WO2017153865A1 - Échantillonneur biologique, collecteur et récipient de stockage - Google Patents

Échantillonneur biologique, collecteur et récipient de stockage Download PDF

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Publication number
WO2017153865A1
WO2017153865A1 PCT/IB2017/051119 IB2017051119W WO2017153865A1 WO 2017153865 A1 WO2017153865 A1 WO 2017153865A1 IB 2017051119 W IB2017051119 W IB 2017051119W WO 2017153865 A1 WO2017153865 A1 WO 2017153865A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
punch
sample
sample collector
driver
Prior art date
Application number
PCT/IB2017/051119
Other languages
English (en)
Inventor
Rory BLADEN
Roy Victor Bladen
Michael Stuart Gardner
Original Assignee
Snpshot Trustee Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snpshot Trustee Limited filed Critical Snpshot Trustee Limited
Priority to EP17762607.4A priority Critical patent/EP3426162A4/fr
Priority to CA3031581A priority patent/CA3031581A1/fr
Priority to MX2018010844A priority patent/MX2018010844A/es
Priority to KR1020187028915A priority patent/KR20180131564A/ko
Priority to US16/083,306 priority patent/US20190094112A1/en
Priority to JP2018547350A priority patent/JP2019507881A/ja
Priority to RU2018135230A priority patent/RU2018135230A/ru
Priority to AU2017230983A priority patent/AU2017230983A1/en
Priority to CN201780027569.9A priority patent/CN109414256A/zh
Priority to BR112018068083A priority patent/BR112018068083A2/pt
Publication of WO2017153865A1 publication Critical patent/WO2017153865A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/288—Filter punches

Definitions

  • BIOLOGICAL SAMPLER BIOLOGICAL SAMPLER, COLLECTOR AND STORAGE CONTAINER
  • the present invention relates to improvements in or relating to biological sample collecting.
  • tissue means any part of a living thing, particularly any part made up of similar cells, or any part or parts that perform a similar function.
  • Tissue preferably refers to any form of biological sample, from plants and animals particularly, including pigs, goats, cattle, sheep, poultry, and fish.
  • Biological samples may include for example, animal tissue such as flesh, blood, hair, fur, saliva, sweat, urine, etc, or plant tissue such as leaves, bark, roots or wood, or any other part of a plant or animal but particularly those that are made up of similar cells, or which perform a similar function.
  • animal tissue such as flesh, blood, hair, fur, saliva, sweat, urine, etc
  • plant tissue such as leaves, bark, roots or wood, or any other part of a plant or animal but particularly those that are made up of similar cells, or which perform a similar function.
  • the present invention may be used at least for either or both of production animals and companion animals. It is anticipated that production animals may include but not be limited to bovine, pigs, deer and sheep. Further it is anticipated that companion animals may include but not be limited to horses, cats and dogs.
  • the present invention may be broadly be said to be, as an assembled elongate string, a sample collector and sample collector driver to drive at least the sample collector through an item to be sampled along a sampling axis aligned to the elongate direction of the string,
  • the sample collector comprising : a punch presenting at one end a cutter to cut and hold a sample from the item as it passes there through, the punch having a bore aligned to the elongate direction,
  • a plunger slideably supported at said bore to be able to move between a retracted position and an advanced position relative said punch, the movement from the retracted position to the advanced position causing, in use, the cutter held sample to be displaced from the cutter,
  • the sample collector driver comprising
  • a body interfaced with said sample collector in a telescopic manner wherein in a telescopically compact position the driver can drive the sample collector through the item whilst keeping the plunger in the retracted position so that a sample can be cut and held by the cutter and in a telescopically expanded position the driver is able to be driven in the same direction as when driving the collector through the item and cause the plunger to move from its retracted position to its advanced position.
  • the body and the punch are in contact with each other so that the body, when being driven, pushes onto the punch to drive the sample collector through the item.
  • the body and the punch are in contact with each other so that the body, when being driven, pushes onto the punch and not onto the plunger, to drive the sample collector through the item.
  • the body and the punch are in contact with each other so that the body, when being driven, pushes onto the punch and does not cause the plunger to move to its advanced position, to drive the sample collector through the item.
  • the body and the plunger are in contact with each other so that the body, when being driven in the same direction, pushes onto the plunger to move the plunger to its advanced position.
  • the body and the plunger are in contact with each other so that the body, when being driven in the same direction, pushes onto the plunger and not onto the punch, to move the plunger to its advanced position.
  • the body and the plunger are in contact with each other so that the body, when being driven in the same direction, pushes onto the plunger and does not cause the punch to move, to move the plunger to its advanced position.
  • one of the body and the plunger carries a dog that in said compact position is help in an inactive mode preventing the driving of the plunger by the body to its advanced position and in the expanded position couples said plunger and body.
  • the dog is a resiliently flexible member of one of said body and plunger, held under bias when in its inactive mode by the other of said plunger and body when the sample collector and the body are in the compact position.
  • the dog is a resiliently flexible member of one of said body and plunger, biased towards a position that, when the sample collector and the body are in the expanded position, presents itself for engagement with a driving surface of the other of said plunger and body so that when said body is moved in the same direction, the plunger is driven towards its advanced position.
  • the dog is carried by said plunger and is able to align to index with a said driving surface of said body when the body is in the expanded position relative said sample collectors.
  • the sample collector is generally of circular cross section and elongate and straight, the cutter located at one end of the collector.
  • the punch is generally of circular cross section and elongate and straight, the cutter located at one end of the collector.
  • the punch is generally of circular cross section and elongate and straight, the cutter located at one end of the collector.
  • the plunger protrudes from the end of the punch opposite the cutter.
