WO2016126073A3 - 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물 - Google Patents

알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물 Download PDF

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Publication number
WO2016126073A3
WO2016126073A3 PCT/KR2016/001111 KR2016001111W WO2016126073A3 WO 2016126073 A3 WO2016126073 A3 WO 2016126073A3 KR 2016001111 W KR2016001111 W KR 2016001111W WO 2016126073 A3 WO2016126073 A3 WO 2016126073A3
Authority
WO
WIPO (PCT)
Prior art keywords
biguanide
pharmaceutical composition
stem cells
based compound
cancer stem
Prior art date
Application number
PCT/KR2016/001111
Other languages
English (en)
French (fr)
Other versions
WO2016126073A2 (ko
Inventor
강석구
장종희
김의현
이지현
조윤희
박준성
심진경
김수열
Original Assignee
연세대학교 산학협력단
국립암센터
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160010118A external-priority patent/KR101765575B1/ko
Application filed by 연세대학교 산학협력단, 국립암센터 filed Critical 연세대학교 산학협력단
Priority to ES16746814T priority Critical patent/ES2893155T3/es
Priority to DK16746814.9T priority patent/DK3254680T3/da
Priority to EP16746814.9A priority patent/EP3254680B1/en
Priority to CN201680008269.1A priority patent/CN107205963B/zh
Priority to US15/547,860 priority patent/US20180015056A1/en
Priority to JP2017540723A priority patent/JP6469877B2/ja
Publication of WO2016126073A2 publication Critical patent/WO2016126073A2/ko
Publication of WO2016126073A3 publication Critical patent/WO2016126073A3/ko
Priority to US16/400,514 priority patent/US10646460B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물에 관한 것이다. 본 발명에 따른 약학적 조성물은 알데히드 억제제와 비구아나이드 계열 화합물을 함께 사용하여, 신경구 등의 암 줄기세포의 성장을 효과적으로 저해하고, 암 세포의 증식, 침윤 및 전이 또한 억제하여 뇌암 등의 암을 예방 및/또는 치료할 수 있다.
PCT/KR2016/001111 2015-02-02 2016-02-02 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물 WO2016126073A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES16746814T ES2893155T3 (es) 2015-02-02 2016-02-02 Composición farmacéutica para inhibir el crecimiento de células madre de cáncer, que contiene un inhibidor de aldehído y un compuesto a base de biguanida
DK16746814.9T DK3254680T3 (da) 2015-02-02 2016-02-02 Farmaceutisk sammensætning til hæmning af cancerstamcellers vækst indeholdende aldehydhæmmer og biguanidbaseret forbindelse
EP16746814.9A EP3254680B1 (en) 2015-02-02 2016-02-02 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound
CN201680008269.1A CN107205963B (zh) 2015-02-02 2016-02-02 含有醛抑制剂和双胍类化合物的抑制癌症干细胞生长的药物组合物
US15/547,860 US20180015056A1 (en) 2015-02-02 2016-02-02 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound
JP2017540723A JP6469877B2 (ja) 2015-02-02 2016-02-02 アルデヒド抑制剤およびビグアナイド系化合物を含む癌幹細胞の成長抑制用薬学的組成物
US16/400,514 US10646460B2 (en) 2015-02-02 2019-05-01 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20150016295 2015-02-02
KR10-2015-0016295 2015-02-02
KR10-2016-0010118 2016-01-27
KR1020160010118A KR101765575B1 (ko) 2015-02-02 2016-01-27 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/547,860 A-371-Of-International US20180015056A1 (en) 2015-02-02 2016-02-02 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound
US16/400,514 Continuation US10646460B2 (en) 2015-02-02 2019-05-01 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound

Publications (2)

Publication Number Publication Date
WO2016126073A2 WO2016126073A2 (ko) 2016-08-11
WO2016126073A3 true WO2016126073A3 (ko) 2016-10-06

Family

ID=56564852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/001111 WO2016126073A2 (ko) 2015-02-02 2016-02-02 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물

Country Status (1)

Country Link
WO (1) WO2016126073A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101579371B1 (ko) * 2014-02-27 2015-12-22 국립암센터 고시폴 및 펜포르민을 유효성분으로 함유하는 암 치료용 약제학적 조성물
KR101904893B1 (ko) 2016-02-18 2018-10-10 연세대학교 산학협력단 폴리페놀 화합물을 유효성분으로 포함하는 암 치료용 약학조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130015669A (ko) * 2011-08-04 2013-02-14 한올바이오파마주식회사 암의 재발 또는 전이의 억제용 약제학적 조성물
KR101242726B1 (ko) * 2012-01-26 2013-03-13 한국과학기술원 종양줄기세포 특성 암의 진단 및 치료제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130015669A (ko) * 2011-08-04 2013-02-14 한올바이오파마주식회사 암의 재발 또는 전이의 억제용 약제학적 조성물
KR101242726B1 (ko) * 2012-01-26 2013-03-13 한국과학기술원 종양줄기세포 특성 암의 진단 및 치료제

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
APPLEYARD, M. V. C. L. ET AL.: "Phenformin as Prophylaxis and Therapy in Breast Cancer Xenografts.", BRITISH JOURNAL OF CANCER, vol. 106, no. 6, 2012, pages 1117 - 1122, XP055317644 *
KOPPAKA, V. ET AL.: "Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action", SUBSTRATE SPECIFICITY, AND CLINICAL APPLICATION. PHARMACOLOGICAL REVIEWS, vol. 64, no. 3, 2012, pages 520 - 539, XP055246215 *
MEGO, M.: "Telomerase Inhibitors in Anticancer Therapy Gossypol as a Potential Telomerase Inhibitor.", BRATISLAVSKE LEKARSKE LISTY, vol. 103, no. 10, 2002, pages 378 - 381, XP055317641 *

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