WO2016159532A3 - 시크로피록스 함유 네일락카 조성물 - Google Patents

시크로피록스 함유 네일락카 조성물 Download PDF

Info

Publication number
WO2016159532A3
WO2016159532A3 PCT/KR2016/002333 KR2016002333W WO2016159532A3 WO 2016159532 A3 WO2016159532 A3 WO 2016159532A3 KR 2016002333 W KR2016002333 W KR 2016002333W WO 2016159532 A3 WO2016159532 A3 WO 2016159532A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition containing
drug
lacquer composition
nail lacquer
exhibits excellent
Prior art date
Application number
PCT/KR2016/002333
Other languages
English (en)
French (fr)
Other versions
WO2016159532A2 (ko
Inventor
김남향
조용백
정상영
배병찬
이재성
이지원
조홍구
Original Assignee
한국콜마주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국콜마주식회사 filed Critical 한국콜마주식회사
Priority to US15/555,619 priority Critical patent/US11154542B2/en
Priority to JP2017545753A priority patent/JP6461368B2/ja
Priority to CN201680018413.XA priority patent/CN107427436A/zh
Publication of WO2016159532A2 publication Critical patent/WO2016159532A2/ko
Publication of WO2016159532A3 publication Critical patent/WO2016159532A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 1 종 이상의 항진균제를 약리학적 활성성분으로 하는 네일락카 조성물에 관한 것이다. 본 발명은 특정 필름형성 고분자물질 및 투과촉진제 등을 함유함으로써 치료가 요구되어 약물을 도포한 피부 부위에서의, 구체적으로는 조갑에서의 그 약물의 침투 효과가 우수하며, 약물의 치료 부위에의 국소 도포 후 그 관리 등이 편리하고, 약물의 저장안정성이 우수하다는 것이 특징이다.
PCT/KR2016/002333 2015-03-28 2016-03-09 시크로피록스 함유 네일락카 조성물 WO2016159532A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/555,619 US11154542B2 (en) 2015-03-28 2016-03-09 Nail lacquer composition containing ciclopirox
JP2017545753A JP6461368B2 (ja) 2015-03-28 2016-03-09 シクロピロックス含有ネイルラッカー組成物
CN201680018413.XA CN107427436A (zh) 2015-03-28 2016-03-09 含有环吡酮的指甲油组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0043724 2015-03-28
KR1020150043724A KR101580077B1 (ko) 2015-03-28 2015-03-28 시크로피록스 함유 네일락카 조성물

Publications (2)

Publication Number Publication Date
WO2016159532A2 WO2016159532A2 (ko) 2016-10-06
WO2016159532A3 true WO2016159532A3 (ko) 2016-11-24

Family

ID=55084378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/002333 WO2016159532A2 (ko) 2015-03-28 2016-03-09 시크로피록스 함유 네일락카 조성물

Country Status (5)

Country Link
US (1) US11154542B2 (ko)
JP (1) JP6461368B2 (ko)
KR (1) KR101580077B1 (ko)
CN (2) CN112957359A (ko)
WO (1) WO2016159532A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019214838A1 (en) * 2018-05-09 2019-11-14 Eviderm Institute Ab Use of an alcohol-containing composition for improving the skin barrier function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001523273A (ja) * 1998-02-09 2001-11-20 マクロケム・コーポレーシヨン 抗真菌性爪ラッカーおよびそれの使用方法
KR20030016237A (ko) * 2000-03-09 2003-02-26 아벤티스 파마 도이칠란트 게엠베하 항-감염성 활성 성분 배합물, 및 손발톱의 진균성 질환의국부적인 치료를 위한 이들의 용도
JP2005503318A (ja) * 2000-02-16 2005-02-03 ベントレー ファーマシューティカルズ インコーポレイテッド 医薬組成物
WO2006013963A1 (ja) * 2004-08-05 2006-02-09 Hisamitsu Pharmaceutical Co., Inc. 爪用外用剤
KR100551930B1 (ko) * 1996-11-22 2006-02-16 코네틱스 오스트레일리아 피티와이 리미티드 경피 전달계

