WO2016189552A3 - Novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives - Google Patents

Novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives Download PDF

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Publication number
WO2016189552A3
WO2016189552A3 PCT/IN2016/050156 IN2016050156W WO2016189552A3 WO 2016189552 A3 WO2016189552 A3 WO 2016189552A3 IN 2016050156 W IN2016050156 W IN 2016050156W WO 2016189552 A3 WO2016189552 A3 WO 2016189552A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminopropyl
recycling process
indoline derivatives
formula
novel recovery
Prior art date
Application number
PCT/IN2016/050156
Other languages
French (fr)
Other versions
WO2016189552A2 (en
Inventor
Buchi Reddy Reguri
Kishor Ramdas MORE
Leena GUPTA
Prashant Bhaskarrao PATIL
Tatyaba BHOR
Bharat Bhagvan KASHID
Pramila RAYUDU
Kishor Dinkar WANI
Suhas Maruti PAWAR
Original Assignee
Ipca Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Laboratories Limited filed Critical Ipca Laboratories Limited
Publication of WO2016189552A2 publication Critical patent/WO2016189552A2/en
Publication of WO2016189552A3 publication Critical patent/WO2016189552A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention discloses a novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives, useful intermediates, particularly, for preparation of Silodosin or salts thereof. The present invention also provides novel compounds of Formula-II Formula-III, Formula-IV and Formula-V.
PCT/IN2016/050156 2015-05-26 2016-05-26 Novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives WO2016189552A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2047MU2015 2015-05-26
IN2047/MUM/2015 2015-05-26

Publications (2)

Publication Number Publication Date
WO2016189552A2 WO2016189552A2 (en) 2016-12-01
WO2016189552A3 true WO2016189552A3 (en) 2017-02-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/050156 WO2016189552A2 (en) 2015-05-26 2016-05-26 Novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives

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WO (1) WO2016189552A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2607639B1 (en) 2015-09-30 2018-02-28 Urquima, S.A Maleic acid salt of a silodosin intermediate
CN106928118B (en) * 2017-04-11 2022-08-23 常州瑞明药业有限公司 Method for preparing silodosin intermediate
KR102365411B1 (en) * 2017-08-08 2022-02-21 (주)헥사파마텍 Novel sulfonamide intermediates and processes for preparing silodosin using the same
CN108640870A (en) * 2018-04-12 2018-10-12 常州大学 A method of synthesis 6- bromomethyl -3- methoxyl group -2- nitropyridines
CN108929259A (en) * 2018-08-29 2018-12-04 四川青木制药有限公司 A method of preparing Silodosin intermediate
CN114478202A (en) * 2022-02-16 2022-05-13 江苏飞宇医药科技股份有限公司 Method for continuously preparing 2- (2,2, 2-trifluoroethoxy) phenol

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013056842A1 (en) * 2011-10-21 2013-04-25 Sandoz Ag Method for preparing silodosin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013056842A1 (en) * 2011-10-21 2013-04-25 Sandoz Ag Method for preparing silodosin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANNE FIKSDAHL ET AL.: "The Synthesis of (S)-1-Methyl-3-phenylpropylamine by Inversion of Amines", ACTA CHEMICA SCANDINAVIA, vol. 47, 1993, pages 1050 - 1052, XP055362087 *
SAID, SADRI A.: "Stereoselective transformations of chiral amines", DISS. NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY, 2002, XP055362084, ISSN: 0809103X *

Also Published As

Publication number Publication date
WO2016189552A2 (en) 2016-12-01

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