WO2016024720A1

WO2016024720A1 - Mobile or portable electrospinning apparatus

Info

Publication number: WO2016024720A1
Application number: PCT/KR2015/007135
Authority: WO
Inventors: 박종철
Original assignee: 박종철
Priority date: 2014-08-13
Filing date: 2015-07-09
Publication date: 2016-02-18

Abstract

The present invention relates to a mobile or portable electrospinning apparatus which can be applied to: life science fields for a delivery body, which delivers a drug to an affected area of a patient, a hemostatic agent, and wound dressing; medical fields comprising tissue engineering fields for regeneration of skin, bone, and the like, as well as a 3D support for regeneration of blood vessels, bone/cartilage, and a membrane for skin; cosmetic fields for skin cleansing, skin healing, a skin therapy, a skin mask, and the like for the skin and body; and various industry fields in which filter materials are used. Also, the electrospinning apparatus can be applied to various fields since the moving and handling of same are convenient and easy.

Description

[Revision 24.07.2015 under Rule 26] Portable or portable electrospinning apparatus

The present invention relates to an electrospinning apparatus, and more particularly, it is easy to move and handle the life science field and the skin, blood vessels, bone / cartilage regeneration to perform the carrier, hemostatic agent and wound dressing to deliver the drug to the human body It can be applied to medical fields including tissue engineering applied to three-dimensional scaffolds, cosmetic fields such as skin cleansing, skin healing, skin therapy, skin mask, and various industrial sites requiring nanofiber web of filter material. It relates to a portable electrospinning apparatus.

With the development of the textile industry, research and development for applying and fusing manufactured textile products to the IT (Information Technology) industry is increasing, and one of these textile products is a nanofiber manufactured by an electrospinning apparatus.

As such, the nanofibers manufactured by the electrospinning device have a very simple structure compared to the equipment and apparatus for manufacturing other fiber products, and the electrospinning of polymer materials is possible to add various structures and versatility. As a result, various researches are being conducted to utilize them.

Here, nanofibers (Nano Fiber) refers to microfibers (Super Fiber: Super Fiber: only a few tens to hundreds of nanometers in diameter, is produced by the electric field by electrospinning. That is, the nanofibers are subjected to a high voltage electric field applied to the polymer material as a raw material to generate an electric repulsion inside the polymer material as a raw material, and thus the molecules are agglomerated into nano-sized yarn to produce and produce the nanofibers.

In this case, the stronger the electric field, the thinner the polymer material as a raw material is, so that the nanofibers having a fineness of 10 to 1000 nm can be obtained.

As described above, the electrospinning device as shown in FIG. 1, a metering pump for supplying a fixed amount of a spinning solution main tank (not shown) filled with a spinning solution and a polymer spinning solution filled in the spinning solution main tank (Not shown) and discharge the polymer spinning solution in the spinning solution main tank, the nozzle block 111 is arranged in a plurality of nozzles 112 are arranged in a pin shape and the injection is located at the bottom of the nozzle 112 It is composed of a unit (110, 110 ') including a collector 113 spaced apart from the nozzle 112 and a voltage generator 114 for generating a high voltage to the collector 113 in order to integrate the polymer spinning solution. .

In the method of manufacturing nanofibers through the electrospinning apparatus 100, the spinning solution in the spinning solution main tank in which the spinning solution is filled is continuously metered into a plurality of nozzles 112 to which a high voltage is applied through a metering pump. The spinning solution supplied to the nozzle 112 is radiated and focused through the nozzle 112 on the collector 114 on which the high voltage is applied, so that a nanofiber web is formed, and the unit 110 of the electrospinning apparatus 100 is formed. The nanofiber web is fabricated on a long sheet 115 which is transferred to 110 ').

The nanofiber web manufactured by electrospinning is made of nonwoven fabrics, membranes and braids, and is widely used in agriculture, clothing, and industrial use, and is used for artificial leather, artificial suede, sanitary napkins, clothes, diapers, packaging materials, and sundries. It is used in various fields such as various filter materials, medical materials of gene carriers and defense materials such as bulletproof vests.

