MXPA99011830A - Denture adhesive comprising a polymeric activator and methods of preparing the same - Google Patents

Abstract

Se expone una composición de adhesivo para dentadura que comprende un activador polimérico en una cantidad de hasta 3 por ciento en peso, con base en el peso total de la composición de adhesivo para dentadura. Esta composición exhibe características adhesivas mejoradas y reduce el enlamado e incidencia de oclusiones por alimento. También se expone un método para preparar una composición de adhesivo para dentadura, que consiste en preparar una mezcla que comprende un activador polimérico en una cantidad de hasta aproximadamente 3 por ciento en peso, con base en el peso total de la composición de adhesivo para dentadura;formar una composición de adhesivo para dentadura que incluye la mezcla y recuperar la composición de adhesivo para dentadura. También se expone un método para elaborar una composición de adhesivo para dentadura que es más adhesiva y forma menos lama. Este método consiste en adicionar a la composición de adhesivo un activador polimérico en una cantidad de hasta aproximadamente 3 por ciento en peso, con base en el peso total de la composición de adhesivo para dentadura.

Description

ADHESIVE FOR DENTURE THAT COMPRISES A POLYMERIC ACTIVATOR AND METHODS TO PREPARE THE SAME BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to denture adhesives containing a polymeric activator, for example polymeric acid, and to methods for improving the denture adhesive product by adding it to a polymeric activator. 2. Description of Related Art Dentures are substitutes for missing teeth and serve as a replacement for all or some of the teeth found in the oral cavity.

Despite diligent efforts on the part of dentists and denture designers and denture designers, dentures do not always fit perfectly. Over time, even well-fitting dentures can result in an imperfect fit due to shrinkage and natural changes in the gums or mucosal tissues. Therefore, creams, liquids or adherent powders are usually used to secure the dentures inside the mouth. There are many desirable characteristics in P1723 / 99MX a composition for fixing dentures. An extremely desirable attribute is that it develops a high degree of stickiness on contact with saliva, so that the denture can be held in place as soon as it is seated in the mouth. It is also greatly desired that the mucilage be dispersed over the denture-mucosal interface in order to effectively seal the denture in place and that the mucilages possess sufficient cohesive force to withstand the masticatory stresses that act to break the seal and therefore dislodge the denture. The denture fixator should always exhibit sufficient resistance to degradation under extreme environmental changes that occur in the oral cavity during common actions such as drinking coffee or other hot beverages. Of course, the adhesive must always be releasable so that the user of the denture can remove the denture for cleaning and maintenance. Denture adhesives are generally sold as creams, coatings or strips, they are liquids or powders, and many examples are well known in the art. The first denture adhesives contained finely ground particles of natural gums that expanded when wetted with water to form a viscous gel, which then acted as a cushion and an adherent between the plaque of the P1723 / 99MX denture and gum tissue. These denture adhesives have tended to be supplanted by polymeric denture adhesives. U.S. Patent No. 3,003,988, for example, discloses a dental setting composition wherein the dental fixator is a mixed partial salt containing calcium cations and quaternary ammonium or alkali cations or a vinyl ether-lower alkyl type copolymer. maleic anhydride. The mixed salt copolymer is insoluble in water but is a water-sensitive copolymer. U.S. Patent No. 3,736,274 shows a dental fixation composition containing a polymeric material of lower alkyl vinyl ether-maleic anhydride, a polymeric N-vinyl lactam and a sodium carboxymethyl cellulose. The carboxymethyl cellulose prevents the complex of the lower alkyl vinyl ether copolymer maleic anhydride and the N-vinyl lactam from being completely precipitated when placed in water. U.S. Patent No. 3,868,432 shows an anhydrous, denture adhesive composition, which is a mixture of a copolymer of an acrylamide and an anionic synthetic rubber component, which may be a copolymer of maleic acid with vinyl lower alkyl vinyl ether . United States Patent No.

P1723 / 99MX 4,373,036 discloses a denture fixing composition containing hydroxypropylcellulose and an optionally crosslinked, partially neutralized polyacrylic acid or a precursor combination thereof or partially neutralized copolymers of maleic acid or anhydride and alkyl vinyl ethers which are optionally partially crosslinked, or a combination thereof, and / or polyethylene oxide. United States Patent No.

