WO2016181748A1

WO2016181748A1 - Powder dissolving device and dissolving method

Info

Publication number: WO2016181748A1
Application number: PCT/JP2016/061959
Authority: WO
Inventors: 俊成高橋; 善之園田; 弘樹松原; 和人濱野; 敏司原田
Original assignee: ニプロ株式会社
Priority date: 2015-05-11
Filing date: 2016-04-14
Publication date: 2016-11-17
Also published as: JP6881300B2; CL2017002842A1; JPWO2016181748A1; CO2017011914A2; MX2017014427A

Abstract

The purpose of the present invention is to provide a powder dissolving device and dissolving method that suppress the arising of undissolved powder at the bottom of a dissolution tank, thereby preventing powdered agents from remaining undissolved. This powder dissolving device 1 is provided with a dissolution tank 2 for storing a dissolving solution L, stirring blades 3 provided in the dissolution tank 2, a connecting pipe 4 linking to the dissolution tank 2 at at least two locations of different heights, and a pump P provided in the connecting pipe 4, and is characterized in that the stirring blades 3 are disposed in a position that is a prescribed spacing distance from the bottom 2b of the dissolution tank 2, and the dissolution tank 2 and the connecting pipe 4 are connected such that the dissolving solution L in the dissolution tank 2 is sent to the bottom 2b side of the dissolution tank 2 through the connecting pipe 4 by driving the pump P and the flow of the dissolving solution L discharged into the dissolution tank 2 from the connecting pipe 4 flows along the bottom 2b of the dissolution tank 2.

Description

Powder melting apparatus and melting method

The present invention relates to a powder melting apparatus and a melting method.

There is known a dissolving device for stirring and dissolving a liquid such as water and a powdered drug such as dialysate used for hemodialysis. Such a dissolution apparatus has a dissolution tank into which water or a powder drug is charged, and a stirring blade for stirring the solution in the dissolution tank, dissolves the powder drug in the dissolution tank, Prepare the lysate. As a stirring blade used when preparing such a solution, for example, a stirring blade described in Patent Document 1 is used. In the stirring blade of Patent Document 1, a stirring blade is attached from the upper part of the dissolution tank, and the liquid in the dissolution tank is forcibly stirred by a motor.

Japanese Utility Model Publication No. 6-28119

However, when a stirring blade as in Patent Document 1 is used, undissolved powder may collect in the center of the bottom of the dissolution tank, and undissolved powder may remain below the stirring blade. It is difficult to dissolve. Therefore, there is a possibility that the solution does not have a predetermined concentration.

Therefore, in view of such problems, the present invention aims to provide a powder dissolution apparatus and a dissolution method that prevent undissolved powder from remaining at the bottom of the dissolution tank and prevent undissolved powder drug from remaining undissolved.

The powder dissolving apparatus of the present invention includes a dissolving tank for storing a dissolving liquid, a stirring blade provided in the dissolving tank, and a communication pipe communicating between at least two places having different heights among the dissolving tanks. And a pump provided in the communication pipe, wherein the stirring blade is disposed at a position spaced a predetermined distance from the bottom of the dissolution tank, and the solution in the dissolution tank is driven by the pump. The dissolution tank, the communication pipe, and the like so that the flow of the dissolution liquid that is sent to the bottom of the dissolution tank through the pipe and discharged from the communication pipe to the dissolution tank flows along the bottom of the dissolution tank. Are connected.

Further, it is preferable that a bottom portion of the dissolution tank is formed in an inverted conical shape, and the communication pipe is connected to a top portion or a vicinity of the top portion of the inverted cone-shaped bottom portion in the bottom portion of the dissolution tank.

In addition, the rotating shaft of the stirring blade is arranged so as to be shifted from the central axis of the dissolution tank toward the side of the dissolution tank, and passes through the communication pipe to the bottom of the dissolution tank. It is preferable that the flow is configured to be directed toward the stirring blade.

The powder dissolving apparatus further includes a drive unit that rotates the stirring blade forward and backward, and a control unit that controls the drive unit, wherein the control unit is configured to perform the stirring operation. It is preferable that the stirring blade is controlled to rotate so that the dissolved solution stirred by the stirring blade generates an upward flow for a predetermined time after the start.

Further, it is preferable that the control unit controls the pump so that the pump is driven while the upward flow is generated.

The control unit controls the stirring blade so that the solution stirred by the stirring blade generates a downward flow before the dissolving solution causes the upward flow by the stirring blade. The pump is preferably maintained in a non-driven state while the downflow is occurring.

Further, it is preferable that the rotation speed of the stirring blade is changed according to the set liquid amount of the solution.

Further, when the set liquid amount of the dissolution liquid is smaller than a predetermined amount, the driving unit drives the stirring blade at the first rotational speed while the upward flow is generated, and then performs the second rotation. It is preferable that the control unit controls the stirring blade so that the stirring blade is driven by a number, and the first rotational speed is limited to a predetermined rotational speed for suppressing foaming of the solution.

