the left atrial appendage occluder according to the eighth embodiment of the present invention when the left atrial appendage occluder is fully released;
  • Figure 28 is an external spline structure of an eighth embodiment of the present invention.
  • Figure 29 is an internal spline structure of an eighth embodiment of the present invention.
  • Figure 30 is a schematic view showing the state in which the external spline structure and the internal spline structure are connected in the eighth embodiment of the present invention.
  • outward refers to an extension line that extends in the radial direction starting from the axis of the left atrial appendage occluder, and includes both an extension line that is radially expanded perpendicular to the axis, and a non-right angle to the axis.
  • inward refers to an extension line that extends in the radial direction at the end of the axis of the left atrial appendage occluder, and includes an extension line that is radially expanded perpendicular to the axis, and includes An axis extending radially beyond the right angle.
  • Proximal and distal are relative orientations, relative positions, directions of elements or actions relative to each other from the perspective of the physician using the medical device, although “proximal” and “distal” are not limiting "Proximal” generally refers to the end of the medical device that is near the doctor during normal operation, while “distal” generally refers to the end that first enters the patient.
  • FIG. 1 is a schematic perspective view of a left atrial appendage occluder according to a first embodiment of the present invention
  • FIG. 2 is a schematic top view of a left atrial appendage occluder according to a first embodiment of the present invention
  • the left atrial appendage occluder 1 includes a plurality of support beams 11 distributed on the outer side of a first hub 10 and extending outward, the support beam 11 being A position 110 is divided into a left support beam 111 and a right support beam 112, and the left support beam 111 and the right support beam 112 adjacent to the support beam 11 are connected at a second position 113 and extend distally to form a far distance.
  • the end of the adjacent support beam 11 of the left atrial appendage occluder 1 includes a support rod 12.
  • the stability of the left atrial appendage occluder 1 is ensured by the above design, and irregular deformation and lateral slippage do not occur.
  • the support rod 12 in the middle of the adjacent support beam 11 causes the left atrial appendage occluder 1 A dense mesh is formed which can further increase the overall strength of the left atrial appendage occluder 1.
  • the angle between adjacent support beams 11 is 45°. That is, preferably, eight support beams 11 are distributed outside the first hub 10. The distribution of the support beam 11 and the support beam 11 at a specific angle can ensure that the left atrial appendage occluder 1 has better stability and is less prone to deformation, and at the same time enables the left atrial appendage occluder 1 to be easily Release and recycling.
  • the first end 120 of the support rod 12 is connected to the outer side of the first hub 10 , and the first end 120 of the support rod 12 extends outward and is in the third
  • the position 121 is divided into a second end 122 and a third end 123.
  • the second end 122 is fixed between the first position 110 and the second position 113 of the left support beam 111
  • the third end 123 is fixed to the first position 110 of the right support beam 112 and Between the second positions 113.
  • the second end 122 and the third end 123 are respectively fixed on the adjacent two support beams 11.
  • a certain supporting force of the adjacent two supporting beams 11 is given by the one supporting rod 12, whereby the stability of the left atrial appendage occluder 1 can be further ensured. In particular, avoid irregular deformation and lateral slippage.
  • the length of the support rod 12 from the first hub 10 to the third position 121 is smaller than the length of the support beam 11 from the first hub 10 to the first position 110. Thereby, the structure of the support rod 12 can be made more stable, thereby giving the support beam 11 a better supporting force.
  • the first end 120, the second end 122 and the third end 123 of the support rod 12 have a "Y" shape, that is, the first end 120, the second end 122 and the third end of the support rod 12.
  • 123 is a symmetrical structure.
  • the "Y" shaped structure has excellent stability and reliability, which also makes the support rod 12 have excellent stability and reliability.
  • the third position 121 is located at a position between the support rod 12 at a distance of 1/5 to 4/5 in the radial direction, thereby facilitating tube cutting to form the support rod 12 and subsequent expansion and shaping .
  • all or part of the support beam 11 includes a barb 13 , and/or all or part of the left support beam 111 and the right support beam 112 .
  • a barb 13 is included on the top.
  • the fixing of the left atrial appendage occluder 1 on the left atrial appendage can be improved by the barbs 13.
  • the barbs 13 are integrally formed with the support beam 11, the left support beam 111 and/or the right support beam 112 by a cutting process, thereby simplifying the process and ensuring the reliability of the structure.
  • the distal ends of the left support beam 111 and the right support beam 112 formed by the same support beam 11 are connected.
  • the stability of the support beam 11 in the circumferential direction can be improved, and further The stability and reliability of the left atrial appendage occluder 1 are improved.
  • FIG. 4 is a partially enlarged schematic view of a left atrial appendage occluder according to a first embodiment of the present invention.
  • the extension continues to reach the ends of the left support beam 111 and the right support beam 112.
  • the distal ends of the left and right support beams 111 and 112 are connected to the end, and the distal ends of the left and right support beams 111 and 112 are bent proximally to form an anchor 14.
  • the left atrial appendage occluder 1 can be firmly fixed to the left atrial appendage by the anchor 14.
  • the length of the distal bend point 115 to the end 116 is greater than the length 116 of the distal attachment point 114 to the end. It can be seen that the degree of bending of the anchor 14 is relatively large, and the structure of the anchor 14 is more stable through the arrangement of the distal connection point 114, so that the ability to grasp the hook of the left atrial appendage can be improved, that is, The fixation of the left atrial appendage occluder 1 on the left atrial appendage can be improved.
  • the distal end of the connecting point 114 to the end 116 has a length of 1 mm to 3 mm, and the distal end of the bending point 115 to the distal connecting point 114 has a length of less than 3 mm.
  • the anchor is formed after the distal ends of the left support beam 111 and the right support beam 112 are connected, whereby the distal connection point 114 can become the anchor grapple.
  • the termination point so the grapple will not pierce the heart tissue because it is too long, thereby protecting the anchor from damage to the left atrial appendage.
  • the left atrial appendage occluder 1 can be integrally formed. Specifically, it can be realized by cutting a tube to form a first hub 10, a support beam 11, a support rod 12, and an anchor 14. Integrated molding simplifies the production process and saves economic costs such as manpower and materials.
  • left atrial appendage occluder 1 at least partially covers a biocompatible membrane.
  • the above left atrial appendage occluder 1 can be used in the following manner:
  • the left atrial appendage occluder is guided to the end of the catheter by a channel established by the catheter through the catheter and released at the end.
  • the left atrial appendage occluder 1 comes out of the sheath tube, and after the anchor is fixed and positioned on the left atrial appendage wall, the support beam 11 and the support rod 12 are expanded and buckled on the left atrial appendage wall wall to fully fit to achieve the best.
  • the blocking effect In the case of recycling, the direction is reversed, and the anchor is naturally recovered from the wall of the left atrial appendage.
  • FIG. 5 is a schematic diagram of a state of a left atrial appendage occluder on a left atrial appendage according to a first embodiment of the present invention.
  • the left atrial appendage occluder 1 is released into the left atrial appendage 7, the left atrial appendage occluder 1 is expanded, at which time the barbs 13 and the anchor 14 are fixed to the left atrial appendage 7.
  • FIG. 6 is a schematic perspective view of a left atrial appendage occluder according to a second embodiment of the present invention
  • FIG. 7 is a cross-sectional view of the left atrial appendage occluder according to the second embodiment of the present invention.
  • the left atrial appendage occluder 3 includes a plurality of support beams 31 distributed on the outer side of a first hub 30 and extending outward, the support beam 31 being A position 310 is divided into a left support beam 311 and a right support beam 312.
  • the left support beam 311 and the right support beam 312 adjacent to the support beam 31 are connected at a second position 313 and extend distally to form a far distance.
  • the end of the adjacent support beam 31 of the left atrial appendage occluder 3 includes a support rod 32.
  • first end 320 of the support rod 32 is connected to the outer side of the first hub 30, the first end 320 of the support rod 32 extends outward, and is separated into a second end at the third position 321 322 and a third end 323.
  • the second end 322 is fixed between the first position 310 and the second position 313 of the left support beam 311, and the third end 323 is fixed to the first position 310 of the right support beam 312 and Between the second positions 313.
  • the second end 322 and the third end 323 are respectively fixed on the adjacent two support beams 31.
  • All or part of the support beam 31 includes a barb 33, and/or all or part of the left support beam 311 and the right support beam 312 include a barb 33.
  • the distal ends of the left support beam 311 and the right support beam 312 formed by the same support beam 31 are connected.
  • the distal ends of the left and right support beams 311, 312 are bent proximally to form an anchor 34.
  • the left atrial appendage occluder 3 further includes a second hub 35. Specifically, the distal end extends inwardly and forms a second hub 35. With continued reference to FIG. 6, in particular, the distal ends of the left and right support beams 311, 312 extend inwardly to form a second hub 35. Further, the first hub 30 is coaxial with the second hub 35. Thereby, the left atrial appendage occluder 3 can be made to have excellent symmetry, thereby facilitating the release and recovery of the left atrial appendage occluder 3.
  • the above left atrial appendage occluder 3 can be used in the following manner:
  • the left atrial appendage occluder is guided to the end of the catheter by a channel established by the catheter through the catheter and released at the end.
  • the left atrial appendage occluder 3 emerges from the sheath tube, and after the anchor is fixed and positioned on the left atrial appendage wall, the support beam 31 and the support rod 32 are expanded and buckled on the left atrial appendage wall wall to fully fit to achieve the best.
  • the blocking effect In the case of recycling, the direction is reversed, and the anchor is naturally recovered from the wall of the left atrial appendage. Since the distal end of the left atrial appendage occluder 3 in the second embodiment extends inwardly and forms a second hub 35, it has better recovery and release capabilities.
  • the distal end may extend along a direction toward the proximal end and form a second hub 35; in other embodiments of the present application, the distal end may also face the The distal end extends and forms a second hub 35, as shown in Figure 8.
  • the projection of the first hub 30 is the same as the projection of the second hub 35. In other embodiments of the present application, the projection of the first hub 30 is opposite the projection of the second hub 35, as shown in FIG.
  • FIG. 10 is a perspective structural diagram of a left atrial appendage occluder according to a third embodiment of the present invention.
  • the left atrial appendage occluder 4 includes a plurality of support beams 41 distributed on an outer side of a first hub 40 and extending outwardly.
  • the support beam 41 is at a first position 410.
