WO2017043914A3 - Pharmaceutical composition comprising salicornia spp. as an active ingredient for the prevention or treatment of thrombosis, and health functional food comprising the same - Google Patents

Pharmaceutical composition comprising salicornia spp. as an active ingredient for the prevention or treatment of thrombosis, and health functional food comprising the same Download PDF

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Publication number
WO2017043914A3
WO2017043914A3 PCT/KR2016/010162 KR2016010162W WO2017043914A3 WO 2017043914 A3 WO2017043914 A3 WO 2017043914A3 KR 2016010162 W KR2016010162 W KR 2016010162W WO 2017043914 A3 WO2017043914 A3 WO 2017043914A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
blood
present
thrombosis
prevention
Prior art date
Application number
PCT/KR2016/010162
Other languages
French (fr)
Other versions
WO2017043914A2 (en
Inventor
Deuk Hoi Kim
Ho Yong Sohn
Mee Hyang KWEON
Original Assignee
Phyto Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phyto Corporation filed Critical Phyto Corporation
Publication of WO2017043914A2 publication Critical patent/WO2017043914A2/en
Publication of WO2017043914A3 publication Critical patent/WO2017043914A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a pharmacuetical composition for preventing or treating thrombosis, comprising an extract of Salicornia europaea (Salicornia spp.) containing phenolic acids and flavonols as active ingredients. The composition of the present inventoin: exhibits a strong anti-thrombotic activity through an effect of inhibiting platelet aggregation, which initiates the formation of blood clots, together with the inhibition of blood clot formation-related enzymes and blood coagulation factors; never exhibits a hemolytic activity on human erythrocytes; has an excellent thermal stability; and does not exhibit the loss of a blood coagulation factor inhibitory effect and a blood clot formation-related enzyme inhibitory effect even in acidic conditions of pH 2 and in the plasma, and therefore, the composition of the present invention is expected to be used for the prevention and treatment of thrombosis, such as an ischemic stroke and a hemorrhagic stroke, through the improvement of blood circulation. The composition of the present invention is processed in various forms, such as an extract, a powder, a pill, and a tablet, and can be formulated in the form that allows the composition to be taken at any time.
PCT/KR2016/010162 2015-09-09 2016-09-09 Pharmaceutical composition comprising salicornia spp. as an active ingredient for the prevention or treatment of thrombosis, and health functional food comprising the same WO2017043914A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0127594 2015-09-09
KR1020150127594A KR101691855B1 (en) 2015-09-09 2015-09-09 Pharmaceutical composition comprising the extraction of salicornia spp. as an effective component for prevention or treatment of thrombosis and health functional food comprising the same

Publications (2)

Publication Number Publication Date
WO2017043914A2 WO2017043914A2 (en) 2017-03-16
WO2017043914A3 true WO2017043914A3 (en) 2017-05-18

Family

ID=57797278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/010162 WO2017043914A2 (en) 2015-09-09 2016-09-09 Pharmaceutical composition comprising salicornia spp. as an active ingredient for the prevention or treatment of thrombosis, and health functional food comprising the same

Country Status (2)

Country Link
KR (1) KR101691855B1 (en)
WO (1) WO2017043914A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101938396B1 (en) * 2017-05-15 2019-01-15 주식회사 파이토코퍼레이션 A pharmaceutical composition for the prevention or treatment of dementia and improvement of cognitive function comprising extract of Salicornia europaea
KR102130337B1 (en) 2018-03-29 2020-07-06 경북대학교 산학협력단 Pharmaceutical composition comprising extraction of Rumex acetosa L as an effective components for prevention and treatment of thrombosis
KR102186561B1 (en) 2018-03-29 2020-12-08 경북대학교 산학협력단 Pharmaceutical composition comprising extraction of Astilbe chinensis as an effective components for prevention and treatment of thrombosis
KR102023637B1 (en) * 2019-01-08 2019-09-20 주식회사 파이토코퍼레이션 Food or feed composition for improving cognitive function or memory comprising extract of desalted Salicornia europaea
PT115324B (en) 2019-02-20 2021-11-15 Novadelta Comercio E Ind De Cafes Lda PRODUCTION PROCESS OF EDIBLE SUBSTANCE BASED ON HALOPHYTE PLANTS, USE AND SYSTEM OF RESPECTIVE EDIBLE PRODUCTS
KR20230146861A (en) * 2022-04-13 2023-10-20 전남대학교산학협력단 Composition for preventing, treating or improving bone disease, comprising Salicornia europaea extract or a fraction thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787328A (en) * 2010-03-16 2010-07-28 汕头大学 Extraction method of Salicorne seed oil
KR20110081007A (en) * 2010-01-05 2011-07-13 목포대학교산학협력단 Composition for preventing or improving hypertension containing fermented salicornia herbacea
KR20110093016A (en) * 2010-02-11 2011-08-18 목포대학교산학협력단 Composition for preventing or improving diabetes containing fermented salicornia herbacea and the use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110081007A (en) * 2010-01-05 2011-07-13 목포대학교산학협력단 Composition for preventing or improving hypertension containing fermented salicornia herbacea
KR20110093016A (en) * 2010-02-11 2011-08-18 목포대학교산학협력단 Composition for preventing or improving diabetes containing fermented salicornia herbacea and the use thereof
CN101787328A (en) * 2010-03-16 2010-07-28 汕头大学 Extraction method of Salicorne seed oil

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ESSAIDI, I. ET AL.: "Phytochemical investigation of Tunisian Salicornia herbacea L., antioxidant, antimicrobial and cytochrome P450 (CYPs) inhibitory activities of its methanol extract", FOOD CONTROL, vol. 32, no. 1, 2013, pages 125 - 133, XP055381496 *
JANG, H. S. ET AL.: "Antioxidant and antithrombus activities of enzyme-treated Salicornia herbacea extracts", ANNALS NUTRITION AND METABOLISM, vol. 51, no. 2, 2007, pages 119 - 125, XP008147591 *

Also Published As

Publication number Publication date
KR101691855B1 (en) 2017-01-03
WO2017043914A2 (en) 2017-03-16

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