No. 4,521,551 discloses a denture fixing composition containing denture-fixing excipients and as the denture fixative, a copolymer of anhydride or maleic acid and partially neutralized water-soluble alkyl vinyl ether, the copolymer is optionally partially cross-linked with a compound of polyhydroxyl, and at least one hydrophilic polymer, preferably sodium carboxymethylcellulose, polyethylene oxide or hydroxypropyl sugar. U.S. Patent No. 4,758,630 discloses denture adhesives comprising partial salts of zinc and strontium of vinyl ether-lower alkyl-maleic acid copolymers, wherein the zinc and strontium cations are not mixed with other cations or groups of ester function in the copolymer salt, the remainder of the initial carboxyl group remains unreacted.

P1723 / 99MX U.S. Patent No. 5,006,571 discloses denture adhesives comprising a substantially anhydrous mixture of a mixed Na / Ca salt of methyl vinyl ether maleic acid, sodium carboxymethylcellulose and a trivalent cation. Aluminum and sodium dihydroxy carbonate can be the source of the trivalent cation. The sodium aluminum dihydroxycarbonate can be the source of the trivalent cation, in which case a food grade acid must be added to help release the aluminum from the composition. Acids for example include citric acid, maleic acid, tartaric acid and fumaric acid. The acid may comprise up to about 4 weight percent of a denture adhesive composition. Additionally, benzoic acid or sorbic acid can be included in the denture adhesive as a preservative. U.S. Patent No. 5,525,652 and No. 5,830,933 disclose the use of mixed salts of copolymeric acid in the formulation of denture adhesive compositions. Preferably, the salts are mixed salts of Ca / Na or Ca / K, and more preferably are partial salts of Zn / Mg and salts Na / Zn / Mg. The exhibition of each of these is incorporated here as a reference. U.S. Patent No. 5,093,387 also teaches that benzoic acid and P1723 / 99MX sorbic acid can be used as preservatives in denture adhesive formulations in amounts of about 0.03 to about 0.6 weight percent of the total denture adhesive composition. Each of these adhesive materials discussed above has certain advantages and disadvantages when compared to other denture adhesives. The search for better adhesive materials for dentures continues and denture adhesives with better grip, with longer hold and with better organoleptic properties are always desirable.

SUMMARY OF THE INVENTION It is an object of this invention to provide novel and improved denture fasteners exhibiting a reinforced adhesive feature and lower exudation and lower incidence of food occlusion. These and other objects of the invention will become apparent to those skilled in the art from the following detailed description. The present invention provides a denture adhesive composition comprising a polymeric activator in an amount of up to about 3 weight percent based on the total weight of the adhesive composition for P1723 / 99MX denture. The present invention further provides a method for preparing a denture adhesive composition comprising: preparing a mixture comprising a polymeric activator in an amount of up to about 3 weight percent based on the total weight of the denture adhesive composition; forming a denture adhesive composition that includes the mixture, and recovering the denture adhesive composition. The present invention further provides a method for making a denture adhesive composition that is more adhesive and less tending to exude, which comprises adding to the denture adhesive composition a polymeric activator in an amount of up to about 3 weight percent with based on the total weight of the denture adhesive composition.

DETAILED DESCRIPTION OF THE INVENTION A novel denture adhesive base composition was described which surprisingly performs well. Specifically, the denture adhesives of this invention reduce exudation, improve adhesive characteristics, reduce the incidence of occlusion by food and provide the consumer with greater confidence in the function of the product.

