WO2016086995A1 - Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire - Google Patents

Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire Download PDF

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Publication number
WO2016086995A1
WO2016086995A1 PCT/EP2014/076541 EP2014076541W WO2016086995A1 WO 2016086995 A1 WO2016086995 A1 WO 2016086995A1 EP 2014076541 W EP2014076541 W EP 2014076541W WO 2016086995 A1 WO2016086995 A1 WO 2016086995A1
Authority
WO
WIPO (PCT)
Prior art keywords
appliance
program module
app
image
ptm
Prior art date
Application number
PCT/EP2014/076541
Other languages
English (en)
Inventor
Michael Kaelbling
Original Assignee
Siemens Healthcare Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Gmbh filed Critical Siemens Healthcare Gmbh
Priority to PCT/EP2014/076541 priority Critical patent/WO2016086995A1/fr
Publication of WO2016086995A1 publication Critical patent/WO2016086995A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0064—Body surface scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/40—Analysis of texture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30068—Mammography; Breast

Definitions

  • the invention refers to an appliance for detecting cancerous or noncancerous lumps in tissues of living beings, in partic ⁇ ular a lump in a mamma, according to claim 1.
  • Detecting cancerous or noncancerous lumps in tissues of liv ⁇ ing beings, in particular the lump in the mamma or breast encompasses any kind or variety of a classical sign of in ⁇ flammation of the tissue such as tumors or adipose tumors. Such a swelling can not only be observed on a human body but also on the body of animals.
  • the main idea of the invention for detecting cancerous or noncancerous lumps in tissues of living beings, in particular a lump in a mamma or breast, according to the claim 1 is to combine techniques and technologies of "Polynomial Texture Mapping ( PTM) "-Analysis and automated surface image capture with the approach of surface displacement, pattern analysis, and wave propagation through differentiated physical media, which allows the production of an appliance for increasing the coverage and acceptance of accurate breast examinations. If suspicious lumps are identified, then referral can be made to more advanced techniques.
  • PTM Polynomial Texture Mapping
  • a Hardware Component including at least one opto ⁇ mechanical Scan-Element and at least one opto-mechanical Im- age-Capture-Element as well as a Data-Interface and a Con ⁇ trol-Interface, which are connected to the Elements, and a microcontroller with a processor and a the processor-assigned storage media as well as a "Polynomial Texture Mapping
  • One or more images are taken for each lighting position, and the "Polynomial Texture Mapping (PTM)" is computed.
  • the created models can be saved, transmitted, and analyzed on-site, off-site, in real time, or on-demand.
  • Recorded mod ⁇ els can show the development of anomalies over time - or in ⁇ dicate the locations and increase or reductions of lumps.
  • Known and novel algorithms for determining appropriate en- hancement settings can be applied (cf. claim 12) .
  • the Hardware Component basically consists of a dome contain ⁇ ing a fixed camera and a large number of controllable light sources (LEDs, fiber-optic, mirrors, flash-bulbs, etc.). Alternatively a reduced number (one or more) of movable light sources can be used.
  • Several domes are possible to at least one of accommodate subject variation, allow tests under pres ⁇ sure or vacuum - i.e. at controlled air or fluid pressures - and allow automated introduction of low-energy waves - e.g. sound or air-jet pulses that serve to create temporary longi ⁇ tudinal/transverse waves in the breast tissue.
  • Registration of images taken at different times (of the same breast) is accomplished by landmarks on the breast or areola - freckles, nevi, veins, etc - as a photographic image is captured .
  • NAASW non-acoustic anti-submarine warfare
  • waves can be produced by transducers or air jets. Unlike sonar or sonograms, the "echo" is not analyzed, but rather the shadow or propagating wave downstream of a mass .
  • the images can reveal changes to the un- derlying structure of the breast.
  • Existing enhancement algo ⁇ rithms including specular enhancement, diffuse gain, and mul ⁇ tiple simultaneous light-points can be used along with novel algorithms. Typically grazing (or raking) lighting angles will reveal otherwise unapparent bumps below the surface.
  • FIGURES 1 and 2 show :
  • FIGURE 1 based on a schematic view and a block diagram a setup of an appliance for detecting cancerous or noncancerous lumps in tissues of living beings, in particular a lump in a mamma .
  • FIGURE 2 a detailed view on a Hardware Component connected to a microcontroller of the appliance according to the FIGURE 1.
  • FIGURE 1 shows based on a schematic view and a block diagram a setup of an Appliance APP for detecting cancerous or non ⁇ cancerous Lumps LUM in Tissues TIS of living beings, in par ⁇ ticular a Lump LUM in a Mamma MAM.
  • Detecting cancerous or noncancerous Lumps LUM in Tissues TIS of living beings, in particular the Lump LUM in the Mamma MAM or breasts encompasses any kind or variety of a classical sign of inflamma ⁇ tion of the Tissue TIS such as tumors or adipose tumors and is not limited to the following preferred embodiment of the invention detecting cancerous or noncancerous the Lump LUM in the Mamma MAM.
  • the Appliance APP shown in FIGURE 1 includes a Hardware Com ⁇ ponent HWCO which is designed or constructed in a first form of the preferred embodiment as a Stationary Device SDE and in a second form of the preferred embodiment as a Handheld De- vice HDE .