  • the plunger includes an umbrella acting as said dog, the umbrella resiliently moveable between a contracted condition and an expanded condition wherein the umbrella is (a) held in one of said contracted and expanded conditions by a lateral surface or surfaces of said body along which said umbrella can slide when the body moves to the expanded position relative the sample collector and (b) can move to the other of the expanded or contracted conditions when the body has moved to the expanded position so that the umbrella can engage said body to allow the body to move the plunger to the advanced position.
  • the umbrella acting as said dog, the umbrella resiliently moveable between a contracted condition and an expanded condition wherein the umbrella is (a) held in one of said contracted and expanded conditions by a lateral surface or surfaces of said body along which said umbrella can slide when the body moves to the expanded position relative the sample collector and (b) can move to the other of the expanded or contracted conditions when the body has moved to the expanded position so that the umbrella can engage said body to allow the body to move the plunger to the advanced position.
  • the plunger is rod shaped.
  • umbrella is located at an end of the plunger distal from most the cutter.
  • the body is elongate and straight.
  • the body is elongate and straight and of the same exterior cross section as the punch.
  • the body and the punch form a continuous elongate drivable member when in the compact position.
  • the body includes a receptacle region to receive a driver, directly or indirectly, of a sampler device that can apply a force to cause the sample collector to be driven through the item.
  • the receptacle region is adapted and configured so that it can be engaged by said driver, directly or indirectly, to cause the body to be displaced in a driving direction and in a direction opposite the driving direction.
  • the body is to seal the entrance of a sample storage container with which the string is to engage after the sample has been taken.
  • the present invention may broadly be said to be, as a set a string as herein described and a sample storage container defining a mouth opening leading to a storage region of the storage container, the mouth opening able to receive the string after the cutter has been driven through the item and is carrying a sample.
  • the storage container is adapted and configured to retain the sample collector (preferably the punch) once received at said mouth opening in a manner to allow the driver to be moved relative said sample collector and said storage container in a direction to move it to the expanded position relative the sample collector.
  • the sample collector preferably the punch
  • said body advances back towards punch as it drives said plunger to its advanced position, the so advancing body causing a sealing of said mouth opening.
  • said mouth opening and said body include a region of mutually cooperative surface or surfaces that allow the body to seal the mouth opening and hence the containment region of the storage container.
  • Preferably container comprises a container body and a cap removably engaged to the container body, the mouth opening is a passage defined by said cap.
  • said passage and said body of the driver are adapted and configured to engage in a snap-fit manner to retain the body of the driver with the cap and seal the containment region.
  • the present invention may broadly be said to be a method of taking and storing a sample from an item using the set as herein described, by placing the storage container and string on opposed sides of a gap, held by a sampler device in axial alignment, the sampler device including an actuator to act, directly or indirectly on said sample collector driver,
  • the plunger is in its retracted position relative said punch and said sample collector driver is in the compact position relative said punch.
  • the plunger is in its retracted position relative said punch and said sample collector driver is in the expanded position relative said punch.
  • the plunger is in its advanced position relative said punch and said sample collector driver is in or more proximate its compact position relative said punch than its said expanded position.
  • the sample collector driver is driven into the mouth opening in a manner to seal the mouth opening.
  • the present invention may broadly be said to be a sampling assembly to be driven in one direction relative to and to collect and dispense a biological sample from an item and into a storage container, said assembly comprising :
  • a sample collector comprising:
  • a punch presenting at one end a cutter to cut and hold a sample from the item as it passes there through or over,
  • a plunger slideably supported by said punch to be able to move between a retracted position and an advanced position relative said punch, movement from the retracted position to the advanced position causing, in use, the cutter held sample to be displaced from the cutter,
  • a sample collector driver comprising :
  • a body telescopically interfaced with said sample collector to, in a first position relative said punch and plunger, be able to drive said punch and plunger in said one direction, and in a second position relative said punch and plunger, having moved in a direction opposite said one direction, having ratcheted to engage with said plunger in a manner to be able to cause said plunger to move relative to said punch when said sample collectors driver is again driven in said one direction.
  • the present invention may broadly be said to be a sampling string to collect a biological sample from an item, said string comprising : a sample collector comprising :
  • a punch presenting at one end a cutter to cut and hold a sample from the item as it passes there through or over,
  • a plunger slideably supported by said punch to be able to move between a retracted position and an advanced position relative said punch, movement from the retracted position to the advanced position causing, in use, the cutter held sample to be displaced from the cutter,
  • a sample collector driver that in a first condition is engaged said punch to, in use, be able to drive said punch over or through said item when in a first position relative punch and is able to telescopically slide relative said plunger to a second condition that is away from and/or not engaged to said punch to ratchet with said plunger and engage therewith to be able to drive the plunger from its retracted position to its advanced position.
  • the driver is prevented from driving the plunger to its advanced position.
  • the plunger is not in driving contact with said driver and in said second condition the punch is not in driving contact with said driver.
  • the plunger is not in driving contact with said driver and in said second condition the punch is not in driving contact with said driver.
  • said string is an elongate straight string and when said driver is in said second condition said string is longer than when in said first condition.
  • said driver includes a recess into which the plunger of the sample collector extends at least when in the first condition.
  • said plunger projects from said bore and into driver.
  • the present invention may broadly be said to be a sample collector to be driven by a driver to remove and hold a sample from the item that it can be driven over/through comprising :
  • a punch presenting a cutter and presenting a driver engageable region to allow the driver to drive said punch to remove said sample from said item
  • the present invention may broadly be said to be a sampling string to collect a biological sample from an item, said string comprising : a sample collector comprising :
  • a punch presenting at one end a cutter to cut and hold a sample from the item as it passes there through or over,
  • a plunger slideably supported by said punch to be able to move between a retracted position and an advanced position relative said punch
  • a sample collector driver that in a first condition is engaged said punch to, in use, be able to drive said punch over or through said item
  • the present invention may be broadly be said to be a cartridge comprising a body that include a storage container holding region at where a storage container as herein described is located and a sample collector holding region at where a sample collector as herein described is located, preferably with the sample collector driver engaged with said sample collector in said condition where said plunger is in its retracted position and unable to be moved by said sample collectors driver to its advanced position, there the body holds the sample collector and storage container in alignment with each other for sample taking and spaced apart with a sufficient gap to allow part of an item to be sampled to locate at said gap.
