WO2016049685A1 - Dispositif d'administration servant à l'administration d'une substance thérapeutique - Google Patents

Dispositif d'administration servant à l'administration d'une substance thérapeutique Download PDF

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Publication number
WO2016049685A1
WO2016049685A1 PCT/AU2015/000596 AU2015000596W WO2016049685A1 WO 2016049685 A1 WO2016049685 A1 WO 2016049685A1 AU 2015000596 W AU2015000596 W AU 2015000596W WO 2016049685 A1 WO2016049685 A1 WO 2016049685A1
Authority
WO
WIPO (PCT)
Prior art keywords
vessel
fluid
administering device
infusion line
outlet
Prior art date
Application number
PCT/AU2015/000596
Other languages
English (en)
Inventor
Brendon VAN DEN BERG
Gilman Wong
Original Assignee
Sirtex Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2014903893A external-priority patent/AU2014903893A0/en
Application filed by Sirtex Medical Limited filed Critical Sirtex Medical Limited
Publication of WO2016049685A1 publication Critical patent/WO2016049685A1/fr
Priority to AU2017100081A priority Critical patent/AU2017100081A4/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
    • B01F35/754251—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle

Definitions

  • the invention relates generally to the field of devices for administering a therapeutic substance.
  • a specific embodiment of the invention finds particular, but not exclusive, use in the administration of a therapeutic substance to a patient.
  • a syringe In standard use, a syringe is a hand-held device that is operated manually by a person who applies pressure to the plunger, expelling the substance from the syringe outlet. In use, the outlet is connected directly to a needle or cannula, which is inserted into the patient, or indirectly to a needle or cannula via an infusion line.
  • Radioactive substance which is injected from a syringe.
  • the person for example a physician
  • administering the radioactive substance is required to manually load and operate the syringe, often exposing themselves to radiation. Repeated exposure over numerous administrations can be very harmful to the syringe operator and can lead to radiation poisoning, cancer and in some instances can lead to fatalities. Therefore, eliminating, or substantially reducing, the level of exposure of a physician to radiation is desirable.
  • the invention in its first form resides in an administering device for administering a therapeutic substance in a fluid to a patient, the administering device comprising:
  • a receiving portion arranged to receive a vessel which contains a therapeutic substance and a fluid, the vessel further being configured to be in fluid communication with an outlet in the administering device;
  • the administering device is adapted to deliver to the patient a defined amount of substance and fluid via the at least one infusion line.
  • the invention in its second form resides in an administering device for administering a therapeutic substance in a fluid to a patient, said administering device comprising:
  • a receiving portion arranged to receive a vessel that is configured to contain the therapeutic substance and the fluid, the vessel further being in fluid communication with an outlet;
  • a dispersing mechanism that is arranged to at least partially disperse the therapeutic substance in the fluid within the vessel prior to or during delivery of the therapeutic substance and the fluid to the outlet;
  • the dispersing mechanism is arranged to rotate, partially rotate or oscillate the vessel to cause the therapeutic substance to disperse in the fluid.
  • the dispersing mechanism is arranged to agitate the vessel.
  • the dispersing mechanism is further arranged to agitate the fluid within the vessel wherein agitation of the fluid within the vessel causes the therapeutic substance to disperse in the fluid.
  • the dispersing mechanism is arranged to vibrate the vessel.
  • the dispersing mechanism is adapted to disperse the therapeutic substance generally evenly or homogeneously within the vessel. This may be achieved, for example, where the dispersing mechanism further includes a motor configured to operate the dispersing mechanism. Said motor preferably operates to rotate the vessel about an axis of the vessel. That axis is desirably the longitudinal axis of the vessel.
  • the vessel is positioned in association with the dispersing mechanism in a manner that substantially prevents contaminant gases in the vessel from entering the at least one infusion line.
  • the invention also includes a swivel mechanism configured to receive the vessel and includes at least one infusion line wherein the swivel mechanism is capable of substantially independent movement of the infusion line relative to the vessel yet is adapted to maintain fluid communication between the infusion line and the vessel.
  • the swivel mechanism when present in the administering device, is preferably rotatably engaged to, and in fluid communication with, the vessel outlet.
  • the swivel mechanism is interposed between the outlet and the infusion line.
  • a swivel body of the swivel mechanism is capable of substantially independent movement relative to the vessel.
  • the swivel body receives the at least one infusion line.
  • the swivel mechanism provides a rotatable seal between the vessel and the at least one infusion line.
  • the administering device for administering a therapeutic substance in a fluid to a patient comprises:
  • a receiving portion arranged to receive a vessel configured to contain the therapeutic substance in the fluid, the vessel being in fluid communication with an outlet;
  • a dispersing mechanism that is arranged to at least partially disperse the therapeutic substance in the fluid within the vessel prior to or during delivery of the therapeutic substance and the fluid to the outlet;
  • the dispersing mechanism at least partially disperses the therapeutic substance within the fluid and the swivel mechanism facilitates substantially independent movement of the at least one infusion line relative to the vessel.
  • the invention provides an administering device for administering a therapeutic substance in a fluid to a patient, said device comprising:
  • a receiving portion arranged to receive a vessel configured to contain the therapeutic substance in the fluid, the vessel being in fluid communication with an outlet;
  • the dispensing mechanism operates via an actuator arranged to transfer the therapeutic substance and the fluid to the outlet.
  • the actuator is an electrically driven actuator or may be hydraulically operated.
  • the actuator is a linear actuator.
  • the linear actuator is operated via a gearing mechanism. In use, one revolution of the gearing mechanism transfers an amount of the therapeutic substance and the fluid from the outlet approximate to the dead volume of the infusion line.
  • the dispensing mechanism in the administering device further includes a scale configured to, in use, display the approximate combined volume of the substance and the fluid in the vessel.
  • the administering device will also include a swivel mechanism arranged to receive at least one infusion line, the swivel mechanism configured to interpose the vessel outlet and the at least one infusion line and wherein, the swivel mechanism facilitates substantially independent movement of the at least one infusion line relative to the vessel.
