WO2016066830A1 - Nébuliseur alimenté en gaz - Google Patents

Nébuliseur alimenté en gaz Download PDF

Info

Publication number
WO2016066830A1
WO2016066830A1 PCT/EP2015/075327 EP2015075327W WO2016066830A1 WO 2016066830 A1 WO2016066830 A1 WO 2016066830A1 EP 2015075327 W EP2015075327 W EP 2015075327W WO 2016066830 A1 WO2016066830 A1 WO 2016066830A1
Authority
WO
WIPO (PCT)
Prior art keywords
funnel
atomiser
housing
gas
liquid
Prior art date
Application number
PCT/EP2015/075327
Other languages
English (en)
Inventor
Philip CANNER
Original Assignee
Linde Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Linde Aktiengesellschaft filed Critical Linde Aktiengesellschaft
Publication of WO2016066830A1 publication Critical patent/WO2016066830A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas

Definitions

  • the present invention relates to a gas filed atomiser.
  • the present invention relates to a gas fed atomiser capable of producing and dispensing, by way of a funnel, a liquid mist ideally containing small droplets of therapeutic liquids.
  • Atomised liquids produced by such a device may be used for many purposes.
  • One such use is for therapy, for example, by application to the skin or by inhalation.
  • One example is the atomisation of sodium chloride for inhalation to assist with the removal of mucus and debris from the lungs.
  • Another example is atomisation of hyaluronic acid for skin beauty purposes.
  • a device for atomising liquids to form a mist is
  • EP 2626052 consists of a gas cylinder attached at its top end via a manifold to a separate
  • a face mask is attached at an outlet port on the top of the cartridge by which a user inhales the vapour.
  • a gas fed atomiser comprising a housing for receiving a pressurised gas cylinder and a cartridge of liquid, the pressurised gas being configured to atomise the liquid and dispense this liquid as a mist via an outlet in top of the housing, and a funnel rigidly fixed to the top of the housing with a narrow end and a flared end, the narrow end being in direct communication with the outlet in the top of the housing such that the atomised liquid travels up along the funnel to the flared end where it leaves the funnel in a region where a user can place their face for inhaling or applying the dispensed atomised liquid.
  • the present invention replaces the face mask of EP 2626052 with a funnel up through which the atomised liquid is dispensed and through a flared end on top of the device.
  • the device adopts a different approach in that it is a a device which gently dispenses a mist in an upward direction to a region over which a user can lean in order to inhale or apply the atomised liquid.
  • this is not such an efficient delivery mechanism as the face mask, for an inhaled
  • composition it is far more pleasant for the user, and also offers the possibility of being able to apply the atomised liquid to a wider region, namely across the users face, rather than simply into their mouth.
  • an orifice at the narrow end is in a first plane and an orifice at the flared end is in a second plane, the planes being inclined with respect to one another by between 1° and 45°, preferably 20° to 40°.
  • the flared end in particular, may have an undulating profile. If so, the second plane should be considered as a medium plane which can be drawn through the undulating end.
  • the flared end of the funnel is substantially within the
  • the flared end is effectively above the housing again providing an atomiser which is comfortable for the user to bend over.
  • the atomiser is a free standing unit and the housing is arranged to provide a stable support for the inhaler on a flat surface improving the convenience of the operation of the atomiser.
  • the flared end is substantially circular. This provides an attractive appearance to the device.
  • it may have a shape which is more profiled to fit a user's face.
  • the funnel is preferably detachable from the rest of the device. By being detachable, the funnel can be more easily cleaned between uses of the device. It may also be
  • the funnel is made of glass or plastic to make it easy to clean between uses.
  • an annular skirt depends downwardly from the flared end of the funnel to the housing with which it is continuous. This gives the device a pleasing look which will again enhance its acceptability to the user.
  • Figure 1A shows a plan view of the device including part of the lid with the lid open
  • Figure IB shows a perspective view of the device without the lid.
  • Figure 2 shows a perspective view of a gas cylinder and a cartridge useable in the device.
  • the Figure also shows the remaining components from the device, including the principal manifold component, that are responsible for delivering the gas from this cylinder to the cartridge.
  • Figure 3A shows in greater detail a perspective view of the manifold from the device which is used to deliver the gas from this cylinder to the cartridge;
  • Figure 3B shows a corresponding view to Figure 3A wherein the manifold is shown transparent.
  • Figures 4.1-4.6 show cross section views of the manifold from the device during various stages of its operation with Figs. 4.1 to 4.3 being shown in a first plane and Figs. 4.4 to 4.6 being shown in a second plane.
  • Figure 5A shows a plan view of the mechanism used to actuate the second valve from the device;
