WO2017088227A1

WO2017088227A1 - Novel bio-functionalized wound dressing based on fibroin

Info

Publication number: WO2017088227A1
Application number: PCT/CN2015/098557
Authority: WO
Inventors: 张贯京
Original assignee: 深圳市前海康启源科技有限公司
Priority date: 2015-11-28
Filing date: 2015-12-24
Publication date: 2017-06-01
Also published as: CN205163394U

Abstract

A novel bio-functionalized wound dressing based on fibroin. The dressing comprises, in sequence, a cover layer, a medicine layer, a fibroin layer, and an adhesive layer. The medicine layer is provided with a plurality of first protrusions comprising lysozyme. The fibroin layer is provided between the medicine layer and the adhesive layer and is attached to the medicine layer; the area of the fibroin layer is less than that of the medicine layer. The adhesive layer is provided with a plurality of meshes corresponding to the first protrusions and an adhesive strip for adhering to a wound margin, wherein the adhesive strip is provided on the periphery of the surface of the adhesive layer and used for adhering to the skin. A fibroin layer is provided between a medicine layer and an adhesive layer in a dressing, the fibroin layer protects the surface of a wound, and lysozyme of the medicine layer disinfects the wound on the skin, thereby prompting the healing of the wound.

Description

Novel biofunctionalized wound dressing based on silk protein

Technical field

The utility model relates to a wound first aid device, in particular to a novel biological functionalized wound dressing based on silk fibroin.

Background technique

The treatment of large-area wounds is a medical problem, such as large-area burns, large-scale burns, etc. The wounds are not easily wrapped, susceptible to infection, often require skin grafting, and there are problems such as limited skin supply. In large-area wound care, especially in wound care with a large amount of exudate, wound dressings are often used for care. Wound dressings have strong wound exudation treatment ability, and have good absorption and retention of wound exudate. ability. However, when wounds are treated with current wound dressings, wound healing is not effective due to the lack of effective wound protection.

In addition, during the healing process of the wound, especially after the wound dressing continues to cover the wound for a long time, the phenomenon of adhesion wound occurs when the wound dressing is removed or replaced, causing secondary damage of the wound.

Utility model content

The main purpose of the utility model is to provide a novel biological functionalized wound dressing based on silk fibroin, which aims to solve the defects of poor wound healing and secondary damage during wound dressing replacement.

In order to achieve the above object, the present invention provides a novel biologically functionalized wound dressing based on silk fibroin, characterized in that the dressing comprises a cover layer, a drug layer, a silk fibroin layer and an adhesive layer in sequence, wherein:

The drug layer is provided with a plurality of first bumps including lysozyme, the first bumps are disposed on a surface of the drug layer and the silk fibroin layer, and the edge of the drug layer is provided with a paste a strip for pasting with the adhesive layer;

The silk fibroin layer is disposed between the drug layer and the adhesive layer and adheres to the drug layer, and an area of the silk fibroin layer is smaller than an area of the drug layer;

The adhesive layer is provided with a plurality of meshes corresponding to the first bumps and adhesive strips for pasting to the edges of the wound, and the adhesive strips are disposed on the peripheral edges of the surface of the adhesive layer. For sticking to the skin.

Preferably, the first bump is uniformly disposed on a surface of the drug layer that is adhered to the silk fibroin layer.

Preferably, the drug layer is further provided with a plurality of second bumps including an aqueous superabsorbent resin, and the adhesive layer is provided with a plurality of meshes corresponding to the second bumps, the adhesive layer and the drug When the layer is pasted, the second bump is embedded in the mesh, and the silk fibroin layer is in contact with the wound to absorb the exudate of the wound.

Preferably, the first bump and the second bump are circular bumps, diamond bumps, square bumps or rectangular bumps.

Preferably, the mesh is circular, diamond shaped, square or rectangular.

Preferably, the cover layer is a waterproof cotton spunlace fabric layer.

Preferably, the drug layer is gauze or medical plastic.

Preferably, the silk fibroin layer is a silk fibroin film made of silk fibroin.

Preferably, the adhesive layer is gauze or medical plastic.

Preferably, the shape of the dressing is rectangular, square, circular or elliptical.

Compared with the prior art, the novel biological functionalized wound dressing based on silk fibroin adopts the above technical scheme, and achieves the following technical effects: the silk fibroin is disposed between the drug layer and the adhesive layer in the dressing. The layer protects the wound surface through the silk protein layer. At the same time, the wound of the skin is sterilized by the lysozyme of the drug layer to promote the healing of the wound. The four-layer structure design of the dressing reduces the wound on the skin during the dressing change. Secondary damage.

