WO2016104892A1 - 유체 속도 측정 장치 - Google Patents
유체 속도 측정 장치 Download PDFInfo
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- WO2016104892A1 WO2016104892A1 PCT/KR2015/006451 KR2015006451W WO2016104892A1 WO 2016104892 A1 WO2016104892 A1 WO 2016104892A1 KR 2015006451 W KR2015006451 W KR 2015006451W WO 2016104892 A1 WO2016104892 A1 WO 2016104892A1
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- Prior art keywords
- light source
- light
- channel
- fluid
- sensor
- Prior art date
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- 238000005259 measurement Methods 0.000 claims description 11
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- 238000000338 in vitro Methods 0.000 description 2
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
- G01P5/26—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the direct influence of the streaming fluid on the properties of a detecting optical wave
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/66—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
- G01F1/661—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters using light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
- G01F1/708—Measuring the time taken to traverse a fixed distance
- G01F1/7086—Measuring the time taken to traverse a fixed distance using optical detecting arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
- G01P5/18—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the time taken to traverse a fixed distance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P3/00—Measuring linear or angular speed; Measuring differences of linear or angular speeds
- G01P3/36—Devices characterised by the use of optical means, e.g. using infrared, visible, or ultraviolet light
- G01P3/366—Devices characterised by the use of optical means, e.g. using infrared, visible, or ultraviolet light by using diffraction of light
Definitions
- the present invention relates to a fluid velocity measuring apparatus, and more particularly to a fluid velocity measuring apparatus for measuring the velocity of the fluid using the refractive index of the light emitted from the two light sources.
- in vitro diagnostic devices use body fluids such as blood and urine as samples, detect substances to be analyzed, and quickly determine the presence or absence of diseases through quantitative analysis. It has such advantages.
- biosensors that can be used in a variety of ways, from diagnosis of pregnancy to screening for various diseases such as cancer and multiple sclerosis, use microscopic proteins such as antibodies and DNA.
- Related prior art documents include Korean Laid-Open Patent Publication No. 2009-0108428.
- the flow rate inside the microfluidic channel may vary due to the difference in the viscosity of plasma in each patient.
- flow velocity measurement is very important in flow cytometry, cell sorting, and micro flow switch.
- the device for measuring the velocity of a fluid is complex or oversized, which is expensive or low accuracy.
- An object of the present invention is to provide a fluid velocity measuring device capable of producing at a low production cost and having high measurement accuracy.
- An object of the present invention is to provide a fluid velocity measuring device that can be easily installed and used by a user and has high measurement accuracy.
- a channel provided with a passage through which fluid can flow;
- a first light source and a second light source positioned in one of the upper and lower portions of the channel;
- a sensor installed in an area opposite to a region where the first and second light sources are located with respect to the channel to receive light emitted from the first and second light sources;
- a velocity calculator configured to calculate a velocity of the fluid using the intensity of light received by the sensor.
- the fluid velocity measuring apparatus can be easily installed and used by all users by using two light sources and sensors of low production cost.
- the production cost is low, the accuracy of the measurement is high.
- FIG. 1 to 2 are views showing a fluid velocity measuring device according to an embodiment of the present invention.
- FIG 3 is a graph illustrating the principle of measuring the velocity of a fluid through a fluid velocity measuring apparatus according to an embodiment of the present invention.
- FIG. 4 is a view showing a fluid velocity measuring device according to another embodiment of the present invention.
- 5 to 7 are graphs for explaining the principle of the velocity measurement and flow rate control of the fluid through the fluid velocity measurement apparatus according to an embodiment of the present invention.
- the velocity of the fluid described herein may mean the rate at which the fluid fills the channel.
- the flow rate control herein may mean controlling the flow rate in the process of filling the channel with the fluid.
- FIG. 1 to 2 are views showing a fluid velocity measuring device according to an embodiment of the present invention.
- the fluid velocity measuring apparatus 100 may include a channel 110, a first light source 121, a second light source 122, a sensor 130, and a speed calculator 140.
