RU120879U1 - DEVICE FOR LOCAL PUVA THERAPY - Google Patents

Abstract

A device for local PUVA therapy, containing a timer and a frame, on the inside of which UV LEDs with electrical contacts are installed for connection to a power source, characterized in that the timer is installed in the power circuit between the power source and UV LEDs with a wavelength of at least 335 nm, and the frame is equipped with a tripod and hinge assembly.

Description

The utility model relates to medical instruments for dermatological applications and can be used for treatment with PUVA therapy for psoriasis, local atopic dermatitis, vitiligo, superficial mycoses, as well as for biostimulation of the body in order to eliminate pain, inflammatory, edematous syndromes, improve local and general blood flow.

Known devices for biostimulation based on the use of radiation in the optical range - ultraviolet, visible, infrared. "Handbook of Physiotherapy", ed. V.G. Krasnogorodsky. M. Medicine, 1992, p. 15-18.

Known devices that generate monochromatic coherent (laser) and incoherent (LEDs) radiation in the optical range, which is a more effective biostimulator. V.I. Kozlov, V.A. Builin, "Laser therapy", Moscow-Vladivostok, 1992.

Known LED device for photodynamic therapy, containing a matrix of at least 100 LEDs, coupled with conical optical fibers, focons arranged in a bundle. Utility Model Patent of the Russian Federation No. 2512, IPC: A61N 5/06, 1996

A device is known for phototherapy of neoplasms, including as a light source a matrix of LEDs on a flat substrate. U.S. Patent 5698866, A61N 5/06, 1997

A device for phototherapy containing a cylindrical body, a power source with an adjustment unit, an infrared LED with a power of up to 200 mW, the control unit has a timer for 3 and 5 minutes and a power regulator to prevent skin burns. Patent of the Russian Federation No. 2141363, IPC: A61N 5/06, 1999

A device for phototherapy and fluorescence diagnostics of pathological areas, including a housing, a matrix of LEDs located on the housing, a camera with a spectrally selective optical system located in the center of the housing, and a video information display system are known. The housing is made in the form of a segment of a spherical surface, the LEDs are located on the housing so that the optical axis of the radiation of the LEDs intersect at one point. The spectral emission range of LEDs lies in the wavelength range of the maximum absorption of the photosensitizer. Patent of the Russian Federation No. 2176475, IPC: АВВ 5/05, 2001

A device for ultraviolet irradiation is known, containing a radiation source in the form of an LED operating in the ultraviolet range, the LED being mounted on the wall and / or ceiling of the room. Patent of the Russian Federation for utility model No. 91677 IPC: A61D 99/00, 2010. The irradiator consists of a housing with built-in LEDs and a power source. The power supply provides operation of UV LEDs, for example UVTOP 280-FW, with a stabilized current of 20 mA, resulting in the generation of directional UV radiation in the range of 280 nm ± 5 nm. The indicated wavelength range is not suitable for PUVA therapy.

Known sections for the installation of ultraviolet lamps in the irradiation zone. The section contains a frame with a number of lamps installed in it. The lamps are arranged with an arbitrary or constant pitch between their longitudinal axes. Each lamp has electrical contacts and is enclosed in a protective tube. The pipe is made of ultraviolet transmitting material. Patent of the Russian Federation No. 2057718, IPC: С02F 1/32, 1996. The arrangement of lamps with an arbitrary step L does not provide optimal absorption of the ultraviolet energy flux, which negatively affects the irradiation efficiency. A device is known for local PUVA therapy, comprising a timer and a frame, on the inside of which UV-LEDs with electrical contacts are mounted for connection to a power source. Patent of the Russian Federation No. 2385451, IPC: G01J 1/42, 2010. Prototype. The device is a rigid structure, and the emitters have a UV spectrum with 320 nm.

A wide spectrum of radiation partially coincides with the absorption spectrum of DNA, which leads to the risk of mutations and the occurrence of cancer. UV radiation affects thymine and guanine (the region of overlapping spectra is marked by a darkened field). The effect of UV radiation on tryptophan leads to its destruction and degradation of the collagen protein, which ultimately leads to photoaging of the skin. Exposure to guanine in DIC can lead to mutations and the appearance of malignant neoplasms. There is a problem of uneven exposure to the patient. This leads to the fact that certain parts of the patient’s body receive an excessive dose of ultraviolet radiation, while others receive it less.

The technical and medical result of the utility model is uniform irradiation of the patient’s skin, elimination of the risk of mutations in DNA molecules and destruction of polypeptide chains in the collagen of skin cells during PUVA therapy, excitation of psoralen molecules without DNA damage.