  • the cartridge is adapted and configured to be loadable and unloadable to/from a sampler device that includes and actuator to cause sampling to take occur.
  • the body of the cartridge is adapted and configured to shield the sampler device at the gap from said item placed in the gap, and any exudates expressed or expelled from said item during sampling.
  • one (or more) of the invention(s) herein described may be used for production animals and for companion animals.
  • one (or more) of the invention(s) herein described may only be used for production animals.
  • one (or more) of the invention(s) herein described may only be used for companion animals.
  • Preferably production animals include but are not limited to bovine, pigs, deer and sheep.
  • companion animals include but are not limited to horses, cats and dogs.
  • This invention may also be said broadly to consist in the parts, elements and features referred to or indicated in the specification of the application, individually or collectively, and any or all combinations of any two or more of said parts, elements or features, and where specific integers are mentioned herein which have known equivalents in the art to which this invention relates, such known equivalents are deemed to be incorporated herein as if individually set forth.
  • Figure 1 shows an exploded view of a storage container axially aligned with a sample collector and sample collector driver plus an associated push rod
  • Figure 2 is an exploded view of the string of components comprising of the sample collector comprising of the punch and plunger and the sample collector driver and push rod,
  • Figure 3a is a cross sectional view through the components of Figure 2 showing the plunger with its umbrella in an expanded, drivable condition
  • Figure 3b shows the umbrella of the plunger in a contracted condition
  • Figure 4 is a perspective view of the storage container and sample
  • collector/sample collector driver/push rod string intermediate of which part of an ear of an animal is placed prior to sampling
  • Figure 5 is a cross sectional view of the components of Figure 4 with the cutter of the sample collector having punctured the ear of the animal,
  • Figure 6 is a cross sectional view of the components of Figure 4 wherein the sample that has been collected from the ear of the animal is driven into the storage container,
  • Figure 7 shows the components of Figure 4 and wherein the punch is about to rupture the frangible seal of the cap of the storage container
  • Figure 8 is a view of the components of Figure 4 wherein the frangible seal has been ruptured to allow for the sampler to enter the storage region of the storage container
  • Figure 9 shows the step in the process of the components of Figure 4 wherein the sample collector driver has retreated back towards its pre-delivery position in order to cause a telescopic movement relative to the plunger and allow for the two components to ratchet to a second condition so that the plunger is then able to be actuated to move to an advanced position by the sample collector,
  • Figure 10 is a cross sectional view of the sample collector driver and the plunger, the plunger and its umbrella shown in a contracted condition
  • FIG 11a is a view of Figure 10 but wherein the umbrella of the plunger is shown in unexpanded condition
  • Figures l lb-j show variations of the telescopic ratchet relationship that can be established between the sample collector driver and the plunger in order to allow for the plunger and the sample collector driver to move between a retracted and advanced position and where a ratcheting relationship is provided by varying features of the sample collector driver and the punch,
  • Figure 12 shows the sample collector driver and plunger in a telescopically expanded relationship, the plunger still being in a retracted condition relative to the punch but in a position able to be driven by the sample collector driver to an advanced position,
  • Figure 13 illustrates the sample collector driver and plunger indicating that contact may exist between the interior wall of the sample collector driver and the driving end of the plunger
  • Figure 14 shows the sample collector driver and plunger wherein the plungers umbrella is in an expanded condition able to then be driven by a different surface of the sample collector driver
  • Figure 15 illustrates the sample collector driver having been advanced, after the momentary retraction, back towards the storage containment region in order to then drive the plunger relative to the punch to cause the sample to drop into the storage containment region and wherein the sample collector driver has engaged at the passage of the cap of the storage container in order to seal the storage container,
  • Figure 16 shows the push rod having been retracted from the sample collector driver and the sampling and storage process being complete
  • Figure 17 is an enlarged view of the string of components including the sample collector, the sample collector driver and the push rod wherein these components are in a condition for punching through the ear of an animal
  • Figure 18 shows the components of Figure 17 but wherein the sample collector driver has telescopically moved relative to the sample collector and to its expanded position relative thereto in order to ratchet with the plunger for the purposes of then re-advancing for the purposes of driving a plunger relative to the punch as can be seen in Figure 19,
  • Figure 19 shows the plunger having been moved to its advanced position relative to the punch by a re advancement of the sample collector driver
  • Figure 20 shows an assembly of the storage container and the string of components including the sample collector and sample collector driver associated with a cartridge, the cartridge being able to be delivered to an end user with the sample collector related string and storage container in pre alignment with the gap between at where the ear of an animal may be placed,
  • Figure 21 is a cross sectional perspective view of Figure 20
  • Figure 22 shows a partially expanded view of the components of Figure 20
  • Figure 23 shows a cross sectional view of the components of Figure 20
  • Figure 24 shows a cross sectional view of the components of Figure 20 but wherein the string of components including the sample collector is advanced towards the storage container immediately prior to the taking of a sample from the ear of an animal,
  • Figure 25 shows the storage container having received the sample and the sample collector having sealed the storage container
  • Figure 26 shows a perspective view of a sampler device with the cartridge of Figure 20 loaded therewith
  • Figure 27 is another perspective view of Figure 26
  • Figure 28 is a side view of a sample collector device and the cartridge in an expanded condition
  • Figure 29 is a perspective view of Figure 28
  • Figure 30 is a cross sectional view of the sampler device and the cartridge loaded therewith including showing part of the mechanism for the purposes of driving the string of components including the sample collector through the ear of an animal and wherein the mechanism as shown in a condition open prior to the taking of a sample,
  • Figure 31 shows the mechanism of Figure 30 and wherein the sample collector string has been advanced towards the storage container, the sample collector having entered the storage container and the frangible membrane having been ruptured but prior to the mechanism of the sampler device having been actuated to cause the plunger to move to its advanced position
  • Figure 32 is a view of the mechanism of the sampler device and wherein the mechanism is in a condition to advance the plunger relative to the punch for the purposes of dispensing the sample into the sample containment region
  • Figure 33 is a view of the mechanism of the sampler device wherein the actuator of the sampler has driven the sample collector driver to its final position to seal the storage container and to move the plunger to its advanced position to dispense the sample into the storage containment region.