- the channel 110 is provided with a passage through which fluid can flow.
- the fluid may comprise a microfluid and may be a specimen.
- Specimen refers to a solution to be detected and means a substance suspected of containing an analyte.
- the sample may contain any biological source such as physiological fluids, including blood, saliva, cerebrospinal fluid, sweat, urine, milk, ascites, mucus, nasal fluid, hemoptysis, arterial blood, peritoneal fluid, and the like ( For example, humans, animals, etc.).
- the sample may be obtained directly from a biological source, or may be used after a pretreatment to modify the properties of the sample is performed.
- Pretreatment may include filtration, precipitation, dilution, mixing, concentration, inactivation of interference components, lysis, addition of reagents, and the like.
- measures such as separating plasma from blood may be performed.
- the first light source 121 and the second light source 122 may be located in an upper region of the channel 110, and the sensor 130 may be installed in a lower region of the channel.
- the first light source 121 and the second light source 122 may be located in the lower region of the channel 110, and the sensor 130 may be installed in the upper region of the channel. That is, according to the exemplary embodiment of the present invention, the sensor 130 may be installed in an area opposite to the area where the first light source 121 and the second light source 122 are located based on the channel 110.
- the first light source 121 and the second light source 122 may be positioned such that light is incident at a predetermined angle with respect to the channel 110 rather than 90 degrees.
- light may be reflected or scattered to cause light to spread. Can fall.
- angles formed between the first light source 121 and the second light source 122 may be positioned not parallel to each other.
- the first light source 121 and the second light source 122 form an angle of 180 degrees (that is, parallel to each other)
- the light emitted from the first light source 121 and the second light source 122 is received.
- the cost is increased because the size of the sensor 130 must be increased.
- the angle and direction of the first light source 121 and the second light source with respect to the channel 110 are adjustable.
- 2 illustrates an example in which an angle formed by the first light source 121 and the second light source 122 with respect to the channel 110 is adjusted in FIG. 1.
- the angle and direction of the first light source 121 and the second light source 122 may be adjusted according to the type of laser light emitted from the first light source 121 and the second light source 122.
- the angle and direction of the first light source 121 and the second light source 122 can be adjusted according to the structure of the chip support (not shown) or the shape of the chip.
- the sensor 130 may be installed in the lower region of the channel 110 to receive light emitted from the first light source 121 and the second light source 122.
- the sensor 130 may be installed to receive all the light emitted from the two light sources 121 and 122. That is, the fluid velocity measuring apparatus according to an embodiment of the present invention may have a structure in which one sensor receives the light of both light sources, thereby reducing the cost.
- the light emitted from the first light source 121 and the second light source 122 crosses each other in the lower region of the channel 110, and then receives the light to the sensor 130.
- the first light source 121, the second light source 122, and the sensor 130 may be located. As described above, the light intersecting in the lower region of the channel 110 is received by the sensor 130, thereby reducing the size of the sensor 130.
- the distance k between the sensor 130 and the channel 110 increases, the intensity of light received by the sensor 130 is weakened, so that the accuracy of the measurement may be lowered. Therefore, the distance k may be 0.1 mm to 10 mm in consideration of the kind of the microfluid and the distance to the light source.
- the size of the sensor 130 may vary depending on the distance (d). Therefore, the distance d may be 1 mm to 10 mm in consideration of the point of the microfluid measured.
- the speed measuring unit 140 may measure the speed of the fluid using the light intensity of the light received from the sensor 130.
- FIG 3 is a graph illustrating the principle of measuring the velocity of a fluid through a fluid velocity measuring apparatus according to an embodiment of the present invention.
- the graph shown may be divided into three regions by a vertical dotted line.
- the left region shows a state in which the two light emitted from the first light source 121 and the second light source 122 are not refracted and received by the sensor 130 because no fluid flows inside the channel 110.