P1723 / 99MX The denture fixing compositions of the present invention can be formulated in powder, liquid and creams which, upon contact with saliva, develop a high degree of stickiness and uniform viscous mucilages of high cohesive strength and which, when dispersed over the denture-mucosa interface, provide better stabilizing properties of the denture. The compositions contain a denture fixator together with an excipient. Typical excipients include waxes and oils. Other materials that are normally included in denture adhesives include flavoring agents, sweetening agents, viscosity modifiers, coloring agents, preservatives and thickeners. Other water-soluble polymers such as for example xanthan gum, polyvinylpyrrolidone (PVP), carboxymethylcellulose, methylcellulose and hydroxypropyl guar can also be part of the final adhesive formulation for the denture. Vehicles such as petrolatum, mineral oil, vegetable oil and the like may be part of the cream-type formulations, and non-toxic anti-clods such as silica, talcum, anhydrous dicalcium phosphate and the like may be present. The compositions may also contain, if desired, other known denture fixatives. While any P1723 / 99MX known denture adhesive, the preferred denture adhesive employed in the composition is a partial salt of a maleic acid or maleic anhydride copolymer and an alkyl vinyl ether. Preferably, the alkyl group has from about 1 to about 5 carbon atoms, but more preferably the copolymer includes methyl vinyl ether. As is known to those skilled in the art, the molecular weight of these copolymers can affect the properties of the copolymer and, by extension, the denture adhesive comprising the copolymer. Polymers generally do not have a precise molecular weight. In contrast, polymers are made up of many polymer molecules, each having different molecular weights. One way to measure the "average" molecular weight of a polymer is to measure its specific viscosity under specific conditions. The preferred copolymer of the invention generally has a specific viscosity (measured as a 1% w / v solution of methyl ethyl ketone at 25 ° C) of at least about 1.5. More preferably, the specific viscosity is at least about 2.5. The preferred copolymer of the invention is generally used as its partial salt. The maleic anhydride group can be hydrolyzed to form the corresponding dicarboxylic acid which, in turn, P1723 / 99MX can react metal compounds that partially neutralize the carboxylic acid groups in the copolymer. Preferably less than 100% of the carboxylic acid groups in the copolymer chain are neutralized. More preferably, the metal compounds neutralize from about 50% to about 90% of the carboxylic acid groups of the copolymer and, more preferably, from about 65% to about 75% of the carboxylic acid groups. Preferred alkali cations include sodium, zinc, potassium, calcium and magnesium. Preferably the salts are simple or mixed salts of calcium, sodium, potassium, magnesium, zinc and zirconium. Preferred mixed salts of two cations ("double salts") include calcium / sodium, calcium / magnesium, calcium / zinc, sodium / zinc, potassium / zinc, sodium / magnesium, potassium / magnesium or calcium / potassium, and more preferably they are partial salts of zinc / magnesium. The "triple salts" of three cations include calcium / sodium / zinc and sodium / zinc / magnesium. A further description of the preferred adhesives can be found in the aforementioned US Patents 5,525,652 and 5,830,933. In general, the adhesive active material will be from about 15 to 60%, preferably from about 25 to 55% of the composition.