  • Figure 34 shows a view of the mechanism of Figure 30 with further components according to one embodiment for an operation of the drive rod.
  • Bio samples may be taken by the sample collectors herein described from an organism such as a plant or an animal particularly including pigs, goats, cattle, sheep, poultry and fish.
  • the sample is a tissue sample that is taken from the ear of an animal.
  • a sample collector 601 and storage container 602 is shown.
  • the collector is able to be driven by a tool such as the tool shown in the drawings to engage (and preferably become secured) with the container that is also held by the tool in a predetermined position aligning the two together.
  • a sample storage container 602 includes a container body 615 that has a containment region 616 that is terminated by an end wall 618 and a side wall 617 and includes a cap 619.
  • the end wall 618 of the containment region 616 is closed and not openable. It may alternatively be openable. In the preferred form the side and end walls are integrally formed.
  • the container body 615 is preferably made from a plastics material. It may be a moulded plastics material. A preservative may be provided inside of the containment region 616.
  • the storage container 602 can receive a sample collector retained sample. Prior to receiving a sample the containment region 616 is preferably sealed. In the preferred form the storage container 602 also includes an end at where the sample collector penetrates the storage container, preferably in the form of a cap 619 that is either integrally formed with or secured and preferably removably secured to the container body 615. The cap 619 receives the sample collector 601 upon the taking of a sample such as from an animal's ear.
  • the cap 619 is preferably threadingly engaged to the container body 615 by virtue of threads 620.
  • the cap can be screwed onto and preferably partially ascend into the container body 615. It can be unscrewed from the container body to gain access to the containment region. This may occur in a laboratory to gain access to the sample in the containment region.
  • the cap has a passage 621 that has an entrance 622 and an end 623 opposed at the entrance 22.
  • the passage 621 is of a shape and configuration to be able to snugly receive the sample collector 601. It is preferably cylindrical in shape.
  • the side walls of the passage 621 correspond substantially to an exterior side wall of the punch 604. Such an exterior side wall is preferably round in cross sectional shape.
  • no gap or passage exists between the cap and the sample collector when the sample collector is located in the passage. This helps seal the storage region 616.
  • the passage is sealed by a frangible seal 624.
  • the frangible seal 624 when the cap 619 is secured to the container body 615 and prior to the sample collector being received, seals the containment region 616 of the container body.
  • the frangible seal 624 is preferably frangeably attached so that when a sample collector is delivered into the passage 621 it is able to push against the seal 624 to at least partially separate the seal 624 and allow for the sample to be pushed into the storage region 16. In the preferred form the sample is still retained in the bore 608 at the cutting end of the punch 604 when the frangible seal is at least partially separated to open the storage region 616.
  • the cap preferably has an additional function and/or feature to help seal the containment region, that will herein be described.
  • the sample storage container 602 is able to receive the sample collector 601 also shown in Figure 1.
  • the sample collector 601 includes at a cutting end 606, a cutter 605 associated with or part of a punch 604.
  • the sample collector 601 shown in Figure 4 is in a pre-sampling condition relative to the organism 603 to be sampled and the storage container 2, aligned with the storage container 602 intermediate of which for example a part of an animal's ear 603 is positioned.
  • the sample collector 601 comprises a punch 604 having a body with a cutter 605 presenting a cutting end 606 that is able to penetrate into the organism to be sampled.
  • the cutter 605 is provided at a first end of the punch 604.
  • the punch has an opposing driving end 607. It is at the driving end that the punch can for example be driven by a driver that will hereinafter be described for the purposes of pushing the cutting end (and preferably the entire collector) at least partially into and preferably all the way through the organism to be sampled to take a sample. In the preferred form the entire sample collector 601 is pushed through the tissue to be sampled.
  • the body of the punch 604 preferably has a bore 608.
  • the bore 608 extends from one end of the punch 604 to the other. It preferably extends along the length of the punch 604 between the cutting end 606 and the driving end 607.
  • the punch 604 is an elongate straight body and the bore is centrally located within the punch.
  • the cutter 605 defines at least part of this bore.
  • the bore is preferably circular in cross section.
  • the cutter 605 preferably has a circular cutting end.
  • the cutter is substantially cylindrical shaped. It will be appreciated that alternative shapes can be used. It may be 3 or more sided for example.
  • the cutter 605 is provided at the cutting end of the punch to facilitate removal of a sample from an organism.
  • the cutter may be attached to the punch or it may be integral with the punch so that the cutter and the punch are formed as a single part. It need not be formed to take a core sample by pushing through the organism but a sample instead taken at an edge of surface of the organism. However, being of a hollow section such as a cylindrical section offers the added benefit of the cutter being able to retain the sample as a plug.
  • the cutter 605 preferably extends from and surrounds one end of the bore 608 of the punch at the cutting end of the punch.
  • the bore 608 is effectively a blind bore by virtue of the provision of a plunger 609 being located in the bore of the punch 604.
  • the plunger 609 is aligned with the bore.
  • the plunger 609 is held at the bore 608 of the punch to form part of the sample collector 601.
  • the plunger protrudes at least partially from the bore as seen in Figure 4.
  • the plunger and the punch in a pre-sampling condition are configured so that a cavity, extending inwards from the cutting end 608 and that is part of the bore, is provided for a sample to be collected in as the sample collector 601 is driven into and/or through the organism.
