WO2016080852A1 - Led illuminator with a fiber optic output - Google Patents

Led illuminator with a fiber optic output Download PDF

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Publication number
WO2016080852A1
WO2016080852A1 PCT/PL2015/000187 PL2015000187W WO2016080852A1 WO 2016080852 A1 WO2016080852 A1 WO 2016080852A1 PL 2015000187 W PL2015000187 W PL 2015000187W WO 2016080852 A1 WO2016080852 A1 WO 2016080852A1
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
lens
led diode
focusing lens
situated
Prior art date
Application number
PCT/PL2015/000187
Other languages
French (fr)
Other versions
WO2016080852A4 (en
Inventor
Zakłady Farmaceutyczne Polfa Spółka Akcyjna Tarchomińskie
Mirosław KWAŚNY
Zygmunt Mierczyk
Mariusz ŁAPIŃSKI
Jerzy BARAŃSKI
Andrzej GIETKA
Original Assignee
Tarchomińskie Zakłady Farmaceutyczne P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tarchomińskie Zakłady Farmaceutyczne P filed Critical Tarchomińskie Zakłady Farmaceutyczne P
Publication of WO2016080852A1 publication Critical patent/WO2016080852A1/en
Publication of WO2016080852A4 publication Critical patent/WO2016080852A4/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0005—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
    • G02B6/0006—Coupling light into the fibre
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21Y—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES F21K, F21L, F21S and F21V, RELATING TO THE FORM OR THE KIND OF THE LIGHT SOURCES OR OF THE COLOUR OF THE LIGHT EMITTED
    • F21Y2105/00—Planar light sources
    • F21Y2105/10—Planar light sources comprising a two-dimensional array of point-like light-generating elements
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21Y—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES F21K, F21L, F21S and F21V, RELATING TO THE FORM OR THE KIND OF THE LIGHT SOURCES OR OF THE COLOUR OF THE LIGHT EMITTED
    • F21Y2115/00—Light-generating elements of semiconductor light sources
    • F21Y2115/10—Light-emitting diodes [LED]
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0004—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed
    • G02B19/0028—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed refractive and reflective surfaces, e.g. non-imaging catadioptric systems