The dissolution method of the present invention includes a dissolution tank for storing a dissolution liquid, a stirring blade provided in the dissolution tank, and a communication pipe communicating between at least two places having different heights among the dissolution tanks, And a pump provided in the communication pipe, wherein the stirring blade is disposed at a position spaced apart from the bottom of the dissolution tank by a predetermined distance. A supply step of supplying a liquid and powdered drug to the dissolution tank; and a dissolution process of stirring the liquid and powdered drug to prepare a solution. In the dissolution process, the pump is driven to The dissolution liquid in the dissolution tank is sent to the bottom of the dissolution tank through the communication pipe, and the flow of the dissolution liquid discharged from the communication pipe to the dissolution tank flows along the bottom of the dissolution tank. It is characterized by.

Further, in the melting method, the bottom of the melting tank is formed in an inverted cone shape, and the communication pipe is connected to the top of the inverted cone-shaped bottom or in the vicinity of the top at the bottom of the melting tank. preferable.

Further, in the melting method, the rotating shaft of the stirring blade is arranged so as to be shifted from the central axis of the dissolving tank toward the side of the dissolving tank, and is sent toward the bottom of the dissolving tank through the communication pipe. It is preferable that the flow of the dissolved solution is directed to the stirring blade.

Further, in the melting step, in the melting step, the stirring blades are arranged so that the dissolved liquid stirred by the stirring blades generates an upward flow for a predetermined time after the stirring blades start stirring operation. It is preferably rotated.

Further, in the above dissolution method, it is preferable that the pump is driven while the upward flow is generated.

Further, the dissolution method may be configured such that the stirring blade rotates so that the solution stirred by the stirring blade generates a downward flow before the dissolving solution generates the upward flow by the stirring blade, and the downward flow is performed. Preferably, the pump is maintained in a non-driven state while

Further, in the above dissolution method, it is preferable that the rotation speed of the stirring blade is changed according to the set liquid amount of the dissolution liquid.

Further, in the dissolution method, when the set liquid amount of the dissolution liquid is smaller than a predetermined amount, the agitating blade is driven at the first rotational speed while the drive unit is generating the upward flow. After that, it is preferable that the stirring blade is driven at a second rotational speed, and the first rotational speed is limited to a predetermined rotational speed for suppressing foaming of the solution.

According to the powder dissolving apparatus and the dissolving method of the present invention, it is possible to suppress the undissolved powder from being generated at the bottom of the dissolving tank and to prevent undissolved powder drug from remaining undissolved.

It is the schematic which shows the powder dissolving apparatus of one Embodiment of this invention. It is a figure which shows an example of the operation panel used for the powder melt | dissolution apparatus of one Embodiment of this invention. It is the schematic which shows the flow of the solution in the bottom part of the powder dissolving apparatus of one Embodiment of this invention. It is a flowchart which shows the melt | dissolution method of one Embodiment of this invention. It is the schematic which shows the state which the 1st communicating path and 2nd communicating path of the communicating pipe were connected. It is the schematic which shows the state from the bottom part of the powder dissolving apparatus to the liquid feeding path. It is the schematic which shows the loop-form circulation path which circulates a solution at the time of interruption of liquid feeding. It is a flowchart explaining the detail of a melt | dissolution process. It is a flowchart explaining the control according to the setting liquid amount of a powder dissolution apparatus.

Hereinafter, the powder dissolution apparatus and the dissolution method of the present invention will be described with reference to the accompanying drawings. The powder dissolution apparatus and the dissolution method of the present invention are used to dissolve a powdered drug in a liquid such as water, such as a powdered dialysis drug for preparing a dialysate used for hemodialysis. In the embodiment described below, a case where a powdered dialysis drug is dissolved in water will be described. However, the present invention is not limited to the case where the dialysis drug is dissolved, but may be applied to the case of preparing another solution. Can do.

FIG. 1 is a schematic view showing an embodiment of the powder dissolving apparatus of the present invention.

As shown in FIG. 1, a powder dissolving apparatus 1 according to an embodiment includes a dissolving tank 2 for storing a dissolving liquid L, a stirring blade 3 provided in the dissolving tank 2, and a height of the dissolving tank 2. The communication pipe 4 communicated between at least two different locations, and the pump P provided in the communication pipe 4.

The dissolution tank 2 is a tank in which a liquid such as water introduced into the dissolution tank 2 and a powdered drug such as a dialysis drug are stirred and dissolved therein. In this embodiment, the dissolution tank 2 is a vertical dissolution tank having a substantially cylindrical side portion 2a extending in a substantially vertical direction and a bottom portion 2b below the side portion 2a. In the present embodiment, the bottom 2b of the dissolution tank 2 is formed in an inverted conical shape as shown in FIG. However, the shape of the bottom 2b of the dissolution tank 2 is not limited to the shape illustrated. For example, the bottom 2b may be flat or may be inclined in one direction.

In the upper part of the dissolution tank 2, a drug inlet 2 c for introducing the dialysis drug into the dissolution tank 2, a supply port 2 d for supplying liquid such as water (RO water) into the dissolution tank 2, and supply Supply means 21 for supplying water to the mouth 2d is provided. In the present embodiment, the supply means 21 includes a water supply port 21a connected to an external pipe or the like. The water supplied from the water supply port 21 a is supplied into the dissolution tank 2 through the supply pipe 21 b of the supply means 21. Between the water supply port 21a and the supply port 2d, there are provided a flow rate sensor 21c that measures the amount of supplied water and a water supply valve 21d that is automatically controlled and opens and closes the pipeline of the supply tube 21b. Further, the upper part of the dissolution tank 2 is connected to a drive unit M such as a motor for rotating the stirring blade 3, a control unit C for controlling various components of the powder dissolving apparatus 1 such as the drive unit M, and the control unit C. In addition, an operation means 5 (not shown in FIG. 1; see FIG. 2) such as an operation panel capable of inputting settings of the powder dissolving apparatus 1 such as an operation mode of the powder dissolving apparatus 1 is provided.

