WO2016047754A1 - Dispositif d'inspection, fixation configurant ledit dispositif d'inspection, terminal de réseau portable, et programme de commande de terminal de réseau portable - Google Patents

Dispositif d'inspection, fixation configurant ledit dispositif d'inspection, terminal de réseau portable, et programme de commande de terminal de réseau portable Download PDF

Info

Publication number
WO2016047754A1
WO2016047754A1 PCT/JP2015/077099 JP2015077099W WO2016047754A1 WO 2016047754 A1 WO2016047754 A1 WO 2016047754A1 JP 2015077099 W JP2015077099 W JP 2015077099W WO 2016047754 A1 WO2016047754 A1 WO 2016047754A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
substance
data
communication terminal
camera
Prior art date
Application number
PCT/JP2015/077099
Other languages
English (en)
Japanese (ja)
Inventor
隆 日下
佳 平尾
Original Assignee
国立大学法人 香川大学
株式会社三紅メディカル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国立大学法人 香川大学, 株式会社三紅メディカル filed Critical 国立大学法人 香川大学
Publication of WO2016047754A1 publication Critical patent/WO2016047754A1/fr

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to an inspection apparatus used for acquiring information in a human biological tissue or other desired substance to be inspected by an optical technique, and a technology related thereto.
  • Patent Document 1 A conventional example of an inspection apparatus is described in Patent Document 1.
  • the inspection apparatus described in this document uses a so-called multipoint measurement technique, and includes first and second configurations described below.
  • one light source and two light receiving units are provided.
  • the light source is for irradiating light on the surface of the substance so that the light enters the substance to be inspected.
  • the two light receiving parts receive light that has been emitted from the light source and diffused in the substance (including diffuse reflection, the same applies hereinafter) and arrived at two places different from the light irradiation part on the surface of the substance. Set to From these two light receiving sections, signals of levels corresponding to the respective amounts of received light are output.
  • two light sources and one light receiving unit are provided.
  • two light irradiation units are set on the surface of the substance to be inspected.
  • the two light sources are individually turned on.
  • the optical characteristic information of the deep part in the substance from which the optical information of the relatively shallow part in the substance is excluded can be obtained by the same method as in the case of the first configuration described above.
  • the separation distance between the light irradiation part and the light receiving part set on the surface of the substance is set to an optimum distance so that an accurate measurement value can be obtained. If the separation distance is too short, for example, there is a problem that a large amount of reflected light (interface reflected light) from the surface of the substance reaches the light receiving portion. On the other hand, if the separation distance is too long, so-called sneak light (light transmitted through the interface region in the shallower portion than the original inspection target region and light that has passed through the shallow portion) reaches a large amount of the light receiving unit. Problems such as defects and a narrow dynamic range occur. Further, the optimum separation distance between the light irradiating unit and the light receiving unit varies depending on the inspection item.
  • the light receiving part is a dot-like region, and the distance between the light receiving part and the light irradiation part is fixed. For this reason, it is difficult to obtain an optimum distance as the separation distance and adjust to the obtained distance according to the inspection item. As a result, the measurement accuracy may be inferior, and there is still room for improvement in improving the reliability of the measurement accuracy.
  • the information on the substance surface in the plurality of light irradiation units or the plurality of light receiving units is the same.
  • information on the material surface may be different between a plurality of light irradiation sections or between a plurality of light receiving sections.
  • the examination target is a living tissue
  • An object of the present invention is to provide an inspection device capable of eliminating or reducing the above-described problems, an attachment constituting the inspection device, a portable communication terminal, and a program for controlling the portable communication terminal. There is.
  • An inspection apparatus includes a light source for irradiating light on a surface of the substance so that light is incident on the substance to be inspected, and a light source emitted from the light source to pass through the substance.
  • Light receiving means for receiving light reaching a part different from the light irradiation part on the surface of the substance by diffusing, and outputting a signal of a level corresponding to the amount of light received, and signal data output from the light receiving means
  • a data processing unit that executes a process for obtaining optical characteristic information for a specific wavelength region in the substance based on the inspection device, wherein the light receiving means is a one-dimensional or two-dimensional image.
  • the data processing unit As data for determining the optical characteristic information, is characterized in that it is configured to use the captured image data.
  • the “optical characteristic information” include an extinction coefficient, a light transmission coefficient, or a transmittance.
  • the data processing unit includes data of a diffused light receiving region in which any range of the captured image data has a linear relationship between a separation distance from the light irradiation unit and a logarithmic value of the amount of received light.
  • the optical characteristic information in the substance is obtained by using the data determined to be present and determined to be within the range of the diffused light receiving region.
  • a two-dimensional image sensor is used as the image sensor, and the data processing unit includes two-dimensional captured image data of the surface of the substance acquired by imaging using the two-dimensional image sensor. From this, data corresponding to an image of a linear area on the surface of the substance is selected, and the range of the diffused light receiving area is determined for the selected data.
  • the data processing unit determines whether or not the captured image data includes abnormal data due to non-uniformity of the surface of the substance, and the abnormal data is included. If it is determined, the optical characteristic information is determined based on the captured image data from which the abnormal data is excluded.
