WO2016091738A1 - Adhésif pour prothèse dentaire - Google Patents

Adhésif pour prothèse dentaire Download PDF

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Publication number
WO2016091738A1
WO2016091738A1 PCT/EP2015/078625 EP2015078625W WO2016091738A1 WO 2016091738 A1 WO2016091738 A1 WO 2016091738A1 EP 2015078625 W EP2015078625 W EP 2015078625W WO 2016091738 A1 WO2016091738 A1 WO 2016091738A1
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WO
WIPO (PCT)
Prior art keywords
composition
denture adhesive
weight
bioactive glass
oxide
Prior art date
Application number
PCT/EP2015/078625
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English (en)
Inventor
Shirin GHADERI
Shazada Yassar KHAN
Nima ROOHPOUR
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Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of WO2016091738A1 publication Critical patent/WO2016091738A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/836—Glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A61K6/35—Preparations for stabilising dentures in the mouth

Definitions

  • the present invention relates to denture adhesive compositions, their use and methods of making such compositions.
  • Dentures are substitutes for missing teeth and serve as a replacement for all or some of the teeth found in the oral cavity.
  • dentures do not always fit perfectly. Over time, even well-fitting dentures can become ill-fitting due to natural shrinkage and changes in the gum or oral mucosa. Therefore, adherent creams, gels or powders are often used to secure or temporarily fix dentures within the mouth.
  • Denture adhesive compositions are used to fill the interstices between the dentures and the gums or tissues. Prior to placement of the denture in the oral cavity, a denture adhesive or fixative is applied to the denture plate surface, which for a perfect fit, should uniformly contact the gums and oral tissues. Of course, the denture adhesive must also be releasable so that the denture wearer may remove the dentures for cleaning and maintenance. Denture adhesives are generally sold as a cream, liner or strip, liquid, gel or powder, and many examples are well known in the art. Over the years considerable effort has been made to develop improved denture adhesive compositions.
  • a denture adhesive comprising a substantially anhydrous mixture of a cationic derivative of guar gum, a mixed sodium/calcium salt of methyl vinyl ether-maleic anhydride and sodium carboxymethylcellulose.
  • the compositions are in the form of a powder or a paste and are said to provide increased hold power, cushioning, duration of hold and reduced oozing.
  • WO1992/22280 (Richardson Vicks, Inc.), describes denture stabilizing compositions having improved hold, comprising specific mixed partial salts of lower alkyl vinyl ether-maleic acid copolymer wherein said partial salts contain from about 15% to about 40% free acid and as the cationic salt function: a) from about 0.1% to about 80% strontium cations; and b) from about 0.1% to about 65% zinc cations of the total initial carboxyl groups reacted.
  • US 5,753,723 (Chang & Diferdinando), describes a fixative composition in powder, liquid, cream, film and gel form containing an adhesion promoter and a highly cross-linked derivative of a lower alkyl vinyl ether-maleic anhydride or maleic acid copolymer wherein at least 65% of the total number of carboxyl groups in the copolymer are reacted.
  • the adhesion promoters are chelating agents such as polycarboxylic acids, hydroxcarboxylic acids, aminocarboxylic acids, phosphoric acid and their alkali salts and the like.
  • WO2013/054236 (Procter and Gamble) describes a denture adhesive composition having a denture adhesive component and a cohesion builder component.
  • the cohesion builder component may be salts mono-phosphates, salts of di-phosphates or salts of tri-phosphates and is said to increase the cohesion of the denture adhesive component when hydrated.
  • the compositions are also said to deliver improvements on desirable properties such as long lasting hold, strong hold and / or resistance to dilution / washout.
  • denture adhesive compositions comprise one or more denture adhesive polymers dispersed in a water insoluble component. During use, the moisture in saliva penetrates through the water-insoluble component and hydrates the denture adhesive polymer. This makes the denture adhesive polymer cohesive and sticky to the oral cavity and oral mucosa and denture plate surface.
  • Denture adhesive compositions need to develop a high degree of tack upon contact with saliva so that the dentures can be held in place as soon as they are seated in the mouth. It is also highly desirable that the mucilageneous mass formed on exposure of the denture adhesive composition to moisture in the oral cavity, be spread over the denture-mucosa interface in order to effectively seal the denture in place and that the denture adhesive possesses sufficient cohesive strength to withstand the stresses of mastication which act to rupture the seal and thus dislodge the denture.
  • Cohesive strength is a measure of the strength of the chemical bonds and / or interaction within the adhesive polymers which may result from any of the following:
  • a denture adhesive composition Another important desirable property of a denture adhesive composition is that it provides cushioning for the denture wearer and that salivary washout out of the composition is avoided. Further, the organoleptic properties of the denture adhesive composition, such as mouth feel and consistency should be acceptable to the user and the composition should not be too messy or sticky to apply.