  • Figure 5B shows a perspective view of the mechanism used to actuate the second valve from the device.
  • Figures 6A and 6B are perspective views of the whole device showing two different funnels.
  • Figure 7 shows a plinth for use with the device.
  • Figures 1A and IB show a device 10 suitable for
  • the device 10 is formed of a main housing 12 which is free standing (as best shown in Figs. 6A and 6B) defining a central cavity 14.
  • the cavity 14 defines space for receiving a removable pressurised gas cylinder 16 and a removable cartridge 18 (see Figs. 4.4 - 4.6) containing an atomisable liquid.
  • the cartridge 18 is a known component and is described, for example, in US 2013/0067656. The manner in which it operates to generate a mist is as described in that document and will not be described in detail here.
  • the cavity also contains the components from the device which are used to deliver the gas from the pressurised cylinder to the cartridge (as described below) .
  • the cavity is accessible via a lid 20 (partially shown open in Fig. 1A and best shown closed in Fig. 6A) located on the top of cavity 14, which is movable by a hinge mechanism 22 between an open position allowing access to the cavity, and a closed position where the cavity is closed.
  • the lid is closed.
  • the lid 20 comprises an opening 22 to allow atomised liquid from the cartridge to escape from the cavity when the device is in use.
  • the opening is preferably aligned above the location of the cartridge 18 within the cavity.
  • the pressurised gas cylinder 16 used in the device is generally cylindrical and contains a pressurised gas suitable for being inhaled by a user of the device.
  • Exemplary gases which are useable inside the cylinder include air, oxygen enriched air and heliox (a mixture of helium and oxygen) .
  • the cylinder is fluidly connected to a pressure
  • the pressure regulating element 24 which functions to reduce the pressure of the gas leaving the cylinder from the cylinder pressure of up to 300 Bar to a lower pressure of around 6-20 Bar.
  • the pressure regulating element may be integral with the
  • cylinder or may be connected instead to the device itself.
  • the cylinder 16 is locatable within the cavity 14 of the device and is connectable to a primary safety valve 26 on the device which is biased into an ordinarily closed
  • a force is applied to the biasing element 28 to open the valve to allow gas to pass out of the cylinder.
  • the device also includes a manifold 30.
  • the manifold comprises an inlet port 32 fluidly connected to the outlet of the primary safety valve 26.
  • the manifold also comprises a second-stage pressure regulating element 34; a first 36 and second 38 spool valve; and a gas regulating cylinder 40.
  • the cartridge 18 containing the liquid to be atomised sits on top of the gas regulating cylinder from the manifold as will be described.
  • the manifold 30 defines a flow path for the gas from the pressurised cylinder which extends from the inlet port 32, past the first 36 and second 38 spool valves, through the second-stage pressure regulating element 34, through the gas regulating cylinder 40, and out from the gas regulating cylinder 40 into the cartridge 18.
  • the first 36 and second 38 spool valves from the manifold are each biased into a closed position by a respective biasing member 42 on each of the valves in order to block the flow path as shown in Fig. 4.1.
  • the first spool valve 36 is actuatable on closure of the lid 20.
  • a downward force is applied to the head of the first spool valve 36 which displaces the valve 36 from the
  • the first spool valve 36 If the lid 20 is not closed, the first spool valve 36 is not actuated. Thus the first spool valve 36 provides a safety mechanism to prevent the escape of pressurised gas from the device when the lid is open.
  • the pressurised gas After the pressurised gas has passed the first spool valve 36 in the manifold, a portion of this gas is bled off from the flow path via an outlet port 48 in the manifold which is located downstream of the first spool valve.
  • the outlet port 48 is fluidly connected to pneumatic cylinders 46 to apply a twisting force to each collar 44 via a piston in each cylinder.
  • the collar 44 is rotated which causes an actuator connected to the collar (not shown in the Figures) to depress the second spool valve 38, allowing the unbled gas from the flow path in the manifold to pass beyond the second spool valve 38.
  • the second spool valve comprises a biasing member 42 to restore the spool valve to its initial position shown in Figure 4.1 whereby the flow path in the manifold is blocked.
  • the second spool valve 38 If no cartridge 18 is connected when the lid is closed, the second spool valve 38 is not actuated. Thus the second spool valve 38 provides a safety mechanism to prevent the escape of pressurised gas from the device when no cartridge is connected.
  • the flow path in the manifold passes into the second-stage pressure regulating element 34, which operates to reduce the pressure of the gas flowing through the manifold (around 6-20 Bar) to a lower pressure suitable for use in the cartridge.
  • the gas passing through the outlet of the second-stage pressure regulating element 34 passes through the manifold along a further flow path 50 to the gas regulating cylinder 40.
