WO2016082520A1 - Distributeur de fluide de colonne de chromatographie de type couplage de pression - Google Patents

Distributeur de fluide de colonne de chromatographie de type couplage de pression Download PDF

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Publication number
WO2016082520A1
WO2016082520A1 PCT/CN2015/080967 CN2015080967W WO2016082520A1 WO 2016082520 A1 WO2016082520 A1 WO 2016082520A1 CN 2015080967 W CN2015080967 W CN 2015080967W WO 2016082520 A1 WO2016082520 A1 WO 2016082520A1
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WO
WIPO (PCT)
Prior art keywords
fluid
distribution plate
gel
inlet
outlet
Prior art date
Application number
PCT/CN2015/080967
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English (en)
Chinese (zh)
Inventor
肖宇圻
Original Assignee
源创精科生物科技(长沙)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 源创精科生物科技(长沙)有限公司 filed Critical 源创精科生物科技(长沙)有限公司
Publication of WO2016082520A1 publication Critical patent/WO2016082520A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column

Definitions

  • the side surface is provided with a plurality of radially-shaped second fluid grooves distributed along the circumference, and a second screen is disposed outside the second fluid groove, and is formed between the edge of the second distribution plate and the end of the second fluid groove
  • An annular flow channel having a fluid inlet/outlet at a center of the second distribution plate, and a plurality of communicating annular flow channels and fluid inlet/outlet uniformly distributed on a surface of the second distribution plate opposite to the gel a radial flow path such that fluid exits/inletes from the first distribution plate through the first fluid channel, the first screen, the gel, the second screen, the second fluid channel, the annular flow channel, the radial flow path to
  • the length of any possible path of the fluid inlet/outlet of the second distribution plate is approximately the same, thereby causing the flow
  • the pressure loss in the flow path is substantially the same as any possible, resulting in substantially the same flow rate of fluid flowing per unit area of the gel.
  • a plurality of evenly distributed radial grooves are disposed on a surface of the second distribution plate opposite to the gel, and a plurality of radial grooves are respectively embedded in a thin tube, and the thin tube is connected One end of the annular flow channel is open, and the other end is closed. At the near closed end of the thin tube, an inlet/outlet hole and a flow path extending from the inlet/outlet port to the fluid inlet/outlet are provided.
  • Figure 9 is a schematic illustration of the flow path of a chromatography column of the present invention.

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

La présente invention concerne un distributeur de fluide de colonne de chromatographie de type couplage de pression. Le distributeur de fluide comprend une première plaque de distribution (20) et une seconde plaque de distribution (30) La première plaque de distribution (20) et la seconde plaque de distribution (30) sont respectivement disposées sur deux extrémités d'un gel à but de séparation (40) dans une colonne de chromatographie (10). De multiples premières rainures pour fluide radial (21) sont réparties de façon espacée le long de la circonférence d'une surface latérale, opposée au gel (40), de la première plaque de distribution (20). Une première maille d'écran (51) est disposée sur le côté extérieur de la première rainure pour fluide correspondante (21). Un orifice de sortie/d'entrée de fluide (22) en communication avec la première rainure pour fluide correspondante (21) est disposé au centre de la première plaque de distribution (20). De multiples secondes rainures pour fluide radial (31) sont réparties de façon espacée le long de la circonférence d'une surface latérale, opposée au gel (40), de la seconde plaque de distribution (30). Une seconde maille d'écran (52) est disposée sur le côté extérieur de la seconde rainure pour fluide correspondante (31). Une rainure d'écoulement annulaire (32) est formée entre le bord de la seconde plaque de distribution (30) et l'extrémité de queue de la seconde rainure pour fluide correspondante (31). Un orifice d'entrée/de sortie de fluide (33) est disposé au centre de la seconde plaque de distribution. Plusieurs canaux d'écoulement radia (34) pour connecter les rainures d'écoulement annulaire (32) et l'orifice d'entrée/de sortie de fluide (33) sont répartis de manière régulière dans la surface latérale, opposée au gel, de la seconde plaque de distribution.
PCT/CN2015/080967 2014-11-26 2015-06-08 Distributeur de fluide de colonne de chromatographie de type couplage de pression WO2016082520A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410697242.0A CN104436757B (zh) 2014-11-26 2014-11-26 压力耦合式层析柱流体分配器
CN201410697242.0 2014-11-26

