WO2017105043A1 - Silicone rubber composition for producing artificial scalp pad, artificial scalp pad for hair transplant training using said composition, artificial hair follicular unit for hair transplant training and method for producing same, and hair transplant training system capable of measuring and analyzing implantation strength - Google Patents

Abstract

The present specification discloses a silicone rubber composition for producing an artificial scalp pad, an artificial scalp pad for hair transplant training using same, an artificial hair follicular unit for hair transplant training and a method for producing same, and a hair transplant training system capable of measuring and analyzing implantation strength. The artificial scalp pad for hair transplant training produced using the silicone rubber composition according to the present invention has physical properties that are very similar to those of the scalp of the human body, can similarly realize the upper or side part of the head through a mold press method, and has an excellent supply rate by allowing for mass production. Also, the artificial hair follicular unit according to one aspect of the present invention imitates real hair follicles and thus can be utilized in hair transplant training. Further, the hair transplant training system capable of measuring and analyzing implantation strength according to another aspect of the present invention measures and displays the implantation strength of hairs in real time during hair transplant training, further displays the measured implantation strength so as for same to be comparatively analyzed and monitored, and can thereby further improve the effect of the hair transplant training.

Description

Silicone rubber composition for artificial scalp pad manufacturing, artificial scalp pad for hair transplantation training, artificial hair follicle unit for hair transplantation training and its manufacturing method, hair transplantation training system which can measure and analyze implantation force

The present invention relates to a silicone rubber composition for preparing artificial scalp pads and artificial scalp pads for training hair transplantation using the same, and more particularly, to a silicone polymer having a functional group capable of crosslinking with a peroxide, a silica-based filler, and The present invention relates to a silicone rubber composition for preparing an artificial scalp pad having a transplantation sensitivity most similar to a human scalp by including a peroxide in a predetermined amount, and an artificial scalp pad for hair transplantation training using the same.

In another aspect, the present invention relates to an artificial hair follicle unit for hair transplantation training and a method for manufacturing the same, more specifically, hair that can be utilized for hair transplantation training by imitating actual hair follicles using silicone or hydrogel. The present invention relates to an artificial hair follicle unit for transplant training and a method of manufacturing the same.

In addition, the present invention relates to a training system for training a hair transplant in another aspect, and in detail to measure and display the holding force of the hair in real time during training of the hair transplant, and also to measure the measured holding force The present invention relates to a hair transplantation training system that can measure and analyze the grip force, which can further improve the hair transplant training effect by showing comparative analysis.

According to the Korea Health Insurance Review & Assessment Service, the average annual growth rate of hair loss patients over the past five years (2009 ~ 2013) was 3.6%. As the number of hair loss patients increases, various products such as shampoos and herbal medicines to solve hair loss have emerged on the market, and demand for aggressive treatment of hair loss through hair transplant surgery with high engraftment rate is increasing. In addition, when hair or hair is lost to the human skin due to a disease or accident, live or artificial hair is transplanted to the hair or the hair where the hair is lost. In this case, eyebrows, beards, pubic hair, and hair are transplanted using a hair transplanter. You will be planted.

There are two types of hair transplants, incision and non-incision, which are the best treatment method through the trained doctor's training and the simulation suitable for each patient in that there are many scars, the back of the head is not natural and the recovery is slow. Need to prepare for. In addition, non-incisional hair transplantation is a method that separates hair follicles one by one and transplants them to the hair loss area so that there is no scar and can return to daily life immediately after surgery, but it is highly preferred but requires very sophisticated surgical techniques. Therefore, since the skill of the doctor has a great influence on the procedure, much experience is required for the hair transplant specialist. However, the cost of non-incisional hair transplant surgery is very high, so the number of patients actually undergoing surgery and the number of patients undergoing surgery are difficult, so it is not easy for a hair transplant specialist to gain experience. In order to improve the performance of the hair transplant specialist, artificial scalp pads for training hair transplantation are required, but only scalp for wigs such as Korean Patent Publication No. 2010-0052863 has been developed. No scalp pads with similar hair scalp properties for training hair transplantation have been developed. Dr. world-renowned American In Parsa Hohebi's hair clinic, the mannequin's hair is covered with silicone and practiced. This practice has the disadvantage that a hair transplant specialist cannot prepare a lot of training. Therefore, there is a need to develop an artificial scalp pad for training hair transplantation having physical properties similar to human scalp, which can improve hair transplantation techniques of hair transplant specialists.

In addition, since conventional hair follicle training for hair transplantation does not exist separately, hair follicle grafts collected from hair loss patients had to be used during hair transplantation training, and thus the amount of hair follicles to be used for training was insufficient. Therefore, the development of artificial hair follicles similar to actual hair follicles, which can be used for hair transplantation training, is urgently needed.

On the other hand, in single hair transplantation, hair roots are separated one by one and transplanted by needles of the hair transplanter, so there is no bleeding and scars, and the direction, angle and density of the hair can be arbitrarily adjusted, so the hair shape after surgery is naturally maintained. It is also widely used for eyebrows, beards, eyelashes, and pubic hair.

The hair transplanter is a hair root, which is connected to the hair during hair transplantation, is placed in front of the inside of the planter, and then inserted into the scalp. It sits in the scalp. In particular, in order to push the hair roots into the skin tissue in the scalp, a method of using a slidable rod that is slidably movable inside of the hair stick and forming a protruding guide plate acting like a tail stick on the front of the sliding member to guide the hair stick back out. Are no longer brought out by.

When hair transplanting with a hair transplanter, the skin tissue in the human scalp is different in thickness, so the operator must experience and control the insertion force of the mother hair inserted into the scalp by experience. Too weak a holding force can not be reliably planted, too strong damage to the scalp tissue will cause excessive bleeding or inflammation. Since the scalp layer is different according to the individual scalp and the positioning force must be finely adjusted according to the position of the head image, training using a hair transplanter is required.

However, since the conventional hair transplantation training system was not invented separately, the graft force was measured using a general-purpose sheet pressure distribution measurement module, and the hair transplantation training was performed with a separate artificial scalp pad, but the graft force was measured in real time. It could not provide the result of the analysis, which was insufficient for proper training.

(Patent Document 1) Korean Patent Publication No. 2010-0052863

It is an object of the present invention to artificially include 100 parts by weight of a silicone polymer having a functional group capable of crosslinking reaction with a peroxide at the terminal or side and side or side chains, 1 to 30 parts by weight of silica-based filler and 0.05 to 5 parts by weight of peroxide. It is to provide a silicone rubber composition for producing a scalp pad.

Another object of the present invention is to provide an artificial scalp pad wherein the silicone rubber composition is cured onto a pad.

In addition, another object of the present invention is to provide a method of manufacturing the artificial scalp pad.

In another aspect, an object of the present invention is to provide an artificial hair follicle unit for hair transplantation training that can be utilized for hair transplantation training by imitating actual hair follicles using silicone or hydrogel.

In addition, another object of the present invention to provide a method for producing a hair follicle training artificial hair follicle unit for simulating the appearance and placement sensitivity of the actual hair follicle using a silicone or hydrogel.

In addition, in another aspect, an object of the present invention is to measure and display the hair holding force in real time during training of hair transplantation, and to display the comparative analysis by monitoring the measured insertion force, hair transplant training effect It is to provide a hair transplant training system that can measure and analyze the force of implantation to further improve the quality of the implant.

