WO2016025010A8 - A novel broad-spectrum antiviral synergistic pharmaceutical composition for the treatment and prevention of viral infections - Google Patents

A novel broad-spectrum antiviral synergistic pharmaceutical composition for the treatment and prevention of viral infections Download PDF

Info

Publication number
WO2016025010A8
WO2016025010A8 PCT/US2014/068451 US2014068451W WO2016025010A8 WO 2016025010 A8 WO2016025010 A8 WO 2016025010A8 US 2014068451 W US2014068451 W US 2014068451W WO 2016025010 A8 WO2016025010 A8 WO 2016025010A8
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
tetracycline
prevention
treatment
viral infections
Prior art date
Application number
PCT/US2014/068451
Other languages
French (fr)
Other versions
WO2016025010A1 (en
Inventor
Martin UGWU
Original Assignee
Ugwu Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ugwu Martin filed Critical Ugwu Martin
Publication of WO2016025010A1 publication Critical patent/WO2016025010A1/en
Publication of WO2016025010A8 publication Critical patent/WO2016025010A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms

Abstract

A broad-spectrum antiviral synergistic pharmaceutical drug composition consisting of a Tetracycline anti-infective agent (doxycycline, minocycline, tetracycline or other derivatives) and Garlic (Allium sativum) extracts (tablets, capsules, mixtures) or aged or fresh bulbs, for the treatment and prevention of viral infections caused by Filoviruses (Ebola Virus & Marburg Virus) and Retroviruses (Human Immunodeficiency Viruses (HIV-1 and HIV-2) is presented. This present invention highlights drug combinations between a tetracycline (doxycycline, minocycline, tetracycline or other derivatives) and Garlic (Allium sativum) extract (tablets, capsules, mixtures) or bulbs, each drug having potent antiviral activities whose combined effect results in synergistic therapeutic effect which is far greater than their additive effects against Filoviruses (Ebola Virus & Marburg Virus) and Retroviruses (Human Immunodeficiency Viruses (HIV-1 and HIV-2).
PCT/US2014/068451 2014-08-14 2014-12-03 A novel broad-spectrum antiviral synergistic pharmaceutical composition for the treatment and prevention of viral infections WO2016025010A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462037477P 2014-08-14 2014-08-14
US201462037490P 2014-08-14 2014-08-14
US62/037,477 2014-08-14
US62/037,490 2014-08-14

Publications (2)

Publication Number Publication Date
WO2016025010A1 WO2016025010A1 (en) 2016-02-18
WO2016025010A8 true WO2016025010A8 (en) 2016-05-06

Family

ID=55304475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/068451 WO2016025010A1 (en) 2014-08-14 2014-12-03 A novel broad-spectrum antiviral synergistic pharmaceutical composition for the treatment and prevention of viral infections

Country Status (1)

Country Link
WO (1) WO2016025010A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081634A2 (en) * 2018-10-16 2020-04-23 George Mason Research Foundation, Inc. Compositions and methods for modulation of extracellular vesicle release and treatment of neurological disorders
WO2021163451A1 (en) * 2020-02-14 2021-08-19 Asklepios Biopharmaceutical, Inc. Method of treating gene therapy associated toxicity with antibiotics
WO2021231314A1 (en) * 2020-05-11 2021-11-18 Paratek Pharmaceuticals Inc. Methods of treating covid-19 using tetracycline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US20070292355A1 (en) * 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof

Also Published As

Publication number Publication date
WO2016025010A1 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
MX2019009443A (en) Methods of treating influenza.
MD3294738T2 (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
CL2019003309A1 (en) Substituted indoline derivatives as dengue virus replication inhibitors.
CL2019002745A1 (en) Substituted indoline derivatives as dengue virus replication inhibitors.
CY1122792T1 (en) MONO-OR DISUBTITUTED INDOLE DERIVATIVES AS DANGE VIRUS REPLICATION INHIBITORS
PH12015502539B1 (en) Cenicriviroc compositions and methods of making and using the same
CL2019002744A1 (en) Substituted indoline derivatives as dengue virus replication inhibitors.
WO2017083304A8 (en) Therapeutic compositions for treatment of human immunodeficiency virus
CO2018008421A2 (en) Indoline derivatives substituted as inhibitors of dengue viral replication
CL2019003294A1 (en) Substituted indoline derivatives as dengue virus replication inhibitors.
CR20180493A (en) INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE
CU20170109A7 (en) DERIVATIVE OF QUINOLEINE TO TREAT AND PREVENT VIRAL INFECTIONS
EP3757105A3 (en) Polycyclic pyridone derivative having integrase inhibitory activity
MX2017003928A (en) Long acting pharmaceutical compositions.
PH12019550039A1 (en) Dihydropyrimidine compound and preparation method and use thereof
WO2016025010A8 (en) A novel broad-spectrum antiviral synergistic pharmaceutical composition for the treatment and prevention of viral infections
CO2018014217A2 (en) Pharmaceutical compositions comprising safinamide
CL2020001353A1 (en) Pyrazolopyrimidines that have anti-vsr activity.
PH12017501943B1 (en) Influenza virus neutralizing peptidomimetic compounds
JOP20200005A1 (en) Pharmaceutical compositions
MX2020004403A (en) Pharmaceutical compositions comprising safinamide.
WO2018084817A3 (en) A new form of active agent
BR112016028616A2 (en) hepatitis c virus inhibiting compounds, pharmaceutical compositions and uses thereof
TH168085B (en) Preparations of a pharmaceutical combination containing HMG-coeridectase inhibitors and cholesterol absorption inhibitors.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14899738

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase in:

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112 (1) EPC

122 Ep: pct application non-entry in european phase

Ref document number: 14899738

Country of ref document: EP

Kind code of ref document: A1