  • the inspection apparatus includes a portable communication terminal including a light source, a camera using an image sensor, and a control unit capable of executing data processing of a signal output from the camera, and the portable communication.
  • a portable communication terminal including a light source, a camera using an image sensor, and a control unit capable of executing data processing of a signal output from the camera, and the portable communication.
  • An attachment that can be attached to and detached from a terminal, and a light source for irradiating light on the surface of the substance, as the light receiving means and the data processing unit, a light source of the portable communication terminal,
  • a camera and a control unit are used, respectively, and the attachment sets the separation distance between the surface of the substance and the camera to be an imageable distance of the camera by contacting the surface of the substance. It has a measuring probe that can.
  • the inspection apparatus includes a portable communication terminal including a camera using an image sensor and a control unit capable of executing data processing of a signal output from the camera, and the portable communication terminal. And a removable attachment, and the light receiving means and the data processing unit are configured such that a camera and a control unit of the portable communication terminal are used, respectively.
  • the light source, and a measurement probe capable of setting a separation distance between the surface of the substance and the camera to be an imageable distance of the camera by being brought into contact with the surface of the substance.
  • the light source, the light receiving unit, and the data processing unit are incorporated in a common case, and light emitted from the light source can be guided to the surface of the substance in the case.
  • a measurement probe capable of setting the separation distance between the surface of the substance and the light receiving means to be an imageable distance by being brought into contact with the surface of the substance.
  • the measurement probe has a planar tip surface having translucency capable of pressing the entire imaging target region on the surface in a planar shape when being brought into contact with the surface of the substance. ing.
  • the inspection apparatus includes a light guide for guiding the light to the surface of the substance while suppressing the divergence of the light emitted from the light source.
  • a plurality of light irradiation units positioned around the imaging target region by the image sensor and spaced apart from each other, or an annular light irradiation unit surrounding the imaging target region can be set. Has been.
  • An inspection apparatus includes a light source for irradiating light on the surface of the substance so that the light is incident on the substance to be inspected, and a light source emitted from the light source and passing through the substance.
  • Light receiving means for receiving light reaching a part different from the light irradiation part on the surface of the substance by diffusing, and outputting a signal of a level corresponding to the amount of light received, and signal data output from the light receiving means
  • a data processing unit that executes a process for obtaining optical characteristic information for a specific wavelength region in the substance based on the inspection device, wherein the light receiving means is a one-dimensional or two-dimensional image.
  • a sensor is provided, and light that passes through the surface after reaching a part of the surface of the material at a different angle from the inside of the material is applied to each part of the image sensor for each angle of arrival at the surface.
  • a light guide member that further guides the light so as to be received separately, and that receives light as a signal output from the image sensor, and indicates a light amount distribution for each arrival angle of light reaching a part of the surface of the substance.
  • the data processing unit is configured to use the received light data as data for obtaining the optical characteristic information.
  • the attachment provided by the third aspect of the present invention is used by being attached to a camera using an image sensor and a portable communication terminal having a control unit capable of executing data processing of signals output from the camera.
  • An attachment used to construct the inspection apparatus provided by the first aspect of the present invention, the light source attached to the attachment, or emitted from the light source provided in the portable communication terminal The illumination probe unit that can irradiate the surface of the material with the light, and a part of the probe surface abuts on the surface of the material, so that the distance between the surface of the material and the camera can be imaged. And an imaging probe section for setting the distance.
  • a portable communication terminal provided by the fourth aspect of the present invention includes an operation unit, a camera using an image sensor, and a control unit capable of executing data processing of a captured image signal output from the camera.
  • a portable type that constitutes an inspection apparatus capable of executing processing for obtaining optical characteristic information about a specific wavelength region in a substance to be inspected by being used in combination with the attachment provided by the third aspect of the present invention.
  • the captured image data corresponding to the amount of light that has diffused through the substance and reached the surface of the substance by acquiring a part different from the part with the camera is obtained. From the above, picked-up image data indicating the amount of light reaching each of a plurality of pick-up points with different separation distances from the light irradiating unit, and executing the process of obtaining the optical characteristic information based on the selected data It is characterized by being configured.
  • a control program for a portable communication terminal provided by the fifth aspect of the present invention includes an operation unit, a camera using an image sensor, and a control unit capable of executing data processing of a captured image signal output from the camera.
  • a control program for a portable communication terminal used to configure an inspection device that executes processing for obtaining optical characteristic information for a specific wavelength region, when a predetermined operation is performed in the operation unit A step of setting the portable communication terminal to an inspection processing mode; and a light source attached to the attachment in the inspection processing mode.
  • the portion different from the light irradiation part on the surface of the substance is imaged by the camera,