The control unit C is connected to the control unit C so as to be controllable in order to control the drive unit M, the supply unit 21, the pump P, and the like, and controls the connected control target. The control unit C can be, for example, a microprocessor including a calculation unit and a storage unit. The control unit C performs control such that each process described later is executed based on the information input by the operation unit 5.

An operation means such as an operation panel (hereinafter referred to as an operation panel) 5 connected to the control unit C is operated when various processes such as a melting process of the powder dissolving apparatus 1 are performed. The operation panel 5 can be a known operation means such as an operation button or a touch panel. The operation panel 5 includes, for example, a melting mode (“MIXING” in FIG. 2), a washing mode (water washing mode, “RINSE” in FIG. 2), A mode selection unit 52 for selecting a plurality of modes such as a disinfection mode (“CLEANING” in FIG. 2), a liquid amount setting unit 53 for setting a liquid amount, a water supply switch 54a, a stirring switch 54b, a circulation switch 54c, An operation start unit 54 that is operated to start an operation of each process described later, such as a liquid feed switch 54d. Further, by operating the operation panel 5, it is possible to change settings such as the processing time of each process and the amount of set liquid. Note that the operation panel 5 shown in FIG. 2 is merely an example, and the design and arrangement of the operation panel 5 and the display method of each part are not particularly limited.

Further, the powder dissolving apparatus 1 can set the amount of the solution L prepared as described above. The dissolution tank 2 may be provided with a liquid amount detection sensor (not shown) that detects that the set liquid amount has entered the dissolution tank 2. As the liquid amount detection sensor, for example, a float sensor can be used. For example, a plurality of liquid amount detection sensors may be provided in the dissolution tank 2 in order to detect the liquid level in two stages or three or more stages.

As shown in FIG. 1, the communication pipe 4 includes an upper side connection part 41 a provided on the side part 2 a of the dissolution tank 2 and a lower side connection part provided on the bottom part 2 b of the dissolution tank 2. 41b is connected to the dissolution tank 2. In this embodiment, the communication pipe 4 is connected at two locations, the side 2a and the bottom 2b of the dissolution tank 2. However, the communication pipe 4 may be connected to the dissolution tank 2 at at least two places, and may be connected at three or more places. As shown in FIG. 1, the communication pipe 4 is provided with a pump P. By the driving of the pump P, the dissolution liquid L in the dissolution tank 2 is circulated from below the side part 2a of the dissolution tank 2 to the bottom part 2b side of the dissolution tank 2. As shown in FIG. 1, the communication pipe 4 includes a first communication path 42 (communication path formed by

reference numerals

42 a and 42 b in FIG. 1) extending from the upper side connection portion 41 a to the pump P, and the pump P. And a second communication path 43 (communication path formed by

reference numerals

43a, 43b, 43c, 43d and 43e in FIG. 1) extending to the lower side connection portion 41b. The first communication passage 42 has a first valve V1 between the upper side connection portion 41a and the pump P, and has a second valve V2 between the pump P and the lower side connection portion 41b. is doing. The first valve V1 and the second valve V2 are formed by a circulation passage 44 (

reference numerals

44 and 43c) provided as a passage different from the passage (42b, 43a, 43b) in which the pump P is provided. Connected by a passage). In the present embodiment, the structures of the first valve V1 and the second valve V2 are not particularly limited as long as the flow paths described in the present specification can be switched. A three-way valve is used as the second valve V1 and the second valve V2. In the following description, the first valve V1 and the second valve V2 are referred to as a first three-way valve V1 and a second three-way valve V2, respectively.

In the present embodiment, the second three-way valve V2 has a liquid supply path 45 that branches from the second communication path 43 and supplies the liquid to the outside. The liquid feed path 45 is provided with a filter (not shown) that removes impurities from the solution L. After the impurities are removed by the filter, the solution L prepared in the dissolution tank 2 is sent to another container or a dialysis machine through the solution feed path 45. Further, as shown in FIG. 1, the second communication passage 43 has a waste liquid passage 46 (

reference numerals

43e, 46a and 46b) on the downstream side (downstream in the circulation direction of the communication pipe 4) of the second three-way valve V2. Formed passages) are connected. The waste liquid passage 46 branches off from the second communication passage 43 (a connection point between 43d and 43e) between the second three-way valve V2 and the lower side connection portion 41b. The waste liquid path 46 is provided for discharging water or the dissolved liquid L from the dissolution tank 2 when the dissolution tank 2 is washed, for example. As shown in FIG. 1, the waste liquid path 46 is provided with a waste liquid valve V3 and a check valve V4. The waste liquid is discharged by opening the waste liquid valve V3 at the time of waste liquid. Prevents backflow to Further, in the present embodiment, as shown in FIG. 1, an overflow pipe 47 that extends from the upper side to the lower side of the dissolution tank 2 and is connected to the waste liquid path 46 is provided. The overflow pipe 47 is configured such that the dissolution liquid L is discharged from the overflow pipe 47 when the dissolution liquid L exceeds a predetermined amount. In the present embodiment, a part of the solution L is collected when branching between the pump P and the second three-way valve V2 to check whether the solution L is not dissolved, for example. For this purpose, it has a liquid collection path 48 through which the solution L can be discharged. A liquid collection valve V5 is provided in the liquid collection path 48, and the liquid collection valve V5 is opened at the time of liquid collection to enable liquid collection.