  • the present invention is based upon the unexpected finding that the addition of a bioactive glass to a denture adhesive composition surprisingly results in a superior product, with a greater maximum hold strength and/or a longer hold time with a more preferential patient/user experience as the adhesive adheres faster and in a more cohesive fashion.
  • the bioactive glass appears to interact with the denture adhesive to produce a more efficacious adhesive.
  • the present invention relates to a denture adhesive composition
  • a denture adhesive composition comprising a denture adhesive polymer and a bioactive glass.
  • the present invention relates to the use of a bioactive glass as an adhesion aid and / or a cohesion aid in a denture adhesive composition.
  • the present invention relates to a method for adhering a denture to the mouth of a denture wearer, comprising applying a denture adhesive composition comprising a denture adhesive polymer and a bioactive glass to a denture and placing said denture into the mouth of said denture wearer.
  • Adhesion aid means a material that aids or enhances the adhesive properties of the denture adhesive composition.
  • Cohesion aid means a material that aids or enhances cohesion of the adhesive polymer when hydrated.
  • the cohesive strength of a denture adhesive composition according to the invention is produced rapidly, resulting in a composition that is easy to apply on to a denture surface and, because the cohesive strength is maintained over time, is easy to remove from the denture surface and mouth of a denture wearer.
  • the invention in another aspect, relates to a method of adhering a denture to the oral mucosa by the use of a denture adhesive composition comprising a denture adhesive polymer and a bioactive glass.
  • Bioactive glasses have been disclosed for use in certain oral care applications.
  • WO96/10985 discloses particulate bioactive silica-containing glasses that can reduce pulpal irritation of a tooth and/or strengthen the structure of a tooth and therefore have use in the treatment of hypersensitive teeth. It is suggested that such glasses can consist solely of silicon dioxide or silicon hydroxide or can contain one or more additional elements selected from Ca, P, Na, K, Al, B, N, Mg, Ti or F.
  • W097/27148 discloses particulate bioactive and biocompatible glasses which can remineralize teeth and are of particular use in the reduction of dentin hypersensitivity.
  • a bioactive glass for use in the present invention typically is formed from a combination of silicon dioxide (Si0 2 ), calcium oxide (CaO), sodium oxide (Na 2 0) and phosphorous oxide (P 2 0 5 ) wherein one or more of the preceding oxides may be replaced by one of more of the following: Strontium oxide (SrO); boron trioxide (B 2 0 3 ); potassium oxide (K 2 0); magnesium oxide (MgO); zinc oxide (ZnO); MF X where M is a monovalent or divalent cation and x is 1 or 2.
  • the bioactive glass is formed from a combination of about 40% to about 60% by weight silicon dioxide, from about 10% to about 40% by weight calcium oxide, from about 10% to about 35% by weight sodium oxide, from about 2% to about 8% phosphorus oxide, from about 0% to about 25% by weight calcium fluoride, from about 0% to about 10% by weight boron oxide, from about 0% to about 8% by weight potassium oxide, from about 0% to about 5% magnesium oxide.
  • the bioactive glass comprises about 45% by weight silicon dioxide, about 24.5% by weight sodium oxide, about 6% by weight phosphorus oxide, and about 24.5% by weight calcium oxide.
  • One such bioactive glass is available commercially under the trade name, NovaMin ® , also known as 45S5 Bioglass ® .
  • a bioactive glass for use in the present invention may be prepared by a variety of processes e.g. by melt-derived or sol-gel processes, and may have a variety of compositional elements and ranges.
  • the bioactive glass is present in an amount ranging from about 0.01% to about 10% by weight of the denture adhesive composition.
  • the bioactive glass is present in an amount from about 0.05% to about 8% by weight of the denture adhesive composition.
  • the bioactive glass is present in an amount from about 0.1% to about 6% by weight of the denture adhesive composition.
  • the bioactive glass is present in an amount from about 0.2% to about 5% by weight of the denture adhesive composition.
  • the bioactive glass is present in an amount from about 0.5% to about 2% by weight of the denture adhesive composition.
  • Bioactive glasses for use in denture adhesive compositions of the present invention are in particulate form and may have an average particle size, (as determined by laser diffraction), less than or equal to about 500 ⁇ , suitably less than about 250 ⁇ or less than about 150 ⁇ .
  • small particles are used; for example particles having an average particle size of less than 100 ⁇ , such as in the range of about ⁇ . ⁇ to about 90 ⁇ or about ⁇ . ⁇ to about 25 ⁇ .
  • a denture adhesive compostion of the present invention comprises one or more denture adhesive polymers.
  • Suitable denture adhesive polymers for use in compositions of the present invention have the property of swelling upon exposure to moisture to form a mucilaginous mass.
  • Suitable adhesive polymers are described in WO13/054236 (Procter and Gamble).
