WO2017093266A3 - Method for determining haemostasis under controlled shear rate - Google Patents

Method for determining haemostasis under controlled shear rate Download PDF

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Publication number
WO2017093266A3
WO2017093266A3 PCT/EP2016/079159 EP2016079159W WO2017093266A3 WO 2017093266 A3 WO2017093266 A3 WO 2017093266A3 EP 2016079159 W EP2016079159 W EP 2016079159W WO 2017093266 A3 WO2017093266 A3 WO 2017093266A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
haemostasis
shear rate
cartridge
determining
Prior art date
Application number
PCT/EP2016/079159
Other languages
French (fr)
Other versions
WO2017093266A2 (en
Inventor
Remco VERDOOLD
DE Susanne WITT
Judith COSEMANS
Johan HEEMSKERK
Original Assignee
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Maastricht, Academisch Ziekenhuis Maastricht filed Critical Universiteit Maastricht
Priority to EP16804763.7A priority Critical patent/EP3384275A2/en
Publication of WO2017093266A2 publication Critical patent/WO2017093266A2/en
Publication of WO2017093266A3 publication Critical patent/WO2017093266A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/056—Laminated construction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a method for monitoring of coagulation status and haemostasis in the perioperative setting. According to the method a complex formation is optically measured in a time-lapse manner under flow at physiological shear rate between a mobile binding partner and an immobilized binding partner, and further includes real-time processing and displaying of the processed signal. The invention also relates to an apparatus for applying said method, and to a cartridge applicable in said method, wherein said cartridge is a flow cell (4, 4'). Furthermore, the invention relates to the use of said method, said apparatus and said cartridge for assessing coagulation status or thrombus formation in a whole blood sample. In addition, the invention relates to a kit of parts comprising disposables required for applying said method of the invention with the apparatus of the invention.
PCT/EP2016/079159 2015-12-02 2016-11-29 Method for determining haemostasis under shear WO2017093266A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16804763.7A EP3384275A2 (en) 2015-12-02 2016-11-29 Method for determining haemostasis under shear

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15197417.7 2015-12-02
EP15197417 2015-12-02

Publications (2)

Publication Number Publication Date
WO2017093266A2 WO2017093266A2 (en) 2017-06-08
WO2017093266A3 true WO2017093266A3 (en) 2017-07-13

Family

ID=54782510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/079159 WO2017093266A2 (en) 2015-12-02 2016-11-29 Method for determining haemostasis under shear

Country Status (2)

Country Link
EP (1) EP3384275A2 (en)
WO (1) WO2017093266A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6750443B2 (en) * 2016-10-05 2020-09-02 ソニー株式会社 Platelet aggregation analysis method, platelet aggregation analysis device, platelet aggregation analysis program, and platelet aggregation analysis system
US20240053368A1 (en) * 2020-12-21 2024-02-15 Sedicidodici S.R.L. Method for evaluating blood parameters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137571A2 (en) * 1983-10-13 1985-04-17 Vital Scientific N.V. flow cell
US20110045993A1 (en) * 2008-02-05 2011-02-24 Nigel Kent Microfluidic device for assessing object/test material interactions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211071A1 (en) 2004-12-14 2006-09-21 Millennium Pharmaceuticals, Inc. Device for aggregating, imaging and analyzing thrombi and a method of use
EP2040073A1 (en) 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
WO2010102335A1 (en) 2009-03-10 2010-09-16 Monash University Platelet aggregation using a microfluidics device
WO2015102726A2 (en) 2013-10-16 2015-07-09 President And Fellows Of Harvard College A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137571A2 (en) * 1983-10-13 1985-04-17 Vital Scientific N.V. flow cell
US20110045993A1 (en) * 2008-02-05 2011-02-24 Nigel Kent Microfluidic device for assessing object/test material interactions

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
J J ZWAGINGA ET AL: "Flow-based assays for global assessment of haemostasis. Part 2: Current methods and considerations for the future: Annex Tables", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 January 2006 (2006-01-01), XP055276507, Retrieved from the Internet <URL:https://c.ymcdn.com/sites/www.isth.org/resource/group/d868e44b-42c9-4801-8ab3-c5aa6b3e858a/official_communications/flow-based-assays2_alltables.pdf> [retrieved on 20160531], DOI: 10.1111/j.1538-7836.2006.02178.x *
J J ZWANGINGA ET AL: "Flow-based assays for global assessment of haemostasis. Part 1: Biorheologic considerations - Annex: Figures", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 January 2006 (2006-01-01), XP055276504, Retrieved from the Internet <URL:https://c.ymcdn.com/sites/www.isth.org/resource/group/d868e44b-42c9-4801-8ab3-c5aa6b3e858a/official_communications/flow_based_part1_figures.pdf> [retrieved on 20160531], DOI: 10.1111/J.1538-7836.2006.02177.X *
J. J. ZWAGINGA ET AL: "Flow-based assays for global assessment of hemostasis. Part 1: biorheologic considerations", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 January 2006 (2006-01-01), XP055276502, Retrieved from the Internet <URL:https://c.ymcdn.com/sites/www.isth.org/resource/group/d868e44b-42c9-4801-8ab3-c5aa6b3e858a/official_communications/flow-based-assays_part1.pdf> [retrieved on 20160531], DOI: 10.1111/j.1538-7836.2006.02177.x *
J. J. ZWAGINGA ET AL: "Flow-based assays for global assessment of hemostasis. Part 2: current methods and considerations for the future", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 January 2006 (2006-01-01), XP055276506, Retrieved from the Internet <URL:https://c.ymcdn.com/sites/www.isth.org/resource/group/d868e44b-42c9-4801-8ab3-c5aa6b3e858a/official_communications/flow-based-assays_part2.pdf> [retrieved on 20160531], DOI: 10.1111/j.1538-7836.2006.02178.x *
M. ROEST ET AL: "Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 9, no. 11, 1 November 2011 (2011-11-01), GB, pages 2322 - 2324, XP055300156, ISSN: 1538-7933, DOI: 10.1111/j.1538-7836.2011.04492.x *
SUSANNE M. DE WITT ET AL: "Identification of platelet function defects by multi-parameter assessment of thrombus formation", NATURE COMMUNICATIONS, vol. 5, 16 July 2014 (2014-07-16), pages 1 - 13, XP055276219, DOI: 10.1038/ncomms5257 *
VAN KRUCHTEN R, COSEMANS J M E M, HEEMSKERK J W M: "Measurement of whole blood thrombus formation using parallel-plate flow chambers - a practical guide", PLATELETS, vol. 23, no. 3, May 2012 (2012-05-01), pages 229 - 242, XP009190263, DOI: 10.3109/09537103.2011.630848 *
WESTEIN E, DE WITT S, LAMERS M, COSEMANS J M E M, HEEMSKERK J W M: "Monitoring in vitro thrombus formation with novel microfluidic devices", PLATELETS, vol. 23, no. 7, November 2012 (2012-11-01), pages 501 - 509, XP009190262, DOI: 10.3109/09537104.2012.709653 *

Also Published As

Publication number Publication date
WO2017093266A2 (en) 2017-06-08
EP3384275A2 (en) 2018-10-10

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