  • the invention provides an administering device for administering a therapeutic substance in a fluid to a patient, said device comprising:
  • a receiving portion arranged to receive a vessel configured to contain the therapeutic substance, the vessel being in fluid communication with an outlet;
  • a dispersing mechanism that is arranged to at least partially disperse the therapeutic substance in the fluid within the vessel prior to or during delivery of the therapeutic substance and the fluid to the outlet;
  • a swivel mechanism configured to form a fluid communication between the outlet and the at least one infusion line, wherein the swivel mechanism is capable of substantially independent movement of the infusion line relative to the vessel yet is adapted to maintain fluid communication between the infusion line and the vessel;
  • a dispensing mechanism that is operable to controllably transfer the therapeutic substance and the fluid from the vessel to the outlet, wherein, in use, the dispensing mechanism operates to controllably deliver an amount of the substance and the fluid to the patient via the infusion line.
  • the at least one infusion line is arranged to deliver the therapeutic substance from the outlet to the patient.
  • the at least one infusion line further includes at least one one-way valve in fluid communication with the outlet and arranged to prevent backflow of the therapeutic substance and the fluid into the vessel or into another infusion line.
  • the present invention is engineered to deliver a wide range of therapeutic substances to a patient.
  • the therapeutic substance is radioactive.
  • the radioactive substance is a plurality of radioactive microparticles.
  • the administering device may further include one or more radiation shields.
  • a shield may be manufactured from plastic like material.
  • the radiation shield is manufactured from acrylic, Perspex, PVC, polythene, polypropylene, polycarbonate, Bakelite, epoxy resin or melamine.
  • the vessel used in the administering device of the invention will be of such a configuration that it is capable of retaining a fluid without substantial leakage or loss.
  • the vessel will be adapted to hold a fluid without substantial leakage or loss.
  • the vessel is a syringe.
  • the vessel is preferably containable within a substantially transparent radiation housing.
  • a substantially transparent radiation housing may be manufactured from plastic like material.
  • the radiation shield is manufactured from acrylic, Perspex, PVC, polythene, polypropylene, polycarbonate, Bakelite, epoxy resin or melamine.
  • the invention in a further form resides in an administering device for administering a therapeutic substance in a fluid to a patient, the administering device comprising:
  • a receiving portion arranged to receive and support a vessel, the vessel containing the therapeutic substance and the fluid, the vessel further being configured to be in fluid communication with an outlet in the administering device when received in the receiving portion;
  • a means to mix the therapeutic substance and fluid therein the vessel being able to move independently of the administering device when supported therein; and wherein, in use, the means to mix the therapeutic substance and fluid is adapted to move the vessel to at least mix the therapeutic substance and the fluid prior to or during delivery of the therapeutic substance and the fluid to the outlet.
  • the resultant substance may be a suspension mixture where the therapeutic substance is dispersed within the fluid, a solution mixture where the therapeutic substance is at least partially dissolved within the fluid, or the mixture may comprise at least a portion of a new product formed from the at least partial reaction of the therapeutic substance with the fluid.
  • the means to mix the therapeutic substance and fluid is provided by a means to move the vessel.
  • the means to move the vessel may be in the form of a dispersing mechanism.
  • the dispersing mechanism may be arranged to rotate, partially rotate or oscillate the vessel to cause mixing of the therapeutic substance and the fluid.
  • the dispersing mechanism is arranged to agitate the vessel such that the fluid within the vessel causes the therapeutic substance to disperse in the fluid.
  • the means to move the vessel is in the form of a vibration mechanism.
  • the vibration mechanism may be arranged to vibrate the vessel to cause the therapeutic substance to mix with the fluid.
  • the means to mix the therapeutic substance and fluid is provided by an excitation mechanism which excites the therapeutic substance and the fluid.
  • the excitation mechanism may be provided by a heat source, a sound source, or a light source.
  • the invention in a further form resides in an administering device for administering a substance contained in a vessel to a patient, the administering device comprising: a housing for receiving and supporting the vessel therein, the housing comprising: an outlet through which the substance may pass; a movement means adapted to move the vessel relative to the housing when supported therein; an infusion line in rotatable, fluid communication with the outlet of the housing; wherein, in use, the movement means moves the vessel to mix the substance contained therein prior to or during delivery of the mixed substance, the mixed substance being delivered from the vessel through the at least one infusion line.
  • the resultant mixed substance may be a suspension mixture, where at least one product is dispersed within another product, a solution mixture, where at least one product is at least partially dissolved within another product, or the mixture may comprise a portion of a new product formed from the reaction of the at least one product with another product.
  • the means to move the vessel is in the form of a dispersing mechanism.
  • the dispersing mechanism may be arranged to rotate, partially rotate or oscillate the vessel to cause mixing of the substance.
  • the dispersing mechanism is arranged to agitate the vessel such that the fluid within the vessel causes the substance to mix.
  • the means to mix is in the form of a vibration mechanism.
  • the vibration mechanism may be arranged to vibrate the vessel to cause the substance to mix.
  • the invention in a further form resides in an administering device for administering a substance to a patient, the administering device comprising:
  • a receiving portion arranged to receive a vessel which contains a substance, the vessel being configured to be in fluid communication with an outlet in the administering device once the vessel is received in the receiving portion;
  • the administering device is adapted to deliver to the patient a defined amount of substance from the vessel to the at least one infusion line via the outlet.
  • the invention in a further form resides in an administering device for administering a therapeutic substance in a fluid to a patient, the administering device comprising:
  • a receiving portion arranged to receive a vessel which contains a therapeutic substance and a fluid, the vessel further being configured to be in fluid communication with an outlet in the administering device;
  • a swivel mechanism configured to receive the vessel and includes the at least one infusion line wherein the swivel mechanism is capable of substantially independent movement of the vessel relative to the at least one infusion line yet is adapted to maintain fluid communication between the infusion line and the vessel; wherein, in use, the administering device is adapted to deliver to the patient a defined amount of substance and fluid via the at least one infusion line.
  • the invention in a further form resides in an administering device for administering a therapeutic substance in a fluid to a patient, the administering device comprising:
  • a receiving portion arranged to receive a vessel which contains a therapeutic substance and a fluid, the vessel further being configured to be in fluid communication with an outlet in the administering device;
  • a swivel mechanism arranged to receive the at least one infusion line, the swivel mechanism configured to interpose the vessel outlet and the at least one infusion line and wherein, the swivel mechanism facilitates substantially independent movement of the at least one infusion line relative to the vessel;
  • the administering device is adapted to deliver to the patient a defined amount of substance and fluid via the at least one infusion line.
