WO2016207824A3 - Composition pharmaceutique stable comprenant du ramipril et/ou de l'amlodipine - Google Patents

Composition pharmaceutique stable comprenant du ramipril et/ou de l'amlodipine Download PDF

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Publication number
WO2016207824A3
WO2016207824A3 PCT/IB2016/053738 IB2016053738W WO2016207824A3 WO 2016207824 A3 WO2016207824 A3 WO 2016207824A3 IB 2016053738 W IB2016053738 W IB 2016053738W WO 2016207824 A3 WO2016207824 A3 WO 2016207824A3
Authority
WO
WIPO (PCT)
Prior art keywords
ramipril
amlodipine
pharmaceutical composition
stable pharmaceutical
relates
Prior art date
Application number
PCT/IB2016/053738
Other languages
English (en)
Other versions
WO2016207824A2 (fr
Inventor
Rajeev Singh Raghuvanshi
Anup Avijit Choudhury
Muzammil Tariq
Ashok Kumar SIVAPRAKASAM
Original Assignee
Dr. Reddy's Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd filed Critical Dr. Reddy's Laboratories Ltd
Publication of WO2016207824A2 publication Critical patent/WO2016207824A2/fr
Publication of WO2016207824A3 publication Critical patent/WO2016207824A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition pharmaceutique stable comprenant une combinaison à dose fixe d'amlodipine et de ramipril, et un excipient pharmaceutiquement acceptable. En outre, la présente invention concerne un procédé de préparation desdites compositions et un procédé d'utilisation de celle-ci dans le traitement de troubles cardiovasculaires.
PCT/IB2016/053738 2015-06-23 2016-06-23 Composition pharmaceutique stable comprenant du ramipril et/ou de l'amlodipine WO2016207824A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3159CH2015 2015-06-23
IN3159/CHE/2015 2015-06-23

Publications (2)

Publication Number Publication Date
WO2016207824A2 WO2016207824A2 (fr) 2016-12-29
WO2016207824A3 true WO2016207824A3 (fr) 2017-02-09

Family

ID=57584779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/053738 WO2016207824A2 (fr) 2015-06-23 2016-06-23 Composition pharmaceutique stable comprenant du ramipril et/ou de l'amlodipine

Country Status (1)

Country Link
WO (1) WO2016207824A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011104588A2 (fr) * 2010-02-24 2011-09-01 Sanofi-Aventis Deutschland Gmbh Formulations pharmaceutiques solides de ramipril et de bésylate d'amlodipine et leur préparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011104588A2 (fr) * 2010-02-24 2011-09-01 Sanofi-Aventis Deutschland Gmbh Formulations pharmaceutiques solides de ramipril et de bésylate d'amlodipine et leur préparation

Also Published As

Publication number Publication date
WO2016207824A2 (fr) 2016-12-29

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