The inventors of the present invention, while studying to develop artificial scalp pads for hair transplantation training having properties similar to human scalp, include a specific content of a silicone polymer, a silica-based filler, and a peroxide having a functional group capable of crosslinking with a peroxide. The present invention has been completed by developing an artificial scalp pad having hardness similar to that of the human scalp and having a transplantation sensitivity that is also satisfied by hair transplant specialists.

In order to achieve the object of the present invention, the present invention is 100 parts by weight of the silicone polymer having a functional group capable of cross-linking reaction with a sock end, or side end and side chain, or side chain, silica-based filler 1 to 30 parts by weight and Provided is a silicone rubber composition for preparing an artificial scalp pad comprising 0.05 to 5 parts by weight of peroxide.

The functional group capable of crosslinking with the peroxide may be at least one selected from the group consisting of vinyl group, allyl group, (meth) acryloyl group, and carboxyl group.

The silicone polymer may include 0.005 to 0.5 mol% of a functional group capable of crosslinking with the peroxide, and may be represented by the following Chemical Formula 1.

[Formula 1]

R _a SiO _{(4-a) / 2}

In Chemical Formula 1,

R is a functional group which crosslinks with a peroxide, or an aliphatic saturated hydrocarbon group having 1 to 10 carbon atoms, an aliphatic unsaturated hydrocarbon group having 1 to 10 carbon atoms, or an aromatic unsaturated hydrocarbon group having 1 to 30 carbon atoms, and a is 1.90 to 2.05 It is positive.

The present invention provides an artificial scalp pad in which the silicone rubber composition is molded onto a pad.

The artificial scalp pad can be used for hair transplant training.

The artificial scalp pad may have a Shore A hardness of 15 to 45 and an elongation of 700 to 1000%.

The present invention relates to a silicone rubber comprising 100 parts by weight of a silicone polymer having a functional group capable of crosslinking reaction with a sock end or a sock end and a side chain, or a side chain, 1 to 30 parts by weight of a silica-based filler, and 0.05 to 5 parts by weight of a peroxide. Mixing the composition, and molding and curing the mixed silicone rubber composition in the shape of a pad, it provides a method for producing a hair scalp training artificial scalp pad.

In addition, the present invention provides a human hair follicle training artificial hair follicle unit, including a human hair or artificial hair, and a hair follicle formed at one end of the human hair or artificial hair in order to achieve the object of the present invention.

In one embodiment of the present invention, the hair follicle portion may be one containing a silicone or a hydrogel.

The artificial hair follicle unit may include one or more human hairs or artificial hairs.

In another aspect, to achieve another object of the present invention, the present invention provides a first step of preparing the human hair or artificial hair to be about 2 cm or more in length, one end of the human hair or artificial hair in a silicone paste or hydrogel solution The second step of applying a silicone paste or hydrogel solution to one end of the human hair or artificial hair by immersing, and curing the human hair or artificial hair coated with the silicone paste or hydrogel solution to form hair follicles at one end of the human hair or artificial hair It provides a method for producing a hair follicle training artificial hair follicle unit comprising a third step.

In one embodiment of the present invention, the silicon paste may be one liquid containing room temperature curing silicone.

The hydrogel solution may be one containing gelatin or alginate.

The second step may be to immerse one end of the human hair or artificial hair to a depth of about 0.1 cm to about 1 cm in the silicone paste or hydrogel solution.

When the hydrogel solution is applied to one end of the human hair or artificial hair in the second step, the hardening of the third step may be performed in an aqueous solution containing a curing agent.

One or more human hairs or artificial hairs may be included in the artificial hair follicle unit.

In addition, the present invention, the mounting force detection pad to which the scalp pad is seated and outputs a detection signal according to the insertion force applied to the scalp pad, the mounting force detection pad is seated, the height and rotation of the mounting force detection pad is seated And a pad stand for adjusting the inclination of at least one axis, and measuring the holding force in real time through a detection signal and controlling the measured holding force to be displayed on the at least one monitor, as well as measuring the holding force measured during the preset period. It provides a hair transplantation training system that can measure and analyze a grip force, including a main controller that displays and controls the data to be monitored and compared with pre-stored evaluation data or expert data.

Artificial scalp pad made of the silicone rubber composition according to the present invention has a very similar physical properties to the human scalp, and can implement the upper head or the side of the head through a mold press method, and because the mass production is possible, the diffusion rate is excellent, Hair transplant specialists who need hair transplant training can help them gain practical experience.

In addition, conventional hair follicle training artificial hair follicles do not exist separately because the actual hair follicles collected from the scalp of the hair loss patient to be used only for hair transplant training, but the supply of hair follicles was not very good, according to the present invention, hair transplant training The doctor can provide artificial hair follicles similar to the actual hair follicles, which can solve the problem of shortage of hair transplant training hair follicles.

In addition, according to the hair transplantation training system that can measure and analyze the grip force of the present invention, the hair transplantation training can be measured and displayed in real time while training the hair transplant, and the measured grip force can be displayed by comparing and analyzing the measured grip force. By doing so, the hair transplant training effect can be further improved. In particular, the training effect can be further improved by displaying a screen for monitoring the insertion force in real time while training the hair transplant and by listening to a sound corresponding to the insertion force during the insertion. In addition, it is possible to reduce the development cost and manufacturing cost by allowing the unit cost to be measured by lowering the unit cost without using an expensive general purpose sheet type pressure distribution measurement module. In addition, by replacing the sensor pad to suit the training site can be supported to perform a customized training for each site.

1 is a schematic diagram briefly showing a method of manufacturing an artificial scalp pad using a silicone rubber composition.

2 is a photograph of a mold used when manufacturing an artificial scalp pad as an example.

3 is a photograph of the artificial scalp pad prepared in the embodiment.

Figure 4 shows an artificial hair follicle unit for hair transplantation training according to an embodiment of the present invention.

Figure 5 shows a method for producing a hair follicle training artificial hair follicle unit according to an embodiment of the present invention.

Figure 6 is an image of a hair follicle training artificial hair follicle unit prepared according to an embodiment of the present invention.

7 is an image of a hair follicle training artificial hair follicle unit manufactured according to an embodiment of the present invention.

8 is a block diagram showing a hair transplantation training system capable of measuring and analyzing the grip force according to an embodiment of the present invention.

FIG. 9 is a side view illustrating the pad stand shown in FIG. 8 in detail.

FIG. 10 is a front view of the pad stand illustrated in FIG. 9 in detail.

FIG. 11 is a block diagram illustrating the main controller shown in FIG. 8 in detail.

FIG. 12 is a graph showing the sum of the insertion pressures according to the insertion force data and the evaluation data analyzed by the main controller of FIG. 11.

FIG. 13 is a graph illustrating a maximum implantation pressure value according to the implantation force data and the evaluation data analyzed by the main controller of FIG. 11.

FIG. 14 is an analysis screen showing different insertion force data analyzed by the main controller. FIG.

DETAILED DESCRIPTION Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and like reference numerals designate like parts throughout the specification.

The terms or words used in the specification and claims of the present invention are not to be construed in a conventional or dictionary sense, and the inventors may appropriately define the concept of terms in order to best explain their invention in the best way. Based on the principle, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

* Throughout the specification of the present invention, when a part is said to "include" a certain component, it means that it may further include other components, except to exclude other components unless specifically stated otherwise. do.

In the specification of the present invention, "A and / or B" means A or B, or A and B.

Throughout the specification of the present invention, the term "human hair" refers to hair collected from the human body, and "human hair" refers to fibers artificially manufactured to have a similar appearance and placement sensitivity to human hair.