The driving unit M drives and rotates the stirring blade 3. In the present embodiment, the drive unit M is a drive motor that can rotate in the forward and reverse directions, and is controlled by the control unit C according to the selected mode and the set liquid amount to rotate the stirring blade 3 forward or backward. . A drive shaft 31 extends downward from the drive unit M toward the inside of the dissolution tank 2. A stirring blade 3 is attached to the distal end side of the drive shaft 31. The drive shaft 31 is provided in such a length that the stirring blade 3 is positioned at a position lower than the liquid level of the solution L at the lowest set liquid amount. The drive shaft 31 may have a fixed length, or the drive shaft 31 can be expanded and contracted, and the drive shaft 31 is driven to expand and contract so that the stirring blade 3 is made of the solution L. You may comprise so that it may move to a position lower than a liquid level.

The stirring blade 3 stirs the powdered medicine by the rotation of the stirring blade 3. As shown in FIG. 1, the stirring blade 3 is disposed at a position spaced apart from the bottom 2 b of the dissolution tank 2 by a predetermined distance. The predetermined distance here is not particularly limited as long as there is a space in which the solution L convects below the stirring blade 3, but for example, the lower end of the stirring blade 3 is located at the lowest position of the bottom 2b of the dissolution tank 2. It is preferable that the dissolution tank 2 is separated by 10 to 30% of the height in the vertical direction. Further, in the present embodiment, as shown in FIG. 1, when the pump P is driven, the dissolution liquid L in the dissolution tank 2 is sent to the bottom 2b side of the dissolution tank 2 through the communication pipe 4. The dissolution tank 2 and the communication pipe 4 are connected so that the flow of the dissolution liquid L discharged from the dissolution tank 2 to the dissolution tank 2 flows along the bottom 2 b of the dissolution tank 2. As a result, as shown by the broken line in FIG. 3, even when the powdery medicine is deposited on the bottom 2b, the medicine is wound up by the flow toward the bottom 2b discharged from the communication tube 4, and is wound up. The obtained powdery medicine is stirred by the stirring blade 3 disposed at a position separated from the bottom 2b, and becomes more easily dissolved. Thereby, it becomes possible to suppress the undissolved residue of the powdery medicine in the solution L.

Further, in the present embodiment, as shown in FIG. 3, the bottom 2 b of the dissolution tank 2 is formed in an inverted conical shape, and the communication pipe 4 is the top of the inverted conical bottom 2 b in the bottom 2 b of the dissolution tank 2. It is connected in the vicinity of T or the top T. With this configuration, the powdery medicine remaining undissolved in the dissolution tank 2 moves downward along both inclined portions S of the bottom portion 2b and is collected in the vicinity of the top portion T of the bottom portion 2b. In the present embodiment, the collected medicine is wound up by the flow of the dissolution liquid L discharged into the dissolution tank 2 from the communication pipe 4 extending in the horizontal direction. The flow of the dissolution liquid L flows along the inclined portion S of the bottom portion 2 b, and the medicine flows upward from the bottom portion 2 b in the dissolution tank 2 and moves closer to the stirring blade 3. Thereby, the wound-up chemical | medical agent is stirred by the stirring blade 3, agitation efficiency improves, and it can suppress a melt | dissolution residue more. Moreover, in this embodiment, as FIG.1 and FIG.3 shows, the rotating shaft (drive shaft 31) of the stirring blade 3 slip | deviates from the center axis | shaft X of the dissolution tank 2 toward the side part 2a of the dissolution tank 2. FIG. The flow of the dissolving liquid L which is disposed and is sent toward the bottom 2b of the dissolution tank 2 through the communication pipe 4 is configured to be directed to the stirring blade 3. In this case, since the stirring blade 3 is provided in the flow direction of the solution L that moves the powdered medicine, the wound powder medicine is more easily stirred by the stirring blade 3, and the stirring efficiency is improved. Further improve. In the case where the rotation axis of the stirring blade 3 is arranged so as to be shifted from the central axis X of the dissolution tank 2, for example, the distance D1 from the rotation axis of the stirring blade 3 to the central axis X is the side of the dissolution tank 2 from the central axis X. It is preferable to arrange the rotating shaft of the stirring blade 3 so as to be 15 to 35% of the distance D2 to the inner surface of the part 2a. By setting the distance D1 to be 15 to 35% of the distance D2, the pulverized effect of the solution L in the dissolution tank 2 can be agitated by the stirring blade 3 without impairing the convection effect. it can.