  • the plunger has a first end 687 and a second end 666.
  • the first end is a pushing end to push onto the sample to push it out of the cavity.
  • the second end is the driving end to drive the plunger in a manner that will herein after be described.
  • the fit of the plunger 609 in the bore 608 is snug yet allowing for the plunger to be slid relative to the punch.
  • the plunger's outer surface is contiguous the inner surface of the bore. This ensures that a close fitting configuration is provided between the punch 604 and the plunger 609 thereby helping to prevent the ingress of contaminants from the driving end of the punch to or towards the cutting end of the punch through the bore.
  • the plunger and the punch are in a slidable relationship with each other.
  • the plunger 609 are in a slidable relationship with each other so that a sample, once collected from the organism and retained in the bore at and near the cutting end 606 can be ejected therefrom by the plunger 609.
  • the first end is able to be pushed all the way to the cutting end 606 to thereby eject the sample collected from the sample collector.
  • Actuation of the plunger may be by pushing at the first end 10 of the plunger.
  • the plunger is able to be positioned in an active position as shown in Figure 17 and be moved to a plunged position as shown in Figure 19 in a manner herein after described.
  • the plunger 609 includes an enlarged region 613 that prevents the plunger from being pulled out of the punch 604 from the driving end 607.
  • the enlargement and a corresponding constriction in the bore of the punch limit the movement of the plunger and it cannot be removed by pulling the plunger out of the punch from the driving end 607. This helps prevent external access being gained to the sample once collected and it held at the cavity or dispensed further into the containment region 616 of the storage container.
  • the actuation of the plunger causes the sample to eject from the bore and into the containment region 616.
  • the plunger 609 preferably includes an EID tag 614.
  • the plunger as has hereinbefore been described, can move axially along the bore of the punch to allow for the sample that is collected by the cutter 605 to be pushed from the collector and into the containment region 616 of the storage container 602.
  • the plunger includes a pushing end 687 that is able to push the sample from the cutter and it includes a driving end 666.
  • the sample collector 601 is preferably able to be pushed to be displaced by a sampler device through for example the ear of an animal in order to cause the sample to be collected.
  • the sample collector 601 is associated with a sample collector driver 626 during the process of sampling.
  • the sample collector and sample collector driver may be assembled as an elongate string.
  • the sample collector driver first pushes the sample collector through the ear of an animal. It can then be caused to push the plunger to dispense the sample into a containment region and then optionally to seal the containment region. This will now be described.
  • the sample collector driver 626 is provided for sampling, connected to the sampler collector, as is for example seen in Figure 4 and 5.
  • the form of the connected sample collector driver and sample collector is such that the components are axially aligned and resemble an elongate (preferably straight) string akin to a drill string, along the aligned axis.
  • a push rod 662 is removably connected to the sample collector driver 626 during the process of sampling.
  • the push rod 662 is optionally provided for the purposes of driving the sample collector and the sample collector driver through the ear of an animal and provides an extension or a sleeve about the driving rod of the sampler device 1300. This helps to avoid cross contamination of samples during the sampling process.
  • the push rod 662 once sampling has occurred, is able to be removed from the sample collector driver 626.
  • an interference fit plug 667 is provided.
  • the interference fit plug 667 is able to locate in a socket 668 at an end of the sample collector driver 626 but is able to be removed therefrom upon the application of a sufficient force.
  • the assembly of the sample collector 601 and the sample collector driver 626 and optionally where included the push rod 662 are substantially of a slender elongate configuration that is substantially of a constant diameter or other external profile. This helps ensures that the assembly is able to be pushed through the ear of an animal to collect a sample.
  • the sample collector and sample collector driver and push rod are preferably elongate and straight and serially connected as in a drill string. They are preferably axially aligned.
  • the push rod 662 as seen in Figure 3a is preferably of a configuration to act as a sleeve for the actuator driver of the sampler device.
  • a cavity 669 is provided into which the actuator driver can locate to then drive the assembly of the sample collector, the sample collector driver and the push rod by pushing on the end wall 670 of the push rod 662.
  • the plunger 609 has a telescoping relationship with the sample collector driver 626 such that the plunger and the sample collector driver may move between a first and second position relative to each other.
  • the plunger and sample collector driver may be engaged in a ratchet-like connection.
  • the ratchet-like connection acts to allow movement in one telescoping direction but then to prevent motion or to prevent motion past a certain point in the opposite direction.
  • the ratchet-like connection may be in the form of a dog or umbrella like formation 665 or other physical obstruction or engagement provided by either the plunger or sample collector driver or by provided an interaction of both the plunger and sample collector driver.
  • the plunger may include a driving end 666 that is defined by an umbrella 665.
  • the umbrella is naturally biased to an expanded condition as shown in Figure 14 but can be caused/forced to assume a contracted condition as seen in Figure 13.
  • sample collector driver 626 The relationship between the sample collector driver 626 and the punch 604 and the plunger 609 is such that the three components are able to axially displace relative to each other. This will now be described.
  • the sample collector and sample collector driver and storage container are able, for the purposes of sampling, to be held by a sampler device 1300.
  • a first condition (the punching condition) as seen in Figure 5 the sample collector driver 626 is engaged with the punch 604 at an interface 671 so that a force applied by the actuator mechanism of the sample device 1300 via the push rod 662 pushing onto the sample collector driver 626 can push the punch 604.
  • the punch 604 and the sample collector driver 626 are in a compact position relative each other for the purposes of such pushing to drive the sample collector and the sample collector driver through the ear of an animal.
  • the punch and plunger are in a retracted position relative each other so that a cavity is defined by the cutter and the plunger to allow a sample to be collected and held in the cavity.
  • the plunger and the sample collector driver are in a first position where the plunger is located in the cavity 672 of the sample collector driver.
  • the umbrella of the plunger is in a contracted condition. So in the first condition the:
  • Plunger and sample collector driver are in a first position with the umbrella in the contracted condition.
