WO2016161311A8 - In-vitro methods for assessing tissue compatibility of a material - Google Patents

In-vitro methods for assessing tissue compatibility of a material Download PDF

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Publication number
WO2016161311A8
WO2016161311A8 PCT/US2016/025601 US2016025601W WO2016161311A8 WO 2016161311 A8 WO2016161311 A8 WO 2016161311A8 US 2016025601 W US2016025601 W US 2016025601W WO 2016161311 A8 WO2016161311 A8 WO 2016161311A8
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
vitro methods
tissue compatibility
grafts
assessing tissue
Prior art date
Application number
PCT/US2016/025601
Other languages
French (fr)
Other versions
WO2016161311A1 (en
Inventor
Giuseppe Maria DE PEPPO
Original Assignee
The New York Stem Cell Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/064076 external-priority patent/WO2016090297A1/en
Application filed by The New York Stem Cell Foundation filed Critical The New York Stem Cell Foundation
Publication of WO2016161311A1 publication Critical patent/WO2016161311A1/en
Publication of WO2016161311A8 publication Critical patent/WO2016161311A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G01N23/046—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/225—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion
    • G01N23/2251—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion using incident electron beams, e.g. scanning electron microscopy [SEM]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

In some embodiments the present invention provides in vitro methods for assessing a material or device for tissue compatibility, comprising culturing an engineered tissue graft with a test material or device; and determining whether the test material is compatible with the tissue graft. In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts to screen materials and devices for tissue compatibility. In some embodiments the tissue grafts are made using pluripotent stem cells.
PCT/US2016/025601 2015-04-02 2016-04-01 In vitro methods for assessing tissue compatibility of a material WO2016161311A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562142348P 2015-04-02 2015-04-02
US62/142,348 2015-04-02
PCT/US2015/064076 WO2016090297A1 (en) 2014-12-04 2015-12-04 Perfusion bioreactor
USPCT/US2015/064076 2015-12-04

Publications (2)

Publication Number Publication Date
WO2016161311A1 WO2016161311A1 (en) 2016-10-06
WO2016161311A8 true WO2016161311A8 (en) 2016-11-03

Family

ID=57007397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/025601 WO2016161311A1 (en) 2015-04-02 2016-04-01 In vitro methods for assessing tissue compatibility of a material

Country Status (1)

Country Link
WO (1) WO2016161311A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110009562A (en) * 2019-01-24 2019-07-12 北京航空航天大学 A method of comminuted fracture threedimensional model is spliced using template
RU2740566C1 (en) * 2020-06-08 2021-01-15 Федеральное государственное бюджетное учреждение науки Институт металлоорганической химии им. Г.А. Разуваева Российской академии наук (ИМХ РАН) Method of estimating cell migration into structure of material or scaffold
CN113604544B (en) * 2021-08-03 2023-03-10 北京大学口腔医学院 Biological material function prediction and evaluation method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472202B1 (en) * 1998-05-08 2002-10-29 Flexcell International Corporation Loading station assembly and method for tissue engineering
WO2006099016A2 (en) * 2005-03-09 2006-09-21 Providence Health System A composite multi-layered vascular graft prosthesis
US9687348B2 (en) * 2009-03-03 2017-06-27 The Trustees Of Columbia University In The City Of New York Method of making a personalized bone graft
US20100303911A1 (en) * 2009-06-01 2010-12-02 Heather Sheardown Hydrogel systems
WO2012048188A1 (en) * 2010-10-07 2012-04-12 Drixel University Electrospun mineralized chitosan nanofibers crosslinked with genipin for bone tissue enginering
WO2012058617A1 (en) * 2010-10-29 2012-05-03 The Trustees Of Columbia University In The City Of New York Compositions and methods for formation of bone tissue

Also Published As

Publication number Publication date
WO2016161311A1 (en) 2016-10-06

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