WO2016191695A3 - Traitements d'infections intracellulaires strictes - Google Patents

Traitements d'infections intracellulaires strictes Download PDF

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Publication number
WO2016191695A3
WO2016191695A3 PCT/US2016/034686 US2016034686W WO2016191695A3 WO 2016191695 A3 WO2016191695 A3 WO 2016191695A3 US 2016034686 W US2016034686 W US 2016034686W WO 2016191695 A3 WO2016191695 A3 WO 2016191695A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatments
intracellular infections
obligately intracellular
infections
obligately
Prior art date
Application number
PCT/US2016/034686
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English (en)
Other versions
WO2016191695A2 (fr
Inventor
Jere W. Mcbride
Tian Luo
Taslima T. LINA
Paige S. DUNPHY
Original Assignee
Research Development Foundation
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Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Publication of WO2016191695A2 publication Critical patent/WO2016191695A2/fr
Publication of WO2016191695A3 publication Critical patent/WO2016191695A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions et des procédés utilisés pour le traitement d'infections bactériennes, par exemple d'infections par bactéries intracellulaires strictes. Selon certains modes de réalisation, un inhibiteur de Wnt peut être administré à un sujet mammifère pour traiter l'ehrlichiose
PCT/US2016/034686 2015-05-28 2016-05-27 Traitements d'infections intracellulaires strictes WO2016191695A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562167669P 2015-05-28 2015-05-28
US62/167,669 2015-05-28

Publications (2)

Publication Number Publication Date
WO2016191695A2 WO2016191695A2 (fr) 2016-12-01
WO2016191695A3 true WO2016191695A3 (fr) 2017-01-05

Family

ID=56133065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/034686 WO2016191695A2 (fr) 2015-05-28 2016-05-27 Traitements d'infections intracellulaires strictes

Country Status (1)

Country Link
WO (1) WO2016191695A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019126739A1 (fr) 2017-12-21 2019-06-27 Shepherd Therapeutics, Inc. Thérapies anti-cancer à base de pamoate de pyrvinium
US20220117920A1 (en) * 2019-02-14 2022-04-21 University Of Kentucky Research Foundation N-Aryl Benzenesulfonamides as Protonophores for the Treatment of Cancers, Metabolic Diseases and Traumatic Brain Injury
CN112933066B (zh) * 2021-02-26 2023-05-02 河南省农业科学院 抑制剂kn-93抑制猪繁殖与呼吸综合征病毒体外感染的方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323284A1 (en) * 2012-06-05 2013-12-05 Jazzya Investments USE OF mTOR INHIBITORS TO TREAT BACTERIAL INFECTION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323284A1 (en) * 2012-06-05 2013-12-05 Jazzya Investments USE OF mTOR INHIBITORS TO TREAT BACTERIAL INFECTION

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BAI XIYUAN ET AL: "Inhibition of Nuclear Factor-Kappa B Activation Decreases Survival of Mycobacterium tuberculosis in Human Macrophages", PLOS ONE, vol. 8, no. 4, April 2013 (2013-04-01), XP055293629 *
DE GROOTE M A ET AL: "The Search For New Antimicrobial Agents Against Mycobacterium abscessus", ABSTRACTS OF THE INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, 2012, & 52ND INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (ICAAC); SAN FRANCISCO, CA, USA; SEPTEMBER 09 -12, 2012, pages F831, XP009191237, ISSN: 0733-6373 *
DUMLER J STEPHEN ET AL: "Ehrlichioses in humans: Epidemiology, clinical presentation, diagnosis, and treatment", CLINICAL INFECTIOUS DISEASES, THE UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, US, vol. 45, no. Suppl. 1, 15 July 2007 (2007-07-15), pages S45 - S51, XP002498681, ISSN: 1058-4838, DOI: 10.1086/518146 *
FLORES R ET AL: "Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Caprin 2 Enhancing the Canonical Wnt Signaling Pathway", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 110, 2010, & 110TH GENERAL MEETING OF THE AMERICAN-SOCIETY-FOR-MICROBIOLOGY; SAN DIEGO, CA, USA; MAY 23 -27, 2010, pages B - 055, XP055293653, ISSN: 1060-2011 *
KESSLER MIRJANA ET AL: "Chlamydia trachomatis Disturbs Epithelial Tissue Homeostasis in Fallopian Tubes via Paracrine Wnt Signaling", AMERICAN JOURNAL OF PATHOLOGY, vol. 180, no. 1, January 2012 (2012-01-01), pages 186 - 198, XP055293648 *
LUO TIAN ET AL: "Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival", INFECTION AND IMMUNITY, vol. 84, no. 3, March 2016 (2016-03-01), pages 686 - 700, XP009191238 *
SENDIDE KHALID ET AL: "Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1", JOURNAL OF IMMUNOLOGY, vol. 174, no. 7, April 2005 (2005-04-01), pages 4210 - 4219, XP055293620, ISSN: 0022-1767 *
WAKEEL A ET AL: "New insights into molecular Ehrlichia chaffeensis-host interactions", MICROBES AND INFECTION, ELSEVIER, PARIS, FR, vol. 12, no. 5, 1 May 2010 (2010-05-01), pages 337 - 345, XP027011818, ISSN: 1286-4579, [retrieved on 20100129] *

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Publication number Publication date
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