  • the purpose of the gas regulating cylinder is to
  • the gas regulating element includes a piston 52 which is moveable within a bore 54.
  • the bore includes two inlets; a first inlet 56 located on an axial wall of the bore; and a second inlet 58 located on an end wall of the cylinder.
  • a gas outlet 60 of the cylinder is reached by an L-shaped channel 62 which extends radially from an edge of the piston, through to the centre of the piston, and then up through the top face of the piston.
  • pressurised gas entering the gas regulating cylinder is initially forced through the only available inlet, i.e. the second inlet 58 (see Fig. 4.4), of the regulating cylinder.
  • the gas As the gas enters this inlet, a force is applied onto the piston 52 by the gas, forcing the piston to move up.
  • the first inlet 56 is no longer blocked by the piston 52, and the L-shaped channel from the piston is in fluid communication with the first inlet, allowing the pressurised gas to pass through the first inlet, through the L-shaped channel in the piston, and out through the outlet of the cylinder.
  • a biasing element in the form of a compression spring 64 biases the piston 52 to its first position when no force is applied onto the piston by the pressurised gas from the pressure regulating element.
  • the cartridge 18 containing atomisable liquid is located on top of the gas regulating element as shown in Figure 4.4- 4.6.
  • the cartridge is formed of a main housing which defines an interior reservoir containing atomisable liquid, such as sodium chloride containing water or hyaluronic acid.
  • the base of the cartridge which sits on the gas regulating cylinder 52, comprises a perforatable film.
  • the cartridge contains an atomiser for atomising the liquid contained in the reservoir, and an outlet located above both the
  • a plurality of frangible tabs 66 which, until they are broken, cover the outlet of the cartridge.
  • a perforating means in the form of a needle 68.
  • the needle comprises a fluid channel 70 which is fluidly connectable to the gas outlet 60 of the piston.
  • the pressurised gas passes through the L-shaped channel 62, and out through the outlet 60 of the cylinder, the gas passes through the needle and enters the cartridge. Via the atomiser located in the cartridge, the pressurised gas atomises the liquid inside the cartridge, which generates a mist which passes towards the outlet of the cartridge towards the user of the device.
  • frangible tabs 66 which block the outlet of the cartridge are designed to be broken when the cartridge 18 is twisted as described above. This is achieved by
  • the mechanism to open the outlet of the cartridge 18, to pierce its lower surface and supply it with gas are largely dictated by the requirement of the cartridge. Different mechanisms to achieve these aims may be provided
  • these operations could be carried out by the user pushing a cartridge into the end of a cylinder such that the axial movement of these components triggers the various
  • a detachable funnel 72 is supplied with the device to direct the mist exiting the device towards the user.
  • the funnel is preferably made of glass or plastic to make it easy to clean and sterilise between uses.
  • the funnel comprises a curved conical wall 74 defining a flow path for the dispensed atomised liquid from the opening 22 located on the lid to a flared upper end where the user can place their face to inhale or apply the mist.
  • the funnel has an outer skirt 76 shaped to sit on the lid flush with the base 12.
  • FIG. 7 shows a plinth 80 for use with the device.
  • the plinth is formed as a floor standing cabinet which contains a gas cylinder 82.
  • the gas cylinder is removable from the plinth by an access door 84.
  • the top surface 86 of the plinth supports the device and also contains an access port 88 for receiving a gas coupling which is fluidly connected to the cylinder 82 located inside the plinth.
  • the gas coupling fluidly connects the cylinder located in the plinth with the manifold, and ultimately the cartridge, located in the device.
  • the cylinder 82 contained within the plinth 80 has a capacity which is larger than the cylinder in the device. Accordingly, the plinth and its respective high capacity cylinder gives the user the option of a high capacity device that they can operate without needing to replace the gas cylinder 16 in the device as frequently.
  • the underside of the device includes a connection port for receiving the gas coupling of the plinth when the device is located on the plinth.
  • the connection port provides a fluid path inside the device which connects up with the inlet port of the
  • the manifold is able to receive gas from either the cylinder located in the device itself, or from the gas cylinder located in the plinth.
  • a suitable control system and set of non-return valves is provided in the device to ensure that the gas from the one of the two cylinders used is fed only into the manifold, and not into the other of the two cylinders.
  • the control system also ensures that when the device is fluidly connected to the cylinder located in the plinth, the gas from this cylinder is used in preference to any gas contained in a smaller cylinder located in the device.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Abstract