DRAWINGS

1 is a schematic cross-sectional structural view of a preferred embodiment of a novel biologically functionalized wound dressing based on silk fibroin of the present invention;

2 is a schematic plan view showing a preferred embodiment of a drug layer in a novel biologically functionalized wound dressing based on silk fibroin;

3 is a schematic plan view showing a preferred embodiment of an adhesive layer in a novel biologically functionalized wound dressing based on silk fibroin of the present invention;

4 is a schematic cross-sectional structural view showing a combination of a bump and a mesh in a novel biologically functionalized wound dressing based on silk fibroin of the present invention.

The implementation, functional features and advantages of the present invention will be further described with reference to the accompanying drawings.

detailed description

The specific embodiments, structures, features and functions of the present invention are described in detail below with reference to the accompanying drawings and preferred embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

In order to achieve the object of the present invention, the present invention provides a novel biological functionalized wound dressing based on silk fibroin, which is provided by placing a silk protein layer between the drug layer and the adhesive layer in the dressing, and through the silk protein layer to the wound. The wound is protected. At the same time, the wound of the skin is sterilized by the lysozyme of the drug layer to reduce the degree of infection of the skin, and the four-layer structure design of the dressing reduces the secondary damage to the skin wound during dressing change.

As shown in Fig. 1, Fig. 1 is a schematic cross-sectional view showing a preferred embodiment of a novel biologically functionalized wound dressing based on silk fibroin of the present invention. In the present embodiment, the dressing of the dressing 100 includes a cover layer 1, a drug layer 2, a silk fibroin layer 3, and an adhesive layer 4 in this order. The cover layer 1 is adhered to the drug layer 2, and the silk fibroin layer 3 is disposed between the drug layer 2 and the adhesive layer 4.

Wherein, the cover layer 1 can be made of a waterproof cotton spunlace fabric or any other suitable waterproof non-woven gauze, and the cover layer 1 can effectively prevent the external environment from polluting the dressing 100. . The surface of the cover layer 1 and the drug layer 2 is coated with a medical ointment such that the cover layer 1 is adhered to the drug layer 2.

As shown in FIG. 2, FIG. 2 is a schematic plan view showing a preferred embodiment of the drug layer in the novel biologically functionalized wound dressing of the silk fibroin according to the present invention. Referring to FIG. 1 and FIG. 2, in the embodiment, the drug layer 2 is adhered to the silk fibroin layer 3, and the silk fibroin has good water permeability and gas permeability, and has strong adhesion to the wound surface without occupation. The phenomenon of the skin (that is, the growth of the skin at the position where it is not covered) is not penetrated by the bacteria. Therefore, the silk protein can be formed into a film as the silk protein layer 3 and attached to the drug layer 2 to protect the wound surface. The side of the drug layer 2 and the silk fibroin layer 3 are provided with bumps 20 which are uniformly or unevenly distributed. The bumps 20 may be, but are not limited to, circular bumps, diamond bumps, square bumps, rectangular bumps, or other shaped bumps. The bump 20 is a granule comprising lysozyme which is capable of sterilizing a wound. Due to the large number of the bumps 20, in other embodiments, the partial bumps 20 comprise an aqueous superabsorbent resin for absorbing liquid exudates from the wounds of the skin, which facilitates healing of the wounds of the skin. That is, among all the bumps of the drug layer 2, part of the bumps 20 (which may also be referred to as first bumps) include lysozyme, and another portion of the bumps 20 (which may also be referred to as second bumps) include high water content. Water absorbing resin. The drug layer 2 can be gauze or medical plastic. The drug layer 2 is combined with the silk fibroin layer 3, on the one hand, the wound protein layer 3 can be used to protect the wound surface, and on the other hand, the lysozyme in the drug layer 2 can be used to sterilize the wound, which is advantageous for the water-absorbing super absorbent resin to absorb the exudate of the wound. Can promote the healing of wounds.

Further, the area of the silk fibroin layer 3 is smaller than the area of the drug layer 2. An adhesive strip 21 is disposed at an edge of the drug layer 2, and the adhesive strip 21 is adhered to the adhesive layer 4 such that the drug layer 2 and the adhesive layer 4 are pasted together. It should be noted that the drug layer 2 is an adhesive structure that can be peeled off from the adhesive layer 4, that is, the drug layer 2 adhered to the surface of the adhesive layer 4 can be torn off. That is to say, the drug layer 2 and the silk fibroin layer 3 can be replaced, which is beneficial to the healing of the wound of the skin and reduces the secondary damage to the skin wound when the dressing is changed.