The present invention is an artificial scalp including 100 parts by weight of a silicone polymer having a functional group capable of crosslinking reaction with a sock end or a side end, or a side chain, or a side chain, 1-30 parts by weight of a silica-based filler, and 0.05-5 parts by weight of a peroxide. Provided is a silicone rubber composition for pad preparation.

The silicone polymer contained in the silicone rubber composition of the present invention contains a functional group capable of crosslinking reaction with a peroxide, and can be used in both linear or branched chains. Because it contains the functional group, it can be cured by reacting with the peroxide to form a crosslinked structure.

The functional group capable of crosslinking with the peroxide is not limited thereto, but may be one or more selected from the group consisting of vinyl group, allyl group, (meth) acryloyl group, and carboxyl group, and preferably vinyl group. .

The silicone polymer may include 0.005 to 0.5 mol% of a functional group capable of crosslinking with the peroxide, and may be represented by the following Chemical Formula 1.

[Formula 1]

R _a SiO _{(4-a) / 2}

In Chemical Formula 1,

R is a functional group which crosslinks with a peroxide, or an aliphatic saturated hydrocarbon group having 1 to 10 carbon atoms, an aliphatic unsaturated hydrocarbon group having 1 to 10 carbon atoms, or an aromatic unsaturated hydrocarbon group having 1 to 30 carbon atoms, and a is 1.90 to 2.05 It is positive.

The content of the functional group may be 0.005 to 0.5 mol%, 0.005 to 0.4 mol%, 0.005 to 0.3 mol%, 0.01 to 0.5 mol%, 0.01 to 0.4 mol%, or 0.01 to 0.3 mol%. If the functional group content is less than 0.005 mol%, the curing is not sufficiently made, the rubber is too soft, and if it exceeds 0.5 mol%, the crosslinking point is excessively formed and the hardness becomes larger than necessary.

The silica filler included in the silicone rubber composition of the present invention is an amorphous finely divided synthetic silica filler, which may be either wet or dry silica, and more preferably dry silica. Dry silica can make the physical properties of the silicone rubber composition according to the present invention similar to human scalp with less content than wet silica.

Silica fillers 1-30 parts, 1-25 parts, 1-20 parts, 1-15 parts, 1-10 parts, 4-30 parts, 4-25 parts, 4-20 parts 4 to 15 parts by weight, 4 to 10 parts by weight, 7 to 30 parts by weight, 7 to 25 parts by weight, 7 to 20 parts by weight, 7 to 15 parts by weight, or 7 to 10 parts by weight. If the content is less than 1 part by weight or the hardness is too weak, and if it exceeds 30 parts by weight, the physical properties are not similar to the human scalp because the hardness becomes excessively large and elongation is decreased. In addition, when it exceeds 30 parts by weight, silica dispersion may not be good.

The peroxide included in the silicone rubber composition of the present invention is a substance which forms a crosslink by forming a radical reaction on a functional group capable of crosslinking with the peroxide of the silicone polymer, and an organic peroxide may be preferable. Specific examples may be one or more selected from the group consisting of 2,5-dimethyl-2,5-t-butylhexane peroxide, 2,4-dichlorobenzoyl peroxide, benzoyl peroxide and combinations thereof.

The peroxide content is 0.05 to 5 parts by weight, 0.05 to 4 parts by weight, 0.05 to 3 parts by weight, 0.05 to 2 parts by weight, 0.05 to 1 part by weight, 0.1 to 5 parts by weight, 0.1 to 4 parts by weight, 0.1 to 3 parts by weight. Parts, 0.1 to 2 parts by weight, or 0.1 to 1 part by weight. If the peroxide content is less than 0.05 parts by weight, the crosslinking is not sufficiently formed so that the physical properties of the silicone polymer do not change significantly. If the peroxide content exceeds 5 parts by weight, the physical properties of the silicone rubber composition according to the present invention are not similar to that of the human scalp. Residual peroxide removal work is time consuming.

The rubber composition of the present invention is crosslinked with a peroxide, as shown in the following figure (source: http://www.wacker.com/cms/en/products/product_groups/silicone_rubbers_1/vernetzung_1.jsp) A functional group (vinyl group) reacts with the peroxide to form a crosslinked structure.

Silica-based fillers are settled in the resulting crosslinked structure to change the physical properties of the silicone polymer. At this time, the silicone polymer, peroxide and silica-based filler should be mixed in the weight range specified by the present invention, the silicone rubber composition according to the present invention may have properties similar to the human scalp.

The silicone rubber composition according to the present invention may further include a pigment as a colorant, but is not limited to 0.01-20, 0.01-15, 0.01-10, 0.01-5, or 0.01-1 of 100 parts by weight of the silicone polymer. It may be included in parts by weight. If it is less than 0.01, the color may not be properly formed, and if it exceeds 20 parts by weight, the physical properties of the silicone rubber composition according to the present invention may not be similar to the human scalp.

The present invention provides an artificial scalp pad in which the silicone rubber composition is molded onto a pad. Hair transplant specialists have evaluated that the artificial scalp pad of the present invention has similar physical properties to the human scalp, and in fact, the human scalp and the artificial scalp pad of the present invention have similar hardness. Because it has properties similar to human scalp, it can provide hair transplant trainers with a realistic environment.

The artificial scalp pad according to the present invention may have shore A hardness of 15 to 45, 20 to 45, 25 to 45, 30 to 45, 15 to 40, 20 to 40, 25 to 40, or 30 to 40. , Elongation can be 700-1000%, 750-1000%, 700-900%, 750-900%, or 750-850%. As the property values satisfy all of the above ranges, the artificial scalp pad according to the present invention has properties similar to human scalp.

The present invention provides a method for producing artificial scalp pad for hair transplantation training using the silicone rubber composition according to the present invention. In the production method of the present invention, 100 parts by weight of the silicone polymer having a functional group capable of crosslinking reaction with the sock end or the sock end and the side chain, or the side chain, 1 to 30 parts by weight of the silica-based filler, and 0.05 to 5 parts by weight of the peroxide Mixing the silicone rubber composition comprising; and molding and curing the mixed silicone rubber composition into a pad shape.

Before the silicone rubber composition is molded and cured into a pad shape, the silicone rubber composition may be aged at room temperature for about 12 to 48 hours. In addition, the molding and curing is at a temperature of 50 ~ 300 ℃, 50 ~ 250 ℃, 50 ~ 200 ℃, 50 ~ 150 ℃, 100 ~ 300 ℃, 100 ~ 250 ℃, 100 ~ 200 ℃, or 100 ~ 150 ℃ It may be made at the same time, the forming method is not limited to this, but may be compression molding.

In another aspect, the present invention provides a human hair follicle training artificial hair follicle unit, including a human hair or artificial hair, and a hair follicle formed at one end of the human hair or human hair.

In one embodiment of the present invention, the hair follicle portion may be one containing a silicone or a hydrogel.

The hair follicles have a hardness (KS M 6518: 2006) of about 10 to about 50 or about 25 to about 40, and a percent rebound elasticity of about 10% to about 50% or about 15% to about 25%. It may be, but may not be limited thereto. Hardness less than 10 is a jelly level so that the hardness is too low to maintain the shape when implanted, when the hardness is 10 to 50, the hair follicles do not break during the implantation can implement a feeling of similarity to the placement of the actual hair follicles. The elasticity of the hair follicles is also important for the implantation simulation, and maintaining the elasticity of 50% or less is suitable for the implantation simulation.

The human hair or artificial hair may have a length of about 2 cm to about 5 cm or about 2 cm to about 3 cm.