Definitions

  • the subject of the invention is an illuminator, the structure of which is based on a light-emitting diode (LED) matrix, to be applied in diagnostic imaging and in therapy with application of the photodynamic method.
  • LED light-emitting diode
  • the invention is associated with the field of optoelectronics and devices applied, in particular, in the process of diagnostic imaging and treatment of some dermatological ailments with the application of the photodynamic method.
  • An exposing device based on a halogen bulb is known from claim P. 336944.
  • the light from a halogen bulb or another, similar source of incoherent light, is directed through an elliptic mirror towards one final surface.
  • An exposing device used in the photodynamic method, based on a source of light from LED diodes, is known from claim W02014166993.
  • a device based on two lamps, used for exposures with the use of the photodynamic method, is known from claim US2014067024.
  • the objective of the invention is to develop a device that will allow point exposure (of small areas of the body, e.g. 1 cm2), to provide uniform distiibution of the beam of light emitted by the LED diodes, and to conduct the exposures in the areas of the body that are difficult to get access to.
  • the illuminator is based on a LED diode matrix. What is important in the application of the photo dynamic method, it allows to emit the radiation of the wavelength of 400-410 nm, 630-640 nm and 660-675nm, with the possibility of a single wavelength, in a continuous or periodical mode.
  • the radiation of the wavelength of about 405 is used for diagnostic imaging, of the wavelength of about 635 - for photodynamic therapy (PDT) with the use of 5 -aminolevulinic acid.
  • PPT photodynamic therapy
  • the photosensitizer - protoporphyrin IX (PPIX) is decomposed to the product with the absorption band of the wavelength of about 66 Onm.
  • the diode with such a range allows to use the products of decomposition of the suitable sensitizer in therapy in a more efficient manner.
  • the radiation emitted from the LED matrix is concentrated with a specifically designed optic system for the fiber optic cable.
  • a very important advantage of the radiation emitted after leaving the fiber optic cable is the uniform surface distribution of the beam, which cannot be performed when lighting directly from a fiat matrix with diodes or other sources of light. In such a case, there are observable distinct interruptions or fields of smaller intensity, resulting from the physical impossibility to distribute the diodes very densely.
  • the thin, flexible fiber optic cable also highly facilitates the access to any place in the body, without the need to change the position of the source or of the patient.
  • the illuminator may be used in diagnostic imaging (PDD) and in treating certain dermatological ailments (e.g. basal cell cancer, senile or light keratosis, papillae, disease) through the photodynamic method (PDT), with the use of the 5 -aminolevulinic acid as the precursor of the suitable photosensitizer.
  • PDT photodynamic method
  • the use of a narrow spectral band of emitting diodes allows to optimally adapt the wavelength to the PPIX absorption bands.
  • the level of power behind the fiber optic cable of about 500 mW, allows to radiate the area of the body of between 1 and 10 cm2, so the source is universal both for the lesions of very small and very large surface area. It is very important, for example when radiating the skin near the eyes.
  • the diode matrix also includes the diodes of the wavelength of 400-410 that generate strong, red PPIX fluorescence, visible even in daylight. This allows to precisely select the area of the radiated tissue and to estimate the time after which the accumulation of pigment in the tissue is highest.
  • a uniform light beam leaves the flexible fiber optic cable, which facilitates reaching the parts of the body that are difficult to access, and conducting point radiations.
  • the illuminator contains a light source in the form of a LED diode matrix and an optic system in which the LED diode matrix has a central hole with a lens.
  • a focusing lens matrix behind which the optical radiation beam is parallel.
  • the matrices have a central hole smaller than the lens diameter.
  • a concave mirror at a distance that allows to focus all the parallel light beams leaving the focusing lens matrix, by reflecting from the concave mirror on the lens, and introducing them to the fiber optic cable.
  • the fiber optic cable attached mechanically, and the LED diode matrix and the focusing lens matrix and the concave mirror, are permanently attached mechanically in the housing.
  • the LED diode matrix prefferably contains the diodes that allow to emit the radiation of the wavelength of 400-410 nm.
  • the LED diode matrix prefferably contains the diodes that allow to emit the radiation of the wavelength of 630-640 nm.
  • the LED diode matrix prefferably contains the diodes that allow to emit the radiation of the wavelength of 660-675 nm. It is preferable for the focusing lens matrix to possess the number of lens equal to the number of LED diodes in the Led diode matrix.
  • the lens from the focusing lens matrix prefferably be situated in the longitudinal axis of each LED diode in the LED diode matrix.
  • the fiber optic cable prefferably be a liquid fiber optic cable.
  • the illuminator is constructed in an open metal housing 8 of perpendicular structure, whose structure rigidity is provided by the mechanical structure brackets.
  • Housing 8 contains a LED diode matrix 3 of the diameter of 110 mm and thickness of 5 mm, consisting of 161 diodes inserted in the mechanical element. Those diodes allow to emit the radiation of the wavelength of 635 nm.
  • the LED diode matrix 3 contains a central hole with the lens 4 of the diameter of 20 mm. Directly in front of the LED diode matrix 3 there is situated a focusing lens matrix 2, consisting of 161 lens that make the optical radiation beam parallel, and that are situated coaxially to the LED diodes.
  • the focusing lens matrix 2 has the same dimensions as the LED diode matrix 3, and it also has a central hole of the diameter equal to the lens 4 diameter.
  • a concave mirror 1 of the focal length of f 130 mm. The mentioned distance allows to focus all the parallel light beams leaving the focusing lens of the matrix 2, by reflecting from the concave mirror 1 on the lens 4, and the light beam to the fiber optic cable 5 situated directly behind the lens 4.
  • a liquid fiber optic cable of the diameter of 8 mm was used. It was mechanically attached with a clamp nut 7, so that its end touches the lens 4.
  • the invention will find an industrial application in photodiagnosis and therapy with application of the photo dynamic method.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Radiation-Therapy Devices (AREA)
  • Led Device Packages (AREA)