In addition, the shape of the stirring blade 3 is not particularly limited, and a known shape of the stirring blade can be used. The size of the stirring blade 3 is not particularly limited. For example, the diameter of the stirring blade 3 can be 10 to 40% of the diameter (diameter) of the dissolution tank 2. However, in the present embodiment, the stirring blade 3 causes an upward flow (upflow) of the solution L when rotated in one direction, and a downward flow (downflow) of the solution L when rotated in the other direction. ) Is used. When the stirring blade 3 rotates in one direction, as shown in FIG. 1, the solution L around the stirring blade 3 flows upward, and the upward convection of the solution L indicated by the arrow A1 is performed. Cause it to occur. Due to the upward convection of the solution L, a flow from the lower side to the upper side of the solution L can be generated, and the accumulation of the drug on the bottom 2b can be suppressed, and the stirring efficiency is improved. When the stirring blade 3 rotates in the other direction, as shown in FIG. 1, the solution L around the stirring blade 3 flows downward, and the downward convection of the solution L indicated by the arrow A2 is performed. Cause it to occur. In addition to the drug rolling up by the communication pipe 4, the drug deposited on the bottom 2b can be rolled up by this downward convection. Therefore, the stirring blade 3 can be rotated forward and backward by the driving unit M, and the control unit C can perform the stirring operation according to the state of the solution L by changing the driving direction of the driving unit M according to the state. it can.

Next, a dissolution method using the powder dissolution apparatus 1 will be described.

FIG. 4 is a flowchart showing a melting method of the powder melting apparatus 1. In addition, the melt | dissolution method shown below is an example to the last, and is not limited to this embodiment.

First, the powder dissolution apparatus 1 is started by operating the ON / OFF switch 51 of the operation panel 5 or the like. When the powder melting apparatus 1 is activated, the first three-way valve V1 and the second three-way valve V2 are operated while the melting tank 2 is empty, as shown in FIG. The passage 43 is communicated. Thereby, a flow path indicated by an arrow in FIG. 5 is formed, and a circulation path through the communication pipe 4 from the inside of the dissolution tank 2 is secured. In FIG. 5, a portion where the solution L does not flow is indicated by a broken line. Next, the mode selection unit 52 of the operation panel 5 is operated to select the dissolution mode. After the dissolution mode is selected, the liquid volume setting unit 53 is operated to set the preparation liquid volume. When the amount of the preparation liquid is set, the water supply switch 54a of the operation start unit 54 can be operated. When the water supply switch 54a is pushed, water supply into the dissolution tank 2 is started (S1). The amount of water supply is measured by the flow rate sensor 21c. When the predetermined amount of liquid is reached, the control unit C closes the water supply valve 21d and stops the supply of water.

When the water supply step S1 is completed, the stirring switch 54b of the operation start unit 54 can be operated. When the stirring switch 54b is operated, the driving unit M is controlled by the control unit C, and the rotation of the stirring blade 3 is started (stirring step S2). When the stirring blade 3 rotates, the powdered medicine is introduced from the medicine inlet 2c of the dissolution tank 2 (drug supply step S3). It should be noted that the medicine may be input before the water supply step S1 or at the same time. In the present specification, a process of supplying a liquid such as water and a powdery medicine is collectively referred to as a supply process.

After the drug and liquid are supplied to the dissolution tank 2 and the stirring operation of the solution L is performed by the stirring blade 3, the circulation switch 54c of the operation start unit 54 can be operated. When the circulation switch 54c is operated, the pump P is driven by the controller C. More specifically, when the circulation switch 54c is operated, the stirring blade 3 is temporarily stopped, and water is supplied to the dissolution tank 2 in addition to the predetermined amount of water supplied in step S1 described above. This water supply stops after it is sensed that the liquid amount set by the liquid amount detection sensor such as a float sensor has been reached. When the water supply is stopped, the stopped stirring blade 3 is driven again and the pump P is driven, and as shown in FIG. 5, a circulation operation for circulating the solution L through the communication pipe 4 is started (circulation). Step S4). In this specification, the stirring step S2 and the circulation step S4 are collectively referred to as a dissolution step. During the dissolution step, the stirring step S2 and the circulation step S4 may be performed simultaneously, or one of the stirring step S2 and the circulation step S4 may be performed. When the solution L circulates in the communication tube 4, as described above, the solution L is discharged from the communication tube 4 toward the bottom 2b, and the drug deposited on the bottom 2b is wound up from the bottom 2b. The wound-up medicine 2b is further stirred by the stirring blade 3, and the stirring efficiency is improved. When the dissolution process is completed, for example, a part of the solution L is collected from the liquid collection channel 48, and it is confirmed whether there is any undissolved drug (dissolution determination process S5). When it is determined that there is no undissolved portion, the first three-way valve V1 and the second three-way valve V2 are operated as shown in FIG. 6, and the liquid supply path connected to the liquid supply path 45 from the bottom 2b of the dissolution tank 2 Is formed, the solution L is fed (liquid feeding step S6), and the series of steps is completed. In FIG. 6, a portion where the solution L does not flow is indicated by a broken line. In the dissolution determination step S5, when the dissolution is insufficient, such as when there is an undissolved residue, the operation panel 5 is operated again to return to the stirring step S2, and the dissolution step is resumed. Thereafter, when it is determined that there is no problem in the dissolution determination step S5, the solution L is fed. In the liquid feeding step S6, when the liquid feeding is temporarily interrupted, the second three-way valve V2 is operated from the state where the liquid feeding path is formed, and as shown in FIG. 7,

reference numerals

44 and 42b. , 43a, 43c can form a loop-shaped circulation path, and the solution L can be circulated in the circulation path when the liquid feeding is interrupted.