  • a step of acquiring captured image data corresponding to the amount of light that has diffused in the material and reached the surface of the material, and a plurality of images in which the separation distance from the light irradiation unit is different from the captured image data Selecting the captured image data indicating the light arrival amount for each point, and executing the process of obtaining the optical characteristic information based on the selected data, including data for causing the control unit to execute It is characterized by being.
  • FIG. 1A is a cross-sectional side view of an essential part showing an example of an inspection apparatus according to the present invention
  • FIG. 1B is an enlarged cross-sectional view of an essential part of FIG. 1A
  • FIG. 1C is an exploded perspective view of the inspection apparatus shown in FIG.
  • FIG. 2 is a block diagram showing a hardware configuration of a portable communication terminal constituting the inspection apparatus shown in FIGS. 1A to 1C.
  • FIG. 3A is an explanatory plan view showing the relationship between the light irradiation unit and the imaging target region
  • FIG. 3B is a graph showing an example of data obtained by imaging. It is explanatory drawing which shows an example in case abnormal data exists in a captured image.
  • FIGS. 1A to 1C are explanatory diagrams showing other examples when abnormal data exists in the captured image.
  • 2 is a flowchart showing an example of a data processing procedure executed by the inspection apparatus shown in FIGS. 1A to 1C.
  • FIG. 2 is a side sectional view of an essential part showing a comparison with the inspection apparatus shown in FIGS. 1A to 1C (this comparison corresponds to an embodiment of the present invention).
  • It is a disassembled perspective view which shows the other example of the test
  • 10A is a perspective view showing another example of the inspection apparatus according to the present invention, and FIG.
  • FIG. 10B is an explanatory view schematically showing the main configuration of FIG. 10A.
  • FIG. 11A is an explanatory view schematically showing another example of the inspection apparatus according to the present invention
  • FIG. 11B is an explanatory plan view showing the relationship between the light irradiation unit and the imaging target area in the inspection apparatus shown in FIG. 11A.
  • It is. 12A is an explanatory plan view showing another example of the positional relationship between the light source and the imaging target region
  • FIG. 12B is a graph showing an example of imaging data obtained by the configuration of FIG. 12A.
  • 13A and 13B are explanatory plan views illustrating another example of the positional relationship between the light source and the imaging target region.
  • FIG. 14A is an explanatory view schematically showing another example of the main structure of the inspection apparatus of the present invention
  • FIG. 14B is an explanatory plan view showing the relationship between the light irradiation part and the imaging position in the configuration of FIG. 14A
  • FIG. 14C is a graph showing an example of imaging data obtained by the configuration of FIG. 14A.
  • the inspection apparatus E1 shown in FIGS. 1A to 1C is configured by combining a portable communication terminal B and an attachment A1 that can be attached to and detached from the portable communication terminal B.
  • This inspection device E1 is used for measuring the concentration of a specific component in a human biological tissue, for example, measuring the serum total bilirubin concentration for a liver function test.
  • the description will be made on the assumption that the substance to be examined is the living tissue 9 having the skin 90 and the subcutaneous tissue 91.
  • the type of inspection object is not limited to this, and various substances can be inspected as described later.
  • the portable communication terminal B is a smartphone, and, as shown in FIG. 2, except for the point that the inspection processing program P1 is stored in the storage unit 10a of the control unit 10, the other configurations are conventionally known smartphones. It is the same. Specifically, the portable communication terminal B includes a light source 2, a camera 3 capable of color imaging, a communication circuit 11, a liquid crystal panel, an organic EL panel, and the like in addition to the control unit 10 described above. 12, a touch panel type operation unit 13 and a speaker 14 are provided.
  • the control unit 10 executes the operation processing and data processing of each unit of the portable communication terminal B, and corresponds to an example of the data processing unit referred to in the present invention. Based on the control program P1, the serum total bilirubin concentration, etc. Data processing for obtaining the concentration of the specific component is also executed. However, the specific content will be described later.
  • the light source 2 is used for illumination during imaging by the camera 3. However, the light source 2 is also used as a light source for irradiating the surface of the skin 90 with light and making the light enter the living tissue 9 as described later.
  • the light source 2 is configured using, for example, a white LED, and is in a position relatively close to the camera 3.
  • the camera 3 corresponds to an example of the light receiving means referred to in the present invention. As will be described later, the camera 3 images the surface of the skin 90 and detects the amount of light diffused in the living tissue 9 reaching each part of the surface of the skin 90. Used to do.
  • the camera 3 is configured by combining a condenser lens 30, an RGB color filter 31, and an image sensor 32.
  • the image sensor 32 is a two-dimensional image sensor (area image sensor) such as a CCD or a CMOS, for example, and has a structure in which a large number of light receiving elements having fine light receiving surfaces are arranged vertically and horizontally.
  • the RGB color filter 31 is provided corresponding to each of a large number of light receiving surfaces of the image sensor 32, and the image sensor 32 outputs an output level (voltage) corresponding to each of the received light amounts of RGB as a captured image signal. Level) is output.
  • the RGB color filter 31 can be used as a filter for selecting light in a wavelength range necessary for inspection. For example, in the case of measuring serum total bilirubin concentration, the R signal is not used and only the G and B signals are used.
  • the analog captured image signal output from the camera 3 is amplified by the amplification unit 15, converted to a digital signal by the A / D conversion unit 16, and then input to the control unit 10.
  • attachment A1 has one corner 19 close to camera 3 and light source 2 among the four corners of portable communication terminal B as an attachment target.
  • the attachment A1 has an attachment main body 4 and a measurement probe 5.
  • the attachment main body 4 is made of resin, and has an upper wall portion 40 having an L shape in plan view and a vertical wall portion 41 connected to the upper wall portion 40.