Abstract

The invention is associated with an illuminator containing light sources in the form of a LED diode matrix and an optical system. The LED diode matrix (3) has a central hole with the lens (4) situated there, and in front of the LED diode matrix (3) there is situated the focusing lens matrix (2) which makes the optic radiation beams parallel. The focusing lens matrix (2) has a central hole, no smaller than the diameter of the lens (4). In front of the focusing lens matrix (2), there is situated a concave mirror (1) at a distance that allows to focus all the parallel light beams leaving the focusing lens matrix (2), by reflecting from the concave mirror (1) on the lens (4). Directly behind the lens (4) there is situated the fiber optic cable (5). The LED diode matrix (3) and the focusing lens matrix (2) and the concave mirror (1), are permanently attached mechanically in the housing (8).

Description

LED ILLUMINATOR WITH A FIBER OPTIC OUTPUT
DESCRIPTION
TECHNICAL FIELD
The subject of the invention is an illuminator, the structure of which is based on a light-emitting diode (LED) matrix, to be applied in diagnostic imaging and in therapy with application of the photodynamic method.
The invention is associated with the field of optoelectronics and devices applied, in particular, in the process of diagnostic imaging and treatment of some dermatological ailments with the application of the photodynamic method.
BACKGROUND ART
There are available illuminators for use in diagnostics and therapy with the application of the photodynamic method, in which the light sources are LED diodes.
An exposing device based on a halogen bulb is known from claim P. 336944. The light from a halogen bulb or another, similar source of incoherent light, is directed through an elliptic mirror towards one final surface.
An exposing device used in the photodynamic method, based on a source of light from LED diodes, is known from claim W02014166993.
A device based on two lamps, used for exposures with the use of the photodynamic method, is known from claim US2014067024.
Current solutions do not allow point exposures. There also exist problems with applying exposures in the parts of the body that are difficult to reach. Lack of the possibility to provide uniform distribution of the light beam is also a problem.
The objective of the invention is to develop a device that will allow point exposure (of small areas of the body, e.g. 1 cm2), to provide uniform distiibution of the beam of light emitted by the LED diodes, and to conduct the exposures in the areas of the body that are difficult to get access to. DISCLOSURE OF THE INVENTION
The illuminator is based on a LED diode matrix. What is important in the application of the photo dynamic method, it allows to emit the radiation of the wavelength of 400-410 nm, 630-640 nm and 660-675nm, with the possibility of a single wavelength, in a continuous or periodical mode. The radiation of the wavelength of about 405 is used for diagnostic imaging, of the wavelength of about 635 - for photodynamic therapy (PDT) with the use of 5 -aminolevulinic acid. During therapeutic radiation, the photosensitizer - protoporphyrin IX (PPIX) is decomposed to the product with the absorption band of the wavelength of about 66 Onm. The diode with such a range allows to use the products of decomposition of the suitable sensitizer in therapy in a more efficient manner. The radiation emitted from the LED matrix is concentrated with a specifically designed optic system for the fiber optic cable.
A very important advantage of the radiation emitted after leaving the fiber optic cable, is the uniform surface distribution of the beam, which cannot be performed when lighting directly from a fiat matrix with diodes or other sources of light. In such a case, there are observable distinct interruptions or fields of smaller intensity, resulting from the physical impossibility to distribute the diodes very densely.
The thin, flexible fiber optic cable also highly facilitates the access to any place in the body, without the need to change the position of the source or of the patient.
The illuminator may be used in diagnostic imaging (PDD) and in treating certain dermatological ailments (e.g. basal cell cancer, senile or light keratosis, papillae, disease) through the photodynamic method (PDT), with the use of the 5 -aminolevulinic acid as the precursor of the suitable photosensitizer. The use of a narrow spectral band of emitting diodes allows to optimally adapt the wavelength to the PPIX absorption bands. The level of power behind the fiber optic cable of about 500 mW, allows to radiate the area of the body of between 1 and 10 cm2, so the source is universal both for the lesions of very small and very large surface area. It is very important, for example when radiating the skin near the eyes.