- the fluid flows only to a partial region inside the channel 110, and the light emitted from the first light source 121 is refracted and received by the sensor 130, but all of the light emitted from the second light source 122 is refracted.
- the state received by the sensor 130 is not shown.
- the right region shows a state in which the fluid flows sufficiently in the first channel 110 and the two light emitted from the first light source 121 and the second light source 122 are refracted and received by the sensor 130.
- the light intensity is light at a first refraction time point (when the light of the first light source begins to be refracted) and at a second refraction time point (when the light of the second light source starts to be refracted).
- the change of intensity takes place.
- the time t of the fluid flowing through the distance d may be measured as a time difference of the refraction time point.
- the velocity calculator 140 may calculate the velocity of the fluid using the time t and the distance d.
- the fluid velocity measuring device may adjust the flow velocity of the fluid based on the measured velocity of the fluid.
- FIG. 4 is a view showing a fluid velocity measuring device according to another embodiment of the present invention.
- the fluid velocity measuring device 200 includes a channel 210, a first light source 221, a second light source 222, a sensor 230, a speed calculator 240, and an adjuster 250. It may include.
- the channel 210 is provided with a passage through which fluid can flow.
- the fluid may comprise a microfluid and may be a specimen.
- the first light source 221 and the second light source 222 may be located in an upper region of the channel 210, and the sensor 230 may be installed in a lower region of the channel.
- the first light source 221 and the second light source 222 may be located in the lower region of the channel 210, and the sensor 230 may be installed in the upper region of the channel. That is, according to the exemplary embodiment of the present invention, the sensor 230 may be installed in an area opposite to the area where the first light source 221 and the second light source 222 are located based on the channel 210.
- the first light source 221 and the second light source 222 may be positioned such that light is incident at a predetermined angle with respect to the channel 210 instead of 90 degrees.
- light may be reflected or scattered to cause light to spread. Can fall.
- angles formed between the first light source 221 and the second light source 222 may be positioned not parallel to each other.
- the first light source 221 and the second light source 222 form an angle of 180 degrees (that is, parallel to each other)
- the light emitted from the first light source 221 and the second light source 222 may be used.
- the cost is increased because the size of the sensor 230 must be increased.
- the angle and direction of the first light source 221 and the second light source with respect to the channel 210 are adjustable.
- the angle and direction of the first light source 221 and the second light source 222 may be adjusted according to the type of laser light emitted from the first light source 221 and the second light source 222.
- the angle and direction of the first light source 221 and the second light source 222 may be adjusted according to the structure of the chip support (not shown) or the shape of the chip.
- the sensor 230 may be installed in the lower region of the channel 210 to receive light emitted from the first light source 221 and the second light source 222.
- the sensor 230 may be installed to receive all the light emitted from the two light sources 221 and 222. That is, the fluid velocity measuring apparatus according to an embodiment of the present invention may have a structure in which one sensor receives the light of both light sources, thereby reducing the cost.
- the light emitted from the first light source 221 and the second light source 222 crosses each other in the lower region of the channel 210 and then receives the light to the sensor 130.
- the first light source 221, the second light source 222, and the sensor 230 may be located. As described above, the light intersecting in the lower region of the channel 210 is received by the sensor 230, thereby reducing the size of the sensor 230.
- the speed measuring unit 240 may measure the speed of the fluid using the light intensity of the light received from the sensor 130. Velocity measurement of the fluid can be applied as described in FIG.
- the adjuster 250 may adjust the flow rate of the flowing fluid based on the calculated velocity of the fluid.
- the control unit 250 may include a vent hole 251, a tube 252, a valve 253, and a controller 254.
- the vent hole 251 may be connected to the outside of the channel 210 to discharge the air inside the channel 210 to the outside.
- the valve 253 may be connected to the inlet of the vent hole 251 through a tube 252 to open and close the inlet of the vent hole 251 according to a preset time.
- the controller 254 may control the operation of the valve 253.