Publications (1)

Publication Number Publication Date
WO2016082520A1 true WO2016082520A1 (fr) 2016-06-02

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PCT/CN2015/080967 WO2016082520A1 (fr) 2014-11-26 2015-06-08 Distributeur de fluide de colonne de chromatographie de type couplage de pression

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CN (1) CN104436757B (fr)
WO (1) WO2016082520A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11185830B2 (en) 2017-09-06 2021-11-30 Waters Technologies Corporation Fluid mixer
US11555805B2 (en) 2019-08-12 2023-01-17 Waters Technologies Corporation Mixer for chromatography system
US11821882B2 (en) 2020-09-22 2023-11-21 Waters Technologies Corporation Continuous flow mixer
US11898999B2 (en) 2020-07-07 2024-02-13 Waters Technologies Corporation Mixer for liquid chromatography
US11988647B2 (en) 2020-07-07 2024-05-21 Waters Technologies Corporation Combination mixer arrangement for noise reduction in liquid chromatography

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104436757B (zh) * 2014-11-26 2017-10-27 源创精科生物科技(长沙)有限公司 压力耦合式层析柱流体分配器

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CN103221817A (zh) * 2010-11-29 2013-07-24 通用电气健康护理生物科学股份公司 用于将层析柱的分配器板固定到背板上的方法和层析柱
CN203678007U (zh) * 2013-11-29 2014-07-02 栗云天 具有二级流道的层析柱的液体分配器
CN104436757A (zh) * 2014-11-26 2015-03-25 长沙市源创精科生物技术有限公司 压力耦合式层析柱流体分配器
CN204337830U (zh) * 2014-11-26 2015-05-20 长沙市源创精科生物技术有限公司 压力耦合式层析柱流体分配器

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US5324426A (en) * 1992-03-20 1994-06-28 Kontes Glass Corp. Chromatography column
US6942794B2 (en) * 2003-03-21 2005-09-13 Millipore Corporation High velocity chromatography column flow distributor
GB0322144D0 (en) * 2003-09-23 2003-10-22 Amersham Biosciences Ab Chromatography column distribution system
WO2010002383A1 (fr) * 2008-06-30 2010-01-07 Uop Llc Appareil de distribution d'écoulement
GB2485838A (en) * 2010-11-29 2012-05-30 Ge Healthcare Bio Sciences Ab Chromatography column
CN202366510U (zh) * 2011-11-28 2012-08-08 顾雄毅 一种可用于生物制药中扩张床设备的液体分布器
CN103505909B (zh) * 2012-06-21 2018-02-13 通用电气健康护理生物科学股份公司 层析柱框架和对层析柱进行维护和填充的方法
CN103638692B (zh) * 2013-11-29 2016-03-02 源创精科生物科技(长沙)有限公司 具有二级流道的层析柱的液体分配器

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221817A (zh) * 2010-11-29 2013-07-24 通用电气健康护理生物科学股份公司 用于将层析柱的分配器板固定到背板上的方法和层析柱
CN203678007U (zh) * 2013-11-29 2014-07-02 栗云天 具有二级流道的层析柱的液体分配器
CN104436757A (zh) * 2014-11-26 2015-03-25 长沙市源创精科生物技术有限公司 压力耦合式层析柱流体分配器
CN204337830U (zh) * 2014-11-26 2015-05-20 长沙市源创精科生物技术有限公司 压力耦合式层析柱流体分配器

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11185830B2 (en) 2017-09-06 2021-11-30 Waters Technologies Corporation Fluid mixer
US11555805B2 (en) 2019-08-12 2023-01-17 Waters Technologies Corporation Mixer for chromatography system
US11898999B2 (en) 2020-07-07 2024-02-13 Waters Technologies Corporation Mixer for liquid chromatography
US11988647B2 (en) 2020-07-07 2024-05-21 Waters Technologies Corporation Combination mixer arrangement for noise reduction in liquid chromatography
US11821882B2 (en) 2020-09-22 2023-11-21 Waters Technologies Corporation Continuous flow mixer

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CN104436757A (zh) 2015-03-25
CN104436757B (zh) 2017-10-27

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