WO2016036999A1 - Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin - Google Patents

Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin Download PDF

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Publication number
WO2016036999A1
WO2016036999A1 PCT/US2015/048422 US2015048422W WO2016036999A1 WO 2016036999 A1 WO2016036999 A1 WO 2016036999A1 US 2015048422 W US2015048422 W US 2015048422W WO 2016036999 A1 WO2016036999 A1 WO 2016036999A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
pterostilbene
topical
loss
barrier function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/048422
Other languages
English (en)
French (fr)
Inventor
Frank L. Meyskens
Ryan W. DELLINGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP15838274.7A priority Critical patent/EP3194032B1/en
Priority to JP2017512286A priority patent/JP2017525738A/ja
Priority to CA2959756A priority patent/CA2959756C/en
Priority to CN201580059094.2A priority patent/CN107106877A/zh
Priority to MX2017002818A priority patent/MX375612B/es
Priority to BR112017004304-1A priority patent/BR112017004304B1/pt
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Priority to KR1020177009080A priority patent/KR20170045343A/ko
Priority to AU2015311799A priority patent/AU2015311799A1/en
Publication of WO2016036999A1 publication Critical patent/WO2016036999A1/en
Priority to ZA2017/01510A priority patent/ZA201701510B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • a method of treating, inhibiting or preventing UV-mediated loss of barrier function in human skin comprising administering to the individual in need of such treatment an effective amount of the compound pterostilbene (e.g., by topical administration).
  • pterostilbene When pterostilbene is used in a chemopreventive method, susceptible skin is treated prior to any visible condition affecting that skin (or, in some embodiments, any other evidence of loss of barrier function) in a particular individual.
  • pterostilbene When pterostilbene is used to inhibit any of the conditions described above, pterostilbene may be applied to skin that exhibits evidence of one or more of these conditions or skin that exhibits no such evidence.
  • pterostilbene When pterostilbene is used to treat any of the conditions described above, pterostilbene may be applied to skin that exhibits evidence of one or more of these conditions. Treatment of all skin can be achieved by systemic administration.
  • Gel preparations may be in the form of a single-phase gel in which the active or medicinal ingredients are uniformly dispersed throughout the liquid vehicle without visible boundaries or a two-phase gel wherein flocculants or small distinct particles of the active or medicinal ingredient are dispersed within the liquid vehicle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
PCT/US2015/048422 2014-09-04 2015-09-03 Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin Ceased WO2016036999A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2017512286A JP2017525738A (ja) 2014-09-04 2015-09-03 皮膚におけるバリア機能のｕｖ誘導性喪失の処置に使用される局所プテロスチルベン組成物
CA2959756A CA2959756C (en) 2014-09-04 2015-09-03 Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin
CN201580059094.2A CN107106877A (zh) 2014-09-04 2015-09-03 用于治疗uv诱发的皮肤屏障功能受损的局部用蝶芪组合物
MX2017002818A MX375612B (es) 2014-09-04 2015-09-03 Composiciones tópicas de pterostilbeno para utilizarse en el tratamiento de la pérdida inducida por uv de la función de barrera en la piel.
BR112017004304-1A BR112017004304B1 (pt) 2014-09-04 2015-09-03 uso de pteroestilbeno para prepação de composições tópicas no tratamento de perda de função de barreira na pele induzidas por uv
EP15838274.7A EP3194032B1 (en) 2014-09-04 2015-09-03 Topical pterostilbene compositions for use in treating loss of barrier function in skin in burn injurys
KR1020177009080A KR20170045343A (ko) 2014-09-04 2015-09-03 피부의 장벽 기능의 ｕｖ-유도 상실을 치료하는데 사용하기 위한 국소 프테로스틸벤 조성물
AU2015311799A AU2015311799A1 (en) 2014-09-04 2015-09-03 Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin
ZA2017/01510A ZA201701510B (en) 2014-09-04 2017-02-28 Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462046068P 2014-09-04 2014-09-04
US62/046,068 2014-09-04

Publications (1)

Publication Number Publication Date
WO2016036999A1 true WO2016036999A1 (en) 2016-03-10

Family

ID=55436471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/048422 Ceased WO2016036999A1 (en) 2014-09-04 2015-09-03 Topical pterostilbene compositions for use in treating uv-induced loss of barrier function in skin

Country Status (11)

Country Link
US (1) US9980924B2 (https=)
EP (1) EP3194032B1 (https=)
JP (1) JP2017525738A (https=)
KR (1) KR20170045343A (https=)
CN (1) CN107106877A (https=)
AU (1) AU2015311799A1 (https=)
BR (1) BR112017004304B1 (https=)
CA (1) CA2959756C (https=)
MX (1) MX375612B (https=)
WO (1) WO2016036999A1 (https=)
ZA (1) ZA201701510B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9980924B2 (en) 2014-09-04 2018-05-29 The Regents Of The University Of California Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin
US12485085B2 (en) 2019-12-30 2025-12-02 Rodan & Fields, Llc PPAR agonist complex and methods of use