Next, detailed control in the stirring step S2 will be described. In the present embodiment, in the stirring step S2, the control unit C causes the drive unit M to move the solution L stirred by the stirring blade 3 upward for a predetermined time after the stirring blade 3 starts stirring operation. The agitating blade 3 is controlled to rotate so as to convect to (to generate an upward flow). After the medicine is put into the dissolution tank 2 (after the medicine supply step S3 and when the stirring step S2 is performed), a predetermined time after the stirring blade 3 starts the stirring operation (the initial stage of the stirring operation) ) Contains a large amount of undissolved drug in the solution L. In such a situation, the powdery medicine remaining undissolved in the solution L due to the upward flow of the solution L as indicated by the arrow A1 in FIG. It is difficult to settle and the accumulation of the drug on the bottom 2b can be suppressed, and the stirring efficiency is improved. In the present specification, the “predetermined time after the start of the stirring operation” refers to the total amount of time (for example, about 30 minutes at the maximum) during which the stirring operation is performed. This refers to the initial or first half where there is a lot of unmelted residue. The starting point and length of the “predetermined time” are not particularly limited. For example, the starting point is immediately after the stirring operation or the initial stage (for example, within 1 minute), and the length is 5% of the total time of the stirring operation. It can be made 30%.

Further, in the present embodiment, the controller C controls the stirring blade 3 so that the dissolving liquid L stirred by the stirring blade 3 generates a downward flow before the dissolving solution L generates an upward flow by the stirring blade 3. The control unit C is configured to maintain the pump P in a non-driven state while the downflow is occurring. For example, the pump P is stopped for a second predetermined time after the stirring blade 3 starts the stirring operation, and the pump P is driven after the second predetermined time has elapsed. In the initial stage of the stirring step S2, since there is a large amount of undissolved drug in the dissolution tank 2, the powder P is stopped inside the pump P by stopping the pump P for a second predetermined time. Can be prevented from entering. The “second predetermined time” at which the pump P is stopped refers to the initial or first half of the total time during which the stirring operation is performed, in which the powdered medicine is largely undissolved in the solution L, as described above. The time may be the same time as the “predetermined time” when the solution L is convected upward, or may be a different time.

Next, the dissolution process of the drug will be described in more detail using the flowchart of FIG. When the preparation for dissolution in the above-described steps S2 and S3 is completed, the circulation switch 54c can be operated. When the circulation switch 54c is operated, the melting operation is started (step S21). When the melting operation is started, the control unit C controls the driving unit M to rotate the stirring blade 3 so that the dissolving liquid L stirred by the stirring blade 3 generates a downward flow (step S22). . When the stirring blade 3 rotates in the other direction, as shown in FIG. 1, the solution L around the stirring blade 3 flows downward, causing a downward flow of the solution L indicated by an arrow A2. At this time, the pump P is maintained in a non-driven state and is stopped, and the medicine accumulated on the bottom 2b can be wound up by the downward flow caused by the rotation of the stirring blade 3. Therefore, it is possible to further suppress the accumulation of the drug on the bottom 2b. In the present embodiment, the pump P is stopped when the downward flow is generated by the rotation of the stirring blade 3, but when the downward flow is generated by the rotation of the stirring blade 3, the pump P is driven. It doesn't matter. In this case, since the flow of the dissolution liquid L from the communication pipe 4 and the flow of the dissolution liquid L generated by the downward convection partially collide, the dissolution effect is further enhanced by the collision of the flows.

In step S22, a downward flow is generated at the position of the stirring blade 3 toward the bottom 2b of the dissolution tank 2, and then the control unit C controls the drive unit M, and the stirring blade 3 is moved in the opposite direction to step S22. Rotate to generate an upward flow at the position of the stirring blade 3 and drive the pump P (see step S23). When the solution L circulates in the communication tube 4, as described above, the solution L is discharged from the communication tube 4 toward the bottom 2b, and the drug deposited on the bottom 2b is wound up from the bottom 2b. The medicine wound up from the bottom 2 b further raises the flow of the solution L at the position of the stirring blade 3 by the upward flow by the stirring blade 3. Thereby, the chemical | medical agent wound up from the bottom part 2b is further stirred by the stirring blade 3, and stirring efficiency improves.

After step S23, the pump P is stopped, the upward flow is maintained for a while, and the melting operation is continued for a while by upward convection (see step S24). When step S24 is completed, the control unit C determines whether or not the number of repetitions of steps S22 to S24 set in advance has been performed (step S25). When steps S22 to S24 are less than the preset number of repetitions, the process returns to step S22, and when the number of repetitions set in advance is satisfied, the melting operation ends.

Next, another embodiment that performs control according to the set liquid amount of the powder dissolving apparatus 1 will be described with reference to FIG. In the example shown below, the rotation speed of the stirring blade is changed according to the set liquid amount of the dissolving liquid, and stirring according to the set liquid amount is performed, so that optimal stirring according to the liquid amount is possible.