  • the measurement probe 5 is joined to the lower portion of the vertical wall portion 41, and a recess 42 for inserting the corner portion 19 of the portable communication terminal B is provided between the measurement probe 5 and the upper wall portion 40. Is formed.
  • the measurement probe 5 has probe parts 5a and 5b for illumination and imaging.
  • the light guide 50 is provided.
  • the light guide 50 is configured using, for example, an optical fiber, an image conduit, or a mirror.
  • the light guide 50 guides light to a position closer to the probe unit 5 b than a position directly below the light source 2, and reaches the skin 90 at a position as close as possible to an imaging target region by the camera 3. It is set to emit light.
  • the imaging probe unit 5b is made of a material that transmits light in a wavelength region used for concentration measurement of a specific component, and has a flat tip surface 51. By bringing the distal end surface 51 into contact with the imaging target area of the skin 90, the imaging target area is maintained in a flat shape, and the separation distance La between the imaging target area and the camera 3 is set to the imageable distance of the camera 3. It is possible to set. If the camera 3 is very close to the skin 90 and the distance is smaller than the minimum imageable distance of the camera 3, appropriate imaging becomes difficult. On the other hand, the imaging probe unit 5b plays a role of making the separation distance La between the skin 90 and the camera 3 larger than the minimum imageable distance of the camera 3 and enabling appropriate imaging without defocusing. .
  • the surface of the skin 90 is raised by an appropriate dimension Lb, and there is a possibility that a focused captured image can be obtained.
  • the probe part 5b in this embodiment is used, such a possibility is eliminated.
  • the outer surface of the probe portion 5b has a light shielding property, and disturbance light is prevented from entering the probe portion 5b.
  • a light-shielding property is also provided between the probe unit 5b and the light guide path 50, and light from the light guide path 50 is also prevented from directly entering the probe section 5b.
  • the operation mode of the portable communication terminal B is set to the inspection processing mode (S1: YES, S2).
  • the measurement probe 5 is pressed against the skin 90 such as the human sternum or the forehead and the light source 2 is driven to turn on
  • the camera 3 is turned on and the surface of the skin 90 is imaged ( S3: YES, S4).
  • this imaging for example, as shown in FIG. 3A, two-dimensional captured image data D1 obtained by imaging an area AR1 (lattice pattern portion) adjacent to the light irradiation unit 6 in the surface of the skin 90 is obtained.
  • a circle C ⁇ b> 1 illustrated in FIG. 3A is an example of a range in which light diffuses in the living tissue 9 around the light irradiation unit 6.
  • the control unit 10 selects the captured image data D10 of the linear area AR10 from the above-described two-dimensional captured image data D1 (S5).
  • the linear region AR10 is, for example, a linear or belt-shaped region (cross-hatched portion in FIG. 3A) along the straight line SL1 that passes through the light irradiation unit 6.
  • the captured image data D10 of the linear area AR10 corresponds to data indicating the amount of light reaching each of a plurality of imaging points with different separation distances from the light irradiation unit 6.
  • G and B captured image data among the three types of RGB captured image data is used, and R captured image data is not used.
  • the picked-up image data D10 of the linear area AR10 is selected so that there is no heterogeneous portion H (see FIG. 4 and FIGS. 5A to 5C) such as a wound, mole or hair in the linear area AR10.
  • the condition is that there is no large non-uniformity on the surface of the skin 90 corresponding to AR10.
  • the heterogeneous portion H exists, the position and size can be clearly determined in the captured image data D1.
  • the captured image data of the linear area AR10 is not selected as data for obtaining the extinction coefficient. In this case, for example, as shown in FIG.
  • both or one of the linear image areas AR11 and AR12 that are offset from the straight line SL1 by an appropriate dimension Lc is selected, and the image data of the heterogeneous portion H is included. Not to be.
  • picked-up image data of a linear region AR13 extending at an appropriate angle with respect to the straight line SL1 is selected. It doesn't matter.
  • captured image data of a linear region AR14 extending in a direction orthogonal to the straight line SL1 may be selected.
  • the above-described captured image data D10 has a content as shown in FIG. 3B, for example, and overall, as the distance from the light irradiation unit 6 increases, the amount of received light (arrival light amount) tends to decrease. .
  • the control unit 10 determines the range R2 of the diffused light receiving region in which the separation distance from the light irradiation unit 6 and the logarithmic value of the amount of received light have a linear relationship, and within this range R2 Is used to obtain an extinction coefficient for a specific wavelength range from blue light to green light in the living tissue 9 (S6).
  • the range R1 close to the light irradiation unit 6 in FIG.
  • a range R3 far from the light irradiation unit 6 is a sneak light receiving region where sneak light such as subcutaneous fat conduction light arrives.
  • the data of the diffused light receiving region R2 described above is data of a region where the light diffused in the living tissue 9 has appropriately reached and does not include or hardly include the above-described interface reflected light and sneak light. It is.
  • the extinction coefficient for the specific wavelength region in the living tissue 9 When obtaining the extinction coefficient for the specific wavelength region in the living tissue 9 using the data of the diffused light receiving region R2 described above, it is optimal or close to the optimum for calculating the extinction coefficient within the range of the diffused light receiving region R2.
  • Multiple possible individual data can be selected. Specifically, for example, it is possible to select data of received light amounts a1 and a2 at two imaging points P1 and P2 in which the difference in the separation distance is close to the maximum in the diffused light receiving region R2.
  • the data to be selected is not limited to this. For example, by performing a test or the like in advance, candidates for two imaging points P1 and P2 considered to be optimal may be determined, and data corresponding to these candidates may be selected.
  • calculation processing for obtaining an extinction coefficient for the specific wavelength region in the living tissue 9 is executed based on the selected data (S7).