- the controller 254 may apply an on signal and an off signal to the valve 253 based on the calculated velocity of the fluid.
- the controller 254 may determine an application time, an application frequency, an application order of the on signal and the off signal.
- the control unit 254 may be stored in the table, the application time, the number of times, the order of application of the on signal and the off signal of the valve 253 according to the flow rate of the fluid.
- the controller 254 may control the valve 253.
- the controller 254 may alternately apply the on signal and the off signal to the valve 253.
- the controller 254 may set the time at which the on signal is applied and the signal at which the off signal is applied to be different from each other. In more detail, a time for which the on signal is applied may be shorter than a signal for applying the off signal.
- the controller 254 may apply the on signal to the valve 253 for a first time when the flow rate of the fluid is the first flow rate.
- the controller 254 may apply the off signal to the valve 253 for a second time.
- the first time and the second time may be formed differently from each other as described above.
- FIG. 5 is a graph illustrating a principle of flow rate control through a fluid velocity measuring apparatus according to an exemplary embodiment of the present invention.
- the material flowing in the channel 210 is subjected to air pressure due to the air in the channel 210, and the resistance due to the air pressure is capillary force due to the channel. If the same as, the material inside the channel may not move. And since the viscosity of the fluid changes over time, it is possible to adjust the flow rate in consideration of the viscosity of the fluid to be changed.
- FIG. 6 shows the flow rate and the time relationship when tp is constant
- FIG. 7 shows the relationship between the measured flow rate and the moving distance of the fluid.
- the moving distance increases at the same opening time, so the open time should be shortened and the closing time should be increased.
- the faster the flow rate the greater the moving distance per unit time, so that the flow rate must be constant by adjusting the open time.
- the velocity measurement of the fluid according to an embodiment of the present invention is applicable to a fluid that is transparent because it uses the refractive index of light.
- the above-described fluid velocity measurement and flow rate control method may be embodied in the form of program instructions that can be executed by various computer means and recorded on a computer-readable recording medium.
- the computer-readable recording medium may include program instructions, data files, data structures, and the like, alone or in combination.
- the program instructions recorded on the recording medium may be those specially designed and configured for the present invention, or may be known and available to those skilled in computer software.
- Computer-readable recording media include magnetic media such as hard disks, floppy disks, and magnetic tape, optical media such as CD-ROMs, DVDs, and magnetic disks such as floppy disks. Magnetic-Optical Media, and hardware devices specifically configured to store and execute program instructions, such as ROM, RAM, flash memory, and the like.
- the recording medium may be a transmission medium such as an optical or metal wire, a waveguide, or the like including a carrier wave for transmitting a signal specifying a program command, a data structure, or the like.
- program instructions include not only machine code generated by a compiler, but also high-level language code that can be executed by a computer using an interpreter or the like.
- the hardware device described above may be configured to operate as one or more software modules to perform the operations of the present invention, and vice versa.
- the above-described fluid velocity measuring device is not limited to the configuration and method of the above-described embodiments, but the embodiments may be selectively combined with each or all of the embodiments so that various modifications can be made. It may be configured.
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Abstract
Description
Claims (7)
- 유체가 흐를 수 있는 통로가 마련된 채널;상기 채널 상부 및 하부 중 어느 한 영역에 위치한 제1광원 및 제2광원;상기 채널을 기준으로 상기 제1광원 및 제2광원이 위치한 영역의 반대 영역에 설치되어 상기 제1광원 및 상기 제2광원으로부터 발광된 빛을 수광하는 센서; 및상기 센서에서 수광한 빛의 세기를 이용하여 상기 유체의 속도를 산출하는 속도 산출부를 포함하는 것을 특징으로 하는 유체 속도 측정 장치.
- 제 1 항에 있어서, 상기 속도 산출부는상기 빛의 세기의 변화 시점 및 상기 제1광원에서 발광한 빛이 상기 채널과 만나는 제1입사 지점과 상기 제2광원에서 발광한 빛이 상기 채널과 만나는 제2입사 지점 사이의 거리 정보를 이용하여 상기 유체의 속도를 산출하는 것을 특징으로 하는 유체 속도 측정 장치.