As shown in FIG. 9, after the stirring operation is started (the stirring blade 3 generates a downward flow. Refer to S <b> 31), the liquid amount set by the operation panel 5 is a predetermined predetermined liquid. When the amount of set liquid that can be operated by the operation panel 5 is 25 gallons, 50 gallons, 75 gallons, and 25 gallons smaller than 50 gallons (predetermined liquid amount) are set. ), The process proceeds to step S33, and during the third predetermined time, the rotation speed of the stirring blade 3 is controlled to be equal to or lower than the predetermined rotation speed (first rotation speed). At this time, as described above, the stirring blade 3 rotates so that the dissolved liquid L becomes an upward flow, and the pump P is driven. Here, the rotational speed equal to or lower than the predetermined rotational speed is, for example, a rotational speed that is 40 to 60% of the rotational speed of the stirring blade 3 in the stirring step other than step S33. When the rotational speed of the stirring blade 3 is 700 to 1800 rpm, for example, in step S34 described later, other than step S33, for example, the rotational speed in step S33 can be set to 280 to 1080 rpm. Preferably, when the rotational speed of the stirring blade 3 in step S34 described later is 1000 to 1500 rpm, for example, the rotational speed in step S33 can be set to 400 to 900 rpm. As described above, when the set liquid amount is lower than the predetermined liquid amount, the liquid surface of the solution L is at a low position, so that the air is easily involved by the rotation of the stirring blade 3 and the solution L is easily bubbled. Yes. However, as described above, by reducing the rotation speed of the stirring blade 3 when the set liquid amount is small, it is difficult to entrain air and foaming of the solution L is suppressed. When the set liquid amount is equal to or larger than the predetermined liquid amount, the stirring blade 3 is rotated so that the dissolved liquid L becomes an upward flow at a normal rotational speed as described above (step S35). In step S35, the pump P is driven as in step S33.

In step S33, after the third predetermined time has elapsed, the stirring blade 3 is increased from the first rotational speed equal to or lower than the predetermined rotational speed to the second rotational speed that is greater than the first rotational speed. (S34). In the present embodiment, in step S34, the stirring blade 3 is rotated so that the solution L is in an upward flow, and the pump P is stopped, as in step S33. The second number of rotations is not particularly limited, but can be the same as the number of rotations in a normal stirring step, and can be, for example, 700 to 1800 rpm, preferably 1000 to 1500 rpm. By rotating the stirring blade 3 at the first rotational speed in the step S33 and rotating the stirring blade 3 at the second rotational speed increased in the step S34, a small convection is generated in the dissolution tank 2 at a low rotational speed. Then, large convection can be generated at high rotation, and the foaming of the solution L can be suppressed, and the solution L can be efficiently stirred by the convection. The “third predetermined time” in step S33 can be, for example, 1.5 to 5% of the total time during which the stirring operation is performed. In Step S36, after the predetermined time (fourth predetermined time) has elapsed in Step S35, the stirring blade 3 rotates in the same rotation speed and rotation direction as in Step S35, but the pump P is stopped. The solution L is stirred by convection of the solution L. The fourth predetermined time can be the same time as the third predetermined time.

When step S34 or step S36 is completed, the number of stirring operations actually performed (the number of repetitions of S32 to S34 or S32 to S36) is compared with a preset number of times corresponding to the set liquid amount, Whether or not the predetermined stirring operation has been performed is determined by the control unit C (S37). When the set number of times and the number of stirring operations actually performed are the same, the stirring operation ends in step S38, and when the number of stirring operations actually performed is less than the set number of times, the process returns to S32. The stirring operation is repeated.

As a modification of the embodiment shown in the flowchart of FIG. 9, after S34 or S36, the pump P is further driven to generate a flow from the communication pipe 4 to increase the dissolution efficiency. Specifically, after step S34 or S36, the stirring blade 3 generates a downward flow, and the pump P is driven to collide the flow of the solution L from the communication pipe 4 with the downward flow of the stirring blade 3. By making it, dissolution efficiency can be improved.

Note that the control of the rotation speed of the stirring blade described in the flowchart of FIG. 9 can also be applied in the steps S22 to S24 of the melting operation described in FIG. In this case, for example, steps S23 and S24 in FIG. 8 correspond to steps S33 and S34 or steps S35 and S36 in FIG.

In the said embodiment, although the drive part M, the control part C, and the operation panel 5 showed what was attached to the upper part of the dissolution tank 2, the position which provides the drive part M, the control part C, and the operation panel 5 is especially It is not limited and may be attached to the side 2a or bottom 2b side of the dissolution tank 2, or may not be attached to the dissolution tank 2 and may be provided separately.

Moreover, in the said embodiment, although the stirring blade 3 and the drive shaft 31 showed what extended from the upper part side of the dissolution tank 2, the stirring blade 3 and the drive shaft 31 are extended from the lower side of the dissolution tank 2. FIG. It doesn't matter. In the above embodiment, the first three-way valve V1 and the second three-way valve V2 are manually opened and closed. However, the valves may be automatically controlled by the control unit C.