  • Divided into a left support beam 411 and a right support beam 412, the left support beam 411 and the right support beam 412 adjacent to the support beam 41 are connected at a second position 413 and extend distally to form a distal end;
  • the support beam 42 is included in the middle of the adjacent support beam 41 of the left atrial appendage occluder 4.
  • the distal end extends inwardly and forms a second hub 45.
  • first end 420 of the support rod 42 is connected to the outer side of the first hub 40.
  • the first end 420 of the support rod 42 extends outwardly and is separated into a second end at the third position 421. 422 and a third end 423.
  • the second end 422 is fixed between the first position 410 and the second position 413 of the left support beam 411
  • the third end 423 is fixed to the first position 410 of the right support beam 412 and Between the second positions 413.
  • the second end 422 and the third end 423 are respectively fixed to the adjacent two support beams 41.
  • All or part of the support beam 41 includes a barb 43 and/or all or part of the left support beam 411 and the right support beam 412 include a barb 43.
  • the difference between the third embodiment and the second embodiment is that in the third embodiment, the distal ends of the left support beam 411 and the right support beam 412 formed by the same support beam 41 are no longer connected and protrude directly outward in the radial direction.
  • An anchor 44 is formed.
  • a distal end of the distal abutment is formed by the distal end to form an anchor 44 so that the left atrial appendage occluder 4 can be firmly fixed to the left atrial appendage.
  • FIG. 11 is a cross-sectional view of a left atrial appendage occluder according to a fourth embodiment of the present invention.
  • the structure of the fourth embodiment is the same as that of the first embodiment. The only difference is that the support beam and the support rod in the fourth embodiment are double-layered nickel-titanium alloy structures. Thereby the left atrial appendage occluder 5 has better quality and stability.
  • the left atrial appendage occlusion device in the second embodiment and the third embodiment has the first hub, the second hub and the connection a cage structure connecting the first hub and the second hub (the support beam and the support rod form a dense mesh, and the mesh connecting the first hub and the second hub forms a cage structure), belonging to the cage occlusion Left atrial appendage occluder.
  • the cage-type occlusion type left atrial appendage occluder shown in FIG. 12 is taken as an example to explain the structure and working principle of the delivery system of the left atrial appendage occluder.
  • Referring to the perspective view of the left atrial appendage occluder in FIG. Figure 12 may have the same or similar structure as the left atrial appendage occluder of the second embodiment shown in Figure 6, for simplicity, only the first hub 30, the anchor 34, the second hub 35 and the cage are labeled Structure 36.
  • the left atrial appendage occluder 3 includes a first hub 30, a second hub 35, and a cage structure 36 connecting the first hub 30 and the second hub 35, the cage structure 36 having Anchor 34.
  • the cage structure 36 has a plurality of rows of anchors 34, so that the left atrial appendage occluder 3 can be more easily fixed to the left atrial appendage, and can be more stably and reliably fixed to the left atrial appendage. .
  • the cage-occluded left atrial appendage occluder can also have other structural forms, and the delivery system of the left atrial appendage occluder of the present invention is applicable to this; in addition, the most typical cage occlusion in the left atrial appendage occluder In addition to the left atrial appendage occluder, there are other structural forms, and the present invention is equally applicable.
  • FIG. 13 is a structural schematic diagram of a delivery system of a left atrial appendage occluder according to a fifth embodiment of the present invention.
  • the transport system 6 includes a first transport unit 60 and a second transport unit 61 located inside the first transport unit 60.
  • the first conveying portion 60 may be separated or connected to the first hub 30 (of the left atrial appendage occlusion device 3), and the second conveying portion 61 may be associated with the (left atrial appendage occlusion device 3)
  • the second hub 35 is separated or connected.
  • the first conveying portion 60 is connected to the first hub 30 of the left atrial appendage occluder 3; the second conveying portion 61 and the second hub 35 of the left atrial appendage occluder 3
  • the connection can thereby cause the left atrial appendage occluder 3 to be gathered and then the left atrial appendage occluder 3 to be sheathed, so that the design of the left atrial appendage occluder 3 in the sheath can be prevented from being too long.
  • FIG. 14 is a schematic diagram of a state in which the delivery system of the left atrial appendage occluder is not released when the left atrial appendage occluder is released according to the fifth embodiment of the present invention.
  • the conveying system 6 further includes a sheath tube 62, and the first conveying portion 60 is located inside the sheath tube 62.
  • the delivery system 6 does not release the left atrial appendage occluder 3
  • the first delivery portion 60 is coupled to the first hub 30, and the second delivery portion 61 is coupled to the second hub 35.
  • first hub 30 is engaged with the second hub 35 such that the left atrial appendage occluder 3 is brought together, relative to the
  • the case where the first hub 30 and the second hub 35 are separated in the sheath tube 62 greatly reduces the length of the left atrial appendage occluder 3 in the sheath tube, thereby facilitating the left atrial appendage. Release of the occluder 3.
  • the cage structure 34 of the left atrial appendage occluder 3 is folded to form a first portion 360 and a second portion 361; one end of the first portion 360 is coupled to the first hub 30, The other end is connected to one end of the second portion 361, and the other end of the second portion 361 is connected to the second hub 35.
  • a plurality of anchors 34 may be disposed on the first portion 360 and the second portion 361 of the left atrial appendage occluder 3.
  • the second portion 361 is located inside the first portion 360.
  • the first portion 360 overlaps the second portion 361 in the vertical direction, thereby greatly reducing the length of the left atrial appendage occluder 3 in the sheath. Since the left atrial appendage occluder 3 is in a folded state when positioned inside the delivery system 6, the anchor 34 on the second portion 361 is located in the interior space and does not move into the sheath 62 and in the sheath 62. When the sheath tube 62 is contacted, there is no case where the sheath 62 is scratched.
  • the left atrial appendage occluder 3 (corresponding to FIG. 6 and FIG. 12 may be correspondingly)
  • the sheath 62 comes out.
  • the left atrial appendage occluder 3 first comes out of the sheath 62 as a first portion 360 and an anchor 34 thereon.
  • the delivery system 6 is still connected to the left atrial appendage occluder 3, ie the delivery system 6 is still capable of controlling the left atrial appendage occluder 3, and the physician can adjust the fixation of the anchor 34 to the left atrial appendage, thereby Implement repeated positioning.
  • the second conveying portion 61 continues to be pushed out of the sheath tube 62 (when the first conveying portion 60 can be stopped from being pushed out of the sheath tube 62 or relatively pushed out from the sheath tube 62). At this time, other portions of the left atrial appendage occluder 3 also come out of the sheath tube 62. Since the first hub 30 and the second hub 35 are still connected to the first conveying portion 360 and the second conveying portion 361 at this time, that is, the state of the left atrial appendage occluder 3 is still controllable (by the doctor), At this point, the doctor can still adjust the fixation of the anchor 34 to the left atrial appendage to achieve repeated positioning.
  • the doctor when the doctor has fixed the left atrial appendage occluder 3 in place on the left atrial appendage, it can release the left atrial appendage occluder 3. Specifically, the second conveying portion 61 is separated from the second hub 35, and the first conveying portion 60 is separated from the first hub 30. At this time, the left atrial appendage occluder 3 can no longer be repeatedly positioned.
  • the second conveying portion 61 and the second hub 35 is connected by a threaded nut structure, and the connection between the second conveying portion 61 and the second hub 35 can be realized by tightening and loosening the threaded nut structure of the second conveying portion 61 and the second hub 35.
  • the second conveying portion 61 and the second hub 35 may also be connected by other connecting means, for example, an external spline internal spline structure connection or a snap structure connection.
  • the first hub 30 and the second hub 35 are specifically engaged by: the distal end of the first hub 30 includes a step 300, when the first hub 30 and the When the second hub 35 is engaged, the proximal end of the second hub 35 is located on the step 300.
  • the first conveying portion 60 is connected to the first hub 30 by a proximal end of the first hub 30 including a groove 301, and a distal end of the first conveying portion 60 is located in the groove 301 Inside. Thereby, the first conveying portion 60 is connected to the first hub 30 in a simple manner; at the same time, the first conveying portion 60 and the first hub 30 can be easily separated when released.
  • the left atrial appendage occluder 3 can be fixed on the left atrial appendage 7 (refer to FIG. 18 and FIG. 6 respectively), thereby achieving the sealing of the left atrial appendage 7.
  • FIG. 19 is a schematic structural diagram of a limiting device according to Embodiment 5 of the present invention
  • FIG. 20 is a fixing device for fixing a first conveying portion and a second conveying portion according to Embodiment 5 of the present invention
  • the conveying system 6 further includes a limiting device 63 for fixing the first conveying portion 60 and the second conveying portion 61.
  • the limiting device 63 includes a clamping portion 630 and a biasing portion 631.
  • the clamping portion 630 includes a protruding block, and the protruding block passes through the first conveying portion 60.
  • the card slot 64 holds the second conveying portion 61.
  • the first transport unit 60 and the second transport unit 61 can be conveniently controlled by the position limiting device 63 to perform an overall pushing operation of the first transport unit 60 and the second transport unit 61.
  • a spring 632 is further connected to the urging portion 631 for fixing the clamping portion 630.
  • the delivery system 6 further includes a handle 65.
  • the handle 65 is located at the proximal end of the first conveying portion 60.
  • the advancement of the first delivery portion 60 and the second delivery portion 61 within the sheath 62 can also be facilitated by clamping the handle 65 and pushing, and ultimately effecting the left atrial appendage occluder The release of 3.
  • the handle 65 has a visual indication mark, and the visual indication mark may be a rotary identification mark of the threaded nut structure, which is a threaded nut structure of the second conveying portion 61 and the second hub 35. The identification mark is rotated, so that the left and right directions of the threads can be easily recognized, and the connection and separation between the second conveying portion 61 and the second hub 35 can be facilitated.
  • the release of the left atrial appendage occluder 3 can be achieved by the following process:
  • the first delivery portion 60 and the second delivery portion 61 are advanced within the sheath 62 by a handle 65 or a limiting device 63; then, the first portion of the left atrial appendage occluder 3 is released (through The first conveying portion 60 and the second conveying portion 61 are pushed out from the sheath tube 62 at a distal end, and the positioning and adjustment can be repeated a plurality of times; after the positioning of the first portion is completed, the second portion is released.
  • the limiting device 63 unscrews the threaded nut structure of the second conveying portion 61 and the second hub 35, so that the second conveying portion 61 is separated from the second hub 35.