P1723 / 99MX The oils useful in the invention include, without limitation, mineral oil, vegetable oil such as corn oil, soybean, cottonseed, castor, palm and coconut and animal oil as fish oil. In general, oil amounts of between about 1% and about 30% by weight of the total denture adhesive composition are useful, with amounts ranging from about 10% to about 25% being preferred. When a mineral oil vehicle is employed, polyethylene can optionally be used as a gelling agent to provide a "synthetic petrolatum" vehicle and, therefore, is used to adjust the extrusion properties of the finished composition. The polyisobutylene can also be used together with the polyethylene to further strengthen the viscosity properties of the vehicle. Alternatively, a petrolatum that is used as a raw material, with or without mineral oil, may be used depending on the specific handling qualities desired for the final product. A particularly preferred combination involves the use of petrolatum in amounts of about 10% to 40% and a heavy or light mineral oil in amounts of about 5% to about 30% by weight of the denture adhesive composition, in order to have a P1723 / 99MX easy extrusion formulation that has a cream-like consistency. A more preferred combination involves the use of petrolatum in amounts of about 20% to 30%, and a light or heavy mineral oil in amounts of between about 10% to 20% by weight of the denture adhesive composition. Waxes can be added to the petrolatum, either during the preparation of the denture adhesive or to form a petrolatum premix. These waxes may be natural or they may be synthetic waxes, including, but not limited to, microcrystalline waxes. When used, amounts in general from about 1% to about 25% by weight of the total denture adhesive composition are useful, with amounts between about 10% to about 25% being preferred. Dyes useful in the present invention include pigments such as titanium dioxide and may also include dye lacquers suitable for food, drugs and cosmetics. These dyes are known as D &C dyes. Preferred dyes are the Red D &C No. 7 and Red D &C No. 30 lacquers. The fumed silica can also be used as a thickener for the adhesive. A fine white powdery fumed silica is the colloidal form of P1723 / 99MX the silica (silicon dioxide, SIO2) produced by the combustion of silicon tetrachloride in a hydrogen-oxygen furnace. The amount of fumed silica used in the composition can vary from about 0.7% to about 2%. The amount is important since it was found that at more than 2% the viscosity increases to such an extent that the cream adhesive becomes very difficult to extrude from the tube and the stability of the cream becomes a problem at elevated temperatures. The dental adhesive compositions of the present invention may further comprise a water soluble cellulosic polymer as is known in the art, for example methyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxy propyl methyl cellulose and the like. The cellulosic polymer, preferably sodium carboxymethyl cellulose, is a powder which, when moistened, becomes hydrated and sticky or gummy, thus providing an additional adhesive feature in the dental adhesive composition. Carboxymethyl cellulose gums are long-chain, anionic, water-soluble polymers whose properties vary to a certain degree depending on the number of carboxymethyl groups that are substituted by the anhydro-glucose unit in each cellulose molecule. These cellulose polymers comprise from about 15% to about 35%, and, preferably, from P1723./99MX about 17% to about 28% of the dental adhesive composition. The activator in the invention is a polymeric activator. Although the term "polymeric" normally means a material having hundreds or even thousands of repeating monomer units, the thermal polymeric as used herein encompasses materials comprising seven carbon atoms and materials having a carbon "basic structure" of In this way, citric acid, for example, citric acid, which is not a polymer and has six carbon atoms and a "basic structure" of five carbon atoms (including carboxylic acid groups) is not within the scope of the invention Preferably, the activator comprises more traditional polymers, including relatively short chain resins and longer polymers, copolymers, block or graft copolymers and network or linear polymers These materials can occur in nature or derive from it or be totally artificial. Preferred include salts and polymeric chelating acids. Preferred chelating salts and acids comprise copolymers of dicarboxylic materials such as methyl vinyl ether / maleic anhydride copolymers and acrylic acid / maleic acid copolymers.