  • This arithmetic processing is executed using, for example, the following arithmetic expression 1.
  • D Amount of light incident on the light irradiation unit a1: Amount of light received at the first imaging point P1 a2: Amount of light received at the second imaging point P2
  • L1 First imaging point P1 from the light irradiation unit (side closer to the light irradiation unit) ) Average optical path length (average distance traveled by diffused light)
  • L2 Average optical path length from the light irradiation unit to the second imaging point P2 (on the side far from the light irradiation unit) (average value of distance traveled by diffused light) Abs 1 : Absorbance at imaging point P 1 Abs 2 : Absorbance at imaging point P 2
  • the absorbance depending on the difference in average optical path length in the light diffuser can be obtained by taking the difference in absorbance between the imaging point P1 and the imaging point P2. Since the optical path length difference in the light diffuser is known to be the largest in the deep part, the differential absorbance will contain a lot of deep part information, and the molecular species and concentration information in the deep part of the measurement object can be obtained. It becomes possible.
  • the control unit 10 After obtaining the extinction coefficient, the control unit 10 obtains the serum total bilirubin concentration in the subcutaneous tissue 91 based on the value, and displays the result on the display unit 12 (S8, S9). . Since the extinction coefficient and the serum total bilirubin concentration have a certain correspondence, the extinction coefficient can be converted to obtain the serum total bilirubin concentration.
  • the data for obtaining the extinction coefficient is optimal or close to optimal from the captured image data D10 of the skin 90 captured using the image sensor 32.
  • Data is selected and used.
  • the captured image data D10 is data indicating the amount of light reaching each of a plurality of imaging points with different separation distances from the light irradiation unit 6, the captured image data D10 is selected from the captured image data D10 according to the inspection item.
  • the captured image data D10 data that is not affected by interface reflected light or sneak light can be selected and used.
  • the data for obtaining the extinction coefficient may not include data (abnormal data) of the heterogeneous portion H such as a wound on the skin 90, a mole, or body hair. Therefore, a more appropriate value can be obtained as the extinction coefficient. As a result, it is possible to reduce the error in the measured value of the serum total bilirubin concentration obtained based on the extinction coefficient and to increase the reliability of the measured value.
  • the inspection device E1 is configured using the portable communication terminal B
  • the portable communication terminal B is not specialized as a component device of the inspection device E1, and does not interfere with daily calls or Internet connection. It is possible to use without.
  • the inspection apparatus E1 of the present embodiment has a rational configuration that effectively uses the portable communication terminal B, and the substantial system overall. The manufacturing cost can be reduced. Since not only the control unit 10 of the portable communication terminal B but also the light source 2 and the camera 3 are effectively used as components of the inspection apparatus E1, the configuration of the attachment A1 is simplified, and the overall manufacturing cost is further increased. It is possible to make it cheaper.
  • the upper wall portion 40 of the attachment A2 is substantially U-shaped in a plan view, and a lower wall portion 43 facing the upper wall portion 40 is provided below the upper wall portion 40. Between both of the measurement probe 5 and the lower wall portion 43 and the upper wall portion 40, there is provided a recess 42a into which one end portion of the portable communication terminal B and its vicinity can be fitted.
  • the attachment A2 can be attached to the portable communication terminal B by fitting one end of the portable communication terminal B and the vicinity thereof into the recess 42a. Compared with the embodiment in which the attachment A1 is attached to one corner, the attachment state of the attachment A2 can be made more stable.
  • the specific means for attaching the attachment to the portable communication terminal is not limited to the fitting method as described above, and other methods can be adopted.
  • the light source 2A is attached to the attachment A3, and the light emitted from the light source 2A can be irradiated to the skin 90.
  • the light source 2A for example, means for mounting a small-sized battery on the attachment A3 or means for receiving power supply from an output terminal provided in the portable communication terminal B is adopted. be able to.
  • the portable communication terminal B is not provided with a light source, or even if the portable communication terminal B is provided with a light source, the relative positional relationship with the camera 3 and the like. For this reason, it is possible to appropriately cope with the case where the skin 90 is not very suitable for light irradiation.
  • the inspection apparatus E4 shown in FIGS. 10A and 10B is configured as a dedicated inspection apparatus that does not use a portable communication terminal. Specifically, the data processing unit 10 ⁇ / b> A, the display unit 12, the operation unit 13, the light source 2 ⁇ / b> A, and the camera 3 using the two-dimensional image sensor are assembled in one common case 70. The measurement probe 5 is provided at a lower portion of the case 70 so as to protrude downward.
  • the inspection apparatus E4 of the present embodiment does not use a portable communication terminal
  • the basic configuration is the same as that of the inspection apparatuses E1 to E3 described above, and the intended effect of the present invention can be obtained. Is possible.
  • a one-dimensional image sensor (line image sensor) 32A is used as means for imaging the surface of the inspection target substance.
  • the region to be imaged by the one-dimensional image sensor 32A is, for example, a linear shape along a straight line SL1 passing through the light irradiation unit 6 in the region adjacent to the light irradiation unit 6 on the surface of the skin 90, as shown in FIG. 11B.
  • This area AR15 corresponds to the linear area AR10 shown in FIG. 3A. Therefore, captured image data as shown in FIG. 3B can also be obtained by imaging with the one-dimensional image sensor 32A, and the inspection processing intended by the present invention can be appropriately performed.
  • the extinction coefficient can be obtained based on the remaining data excluding the abnormal data.
  • the two light irradiation units 6 can be set on the surface of the skin 90 so as to sandwich the imaging target area AR1 by the two-dimensional image sensor.