  • the left atrial appendage occluder 3 can be The button is buckled on the left atrial appendage 7; then the first delivery portion 60 is pulled back to release the left atrial appendage occluder 3.
  • the problem that the left atrial appendage occluder is too long in the sheath can be avoided; at the same time, repeated positioning can be realized when releasing, which is better.
  • the sheathing or release of the left atrial appendage occluder is achieved.
  • FIG. 21 to FIG. 23 are diagrams showing the state of the delivery system of the left atrial appendage occluder according to Embodiment 6 of the present invention when the left atrial appendage occluder portion is released.
  • the delivery system 8 includes a first delivery portion 80 and a second delivery portion 81 located within the first delivery portion 80.
  • the first conveying portion 80 is separated or connected to the first hub 30 (of the left atrial appendage occluder 3), and the second conveying portion 81 and the second (of the left atrial appendage occluder 3)
  • the hubs 35 are separated or connected.
  • the first delivery portion 80 is coupled to the first hub 80 of the left atrial appendage occluder 3; the second delivery portion 81 is blocked from the left atrial appendage
  • the second hub 35 of the device 3 is connected, whereby the left atrial appendage occluder 3 can be gathered, and then the left atrial appendage occluder 3 can be sheathed to avoid the length of the left atrial appendage occluder 3 in the sheath. Too long a problem.
  • the second conveying portion 81 and the second hub 35 are connected in the same manner as in the first embodiment, and are also connected by a threaded nut structure.
  • the first conveying portion 80 is connected to the first hub 31 differently from the first embodiment.
  • the first conveying portion 80 and the first hub 31 are also threaded.
  • the nut structure is connected.
  • the proximal ends of the first conveying portion 80 and the second conveying portion 81 are respectively provided with a handle 83, wherein the handle 83 of the proximal end of the second conveying portion 81 can be separately implemented for Pushing of the second conveying unit 81.
  • a visual indicator is disposed on the handles 83 of the first conveying unit 80 and the second conveying unit 81.
  • the first conveying portion 80 is proximal end
  • a rotation identification mark of the threaded nut structure of the first conveying portion 80 and the first hub 31 is shown on the handle 83; the second conveying portion 81 and the second hub are shown on the handle 83 of the proximal end of the second conveying portion 81.
  • a rotation identification mark of the threaded nut structure of 35 whereby the connection and separation of the first conveying portion 80 and the first hub 31 can be conveniently realized, the second conveying portion 81 and the second hub 35 The connection is separated.
  • the delivery system 8 may also include a sheath tube, a limiting device, and the like. This part of the structure (including other structures not described in the second embodiment) may refer to the first embodiment, and the second embodiment will not be described again. .
  • the release of the left atrial appendage occluder 3 can be achieved by the following process:
  • the first delivery portion 80 and the second delivery portion 81 are advanced within the sheath 82 by a handle 83 or a limiting device (not shown); then, the left atrial appendage occluder is released.
  • the first portion of the third portion (which can be realized by pushing the sheath tube 82 distally by the first conveying portion 80 and the second conveying portion 81) can be repeatedly positioned and adjusted a plurality of times; positioning in the first portion After completion, the retaining device is then released, and the threaded nut structure of the second conveying portion 81 and the second hub 35 is loosened, so that the second conveying portion 81 is separated from the second hub 35.
  • the occluder 3 can be fastened to the left atrial appendage; then the left atrial occluder 3 can be released by loosening the threaded nut structure of the first delivery portion 80 and the first hub 35.
  • the problem that the left atrial appendage occluder is too long in the sheath can be avoided; at the same time, repeated positioning can be realized when releasing, which is better.
  • the sheathing or release of the left atrial appendage occluder is achieved.
  • FIG. 24 is a schematic diagram of a state in which the delivery system of the left atrial appendage occluder is released in the left atrial appendage occluder portion according to Embodiment 7 of the present invention.
  • the transport system 9 includes a first transport unit 90 and a second transport unit 91 located in the first transport unit 90.
  • the first conveying portion 90 is separated or connected to the first hub 30 (of the left atrial appendage occluder 3), and the second conveying portion 91 and the second (of the left atrial appendage occluder 3)
  • the hubs 35 are separated or connected.
  • the first delivery portion 90 is coupled to the first hub 30 of the left atrial appendage occluder 3; the second delivery portion 91 is blocked from the left atrial appendage
  • the second hub 35 of the device 3 is connected, whereby the left atrial appendage occluder 3 can be gathered, and then the left atrial appendage occluder 3 can be sheathed to avoid the length of the left atrial appendage occluder 3 in the sheath. Too long a problem.
  • the distal end of the first conveying portion 90 has a trumpet shape.
  • the second conveying portion 91 and the second hub 35 are connected by a threaded nut structure; the connection between the first conveying portion 90 and the first hub 30 passes through the top of the first conveying portion 90 Living in the first hub 30 is achieved. Since the distal end of the first conveying portion 90 has a flare shape, after the second conveying portion 91 and the second hub 35 are connected by a threaded nut structure, the first conveying portion 90 can withstand the The first hub 30 is such that the left atrial appendage occluder 3 can be gathered.
  • the delivery system 9 may also include a sheath tube, a limiting device, a handle, and the like.
  • This part of the structure (including other structures not described in the third embodiment) may refer to the first embodiment, and the third embodiment does not Let me repeat.
  • the left atrial appendage occluder 3 can be released by the following process:
  • the left atrial appendage occluder 3 can be buckled on the left atrial appendage; then the first conveying portion 90 is pulled back, that is, The left atrial appendage occluder 3 can be released.
  • the problem that the left atrial appendage occluder is too long in the sheath can be avoided; at the same time, repeated positioning can be realized when releasing, which is better.
  • the sheathing or release of the left atrial appendage occluder is achieved.
  • the conveying system includes: a first conveying portion and a second conveying portion located in the first conveying portion. Wherein the first conveying portion is separated or connected to the first hub 30 (of the left atrial appendage occluder 3), and the second conveying portion and the second hub 35 (of the left atrial appendage occluder 3) Separate or connected.
  • the first delivery portion is connected to the first hub 30 of the left atrial appendage occluder 3; the second delivery portion is opposite to the left atrial appendage occluder 3
  • the second hub 35 is connected, whereby the left atrial appendage occluder 3 can be gathered, and then the left atrial appendage occluder 3 can be sheathed to avoid the length of the left atrial appendage occluder 3 in the sheath. problem.
  • the main difference between the eighth embodiment and the fifth embodiment, the sixth embodiment or the seventh embodiment is that the first hub can be connected to the second hub.
  • FIG. 25 is a left atrial appendage occluder according to Embodiment 8 of the present invention.
  • FIG. 26 is a schematic view showing another state of the delivery system of the left atrial appendage occluder according to the eighth embodiment of the present invention when the left atrial appendage occluder is fully released.
  • the first hub 30 and the second hub 35 may be partially or fully connected.
  • the left atrial appendage occluder can be better adapted to different left atrial appendages by the position at which the first hub 30 is partially or fully connected and connected to the second hub 35.
  • the left atrial appendage occluder can better adapt to the smaller left atrial appendage;
  • the left atrial appendage occluder can better accommodate the larger left atrial appendage;
  • the second When the hub 35 is separated from the first hub 30 (as shown in Figure 27), the left atrial appendage occluder is better able to accommodate a larger left atrial appendage.
  • first hub 30 and the second hub 35 may be connected by a snap structure or an external spline internal spline structure or the like.
  • first hub 30 and the second hub 35 are connected by a snap structure (refer to FIG. 25 to FIG. 27 respectively), wherein the first hub 30 is provided with an inner snap structure, the second hub 35 is provided with an outer snap structure; for example, the first hub 30 and the second hub 35 are connected by an external spline internal spline structure (wherein the external spline internal spline structure and the state of the two are connected) Reference is made to FIGS. 28 to 30), wherein the first hub 30 is provided with an internal spline structure and the second hub 35 is provided with an external spline structure.
  • first hub 30 may be connected to the first conveying portion by an externally threaded nut structure
  • second hub 35 may be connected to the second conveying portion by a female nut.
  • the delivery system includes a first conveying portion and a second conveying portion located in the first conveying portion, before the sheathing, a delivery portion is coupled to the first hub of the left atrial appendage occluder; the second delivery portion is coupled to the second hub of the left atrial appendage occluder, whereby the left atrial appendage occluder can be collapsed, and then the The left atrial appendage occluder is sheathed to avoid the problem that the left atrial appendage occluder is too long in the sheath.
  • the second portion of the left atrial appendage occluder provided with the anchor is first released, at which point the positioning can be repeated until a suitable fixed position is reached, and then the second hub of the left atrial appendage occluder and the first hub are released.
  • the delivery system of the left atrial appendage occluder provided by the present invention can better achieve the sheathing or release of the left atrial appendage occluder.