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101932877B1 (ko) * 2016-08-17 2018-12-26 토모이케 인더스트리얼 (에이치.케이.) 리미티드 프테로스틸벤 배당체를 포함하는 외용 조성물
JP7061766B2 (ja) * 2017-09-20 2022-05-02 学校法人同志社 Ｄｊ－１タンパク質産生促進用組成物
EP4029496A1 (en) * 2021-01-18 2022-07-20 Universitat de València Pterostilbene and silibinin for preventing, ameliorating or reducing radiation-induced diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183400A1 (en) * 2001-02-21 2002-12-05 L'oreal Composition for topical application comprising at least one hydroxystilbene and at least one polyol to solubilize the hydroxystilbene
US20090047309A1 (en) 2007-08-13 2009-02-19 Maes Daniel H Cosmetic methods and compositions for repairing human skin
WO2011005406A2 (en) 2009-06-23 2011-01-13 Elc Management Llc Skin repair compositions comprising circadian gene activators and a synergistic combination of sirt1 gene activators
US20130136778A1 (en) 2009-10-30 2013-05-30 Green Molecular, S.L. Pterostilbene (pter) for use in the prevention and/or treatment of skin diseases, damages or injuries
CN103239540A (zh) 2013-04-03 2013-08-14 广东药学院 一种凉血愈伤方提取物及治疗皮肤烧伤的复方白藜芦醇凉血愈伤油制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100240767A1 (en) * 2009-03-23 2010-09-23 Muhammed Majeed Melanogenesis inhibitiuon by 3,5-dimethoxy-4'-hydroxystilbenes and cosmeceutical compositions thereof
US8841350B2 (en) * 2011-05-11 2014-09-23 ChromaDex Inc. Method for inducing UDP-glucuronosyltransferase activity using pterostilbene
JP2013075851A (ja) * 2011-09-30 2013-04-25 Fujifilm Corp 皮膚外用剤
US20130296440A1 (en) 2012-05-01 2013-11-07 ChromaDex Inc. Pterostilbene and curcumin combination for treatment of oxidative stress and inflammation
CN107106877A (zh) 2014-09-04 2017-08-29 加利福尼亚大学董事会 用于治疗uv诱发的皮肤屏障功能受损的局部用蝶芪组合物
US20160067193A1 (en) 2014-09-04 2016-03-10 The Regents Of The University Of California Topical pterostilbene compositions for use in treating uv-induced skin damage and hyperplasia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183400A1 (en) * 2001-02-21 2002-12-05 L'oreal Composition for topical application comprising at least one hydroxystilbene and at least one polyol to solubilize the hydroxystilbene
US20090047309A1 (en) 2007-08-13 2009-02-19 Maes Daniel H Cosmetic methods and compositions for repairing human skin
WO2011005406A2 (en) 2009-06-23 2011-01-13 Elc Management Llc Skin repair compositions comprising circadian gene activators and a synergistic combination of sirt1 gene activators
US20130136778A1 (en) 2009-10-30 2013-05-30 Green Molecular, S.L. Pterostilbene (pter) for use in the prevention and/or treatment of skin diseases, damages or injuries
CN103239540A (zh) 2013-04-03 2013-08-14 广东药学院 一种凉血愈伤方提取物及治疗皮肤烧伤的复方白藜芦醇凉血愈伤油制剂

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CICHOCKI, M.: "Pterostilbene is equally potent as resveratrol in inhibiting 12-0-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis", MOL. NUTR. FOOD RES., vol. 52, no. 1, 2008, pages 62 - 70
FEDDI ET AL.: "Pterostilbene, a natural polyphenol, elicits full protection against ultraviolet B radiation-induced skin carcinogenesis: Preclinical studies", CANCER RESEARCY, vol. 71, no. 4239, 15 April 2011 (2011-04-15), XP055269350 *
HOUGEE, S.: "Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers", PLANTA MED., vol. 71, 2005, pages 387 - 92
RICHE, D.M. ET AL.: "Analysis of safety from a human clinical trial with pterostilbene", J. TOXICOL., vol. 2013, 2013, pages 463595
See also references of EP3194032A4

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9980924B2 (en) 2014-09-04 2018-05-29 The Regents Of The University Of California Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin
US12485085B2 (en) 2019-12-30 2025-12-02 Rodan & Fields, Llc PPAR agonist complex and methods of use

Also Published As

Publication number Publication date
BR112017004304A2 (pt) 2017-12-05
EP3194032A4 (en) 2018-05-23
KR20170045343A (ko) 2017-04-26
CA2959756A1 (en) 2016-03-10
BR112017004304B1 (pt) 2020-12-08
US20160067194A1 (en) 2016-03-10
US9980924B2 (en) 2018-05-29
MX375612B (es) 2025-03-06
EP3194032B1 (en) 2021-06-23
MX2017002818A (es) 2017-08-02
EP3194032A1 (en) 2017-07-26
CN107106877A (zh) 2017-08-29
AU2015311799A1 (en) 2017-03-30
JP2017525738A (ja) 2017-09-07
ZA201701510B (en) 2018-11-28
CA2959756C (en) 2023-02-28

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