WO2016047947A3 - 광역학 치료용 테트라피라지노폴피라진 유도체 및 이의 제조방법 - Google Patents

광역학 치료용 테트라피라지노폴피라진 유도체 및 이의 제조방법 Download PDF

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Publication number
WO2016047947A3
WO2016047947A3 PCT/KR2015/009602 KR2015009602W WO2016047947A3 WO 2016047947 A3 WO2016047947 A3 WO 2016047947A3 KR 2015009602 W KR2015009602 W KR 2015009602W WO 2016047947 A3 WO2016047947 A3 WO 2016047947A3
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WO
WIPO (PCT)
Prior art keywords
photodynamic therapy
tetrapyrazinoporphyrazine derivative
preparing same
tetrapyrazinoporphyrazine
derivative
Prior art date
Application number
PCT/KR2015/009602
Other languages
English (en)
French (fr)
Other versions
WO2016047947A2 (ko
Inventor
정재윤
송철준
Original Assignee
한양대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한양대학교 산학협력단 filed Critical 한양대학교 산학협력단
Publication of WO2016047947A2 publication Critical patent/WO2016047947A2/ko
Publication of WO2016047947A3 publication Critical patent/WO2016047947A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

본 발명은 광역학 치료용 테트라피라지노폴피라진 유도체에 관한 것으로서 실리콘 테트라피라지노폴리라진 유도체의 축방향에 다양한 알코올을 치환함으로써, 용매에 따른 광학적 물성 및 용해도가 향상되었을 뿐만 아니라, 광학적 특성도 개선되어, 광역학 치료를 위한 효과적인 광감작제로 사용될 수 있다.
PCT/KR2015/009602 2014-09-25 2015-09-14 광역학 치료용 테트라피라지노폴피라진 유도체 및 이의 제조방법 WO2016047947A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0128053 2014-09-25
KR20140128053 2014-09-25

Publications (2)

Publication Number Publication Date
WO2016047947A2 WO2016047947A2 (ko) 2016-03-31
WO2016047947A3 true WO2016047947A3 (ko) 2016-09-15

Family

ID=55582203

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/009602 WO2016047947A2 (ko) 2014-09-25 2015-09-14 광역학 치료용 테트라피라지노폴피라진 유도체 및 이의 제조방법

Country Status (2)

Country Link
KR (1) KR101781598B1 (ko)
WO (1) WO2016047947A2 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04288022A (ja) * 1991-03-14 1992-10-13 Hitachi Chem Co Ltd 蛍光標識用色素を含有するガンもしくは腫瘍の体内診断薬及び治療薬
US5665875A (en) * 1992-11-10 1997-09-09 Hitachi Chemical Co., Ltd. Water-soluble tetraazaporphins and fluorochrome for labeling
KR20160044217A (ko) * 2014-10-15 2016-04-25 대화제약 주식회사 가용화된 광감작제를 유효성분으로 하는 진단 또는 치료용 약학적 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012086857A1 (ko) * 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04288022A (ja) * 1991-03-14 1992-10-13 Hitachi Chem Co Ltd 蛍光標識用色素を含有するガンもしくは腫瘍の体内診断薬及び治療薬
US5665875A (en) * 1992-11-10 1997-09-09 Hitachi Chemical Co., Ltd. Water-soluble tetraazaporphins and fluorochrome for labeling
KR20160044217A (ko) * 2014-10-15 2016-04-25 대화제약 주식회사 가용화된 광감작제를 유효성분으로 하는 진단 또는 치료용 약학적 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LI, DONG HONG ET AL.: "A Novel Chlorin-PEG-Folate Conjugate with Higher Water Solubility, Lower Cytotoxicity, Better Tumor Targeting and Photodynamic Activity", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, vol. 127, 2013, pages 28 - 37, XP028737691 *
SONG, C, J. ET AL.: "Synthesis and Characterization of Silicon Tetrapyrazinoporphyrazine substituted with PEG for PDT", THE 7TH ASIA-PACIFIC CONFERENCE ON TRANSDUCERS AND MICROLNANO TECHNOLOGIES, 29 June 2014 (2014-06-29) *
SONG, C. J.: "Synthesis and Characterization of New Porphyrazine Derivative for Bio Imaging Application", DOCTORATE THESIS, 1 August 2015 (2015-08-01), pages 1 - 178 *
WHEELER, BOB L. ET AL.: "A Silicon Phthalocyanine and a Silicon Naphthalocyanine: Synthesis, Electrochemistry, and Electrogenerated Chemiluminescence", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 106, no. 24, 1984, pages 7404 - 7410, XP002498393 *

Also Published As

Publication number Publication date
KR20160036485A (ko) 2016-04-04
WO2016047947A2 (ko) 2016-03-31
KR101781598B1 (ko) 2017-09-25

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