The hair follicles may have a length of about 0.1 cm to about 1 cm and a thickness of about 200 μm to about 500 μm. If the length and thickness satisfy the above-mentioned range, it is suitable to mimic the appearance of actual hair follicles.

Thus, according to the present invention can solve the problem of supply shortage of hair transplant training hair follicles. Conventionally, when collecting grafts for hair transplant surgery, hair follicles used for training of medical personnel were collected and hair follicles were collected from the scalp of the hair loss patient compared to the number of hair follicles used for transplantation, but for hair transplantation training according to an embodiment of the present invention. The commercialization of artificial hair follicle units will reduce the amount of grafts from the scalp of hair loss patients, thereby reducing the patient's rejection of the hair collection process.

The artificial follicular unit may comprise one or more human or artificial hairs. When the artificial hair follicle unit includes one human hair or artificial hair, it is referred to as a 'type 1 artificial hair follicle unit', and when the artificial hair follicle unit includes two human hair or human hair, 'Type 2 (Type 2)' ) Artificial hair follicle unit, and when the artificial hair follicle unit includes three human hairs or artificial hairs, it is referred to as a 'type 3 artificial hair follicle unit'.

In this regard, Figure 4 shows an artificial hair follicle unit for hair transplantation training according to an embodiment of the present invention. Referring to FIG. 4, the type 1 artificial hair follicle unit has a thickness of about 200 μm, and the type 2 artificial hair follicle unit has a thickness of about 350 μm, and the type 3 artificial hair follicle unit has a thickness of about 500 μm. This is only an example, and the present invention is not limited thereto.

In addition, the present invention is the first step of preparing the human hair or artificial hair so that the length is about 2 cm or more, by immersing one end of the human hair or artificial hair in the silicone paste or hydrogel solution to the silicone paste or one end of the human hair or artificial hair A second step of applying a hydrogel solution, and a third step of forming a hair follicle at one end of the human hair or the human hair by curing the human hair or the artificial hair to which the silicone paste or the hydrogel solution is applied. Provided are methods for preparing the hair follicle unit.

In this regard, Figure 5 shows a method for producing a hair follicle unit for hair transplant training according to an embodiment of the present invention.

The first step is to take the human hair or artificial hair and cut it to have a length of about 2 cm to about 5 cm.

The second step is a process for applying a silicone paste or hydrogel solution to one end of the human hair or artificial hair, and about 0.1 cm to about 1 cm or about 0.3 cm from one end of the human hair or artificial hair in the silicone paste or hydrogel solution. By soaking briefly to a depth of from about 0.6 cm.

The third step is to prepare artificial hair follicles by curing the silicone paste or hydrogel solution applied to one end of the human hair or artificial hair.

The silicon paste may be made of a one-liquid room temperature-curable silicone, the one-liquid room temperature-curable silicone is one that can be naturally cured at room temperature in the air without a curing agent. The silicon is a polymer (for example, polysiloxane) formed by alternating silicon and oxygen bonds (siloxane bonds), and may be a silicone oil, a liquid silicone rubber, or a silicone resin. It can react with water in the liver or air to cure from the surface to form silicone rubber, which is an elastic solid:

Scheme 1

The silicon preferably has a specific gravity of about 0.5 to about 1.5, but may not be limited thereto.

Meanwhile, the hydrogel solution may include alginate or gelatin. When the hydrogel solution is applied to one end of the human hair or artificial hair in the second step, the hardening of the third step may be performed in an aqueous solution containing a curing agent, and the hydrogel solution is applied to the aqueous solution containing the curing agent. The hair follicle may be formed at one end of the human hair or the human hair by curing the human hair or the human hair in the submerged state.

When the hydrogel solution is an alginate solution containing alginate, one selected from the group consisting of calcium chloride, barium chloride, iron (III) chloride, lead acetate, zinc sulfate, aluminum sulfate, copper sulfate, silver nitrate, and calcium nitrate as the curing agent. The above can be used.

The alginate solution may be about 1 wt% to about 20 wt% of an alginate, and preferably about 4 wt% to about 10 wt%, but may not be limited thereto. At this time, the solvent may include one or more selected from the group consisting of water, alcohol, and PBS (phosphate buffered saline). The water may be distilled water, deionized water or ion exchange water, the distilled water is preferably tertiary distilled water, but is not limited thereto. The alcohol may include one or more selected from the group consisting of ethanol, propanol, butanol, pentanol, and isomers thereof.

In addition, the aqueous solution containing the curing agent may be an aqueous solution having a content of the curing agent of about 10% by weight or less, for example, about 1% by weight to about 3% by weight of an aqueous solution, but may not be limited thereto. In order to mimic the actual sensitivity of the hair follicle to be placed, the alginate content of the alginate solution and the hardener content of the aqueous solution containing the hardener may be adjusted.

For example, the alginate solution applied to the human hair or artificial hair in the second step can be cured by reaction with an aqueous solution of calcium chloride, which is a curing agent, as shown in Scheme 2:

Scheme 2

The alginate may comprise one or more selected from the group consisting of calcium alginate, sodium alginate, barium alginate, potassium alginate, ammonium alginate, propylene glycol alginate, propylene glycol ester alginate, and alginic acid.

Alternatively, when the hydrogel solution is a gelatin solution containing gelatin, glutaraldehyde (GA), formaldehyde, genipin, and water-soluble carbodiimide as the curing agent. One or more selected from the group consisting of can be used.

The gelatin solution may be a gelatin content of about 10% to about 30% by weight, preferably about 15% to about 20% by weight, but may not be limited thereto. At this time, the solvent may include one or more selected from the group consisting of water, alcohol, and PBS. The water may be distilled water, deionized water or ion exchange water, the distilled water is preferably tertiary distilled water, but is not limited thereto. The alcohol may include one or more selected from the group consisting of ethanol, propanol, butanol, pentanol, and isomers thereof.

In addition, the aqueous solution containing the curing agent may be an aqueous solution having a content of the curing agent of about 10% by weight or less, for example, about 1% by weight to about 3% by weight of an aqueous solution, but may not be limited thereto. In order to mimic the placement sensitivity of the actual hair follicles, the hardener content of the aqueous solution containing the gelatin and hardener of the gelatin solution can be adjusted.

For example, the gelatin solution applied to human hair or artificial hair in the second step can be cured by reacting with an aqueous solution of glutaraldehyde, which is a curing agent, as shown in Scheme 3:

Scheme 3

At this time, the curing may be carried out by room temperature curing or heat curing.

In another aspect, the present invention relates to a hair transplantation training system capable of locating force measurement and analysis.

8 is a block diagram showing a hair transplantation training system capable of measuring and analyzing the grip force according to an embodiment of the present invention.

In the hair transplantation training system shown in FIG. 8, an implantation force detection pad 150 and an implantation force detection pad 150 for outputting a detection signal according to an implantation force applied to the scalp pad 160 are mounted on the scalp pad 160. The pad stand 100 to adjust the height, rotation and inclination of the at least one axis on which the grip force detection pad 150 is seated, and a detection signal to measure the grip force in real time and measure the measured grip force. The main controller controls the display to be displayed on the at least one monitor (115,200), and displays and controls the grip force measured for a preset period to be compared and monitored with pre-stored pre-stored evaluation reference data or expert data. 300).