  • suitable denture adhesive polymers include at least one of a natural gum, synthetic polymer gum, synthetic polymer, mucoadhesive polymer, hydrophilic polymer, saccharide derivative cellulose and cellulose derivative; or a combination of two or more thereof.
  • Such materials include, but are not limited to: gums such as xanthan gum, locust bean gum, konjac gum, karaya gum, tracaganth gum, guar gum and its derivatives, fenugreek gum; dietary fibres; pectin and its derivatives; chitosan and its derivatives; carrageenan and its derivatives; sodium alginate; and cellulosic polymers such as methylcellulose, carboxymethylcellulose, sodium carboxymethyl cellulose, hydroxethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylcellulose, nitrocellulose and corn starch; or a combination of two or more thereof.
  • gums such as xanthan gum, locust bean gum, konjac gum, karaya gum, tracaganth gum, guar gum and its derivatives, fenugreek gum
  • dietary fibres pectin and its derivatives
  • chitosan and its derivatives carrage
  • Examples of synthetic polymers include, but are not limited to: polyethylene oxide homopolymers or copolymers; polyacrylic acid or polymethacrylic acid homopolymers, copolymers and their derivatives including carbomer and Carbopol ® polymers; copolymers of vinylpyrrolidone and their derivatives; and alkyl vinyl ether-maleic acid or anhydride (AVE/MA) or salts, mixed salts or partial salts, polymeric salts and copolymers thereof; or a combination of two or more thereof.
  • mixed salts refers to salts wherein at least two different cations are mixed on the same polymer with each other or with other salts.
  • partial salts refers to salts of polymers whereon less than 100% of the acid groups are reacted.
  • the denture adhesive polymer for use in a composition of the present invention includes at least one of: : a salt of AVE/MA, mixed salt of AVE/MA, partial salt of AVE/MA, and a polymeric salt and a copolymer thereof or a combination of two or more thereof.
  • the denture adhesive polymer comprises a salt of a polymer of AVE/MA.
  • the denture adhesive polymer comprises a partial salt of a polymer of AVE/MA.
  • the denture adhesive polymer comprises a mixed partial salt of a polymer of AVE/MA.
  • the AVE/MA copolymer contains a cationic salt selected from strontium, zinc, iron, magnesium calcium, sodium or a combination of two or more thereof. In one embodiment the AVE/MA copolymer contains a cationic salt selected from calcium and sodium or a combination thereof.
  • the AVE/MA copolymer will suitably have a molecular weight of at least 900,000 Daltons. In certain embodiments the molecular weight is from about 1,000,000 to about 3,000,000.
  • Examples of a suitable coploymer of alkyl vinyl ether-maleic anhydride (AVE/MA) that are commercially available are sold under the Trade Name Gantrez ® , available from International Specialty Products. These include the Gantrez AN (Anhydride) form such as Gantrez AN169 (a copolymer of methyl vinyl ether/maleic anhydride) and the Gantrez MS form such as Gantrez MS- 955 (a mixed sodium and calcium salt of methyl vinyl ether and maleic anhydride copolymer).
  • Gantrez AN Anhydride
  • Gantrez MS form such as Gantrez MS- 955 (a mixed sodium and calcium salt of methyl vinyl ether and maleic anhydride copolymer).
  • the denture adhesive polymer for use in a composition of the present invention includes at least one of: a cellulose derivative such as methylcellulose, carboxymethylcellulose, sodium carboxymethyl cellulose, hydroxethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylcellulose, nitrocellulose and corn starch; polyethylene glycol/polyethylene oxide; karaya gum; sodium alginate; and chitosan; or a combination of two or more thereof.
  • a cellulose derivative such as methylcellulose, carboxymethylcellulose, sodium carboxymethyl cellulose, hydroxethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylcellulose, nitrocellulose and corn starch
  • polyethylene glycol/polyethylene oxide such as methylcellulose, carboxymethylcellulose, sodium carboxymethyl cellulose, hydroxethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylcellulose, nitrocellulose and corn starch
  • the denture adhesive polymer for use in a composition of the invention includes at least one of methylcellulose, carboxymethylcellulose, sodium carboxymethyl cellulose, hydroxethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylcellulose, nitrocellulose, corn starch or a combination of two or more thereof.
  • the denture adhesive polymer comprises a combination of a copolymer of AVE/MA and a cellulose derivative.
  • a suitable cellulose derivative is sodium carboxymethyl cellulose.
  • An example of a suitable copolymer of alkyl vinyl ether-maleic anhydride (AVE/MA) is sold under the Trade Name Gantrez ® , as described hereinabove.
  • the denture adhesive polymer or a combination of two or more thereof is present in an amount from about 5% by weight to about 99.99% by weight; suitably the adhesive polymer or combination of two or more thereof is present in an amount from about 10% weight to about 90% by weight such as from about 20% to about 80%, from about 30% to about 70% by weight of the denture adhesive composition.
  • the denture adhesive polymer comprises a copolymer of AVE/MA in an amount from about 20% to about 40% by weight of the denture adhesive composition and a cellulose derivative such as sodium carboxymethyl cellulose in an amount from about 20% to about 40% by weight of the denture adhesive composition.