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Abstract

一种左心耳封堵器(1)及其输送装置(6)，左心耳封堵器(1)包括多个支撑梁(11)，支撑梁(11)分布于一第一毂(10)的外侧并向外延伸，支撑梁(11)于第一位置(110)处分开为一左支撑梁(111)及一右支撑梁(112)，相邻支撑梁(11)的左支撑梁(111)及右支撑梁(112)于第二位置(113)处连接并向远侧延伸形成一远端，相邻支撑梁(11)中间包括一支撑杆(12)，保证了左心耳封堵器(1)的稳固性，不会发生不规则变形和侧向滑移。相邻支撑梁(11)中间的支撑杆(12)使得左心耳封堵器(1)形成了密集的网格，可以进一步提高左心耳封堵器(1)的整体强度。

Description

左心耳封堵器及其输送系统 技术领域
本发明涉及医疗器械技术领域，特别涉及一种左心耳封堵器及其输送系统。
背景技术
心房颤动(房颤)是临床上最常见的持续性心律失常，普通人群中房颤发病率为0.5％～1.3％。房颤最主要的危害是促进血栓形成，血栓脱落后容易导致脑卒中、外周血管栓塞等并发症，显著增加致残率和致死率。脑卒中为房颤最常见、危害最大的并发症，世界范围内每年约有1500万人罹患脑卒中，其中20％～25％归因于房颤。研究显示，60％的风湿性心脏病房颤患者心源性血栓来自左心耳，非瓣膜病房颤患者中90％以上血栓形成于左心耳。因此，干预左心耳预防房颤患者血栓栓塞，尤其是卒中，具有重要的理论依据和临床意义。
抗凝治疗目前是预防房颤卒中并发症的标准方法，但是抗凝治疗存在一定局限。因此采用更加有效安全的措施预防房颤卒中具有重要意义。目前多采用利用内科介入治疗闭塞左心耳的方法。常用的左心耳封堵器有以WATCHMAN为代表的单体内塞型封堵器和以AMPLATZER Cardiac Plug(ACP)为代表的塞盘式左心耳封堵器。
1、内塞型左心耳封堵器的缺陷和不足
内塞型左心耳封堵器是以镍钛合金作为自膨胀结构的框架，周围有固定倒钩，心房面由聚四氟乙烯多孔渗透膜覆盖，血流可进出左心耳。
当该器械塞入左心耳时，由于左心耳口部形状很不规则，而该器械的变形能力有限，不能完全封堵左心耳口部，难以消除由于房颤而造成左心耳部形成血栓。左心耳的结构形状各异、深度各异，还有多腔结构，内塞型左心耳封堵器不能完全适应所有的左心耳的解剖结构，同时无法实现稳定固定。
2、塞盘型左心耳封堵器的缺陷和不足
塞盘型左心耳封堵器是一种双碟样左心耳封堵装置，由置于左心耳的蝶形叶片和蝶形帽组成，二者中间由凹陷的腰部连接，蝶形叶片置于左心耳防止封堵器移位，蝶形帽封住左心耳口部。
塞盘式左心耳封堵器为封堵盘和固定盘一体，不能完全独立地变形，当塞 子塞入左心耳后，碟盘部分扣在左心耳的口部时，会受到塞子部分的牵拉，使得碟盘部分不能充分贴合在左心耳的口部，很难达到最佳的封堵效果。由于塞子部分和碟盘部分的长度调节有限难以实现最佳固定和血流阻断，同时碟盘结构并不适应不同的左心耳内腔形状。
总之，不管是内塞型或者塞盘型左心耳封堵器，都存在强度不够的问题。
此外，如何更好的实现左心耳封堵器的入鞘或者释放，成了本领域技术人员亟待解决的技术难题。
发明内容
本发明的一个目的在于提供一种左心耳封堵器，以解决现有的左心耳封堵器强度不够的问题。
为解决上述技术问题，本发明提供一种左心耳封堵器，所述左心耳封堵器包括多个支撑梁，所述支撑梁分布于一第一毂的外侧并向外延伸，所述支撑梁于第一位置处分开为一左支撑梁及一右支撑梁，相邻所述支撑梁的左支撑梁及右支撑梁于第二位置处连接并向远侧延伸形成一远端；所述左心耳封堵器的相邻支撑梁中间包括一支撑杆。
可选的，在所述的左心耳封堵器中，所述支撑杆的第一端连接所述第一毂的外侧，所述支撑杆的第一端向外延伸，并于第三位置处分开为一第二端及一第三端。
可选的，在所述的左心耳封堵器中，所述第二端固定于所述左支撑梁的第一及第二位置之间，所述第三端固定于所述右支撑梁的第一及第二位置之间。
可选的，在所述的左心耳封堵器中，所述第二端和第三端分别固定于相邻的两个支撑梁上。
可选的，在所述的左心耳封堵器中，所述支撑杆从所述第一毂至所述第三位置的长度小于所述支撑梁从所述第一毂到所述第一位置的长度。
可选的，在所述的左心耳封堵器中，所述支撑杆的第一端、第二端及第三端呈一“Y”字形。
可选的，在所述的左心耳封堵器中，所述全部或部分的支撑梁上包括一倒钩，和/或所述全部或部分的左支撑梁及右支撑梁上包括一倒钩。
可选的，在所述的左心耳封堵器中，同一支撑梁所形成的左支撑梁及右支 撑梁的远端连接。
可选的，在所述的左心耳封堵器中，所述远端向近端弯折以形成一锚状物。
可选的，在所述的左心耳封堵器中，所述远端的弯折点至末端的长度大于所述远端连接点至末端的长度。
可选的，在所述的左心耳封堵器中，所述远端向内延伸并形成一第二毂。
可选的，在所述的左心耳封堵器中，所述远端沿径向突起以形成一锚状物。
可选的，在所述的左心耳封堵器中，所述第一毂与所述第二毂共轴。
可选的，在所述的左心耳封堵器中，所述第一毂沿轴向凸起的方向与第二毂沿轴向凸起的方向相同或相反。
可选的，在所述的左心耳封堵器中，所述左心耳封堵器至少部分覆盖一生物相容膜。
可选的，在所述的左心耳封堵器中，相邻所述支撑梁之间的角度为45°。
在本发明提供的左心耳封堵器中，包括多个支撑梁，所述支撑梁分布于一第一毂的外侧并向外延伸，所述支撑梁于第一位置处分开为一左支撑梁及一右支撑梁，相邻所述支撑梁的左支撑梁及右支撑梁于第二位置处连接并向远侧延伸形成一远端，相邻支撑梁中间包括一支撑杆，保证了左心耳封堵器的稳固性，不会发生不规则变形和侧向滑移，特别的，相邻支撑梁中间的支撑杆使得所述左心耳封堵器形成了密集的网格，可以进一步提高左心耳封堵器的整体强度。本发明所提供的左心耳封堵器的自膨胀框架和锚状物一体成型，不需要增加额外的工艺步骤制作锚状物。本发明所提供的左心耳封堵器的锚定部件既能提供强而有效的锚定效果,有效防止心房纤维颤动产生的力导致封堵器的移位,还能避免因锚钩过大导致的刺穿组织。
本发明的另一个目的在于提供一种左心耳封堵器的输送系统，以更好的实现左心耳封堵器的入鞘或者释放。
为解决上述技术问题，本发明提供一种左心耳封堵器的输送系统，用于释放一左心耳封堵器，所述输送系统包括第一输送部以及位于所述第一输送部内的第二输送部；
所述第一输送部用于与所述左心耳封堵器的第一毂分开或连接；
所述第二输送部用于与所述左心耳封堵器的第二毂分开或连接。
可选的，在所述的左心耳封堵器的输送系统中，所述输送系统未释放所述左 心耳封堵器时，所述第一毂与所述第二毂相接合。
可选的，在所述的左心耳封堵器的输送系统中，所述输送系统还包括一鞘管，所述第一输送部位于所述鞘管内部。
可选的，在所述的左心耳封堵器的输送系统中，所述输送系统还包括一限位装置，用于固定所述第一输送部及第二输送部。
可选的，在所述的左心耳封堵器的输送系统中，所述限位装置包括一夹持部以及一施力部，所述夹持部部分或全部通过位于所述第一输送部上的卡槽，夹持所述第二输送部。
可选的，在所述的左心耳封堵器的输送系统中，所述输送系统还包括一手柄，所述手柄位于所述第一输送部和/或所述第二输送部的近端，所述手柄上具有一可视化标志。
可选的，在所述的左心耳封堵器的输送系统中，所述左心耳封堵器包括一第一部分和一第二部分；所述第一部分的一端连接所述第一毂，另一端连接所述第二部分的一端，所述第二部分的另一端连接所述第二毂。
可选的，在所述的左心耳封堵器的输送系统中，所述输送系统未释放所述左心耳封堵器时，所述第二部分位于所述第一部分内。
可选的，在所述的左心耳封堵器的输送系统中，所述第一部分和/或所述第二部分设置若干锚状物。
可选的，在所述的左心耳封堵器的输送系统中，所述第一毂的远端包括一台阶，当所述第一毂与所述第二毂相接合时，所述第二毂的近端位于所述台阶上。
可选的，在所述的左心耳封堵器的输送系统中，所述第一毂的近端包括一凹槽，所述第一输送部的远端位于所述凹槽内。
可选的，在所述的左心耳封堵器的输送系统中，所述第一输送部的远端呈喇叭状。
可选的，在所述的左心耳封堵器的输送系统中，当所述第一毂与所述第二毂相接合时，所述第一毂与第二毂通过外花键内花键结构连接或者卡扣结构连接。
可选的，在所述的左心耳封堵器的输送系统中，所述第一输送部与所述第一毂通过螺纹螺母结构连接、外花键内花键结构连接或者卡扣结构连接和/或所述第二输送部与所述第二毂通过螺纹螺母结构连接、外花键内花键结构连接或者卡扣结构连接。
在本发明提供的左心耳封堵器的输送系统中，所述输送系统包括第一输送部以及位于所述第一输送部内的第二输送部，在入鞘前，第一输送部与左心耳封堵器的第一毂连接；第二输送部与所述左心耳封堵器的第二毂连接，由此可以使得所述左心耳封堵器收拢，然后再将所述左心耳封堵器入鞘，便可以避免左心耳封堵器在鞘管内长度过长的问题。在释放时，左心耳封堵器中设置有锚状物的第二部分先释放，此时可以重复定位直至达到合适的固定位置，然后再释放左心耳封堵器的第二毂及第一毂。可见，本发明提供的左心耳封堵器的输送系统能够更好的实现左心耳封堵器的入鞘或者释放。
附图说明
图1是本发明实施例一的左心耳封堵器的立体结构示意图；
图2是本发明实施例一的左心耳封堵器的俯视示意图；
图3是本发明实施例一的左心耳封堵器的局部放大示意图；
图4是本发明实施例一的左心耳封堵器的局部放大示意图；
图5是本发明实施例一的左心耳封堵器在左心耳上的状态示意图；
图6是本发明实施例二的左心耳封堵器的立体结构示意图；
图7是本发明实施例二的左心耳封堵器的剖视示意图；
图8是本发明实施例二的另一左心耳封堵器的剖视示意图；
图9是本发明实施例二的另一左心耳封堵器的剖视示意图；
图10是本发明实施例三的左心耳封堵器的立体结构示意图；
图11是本发明实施例四的左心耳封堵器的剖视示意图；
图12是本发明实施例五的左心耳封堵器的输送系统所输送的左心耳封堵器的结构示意图；
图13是本发明实施例五的左心耳封堵器的输送系统的结构示意图；
图14是本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器未释放时的状态示意图；
图15是本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图；
图16是本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器部分释放时的又一状态示意图；
图17是本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器全部释放时的状态示意图；
图18是本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器锚定在左心耳上的状态示意图；
图19是本发明实施例五的限位装置的结构示意图；
图20是本发明实施例五的限位装置固定第一输送部和第二输送部的结构示意图；
图21是本发明实施例六的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图；
图22是本发明实施例六的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图；