The holding force detecting pad 150 is seated on the upper front seating surface of the pad stand 100, and fixes the scalp pad 160 to the upper front seating surface. A plurality of pressure measuring sensors are arranged on the holding force detection pad 150 to output detection signals according to the pressure and the holding force applied to the scalp pad 160 through respective pressure measuring sensors. The holding force detection pad 150 may be manufactured in various sizes, thicknesses, and shapes, and may be used interchangeably for each form, type, and part of the scalp pad 160.

During hair transplantation training, the scalp pad 160 is seated on the grip force detection pad 150, and the hair is transplanted to the scalp pad 160 using a hair transplanter. Accordingly, the pressure measuring sensors of the holding force detecting pad 150 detect the pressure and the holding force applied to the scalp pad 160 by a hair transplanting mosquito, and connect the analog detection signals corresponding to the pressure and the holding force, respectively. Will output

FIG. 9 is a side view specifically showing the pad stand shown in FIG. 8, and FIG. 3 is a front view specifically showing the pad stand shown in FIG. 2.

As shown in FIG. 9 and FIG. 10, the pad stand 100 adjusts the inclination and rotation of the x, y, z axes of the seating plate 111 and the seating plate 111 on which the grip force detecting pad 150 is seated. Tilt angle control unit 114 to be adjusted, the height control unit 112 to adjust the z-axis height of the mounting plate 111, the support plate for supporting the seating plate 111 and the tilt angle control unit 114 and the height control unit 112 A switch unit 116 for driving the tilt angle control unit 114 and the height control unit 112 to adjust the height, rotation, and inclination of at least one axis of the seating plate 111, and the main controller 300. The sub-monitor 115 displays a result of comparing and analyzing the real-time measuring force and the grip force measured during the preset period with the pre-stored evaluation reference data or expert data according to the control of the control.

The tilt angle control unit 114 is configured such that the circular shaft is fixed to the rear surface of the seating plate 111 and wraps and fixes at least a portion of the circular shaft. Thus, the tilt angle control unit 114 allows the mounting plate 111 to be rotated in a horizontal direction on the ground while adjusting the inclination of the x, y, z axes. The tilt angle control unit 114 may be fixed by a separate fixing screw or nut structure.

The height control unit 112 supports the tilt angle control unit 114 and is fixed to the support unit 113 at the bottom. The height control unit 112 may have a height adjustment structure using a motor or a height adjustment structure using a linear actuator therein to adjust the z axis height of the seating plate 111 and fix the z axis height. In addition, the height control unit 112 may be provided with a height adjustment structure using a hydraulic or pneumatic piston configuration to adjust the z-axis height. When the height control unit 112 is configured to electrically move the piston, the height of the seating plate 111 may be adjusted by electric power under the control of the switch unit 116.

The operator performing the hair transplantation training is sequentially stacked and fixed to the mounting force detection pad 150 and the scalp pad 160 on the seating plate 111, the seating plate according to the procedure posture, the height of the arm and the angle of the arm Adjust the height and tilt of (111). Then, after fixing the adjusted seating plate 111, the hair is implanted into the scalp pad 160 using a hair transplanter.

The main controller 300 converts the analog detection signal input in real time through the grip force detection pad 150 into a digital signal. In addition, the holding force is measured in real time through a digital signal, and the measured holding force is controlled in real time to be displayed on the at least one monitor 115 or 200. In this case, the main controller 300 displays the measurement force measured on the sub-monitor 115 of the pad stand 100 so that the operator can monitor the implantation force while transplanting the hair in real time. In addition, the main controller 300 may control a separate sound device to play a sound corresponding to a holding force measured in real time during training.

The main controller 300 may display the grip force measured during the training period or the preset period in comparison with the previously stored evaluation reference data for monitoring. In this case, the main controller 300 monitors the grip force measurement data measured during the training period or the preset period in comparison to the grip force measurement data of previously performed or stored or expert (or skilled person) data in addition to the pre-stored evaluation reference data. By marking it so that it can be supported to analyze and evaluate the grip force. Here, the pre-stored evaluation reference data is reference pressure data that measures and sets the pressure required to implant the hair for each type of the scalp pad 160 and the site of the scalp pad 160 in advance. The expert data is the pressure data or the average data that the experts and the skilled person have performed before the hair transplant training process and stored in this process.

FIG. 11 is a block diagram illustrating the main controller shown in FIG. 8 in detail.

The main controller 300 illustrated in FIG. 11 may be a hardware device such as a notebook, a personal computer, or a tablet mobile communication device. The main controller 300 may include a signal input unit 310, a monitoring control unit 320, a sound control unit 330, and an insertion force analysis. The unit 340 may include or be configured to include a database 350.

In detail, the signal input unit 310 converts an analog detection signal input in real time from the insertion force detection pad 150 into a digital detection signal.

The holding force analyzing unit 340 measures and shares the holding force in real time through a digital detection signal, and generates evaluation data by comparing and analyzing the holding force data measured during a training period or a predetermined period with pre-stored evaluation reference data. do. In addition, the grip force analysis unit 340 may generate the evaluation data by comparing and analyzing the grip force data measured during the training period or a predetermined period with preset grip force measurement data of the expert, that is, expert data.

The monitoring control unit 320 controls so that the gripping force data measured and analyzed in real time by the gripping force analyzing unit 340 is displayed on at least one monitor 115 or 200. After the training, the evaluation data analyzed by the insertion force analyzing unit 340 is controlled to be displayed on at least one monitor 115 or 200.

The sound control unit 330 generates sound data corresponding to the holding force measured in real time by using the holding force data measured and analyzed in real time by the holding force analyzing unit 340, so that the sound corresponding to the measured holding force in real time is obtained. Support to be generated through sound equipment.

On the other hand, the database 350 is a real-time measurement and analysis of the gripping force data, preset evaluation reference data, expert data, pre-executed gripping force measurement data, and evaluation data generated by the gripping force analysis unit 340 Save and share and support in real time.

FIG. 12 is a graph showing the sum of the insertion pressures according to the insertion force data and the evaluation data analyzed by the main controller of FIG. 11.

Although the gripping force analyzing unit 340 of the main controller 300 measures the gripping force in real time and controls the gripping force in real time so that the measured gripping force is displayed on the at least one monitor 115 or 200, as shown in FIG. The grip force analysis unit 340 of the controller 300 may generate evaluation data so that the grip force data measured during a training period (or a preset period) may be compared with previously stored evaluation reference data and displayed in a graph. . In addition, the monitoring control unit 320 displays the evaluation data on the at least one monitor 115 or 200 so that the operator can check.

Thus, the trained practitioner can compare and confirm the data of the expert's total implant pressure and the result of the operator's own implant pressure through the analyzed parameters. Or, you can compare and confirm the results of the total implant pressure and expert's own implant pressure.

FIG. 13 is a graph illustrating a maximum implantation pressure value according to the implantation force data and the evaluation data analyzed by the main controller of FIG. 11.

As shown in FIG. 13, the grip force analyzing unit 340 of the main controller 300 compares the maximum value of the grip pressure measured during a training period (or a preset period) with data that is stored in advance. Evaluation data can also be generated for graphical display.

Thus, the trained practitioner can compare and confirm the maximum pressure data of the skilled person and the maximum pressure data of the operator himself through the analyzed parameters. Or, it is possible to compare and confirm the maximum pressure data of the expert data and the maximum pressure data of the own data.

14 is an analysis screen showing different insertion force data analyzed by the main controller.

The holding force analyzing unit 340 of the main controller 300 may measure the holding force in real time and generate the holding force data and the evaluation data so that the measured holding force may be displayed in various forms on the at least one monitor 115, 200. Can be. In particular, depending on the installation pressure value, it can be displayed in various spatial forms so that the installation pressure can be immediately checked for each placement position.