  • FIG. 1A is a perspective view of the administering device in accordance with an embodiment of the present invention depicting a receiving portion of the device engaging a syringe and a plunger receiving portion of a dispensing mechanism engaging a syringe plunger;
  • FIG. 1 B is a perspective view of the administering device in accordance with the embodiment of the present invention, depicting the receiving portion of the device engaging the syringe but with the plunger disengaged from the plunger receiving portion of the dispensing mechanism;
  • FIG. 1C is a perspective view of the administering device in accordance with the embodiment of the present invention, depicting the receiving portion of the administering device engaging the syringe and the plunger receiving portion of the dispensing mechanism engaging the syringe plunger;
  • FIG. 1 D is a perspective view of the administering device in accordance with the embodiment of the present invention depicting a swivel mechanism. The administering device has not engaged the syringe;
  • FIG. 1 E is a cutaway view of the administering device in accordance with the embodiment of the present invention, depicting the components of the mechanism and the dispensing mechanism;
  • FIG. 1 F is a perspective view of the administering device in accordance with the embodiment of the present invention, depicting an opaque radiation shield and an opaque radiation housing;
  • FIG. 2A is a perspective view of the swivel mechanism in accordance with the embodiment of the present invention.
  • FIG. 2B is a side, cutaway view of the swivel mechanism in accordance with the embodiment of the present invention with a gripping portion attached;
  • FIG. 2C is a side cut away view of the swivel mechanism in accordance with the embodiment of the present invention.
  • FIG. 2D is an exploded view of the swivel mechanism in accordance with the embodiment of the present invention.
  • An embodiment of the administering device of the present invention may be used to operate a vessel containing a therapeutic substance and deliver the therapeutic substance to a patient.
  • the therapeutic substance in a fluid
  • the therapeutic substance will be understood to be a radioactive substance or radioactive medical device, such as radioactive microspheres. It is to be understood that the following description is not to be limited to this interpretation of "therapeutic substance in a fluid”.
  • the "therapeutic substance in a fluid” could also be, for exemplary purposes only, a different radioactive substance, a chemical compound, a drug, a pharmaceutical substance, fluids for intravenous injection, or a radioactive substance, either dissolved in, or dispersed in, a liquid or gas.
  • fluid is intended to mean a substance that has no fixed shape which yields easily to external pressure, such as a gas or a liquid.
  • an embodiment of the administering device described herein is an administering device for administering a therapeutic substance in a fluid to a patient, comprising a receiving portion arranged to receive a vessel configured to contain the therapeutic substance and the fluid.
  • the vessel being in fluid communication with an outlet.
  • the administering device also includes a dispensing mechanism that is operable to controllably transfer the therapeutic substance and the fluid from the vessel to the outlet, wherein, in use, an amount of the substance and the fluid is delivered to the patient.
  • Figures 1A to 1 F show an administering device (100) as described herein comprising a device body (99), a receiving portion (102), a dispensing mechanism (104), a means to mix the therapeutic substance and the fluid, the means comprising a dispersing mechanism (106), a radiation shield (108), a swivel mechanism (200), a vessel in the form of a syringe (1 12), in this embodiment, the syringe has a plunger (1 14), a patient infusion line (116) and a scale (1 18).
  • the dispensing mechanism (104) shown in this embodiment includes a linear actuator including a manual control mechanism (120B) and a translation member (120A) wherein the translation member (120A) further includes a plunger receiving portion (122).
  • the dispersing mechanism (106) is incorporated into a wall of the administering device and is configured to receive the syringe (1 12).
  • the syringe (112) is arranged to receive and dispense the therapeutic substance.
  • the dispensing mechanism (104) engages the plunger (114) of the syringe (1 12) via the plunger-receiving portion (122) and operates the plunger (1 14) via the manual control mechanism and translation member (120B and 120A).
  • the manual control mechanism 120B
  • linear movement of the translation member (120A) operates the plunger (1 14).
  • Movement of the plunger (1 14) along the parallel axis of the syringe (1 12) transfers the substance contained within the syringe (1 12) to a syringe outlet (125) where it is then transferred to the patient infusion line (116).
  • the administering device may be used to deliver the therapeutic substance to a tumour in a patient via the patient infusion line.
  • the scale (1 18) indicates the volume of the substance contained within the syringe (1 12).
  • the syringe (1 12) is housed within a radiation housing (124), which prevents exposure of the device operator to radiation.
  • Figure 1A depicts the administering device with the dispersing mechanism (106), the dispensing mechanism (104) and the swivel mechanism (200).
  • the syringe (112) is engaged with the device body (99) via the dispersing mechanism (106) and the syringe plunger (114) is engaged with the plunger receiving portion (122) of the dispensing mechanism (104).
  • the dispensing mechanism (104) operates the syringe (1 12), causing the fluid contained within the syringe (1 12) to move to the outlet.
  • the dispersing mechanism (106) rotates the syringe (1 12) in an oscillating motion, causing the therapeutic substance in the syringe (112) to become dispersed within the fluid.
  • the swivel mechanism (200) moves substantially independently relative to the syringe (1 12) such that as the syringe (112) is oscillating, a swivel body (201 ) of the swivel mechanism (200) remains substantially stationary.
  • Figure 1 B depicts the administering device with the radiation shield (108) open for receiving the syringe (1 12).
  • the syringe (1 12) is engaged with the device via the dispersing mechanism (106).
  • the syringe (1 12) is passed through an aperture of the dispersing mechanism (106) to become engaged with the dispersing mechanism (106).
  • the syringe plunger (1 14) is not yet engaged with the dispensing mechanism (104).
  • the administering device is in the syringe loading position wherein the syringe (112) and administering device are arranged such that the syringe can be loaded with the therapeutic substance via the syringe outlet (125).
  • the plunger (114) As the substance fills the syringe (1 12), it forces the plunger (114) through the syringe barrel from a compressed configuration to an extended configuration. Once the syringe is loaded with the desired dose of the therapeutic substance, the plunger receiving portion (122) of the dispensing mechanism (104) may be placed into position in order to receive the plunger (114), as shown in Figure 1 C.