图23是本发明实施例六的左心耳封堵器的输送系统在左心耳封堵器全部释放时的状态示意图；
图24是本发明实施例七的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图；
图25是本发明实施例八的左心耳封堵器的输送系统在左心耳封堵器全部释放时的状态示意图；
图26是本发明实施例八的左心耳封堵器的输送系统在左心耳封堵器全部释放时的另一状态示意图；
图27是本发明实施例八的左心耳封堵器的输送系统在左心耳封堵器全部释放时的另一状态示意图；
图28是本发明实施例八的外花键结构；
图29是本发明实施例八的内花键结构；
图30是本发明实施例八的外花键结构与内花键结构连接下的状态示意图。
具体实施方式
以下结合附图和具体实施例对本发明提出的左心耳封堵器及其输送系统作进一步详细说明。根据下面说明和权利要求书，本发明的优点和特征将更清楚。需说明的是，附图均采用非常简化的形式且均使用非精准的比例，仅用以方便、明晰地辅助说明本发明实施例的目的。特别的，由于各附图所要突出的内容不 同，往往采用了不同的比例。
在本文中，不论是否明确指出，所有数值都被假定为可用术语“大约”进行修饰。在使用数值的上下文中，术语“大约”通常是指本领域的技术人员将认为等同于所引用的值(即，具有相同功能或结果)及其邻近的一个范围。在许多情况下，术语“大约”可包括被四舍五入至最近的有效数字的数值。除非另有规定外，其他对术语“大约”的使用(即在除了使用数值以外的上下文中)可被假定为具有其普通和习惯定义，如可根据本说明书的上下文所理解的且与其保持一致。
在本文中，“向外”是指以该左心耳封堵器的轴线为起点，以辐射状方向展开的延伸线，既包括垂直于轴线辐射状展开的延伸线，也包括与轴线以非直角方式辐射状展开的延伸线；“向内”是指以该左心耳封堵器的轴线为终点，以辐射状方向展开的延伸线，既包括垂直于轴线辐射状展开的延伸线，也包括与轴线以非直角方式辐射状展开的延伸线。“近端”和“远端”是从使用该医疗器械的医生角度来看相对于彼此的元件或动作的相对方位、相对位置、方向，尽管“近端”和“远端”并非是限制性的，但是“近端”通常指该医疗设备在正常操作过程中靠近医生的一端，而“远端”通常是指首先进入患者体内的一端。
如在本说明书和所附权利要求中所使用的，单数形式“一”、“一个”以及“该”包括复数对象，除非内容另外明确指出外。如在本说明书和所附权利要求中所使用的，术语“或”通常是以包括“和/或”的含义而进行使用的，除非内容另外明确指出外。
【实施例一】
请参考图1至图3，其中，图1为本发明实施例一的左心耳封堵器的立体结构示意图，图2为本发明实施例一的左心耳封堵器的俯视示意图，图3为本发明实施例一的左心耳封堵器的局部放大示意图。如图1至图3所示，所述左心耳封堵器1包括多个支撑梁11，所述支撑梁11分布于一第一毂10的外侧并向外延伸，所述支撑梁11于第一位置110处分开为一左支撑梁111及一右支撑梁112，相邻所述支撑梁11的左支撑梁111及右支撑梁112于第二位置113处连接并向远侧延伸形成一远端；所述左心耳封堵器1的相邻支撑梁11中间包括一支撑杆12。通过上述设计保证了左心耳封堵器1的稳固性，不会发生不规则变形和侧向滑移，特别的，相邻支撑梁11中间的支撑杆12使得所述左心耳封堵器1 形成了密集的网格，可以进一步提高左心耳封堵器1的整体强度。
优选的，相邻所述支撑梁11之间的夹角为45°。即，较佳的，所述第一毂10的外侧分布有8根支撑梁11。支撑梁11与支撑梁11之间按照特定的角度分布，既能够保证所述左心耳封堵器1具有较佳的稳定性、不易于变形，同时又能够使得所述左心耳封堵器1易于释放与回收。
请继续参考图1至图3，具体的，所述支撑杆12的第一端120连接所述第一毂10的外侧，所述支撑杆12的第一端120向外延伸，并于第三位置121处分开为一第二端122及一第三端123。进一步的，所述第二端122固定于所述左支撑梁111的第一位置110及第二位置113之间，所述第三端123固定于所述右支撑梁112的第一位置110及第二位置113之间。所述第二端122和第三端123分别固定于相邻的两个支撑梁11上。
即，在本申请实施例中，通过所述一支撑杆12给予了相邻的两个支撑梁11一定的支撑力，由此可以进一步保证所述左心耳封堵器1的稳固性。特别的，避免发生不规则变形以及侧向滑移。
进一步的，所述支撑杆12从所述第一毂10至所述第三位置121的长度小于所述支撑梁11从所述第一毂10到所述第一位置110的长度。由此，可以使得所述支撑杆12的结构更加稳定，从而给予所述支撑梁11更好的支撑力。
优选的，所述支撑杆12的第一端120、第二端122及第三端123呈一“Y”字形，即所述支撑杆12的第一端120、第二端122及第三端123呈一个对称型结构。“Y”字形结构具有极佳的稳定性与可靠性，从而也使得支撑杆12具有极佳的稳定性与可靠性。进一步的，所述第三位置121位于所述支撑杆12沿径向的1/5到4/5距离之间的位置处，由此能够便于管材切割形成所述支撑杆12以及后续的扩张定型。
请继续参考图1至图3，在本申请实施例中，所述全部或部分的支撑梁11上包括一倒钩13，和/或所述全部或部分的左支撑梁111及右支撑梁112上包括一倒钩13。通过所述倒钩13可以提高所述左心耳封堵器1在左心耳上的固定的牢固性。优选的，所述倒钩13通过切割工艺与所述支撑梁11、左支撑梁111和/或右支撑梁112一体化成型，由此，既能简化工艺、又能保证结构的可靠性。
如图1所示，在本申请实施例中，同一支撑梁11所形成的左支撑梁111及右支撑梁112的远端连接。由此，可以提高支撑梁11在周向上的稳定性，进而 提高所述左心耳封堵器1的稳定性与可靠性。
请参考图4，其为本发明实施例一的左心耳封堵器的局部放大示意图。在本申请实施例中，同一支撑梁11所形成的左支撑梁111及右支撑梁112的远端连接之后，继续延伸，到达左支撑梁111及右支撑梁112的末端。所述左支撑梁111及右支撑梁112的远端连接之后至末端之间，所述左支撑梁111及右支撑梁112的远端向近端弯折以形成一锚状物14。通过所述锚状物14可以使得所述左心耳封堵器1牢固的固定于左心耳上。
请继续参考图4，优选的，所述远端的弯折点115至末端116的长度大于所述远端连接点114至末端的长度116。由此可知，所述锚状物14的弯折程度比较大，并通过远端连接点114的设置，使锚状物14的结构更加稳定，从而可以提高其对于左心耳的抓钩能力，即可以提高所述左心耳封堵器1在左心耳上的固定的牢固性。此外，较佳的，所述远端的连接点114至末端116的长度为1mm～3mm，所述远端的弯折点115至远端连接点114的长度小于3mm。
在本申请实施例中，所述锚状物在所述左支撑梁111及右支撑梁112的远端连接后形成，由此，所述远端连接点114可以成为所述锚状物抓钩的终止点，因此该抓钩不会因为过长而刺穿心脏组织，从而免于所述锚状物对于左心耳的伤害。
在本申请实施例中，所述左心耳封堵器1可以一体化成型。具体的，可以通过对一根管材进行切割形成第一毂10、支撑梁11、支撑杆12及锚状物14等部件实现。一体化成型可以简化生产工艺流程，节约人力和材料等经济成本。
进一步的，所述左心耳封堵器1至少部分覆盖一生物相容膜。
上述左心耳封堵器1可以以如下方式使用：
利用推送器通过导管建立的通道把左心耳封堵器导向导管的末端，在末端释放。释放时候，左心耳封堵器1从鞘管出来，锚状物在左心耳腔壁固定定位好以后，支撑梁11和支撑杆12扩张，扣在左心耳腔壁，充分贴合，达到最佳的封堵效果。在回收时，方向相反，带动锚状物从左心耳的腔壁上自然回收。
具体的，可参考图5，其中，图5为本发明实施例一的左心耳封堵器在左心耳上的状态示意图。当所述左心耳封堵器1被释放到左心耳7中时，所述左心耳封堵器1扩张开来，此时，倒钩13及锚状物14固定于所述左心耳7上。
【实施例二】
请参考图6和图7，其中，图6为本发明实施例二的左心耳封堵器的立体结构示意图；图7为是本发明实施例二的左心耳封堵器的剖视示意图。如图6和图7所示，所述左心耳封堵器3包括多个支撑梁31，所述支撑梁31分布于一第一毂30的外侧并向外延伸，所述支撑梁31于第一位置310处分开为一左支撑梁311及一右支撑梁312，相邻所述支撑梁31的左支撑梁311及右支撑梁312于第二位置313处连接并向远侧延伸形成一远端；所述左心耳封堵器3的相邻支撑梁31中间包括一支撑杆32。
进一步的，所述支撑杆32的第一端320连接所述第一毂30的外侧，所述支撑杆32的第一端320向外延伸，并于第三位置321处分开为一第二端322及一第三端323。进一步的，所述第二端322固定于所述左支撑梁311的第一位置310及第二位置313之间，所述第三端323固定于所述右支撑梁312的第一位置310及第二位置313之间。所述第二端322和第三端323分别固定于相邻的两个支撑梁31上。
所述全部或部分的支撑梁31上包括一倒钩33，和/或所述全部或部分的左支撑梁311及右支撑梁312上包括一倒钩33。同一支撑梁31所形成的左支撑梁311及右支撑梁312的远端连接。所述左支撑梁311及右支撑梁312的远端向近端弯折以形成一锚状物34。
上述结构均与实施例一相同，因此本实施例二对此不再赘述。
本实施例二与实施例一的差别在于，所述左心耳封堵器3还包括第二毂35。具体的，所述远端向内延伸并形成一第二毂35。请继续参考图6，具体的，所述左支撑梁311和右支撑梁312的远端均向内延伸，从而形成第二毂35。进一步的，所述第一毂30与所述第二毂35共轴。由此，能够使得所述左心耳封堵器3具有极佳的对称性，从而便于所述左心耳封堵器3的释放与回收。
上述左心耳封堵器3可以以如下方式使用：
利用推送器通过导管建立的通道把左心耳封堵器导向导管的末端，在末端释放。释放时候，左心耳封堵器3从鞘管出来，锚状物在左心耳腔壁固定定位好以后，支撑梁31和支撑杆32扩张，扣在左心耳腔壁，充分贴合，达到最佳的封堵效果。在回收时，方向相反，带动锚状物从左心耳的腔壁上自然回收。由于本实施例二中的左心耳封堵器3远端向内延伸并形成一第二毂35，因此其具有更好的回收与释放能力。
在本实施例二中，所述远端可以沿着朝向所述近端的方向延伸并形成一第二毂35；在本申请的其他实施例中，所述远端也可以沿着朝向所述远端的方向延伸并形成一第二毂35，具体如图8所示。在前述两种情况下，所述第一毂30的凸起与第二毂35的凸起相同。在本申请的其他实施例中，所述第一毂30的凸起与第二毂35的凸起相反，如图9所示。
【实施例三】
请参考图10，其为本发明实施例三的左心耳封堵器的立体结构示意图。如图10所示，所述左心耳封堵器4包括多个支撑梁41，所述支撑梁41分布于一第一毂40的外侧并向外延伸，所述支撑梁41于第一位置410处分开为一左支撑梁411及一右支撑梁412，相邻所述支撑梁41的左支撑梁411及右支撑梁412于第二位置413处连接并向远侧延伸形成一远端；所述左心耳封堵器4的相邻支撑梁41中间包括一支撑杆42。所述远端向内延伸并形成一第二毂45。