In addition, the nanofibers produced by electrospinning have a very large surface area compared to the volume and have fineness of several tens to hundreds of nanometers, and thus have advantages such as moisture permeability and waterproofing function. Products are being developed.

On the other hand, in recent years, a technique for applying an electric spinner to various fields has been proposed, but the size and weight of the individual device is considerable and at the same time composed of a plurality of unit form requires a separate space for installing and operating the device And electrospinning while the device is fixedly installed, it is applied to the life science field that carries drug delivery to the human body, hemostatic agent and wound dressing, and applied to skin membranes, blood vessels, and three-dimensional supports for bone / cartilage regeneration. There has been a problem that it is difficult to apply electrospinning to medical fields including tissue engineering and beauty fields such as skin cleansing, skin healing, skin therapy and skin masks.

In addition, the general electrospinning device has a problem that it is difficult to apply in various industrial sites that require a nanofiber web due to the difficulty in moving and handling. In other words, since the size and weight of the electrospinning device is considerable, it is difficult to move and handle it, and thus, it is difficult to apply the nanofiber web as a filter material by electrospinning directly to air conditioning-related facilities in various industrial sites.

Therefore, there is a demand for an electrospinning device that is easy to use and easy to move and handle in various fields such as life science, tissue engineering, medical, beauty and industrial fields.

The present invention has been made to solve the problems described above, and the life sciences to carry the drug delivery to the affected part of the patient, hemostatic agents and wound dressing and skin and bone regeneration and skin membranes, blood vessels, Applied in the medical field including the tissue engineering field applied to the three-dimensional support for bone / cartilage regeneration, and in the beauty field such as skin cleansing, skin healing, skin therapy, skin mask, and various industrial fields where filter materials are used. It is an object to provide this possible portable or portable electrospinning device.

In addition, the present invention, the polymer spinning solution is installed in the form of a cartridge replaceable, a commercial battery is applied as a power source for generating a high voltage to improve the convenience of use, the polymer spinning solution as a polymer, PAA (Poly Aspartic Acid) ), Biocompatible polymer materials including PLLA (Poly L-Lactic Acid), PGA (Poly Glycolic Acid), PLGA and the like, cellulose, collagen, collagen, gelatin, modified chitin, chitosan, DNA ( Natural macromolecular polymer materials including deoxyribonucleic acid, polyacrylonitrile (PAN), polyethylene oxide (PEO), polyethylene phthalate (PET), polyurethane (PU), High polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), polyacrylamide (PAA) and the like Now by the spinning liquid is applied at the same time moving and handling is easy easy for its object to provide a portable or handheld electrospinning devices that can be applied to various fields.

In order to achieve the above object, the present invention provides an electrospinning apparatus for electrospinning a polymer spinning solution, comprising: an electrospinning head for electrospinning a polymer spinning solution; And a control system for controlling the electrospinning head; It comprises a, it provides a mobile electrospinning device characterized in that the electrospinning of the polymer spinning solution to the affected part of the patient.

Here, the electrospinning head radiates the polymer spinning solution supplied to the nozzle block by a nozzle block to which the polymer spinning solution is supplied in the control system and at least one or more of the nozzle blocks, which are detachably coupled to each other. It consists of nozzles.

The control system includes a control unit that is controlably connected to the electrospinning head, a power supply unit electrically connected to the electrospinning head to supply power, and a supply pipe to the electrospinning head, wherein the polymer spinning solution filled therein It comprises a spinning solution supply for supplying an electrospinning head.

The control unit may further include a control panel including a keypad for operating the control system and the electrospinning head, and a display unit displaying an operation and an operation state of the control system and the electrospinning head.

At this time, an amplifier for amplifying the voltage supplied through the power supply to the electrospinning head is further provided.

In addition, the present invention is an electrospinning apparatus for electrospinning a polymer spinning solution, the case is formed of a portable pen type; A power supply unit comprising at least one commercial battery for supplying power; A spinning solution container in which the polymer spinning solution is filled and stored; A nozzle for electrospinning the polymer spinning solution filled and stored in the spinning solution container; It consists of a configuration including, and a control, it provides a portable electrospinning device characterized in that the electrospinning of the polymer spinning solution to the affected part of the user.