  • Figure 1 C depicts the administering device after the dispensing mechanism (104) has been placed into position and has engaged the syringe plunger (1 14) via the plunger receiving portion (122).
  • Figure 1 D depicts the administering device prior to receiving the syringe. This embodiment further shows the radiation housing (124).
  • Figure 1 E depicts a cut away view of the administering device showing the internal components of the dispersing mechanism (106), and a gearing mechanism comprising the manual control mechanism (120B) and translation member (120B).
  • Figure 1 F shows the administering device in with an radiation shield (108) and the radiation housing (124).
  • Figures 1A, 1 D and 1 F show an embodiment wherein the swivel mechanism (200) is engaged with the administering device.
  • the dispensing mechanism (104) operates the syringe (112), causing the fluid contained within the syringe (1 12) to move to the outlet.
  • the dispersing mechanism (106) rotates the syringe (1 12) in an oscillating motion, causing the therapeutic substance in the syringe (112) to become dispersed within the fluid therein.
  • the swivel mechanism (200) moves substantially independently relative to the syringe (1 12) such that as the syringe (1 12) is oscillating, the swivel body (201 ) remains substantially stationary.
  • Figures 1A to 1 F show the dispersing mechanism (106) incorporated into a wall of the administering device, when supporting the syringe ( Figures 1A to 1 C) and when not supporting the syringe ( Figures 1 D to 1 F).
  • the dispersing mechanism (106) also functions as the receiving portion (102). That is, the dispersing mechanism (106) is arranged to receive the syringe (1 12).
  • the syringe (1 12) is passed through the aperture of the dispersing mechanism (106) and engages the dispersing mechanism (106).
  • the dispersing mechanism (106) is operated by a motor (126) which causes a rotational motion of the dispersing mechanism (106) and the syringe (1 12).
  • the dispersing mechanism (106) rotates the syringe (1 12) about its longitudinal axis. In some embodiments, the rotational motion alternates between a clockwise and anticlockwise direction.
  • the vessel may have any suitable structure able to contain and dispense a therapeutic substance.
  • the vessel may be a compressible vessel wherein in use, the dispensing mechanism causes the vessel to compress which in turn causes the volume of the vessel to become reduced. This reduction in volume size forces the therapeutic substance and fluid contained within the vessel to flow to the vessel outlet wherein, in use, the therapeutic substance and the fluid are delivered to the patient via the infusion line.
  • the vessel may be a syringe or other suitable vessel, adapted to receive a dosage cartridge containing a therapeutic substance and a fluid therein.
  • the vessel may engage the dosage cartridge such that the vessel outlet is in fluid communication with the substance contained within the cartridge.
  • the therapeutic substance is dispersed within the fluid inside the dosage cartridge which, in turn, may be housed within the vessel.
  • Figures 2A to 2D show a full ( Figure 2A), cutaway ( Figures 2B and 2C) and deconstructed (Figure 2D) view of the swivel mechanism (200).
  • the swivel mechanism (200) comprises the swivel body (201 ), a swivel portion (202), a gripping portion (204), a fastening mechanism (206) extending from the swivel body (201 ), a substance mixing portion (208), the patient infusion line (1 16), in the form of a first patient infusion line (1 16'), and a second infusion line (210).
  • One or both of the second infusion line (210) and the swivel mechanism (200) may further include one-way valves (212).
  • the first infusion line may include a one-way valve.
  • the swivel mechanism (200) is rotatably engagable to, and in fluid communication with the outlet (125) of the syringe (1 12) via the swivel portion (202).
  • the gripping portion (204) provides the user with a portion to grip to facilitate attachment of the swivel portion (202) to the syringe (1 12).
  • the fastening mechanism (206) assists in securing the swivel body (201 ) relative to the device body (99).
  • the swivel portion (202) comprises a luer lock arrangement for engaging the syringe outlet (125).
  • the syringe outlet (125) Upon engagement of the syringe outlet (125) and the swivel portion (202), the syringe outlet (125) is in fluid communication with the mixing portion (208) through a fluid passage (207) whereby the fluid passage is rotatably sealed relative to the mixing portion (208).
  • the swivel portion (202) may comprise a rotatable coupling to allow the syringe outlet to rotatably and sealingly engage the fluid passage, such that the fluid passage is fixed.
  • the swivel portion (202) engages both the gripping portion (204) and the syringe outlet (125). Due to the swivel capacity of the swivel portion (202), the swivel body (201 ) is able to move substantially independently relative to the swivel portion (202) and gripping portion (204). Following on from this, the swivel body (201 ) is able to move substantially independently from the syringe (1 12) as the syringe (1 12) is rotated by the dispersing mechanism (106).
  • the swivel mechanism (200) When the swivel mechanism (200) is secured relative to the device body (99), movement of the swivel body (201 ) relative to the device body (99)is substantially inhibited by the fastening mechanism (206). In use, rotation of the syringe (1 12) by the dispersing mechanism (106) causes the swivel portion (202) and the gripping portion (204) to rotate, while the swivel body (201 ) will remain substantially stationary. Thus, in use, the swivel mechanism (200) prevents the patient infusion lines (1 16) from moving and become disengaged from the patient or from shifting to an off-target position as a result of the rotation of the syringe (1 12).
  • the second infusion line (210) may be used to co-administer at least one additional therapeutic substance to a patient other than the substance contained within the syringe (1 12).
  • the additional substance is injected into the second infusion line (210) where the substance travels to the mixing portion (208).
  • the mixing portion there is only a single patient infusion line. Therefore, in use, the substance being administered from the syringe (1 12) and the co-administered substance both enter the mixing portion (208) before being delivered to the patient via the patient infusion line.
  • the mixing of the two therapeutic substances occurs only through the physical movement of the substances as they meet at the mixing portion (208) and travel through the patient infusion line, however it will be understood that this embodiment of the invention may be used in conjunction with a mixing device to ensure a more thorough mixing of the two substances. Furthermore, it will be understood that any number of therapeutic substances can be administered to the patient simultaneously using the administering device of the present invention.