As shown in FIG. 3, FIG. 3 is a schematic plan view showing a preferred embodiment of the adhesive layer in the novel biologically functionalized wound dressing of the silk fibroin according to the present invention. As shown in FIG. 4, FIG. 4 is a schematic cross-sectional structural view showing a combination of a bump and a mesh in a novel biologically functionalized wound dressing based on silk fibroin.

Referring to FIG. 2, FIG. 3 and FIG. 4, in the embodiment, the corresponding position of the surface of the adhesive layer 4 and the drug layer 2 is pasted, and includes a plurality of corresponding positions corresponding to the first bump and the second bump. In the mesh 40, the silk fibroin layer 3 is located between the net mouth 40 and the bump 20, which is beneficial to the silk fibroin layer 3 while protecting the wound surface, and the drug layer 2 fully sterilizes the wound. The mesh 40 can be, but is not limited to, a circular, diamond, square, rectangular or other shaped mesh 40. The other side of the adhesive layer 4 includes an adhesive strip 41 which is located at the peripheral edge of the adhesive layer 4, and the adhesive strip 41 is used for sticking to the edge of the wound of the skin.

When the adhesive layer 4 is pasted with the drug layer 2, the bumps 20 are embedded in the mesh 40 (as shown in FIG. 4, the bumps 20 are embedded in the mesh 40) through the silk fibroin layer 3 and The skin is in contact with the wound to protect the wound surface of the skin while sterilizing the wound and/or absorbing the wound exudate. The adhesive layer 4 is gauze or medical plastic, which is light and thin (between 0.01 and 0.1 mm) and soft.

The shape of the dressing 100 may be, but not limited to, rectangular, square, circular or elliptical, and the like.

The above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the patents of the present invention. Any equivalent structure or equivalent function transformation made by the description of the present invention and the contents of the drawings may be directly or indirectly applied to other related The technical fields are all included in the scope of patent protection of the present invention.

Claims

A novel biologically functionalized wound dressing based on silk fibroin, characterized in that the dressing comprises a cover layer, a drug layer, a silk fibroin layer and an adhesive layer, wherein:

The drug layer is provided with a plurality of first bumps including lysozyme, the first bumps are disposed on a surface of the drug layer and the silk fibroin layer, and the edge of the drug layer is provided with a paste a strip for pasting with the adhesive layer;

The silk fibroin layer is disposed between the drug layer and the adhesive layer and adheres to the drug layer, and an area of the silk fibroin layer is smaller than an area of the drug layer;

The adhesive layer is provided with a plurality of meshes corresponding to the first bumps and adhesive strips for pasting to the edges of the wound, and the adhesive strips are disposed on the peripheral edges of the surface of the adhesive layer. For sticking to the skin.
The silk fibroin-based novel biofunctionalized wound dressing according to claim 1, wherein the first bump is uniformly disposed on a surface of the drug layer to which the silk fibroin layer is attached.
The silk fibroin-based novel biofunctionalized wound dressing according to claim 1, wherein the drug layer is further provided with a plurality of second bumps including an aqueous superabsorbent resin, and the adhesive layer is provided with a plurality of a mesh corresponding to the second bump, the second bump is embedded in the mesh when the adhesive layer is pasted with the drug layer, and the wound is contacted by the silk protein layer to absorb the wound Exudate.
The silk fibroin-based novel biofunctionalized wound dressing according to claim 3, wherein the first bump and the second bump are circular bumps, diamond bumps, square bumps or rectangular bumps. .
A novel silk fibroin-based biofunctionalized wound dressing according to claim 1 wherein the mesh is circular, rhombic, square or rectangular.
A novel silk fibroin-based biofunctionalized wound dressing according to claim 1 wherein said cover layer is a waterproof cotton spunlace.
A novel silk fibroin-based biofunctionalized wound dressing according to claim 1 wherein the drug layer is gauze or medical plastic.
The silk fibroin-based novel biofunctionalized wound dressing according to claim 1, wherein the silk fibroin layer is a silk fibroin film produced from silk fibroin.
A novel silk fibroin-based biofunctionalized wound dressing according to claim 1, wherein the adhesive layer is gauze or medical plastic.
A novel silk fibroin-based biofunctionalized wound dressing according to claim 1 which is rectangular, square, circular or elliptical in shape.