  • the two light irradiation units 6 are arranged symmetrically with respect to the center portion Oa of the imaging target area AR1.
  • two point light sources (not shown) are used as means for enabling the two light irradiation units 6 to be set.
  • the captured image data D2 of the region along the straight line SL1 connecting the two light irradiation units 6 has contents as shown in FIG. 12B, for example.
  • the left and right ends of the imaging target area AR1 have a larger amount of received light than the center side, and the two ranges R2 in the figure represent the imaging position (separated distance from the light irradiation unit) and the received light amount.
  • the two light irradiation units 6 are set, the amount of light received by the image sensor can be increased, and the SN ratio of the captured image signal output from the image sensor can be increased.
  • the three light irradiators 6 are set at an equiangular interval around the imaging target area AR1 and set to an arrangement having rotational symmetry centered on the central portion Oa of the imaging target area AR1.
  • Such a setting can be realized by using, for example, three point light sources.
  • it can also be set as the structure which set the number of the light irradiation parts 6 to four or more.
  • an annular light irradiation unit 6a is set around the imaging target area AR1.
  • the light irradiation unit 6a is concentric with the imaging target area AR1 and has a rotational symmetry centered on the central portion Oa of the imaging target area AR1.
  • the annular light irradiation unit 6a includes an annular light scattering plate having translucency, and a plurality of point light sources for irradiating light at appropriate positions of the light scattering plate, and the light scattering plate is used as a light emitting surface. Can be set by using a light source device.
  • the amount of light applied to the skin 90 is further increased than in the embodiment shown in FIG. 12A, and the SN ratio of the captured image signal output from the image sensor is further increased. It is possible.
  • the specific number, arrangement, shape, and the like of the light irradiation section are not limited.
  • the light source a light source other than the LED light source can be used.
  • an annular light source capable of setting an annular light irradiation unit 6a as shown in FIG. 14B on the surface of the skin 90 is used.
  • a portion corresponding to the central portion of the light irradiation unit 6a is an imaging point Pa
  • a ball lens 75 is disposed on the imaging point Pa.
  • a two-dimensional image sensor 32 is disposed above the ball lens 75.
  • the ball lens 75 corresponds to an example of a light guide member in the present invention, and enters and diffuses into the living tissue 9 from the light irradiation unit 6a, and reaches the imaging point Pa at a different angle, and then the skin 90 is removed.
  • the light passing upward is guided to be distributed and received by each part of the image sensor 32 at each arrival angle ⁇ (inclination angle with respect to the normal in this specification). More specifically, light having a small arrival angle ⁇ with respect to the imaging point Pa is guided to and received at a position closer to the center of the image sensor 32, and moves closer to the end of the image sensor 32 as the arrival angle ⁇ increases. It is configured to be guided and receive light. For this reason, the image sensor 32 outputs a light reception data signal indicating a light amount distribution for each arrival angle ⁇ of the light reaching the imaging point Pa.
  • the light reception data D4 output from a plurality of light receiving elements along a straight line passing through the center of the light receiving surface of the image sensor 32 is selected from the light reception data, the light reception data D4 is as shown in FIG. 14C. Become.
  • the received light data D4 has the same property as the captured image data indicating the relative relationship between the distance from the light irradiation unit and the amount of received light shown in FIG. 12B, for example. Therefore, based on the received light data D4 shown in FIG. 14C, an extinction coefficient for a specific wavelength region in the living tissue 9 is calculated in a data processing unit (not shown), and the serum total bilirubin concentration is obtained based on the extinction coefficient. It is possible.
  • the imaging target region by the image sensor 32 can be set to only one imaging point Pa, unlike in the case of setting a plurality of imaging points, the surface information varies for each imaging point. The resulting measurement error is eliminated. More specifically, since the color of the skin 90 is not the same everywhere and varies, when a plurality of imaging points are set, one imaging point has a whiter or blackish skin than the other imaging point. Due to the above setting, there is a possibility that a difference occurs between the captured images at the two imaging points. On the other hand, according to this embodiment, the advantage by which such a concern is eliminated suitably is acquired. In the embodiment shown in FIGS. 14A to 14C, a point light source may be used as the light source, and a one-dimensional image sensor may be used as the image sensor.
  • the present invention is not limited to the contents of the above-described embodiment.
  • the specific configuration of each part of the inspection apparatus, attachment, and portable communication terminal according to the present invention can be variously modified within the scope of the present invention.
  • the specific contents of the control program according to the present invention can be variously changed within the intended scope of the present invention.
  • the case of measuring the serum total bilirubin concentration in the subcutaneous tissue of the human body has been described as a specific example.
  • the measurement target item is not limited to this, and other items can be obtained by changing the wavelength range of light. It is also possible to configure so as to measure the concentration of the specific component (for example, dissolved carbon monoxide, carbon dioxide).
  • the substance to be examined is not limited to human and animal living tissues, and various substances such as plant tissues and foods such as fruits can be examined. Therefore, the wavelength range of light used for inspection is not limited.
  • the optical characteristic information referred to in the present invention is a concept including a light transmission coefficient, a transmittance and the like in addition to an absorption coefficient.
  • the specific number of pixels, pixel density, photoelectric conversion method, and the like of the image sensor are not limited.
  • the specific type of portable communication terminal is not limited.
  • a mobile phone or a tablet terminal can be used instead of the smartphone.