  • the dispensing mechanism (104) may be a syringe pump (104'), wherein the administering device is arranged to receive the syringe (112).
  • the syringe pump (104') may be manually operated such that when in use, the syringe pump operates the syringe (1 12).
  • the syringe (1 12) received by the administering device may be any standard or custom made syringe.
  • the syringe may include a chamber or barrel with an outlet at a first end, and an open second end arranged to receive the plunger (1 14).
  • the plunger (1 14) can be inserted into the second end of the barrel and may slidably move through the barrel.
  • the plunger (1 14) further includes a rubber piston arranged to create a fluid seal between the plunger (1 14) and the barrel of the syringe. When pressure is applied by the pump (104') to the plunger (1 14), the plunger (1 14) slidably extends parallel to the longitudinal axis of the syringe (1 12), through the barrel.
  • the piston creates a seal such that movement of the plunger (1 14) transfers the substance contained with the barrel to the outlet.
  • the syringe (1 12) may be connected at its outlet to the at least one patient infusion line (1 16) leading to the patient such that when the pump (104') is operated, the contents of the syringe (112) are transferred from the syringe (1 12), along the infusion line (116), into a patient.
  • the syringe outlet may have a slip tip, a luer lock or any other suitable form of outlet.
  • the dispensing mechanism (104) operates an actuator arranged to transfer the therapeutic substance and the fluid to the outlet.
  • the actuator may be a linear actuator such as a gear mechanism including a manual control mechanism (120B) and translation member (120A).
  • the actuator may use an alternative means to a gearing mechanism, such as an electric motor driven actuator, hydraulically driven actuator, pneumatically driven actuator, screw actuator, rack and pinion or any other mechanical actuator as would be understood by the skilled addressee.
  • a gearing mechanism such as an electric motor driven actuator, hydraulically driven actuator, pneumatically driven actuator, screw actuator, rack and pinion or any other mechanical actuator as would be understood by the skilled addressee.
  • the interface between the manual control mechanism and translation member (120A and 120B) includes gears which convert rotational motion of an operator switch, into linear motion.
  • Rotational motion applied to the manual control mechanism (120B) causes the translation member (120A) to move, thereby translating the rotational motion of the manual control mechanism (120B) into the linear motion of the translation member (120A).
  • the pump (104') is adapted such that the translation member (120A) is movable from an extreme position at a first end of the device allowing the syringe (1 12) and plunger (1 14) to take a fully extended configuration, to an opposite extreme position at the opposite (second) end of the device.
  • the pump (104') forcibly moves the plunger (1 14) along the barrel of the syringe (1 12), arranging the syringe (1 12) into a fully compressed configuration.
  • one revolution of the control mechanism (120B) may transfer an amount of the therapeutic substance and the fluid from the outlet approximate to the dead volume of the at least one infusion line (1 16).
  • the dispersing mechanism sits within the radiation housing (124).
  • a flange (128) On the end of the radiation housing, proximal to the dispensing mechanism, is a flange (128) within which the dispensing mechanism sits.
  • the dispensing mechanism (106) is adapted to freely rotate within the flange (128) and the radiation housing (124).
  • the motor (126) may be enclosed within an outer casing
  • the motor (126) may drive a rotating motion which causes the drive belt to rotate clockwise or anti-clockwise.
  • the drive belt (132) has engaged the dispensing mechanism (106)
  • the dispensing mechanism (106) is rotated by the drive belt (132).
  • the motor (126) may drive an oscillating motion which causes the drive belt (132) to rotate in alternating clockwise and anti-clockwise directions.
  • the dispensing mechanism (106) is oscillated by the drive belt (132).
  • the oscillating motion may be driven by a stepper motor.
  • rotation or oscillation of the syringe caused by the dispersing mechanism may cause the therapeutic substance to disperse in the fluid.
  • the motor (126) may operate the dispersing mechanism (106) to rotate the syringe (1 12) about an axis of the syringe (112).
  • rotation of the syringe (1 12) may occur in a clockwise direction or an anti-clockwise direction.
  • the motor (126) may also operate to oscillate the syringe (1 12) such that the rotation of the syringe (1 12) is alternated between a clockwise direction and an anti-clockwise direction.
  • the dispersing mechanism (106) is arranged to controllably rotate the syringe (1 12) about its own axis such that the contents of the syringe (1 12) are dispersed inside the syringe (1 12) prior to, and at the same time as, the substance is being transferred to the outlet where it may be administered to the patient via the patient infusion line (1 16).
  • the dispersing mechanism (106) at least partially disperses the substance contained within the syringe (1 12), allowing for the substance to be more uniformly administered to the patient.
  • the rate of oscillation of the syringe (1 12) may be manually adjusted by adjusting the settings of the dispersing mechanism (106).
  • the dispersing mechanism (106) may be operated by a driving mechanism, such as a motor (126), which may be associated with the device, or external to the device.
  • the dispersing mechanism (106) may be programmed to operate at a plurality of speeds and oscillate at a plurality of angles.
  • the syringe (1 12) may be removably engagable with the dispersing mechanism (1 12).
  • the syringe (1 12) may be positioned in a manner that substantially prevents gases in the syringe (1 12), other than the therapeutic substance or the fluid, from entering the at least one infusion line (1 16).
  • the device may include the syringe (1 12) being positioned at an angle relative to the device such that air bubbles present in the syringe (1 12) travel to the end of the syringe barrel distal to the outlet and the patient infusion line (116).
  • the device may further include a swivel mechanism (200) interposing the outlet (125) and the at least one infusion line (1 16).
  • the swivel mechanism (200) may be rotatably engagable to, and in fluid communication with, the outlet (125) of the syringe (1 12), via the swivel portion (202).
  • the swivel mechanism (200) facilitates substantially independent movement of the at least one infusion line (1 16) relative to the syringe (1 12).
  • the dispersing mechanism (106) causes the syringe (1 12) to rotate about its axis.
  • the physical exertion of the movement of the syringe (1 12) on the patient infusion line (1 16) may otherwise cause the patient infusion line (116) to move.
  • movement of the infusion line (116) may pull on a cannula inserted into the patient and as such may cause pain or dislodge the cannula.