  • denture adhesive compositions of the present invention have shown a significant decrease in the time needed for the denture adhesive composition to fully react and adhere to the denture surface and oral mucosa. This provides more material to create the adhesion because less material is lost through swallowing of some of the denture adhesive, which is known in the art to regularly occur and is unpleasant for a patient/consumer.
  • Denture adhesive compositions of the present invention may be used to secure full or partial dentures.
  • the bioactive glass When applied to partial dentures, the bioactive glass may also act to treat dentinal hypersensitivity of the natural teeth in the mouth.
  • the denture adhesive compositions may be formulated with additional components well known in the denture adhesive art comprising: waxes, oils, preservatives, anti-caking agents, fluoride ions, deodorising agents, anti-microbial agents, humectants, flavouring agents, colorants, sweetening agents, viscosity modifiers, and so forth.
  • the waxes useful in the invention include, but are not limited to, both natural and synthetic waxes and include without limitation animal waxes such as beeswax, lanolin and shellac wax, vegetable waxes such as carnauba, candelilla and bayberry wax, mineral waxes such as cresins waxes, peat waxes, petroleum waxes such as paraffin, and microcrystalline wax and synthetic waxes such as polyethylene waxes.
  • the wax is petrolatum.
  • the denture adhesive composition comprises from about 0% to about 95% by weight of wax, typically about 10% to about 50% by weight of wax.
  • oils useful in the invention include, but are not limited to, mineral oil, vegetable oil such as corn, soybean, cottonseed, castor, palm and coconut oils, mineral oils, animal oil such as fish oil, and oleic acid.
  • the oil is mineral oil.
  • the denture adhesive composition comprises from about 0% to about 95%by weight of oil. In another aspect the denture adhesive composition comprises from about 10% to about 50% by weight of oil.
  • Preservatives which may be used in the denture adhesive compositions of the invention include, but are not limited to, those known antimicrobial agents conventionally employed in the art, such as benzoic acid and sodium benzoate; the parabens; sorbic acid and sorbates; propionic acid and propionates; acetic acid and acetates; nitrates and nitrites; sulfur dioxide and sulfites; antibiotics; diethyl pyrocarbonate; epoxides; hydrogen peroxide; and phosphates.
  • the parabens include the methyl, ethyl, propyl, and butyl esters of parahydroxybenzoic acid. In one aspect, a single preservative may be used.
  • a combination of two or more preservatives may be used.
  • the preservative is methyl paraben.
  • the preservative is propyl paraben.
  • the denture adhesive composition comprises a combination of methyl paraben and propyl paraben as the preservatives.
  • the denture adhesive composition comprises from about 0.03% to about 0.25% by weight of the preservative.
  • Anti-caking agents which may be used in the denture adhesive compositions of the invention include, but are not limited to, silica, magnesium stearate and talc.
  • Suitable sources of fluoride ions for use in the compositions of the present invention include an alkali metal fluoride such as sodium fluoride, an alkali metal monofluorophosphate such a sodium monofluorophosphate, stannous fluoride, or an amine fluoride in an amount to provide from 25 to 3500pm of fluoride ions, preferably from 100 to 1500ppm.
  • a typical fluoride source is sodium fluoride, for example the composition may contain 0.1 to 0.5% by weight of sodium fluoride, eg 0.204% by weight (equating to 927ppm of fluoride ions), 0.2542% by weight (equating to 1150ppm of fluoride ions) or 0.315% by weight (equating to 1426ppm of fluoride ions).
  • composition of the invention may optionally comprise one or more therapeutic actives suitable for mucosal or topical application.
  • therapeutic actives that are useful in the present compositions incliue antimicrobial agents such as iodine , sulphonamides, bisbiguanidines, or phenolics; antibiotics such as tetracycline, neomycin, kanamycin, metroidazole or clindamycin; anti-inflammatory agents such as aspirin, acetaminophen, naproxen and its salts, ibuprofen, ketorolac, flurbiprofen, indomethacin, eugenol or hydrocortisone; dentinal desensitizing agents such as potassium nitrate, potassium chloride, strontium chloride, anaesthetic agents such as lidocaine, antifungals; aromatics such as camphor, eucalyptus oil and aldehydes derivatives such as benzaldehyde, insulin, steroids
  • humectants which may be used in the denture adhesive compositions of the invention include, but are not limited to, polyethylene glycol, propylene glycol and the like or combinations thereof.
  • flavouring agents well known to the denture adhesive art may be added to the compositions of the present invention.
  • These flavouring agents include, but are not limited to, synthetic flavour oils and/or oils derived from plants, leaves, flowers, fruits and so forth, and combinations thereof.
  • Representative flavour oils include spearmint oil, cinnamon oil, oil of wintergreen (methylsalicylate) and peppermint oils.
  • artificial, natural or synthetic fruit flavours such as citrus oil including lemon, orange, grape, lime, and grapefruit, and fruit essences including apple, strawberry, cherry, pineapple, and so forth.