P1723 / 99MX A preferred polymeric activator is a salt or polymeric acid, for example a vinyl ether-lower alkyl-maleic acid copolymer. This polymeric acid consists essentially of the following repeated structural unit: OR - CH, - CH CH CH - C02H C02H wherein R represents an alkyl radical of 1 to 4 carbon atoms, preferably methyl. The lower alkyl vinyl ether-maleic acid polymers are easily obtained by the polymerization of a lower alkyl vinyl ether monomer, for example methyl vinyl ether, ethyl vinyl ether, divinyl ether, propyl vinyl ether and isobutyl vinyl ether, with anhydride maleic to give the corresponding lower alkyl vinyl ether-maleic anhydride polymer which is easily hydrolysable in the acidic polymer. Both forms of anhydride and acid are also available from commercial suppliers. For example, the ISP Corporation provides both the free form of the polymeric acid and the corresponding anhydride form under its "GANTREZ" brand as the "GANTREZ S Series" and the "GANTREZ AN Series", respectively. Daicel also provides an anhydrous form under the brand name "VEMA". GANTREZ S-97 acid is particularly suitable. When the anhydride polymer is dissolved in water, the anhydride bond is broken so that the highly polar polymeric free acid is formed. Consequently, the anhydride form, which is relatively less expensive than the acid form, may be used as a convenient and cheaper acid precursor. It may be advantageous to use elevated temperatures to improve the hydrolysis rate of anhydride to acid. Surprisingly, we have not been able to show that some other polymeric acids work well for the invention. For example, alginic acid (or a salt thereof) also known as polymannuronic acid, does not appear to offer the benefits of the invention. Alginic acid is obtained commercially and is a linear polymer of residues of a- (1-4) -D-mannosyluronic acid and a- (1-4) -L-gulosiluronic acid; the relative proportion of which varies with the botanical source and the state of maturation of the plant. However, other acid or acid salt additives in denture adhesives, for example sodium carboxymethyl cellulose ("CMC"), do not appear to act as activators within the invention. Consequently, non-chelating polyacrylic acids such as Carbopol would not be expected to work for the invention. The preferred salt cations for P1723 / 99MX activators include non-toxic cations, preferably sodium or potassium cations. In a modality, this invention provides a denture adhesive composition comprising a polymeric activator in an amount of up to about three percent by weight based on the total weight of the denture adhesive composition. In the absence of the polymeric activator from the composition of this invention, the compositions can be prepared so as not to exhibit the improved effect achieved of the composition of the present invention. This is a surprising result because the denture adhesives may already contain polymeric acid salts as part of the partial salt, as already mentioned. The denture adhesive of the invention exhibits only the improved effect when the free polymeric activator is added. Preferably, the polymeric activator is present in an amount of up to about 3% by weight based on the total weight of the denture adhesive composition. More preferably, the polymeric acid is present in an amount of about 0.1 to about 1.5 weight percent, and more preferably about 1 weight percent based on the total weight of the denture adhesive composition. In a preferred embodiment of the invention, P1723 / 99MX The denture adhesive composition comprises the Mg / Zn / Na or Ca / Na or Ca / Zn salt of a vinyl ether-lower alkyl-maleic acid copolymer, where the lower alkyl vinyl ether-maleic acid it is present in an amount of up to about 3 weight percent based on the total weight of the denture adhesive composition. More preferably, the lower alkyl vinyl maleic acid is present in an amount of about 0.1 percent to about 1.5 percent, and more preferably about 1 percent by weight based on the total weight of the composition of the composition. denture adhesive, and the lower alkyl groups are methyl. Other preferred copolymers include copolymers of acrylic acid and maleic acid or maleic anhydride. The invention also provides a method for preparing a denture adhesive composition comprising: preparing a mixture comprising a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition; forming a denture adhesive composition that includes the mixture; and recovering the denture adhesive composition. Preferably, the polymer activator is present in an amount of about 0.1 per P1723 / 99MX cent to about 1.5 weight percent based on the total weight of the denture adhesive composition being prepared. More preferably, the polymer activator is present in an amount of about 1 percent by weight based on the total weight of the denture adhesive composition being prepared. The invention further provides a method for preparing a denture adhesive composition comprising: preparing a mixture comprising either the Mg / Zn / Na or Ca / Na salt or the Ca / Zn partial salt of a mixed vinyl ether salt of lower alkyl-maleic acid and lower alkyl vinyl ether-maleic acid, wherein the lower alkyl vinyl-maleic acid is present in an amount of up to about 3 weight percent based on the total weight of the adhesive composition for denture, forming a denture adhesive composition that includes the mixture, and recovering the denture adhesive composition. Preferably, the lower alkyl vinyl-maleic acid vinyl is present in an amount from about 0.1 percent to about 1.5 percent by weight based on the total weight of the denture adhesive composition. More preferably, the lower alkyl vinyl maleic acid is present in an amount of about 1 weight percent based on the P1723 / 99MX total weight of the denture adhesive composition. The method for preparing the denture adhesive compositions can be conveniently carried out by mixing the components until a homogeneous mixture is obtained and the resulting product is recovered. Preferably, the base composition is prepared as a pre-mixed formulation that can be mixed with the remaining components used to prepare the final formulation. The mixing is conveniently carried out at suitable temperatures to melt the components to be mixed. For example, if polyethylene and mineral oil are to be used, this material can be heated to temperatures of about 90 ° C to 95 ° C and, preferably, cooled before being mixed with other components, such as polymeric acid and coloring agents . The present invention also provides a method for making a denture adhesive composition that is more adhesive and produces less exudation, which comprises adding to the denture adhesive composition a polymeric activator in an amount of up to about 3 weight percent based on in the total weight of the denture adhesive base. The polymer activator is optionally a finely divided powder. Preferably, the polymer activator is P1723 / 99MX adds in an amount from about 0.1 percent to about 1.5 percent based on the total weight of the denture adhesive composition. More preferably, the polymeric acid is added in an amount of about 1 weight percent based on the total weight of the denture adhesive composition. Optionally, the base composition for adhesive to which the polymeric activator is added comprises a mixed partial salt of a polymeric chelating acid. The mixed salt may be a double salt such as for example Ca / Na salt or a triple salt such as for example lower alkyl vinyl ether salt-maleic acid Mg / Zn / Na. Regardless of whether it is formulated as a powder, liquid or cream, the denture adhesive compositions of this invention are hydrated to form adhesive compositions when applied to moistened or water-exposed dentures. In order to further illustrate the present invention, several examples are set forth below. In these examples as well as throughout the specification and the claims, all parts and percentages are given by weight and all temperatures in degrees Celsius unless otherwise specified.