An important advantage of the PDT method is that it uses the fluorescent properties of the substance synthetized in the sick tissues, for diagnostic puiposes (Photodynamic diagnosis - PDD). Apart from the fundamental LEDs emitting the therapeutic radiation of the suitable wavelength, the diode matrix also includes the diodes of the wavelength of 400-410 that generate strong, red PPIX fluorescence, visible even in daylight. This allows to precisely select the area of the radiated tissue and to estimate the time after which the accumulation of pigment in the tissue is highest.
A uniform light beam leaves the flexible fiber optic cable, which facilitates reaching the parts of the body that are difficult to access, and conducting point radiations.
The illuminator contains a light source in the form of a LED diode matrix and an optic system in which the LED diode matrix has a central hole with a lens. In front of the LED diode matrix there is situated a focusing lens matrix, behind which the optical radiation beam is parallel. The matrices have a central hole smaller than the lens diameter. In front of the focusing lens matrix, there is situated a concave mirror at a distance that allows to focus all the parallel light beams leaving the focusing lens matrix, by reflecting from the concave mirror on the lens, and introducing them to the fiber optic cable. Directly behind the lens, there is situated the fiber optic cable attached mechanically, and the LED diode matrix and the focusing lens matrix and the concave mirror, are permanently attached mechanically in the housing.
It is preferable for the LED diode matrix to contain the diodes that allow to emit the radiation of the wavelength of 400-410 nm.
It is preferable for the LED diode matrix to contain the diodes that allow to emit the radiation of the wavelength of 630-640 nm.
It is preferable for the LED diode matrix to contain the diodes that allow to emit the radiation of the wavelength of 660-675 nm. It is preferable for the focusing lens matrix to possess the number of lens equal to the number of LED diodes in the Led diode matrix.
It is preferable for the lens from the focusing lens matrix to be situated in the longitudinal axis of each LED diode in the LED diode matrix.
It is preferable for the fiber optic cable to be a liquid fiber optic cable.
The beneficial example of development of the subject invention has been presented in the drawing in Fig. 1, presenting the arrangement of the illuminator elements within the housing, while Fig. 1 presents the illuminator's optical diagram as per the invention. THE BEST MODE OF CARRYING OUT THE INVENTION
Based on the invention, the illuminator is constructed in an open metal housing 8 of perpendicular structure, whose structure rigidity is provided by the mechanical structure brackets. Housing 8 contains a LED diode matrix 3 of the diameter of 110 mm and thickness of 5 mm, consisting of 161 diodes inserted in the mechanical element. Those diodes allow to emit the radiation of the wavelength of 635 nm. The LED diode matrix 3 contains a central hole with the lens 4 of the diameter of 20 mm. Directly in front of the LED diode matrix 3 there is situated a focusing lens matrix 2, consisting of 161 lens that make the optical radiation beam parallel, and that are situated coaxially to the LED diodes. The focusing lens matrix 2 has the same dimensions as the LED diode matrix 3, and it also has a central hole of the diameter equal to the lens 4 diameter. In front of the focusing lens matrix 2, at a distance of 150 mm, there is situated a concave mirror 1 of the focal length of f = 130 mm. The mentioned distance allows to focus all the parallel light beams leaving the focusing lens of the matrix 2, by reflecting from the concave mirror 1 on the lens 4, and the light beam to the fiber optic cable 5 situated directly behind the lens 4. hi the example, a liquid fiber optic cable of the diameter of 8 mm was used. It was mechanically attached with a clamp nut 7, so that its end touches the lens 4.
INDUSTRIAL APPLICABILITY
The invention will find an industrial application in photodiagnosis and therapy with application of the photo dynamic method.