  • the flavouring agent may be a liquid, spray dried, encapsulated, or absorbed on a carrier, and mixtures thereof.
  • the flavouring agent is peppermint oil.
  • the denture adhesive composition comprises from about 0.01% to about 3.0% by weight of the flavouring agent. In another aspect, the denture adhesive composition comprises from about 0.01% to about 2.0% by weight of the flavouring agent. In another aspect, the denture adhesive composition comprises from about 0.05% to 2% by weight of the flavouring agent.
  • the denture adhesive compositions may also include the use of sweeteners well known in the art.
  • the sweetening agent may be selected from a wide range of materials including water-soluble agents, water-soluble artificial sweeteners, and dipeptide based sweeteners, including mixtures thereof.
  • sweeteners include, but are not limited to, (a) sugar alcohols such as sorbitol, xylitol, mannitol, maltitol, hydrogenated starch hydrolysate, and mixtures thereof; (b) water-soluble artificial sweeteners such as the soluble saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate salts, Acesulfame-K, sucralose, and the like, and the free acid form of saccharin; and (c) dipeptide based sweeteners such as L-aspartyl-L-phenylalanine methyl ester, and the like.
  • the denture adhesive composition comprises from about 0.001% to about 5 % by weight of the sweetening agent.
  • the colourants useful in the present invention include the pigments such as titanium dioxide, and may also include dyes suitable for food, drug and cosmetic applications. These colourants are known as FD&C dyes. Illustrative examples include, but are not limited to, D&C ed#30 Aluminium Lake Paste, D&C Red #7 Calcium Lake Paste, Erythrosine Lake Paste, indigo dye, known as FD&C Blue No. 2, which is the disodium salt of 5,5 -indigotindi-sulfonic acid; FD&C Green No.
  • the denture adhesive composition comprises from about 0% to about 0.2% by weight of colourant.
  • the viscosity modifiers useful herein include, but are not limited to, silica, quaternary ammonium compounds and similar agents, starches, gums, casein, gelatin and semi-synthetic cellulose.
  • the denture adhesive compositions may be in the form of a powder, a paste, a gel, a cream, a strip or a denture liner. In one aspect, the denture adhesive composition is in the form of a paste. In another aspect, the denture adhesive composition is in the form of a cream. Means for preparing such compositions are well known in the denture adhesive art, employing conventional types of mixing equipment for blending, heating, and cooling solids and liquids. In one embodiment, mixing is performed at temperatures suitable to melt the components, e.g. petrolatum, to be blended.
  • the components are admixed with flavouring agents and colorants, together with other ingredients such as non-toxic anti-caking agents (silica, magnesium stearate, talc and the like).
  • the mixture of ingredients is thoroughly agitated or stirred to yield a completely homogenous intermixing of all components.
  • the components are admixed with petrolatum along with the previously described waxes, oils, preservatives, flavouring agents, colorants, sweetening agents, viscosity modifiers, and so forth.
  • the components are uniformly mixed and then coated onto a non- adhesive self supporting coating layer by any conventional coating techniques, such as by spraying, (if the material is liquid or slurry or dissolved or suspended in a liquid such as water), or by sifting, (if the denture adhesive is in powder form).
  • the components are admixed with the previously described waxes, oils, preservatives, flavouring agents, colorants, sweetening agents, viscosity modifiers, and so forth.
  • the liner is then formed by any variety of techniques known in the polymer film-forming art, including casting, calendaring, coating, and extrusion.
  • the components are first mechanically softened by a ring roller; smoothed on a hydraulic press, and die-cut as desired into denture liner shapes or other desired shapes.
  • Denture adhesive compositions were prepared according to Table 1 and Table 2 below.
  • the appropriate amount of mineral oil and petrolatum were added together in a container and mixed using a speed mixer (DAC 400.1 fvz) for two minutes at 2700 rpm.
  • the appropriate amount of powdered sodium carboxymethyl cellulose, Poly(methylvinyether/melaic acid) Na/Ca mixed partial salt (GantrezTM) and bioactive glass were added together in a separate container and mixed gently.
  • the powders were then added to the mineral oil and petrolatum mixture and mixed using a speed mixer for another two minutes at 2700 rpm. Finally, the mixture was mixed for a further 4 minutes using a speed mixer at 2700 rpm.
  • Formulations 1 and 6 are included for comparative purposes only and are not exemplifications of the invention.
  • Bioactive glass (average particle size
  • Bioactive glass average particle size 2 16 ⁇
  • Bioactive glass (average particle size
  • Bioactive glass (average particle size
  • Bioactive glass (average particle size
  • Bioactive glass (average particle size
  • Bioactive glass (average particle size
  • T* approximate max hold time, up to 10 lb force.
  • T* approximate max hold time, up to 10 lb force.
  • Bioactive glass (average particle size 7.5 ⁇ ) 5.00
  • Bioactive glass (average particle size 23 ⁇ ) 1
  • T* approximate max hold time, up to 10 lb force.
  • Formulations 1 and 3 are as shown in Table 1.