  • the therapeutic substance may be spilled or not delivered to the target treatment area. If the therapeutic substance is harmful, any substance expelled off-target may damage healthy tissue or may spill onto the operator, or the floor, which may be potentially hazardous.
  • the patient infusion line (1 16) is connected to the syringe (1 12) via a swivel mechanism
  • the swivel portion (202) is in fluid communication with the syringe outlet (125).
  • the syringe outlet (125) engages the swivel portion (202) and the gripping portion (204) which in turn, are rotatably about the swivel body
  • the swivel portion (202) and the gripping portion (204) are also rotated.
  • the bearing (214), being rotatable about the swivel body (201 ) allows the swivel body (201 ) to move substantially independently from the rotating parts, that being the syringe (1 12), the swivel portion (202) and the gripping portion (204).
  • this embodiment prevents the infusion line (116), which is engaged with the swivel body (201 ) from disengaging from the patient due to forces imparted on it by the dispersing mechanism (106) and the rotating syringe (1 12).
  • the swivel mechanism (200) may be arranged to comprise multiple patient infusion lines (1 16) such that when in use, the therapeutic substance may be delivered to multiple sites in the patient during the same delivery.
  • the swivel mechanism is arranged to receive at least one additional substance infusion line (210) such that the swivel mechanism (200) is arranged to co-deliver at least one additional therapeutic substance not contained within the syringe (1 12) to the patient.
  • the swivel mechanism (200) includes a substance mixing portion (208) configured to mix the co-administered substances before they are transferred to the patient via the patient transfusion line (166).
  • the at least one infusion line (1 16) may further include at least one oneway valve (212) configured to prevent backflow of the therapeutic substance and the fluid into the syringe (1 12) or into another infusion line (210).
  • the device further includes a scale (1 18) configured to, in use, display the approximate combined volume of the substance and the fluid in the vessel.
  • the scale may include a graduated structure, or ruler, such that as the dispensing mechanism (104) operates the plunger (1 14), moving it along the barrel of the syringe (1 12), the operator of the dispensing mechanism (104) is able to determine from the scale (118), the volume of the substance which has been administered into the patient.
  • the graduations on the scale (1 18) may be identical to those on the syringe (1 12) so that a quantitative measure can be determined.
  • the scale (1 18) may be easily removed from the device and replaced with an alternate scale (118) corresponding to a different sized syringe (1 12) such that different sized syringes (1 12) may be employed with the same device to accommodate different doses which may be required to be administered to the patient.
  • the administering device may further include the radiation shield (108) which may encapsulate the device.
  • the radiation shield (108) may only encapsulate the syringe (1 12) containing the radioactive substance, forming the radiation housing (124) for the syringe (112).
  • the radiation shield (108) and/or radiation housing (124) may be manufactured from lead, ceramic, a composite material or plastic suitable to shield the type of radiation emission.
  • any suitable plastic may be used such as acrylic, Perspex, PVC, polythene, polypropylene, polycarbonate, Bakelite, epoxy resin or melamine.
  • the radiation shield (108) and/or radiation housing (124) may be made from a substantially transparent plastic to allow the device operator to observe the syringe (1 12) as the substance is being administered and as such can visually assess the volume of substance contained within the syringe.
  • Any suitable plastic may be used such as acrylic, Perspex, polypropylene, or polycarbonate.
  • a dispersing device for dispersing a therapeutic substance in a fluid comprising a receiving portion (102) arranged to receive a vessel, such as a syringe (1 12), configured to contain the therapeutic substance and the fluid.
  • the device further includes a dispersing mechanism (106), wherein, in use, the dispersing mechanism (106) at least partially disperses the therapeutic substance within the fluid.
  • the device is in fluid communication with an outlet
  • the device may be configured to transfer the therapeutic substance and the fluid from the syringe to the outlet, wherein, in use, an amount of the therapeutic substance and the fluid is delivered to a patient via the at least one infusion line (1 16).
  • the device may further include a dispensing mechanism (104) that is operable to controllably transfer the therapeutic substance and the fluid from the syringe (1 12) to the outlet.
  • the dispensing mechanism (104) may be a syringe pump. The pump (104') being manually operated such than when in use, the pump (104') operates the syringe (1 12).
  • the syringe (1 12) received by the device may be any standard or custom made syringe.
  • the syringe (1 12) may include a chamber or barrel with an outlet at a first end, and an open second end further arranged to receive a plunger (1 14), wherein a plunger (1 14) is inserted into the second end of the barrel such that the plunger (114) slidably moves through the barrel.
  • the plunger (1 14) further includes a piston arranged to create a fluid seal between the plunger (1 14) and the barrel of the syringe (112).
  • the plunger (1 14) When pressure is applied by the pump (104) to the plunger (1 14), the plunger (1 14) slidably extends parallel to the longitudinal axis of the syringe (1 12), through the barrel.
  • the piston creates a seal such that movement of the plunger (1 14) transfers the substance contained with the barrel to the outlet.
  • the syringe (1 12) may be connected at its outlet to at least one infusion line (1 16) leading to a patient.
  • the syringe (1 12) outlet may have a slip tip, a luer lock or any other suitable form of outlet.
  • the dispensing mechanism (104) operates an actuator arranged to transfer the therapeutic substance and the fluid to the outlet.
  • the actuator may be a linear actuator powered in a manner such as with a gear mechanism including a manual control mechanism (120B) and translation member (120A).
  • the manual control mechanism and translation member (120B and 120A) includes gears which convert rotational motion of the control mechanism (120B), into linear motion.
  • the circular gear (control mechanism; 120B) engages teeth on an internal gear.
  • Rotational motion applied to the control mechanism (120B) causes the translation member (120A) to move, thereby translating the rotational motion of the control mechanism (120B) (into the linear motion of the translation member (120A).
  • the dispensing mechanism (104) is adapted such that the translation member (120A) is movable from an extreme position at a first end of the device allowing the syringe (1 12) and plunger (114) to take a fully extended configuration, to an opposite extreme position at the opposite (second) end of the device.
  • the dispensing mechanism (104) forcibly moves the plunger (1 14) along the barrel of the syringe (1 12), arranging the syringe (1 12) into a fully compressed configuration.