  • the Appliance APP includes a Microcon ⁇ troller MIC with a Processor PRC and a processor-assigned Storage Media STM as well as a "Polynomial Texture Mapping (PTM) "-Program Module PTMPM, a Modeling Program Module MPM and a Hardware Control Program Module HWCPM running on the Processor PRC and stored in the processor-assigned Storage Media STM.
  • PTM Polynomial Texture Mapping
  • the Appliance APP comprising the Hardware Compo ⁇ nent HWCO and the Microcontroller MIC is preferably designed as an appliance where either the Microcontroller MIC func ⁇ tions as an embedded system (where the microcontroller is somehow embedded in the Hardware Component) or where accord ⁇ ing to the representation in the FIGURE 1 it is an assembly with separated parts, a first part including the Hardware Component HWCO and a second part including the Microcontrol ⁇ ler MIC with the "Polynomial Texture Mapping ( PTM) "-Program Module PTMPM, die Modeling Program Module MPM and a Hardware Control Program Module HWCPM.
  • PTM Polynomial Texture Mapping
  • the Microcontroller MIC with the "Polynomial Texture Mapping (PTM) "-Program Module PTMPM, the Modeling Program Module MPM and the Hardware Control Program Module HWCPM is preferably a Personal Computer (PC) such as a Desktop-PC, a Notebook, a Tablet-PC.
  • PC Personal Computer
  • the Hardware Component HWCO and the Microcontroller MIC are connected such that both the Hardware Component in the form of the Stationary Device SDE and the Hardware Compo ⁇ nent in the form of the Handheld Device HDE or only one of them forms a Functional Unit FTU.
  • the Hardware Component HWCO formed as Stationary Device SDE includes a Dome DOM contain ⁇ ing at least one opto-mechanical Scan-Element SCE and at least one opto-mechanical Image-Capture-Element ICE, which for the detecting purpose are in particular alternately and radially arranged inside the Dome DOM.
  • the opto-mechanical Scan-Element SCE is each a light source such as "Light Emitting Diode (LED)", a fiber-optic, a mirror or a flash-bulb and at least one of switchable, modifiable in the element position and fixed.
  • LED Light Emitting Diode
  • the opto-mechanical Image-Capture-Element ICE is each a cam- era and at least one of modifiable in the element position and fixed.
  • the Dome DOM is designed such that at least one of accommo ⁇ dating subject variation, allowing tests under pressure or vacuum such as a controlled air or fluid pressures and allow ⁇ ing automated introduction of low-energy waves such as sound or air-jet pulses serve to create temporary longitudi ⁇ nal/transverse waves in the Tissue TIS.
  • the difference between the Hardware Component HWCO formed as Stationary Device SDE and the Hardware Component HWCO formed as Handheld Device HDE is that the Dome DOM of the Stationary Device SDE is driven by a motor (cf. the description of
  • FIGURE 2 3D-movable, which means that the Dome DOM can be positioned controlled by the Microcontroller MIC with the
  • the Dome DOM is in particular at least one of rotatable, tiltable and pivotable, whereas the Dome DOM of the Handheld Device HDE is held in the hand of a doctor who moves the device towards the Mamma MAM for detecting cancerous or noncancerous Lumps LUM in the Tissue TIS manually and not supported by the Microcontroller with the Processor PRC and the Hardware Control Program Mod- ule HWCPM.
  • the Hardware Component HWCO comprises further in both forms, the Stationary Device SDE and the Handheld Device HDE, a Da ⁇ ta-Interface DIF being connected to the at least one of the opto-mechanical Image-Capture-Elements ICE via which the data of images of the Mamma MAM captured by the opto-mechanical Image-Capture-Element ICE are forwarded to the Processor PRC of the Microcontroller MIC and a Control-Interface CIF being connected to the at least one of the opto-mechanical Scan- Elements SCE via which in both forms lightning pattern of the Scan-Element SCE are controlled by the Microcontroller MIC with the Processor PRC and the Hardware Control Program Mod ⁇ ule HWCPM.
  • Control-Interface CIF is further used such that via the Control-Interface CIF the 3D-movable, in particular at least one of rotatable, tiltable and pivotable, Dome DOM of the Stationary Device SDE is controlled by the Microcontroller MIC with the Processor PRC and the Hardware Control Program Module HWCPM.
  • the so formed Functional Unit FTU of the Microcontroller MIC with the Processor PRC and the processor-assigned Storage Me ⁇ dia STM as well as the "Polynomial Texture Mapping (PTM)"- Program Module PTMPM, the Modeling Program Module MPM and the Hardware Control Program Module HWCPM and the Hardware Compo ⁇ nent HWCO is designed such that
  • the Microcontroller MIC is connected with a Display DPL and/or a Printer PRT .
  • the created model can be outputted temporarily.
  • the outputted models are thereby at least one of recorded and correspondingly used for longitudinally studying purposes .
  • the Hardware Component HWCO in the form of the Stationary Device SDE includes further a Trans ⁇ ducer TRD supporting the detection of Lumps LUM in the Tissue TIS of living beings, in particular Lumps LUM in the Mamma MAM.
  • the Hardware Component HWCO in the form of the Handheld Device HDE includes such a transducer.
  • FIGURE 2 shows a detailed view on the Hardware Component HWCO formed as the Stationary Device SDE and connected to the Mi ⁇ crocontroller MIC of the Appliance APP according to the
  • FIGURE 1 In the FIGURE 2 it is exemplarily shown how
  • the Scan-Elements SCE and the Image-Capture-Elements ICE are arranged inside the Dome DOM in order to detect cancerous or noncancerous Lumps LUM in Tissues (TIS) of living beings, in particular the Lump LUM in the Mamma MAM, when the Mamma MAM is positioned underneath of the Dome DOM,