Abstract

La présente invention concerne des compositions adhésives pour prothèse dentaire comprenant un polymère adhésif pour prothèse dentaire et un verre bioactif, ainsi que l'utilisation et des procédés de fabrication de telles compositions.
PCT/EP2015/078625 2014-12-08 2015-12-04 Adhésif pour prothèse dentaire WO2016091738A1 (fr)

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Application Number Priority Date Filing Date Title
GB1421744.2 2014-12-08
GBGB1421744.2A GB201421744D0 (en) 2014-12-08 2014-12-08 Denture adhesive composition

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4299048A1 (fr) 2022-06-30 2024-01-03 GlaxoSmithKline Consumer Healthcare (UK) IP Limited Adhésif pour prothèse

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017965A2 (fr) * 1990-05-18 1991-11-28 University Of Florida Compositions sol-gel bioactives et depourvues d'alcalis
US20040115240A1 (en) * 2001-03-16 2004-06-17 Timo Narhi Composite for attaching, growing and/or repairing of living tissues and use of said composite
US20120020899A1 (en) * 2009-04-01 2012-01-26 Colgate-Palmolive Company Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof
WO2013054236A1 (fr) * 2011-10-12 2013-04-18 The Procter & Gamble Company Compositions de ciment pour prothèse dentaire

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017965A2 (fr) * 1990-05-18 1991-11-28 University Of Florida Compositions sol-gel bioactives et depourvues d'alcalis
US20040115240A1 (en) * 2001-03-16 2004-06-17 Timo Narhi Composite for attaching, growing and/or repairing of living tissues and use of said composite
US20120020899A1 (en) * 2009-04-01 2012-01-26 Colgate-Palmolive Company Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof
WO2013054236A1 (fr) * 2011-10-12 2013-04-18 The Procter & Gamble Company Compositions de ciment pour prothèse dentaire

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4299048A1 (fr) 2022-06-30 2024-01-03 GlaxoSmithKline Consumer Healthcare (UK) IP Limited Adhésif pour prothèse
WO2024003122A1 (fr) 2022-06-30 2024-01-04 Glaxosmithkline Consumer Healthcare (Uk) Ip Limited Adhésif pour prothèse dentaire

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