DESCRIPTION OF SYMBOLS 1 Powder dissolution apparatus 2 Dissolution tank 2a Side part of dissolution tank 2b Bottom part of dissolution tank

2c Chemical inlet

2d Supply port 21 Supply means 21a Supply port 21b Supply pipe 21c Flow rate sensor 21d Supply valve 3 Stirring blade 4 Communication pipe 41a Upper connection Portion 41b Lower side connection portion 42 First communication passage 43 Second communication passage 44 Circulation passage 45 Liquid supply passage 46 Waste liquid passage 47 Overflow pipe 48 Liquid collection passage 5 Operation means (operation panel)
51 ON / OFF switch 52 Mode selection unit 53 Fluid volume setting unit 54 Operation start unit 54a Water supply switch

54b Stirring switch

54c Circulation switch 54d Liquid feeding switch C Control unit D1 Distance from the rotation axis of the stirring blade to the central axis D2 From the central axis Distance to the inner surface of the side of the dissolution tank L Dissolved solution M Drive unit P Pump S Bottom slope T Bottom top V1 First three-way valve V2 Second three-way valve V3 Waste liquid valve V4 Check valve V5 Liquid collection valve X Dissolution Center axis of tank

Claims

A dissolution tank for storing the dissolution liquid, a stirring blade provided in the dissolution tank, a communication pipe communicating between at least two places having different heights in the dissolution tank, and provided in the communication pipe A powder dissolving apparatus comprising a pump,
The stirring blade is disposed at a position spaced a predetermined distance from the bottom of the dissolution tank,
By the driving of the pump, the dissolution liquid in the dissolution tank is sent to the bottom of the dissolution tank through the communication pipe, and the flow of the dissolution liquid discharged from the communication pipe to the dissolution tank is the dissolution tank. The powder dissolution apparatus with which the said dissolution tank and the said communication pipe are connected so that it may flow along the bottom part.
The powder dissolution apparatus according to claim 1, wherein a bottom portion of the dissolution tank is formed in a reverse cone shape, and the communication pipe is connected to a top portion of the bottom portion of the reverse cone shape or a vicinity thereof at a bottom portion of the dissolution tank.
The rotating shaft of the stirring blade is arranged so as to be shifted from the central axis of the dissolution tank toward the side of the dissolution tank, and the flow of the dissolved solution sent to the bottom of the dissolution tank through the communication pipe The powder dissolving apparatus according to claim 1, wherein the powder dissolving apparatus is configured to face the stirring blade.
The powder dissolving device further includes
A drive unit for rotating the stirring blade forward and backward, and
A control unit for controlling the drive unit,
The controller controls the drive unit,
4. The control according to claim 1, wherein the stirring blade is controlled to rotate so that the dissolved liquid stirred by the stirring blade generates an upward flow for a predetermined time after the stirring blade starts the stirring operation. The powder dissolving apparatus of any one of Claims.
The powder dissolution apparatus according to claim 4, wherein the control unit controls the pump so that the pump is driven while the upward flow is generated.
The control unit controls the stirring blade such that the solution stirred by the stirring blade generates a downward flow before the dissolving solution causes the upward flow by the stirring blade. The powder dissolving apparatus according to claim 4 or 5, wherein the pump is maintained in a non-driven state while a downward flow is occurring.
The powder dissolving apparatus according to any one of claims 1 to 6, wherein a rotation speed of the stirring blade is changed according to a set liquid amount of the dissolving liquid.
When the set amount of the stirring liquid is smaller than a predetermined amount, the driving unit drives the stirring blade at the first rotation speed while the upward flow is generated, and then at the second rotation speed. 8. The powder dissolving apparatus according to claim 7, which is controlled by the control unit so as to drive the stirring blade, and the first rotational speed is limited to a predetermined rotational speed for suppressing foaming of the solution. .
A dissolution tank for storing the dissolution liquid, a stirring blade provided in the dissolution tank, a communication pipe communicating between at least two places having different heights in the dissolution tank, and provided in the communication pipe A dissolving method using a powder dissolving apparatus, wherein the stirring blade is disposed at a position spaced apart from the bottom of the dissolving tank by a predetermined distance,
The dissolution method comprises
A supply step of supplying liquid and powdered medicine to the dissolution tank, and a dissolution step of stirring the liquid and powdered medicine to prepare a solution;
In the dissolution step, the solution in the dissolution tank is sent to the bottom side of the dissolution tank through the communication pipe by driving the pump, and the dissolution liquid discharged from the communication pipe to the dissolution tank A melting method in which a flow flows along the bottom of the dissolution tank.
The melting method according to claim 9, wherein a bottom portion of the dissolution tank is formed in an inverted conical shape, and the communication pipe is connected to or near the top of the bottom portion of the inverted cone shape at the bottom portion of the dissolution tank.
The rotating shaft of the stirring blade is arranged so as to be shifted from the central axis of the dissolution tank toward the side of the dissolution tank, and the flow of the dissolved solution sent to the bottom of the dissolution tank through the communication pipe The melting method according to claim 9, wherein the melting method is configured to face the stirring blade.
In the melting step, the stirring blade is rotated so that the dissolved liquid stirred by the stirring blade generates an upward flow for a predetermined time after the stirring blade starts stirring operation. 12. The dissolution method according to any one of 11 above.
The melting method according to claim 12, wherein the pump is driven while the upward flow is generated.
The stirring blade rotates so that the solution stirred by the stirring blade generates a downward flow before the dissolving solution causes the upward flow by the stirring blade. The lysis method according to claim 12 or 13, wherein the pump is maintained in a non-driven state.
The dissolution method according to any one of claims 9 to 14, wherein the rotation speed of the stirring blade is changed according to a set liquid amount of the dissolution liquid.
When the set amount of the stirring liquid is smaller than a predetermined amount, the driving unit drives the second rotation speed after the stirring blade is driven at the first rotation speed while the upward flow is generated. The melting method according to claim 15, wherein the stirring blade is driven and the first rotational speed is limited to a predetermined rotational speed for suppressing foaming of the dissolving liquid.