  • the sample collector and preferably also the sample collector driver are, in this first condition, able to be driven through the ear of the animal and engaged with the storage container as seen in Figure 6.
  • the plunger 609 In a second condition, after the cutter has passed through the ear of the animal and a sample is held in the cavity, as seen in Figure 9, the plunger 609 remains in a retracted position relative to the punch 604.
  • the punch is snugly held by the cap of the storage container and sample collector driver is moved back towards where it came from by the mechanism of the sampler device.
  • the sample collector driver and punch in the second condition are in an expanded position relative each other. They are preferably telescopically engaged.
  • the punch and plunger remain in a retracted position but the plunger and sample collector driver are in a second position relative each other where the umbrella is in an expanded condition and no longer in the cavity 672.
  • Plunger and sample collector driver are in a second position with the umbrella in the expanded condition.
  • a third condition as seen in Figure 15 the sample collector driver is pushed back towards the punch and preferably back to or near its earlier compact position. This is achieved by the driving mechanism of the sampler device that will herein after be described.
  • the plunger has moved to an advanced position relative the punch.
  • the sample collector driver and plunger remain in the second position with the umbrella in the expanded condition.
  • the sample collector driver is also now fully seated with the storage container at the cap where it may seal the storage container.
  • Plunger and sample collector driver are in a second position with the umbrella in the expanded condition.
  • the opposite distal end of the plunger includes an umbrella 665 that is in a contracted condition when the punch and the sample collector driver are in the compact position.
  • the umbrella is retained in a contracted condition by virtue of being in a first cavity 672 of the sample collector driver 626.
  • the first cavity 672 is of a nature that will hold the umbrella 665 of the plunger 609 in a contracted condition as seen in Figure 3b.
  • the driving end 666 of the plunger is located against the end wall 673 of the first cavity 672.
  • the plunger 609 extends from the first cavity through a second cavity 674 from the sample collector driver 626.
  • the first cavity 672 is a bore of a first diameter.
  • the second cavity 674 is preferably a bore of a larger diameter and includes an end wall 675 with which the driving end 666 of the plunger can engage when the plunger has been axially displaced relative the sample collector driver 626 and out of the first cavity 672.
  • the umbrella 665 which is naturally biased to an expanded condition, is able to expand and upon such expansion is then not able to re-enter the first cavity 672. Instead the driving end 666 is able to contact the end wall 675 of the second cavity 674.
  • the plunger being displaced relative the punch. This occurs by virtue of the interaction of the driving end 666 with the end wall 675 of the second cavity.
  • the umbrella 665 is preferably integrally formed as part of the plunger 609.
  • the plunger and its umbrella is preferably of a plastics material and the umbrella is preferably naturally formed in an expanded condition but is of a configuration that allows for it to be collapsed to a contracted condition as seen in Figure 3b.
  • the storage container 602 and preferably its cap 619 is able to snugly receive the punch 604 and be guided for a sliding movement into the bore of the cap 619.
  • the assembly of the sample collector and sample collector driver is able to be driven through the ear of the animal as seen in Figure 7. As previously described, the axial relationship between the punch and the sample collector driver and the plunger remains the same at this stage of sampling as before the sample was taken.
  • the assembly of the sample collector driver and the sample collector is merely displaced through the ear of the animal and has engaged with the cap of the storage container 2.
  • the sample collector is able to advance in the bore of the cap in order to reach the flangible seal. This seal is preferably of a configuration as hereinbefore described.
  • the punch can push onto, to remove the flangible seal 624.
  • the axial relationship between the sample collector driver 626 and the sample collector 601 is changed.
  • the sample collector driver 626 is retracted at least partially back towards where it came from and moves at least partially back out of the cap as seen in Figure 9.
  • the mechanism of the sampling device may cause this displacement.
  • the sample collector 601 (the punch 604 and plunger 609) remain in its position relative to the storage container where it was delivered by the sampler device and does not retract back with the sample collector driver 626.
  • the partial retraction of the sample collector driver 626 causes a relative axial displacement of a distance sufficient to allow for the driving end 666 of the plunger 609 to displace out of the first cavity 672 of the sample collector driver 626.
  • the umbrella to expand.
  • the retraction distance is substantially no greater than that required for the driving end 666 to move out of the first cavity 672 and allow for the umbrella to expand.
  • the umbrella in its expanded condition is now able to engage the end wall 675 of the second cavity 674 of the sample collector driver 626.
  • the size or shape di of the driving end 666 of the plunger is approximately the same as the size 02 of the cavity 672 of the sample collector driver. This is when the punch is in its compact position relative to the sample collector driver and the plunger is the first position relative to the sample collector driver. In the second position of the plunger relative to the sample collector driver, the size or shape Di of the driving end corresponds to the size or shape D2 of the second cavity of the sample collector driver.
  • sample collector driver 626 Further displacement of the sample collector driver 626 into the cap causes the sample collector driver 626 to drive the plunger 609 and thereby will eject the sample 612 from the cutter 605 as seen in Figure 12.
  • sample collector driver 626 may include an enlargement 676 that is able to push into an annular recess 677 of the bore of the cap. The interaction of the enlargement and the annular recess can provide further barrier to the ingress or egress of contaminants and/or sample material to and from the storage region 616 of the storage container 602.
  • the sample collector driver 626 and punch 604 are in a compact relationship relative to each other and the plunger 609 is in a retracted position relative to the punch 604.
  • the punch and sample collector driver are in their expanded position relative to each other, where the sample collector driver 626 has been retracted away from the punch 604 to allow for the umbrella 665 to expand and for the driving end 666 to contact the end wall 675 of the sample collector driver.
  • An advancement of the sample collector driver 626 back towards the punch 604 will then cause the plunger 609 to displace relative to the punch 604 to its advanced position and for the sample to be ejected.