- 제 2 항에 있어서,상기 제1광원과 상기 제2광원이 상기 채널에 대해 이루는 각도는 조절 가능한 것을 특징으로 하는 유체 속도 측정 장치.
- 제 2 항에 있어서, 상기 센서의 크기는상기 채널과 상기 센서 사이의 거리에 근거해서 결정되는 것을 특징으로 하는 유체 속도 측정 장치.
- 제 2 항에 있어서, 상기 제1광원의 위치 및 상기 제2광원은상기 채널을 통해 형성된 유체의 흐름 방향에 대해 발광되는 빛이 수직하게 입사되지 않도록 위치하는 것을 특징으로 하는 유체 속도 측정 장치.
- 제 2 항에 있어서, 상기 제1광원의 위치 및 상기 제2광원은상기 제1광원으로부터 발광되는 빛과 상기 제2광원으로부터 발광되는 빛이 서로 평행하게 진행되지 않도록 위치하는 것을 특징으로 하는 유체 속도 측정 장치.
- 제 6 항에 있어서, 상기 제1광원 및 상기 제2광원으로부터 발광된 빛은상기 반대 영역에서 서로 교차된 후에 상기 센서로 수광되는 것을 특징으로 하는 유체 속도 측정 장치.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017533531A JP6361903B2 (ja) | 2014-12-22 | 2015-06-24 | 流体速度測定装置 |
CN201580069327.7A CN107110882B (zh) | 2014-12-22 | 2015-06-24 | 流体速度测定装置 |
EP15873420.2A EP3239720B1 (en) | 2014-12-22 | 2015-06-24 | Apparatus for measuring fluid velocity |
US15/518,288 US10502754B2 (en) | 2014-12-22 | 2015-06-24 | Apparatus for measuring fluid speed |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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KR1020140185973A KR101605638B1 (ko) | 2014-12-22 | 2014-12-22 | 유체 속도 측정 장치 |
KR10-2014-0185973 | 2014-12-22 |
Publications (1)
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WO2016104892A1 true WO2016104892A1 (ko) | 2016-06-30 |
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PCT/KR2015/006451 WO2016104892A1 (ko) | 2014-12-22 | 2015-06-24 | 유체 속도 측정 장치 |
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US (1) | US10502754B2 (ko) |
EP (1) | EP3239720B1 (ko) |
JP (1) | JP6361903B2 (ko) |
KR (1) | KR101605638B1 (ko) |
CN (1) | CN107110882B (ko) |
WO (1) | WO2016104892A1 (ko) |
Families Citing this family (4)
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CN107110883B (zh) * | 2014-12-22 | 2020-01-31 | 英泰克生物有限公司 | 流体速度测定装置 |
WO2018204615A1 (en) * | 2017-05-04 | 2018-11-08 | University Of Connecticut | Assembly for measuring the viscosity of fluids using microchannels |
CN111229345B (zh) * | 2020-01-22 | 2021-01-15 | 浙江大学 | 一种基于微纳光纤的微流控芯片流速传感器 |
CN111948423A (zh) * | 2020-08-24 | 2020-11-17 | 山东理工大学 | 一种基于石墨烯的流速传感器光学芯片及其应用 |
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JP6361903B2 (ja) | 2018-07-25 |
US20170307650A1 (en) | 2017-10-26 |
CN107110882B (zh) | 2020-01-31 |
KR101605638B1 (ko) | 2016-03-22 |
EP3239720A1 (en) | 2017-11-01 |
CN107110882A (zh) | 2017-08-29 |
EP3239720A4 (en) | 2018-05-30 |
US10502754B2 (en) | 2019-12-10 |
EP3239720B1 (en) | 2021-03-10 |
JP2018503816A (ja) | 2018-02-08 |
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