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Quality & Reliability (AREA)
  • Dermatology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

Le problème que cherche à résoudre la présente invention est de concevoir un appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire, qui augmente la couverture et la tolérance d'examens précis du sein. La présente invention propose de combiner des techniques et des technologies d'analyse de « mappage de textures polynomiales » (PTM) et de capture automatisée d'images de surface avec l'approche de déplacement de surface, l'analyse de motifs, et la propagation d'ondes via des supports physiques différenciés.
PCT/EP2014/076541 2014-12-04 2014-12-04 Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire WO2016086995A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/076541 WO2016086995A1 (fr) 2014-12-04 2014-12-04 Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/076541 WO2016086995A1 (fr) 2014-12-04 2014-12-04 Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire

Publications (1)

Publication Number Publication Date
WO2016086995A1 true WO2016086995A1 (fr) 2016-06-09

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PCT/EP2014/076541 WO2016086995A1 (fr) 2014-12-04 2014-12-04 Appareil de détection de masses cancéreuses ou non cancéreuses dans des tissus d'êtres vivants, en particulier d'une masse mammaire

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090195545A1 (en) * 2008-01-31 2009-08-06 University Fo Southern California Facial Performance Synthesis Using Deformation Driven Polynomial Displacement Maps
WO2012078280A1 (fr) * 2010-11-05 2012-06-14 Sonocine, Inc. Système d'imagerie d'élastographie
US8532736B1 (en) * 2005-07-29 2013-09-10 Hewlett-Packard Development Company, L.P. Apparatus and a method for quantifying properties of skin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8532736B1 (en) * 2005-07-29 2013-09-10 Hewlett-Packard Development Company, L.P. Apparatus and a method for quantifying properties of skin
US20090195545A1 (en) * 2008-01-31 2009-08-06 University Fo Southern California Facial Performance Synthesis Using Deformation Driven Polynomial Displacement Maps
WO2012078280A1 (fr) * 2010-11-05 2012-06-14 Sonocine, Inc. Système d'imagerie d'élastographie

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