  • the displacement back towards the punch 604 will also displace the sample collector driver 626 further into the cap than it was when it was in a punch condition as seen in Figure 17 so that the sample collector driver 626 can fully seal the bore of the cap.
  • sample collector driver may be removed from the sample collector after it has driven the sample collector into the storage container and has actuated the plunger.
  • the sample collector driver may not seal the storage container.
  • the sample collector driver maybe disposed.
  • Figures l lb-j show variations to the telescopic ratchet relationship of the plunger and the sample collector driver.
  • Figures 11 c, e, g and I shows the driver and plunger in where the relationship between the two, when assembled would be where the plunger is in the retracted position and figures d,f,h,j respectively shows the driver and plunger in where the relationship between the two, when assembled would be where the plunger is in the advanced position.
  • the sample collector and sample collector driver and the storage container may be provided in a form associated with a cartridge 1303.
  • the cartridge may be a body that defines a storage container holding region 1306 and a sample collector and sample collector driver holding region 1307 as seen in Figure 20 and 21. An exploded view of this is shown in Figure 22.
  • the body of the cartridge 1303 holds the sample collector and storage container and sample collector driver in an axially aligned condition. It holds the storage container in a condition separated by a ga p 1308 from the sample collector.
  • the gap 1308 is sufficiently large to allow for an ear 630 of an animal to be inserted into the gap and be presented to be axially aligned for the purposes of taking the sample.
  • the cartridge 1303 is able to be loaded into a sampler device 1300 as shown in Figure 26-30. It is preferably able to be removably loaded so that once the sample has been taken, the cartridge can be removed. Upon removal the storage container may remain associated with the cartridge and be shipped as a unit to a laboratory for further processing.
  • FIG 23 A cross-sectional view of the arrangement of Figure 21 is shown in Figure 23. This is the pre-sampling condition where the sample collector driver and sample collector 601 are on one side of the gap 1308 and the storage container 602 is on the opposite side of the gap.
  • Figure 24 shows the sample collector 601 and sample collector driver 626 assembly being delivered for taking a sample of the ear 603 of an animal.
  • Figure 25 shows the sample collector and sample collector driver having been delivered to the sample collector, the sample collector driver 626 sealing the cap of the sample collector and the plunger having been actuated to push the sample 612 into the storage region 616.
  • a sampler device 1300 that includes a body 1301 and a handle 1310.
  • a handle is able to be actuated by a user to cause a shaft 1360 of the sampler device to actuate the sample collector and sample collector driver assembly, preferably via the push rod 662, to collect the sample and deliver it to the storage container.
  • the cartridge 1303 is able to be removably associated with the sampler device 1300. In a removed condition shown in Figure 28 the cartridge 1303 with the sample collector, sample collector driver and storage container pre-associated therewith, (preferably at the factory and prior to delivery of the end point of use), is able to be inserted into the sampler device 1300.
  • the cartridge 1303 is able to lodge and thereat be releasably held.
  • the cartridge may include an area where a person is able to write information onto.
  • a pen may be used for this purpose.
  • the information may for example be a date and/or an animal number as may be found on an eartag of an animal .
  • the cartridge may carry an EID. This may carry information that is matched to the EID information of the sample collector and/or the container.
  • the mechanism includes a drive shaft 1360 that is able to be actuated for driving towards the gap 1308, aligned with each of the sample collector storage container, sample collector driver and the push rod when used. All these elements are in alignment and in alignment to the direction of displacement of the drive shaft.
  • the drive shaft is able to move in the direction to deliver the sample collector and sample collector driver across the gap, through the ear of an animal and into the storage container.
  • the trigger mechanism that is used for the sampler device may be one that causes the movement of the drive shaft in a direction to drive the collector towards the storage container and may manually cause the shaft to be partially retracted in order to partially withdraw the plunger from the sample collector driver so that the umbrella is able to move from its contracted condition to its expanded condition.
  • the drive shaft may then be manually caused to drive back in the driving direction to finalise the movement of the plunger and sample collector driver to the third condition.
  • This may be caused by moving the handle of the sampler device appropriately both in one direction and in an opposite direction.
  • this may be caused by the operation of an intermittent drive mechanism capable of causing the driving, partial retraction, then return to driving under a single driving input.
  • the driving input may be the movement of the handle of the sampler, or could be the operation of a motor such as an electric motor.
  • the trigger mechanism may be such that the drive shaft is able to be driven in this manner by the action of an adequately controlled motor, such as an electric motor or even more particularly a DC servo motor.
  • An electric motor may be used with or without an intervening intermittent mechanism to drive the drive shaft 1360. Such a configuration is shown in Figure 34, where a servo motor 1370 drives the drive shaft 1360.
  • the linkage between the servo motor 1371 and drive shaft 1360 may comprise a mechanism wherein the driving rod is allowed to retract, such as under a bias, a certain amount once it has reached a certain point of its extension. The mechanism may then re-engage the linkage to the servo motor 1370, allowing the drive rod 1360 to be driven forwards again.
  • the linkage between the servo motor 1370 and driving rod 1360 in Figure 34 may comprised a fixed linkage, without an intermittent mechanism, wherein the extension, retraction and return to extension of the drive rod 1360 are provided by the driving of the servo motor 1370.
  • the control over the timing, speeds and duration of the operation of the drive rod 1360 in each direction may be provided by control of the servo motor 1370. It is contemplated that the use of commonly available control systems and electric motors may in combination be suitable to provide the nature of control, including both speed, direction and location, as desirable to perform the previously described function of the drive rod .
  • the servo motor 1370 may be powered by an internal power source such as a battery 1371.
  • the operation of the servo motor 1370 may be initialised by an actuation of the handle 1302 resulting in the engagement of a switch 1372.