P1723 / 99MX EXAMPLE 1. This example demonstrates the preparation of a denture adhesive formulation, according to the present invention. The cream-type denture adhesive was prepared by mixing the following ingredients in a Hobart type mixer: The fumed silica was gradually added to a petrolatum dispersion in mineral oil at 70 ° C. Once the fuming silica was uniformly dispersed, the GANTREZ salt was slowly added to the mixture, followed by sodium carboxymethyl cellulose. Once the GANTREZ salt and carboxymethyl cellulose P1723 / 99MX sodium had been completely mixed, the temperature of the mixture decreased to 65 ° C and the dyes were added after GANTREZ S-97 acid (vinyl ether polymer of lower alkyl-maleic acid). The adhesive was mixed for an additional 30 minutes and then cooled to room temperature and discharged. The mixed partial salt was prepared in the following manner. 900.40 grams of purified water at room temperature were charged into a main reaction pot equipped with a high-speed stirrer. 76.26 grams of anhydrous MVE / MA copolymer were added to the main mixing pot, with continuous mixing. 250.11 grams of purified water at room temperature were loaded into a secondary pot and 3.91 grams of NaOH; 15.89 grams of ZnO and 3.94 grams of MgO were added slowly. All inorganic materials used as ingredients in these examples are NF or USP grade anhydrous raw materials, unless otherwise stated. The secondary pot mixed well to form a homogeneous paste. The paste was added to the main reaction vessel while mixing, then the reaction temperature was raised to 85-90 ° C and maintained at that temperature for two hours. The resulting dispersion was cooled to room temperature and poured onto shallow, stainless steel drying trays, and the trays were placed in a hot air convection oven P1723 / 99MX at 70 ° C for 18 to 20 hours to provide a dry salt. Although trays were used in this example, it is also acceptable to use a drum type dryer. The dried Gantrez Mg / Zn / Na salt was subsequently milled in a suitable mill and passed through a # 100 mesh screen. A solution of one percent of the resulting powder would have a pH of between about 5 to about 7. This salt is a 10% Na / 40% Zn / 20% Mg salt of the MVE / MA copolymer.

EXAMPLE 2 (Comparative) A cream adhesive was prepared exactly as shown in Example 1, except that the addition of GANTREZ S-97 Acid was omitted. When tested, the denture adhesive formulations prepared with Example 1 provided a better adhesive characteristic, lower exudation and lower incidence of food occlusion on the denture adhesive formulation of Example 2.

EXAMPLE 3. A cream adhesive was prepared exactly as shown in Example 1, except that Sokalan C5 is used in place of GANTREZ S-97 Acid.

P1723 / 99MX EXAMPLE 4_ A cream adhesive was prepared exactly as shown in Example 1 except that it contains 0.5% GANTREZ S-97 Acid. While examples of specific materials, compositions and processes have been described and illustrated, it will be apparent to those skilled in the art that a wide variety of changes can be made without departing from the broader aspects of the invention. It is understood that the particular examples and proportions and methods of procedure set forth herein are intended to be illustrative only.

P1723 / 99MX

Claims (15)

