WO2017095736A1 - Gélule d'aspirine en tant que substance active unique ou en combinaison avec d'autres substances actives - Google Patents

Gélule d'aspirine en tant que substance active unique ou en combinaison avec d'autres substances actives Download PDF

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Publication number
WO2017095736A1
WO2017095736A1 PCT/US2016/063845 US2016063845W WO2017095736A1 WO 2017095736 A1 WO2017095736 A1 WO 2017095736A1 US 2016063845 W US2016063845 W US 2016063845W WO 2017095736 A1 WO2017095736 A1 WO 2017095736A1
Authority
WO
WIPO (PCT)
Prior art keywords
soft gelatin
gelatin capsule
oil
liquid fill
fill
Prior art date
Application number
PCT/US2016/063845
Other languages
English (en)
Inventor
Humera Ahmad
Jing Lin
Ram GULLAPALLI
Original Assignee
R.P. Scherer Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R.P. Scherer Technologies, Llc filed Critical R.P. Scherer Technologies, Llc
Publication of WO2017095736A1 publication Critical patent/WO2017095736A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid

Definitions

  • Solubilizers may also be amides, such as 2-pyrrolidone, 2-piperidone, F- caprolactam, N-alkylpyrrolidone, N-hydroxyalkylpyrrolidone, N-alkylpiperidone, N- alkylcaprolactam, dimethylacetamide, and polyvinylpyrrolidone; esters, such as ethyl propionate, tributylcitrate, acetyl triethylcitrate, acetyl tributyl citrate, triethylcitrate, ethyl oleate, ethyl caprylate, ethyl butyrate, triacetin, propylene glycol monoacetate, propylene glycol diacetate, ⁇ -caprolactone and isomers thereof, ⁇ -valerolactone and isomers thereof, ⁇ - butyrolactone and isomers thereof.
  • esters such as ethyl prop

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une gélule qui comporte une enveloppe et une charge liquide encapsulée dans celle-ci. La charge liquide comprend au moins une huile, au moins un tensioactif et un agent pharmaceutique sensible à l'humidité et/ou un complément alimentaire sensible à l'humidité dispersé dans l'huile. Une barrière d'humidité peut être incluse entre l'enveloppe et la charge liquide.
PCT/US2016/063845 2015-12-01 2016-11-28 Gélule d'aspirine en tant que substance active unique ou en combinaison avec d'autres substances actives WO2017095736A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562261419P 2015-12-01 2015-12-01
US62/261,419 2015-12-01

Publications (1)

Publication Number Publication Date
WO2017095736A1 true WO2017095736A1 (fr) 2017-06-08

Family

ID=58798036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/063845 WO2017095736A1 (fr) 2015-12-01 2016-11-28 Gélule d'aspirine en tant que substance active unique ou en combinaison avec d'autres substances actives

Country Status (1)

Country Link
WO (1) WO2017095736A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081649A1 (fr) 2018-10-16 2020-04-23 Bayer Healthcare Llc Capsules molles comprenant une matrice de remplissage polymère solide ou de type gel
WO2020094736A1 (fr) 2018-11-07 2020-05-14 Sapir Pharmaceuticals Inc. Solutions lipidiques d'ains
TWI708835B (zh) * 2020-01-17 2020-11-01 和協工程股份有限公司 緩釋型釋碳凝膠基質及土壤整治方法
WO2021011177A1 (fr) * 2019-07-15 2021-01-21 R.P. Scherer Technologies, Llc Capsule de gel mou à inhibiteur de la pompe à protons entérique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001960A1 (fr) * 1999-06-30 2001-01-11 Lipocine, Inc. Compositions pharmaceutiques transparentes contenant de l'huile
US20030199481A1 (en) * 2002-04-08 2003-10-23 Alberto Garavani Pharmaceutical compositions of acetylsalicylic acid and omega-3 oils
US20110171281A1 (en) * 2010-01-14 2011-07-14 Karl Wei Cao Soft capsule composition and method of use
US8524280B2 (en) * 2008-12-15 2013-09-03 Banner Pharmacaps, Inc. Methods for enhancing the release and absorption of water insoluble active agents
US20140242161A1 (en) * 2005-03-11 2014-08-28 Altergon S.A. Soft gelatin capsules

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001960A1 (fr) * 1999-06-30 2001-01-11 Lipocine, Inc. Compositions pharmaceutiques transparentes contenant de l'huile
US20030199481A1 (en) * 2002-04-08 2003-10-23 Alberto Garavani Pharmaceutical compositions of acetylsalicylic acid and omega-3 oils
US20140242161A1 (en) * 2005-03-11 2014-08-28 Altergon S.A. Soft gelatin capsules
US8524280B2 (en) * 2008-12-15 2013-09-03 Banner Pharmacaps, Inc. Methods for enhancing the release and absorption of water insoluble active agents
US20110171281A1 (en) * 2010-01-14 2011-07-14 Karl Wei Cao Soft capsule composition and method of use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081649A1 (fr) 2018-10-16 2020-04-23 Bayer Healthcare Llc Capsules molles comprenant une matrice de remplissage polymère solide ou de type gel
WO2020094736A1 (fr) 2018-11-07 2020-05-14 Sapir Pharmaceuticals Inc. Solutions lipidiques d'ains
WO2021011177A1 (fr) * 2019-07-15 2021-01-21 R.P. Scherer Technologies, Llc Capsule de gel mou à inhibiteur de la pompe à protons entérique
TWI708835B (zh) * 2020-01-17 2020-11-01 和協工程股份有限公司 緩釋型釋碳凝膠基質及土壤整治方法

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