As described above, the implantation force analysis unit 340 is various in the form of two-dimensional space, three-dimensional graph, three-dimensional space, etc. in addition to the two-dimensional graph so that the operator can monitor the implantation force to transplant the hair while transplanting the hair in various forms The holding force data is generated to be displayed.

Accordingly, the operator can variously select and set the etch force data display screen, and analyze and monitor the etch force data measured in real time in a desired form. In this case, the insertion force analysis unit 340 may be variously displayed in the form of two-dimensional space, three-dimensional graph, three-dimensional space, etc. in addition to the two-dimensional graph evaluation data compared with the measurement force of the skilled person (or, expert) It can be created and displayed so that it can be accurately analyzed and evaluated.

According to the hair transplantation training system capable of measuring and analyzing the grip force of the present invention as described above, the hair grip training is measured and displayed in real time while training the hair transplant, and the measured grip force is compared and monitored. By making it possible, the hair transplant training effect can be further improved. In particular, the training effect can be further improved by displaying a screen for monitoring the insertion force in real time while training the hair transplant and by listening to a sound corresponding to the insertion force during the insertion.

In addition, it is possible to reduce the development cost and manufacturing cost by allowing the unit cost to be measured by lowering the unit cost without using an expensive general purpose sheet type pressure distribution measurement module. In addition, by replacing the sensor pad to suit the training site can be supported to perform a customized training for each site.

[Description of the code]

100: pad stand 111: seating plate

112: height control portion 113: support portion

114: tilt angle control unit 115: sub monitor

116: switch unit 150: insertion force detection pad

160: scalp pad 200: main monitor

300: main controller 310: signal input unit

320: monitoring control unit 330: sound control unit

340: insertion force analysis unit 350: database

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples in accordance with the gist of the present invention to those skilled in the art. Will be self-evident.

Artificial Scalp Composition and Artificial Scalp

<Production of Example>

1. Manufacture of Silicone Rubber Pads Using Commercial Products

Rubber pads were manufactured according to the procedure of FIG. 1 as a commercially available product in order to find out the components necessary for manufacturing an artificial scalp and physical composition similar to the human scalp.

Each component was first weighed with an electronic balance (Precisa XT 220A). In the case of mixing, degassing was carried out with a vacuum pump (Millipore WP6111560) for degassing, and 10 to 30 minutes of mixing was performed at a speed of 100 to 300 rpm depending on the type of silicon using a stirrer (magnetic stirrer or motor stirrer). After the completion of mixing, the mixture was aged at room temperature for one day (aging by defoaming as needed), and the thickness was 1.5 ± 0.5 cm by curing at a constant pressure for 5 to 10 minutes using a simple system with heating at 100 to 200 ° C. Silicone rubber pads were prepared. Afterwards, the physical properties of the silicone rubber pad were measured, and a hair transplantation expert evaluated the sensitivity of upper, middle, and lower sensitivity (up: very similar, down: very heterogeneous) whether the silicone rubber pad gave a feeling similar to the human scalp. The results are shown in Table 1 below.

Evaluation of the composition (unit: parts by weight), physical properties and sensitivity of the product to be evaluated

ingredient		Product A	Product B	Product C	Product D
Formulation		Liquid silicone	Silicone elastomer	Silicone elastomer	Silicone elastomer
Silicone polymer		100	60-90	60-90	30-60
Silica filler		-	10-30	10-30	30-60
Crosslinking catalyst	platinum	-	○	-	-
	peroxide	-	-	○	○
Shore A Hardness		30	36	37	66
Elongation (%)		600	1117	810	560
Sensitivity evaluation		Ha	medium	Prize	Ha
* Product A: DOW CORNING® 3730 A & B KIT * Product B: DOW CORNING® C6-135 ELASTOMER, KIT * Product C: DOW CORNING® C6-235 ELASTOMER * Product D: DOW CORNING® C6-265 ELASTOMER

Elongation was very low for product A without crosslinking reaction, and thus scored very low in sensitivity evaluation. In addition, products B and C differ only in the mechanism of crosslinking reaction, and product C using peroxide has a better sensitivity evaluation than product B using platinum catalyst. Therefore, it turns out that it is more preferable to use a peroxide for crosslinking reaction. In addition, product D used the same peroxide catalyst as product C, but received very low sensitivity evaluation. These results indicate that when the silica-based filler is relatively very high in comparison with the silicone polymer, the sensitivity of the silicone rubber pad and the human scalp is greatly changed.

Looking at the physical properties of the pad in Table 1, in order to have a sensitivity similar to the human scalp, it can be seen that Shore A hardness of 15 to 45, elongation (%) is preferably 700 to 1000%.

2. Example  Produce

In order to manufacture an optimal artificial scalp pad based on Table 1, an example having the composition of Table 2 was produced, and the manufacturing method was prepared by the same method as the pad manufactured from the commercially available product. As a method of preparing a silicone rubber composition, a general rubber manufacturing method was used. First, a silicone polymer was added to Kneader 75L (Rosin ratio Front 30 rpm / Rear 34 rpm) of Bongsin Co., Ltd. After about 3 minutes of soaking while maintaining, the silica-based filler and pigment were further added and mixed for about 6 minutes. Secondary kneading is carried out for about 4 ~ 5 minutes while maintaining the coolant temperature at 15 ~ 25 ℃ in Bongsin Co., Ltd. The third kneading process was sequentially performed for about 4 minutes while maintaining the coolant temperature at 15 to 25 ° C. in the 16 inch roller. The silicone composition, which has undergone all kneading processes, is aged for at least one day after cutting 30 cm x 30 cm, and cured for 5 to 10 minutes using a mold shown in FIG. 2 at a constant pressure with heating at 100 to 200 ° C. A pad (thickness: about 1.5 ± 0.5 cm) was produced. Artificial scalp pads made from the compositions of Examples 1 to 3 are shown in FIG. 3.

Composition of Examples (Unit: parts by weight)

	Example 1	Example 2	Example 3
Silicone polymer	100	100	100
Silica filler	3	5	10
Peroxide Crosslinking Agent	0.5	0.5	0.5
Pigment	0.02	0.02	0.02
1) Silicone polymer: poly (dimethylsiloxane), vinyl terminated 2) Silica filler: Amorphous dry silica filler

Experimental Example

Experimental Example 1: Measurement of physical properties of the Example

The basic physical properties of the examples were measured, and the results are shown in Table 3 below.

Basic Physical Properties of Examples and Comparative Examples

	Example 1	Example 2	Example 3
shore A hardness (Hs)	21	29	39
Elongation (%)	840	710	773
importance	1.068	1.093	1.108

In order to have physical properties similar to the human scalp, it was derived from the results of Table 1 that the Shore A hardness is preferably 15 to 45 and elongation (%) is 700 to 1000%. In the results of Table 3, it can be seen that the hardness and elongation of Examples 1 to 3 have hardness and elongation to have properties similar to those of human scalp, and thus Examples 1 to 3 are artificial scalp similar to human scalp. It can be seen that the pad is suitable for manufacturing.

Experimental Example 2: Comparative Example 1 and the hardness of the human scalp (t-test)

In order to find out whether Example 1 is actually similar to the human scalp, the hardness of the Example and the human scalp is measured 10 times using a hardness tester (Shore D Durometer), and the average, standard deviation, and standard error are measured using the measurement results. The calculation is shown in Table 4 below.