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3803393B2 (ja) * 1994-01-12 2006-08-02 久光製薬株式会社 爪白癬治療用組成物
DE10035991A1 (de) 2000-07-24 2002-02-14 Polichem Sa Nagellackzusammensetzung
WO2005011565A2 (fr) * 2003-07-29 2005-02-10 Pierre Fabre Dermo-Cosmetique Vernis a ongles a action antimycosique
NZ598441A (en) * 2005-02-16 2013-07-26 Anacor Pharmaceuticals Inc Boron-containing small molecules
CN101262848B (zh) * 2005-09-29 2011-05-11 诺瓦提斯公司 抗真菌组合物
GB0720716D0 (en) * 2007-10-23 2007-12-05 York Pharma Plc Novel formulation
CA2763911C (en) * 2009-05-29 2018-01-30 Palau Pharma, S.A. Azole antifungal compositions
CA2864910C (en) 2012-02-17 2018-07-24 Joseph CAPRIOTTI Antifungal compositions for the treatment of skin and nails
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100551930B1 (ko) * 1996-11-22 2006-02-16 코네틱스 오스트레일리아 피티와이 리미티드 경피 전달계
JP2001523273A (ja) * 1998-02-09 2001-11-20 マクロケム・コーポレーシヨン 抗真菌性爪ラッカーおよびそれの使用方法
JP2005503318A (ja) * 2000-02-16 2005-02-03 ベントレー ファーマシューティカルズ インコーポレイテッド 医薬組成物
KR20030016237A (ko) * 2000-03-09 2003-02-26 아벤티스 파마 도이칠란트 게엠베하 항-감염성 활성 성분 배합물, 및 손발톱의 진균성 질환의국부적인 치료를 위한 이들의 용도
WO2006013963A1 (ja) * 2004-08-05 2006-02-09 Hisamitsu Pharmaceutical Co., Inc. 爪用外用剤

Also Published As

Publication number Publication date
WO2016159532A2 (ko) 2016-10-06
US11154542B2 (en) 2021-10-26
JP6461368B2 (ja) 2019-01-30
CN107427436A (zh) 2017-12-01
US20180104227A1 (en) 2018-04-19
KR101580077B1 (ko) 2015-12-24
JP2018507225A (ja) 2018-03-15
CN112957359A (zh) 2021-06-15

Similar Documents

Publication Publication Date Title
CA3148745A1 (en) Kras g12d inhibitors
EP3690050A4 (en) MULTISPECIFIC ANTIGEN-BINDING MOLECULE HAVING SUBSTITUTION ACTIVITY FOR THE FUNCTION OF BLOOD COAGULATION FACTOR VIII COFACTOR (FVIII), AND PHARMACEUTICAL FORMULATION CONTAINING THE SAME MOLECULE AS ACTIVE PRINCIPLE
WO2017191130A3 (en) Arginase inhibitors and their therapeutic applications
WO2017091739A8 (en) Topical film-forming spray
WO2015142001A3 (ko) 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물
WO2012160180A3 (en) Pharmaceutical composition for administration to nails
CA2492976A1 (en) Solution for ungual and peri-ungual application
WO2016012420A3 (de) Deodorantzubereitungen umfassend polyquaternium-6-polymere
WO2017037075A8 (de) Zusammensetzung enthaltend einen extrakt aus echinacea und linolsäurederivate
WO2016116403A8 (en) Polyurethaneurea solutions for compositions with active ingredients or fragrances
WO2015066302A3 (en) Compositions, methods of use, and methods of treatment
WO2019108021A3 (ko) 토파시티닙을 포함하는 약제학적 조성물
EP3827810A4 (en) COSMETIC COMPOSITION WITH EXOSOME DERIVED FROM GALACTOMYCES AS ACTIVE INGREDIENT
ZA202305623B (en) A composition and related methods of manufacture and use
WO2021046315A3 (en) Inhibitors of encephalitic alphaviruses
WO2016036966A8 (en) Hydrazinyl lipidoids and uses thereof
EP3449920A4 (en) COMPOSITION USING NAPHTHOCHINONE - BASED COMPOUND AS ACTIVE AGENT FOR PREVENTING OR PREVENTING TEMPERATURE, CACHEXIA, PAIN, COGNITIVE DECONTAMINATION AND REDUCTION OF HEMATOPOETIC STEM CELLS AS SIDE EFFECTS RELATED TO A MEDICAMENTAL OIL CANCER TREATMENT
WO2016159532A3 (ko) 시크로피록스 함유 네일락카 조성물
MX2020008929A (es) Compuestos de dihidropirimidinona o dihidrotriazinona fusionados con anillos saturados y su uso farmaceutico.
AU2017370226A1 (en) Pharmaceutical composition containing insulin-like growth factor-2 and use thereof
WO2016093554A3 (ko) 신규한 4-(아릴)-n-(2-알콕시티에노[3,2-b]피라진-3-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
WO2018140853A8 (en) Transglutaminase treated products
AU2017258649A1 (en) Covalent BTK inhibitors and uses thereof
EP4015042A4 (en) PHARMACEUTICAL COMPOSITION WITH ANTIFUNGAL AS AN ACTIVE SUBSTANCE
PH12017500536A1 (en) Solid pharmaceutical composition comprising amlodipine and losartan

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16773313

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2017545753

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 15555619

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16773313

Country of ref document: EP

Kind code of ref document: A2