进一步的，所述支撑杆42的第一端420连接所述第一毂40的外侧，所述支撑杆42的第一端420向外延伸，并于第三位置421处分开为一第二端422及一第三端423。进一步的，所述第二端422固定于所述左支撑梁411的第一位置410及第二位置413之间，所述第三端423固定于所述右支撑梁412的第一位置410及第二位置413之间。所述第二端422和第三端423分别固定于相邻的两个支撑梁41上。
所述全部或部分的支撑梁41上包括一倒钩43，和/或所述全部或部分的左支撑梁411及右支撑梁412上包括一倒钩43。
本实施例三与实施例二的差别在于，在本实施例三中，同一支撑梁41所形成的左支撑梁411及右支撑梁412的远端不再连接而直接沿径向向外突起以形成一锚状物44。在本实施例三中，通过远端沿径向向外突起以形成一锚状物44使得左心耳封堵器4可牢固的固定于左心耳上。
【实施例四】
请参考图11，其为本发明实施例四的左心耳封堵器的剖视示意图。本实施例四与实施例一的结构均相同，仅有的差别在于，本实施例四中的支撑梁及支撑杆为双层镍钛合金结构。由此使得所述左心耳封堵器5具有更好的质量与稳定性。
上述实施例二和实施例三中的左心耳封堵器都具有第一毂、第二毂以及连 接第一毂和第二毂的笼状结构(支撑梁和支撑杆组成了密集的网格，这些将第一毂和第二毂连接起来的网格形成了笼状结构)，属于笼状闭塞型左心耳封堵器。
下面以图12所示的笼状闭塞型左心耳封堵器为例，详细说明左心耳封堵器的输送系统的结构和工作原理。参考图12中的左心耳封堵器的立体结构示意图。图12可具有与前述图6所示的实施例二中的左心耳封堵器相同或相似的结构，为了简化，仅标出第一毂30，锚状物34，第二毂35和笼状结构36。如图12所示，所述左心耳封堵器3包括：第一毂30、第二毂35以及连接第一毂30和第二毂35的笼状结构36，所述笼状结构36上具有锚状物34。优选的，所述笼状结构36上具有多排锚状物34，从而可以使得所述左心耳封堵器3能够更易于固定到左心耳上，并且能够更加稳定、可靠地固定到左心耳上。
需知的，笼状闭塞型左心耳封堵器还可以有其他结构形式，本发明左心耳封堵器的输送系统对此均适用；此外，左心耳封堵器中除了最典型的笼状闭塞型左心耳封堵器之外，还有其他结构形式，本发明对此同样适用。
【实施例五】
请参考图13，其为本发明实施例五的左心耳封堵器的输送系统的结构示意图。如图13所示，所述输送系统6包括：第一输送部60以及位于所述第一输送部60内侧的第二输送部61。其中，所述第一输送部60可以与所述(左心耳封堵装置3的)第一毂30分开或连接，所述第二输送部61可以与所述(左心耳封堵装置3的)第二毂35分开或连接。具体的，在入鞘前，所述第一输送部60与左心耳封堵器3的第一毂30连接；所述第二输送部61与所述左心耳封堵器3的第二毂35连接，由此可以使得所述左心耳封堵器3收拢，然后再将所述左心耳封堵器3入鞘，如此设计可以避免左心耳封堵器3在鞘管内长度过长的问题。
具体的，请参考图14，其为本发明实施例五的左心耳封堵器的输送系统在左心耳封堵器未释放时的状态示意图。如图14所示，在本申请实施例中，所述输送系统6还包括一鞘管62，所述第一输送部60位于所述鞘管62内侧。此时，所述输送系统6未释放所述左心耳封堵器3，所述第一输送部60与所述第一毂30连接，所述第二输送部61与所述第二毂35连接。进一步的，所述第一毂30与所述第二毂35相接合，从而使得所述左心耳封堵器3聚拢在一起，相对于所 述第一毂30与所述第二毂35在所述鞘管62内相分离的情况，大大减小了左心耳封堵器3在鞘管中的长度，由此也可便于所述左心耳封堵器3的释放。
请继续参考图14，所述左心耳封堵器3的所述笼状结构34经折叠形成一第一部分360和一第二部分361；所述第一部分360的一端连接所述第一毂30，另一端连接所述第二部分361的一端，所述第二部分361的另一端连接所述第二毂35。在本申请实施例中，所述左心耳封堵器3的第一部分360和第二部分361上均可以设置有若干锚状物34。所述输送系统6未释放所述左心耳封堵器3时，所述第二部分361位于所述第一部分360内侧。即所述第一部分360与所述第二部分361在竖直方向上重叠了，由此也就大大减小了所述左心耳封堵器3在鞘管中的长度。由于该左心耳封堵器3位于该输送系统6内部时呈折叠状态，位于第二部分361上的锚状物34位于内部空间中，在进入鞘管62以及在鞘管62中移动时，不会接触鞘管62，也不会存在划伤鞘管62的情况。
接着请参考图15至图17，其示出了对于左心耳封堵器3的释放过程。
首先，如图15所示，随着第一输送部60和第二输送部61自鞘管62中推出，所述左心耳封堵器3(可相应参考图6和图12)也慢慢自鞘管62中出来。在此，所述左心耳封堵器3首先自鞘管62中出来部分为第一部分360及其上的锚状物34。此时，输送系统6仍旧与所述左心耳封堵器3连接，即所述输送系统6依然能够控制所述左心耳封堵器3，医生可以调节锚状物34对于左心耳的固定，从而实现重复定位。
接着，如图16所示，第二输送部61继续自鞘管62中推出(此时第一输送部60可停止自鞘管62中推出或者相对缓慢自鞘管62中推出)。此时，所述左心耳封堵器3中的其他部分也自鞘管62中出来。由于此时第一毂30及第二毂35仍旧与第一输送部360及第二输送部361连接着，即所述左心耳封堵器3的状态仍旧是(由医生)可控的，因此此时医生仍旧可以调节锚状物34对于左心耳的固定，实现重复定位。
接着如图17所示，当医生已将左心耳封堵器3固定于左心耳的合适位置上时，其便可以释放所述左心耳封堵器3。具体包括：使得所述第二输送部61与所述第二毂35分开，所述第一输送部60与所述第一毂30分开。此时，所述左心耳封堵器3也便不可再被重复定位了。
请继续参考图17，在本申请实施例中，所述第二输送部61与所述第二毂 35通过螺纹螺母结构连接，通过拧紧与旋松所述第二输送部61与所述第二毂35的螺纹螺母结构便可实现所述第二输送部61与所述第二毂35的连接与分开。在本申请的其他实施例中，所述第二输送部61与所述第二毂35也可通过其他连接方式连接，例如，外花键内花键结构连接或者卡扣结构连接。
在本申请实施例中，所述第一毂30与所述第二毂35具体通过如下方式相接合：所述第一毂30的远端包括一台阶300，当所述第一毂30与所述第二毂35相接合时，所述第二毂35的近端位于所述台阶300上。所述第一输送部60与所述第一毂30通过如下方式连接：所述第一毂30的近端包括一凹槽301，所述第一输送部60的远端位于所述凹槽301内。由此，简便的便实现了所述第一输送部60与所述第一毂30连接；同时，释放时，所述第一输送部60与所述第一毂30也可很方便的分开。
通过上述过程后，所述左心耳封堵器3便可固定在左心耳7上(可相应参考图18及图6)，从而实现对于所述左心耳7的封堵。
接着，请参考图19和图20，其中，图19为本发明实施例五的限位装置的结构示意图；图20为本发明实施例五的限位装置固定第一输送部和第二输送部的结构示意图。在本申请实施例中，所述输送系统6还包括一限位装置63，用于固定所述第一输送部60及第二输送部61。进一步的，所述限位装置63包括一夹持部630以及一施力部631，所述夹持部630包括一凸起块，所述凸起块通过位于所述第一输送部60上的卡槽64，夹持所述第二输送部61。通过所述限位装置63可以很方便的控制所述第一输送部60及第二输送部61，以对所述第一输送部60及第二输送部61进行整体推送等操作。所述施力部631上还连接一弹簧632，用于固定夹持部630。
接着，请继续参考图13，优选的，所述输送系统6还包括一手柄65，在本申请实施例中，所述手柄65位于所述第一输送部60的近端。通过夹紧所述手柄65并进行推送，也可以便于所述第一输送部60和所述第二输送部61在所述鞘管62内的推进，并最终实现对于所述左心耳封堵器3的释放。优选的，所述手柄65上具有一可视化标志，所述可视化标志可以为螺纹螺母结构的旋转识别标志，在此即为所述第二输送部61与所述第二毂35的螺纹螺母结构的旋转识别标志，从而可以方便的识别螺纹的左右旋向，便于实现所述第二输送部61与所述第二毂35之间的连接与分开。
在本申请实施例中，可通过如下过程实现对于所述左心耳封堵器3的释放：
由手柄65或者限位装置63将所述第一输送部60和所述第二输送部61在所述鞘管62内进行推进；接着，释放所述左心耳封堵器3的第一部分(通过所述第一输送部60和所述第二输送部61远端推送出鞘管62可实现)，此时可以进行多次重复定位和调节；在所述第一部分的定位完成后，接着松开限位装置63，旋松第二输送部61与第二毂35的螺纹螺母结构，使得所述第二输送部61与第二毂35分开，此时，所述左心耳封堵器3便可扣在左心耳7上；接着回拉第一输送部60，即可释放所述左心耳封堵器3。
综上可见，在本实施例提供的左心耳封堵器的输送系统中，可以避免左心耳封堵器在鞘管内长度过长的问题；同时，在释放时能够实现重复定位，可见更好的实现了左心耳封堵器的入鞘或者释放。
【实施例六】
请参考图21至图23，其示出了本发明实施例六的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图。如图所示，所述输送系统8包括：第一输送部80以及位于所述第一输送部80内的第二输送部81。其中，所述第一输送部80与所述(左心耳封堵器3的)第一毂30分开或连接，所述第二输送部81与所述(左心耳封堵器3的)第二毂35分开或连接。通过所述输送系统8，具体的，在入鞘前，所述第一输送部80与左心耳封堵器3的第一毂80连接；所述第二输送部81与所述左心耳封堵器3的第二毂35连接，由此可以使得所述左心耳封堵器3收拢，然后再将所述左心耳封堵器3入鞘，便可以避免左心耳封堵器3在鞘管内长度过长的问题。
在本实施例二中，所述第二输送部81与所述第二毂35的连接方式与实施例一相同，同样通过螺纹螺母结构连接。
在本实施例二中，所述第一输送部80与所述第一毂31的连接方式与实施例一不同，在此，所述第一输送部80与所述第一毂31也通过螺纹螺母结构连接。
进一步的，在本实施例二中，所述第一输送部80及第二输送部81的近端均设置有手柄83，其中，所述第二输送部81近端的手柄83可以单独实现对于所述第二输送部81的推送。进一步的，所述第一输送部80及第二输送部81的手柄83上均设置有可视化标志。在本实施例二中，所述第一输送部80近端的 手柄83上示出了第一输送部80与第一毂31的螺纹螺母结构的旋转识别标志；所述第二输送部81近端的手柄83上示出了第二输送部81与第二毂35的螺纹螺母结构的旋转识别标志，由此可以很方便的实现所述第一输送部80与所述第一毂31的连接与分开，所述第二输送部81与所述第二毂35的连接与分开。
进一步的，所述输送系统8也可包括鞘管、限位装置等，此部分结构(包括本实施例二未描述的其他结构)可相应参考实施例一，本实施例二对此不再赘述。
请继续参考图21至图23，在本申请实施例中，可通过如下过程实现对于所述左心耳封堵器3的释放：
由手柄83或者限位装置(图中未示出)将所述第一输送部80和所述第二输送部81在所述鞘管82内进行推进；接着，释放所述左心耳封堵器3的第一部分(通过所述第一输送部80和所述第二输送部81远端推送出鞘管82可实现)，此时可以进行多次重复定位和调节；在所述第一部分的定位完成后，接着松开限位装置，旋松第二输送部81与第二毂35的螺纹螺母结构，使得所述第二输送部81与第二毂35分开，此时，所述左心耳封堵器3便可扣在左心耳上；接着旋松第一输送部80与第一毂35的螺纹螺母结构，即可释放所述左心耳封堵器3。