Claims

THE CLAIMS
Illuminator with the light source in the form of a LED diode matrix and an optic system, characterized in that the LED diode matrix (3) has a central hole with a lens (4), and in front of the LED diode matrix (3) there is situated a focusing lens matrix (2), behind which the optical radiation beam is parallel, possessing a central hole not smaller than the lens (4) diameter, and in front of the focusing lens matrix
(2) there is situated a concave mirror (1) at the distance that allows to concentrate all the parallel light beams leaving the focusing lens matrix (2) by reflecting from the concave mirror (1) on the lens (4) and directly behind the lens (4) there is situated a fiber optic cable (5) attached mechanically, while the LED diode matrix
(3) , focusing lens matrix (2) and concave mirror (1) are attached permanently and mechanically in the housing (8).
Based on claim 1 , the illuminator is characterized in that the LED diode matrix (3) contains the diodes that allow to emit the radiation of the wavelength of: 400 nm - 410 nm.
Based on claim 1,2, the illuminator is characterized in that the LED diode matrix (3) contains the diodes that allow to emit the radiation of the wavelength of: 630 nm - 640nm.
Based on claim 1,2,3, the illuminator is characterized in that the LED diode matrix (3) contains the diodes that allow to emit the radiation of the wavelength of: 660 nm - 675 nm.
Based on claim 1,2,3,4, the illuminator is characterized in that the number of lens in the focusing lens matrix (2) is equal to the number of the LED diodes in the LED diode matrix (3).
Based on claim 1,2,3,4,5, the illuminator is characterized in that a lens from the focusing lens matrix (2) is situated in the longitudinal axis of each LED diode in the LED diode matrix (3).
Based on claim 1,2,3,4,5,6, the illuminator is characterized in that the fiber optic cable (5) is a liquid fiber optic cable.
PCT/PL2015/000187 2014-11-17 2015-11-17 Led illuminator with a fiber optic output WO2016080852A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL410162A PL410162A1 (en) 2014-11-17 2014-11-17 LED illuminator with fibre optic output
PLP.410162 2014-11-17

Publications (2)

Publication Number Publication Date
WO2016080852A1 true WO2016080852A1 (en) 2016-05-26
WO2016080852A4 WO2016080852A4 (en) 2016-07-28

Family

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Family Applications (1)

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PCT/PL2015/000187 WO2016080852A1 (en) 2014-11-17 2015-11-17 Led illuminator with a fiber optic output

Country Status (2)

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WO (1) WO2016080852A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2979522B2 (en) * 1994-02-28 1999-11-15 株式会社島津製作所 Light source device for curing photo-curable resin
US20030147255A1 (en) * 2002-02-01 2003-08-07 Samsung Electronics Co., Ltd. Illumination system and projection display device employing the same
US20090040754A1 (en) * 2007-08-06 2009-02-12 Lumencor, Inc. Light emitting diode illumination system
US20100208487A1 (en) * 2009-02-13 2010-08-19 PerkinElmer LED Solutions, Inc. Led illumination device
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
WO2014166993A1 (en) 2013-04-09 2014-10-16 Photocure Asa Irradiation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2979522B2 (en) * 1994-02-28 1999-11-15 株式会社島津製作所 Light source device for curing photo-curable resin
US20030147255A1 (en) * 2002-02-01 2003-08-07 Samsung Electronics Co., Ltd. Illumination system and projection display device employing the same
US20090040754A1 (en) * 2007-08-06 2009-02-12 Lumencor, Inc. Light emitting diode illumination system
US20100208487A1 (en) * 2009-02-13 2010-08-19 PerkinElmer LED Solutions, Inc. Led illumination device
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
WO2014166993A1 (en) 2013-04-09 2014-10-16 Photocure Asa Irradiation device

Also Published As

Publication number Publication date
PL410162A1 (en) 2016-05-23
WO2016080852A4 (en) 2016-07-28

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