L'invention concerne un nébuliseur alimenté en gaz (10) comprenant un logement (12) pour recevoir une bouteille de gaz sous pression (16) et une cartouche (18) de liquide, le gaz sous pression étant conçu de manière à nébuliser le liquide et à disperser ce liquide sous forme de brouillard par l'intermédiaire d'un orifice de sortie (22) dans la partie supérieure du logement (12). Le nébuliseur (10) comprend également un entonnoir (72) solidarisé à la partie supérieure du logement (12), comportant une extrémité étroite et une extrémité évasée, l'extrémité étroite étant en communication directe avec l'orifice de sortie (22) dans la partie supérieure du logement (12) de telle sorte que le liquide nébulisé monte le long de l'entonnoir (72) jusqu'à l'extrémité évasée par laquelle il s'échappe de l'entonnoir (72) dans une région où un utilisateur peut présenter son visage afin d'inhaler ou d'appliquer le liquide nébulisé dispersé.
PCT/EP2015/075327 2014-10-31 2015-10-30 Nébuliseur alimenté en gaz WO2016066830A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1419458.3A GB201419458D0 (en) 2014-10-31 2014-10-31 A gas fed atomiser
GB1419458.3 2014-10-31

Publications (1)

Publication Number Publication Date
WO2016066830A1 true WO2016066830A1 (fr) 2016-05-06

Family

ID=52118543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/075327 WO2016066830A1 (fr) 2014-10-31 2015-10-30 Nébuliseur alimenté en gaz

Country Status (2)

Country Link
GB (1) GB201419458D0 (fr)
WO (1) WO2016066830A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951644A (en) * 1958-01-03 1960-09-06 Ass For Physiologic Res Inc Dispensing device
US3949743A (en) * 1973-03-19 1976-04-13 Schick Incorporated Medicated vapor production method and apparatus
US20110247610A1 (en) * 2009-02-26 2011-10-13 Acp Japan Co., Ltd. Gas mist inhaler
WO2014164175A2 (fr) * 2013-03-13 2014-10-09 Pneumoflex Systems, Llc Vaporisateur a dose mesuree

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951644A (en) * 1958-01-03 1960-09-06 Ass For Physiologic Res Inc Dispensing device
US3949743A (en) * 1973-03-19 1976-04-13 Schick Incorporated Medicated vapor production method and apparatus
US20110247610A1 (en) * 2009-02-26 2011-10-13 Acp Japan Co., Ltd. Gas mist inhaler
WO2014164175A2 (fr) * 2013-03-13 2014-10-09 Pneumoflex Systems, Llc Vaporisateur a dose mesuree

Also Published As

Publication number Publication date
GB201419458D0 (en) 2014-12-17

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