	Average	Standard Deviation	Standard error
Human scalp	4.15	1.49	0.47
Example 1	3.95	1.01	0.32

As a result of the t-test (p <0.05), a significant probability p value of 0.731 was obtained, which means that there was no significant difference between the human scalp and the hardness of the embodiment. Therefore, it can be seen that the embodiment is actually very similar to the human scalp.

Artificial hair follicle unit

< Example >

Example  4: Preparation of Artificial Hair Follicle Unit Using Silicone

One end of the human hair cut to about 2 cm was immersed in a neutral curable silicone (negative gravity about 1) paste at a depth of 5 mm, and then artificial hair follicle units were prepared by curing at room temperature for about 30 minutes. The artificial hair follicle unit thus prepared was completely cured by standing at room temperature for 7 days.

Example 4-1 was prepared such that the artificial hair follicle unit comprises 1 strand of human hair, and Example 4-2 was prepared such that the artificial hair follicle unit included 2 strands of human hair. The appearance image of 2 is shown in FIG. 6.

Figure 6 is an image of a hair transplant training artificial hair follicle unit prepared according to the present embodiment, the figure at the top shows the appearance of the actual hair follicle for contrast. Referring to FIG. 6, it can be seen that the hair transplant training artificial hair follicle unit manufactured according to this embodiment has a shape that mimics the appearance of actual hair follicles to have a hair follicle portion of about 5 mm in length and about 200 to 350 μm thick. have.

Example  5: Alginate Preparation of Artificial Hair follicle Units

Immerse the artificial hair follicle unit by dipping the one end of the human hair cut to about 2 cm in an alginate solution to a depth of 5 mm, and curing it for 15 minutes at room temperature while immersing the human hair coated with the alginate solution in an aqueous solution of calcium chloride. Prepared. At this time, the alginate solution was prepared by mixing alginate (Sigma-Aldrich Co., A2033) and calcium chloride (CaCl ₂ , Sigma-Aldrich Co., C5670) as a curing agent at the concentration shown in Table 5, and the solvent of the alginate solution and CaCl ₂ aqueous solution. As distilled water, tertiary distilled water was used. Finally, the artificial hair follicle unit prepared was soaked in tertiary distilled water.

	Alginate Solution Concentration	CaCl 2 aqueous solution concentration
Processing 1	4 wt%	1 wt%
Processing 2	4 wt%	2 wt%
Processing 3	4 wt%	3 wt%
Processing 4	6% by weight	1 wt%
Processing 5	6% by weight	2 wt%
Processing6	6% by weight	3 wt%
Processing7	8% by weight	1 wt%
Processing8	8% by weight	2 wt%
Processing9	8% by weight	3 wt%
Processing10	10% by weight	1 wt%
Processing11	10% by weight	2 wt%
Processing12	10% by weight	3 wt%

Example 5-1 was prepared such that the artificial hair follicle unit comprises one strand of human hair, Example 5-2 was prepared so that the artificial hair follicle unit included two strands of human hair, and Example 5-3 It was prepared to contain three strands of human hair, and Examples 5-1 to 5-3 used the conditions of Treatment 11 which were found to be best suited to mimic real hair follicles through clinician hair transplant tests.

7 is an image of a hair transplant training artificial hair follicle unit manufactured according to the present embodiment. Referring to FIG. 7, the hair follicle training artificial hair follicle unit (top picture) manufactured according to the present embodiment has a shape that mimics the appearance of actual hair follicles to have a hair follicle having a length of about 5 mm and a thickness of about 200 to 500 μm. It can be seen that it was prepared as.

Example  6: gelatin Preparation of Artificial Hair follicle Units

One end of the human hair cut to about 2 cm was soaked in a gelatin solution at a depth of 5 mm, and then the gelatin solution applied to the human hair end was cured for 30 minutes at room temperature while immersed in an aqueous solution of glutaraldehyde. Hair follicle units were prepared. At this time, the gelatin solution was prepared by mixing the gelatin (Sigma-Aldrich, G2500) and the curing agent glutaraldehyde (GA, Sigma-Aldrich, G5882) as shown in Table 6, the solvent of the gelatin solution and GA aqueous solution As distilled water, tertiary distilled water was used. Finally, the artificial hair follicle unit prepared was soaked in tertiary distilled water.

	Gelatin solution concentration	GA aqueous solution concentration
process	15 wt%	1 wt%
process	15 wt%	2 wt%
process	15 wt%	3 wt%
process	20 wt%	1 wt%
process	20 wt%	2 wt%
process	20 wt%	3 wt%

Example 6-1 was prepared such that the artificial hair follicle unit comprises one strand of human hair, Example 6-2 was prepared such that the artificial hair follicle unit included two hair strands, and Example 6-3 It was prepared to contain three strands of human hair, and Examples 6-1 to 6-3 used the conditions of Treatment 5 which were found to be best suited to mimic real hair follicles through clinician hair transplant tests.

Referring to Figure 7, the hair transplantation training artificial hair follicle unit prepared according to the present embodiment (pictured at the bottom) is a shape that mimics the appearance of the actual hair follicle to have a hair follicle portion of about 5 mm long, about 200 ~ 500 ㎛ thickness It can be seen that it was prepared as.

Experimental Example

Experiment 1: Evaluation of Implantation Sensitivity

In order to simulate the environment most similar to the actual hair transplantation, the implanter used an implanter used in the existing clinic (Oseong electronic planter OAA-2107), and the artificial scalp pads developed together in the laboratory of Examples 4 to 7 were used. The procedure of placing artificial follicular units was directly performed by a clinician. Hair follicle training artificial hair follicle unit prepared in Example was taken out in the third distilled water and stored in the artificial scalp pad without drying. Instead of the artificial scalp pad, a conventionally used pig skin can be used.

Placement sensitivity assessed by the clinician is shown in Table 7 below.

Example	Insertion strength
4-1	○
4-2	○
5-1	◎
5-2	◎
5-3	◎
6-1	○
6-2	○
6-3	○
◎: very similar ○: similar △: (relative) almost similar

Even in the placement test by the clinician, the artificial hair follicle units of Examples 4 to 6 were similar to the actual sensitivity of the hair follicles, and in particular, the artificial hair follicle units of Examples 5-1 to 5-3 showed very similar sensitivity to the actual hair follicles. It was.

In addition to the examples shown in Table 7, artificial hair follicle units to which alginate solutions 1 to 10 and 12 were applied and artificial hair follicle units to which gelatin solutions 1 to 4 and 6 were applied were manufactured and tested by a clinician under the same conditions. The implantation sensitivity of the artificial hair follicle unit to which the alginate solutions 1 to 10 and 12 were applied and the artificial hair follicle unit to which the gelatin solutions 1 to 4 and 6 were applied showed mostly similar or nearly similar to the actual hair follicles.

Experiment 2: Hardness and Elasticity Evaluation

In Experiment 1, hardness and elasticity measurement experiments were performed on the hair follicle training units of Examples 5-1 to 5-3, which were evaluated to have the best insertion sensitivity, based on the KS M 6518: 2006 standard. At this time, the artificial hair follicle unit prepared in Example to implement the same conditions as the actual hair follicle graft managed before the transplantation to maintain the moisture is used to measure the hardness and elasticity without taking out the stored in soaked in distilled water 3rd It became. The experimental results are shown in Table 8 below.