  • one revolution of the control mechanism (120B) causes the gearing mechanism to operate and transfer an amount of the therapeutic substance and the fluid from the outlet approximate to the dead volume of the at least one infusion line (1 16).
  • the device may include a dispersing mechanism (106) for dispersing the therapeutic substance in the fluid.
  • the dispersing mechanism (106) may further include a motor (126) configured to rotate a vessel, such as a syringe (112). Rotation of the syringe causes the therapeutic substance to disperse in the fluid.
  • the motor (126) operates the dispersing mechanism (106) to rotate the syringe (112) about an axis of the syringe (1 12).
  • rotation of the syringe (112) may occur in a clockwise direction or an anti-clockwise direction.
  • the motor (126) may also operate to oscillate the syringe (1 12) such that the rotation of the syringe (112) is alternated between a clockwise direction and an anti-clockwise direction.
  • the dispersing mechanism (106) is arranged to controllably rotate the syringe (1 12) about its own longitudinal axis such that the contents of the syringe (1 12) are dispersed inside the syringe (1 12) prior to, and at the same time as, the substance is being transferred to the outlet where it may be administered to a patient via the patient infusion line (1 16).
  • the dispersing mechanism (106) at least partially disperses the substance contained within the syringe (1 12), allowing for the substance to be more uniformly administered to the patient.
  • the rate of oscillation of the syringe (1 12) may be manually adjusted by adjusting the settings of the dispersing mechanism (106).
  • the dispersing mechanism (106) may be operated by a driving mechanism, such as a motor (126).
  • the dispersing mechanism (106) may be programmed to operate at a plurality of speeds and oscillate at a plurality of angles.
  • the syringe (112) may be removably engagable with the dispersing mechanism (112).
  • the syringe (1 12) may be positioned in a manner that substantially prevents gases in the syringe (1 12), other than the therapeutic substance or the fluid, from entering the at least one infusion line (1 16).
  • An example of this embodiment may include the syringe (1 12) being positioned at an angle relative to the device such that air bubbles present in the syringe (112) travel to the end of the syringe barrel distal to the outlet and the patient infusion line (116).
  • the device further includes a scale (1 18) configured to, in use, display the approximate combined volume of the substance and the fluid in the vessel.
  • the scale may include a graduated structure, or ruler, such that as the dispensing mechanism (104) operates the plunger (1 14), moving it along the barrel of the syringe (1 12), the operator of the dispensing mechanism (104) is able to determine from the scale (118), the volume of the substance which has been administered into the patient.
  • the graduations on the scale (1 18) may be identical to those on the syringe (112) so that a quantitative measure can be determined.
  • the scale (1 18) may be easily removed from the device and replaced with an alternate scale (1 18) corresponding to a different sized syringe (1 12) such that different sized syringes (112) may be employed with the same device to accommodate different doses which may be required to be administered to the patient.
  • the therapeutic substance may be radioactive such as a plurality of radioactive microparticles.
  • the device may further include a radiation shield (108) which may encapsulate the device.
  • the radiation shield (108) encapsulates the syringe (1 12) containing the radioactive substance, forming a radiation housing (124) for the syringe (1 12).
  • the radiation shield (108) and/or the radiation housing(124) may be manufactured from lead, ceramic, a composite material or plastic.
  • any suitable plastic may be used such as acrylic, Perspex, PVC, polythene, polypropylene, polycarbonate, Bakelite, epoxy resin or melamine.
  • the radiation shield (108) and/or housing (124) is substantially transparent to allow the device operator to observe the syringe (1 12) as the substance is being administered and as such can visually assess the volume of substance contained within the syringe.
  • Any suitable transparent material may be used such as acrylic, Perspex, polypropylene, or polycarbonate.
  • SIRT Selective internal radiation therapy
  • SIRT Selective internal radiation therapy
  • microparticle and “microsphere” are used interchangeably and are used in the ensuing description as an example of a particulate material. However they are not intended to limit the embodiments and broader invention described herein to the administration of microspheres. A person skilled in the art will appreciate that the shape of the particulate material while preferably without sharp edges or points that could damage the patients arteries or catch in unintended locations, is not limited to spheres. Nor should the term microsphere be limited to spheres. Preferably the particulate material is substantially spherical, but need not be regular or symmetrical in shape.
  • microspheres also need not be limited to any particular form or type of microparticle. Any microparticle may be administered using the embodiments and broader invention described herein.
  • An example of a suitable microparticle may include the type capable of receiving a radionuclide such as through impregnation, absorbing, coating or more generally bonding the particles together.
  • An example of a suitable radionuclide includes yttrium-90 (Y-90).
  • the microparticles are prepared as polymeric particles or as ceramic particles (including glass).
  • microparticles or other small particles When microparticles or other small particles are administered into the arterial blood supply of a target organ, it is desirable to have them of a size, shape and density that results in the optimal homogeneous distribution within the target organ. If the microparticles or small particles do not distribute evenly, and as a function of the absolute arterial blood flow, then they may accumulate in excessive numbers in some areas and cause focal areas of excessive radiation. Dispersing Microparticles
  • SIR-Spheres® microspheres are a trademarked product and are an example of a radioactive microparticle.
  • SIR-Spheres® microspheres are polymeric particles usually dispersed in water for administration to the patient.
  • the SIR- Spheres® are not in a solution and as such, due to their weight, the SIR-Spheres® settle by gravity in the syringe as they are being administered to the patient. Consequently, uniform administration of SIR-Spheres® to the target site in the patient presents significant challenges to the clinician.
  • the administration of SIR-Spheres® to a patient requires extreme care as the SIR-Spheres® must be administered uniformly and at a constant rate in order that the SIR-Spheres® distribute themselves evenly throughout the tumour. If the radioactive SIR-Spheres® congregate in a small area of the tumour, this portion of the tumour will receive a higher dose of radiation compared to other parts of the tumour where distribution of SIR-Spheres® is sparse. This uneven distribution of radiation may lower the effectiveness of the dose as the areas of the tumour with fewer SIR-Spheres® may not receive the full radiation dose required to eliminate the tumour. In this situation, the patient may require subsequent treatment or in extreme cases, may not survive the cancer.
  • the SIR-Spheres® are not uniformly distributed within the fluid during administration, they may form pockets of high density areas which may clog the syringe or patient infusion lines, causing complications during the procedure.