  • the drive rod 1360 may be coupled to a linear motor, wherein the linear motor is capable of being controlled and operated to drive the drive rod 1360 in both direction as previously described. In such a configuration no drive linkage between the motor and drive rod may be required.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne, comme une chaîne allongée assemblée, un collecteur d'échantillon et un pilote de collecteur d'échantillon pour entraîner au moins le collecteur d'échantillon à travers un objet à échantillonner. Le collecteur d'échantillon comprend un poinçon ayant un alésage aligné avec la direction allongée. Une extrémité du poinçon et de l'alésage présente un dispositif de coupe pour couper et retenir un échantillon à partir de l'objet au niveau de l'alésage lorsque le poinçon passe à travers l'échantillon. Le collecteur d'échantillon comprend en outre un piston supporté de manière coulissante sur ledit poinçon pour pouvoir se déplacer dans ledit alésage entre une position rétractée et une position avancée par rapport audit poinçon. Le déplacement du piston de la position rétractée à la position avancée amène, lors de l'utilisation, l'échantillon maintenu par le dispositif de coupe à être déplacé à partir du dispositif de coupe. Le pilote de collecteur d'échantillon comprend un corps interfacé avec ledit collecteur d'échantillon d'une manière télescopique.
PCT/IB2017/051119 2016-03-08 2017-02-27 Échantillonneur biologique, collecteur et récipient de stockage WO2017153865A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP17762607.4A EP3426162A4 (fr) 2016-03-08 2017-02-27 Échantillonneur biologique, collecteur et récipient de stockage
CA3031581A CA3031581A1 (fr) 2016-03-08 2017-02-27 Echantillonneur biologique, collecteur et recipient de stockage
MX2018010844A MX2018010844A (es) 2016-03-08 2017-02-27 Muestreador biologico, recolector y contenedor de almacenamiento.
KR1020187028915A KR20180131564A (ko) 2016-03-08 2017-02-27 생물학 샘플러, 수집기 및 보관 용기
US16/083,306 US20190094112A1 (en) 2016-03-08 2017-02-27 Biological sampler, collector and storage container
JP2018547350A JP2019507881A (ja) 2016-03-08 2017-02-27 生物学的サンプラー、収集器、及び格納コンテナー
RU2018135230A RU2018135230A (ru) 2016-03-08 2017-02-27 Устройство отбора, устройство сбора и контейнер хранения биологического образца
AU2017230983A AU2017230983A1 (en) 2016-03-08 2017-02-27 Biological sampler, collector and storage container
CN201780027569.9A CN109414256A (zh) 2016-03-08 2017-02-27 生物取样器、收集器和存储容器
BR112018068083A BR112018068083A2 (pt) 2016-03-08 2017-02-27 série, grupo, método, conjunto de amostragem, coletor de amostra, e, cartucho

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201662305498P 2016-03-08 2016-03-08
US62/305,498 2016-03-08
US201662316499P 2016-03-31 2016-03-31
US62/316,499 2016-03-31
NZ71858716 2016-03-31
NZ718587 2016-03-31
NZ725837 2016-11-02
NZ725835 2016-11-02
NZ72583516 2016-11-02
NZ72583716 2016-11-02

Publications (1)

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WO2017153865A1 true WO2017153865A1 (fr) 2017-09-14

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KR (1) KR20180131564A (fr)
AU (1) AU2017230983A1 (fr)
BR (1) BR112018068083A2 (fr)
CA (1) CA3031581A1 (fr)
WO (1) WO2017153865A1 (fr)

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CN109703720A (zh) * 2018-12-29 2019-05-03 无锡海核装备科技有限公司 一种双层舱盖置物装置
WO2021239751A1 (fr) * 2020-05-28 2021-12-02 Allflex Europe Sas Dispositif d'échantillonnage pour le stockage d'au moins un échantillon de tissu animal, procédé correspondant de collecte et système d'identification d'un animal
USD952897S1 (en) 2020-05-28 2022-05-24 Allflex Europe Sas Collection tube for laboratory analysis
USD974589S1 (en) 2021-01-18 2023-01-03 Allflex Europe Sas Collection tube for laboratory analysis

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CN117330350B (zh) * 2023-11-20 2024-05-07 河北香宇肉类制品有限公司 一种肉质食品检测用样品提取装置

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US20080064983A1 (en) * 2006-09-08 2008-03-13 Jenrik Ag, Llc Livestock tissue identification method and device
US20110295148A1 (en) * 2008-12-10 2011-12-01 Jean-Jacques Destoumieux Device for collecting a tissue sample from an animal
US20120010526A1 (en) * 2008-12-19 2012-01-12 Jean-Jacques Hilpert Device for sampling tissue from an animal and corresponding storage means
US20130204159A1 (en) * 2010-06-09 2013-08-08 Allflex Europe Tool for collecting a sample of animal tissue
WO2014196877A1 (fr) * 2013-06-05 2014-12-11 Snpshot Trustee Limited Améliorations apportées à des dispositifs de prélèvement de tissus
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Publication number Priority date Publication date Assignee Title
CN109703720A (zh) * 2018-12-29 2019-05-03 无锡海核装备科技有限公司 一种双层舱盖置物装置
CN109703720B (zh) * 2018-12-29 2024-03-26 无锡海核装备科技有限公司 一种双层舱盖置物装置
WO2021239751A1 (fr) * 2020-05-28 2021-12-02 Allflex Europe Sas Dispositif d'échantillonnage pour le stockage d'au moins un échantillon de tissu animal, procédé correspondant de collecte et système d'identification d'un animal
USD952897S1 (en) 2020-05-28 2022-05-24 Allflex Europe Sas Collection tube for laboratory analysis
USD974589S1 (en) 2021-01-18 2023-01-03 Allflex Europe Sas Collection tube for laboratory analysis

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AU2017230983A1 (en) 2018-10-25
KR20180131564A (ko) 2018-12-10
BR112018068083A2 (pt) 2019-01-08
CA3031581A1 (fr) 2017-09-14

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