WO2017077551A3 - An amorphous nintedanib esylate and solid dispersion thereof - Google Patents
An amorphous nintedanib esylate and solid dispersion thereof Download PDFInfo
- Publication number
- WO2017077551A3 WO2017077551A3 PCT/IN2016/050378 IN2016050378W WO2017077551A3 WO 2017077551 A3 WO2017077551 A3 WO 2017077551A3 IN 2016050378 W IN2016050378 W IN 2016050378W WO 2017077551 A3 WO2017077551 A3 WO 2017077551A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amorphous
- nintedanib
- solid dispersion
- nintedanib esylate
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nintedanib base polymorphic forms and processes for preparing the same. A process for the purification of nintedanib base is disclosed. An amorphous form of nintedanib and process for the preparation of the same are also disclosed. A solid dispersion of amorphous nintedanib with pharmaceutically acceptable excipients and processes for the preparation of the same are also disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN5942/CHE/2015 | 2015-11-03 | ||
IN5942CH2015 | 2015-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017077551A2 WO2017077551A2 (en) | 2017-05-11 |
WO2017077551A3 true WO2017077551A3 (en) | 2017-06-15 |
Family
ID=57838443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2016/050378 WO2017077551A2 (en) | 2015-11-03 | 2016-11-02 | An amorphous nintedanib esylate and solid dispersion thereof |
Country Status (1)
Country | Link |
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WO (1) | WO2017077551A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018165865A1 (en) * | 2017-03-14 | 2018-09-20 | 新源生物科技股份有限公司 | Crystal forms of 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone |
JP2024016309A (en) * | 2020-12-21 | 2024-02-07 | トーアエイヨー株式会社 | solid dispersion |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013099A1 (en) * | 2002-07-24 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition |
WO2009071523A1 (en) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Process for the manufacture of an indolinone derivative |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
PE20091445A1 (en) | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES AND PROCEDURE FOR ITS MANUFACTURE |
-
2016
- 2016-11-02 WO PCT/IN2016/050378 patent/WO2017077551A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013099A1 (en) * | 2002-07-24 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition |
WO2009071523A1 (en) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Process for the manufacture of an indolinone derivative |
Non-Patent Citations (2)
Title |
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ANONYMOUS: "New crystalline forms of methyl-(3Z)-3-[({4-[N-methyl-2-(4-methyl-1-piperazinyl)acetamido]phenyl}-amino)(phenyl)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate (IPCOM000210964D)", IP.COM JOURNAL, 19 September 2011 (2011-09-19), XP002767764 * |
CAIRA: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, vol. 198, 1 January 1998 (1998-01-01), SPRINGER, BERLIN, DE, pages 163 - 208, XP008166276, ISSN: 0340-1022 * |
Also Published As
Publication number | Publication date |
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WO2017077551A2 (en) | 2017-05-11 |
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