The technical and medical result is achieved by the fact that in the device for local PUVA therapy, which contains a timer and a frame, on the inside, which have UV LEDs with electrical contacts for connecting to a power source, a timer is installed in the power circuit between the power source and UV LEDs with a wavelength of at least 335 nm, and the frame is equipped with a tripod and a hinge assembly.

The essence of the utility model is illustrated in figures 1-8.

In FIG. 1 shows a device for local PUVA therapy, where: 1-frame, 2 - UV - LEDs, 3 - timer.

Figure 2 presents the molecules of photosensitizers.

Figure 3 presents the absorption spectrum of DNA.

Figure 4 shows the emission spectrum of a Philips Gleo Performance lamp

Figure 5 presents the absorption spectrum of guanine.

Figure 6 presents the absorption spectrum of thymine.

7. The graph of the intensity of the Philips Cleo Perfomance lamp versus the distance to its base is presented.

On Fig. A graph of the intensity of the Lighttech 80W lamp from the distance to its base is presented.

PUVA therapy (an acronym for the combination of psoralen and UV radiation of region A) is used to treat moderate and severe psoriasis, as well as to weaken those forms of psoriasis that cannot be treated with other drugs.

Psoralen (furocoumarin) is a photochemically active substance that, when it enters the cell, binds to hydrophobic structures (due to poor solubility in water).

Geometrically, the molecules of furocoumarins are flat molecules, and in structure resemble a pair of complementary DNA bases (Fig. 2). This allows the molecule to easily fit between two pairs of DNA bases. This process is reversible, and with a decrease in the concentration of psoralen in the body, they leave the DNA. For DNA crosslinking to occur, it is necessary to irradiate the system with ultraviolet light. At a wavelength of more than 320 nm, DNA is not affected, and the psoralen molecule goes into an excited state. "Molecular photobiology"; Smith, K .; Hanewalt, F .; Publishing House: M .: Mir, 1972. In this state, the molecule is capable of forming strong covalent crosslinking with DNA thymine.

The formation of such cross-links prevents the molecule from spreading during cell division, which allows you to establish control over the number of cells. It should be noted that in healthy cells the mechanism of DNA repair is better implemented, and in them, as a rule, sections with cross-linked DNA strands are “bitten out”.

To obtain a therapeutic effect in PUVA therapy, a degree of surface irradiation that does not cause burns is necessary.

The radiation dose received by the patient depends on the power of the radiation source, its distance to the skin surface and the duration of the light exposure.

Currently they produce ultraviolet LEDs in a single and matrix design: UVTOP-335TFW LEDs, emission wavelength 335-345 nm, supply voltage - up to 6.2 W, power - 165-275 μW, Planar, S-Pb, Russia .

UV LEDs with a peak wavelength of 395-400 nm are produced both in the form of conventional 5 mm LEDs and in housings from 1 W to 5 W.

385 nm UV LEDs are mainly available in 5 mm cases.

Emitter's UV LEDs are available in standard 8 mm diameter LED housing with a wavelength of about 400 nm.

The use of LEDs in the form of a matrix allows you to get a more uniform illumination of the object and avoid the appearance of sharp shadows.

Matrices of the EdiLine series are supplied in the form of Edison E-Var modules, which have heat-conducting metal housings and connectors for connecting to a power source or combining several modules in a circuit. The power of a single UV LED is 14.13 mJ / s. This value is used to calculate the dose of skin irradiation according to the formula:

Skin irradiation time and radiation dose:

Time s Dose in J / cm ² fifteen 0.2 thirty 0.42 60 0.84 120 1,69 240 3.39

The procedures are as follows.

Assign procedures for general photochemotherapy of the local surface of the skin of the trunk, or arms, or legs, or shoulder girdle, or neck. Irradiation is carried out 3-4 times a week with a dose of aminofurin 20 mg per 20 kg of weight plus 20 mg, 30-40 minutes after a meal, 3 hours before the procedure.

Adjust the position of the frame 1 with a matrix of UV - LEDs 2 opposite the locally irradiated surface of the patient’s skin, turning the hinge and / or moving the frame along the height of the tripod. After the dose of radiation established by the doctor, include a timer 3.

Claims (1)

A device for local PUVA therapy, containing a timer and a frame, on the inside of which are installed UV LEDs with electrical contacts for connecting to a power source, characterized in that the timer is installed in the power circuit between the power source and UV LEDs with a wavelength of at least 335 nm, and the frame is equipped with a tripod and a hinge assembly.