  • the devices as described herein assist in controllably and uniformly administering radioactive microparticles such as SIR-Spheres® to a tumour in a patient, while limiting unnecessary exposure of radiation to the physician.
  • radioactive microparticles such as SIR-Spheres®
  • Embodiments of the device of the present invention find particular, but not exclusive use, in the delivery of radioactive microparticles to a tumour in a patient.
  • the radioactive microparticles are delivered to a physician in an ampule (dispensing vessel; 330) contained within a protective lead pot (328).
  • the physician transfers the radioactive substance from the ampule (330) to a syringe (112) which is engaged with the administration device (100).
  • the physician then activates the dispensing mechanism (104) of the administration device (100) to controllably deliver the radioactive microspheres to the patient.
  • the physician may use the administration device (100), in conjunction with the dispersing mechanism (106) to ensure a more even dispersion of the radioactive microparticles is administered to the patient.
  • the physician may also use the swivel mechanism (200) in conjunction with the dispersing mechanism (106) and the administration device (100).
  • the present invention can be used to deliver any type of fluid substance to a patient or target such as, but not limited to, saline, blood or other fluids for intra venous injection, a pharmaceutical substance or chemotherapy.
  • the device may be configured to receive any sized syringe, including but not limited to, syringes ranging in size from less than 1 ml to more than 60ml.
  • the device may also be configured to receive a bag containing fluids, for example a bag containing blood or any other fluid for intra venous injection, ranging in size from less than 100ml to more than 1 L.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne, dans sa première forme, un dispositif d'administration servant à administrer à un patient une substance thérapeutique dans un fluide, ledit dispositif d'administration comportant : (i) une partie de réception servant à recevoir un récipient qui contient une substance thérapeutique et un fluide, ledit récipient étant en outre conçu pour être en communication fluidique avec un orifice de sortie dans le dispositif d'administration ; (ii) un mécanisme ou un moyen de dispersion servant à mélanger ou à déplacer le récipient pour disperser la substance thérapeutique et le fluide dans le récipient ; et (iii) au moins un tube de perfusion qui est en communication fluidique avec le récipient par l'intermédiaire de l'orifice de sortie. En cours d'utilisation, ledit dispositif d'administration est conçu pour délivrer au patient une quantité définie de la substance et du fluide par l'intermédiaire du tube de perfusion.
PCT/AU2015/000596 2014-09-30 2015-09-30 Dispositif d'administration servant à l'administration d'une substance thérapeutique WO2016049685A1 (fr)

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AU2017100081A AU2017100081A4 (en) 2015-09-30 2017-01-23 An Administering Device for Administering a Therapeutic Substance

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AU2014903893 2014-09-30
AU2014903893A AU2014903893A0 (en) 2014-09-30 A Device For Administering A Therapeutic Substance

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Cited By (6)

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CN108704179A (zh) * 2018-05-30 2018-10-26 江苏伊度医疗科技有限公司 一种医疗用输液瓶摇匀装置
KR102526796B1 (ko) * 2022-09-30 2023-04-28 주식회사 엠씨티바이오 앰플가온식 주사기 거치대
US11904181B2 (en) 2018-05-18 2024-02-20 Bard Peripheral Vascular, Inc. Systems and methods for use of a dosimetry application software tool to customize dosimetry and sphere selection for radioembolization procedure planning
US12011552B2 (en) 2018-05-18 2024-06-18 Bard Peripheral Vascular, Inc. Dual-stage syringes for independent delivery of two or more fluids
US12090337B2 (en) 2018-05-18 2024-09-17 Bard Peripheral Vascular, Inc. Systems and methods for determining flow parameters of administered fluid from radioembolization delivery device
US12131832B2 (en) 2018-05-18 2024-10-29 Bard Peripheral Vascular, Inc. Microsphere containment systems and methods

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WO1999027981A1 (fr) * 1997-12-04 1999-06-10 Bracco Research S.A. Systeme et procede permettant d'injecter automatiquement un liquide
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US20030195463A1 (en) * 1999-03-12 2003-10-16 Trombley Frederick W. Agitation devices and dispensing systems incorporating such agitation devices
WO2004014533A1 (fr) * 2002-08-07 2004-02-19 Amersham Health As Adaptateur
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US4562829A (en) * 1983-02-28 1986-01-07 E. R. Squibb & Sons, Inc. Strontium-rubidium infusion system
WO1999027981A1 (fr) * 1997-12-04 1999-06-10 Bracco Research S.A. Systeme et procede permettant d'injecter automatiquement un liquide
US20030195463A1 (en) * 1999-03-12 2003-10-16 Trombley Frederick W. Agitation devices and dispensing systems incorporating such agitation devices
US6387077B1 (en) * 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
US6767319B2 (en) * 2001-06-29 2004-07-27 Medrad, Inc. Delivery methods, systems and components for use with hazardous pharmaceutical substances
WO2004014533A1 (fr) * 2002-08-07 2004-02-19 Amersham Health As Adaptateur

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Publication number Priority date Publication date Assignee Title
US11904181B2 (en) 2018-05-18 2024-02-20 Bard Peripheral Vascular, Inc. Systems and methods for use of a dosimetry application software tool to customize dosimetry and sphere selection for radioembolization procedure planning
US12011552B2 (en) 2018-05-18 2024-06-18 Bard Peripheral Vascular, Inc. Dual-stage syringes for independent delivery of two or more fluids
US12036373B2 (en) 2018-05-18 2024-07-16 Bard Peripheral Vascular, Inc. Catheter with flaring tip
US12090337B2 (en) 2018-05-18 2024-09-17 Bard Peripheral Vascular, Inc. Systems and methods for determining flow parameters of administered fluid from radioembolization delivery device
US12131832B2 (en) 2018-05-18 2024-10-29 Bard Peripheral Vascular, Inc. Microsphere containment systems and methods
CN108704179A (zh) * 2018-05-30 2018-10-26 江苏伊度医疗科技有限公司 一种医疗用输液瓶摇匀装置
KR102526796B1 (ko) * 2022-09-30 2023-04-28 주식회사 엠씨티바이오 앰플가온식 주사기 거치대

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