综上可见，在本实施例提供的左心耳封堵器的输送系统中，可以避免左心耳封堵器在鞘管内长度过长的问题；同时，在释放时能够实现重复定位，可见更好的实现了左心耳封堵器的入鞘或者释放。
【实施例七】
请参考图24，其为本发明实施例七的左心耳封堵器的输送系统在左心耳封堵器部分释放时的状态示意图。如图24所示，在本实施例七中，所述输送系统9包括：第一输送部90以及位于所述第一输送部90内的第二输送部91。其中，所述第一输送部90与所述(左心耳封堵器3的)第一毂30分开或连接，所述第二输送部91与所述(左心耳封堵器3的)第二毂35分开或连接。通过所述输送系统9，具体的，在入鞘前，所述第一输送部90与左心耳封堵器3的第一毂30连接；所述第二输送部91与所述左心耳封堵器3的第二毂35连接，由此可以使得所述左心耳封堵器3收拢，然后再将所述左心耳封堵器3入鞘，便可以避免左心耳封堵器3在鞘管内长度过长的问题。
在本实施例七中，所述第一输送部90的远端呈喇叭状。在此，所述第二输送部91与所述第二毂35通过螺纹螺母结构连接；所述第一输送部90与所述第一毂30之间的连接通过所述第一输送部90顶住所述第一毂30实现。由于所述第一输送部90的远端呈喇叭状，在所述第二输送部91与所述第二毂35通过螺纹螺母结构连接之后，所述第一输送部90便可顶住所述第一毂30，从而便可使得所述左心耳封堵器3收拢。
同样的，所述输送系统9也可包括鞘管、限位装置、手柄等，此部分结构(包括本实施例三未描述的其他结构)可相应参考实施例一，本实施例三对此不再赘述。
所述左心耳封堵器3可通过如下过程释放：
将所述第一输送部90和所述第二输送部91在所述鞘管92内进行推进；接着，释放所述左心耳封堵器3的第一部分(通过所述第一输送部90和所述第二输送部91远端推送出鞘管92可实现)，此时可以进行多次重复定位和调节；在所述第一部分的定位完成后，旋松第二输送部91与第二毂35的螺纹螺母结构，使得所述第二输送部91与第二毂35分开，此时，所述左心耳封堵器3便可扣在左心耳上；接着回拉第一输送部90，即可释放所述左心耳封堵器3。
综上可见，在本实施例提供的左心耳封堵器的输送系统中，可以避免左心耳封堵器在鞘管内长度过长的问题；同时，在释放时能够实现重复定位，可见更好的实现了左心耳封堵器的入鞘或者释放。
【实施例八】
在本实施例八中，所述输送系统包括：第一输送部以及位于所述第一输送部内的第二输送部。其中，所述第一输送部与所述(左心耳封堵器3的)第一毂30分开或连接，所述第二输送部与所述(左心耳封堵器3的)第二毂35分开或连接。通过所述输送系统，具体的，在入鞘前，所述第一输送部与左心耳封堵器3的第一毂30连接；所述第二输送部与所述左心耳封堵器3的第二毂35连接，由此可以使得所述左心耳封堵器3收拢，然后再将所述左心耳封堵器3入鞘，便可以避免左心耳封堵器3在鞘管内长度过长的问题。
本实施例八与实施例五、实施例六或者实施例七的主要差别在于，所述第一毂可与所述第二毂连接。
具体可参考图25和图26，其中，图25为本发明实施例八的左心耳封堵器 的输送系统在左心耳封堵器全部释放时的状态示意图；图26为本发明实施例八的左心耳封堵器的输送系统在左心耳封堵器全部释放时的另一状态示意图。如图25和图26所示，所述左心耳封堵器在全部释放后，所述第一毂30与所述第二毂35可部分或者全部连接。通过所述第一毂30与所述第二毂35部分或者全部连接以及连接的位置，可以使得所述左心耳封堵器更好的适应不同的左心耳。具体的，当所述第二毂35与所述第一毂30的上部连接(如图25所示)时，所述左心耳封堵器能更好的适应形状较小的左心耳；当所述第二毂35与所述第一毂30的下部连接(如图26所示)时，所述左心耳封堵器能更好的适应形状较大的左心耳；此外，当所述第二毂35与所述第一毂30分开(如图27所示)时，所述左心耳封堵器能更好的适应形状更大的左心耳。
其中，所述第一毂30与所述第二毂35可通过卡扣结构连接或者外花键内花键结构连接等。例如，所述第一毂30与所述第二毂35通过卡扣结构连接(可相应参考图25至图27)，其中，所述第一毂30设置内卡扣结构，所述第二毂35设置外卡扣结构；又如，所述第一毂30与所述第二毂35通过外花键内花键结构连接(其中，外花键内花键结构及两者连接下的状态可相应参考图28至图30)，其中，所述第一毂30设置内花键结构，所述第二毂35设置外花键结构。
进一步的，此时，所述第一毂30可通过外螺纹螺母结构与所述第一输送部连接，所述第二毂35可通过内螺纹螺母与所述第二输送部连接。
综上可见，在本发明实施例提供的左心耳封堵器的输送系统中，所述输送系统包括第一输送部以及位于所述第一输送部内的第二输送部，在入鞘前，第一输送部与左心耳封堵器的第一毂连接；第二输送部与所述左心耳封堵器的第二毂连接，由此可以使得所述左心耳封堵器收拢，然后再将所述左心耳封堵器入鞘，便可以避免左心耳封堵器在鞘管内长度过长的问题。在释放时，左心耳封堵器中设置有锚状物的第二部分先释放，此时可以重复定位直至达到合适的固定位置，然后再释放左心耳封堵器的第二毂及第一毂。可见，本发明提供的左心耳封堵器的输送系统能够更好的实现左心耳封堵器的入鞘或者释放。
上述描述仅是对本发明较佳实施例的描述，并非对本发明范围的任何限定，本发明领域的普通技术人员根据上述揭示内容做的任何变更、修饰，均属于权利要求书的保护范围。

Claims (30)

  1. 一种左心耳封堵器，其特征在于，所述左心耳封堵器包括多个支撑梁，所述支撑梁分布于一第一毂的外侧并向外延伸，所述支撑梁于第一位置处分开为一左支撑梁及一右支撑梁，相邻所述支撑梁的左支撑梁及右支撑梁于第二位置处连接并向远侧延伸形成一远端；所述左心耳封堵器的相邻支撑梁中间包括一支撑杆。
  2. 如权利要求1所述的左心耳封堵器，其特征在于，所述支撑杆的第一端连接所述第一毂的外侧，所述支撑杆的第一端向外延伸，并于第三位置处分开为一第二端及一第三端。
  3. 如权利要求2所述的左心耳封堵器，其特征在于，所述第二端固定于所述左支撑梁的第一及第二位置之间，所述第三端固定于所述右支撑梁的第一及第二位置之间。
  4. 如权利要求2所述的左心耳封堵器，其特征在于，所述第二端和第三端分别固定于相邻的两个支撑梁上。
  5. 如权利要求2所述的左心耳封堵器，其特征在于，所述支撑杆从所述第一毂至所述第三位置的长度小于所述支撑梁从所述第一毂到所述第一位置的长度。
  6. 如权利要求2所述的左心耳封堵器，其特征在于，所述支撑杆的第一端、第二端及第三端呈一“Y”字形。
  7. 如权利要求2所述的左心耳封堵器，其特征在于，所述全部或部分的支撑梁上包括一倒钩，和/或所述全部或部分的左支撑梁及右支撑梁上包括一倒钩。
  8. 如权利要求1所述的左心耳封堵器，其特征在于，同一支撑梁所形成的左支撑梁及右支撑梁的远端连接。
  9. 如权利要求8所述的左心耳封堵器，其特征在于，所述远端向近端弯折以形成一锚状物。
  10. 如权利要求9所述的左心耳封堵器，其特征在于，所述远端的弯折点至末端的长度大于所述远端连接点至末端的长度。
  11. 如权利要求1所述的左心耳封堵器，其特征在于，所述远端向内延伸 并形成一第二毂。
  12. 如权利要求1所述的左心耳封堵器，其特征在于，所述远端沿径向突起以形成一锚状物。
  13. 如权利要求11所述的左心耳封堵器，其特征在于，所述第一毂与所述第二毂共轴。
  14. 如权利要求13所述的左心耳封堵器，其特征在于，所述第一毂沿轴向凸起的方向与第二毂沿轴向凸起的方向相同或相反。
  15. 如权利要求1所述的左心耳封堵器，其特征在于，所述左心耳封堵器至少部分覆盖一生物相容膜。
  16. 如权利要求1所述的左心耳封堵器，其特征在于，相邻所述支撑梁之间的角度为45°。
  17. 一种左心耳封堵器的输送系统，用于释放一左心耳封堵器，其特征在于，所述输送系统包括第一输送部以及位于所述第一输送部内的第二输送部；
    所述第一输送部用于与所述左心耳封堵器的第一毂分开或连接；
    所述第二输送部用于与所述左心耳封堵器的第二毂分开或连接。
  18. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述输送系统未释放所述左心耳封堵器时，所述第一毂与所述第二毂相接合。
  19. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述输送系统还包括一鞘管，所述第一输送部位于所述鞘管内部。
  20. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述输送系统还包括一限位装置，用于固定所述第一输送部及第二输送部。
  21. 如权利要求20所述的左心耳封堵器的输送系统，其特征在于，所述限位装置包括一夹持部以及一施力部，所述夹持部部分或全部通过位于所述第一输送部上的卡槽，夹持所述第二输送部。
  22. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述输送系统还包括一手柄，所述手柄位于所述第一输送部和/或所述第二输送部的近端，所述手柄上具有一可视化标志。
  23. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述左心耳封堵器包括一第一部分和一第二部分；所述第一部分的一端连接所述第一毂，另一端连接所述第二部分的一端，所述第二部分的另一端连接所述第二 毂。
  24. 如权利要求23所述的左心耳封堵器的输送系统，其特征在于，所述输送系统未释放所述左心耳封堵器时，所述第二部分位于所述第一部分内。
  25. 如权利要求23所述的左心耳封堵器的输送系统，其特征在于，所述第一部分和/或所述第二部分设置若干锚状物。
  26. 如权利要求18所述的左心耳封堵器的输送系统，其特征在于，所述第一毂的远端包括一台阶，当所述第一毂与所述第二毂相接合时，所述第二毂的近端位于所述台阶上。
  27. 如权利要求26所述的左心耳封堵器的输送系统，其特征在于，所述第一毂的近端包括一凹槽，所述第一输送部的远端位于所述凹槽内。
  28. 如权利要求26所述的左心耳封堵器的输送系统，其特征在于，所述第一输送部的远端呈喇叭状。
  29. 如权利要求18所述的左心耳封堵器的输送系统，其特征在于，当所述第一毂与所述第二毂相接合时，所述第一毂与第二毂通过外花键内花键结构连接或者卡扣结构连接。
  30. 如权利要求17所述的左心耳封堵器的输送系统，其特征在于，所述第一输送部与所述第一毂通过螺纹螺母结构连接、外花键内花键结构连接或者卡扣结构连接和/或所述第二输送部与所述第二毂通过螺纹螺母结构连接、外花键内花键结构连接或者卡扣结构连接。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020074738A1 (en) * 2018-10-11 2020-04-16 National University Of Ireland, Galway A device for implantation in a left atrial appendage of the heart
