WO2017134679A8 - Novel crystalline polymorphs of 4-[(2,4-dichloro-5-methoxvphenzl)amino] 6-methoxz-7-[3-(4-methyl-1-piperazinzl)propoxzl-3-quinolinecarbonitrile and process for preparation thereof - Google Patents

Novel crystalline polymorphs of 4-[(2,4-dichloro-5-methoxvphenzl)amino] 6-methoxz-7-[3-(4-methyl-1-piperazinzl)propoxzl-3-quinolinecarbonitrile and process for preparation thereof Download PDF

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Publication number
WO2017134679A8
WO2017134679A8 PCT/IN2017/000024 IN2017000024W WO2017134679A8 WO 2017134679 A8 WO2017134679 A8 WO 2017134679A8 IN 2017000024 W IN2017000024 W IN 2017000024W WO 2017134679 A8 WO2017134679 A8 WO 2017134679A8
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WO
WIPO (PCT)
Prior art keywords
quinolinecarbonitrile
dichloro
amino
methyl
preparation
Prior art date
Application number
PCT/IN2017/000024
Other languages
French (fr)
Other versions
WO2017134679A1 (en
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Gogulapati Venkata Panakala Rao
Thippireddy PURNA CHANDRASEKHAR REDDY
Boge RAJESHAM
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Publication of WO2017134679A1 publication Critical patent/WO2017134679A1/en
Publication of WO2017134679A8 publication Critical patent/WO2017134679A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel crystalline polymorphs of 4-[(2,4-dichloro-5- methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile represented by the following structural formula- 1 and process for preparation thereof.
PCT/IN2017/000024 2016-02-03 2017-01-31 Novel crystalline polymorphs of 4-[(2.4-dichioro-5-methoxvphenvl)aniinol- 6-methoxv-7-13-(4-methyl-l-piperazinvl)propoxvl-3-quinolinecarbonitrile and process for preparation thereof WO2017134679A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641003762 2016-02-03
IN201641003762 2016-02-03

Publications (2)

Publication Number Publication Date
WO2017134679A1 WO2017134679A1 (en) 2017-08-10
WO2017134679A8 true WO2017134679A8 (en) 2018-03-01

Family

ID=59499569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2017/000024 WO2017134679A1 (en) 2016-02-03 2017-01-31 Novel crystalline polymorphs of 4-[(2.4-dichioro-5-methoxvphenvl)aniinol- 6-methoxv-7-13-(4-methyl-l-piperazinvl)propoxvl-3-quinolinecarbonitrile and process for preparation thereof

Country Status (1)

Country Link
WO (1) WO2017134679A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110317168A (en) * 2018-03-30 2019-10-11 正大天晴药业集团股份有限公司 A kind of purification process of bosutinib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080027275A (en) * 2005-06-24 2008-03-26 와이어쓰 4-anilino-3-quinolinecarbonitriles for the treatment of cancer
RU2007148072A (en) * 2005-07-01 2009-08-10 Вайет (Us) CRYSTAL FORMS 4 - [(2,4-DICHLOR-5-METHOXYPHINYL) AMINO] -6-MEOXY-7- [3- (4-METHYL-1-PIPERAZINYL) PROPOXY] -3-HINALINCARBONITRIL AND METHODS
IN2014CH00840A (en) * 2014-02-20 2015-09-18 Apotex Inc

Also Published As

Publication number Publication date
WO2017134679A1 (en) 2017-08-10

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