Abstract

La présente invention concerne un dispositif d'inspection (E1) qui est pourvu d'un moyen de réception de lumière (3) permettant de recevoir de la lumière, qui est émise à partir d'une source lumineuse (2), s'étale dans un matériau (9) à inspecter, et, de ce fait, arrive au niveau d'une partie différente d'une unité d'irradiation de lumière (6) sur la surface du matériau (9), et de délivrer en sortie un signal ayant un niveau correspondant à la quantité de lumière reçue. Le moyen de réception de lumière (3), qui est conçu à l'aide d'un capteur d'image unidimensionnel ou bidimensionnel (32), peut capturer l'image de la surface du matériau (9) pour délivrer en sortie un signal comprenant des données d'image capturée qui indiquent une quantité d'arrivée de lumière au niveau de chaque point d'une pluralité de points de capture d'image ayant différentes distances de séparation par rapport à l'unité d'irradiation d'image (6). Les données d'image capturée sont utilisées en tant que données pour obtenir des informations de propriétés optiques à l'intérieur du matériau (9).
PCT/JP2015/077099 2014-09-26 2015-09-25 Dispositif d'inspection, fixation configurant ledit dispositif d'inspection, terminal de réseau portable, et programme de commande de terminal de réseau portable WO2016047754A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014-196382 2014-09-26
JP2014196382A JP6474148B2 (ja) 2014-09-26 2014-09-26 検査装置