WO2020144283A1 (de) * 2019-01-10 2020-07-16 Ls Medcap Gmbh Okkludereinführsystem
WO2020144284A1 (de) * 2019-01-10 2020-07-16 Ls Medcap Gmbh Okkluder, system aus okkluder und einführkatheter und verfahren zur bereitstellung des systems

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3134010B1 (en) 2014-04-25 2020-04-22 Flow Medtech, LLC Left atrial appendage occlusion device
AU2015317365A1 (en) 2014-09-19 2017-05-11 Flow Medtech, Inc. Left atrial appendage occlusion device delivery system
WO2020198259A1 (en) 2019-03-25 2020-10-01 Laminar, Inc. Devices and systems for treating the left atrial appendage
US12303116B2 (en) 2020-03-24 2025-05-20 Laminar, Inc. Devices, systems, and methods for occluding cavities within the body
WO2023038929A1 (en) 2021-09-08 2023-03-16 Boston Scientific Scimed, Inc. Occlusive implant with multi-sharpness split tip soft tissue anchors
EP4498948A1 (en) 2022-03-28 2025-02-05 Laminar, Inc. Devices, systems, and methods for transseptal puncture

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040093017A1 (en) * 2002-11-06 2004-05-13 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
CN102895008A (zh) * 2012-09-28 2013-01-30 乐普（北京）医疗器械股份有限公司 医用封堵器及其输送系统
CN204147142U (zh) * 2014-09-16 2015-02-11 徐州亚太科技有限公司 一种组合式左心耳封堵器
CN104905840A (zh) * 2015-06-12 2015-09-16 上海申淇医疗科技有限公司 一种左心耳封堵器骨架
CN204971418U (zh) * 2015-07-28 2016-01-20 杭州德诺科技有限公司 一种左心耳封堵器

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9861346B2 (en) * 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US20110208233A1 (en) * 2004-01-22 2011-08-25 Mcguckin Jr James F Device for preventing clot migration from left atrial appendage
DE102008015781B4 (de) * 2008-03-26 2011-09-29 Malte Neuss Vorrichtung zum Verschluss von Defekten im Gefäßsystem
CA2958333A1 (en) 2009-06-17 2010-12-23 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9351716B2 (en) * 2009-06-17 2016-05-31 Coherex Medical, Inc. Medical device and delivery system for modification of left atrial appendage and methods thereof
US9649115B2 (en) 2009-06-17 2017-05-16 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9693781B2 (en) 2009-06-17 2017-07-04 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US20110082495A1 (en) 2009-10-02 2011-04-07 Ruiz Carlos E Apparatus And Methods For Excluding The Left Atrial Appendage
WO2013159065A1 (en) 2012-04-20 2013-10-24 Paul Lubock Expandable occlusion devices and methods of use
CN103099652B (zh) 2013-02-19 2015-08-12 湖南埃普特医疗器械有限公司 一种左心耳封堵装置以及一种输送系统
CN205758647U (zh) 2016-05-31 2016-12-07 上海微创医疗器械（集团）有限公司 左心耳封堵装置的输送系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040093017A1 (en) * 2002-11-06 2004-05-13 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
CN102895008A (zh) * 2012-09-28 2013-01-30 乐普（北京）医疗器械股份有限公司 医用封堵器及其输送系统
CN204147142U (zh) * 2014-09-16 2015-02-11 徐州亚太科技有限公司 一种组合式左心耳封堵器
CN104905840A (zh) * 2015-06-12 2015-09-16 上海申淇医疗科技有限公司 一种左心耳封堵器骨架
CN204971418U (zh) * 2015-07-28 2016-01-20 杭州德诺科技有限公司 一种左心耳封堵器

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020074738A1 (en) * 2018-10-11 2020-04-16 National University Of Ireland, Galway A device for implantation in a left atrial appendage of the heart
US12167855B2 (en) 2018-10-11 2024-12-17 University of Galway Device for implantation in a left atrial appendage of the heart
EP4101397A2 (de) 2019-01-10 2022-12-14 Qatna Medical GmbH Okkludereinführsystem und einführeinheit
EP4101397A3 (de) * 2019-01-10 2023-01-11 Qatna Medical GmbH Okkludereinführsystem und einführeinheit
DE102019100531B4 (de) 2019-01-10 2021-08-19 Qatna Medical GmbH Okkludereinführsystem und Einführeinheit
CN113286550A (zh) * 2019-01-10 2021-08-20 卡特纳医疗有限公司 封堵器插入系统
CN113316423A (zh) * 2019-01-10 2021-08-27 卡特纳医疗有限公司 封堵器、由封堵器和插入导管构成的系统以及用于提供该系统的方法
JP2022518166A (ja) * 2019-01-10 2022-03-14 カトナ メディカル ゲーエムベーハー オクルーダ、オクルーダと挿入カテーテルとで構成されるシステム、及びシステムを提供する方法
WO2020144284A1 (de) * 2019-01-10 2020-07-16 Ls Medcap Gmbh Okkluder, system aus okkluder und einführkatheter und verfahren zur bereitstellung des systems
DE102019100530B4 (de) * 2019-01-10 2021-05-06 Qatna Medical GmbH Okkluder und System zur Einführung eines Okkluders
US11690630B2 (en) 2019-01-10 2023-07-04 Qatna Medical GmbH Occluder insertion system
EP4215128A1 (de) * 2019-01-10 2023-07-26 Qatna Medical GmbH Okkluder, system aus okkluder und einführkatheter und verfahren zur bereitstellung des systems
JP7362747B2 (ja) 2019-01-10 2023-10-17 カトナ メディカル ゲーエムベーハー オクルーダ、オクルーダと挿入カテーテルとで構成されるシステム、及びシステムを提供する方法
CN113286550B (zh) * 2019-01-10 2024-06-11 卡特纳医疗有限公司 封堵器插入系统
CN113316423B (zh) * 2019-01-10 2024-08-06 卡特纳医疗有限公司 封堵器、由封堵器和插入导管构成的系统以及用于提供该系统的方法
WO2020144283A1 (de) * 2019-01-10 2020-07-16 Ls Medcap Gmbh Okkludereinführsystem

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