WO2016037588A3 - 用于合成抗艾滋病药物增强剂cobicistat的中间体 - Google Patents
用于合成抗艾滋病药物增强剂cobicistat的中间体 Download PDFInfo
- Publication number
- WO2016037588A3 WO2016037588A3 PCT/CN2015/089406 CN2015089406W WO2016037588A3 WO 2016037588 A3 WO2016037588 A3 WO 2016037588A3 CN 2015089406 W CN2015089406 W CN 2015089406W WO 2016037588 A3 WO2016037588 A3 WO 2016037588A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cobicistat
- synthesis
- aids drug
- drug enhancer
- disclosed
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
提供一种用于合成抗艾滋病药物增强剂cobicistat的中间体化合物I及其合成方法。还提供用该化合物I合成 (2R, 5R)-1, 6-二苯基-2, 5-己二胺的方法,该方法步骤短、条件简单易操作,生产成本低,且产品纯度高。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410466139.5 | 2014-09-12 | ||
CN201410466139.5A CN104193643B (zh) | 2014-09-12 | 2014-09-12 | 用于合成抗艾滋病药物增强剂cobicistat的中间体 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016037588A2 WO2016037588A2 (zh) | 2016-03-17 |
WO2016037588A3 true WO2016037588A3 (zh) | 2016-05-26 |
Family
ID=52079055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2015/089406 WO2016037588A2 (zh) | 2014-09-12 | 2015-09-11 | 用于合成抗艾滋病药物增强剂cobicistat的新中间体 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN104193643B (zh) |
WO (1) | WO2016037588A2 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193643B (zh) * | 2014-09-12 | 2016-02-10 | 宁波九胜创新医药科技有限公司 | 用于合成抗艾滋病药物增强剂cobicistat的中间体 |
CN105017082B (zh) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | 一种心衰药Entresto 关键中间体(R)‑叔丁基 (1‑([1,1`‑联苯]‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法 |
CN109912426B (zh) * | 2017-12-13 | 2023-01-13 | 上海奥博生物医药股份有限公司 | 用于合成抗艾滋病药物增强剂可比司他(cobicistant)的中间体 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012045007A1 (en) * | 2010-10-01 | 2012-04-05 | Gilead Sciences, Inc. | Method of preparation of (4 - {4 -acetylamino- 2 - [3- ( 2 - isopropyl - thiazol - 4 - ylmethyl) - 3 -methyl - ureido] - butyryl amino} -1 -benzyl- 5 -phenyl- pentyl) -carbamic acid thiazol - 5 - ylmethyl ester |
CN102438982A (zh) * | 2009-04-03 | 2012-05-02 | 吉里德科学公司 | 用于制备细胞色素p450单加氧酶抑制剂的方法和所涉及的中间体 |
WO2013116715A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Methods and intermediates for preparing pharmaceutical agents |
US20140051888A1 (en) * | 2012-08-20 | 2014-02-20 | Ampac Fine Chemicals Llc | Novel stereoisomeric mixtures, synthesis and uses thereof |
CN104193643A (zh) * | 2014-09-12 | 2014-12-10 | 宁波九胜创新医药科技有限公司 | 用于合成抗艾滋病药物增强剂cobicistat的新中间体 |
-
2014
- 2014-09-12 CN CN201410466139.5A patent/CN104193643B/zh active Active
-
2015
- 2015-09-11 WO PCT/CN2015/089406 patent/WO2016037588A2/zh active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102438982A (zh) * | 2009-04-03 | 2012-05-02 | 吉里德科学公司 | 用于制备细胞色素p450单加氧酶抑制剂的方法和所涉及的中间体 |
WO2012045007A1 (en) * | 2010-10-01 | 2012-04-05 | Gilead Sciences, Inc. | Method of preparation of (4 - {4 -acetylamino- 2 - [3- ( 2 - isopropyl - thiazol - 4 - ylmethyl) - 3 -methyl - ureido] - butyryl amino} -1 -benzyl- 5 -phenyl- pentyl) -carbamic acid thiazol - 5 - ylmethyl ester |
WO2013116715A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Methods and intermediates for preparing pharmaceutical agents |
US20140051888A1 (en) * | 2012-08-20 | 2014-02-20 | Ampac Fine Chemicals Llc | Novel stereoisomeric mixtures, synthesis and uses thereof |
CN104193643A (zh) * | 2014-09-12 | 2014-12-10 | 宁波九胜创新医药科技有限公司 | 用于合成抗艾滋病药物增强剂cobicistat的新中间体 |
Non-Patent Citations (2)
Title |
---|
XU, LIANHONG ET AL.: "A Novel and Efficient Synthesis of Chiral C2-Symmetric 1, 4-Diamines", TETRAHEDRON LETTERS, vol. 50, no. 5, 24 November 2008 (2008-11-24), pages 552 - 554, XP025799917, DOI: doi:10.1016/j.tetlet.2008.11.071 * |
XU, LIANHONG ET AL.: "Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 5, 17 May 2010 (2010-05-17), pages 209 - 213, XP009156835, DOI: doi:10.1021/ml1000257 * |
Also Published As
Publication number | Publication date |
---|---|
WO2016037588A2 (zh) | 2016-03-17 |
CN104193643B (zh) | 2016-02-10 |
CN104193643A (zh) | 2014-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2015145415A3 (en) | Ibrutinib solid forms and production process therefor | |
MX2018002402A (es) | Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4). | |
WO2015110897A3 (en) | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof | |
WO2016007617A3 (en) | Pharmaceutical compounding kit | |
MX2011008946A (es) | Un complejo de haluro de hidrogeno de agomelatina y la preparacion del mismo. | |
MX2019003818A (es) | Metodo para la sintesis de derivado de 3-fenil-2,3,4,8,9,10-hexahi dropiran [2,3-f] cromeno e isomero optico del mismo. | |
MY181641A (en) | Amino pyran ring derivative and composition and use thereof | |
WO2016100732A3 (en) | Commercially viable synthesis of cantharidin and bioactive cantharidin derivatives | |
WO2016179184A3 (en) | Enantioselective syntheses of heteroyohimbine natural product intermediates | |
WO2016207914A3 (en) | Methods for preparing oltipraz | |
WO2015159275A3 (en) | An improved process for the preparation of rifamycin derivatives | |
WO2016024286A3 (en) | An improved process for synthesis of lenalidomide | |
WO2017205964A8 (en) | Aminosteroid derivatives and process for producing same | |
WO2016037588A3 (zh) | 用于合成抗艾滋病药物增强剂cobicistat的中间体 | |
WO2015120111A3 (en) | Expedient synthesis of sitagliptin | |
WO2015181802A3 (en) | Oral pharmaceutical composition of isotretinoin | |
WO2016056022A3 (en) | Intermediates and processes to prepare anidulafungin | |
WO2016056023A3 (en) | Intermediates and processes to prepare micafungin | |
WO2017098533A3 (en) | Process for preparation of lisdexamphetamine | |
WO2017056013A3 (en) | Modified wood product and a process for producing said product | |
WO2016014864A8 (en) | Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof | |
EP3658553A4 (en) | NEW INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF AMINOPYRIMIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PROCESS FOR THE PRODUCTION OF AMINOPYRIMIDE DERIVATIVES USING THE SAME | |
WO2015087343A3 (en) | An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof | |
WO2017214423A3 (en) | Derivatives of thailanstatin a, methods of treatment and methods of synthesis thereof | |
WO2017046816A3 (en) | Process for the preparation of derivatives of benzodioxole |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 15840197 Country of ref document: EP Kind code of ref document: A2 |