Publications (1)

Publication Number Publication Date
WO2016047754A1 true WO2016047754A1 (fr) 2016-03-31

Family

ID=55581270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/077099 WO2016047754A1 (fr) 2014-09-26 2015-09-25 Dispositif d'inspection, fixation configurant ledit dispositif d'inspection, terminal de réseau portable, et programme de commande de terminal de réseau portable

Country Status (2)

Country Link
JP (1) JP6474148B2 (fr)
WO (1) WO2016047754A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3125760A4 (fr) * 2014-04-02 2017-09-06 BiliBaby, LLC Système et procédé pour déterminer les niveaux de bilirubine chez les nouveau-nés

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006098098A (ja) * 2004-09-28 2006-04-13 Sanyo Electric Co Ltd 水分センサ機能を有する携帯電話機
JP2012125370A (ja) * 2010-12-15 2012-07-05 Hitachi Ltd 生体計測装置
JP2013103094A (ja) * 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体
JP2013121420A (ja) * 2011-12-09 2013-06-20 Sony Corp 測定装置、測定方法、プログラム及び記録媒体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150168302A1 (en) * 2011-08-22 2015-06-18 Northeastern University Density analysis of living organisms by magnetic levitation
US9023295B2 (en) * 2012-12-05 2015-05-05 Promega Corporation Adapter for hand-held electronic devices for use in detecting optical properties of samples

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006098098A (ja) * 2004-09-28 2006-04-13 Sanyo Electric Co Ltd 水分センサ機能を有する携帯電話機
JP2012125370A (ja) * 2010-12-15 2012-07-05 Hitachi Ltd 生体計測装置
JP2013103094A (ja) * 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体
JP2013121420A (ja) * 2011-12-09 2013-06-20 Sony Corp 測定装置、測定方法、プログラム及び記録媒体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3125760A4 (fr) * 2014-04-02 2017-09-06 BiliBaby, LLC Système et procédé pour déterminer les niveaux de bilirubine chez les nouveau-nés
US9934589B2 (en) 2014-04-02 2018-04-03 Bilibaby, Llc System and method for determining bilirubin levels in newborn babies

Also Published As

Publication number Publication date
JP2016070666A (ja) 2016-05-09
JP6474148B2 (ja) 2019-02-27

Similar Documents

Publication Publication Date Title
KR102506587B1 (ko) 발광소자가 구비된 카메라와, 이를 이용한 피부 촬영 방법 및 피부 상태 측정 방법
JP6639549B2 (ja) 効率的変調撮像
KR101799184B1 (ko) 피부 다중 분광 이미징을 위한 모바일 기기 부착형 조명 장치
US8535221B2 (en) Electronic endoscope system and method for obtaining vascular information
RU2763756C1 (ru) Получение изображений для использования при определении одного или более свойств кожи субъекта
WO2015133456A1 (fr) Système d'examen biochimique
US9531950B2 (en) Imaging system and imaging method that perform a correction of eliminating an influence of ambient light for measurement data
JP2016154648A (ja) 情報取得装置
WO2013073245A1 (fr) Dispositif biométrique, procédé biométrique, programme et support d'enregistrement
WO2015102102A1 (fr) Système d'analyse, dispositif d'assistance à l'analyse composant celui-ci, terminal de communication mobile, et programme de commande pour terminal de communication mobile
US20120092471A1 (en) Endoscopic device
US9714865B2 (en) Light condensing unit, light condensing method, and optical detection system
CA3230185A1 (fr) Systemes, dispositifs et procedes d'imagerie et de mesure
WO2016047754A1 (fr) Dispositif d'inspection, fixation configurant ledit dispositif d'inspection, terminal de réseau portable, et programme de commande de terminal de réseau portable
JP6096173B2 (ja) 高発光光束コリメート照明装置および均一な読取フィールドの照明の方法
US11026581B2 (en) Optical probe for detecting biological tissue
JP2015029168A (ja) 電子ミラー装置
JP2006071589A (ja) 色測定装置及び光源装置
JP2017009398A (ja) 光学式生体情報測定装置および生体情報測定方法
JP2016150130A (ja) 情報取得装置および情報取得方法
JP6948069B2 (ja) 脂質計測装置及びその方法
JP2015150186A (ja) 生体光計測装置
JP2016106660A (ja) 生体情報取得装置および生体情報取得方法
JP2009222607A (ja) 試料分析装置の照明制御方法および試料分析装置
JP2016106870A (ja) 生体情報取得装置および生体情報取得方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15845474

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15845474

Country of ref document: EP

Kind code of ref document: A1