	Hardness	Elasticity
Example 5-1	30.0	20.7%
Example 5-2	29.7	20.1%
Example 5-3	30.3	19.8%
Average	30	20.2%

The hardness and elasticity of Examples 5-1 to 5-3, which exhibited a sensitivity similar to that of actual hair follicles in a clinician's placement test, were approximately 30 and 20.2%, respectively. Although the hardness and elasticity of the actual hair follicles cannot be measured, since the implantation feeling was similar to that of the artificial hair follicle units of Examples 5-1 to 5-3, it is determined that the hardness and elasticity of Table 8 will be similar.

Although the above has been described with reference to embodiments of the present invention, those skilled in the art may variously modify the present invention without departing from the spirit and scope of the present invention as set forth in the claims below. And can be changed.

Claims (22)

1. For preparing an artificial scalp pad, comprising 100 parts by weight of a silicone polymer having a functional group capable of crosslinking reaction with a sock end, or a side chain, or a side chain, or a side chain, 1 to 30 parts by weight of a silica-based filler, and 0.05 to 5 parts by weight of a peroxide. Silicone rubber composition.
2. The method of claim 1,

   The functional group capable of crosslinking with the peroxide is at least one selected from the group consisting of vinyl group, allyl group, (meth) acryloyl group and carboxyl group, silicone rubber composition for artificial scalp pad manufacturing.
3. The method of claim 1,

   The silicone polymer comprises 0.005 to 0.5 mol% of a functional group capable of crosslinking with the peroxide, and is represented by the following Chemical Formula 1, the silicone rubber composition:

   [Formula 1]

   R _a SiO _{(4-a) / 2}

   In Chemical Formula 1,

   R is a functional group which crosslinks with a peroxide, or an aliphatic saturated hydrocarbon group having 1 to 10 carbon atoms, an aliphatic unsaturated hydrocarbon group having 1 to 10 carbon atoms, or an aromatic unsaturated hydrocarbon group having 1 to 30 carbon atoms, and a is 1.90 to 2.05 It is positive.
4. An artificial scalp pad wherein the composition of claim 1 is cured onto a pad.
5. The method of claim 4, wherein

   The artificial scalp pad is characterized in that it is used for hair transplant training, artificial scalp pad.
6. The method of claim 4, wherein

   The artificial scalp pad is characterized in that Shore A hardness of 15 to 45, elongation of 700 to 1000%, artificial scalp pad.
7. Mixing a silicone rubber composition comprising 100 parts by weight of a silicone polymer having a functional group capable of crosslinking reaction with a sock end or a side chain or side chain or side chain, 1 to 30 parts by weight of silica-based filler and 0.05 to 5 parts by weight of peroxide Doing; And

   Forming and curing the mixed silicone rubber composition in the shape of a pad, hair transplant training artificial scalp pad manufacturing method.
8. Human hair or artificial hair, and the hair follicle formed on one end of the human hair or artificial hair, artificial hair follicle training unit for hair transplantation.
9. The method of claim 8,

   The hair follicles will comprise a silicone or hydrogel, hair transplant training artificial hair follicle unit.
10. The method of claim 8,

    The artificial hair follicle unit will comprise at least one human hair or artificial hair, artificial hair follicle training for hair transplant training.
11. A first step of preparing human hair or artificial hair to have a length of 2 cm or more;

    A second step of applying a silicon paste or a hydrogel solution to one end of the human hair or the human hair by immersing one end of the human hair or the human hair in the silicone paste or the hydrogel solution; And

    A third step of forming a hair follicle at one end of the human hair or the human hair by curing the human hair or the human hair coated with the silicone paste or the hydrogel solution

    Including, hair transplantation training artificial hair follicle unit manufacturing method.
12. The method of claim 11,

    The silicon paste is a one-component room temperature curing type of silicone, hair follicle training artificial hair follicle unit manufacturing method.
13. The method of claim 11,

    The hydrogel solution comprises gelatin or alginate, hair transplant training artificial hair follicle unit manufacturing method.
14. The method of claim 11,

    The second step includes immersing one end of the human hair or artificial hair in a depth of 0.1 cm to 1 cm in the silicone paste or hydrogel solution, hair transplant training artificial hair follicle unit manufacturing method.
15. The method of claim 11,

    When the hydrogel solution is applied to one end of the human hair or artificial hair in the second step, the hardening of the third step is performed in an aqueous solution containing a curing agent, a method for manufacturing artificial hair follicle unit for hair transplantation training.
16. The method of claim 11,

    One or more human hair or artificial hair is included in the artificial hair follicle unit, a method for producing a hair follicle training artificial hair follicle unit.
17. An insertion force detection pad on which the scalp pad is seated and outputting a detection signal according to an insertion force applied to the scalp pad;

    A pad stand on which the grip force detection pad is seated and the height, rotation and inclination of at least one axis on which the grip force detection pad is seated are adjusted; And

    The traction force is measured in real time through the detection signal, the measured traction force is controlled to be displayed on at least one monitor, and the releasing force measured for a predetermined period is compared with pre-stored evaluation reference data or expert data. Main controller to display and control so that you can monitor;

    Implantable force measurement and analysis comprising a hair transplant training system.
18. The method of claim 17,

    The pad stand is

    A mounting plate on which the holding force detecting pad is mounted;

    A tilt angle control unit for adjusting the tilt and rotation of the x, y, z axis of the seating plate;

    A height controller configured to adjust the height of the z-axis of the seating plate;

    A switch unit driving the tilt angle control unit and the height control unit to adjust a height, rotation, and inclination of at least one axis of the seating plate; And

    A sub-monitor displaying a result of comparing and analyzing the etch force measured in real time and the etch force measured during the preset period with pre-stored data according to the control of the main controller;

    Implantable force measurement and analysis comprising a hair transplant training system.
19. The method of claim 17,

    The main controller

    A signal input unit converting an analog detection signal input in real time from the insertion force detecting pad into a digital detection signal;

    An etch force analysis unit for measuring and sharing an etch force in real time through the digital detection signal, and comparing and analyzing the etch force measured during a training period or a predetermined period with previously stored evaluation reference data to generate evaluation data; And

    A monitoring controller which controls the grip force measured in real time to be displayed on at least one monitor and controls the evaluation data analyzed by the grip force analyzer to be displayed on the at least one monitor;

    Implantable force measurement and analysis comprising a hair transplant training system.
20. The method of claim 19,

    A sound control unit for controlling an acoustic device to generate a sound corresponding to a holding force measured in real time by the holding force analyzer; And

    A database for storing and sharing the data of the measurement force of the real time, the evaluation reference data, the expert data, the measurement force of the skilled person performed in advance, and the evaluation data;

    Hair transplant training system capable of measuring and analyzing the grip force further comprising.
21. The method of claim 17,

    The main controller

    The evaluation data is generated by comparing and analyzing the holding force data measured during a training period or a predetermined period with the holding force measurement data of the expert data or a previously performed expert.

    A graft measuring and analyzing hair transplant training system that controls the generated evaluation data to be displayed on the at least one monitor.
22. The method of claim 17,

    The main controller

    2D graph, 2D space, 3D graph, 3 so that the measured insertion force can be displayed on the at least one monitor in the form of at least one of 2D graph, 2D space, 3D graph, 3D space Generates the insertion force data in the form of at least one of the dimensional space,

    2D graph, 2 so that the result of comparing the pre-stored data and the holding force data can be displayed on the at least one monitor in the form of at least one of a two-dimensional graph, two-dimensional space, three-dimensional graph, three-dimensional space An implantable measurement and analysis of hair transplantation training system for generating evaluation data in at least one of a dimensional space, a three-dimensional graph, and a three-dimensional space.

Images