1. NOVELTY OF THE INVENTION Having described the present invention, it is considered as a novelty and, therefore, the content of the following claims is claimed as property. 1. A denture adhesive composition comprising an effective amount of denture adhesive. comprising a mixture of a polymeric denture adhesive salt and a water soluble cellulosic polymer, and a pharmaceutically acceptable carrier thereof and a free polymeric activator in an amount of up to about 3 weight percent based on the total weight of the denture adhesive composition, wherein the polymeric activator is an acid, or a sodium salt thereof, of a polymer containing a repeating unit having at least seven carbon atoms and more than three carbon atoms in its basic structure, and the activator is not equal to any of the components of the denture adhesive. The denture adhesive composition of claim 1, wherein the polymeric activator is a vinyl ether-lower alkyl-maleic acid copolymer or the sodium partial salt thereof. 3. The denture adhesive composition according to claim 2, wherein the P1723 / 99MX polymer activator is present in an amount from about 0.1 percent to about 1.5 percent by weight based on the total weight of the denture adhesive composition and the polymeric activator is an acid. The denture adhesive composition according to claim 3, wherein the polymeric denture adhesive salt is a mixed partial salt of a maleic acid copolymer and an alkyl vinyl ether and at least one cation, wherein all the Cations are selected from the group consisting of sodium, potassium, calcium, magnesium, zinc and zirconium cations. 5. The denture adhesive composition according to claim 4, wherein one of the cations is a sodium cation and the alkyl entity is methyl. The denture adhesive composition according to claim 5, wherein the denture adhesive comprises a mixture of cayoxymethyl cellulose or the sodium salt thereof and a mixed partial salt of a maleic acid or maleic anhydride copolymer and a vinyl alkyl ether, selected from the group consisting of: mixed partial salt of calcium and zinc, mixed partial salt of sodium and calcium and mixed partial salt of sodium, magnesium and zinc. 7. An adhesive composition for P1723 / 99MX denture consisting essentially of an effective amount of denture adhesive comprising a mixture of a polymeric denture adhesive salt and a water soluble cellulosic polymer, and a pharmaceutically acceptable carrier therefor and an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition of a free polymer activator, which is a partial potassium salt of a polymer containing a repeating unit having at least seven carbon atoms and more of three carbon atoms in its basic structure, and where the activator is not equal to any of the components of the denture adhesive. 8. A method for preparing a denture adhesive composition comprising: (a) preparing a mixture comprising a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition , wherein the polymer activator is an acid of a polymer, or a partial salt of sodium or potassium, of a polymer having a repeating unit having at least seven carbon atoms and more than three carbon atoms in its structure basic, and where the activator is not equal to any of the components of the denture adhesive; P1723 / 99MX (b) forming a denture adhesive composition including the mixture and a denture adhesive comprising a mixture of a polymeric denture adhesive salt and a water soluble cellulosic polymer; and (c) recovering the denture adhesive composition. The method according to claim 8, wherein the polymer activator is vinyl ether copolymer of lower alkyl-maleic acid or a partial salt of sodium thereof. The method according to claim 9, wherein the polymer activator is present in an amount from about 0.1 percent to about 1.5 percent by weight based on the total weight of the denture adhesive composition and the polymer activator is vinyl ether. of lower alkyl-maleic acid. The method according to claim 10, wherein the polymeric denture adhesive salt is a mixed partial salt of a copolymer of maleic acid and an alkyl vinyl ether and at least one cation, wherein all cations are selected from the group consisting of group consisting of sodium, potassium, calcium, magnesium, zinc and zirconium. 12. A method for making a denture adhesive composition comprising a denture adhesive consisting of a mixture of a salt P1723 / 99MX polymeric denture adhesive and a water soluble cellulosic polymer, which has properties of higher adhesion and lower exudation, which comprises adding to the denture adhesive composition a polymeric activator in an amount of up to about 3 weight percent based on the total weight of the denture adhesive composition, wherein the polymeric activator is an acid or a partial salt of sodium or potassium thereof, of a polymer having repeating units containing at least seven carbon atoms and more than three carbon atoms in its basic structure, and wherein the activator is not equal to any of the components of the denture adhesive. The method according to claim 12, wherein the polymer activator is a copolymer of vinyl ether of lower alkyl-maleic acid or the partial salt of sodium thereof. The method according to claim 13, wherein the polymer activator is added in an amount from about 0.1 percent to about 1.5 percent by weight based on the total weight of the denture adhesive composition and the polymer activator is a vinyl lower alkyl ether maleic acid. 15. The method according to claim 14, wherein the denture adhesive comprises a mixture of carboxymethyl cellulose or the sodium salt of the P1723 / 99 X and a mixed partial salt of a maleic or anhydrous maleic acid copolymer and an alkyl vinyl ether, selected from the group consisting of mixed partial salt of calcium and zinc, mixed partial salt of sodium and calcium and partial salt mixed sodium, magnesium and zinc. P1723 / 99MX