Here, the spinning solution container is made of a replaceable cartridge form, the spinning solution storage unit is filled and stored with a polymer spinning solution, and the piston for pressurizing the polymer spinning solution filled and stored in the spinning solution storage by an electrical signal It is configured to include a pressing portion in the form.

And the nozzle is formed in the form of a pin, the electrospinning the polymer spinning solution supplied from the spinning solution container, characterized in that it is provided in the center of the nozzle cap detachably coupled to the case.

In addition, an amplifier for amplifying the voltage supplied through the power supply unit for applying to the nozzle is further configured.

As described above, the present invention having the configuration as described above includes a biocompatible polymer material including a protein, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA), and PLGA. Natural macromolecular polymers including polycellulose, collagen, gelatin, gelatin, modified chitin, chitosan, deoxyribonucleic acid (DNA), polyacrylonitrile (PAN), polyethylene oxide PEO, polyethylene phthalate (PET), polyurethane (PU), polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), polyacrylamide By electrospinning polymer spinning solution containing PAA) etc., it is applied and applied to various fields such as life science, tissue engineering, medical and cosmetic fields. It can be used as an extracellular matrix (ECM) as well as anticipating drug activation by having a large surface area by electrospinning. Inflammation and secondary infection can be prevented, and it can be used for special purpose such as outdoor activities and military use, and polymer spinning solution filled and stored in a certain amount can be replaced with cartridge type and commercial battery It is easy to use and handle by being applied, and can be moved and handled after carrying, so that it can be applied and used in various industrial sites when electrospinning polymer spinning solution used as a conventional filter material. It can be used for ease of use and handling.

1 is a view schematically showing an electrospinning device according to the prior art,

2 is a perspective view schematically showing a mobile electrospinning device according to the present invention;

3 is a perspective view schematically showing an electrospinning head of a mobile electrospinning apparatus according to the present invention;

Figure 4 is a side view schematically showing the electrospinning head of the mobile electrospinning apparatus according to the present invention,

5 is a view schematically showing an embodiment of a mobile electrospinning apparatus according to the present invention,

6 is a perspective view schematically showing a portable electrospinning device according to the present invention;

7 is a partial cross-sectional view schematically showing a portable electrospinning device according to the present invention;

8 is a view schematically showing an embodiment of a portable electrospinning apparatus according to the present invention.

1: mobile electrospinning apparatus, 10: control system,

11: control panel, 11a: keypad,

11b: display unit, 12: power supply,

13: mounting portion, 15: spinning solution supply device,

15a, 15b: storage tank, 30: electrospinning head,

31: nozzle block, 33: nozzle,

35: on / off switch,

2: portable electrospinning apparatus, 20: case,

22: control switch, 40: power supply,

50: spinning solution container, 51: spinning solution filling unit,

53: pressurization portion, 70: nozzle,

71: nozzle cap.

Hereinafter, a preferred embodiment of a mobile or portable electrospinning apparatus according to the present invention will be described in detail with reference to the accompanying drawings. In addition, the present embodiment is not intended to limit the scope of the present invention, but is presented by way of example only, and various modifications may be made without departing from the technical gist of the present invention.

[1] mobile electrospinning apparatus <FIGS. 2-5

Figure 2 is a perspective view schematically showing a mobile electrospinning device according to the present invention, Figure 3 is a perspective view schematically showing an electrospinning head of a mobile electrospinning apparatus according to the present invention, Figure 4 is a mobile electrospinning according to the present invention FIG. 5 is a side view schematically showing an electrospinning head of the apparatus, and FIG. 5 is a diagram schematically showing an embodiment of a mobile electrospinning apparatus according to the present invention.

6 is a perspective view schematically showing a portable electrospinning device according to the present invention, FIG. 7 is a partial cross-sectional view schematically showing a portable electrospinning device according to the present invention, and FIG. 8 is a portable electrospinning device according to the present invention. A diagram schematically showing an embodiment of the.

As shown in the figure, the mobile electrospinning apparatus 1 according to the present invention comprises a control system 10 and an electrospinning head 30.

The control system 10 is configured to include a control unit (not shown), a power supply (Power Supply) 12, the holder 13 and the spinning solution supply device (15).

The controller is controlably connected to the control system 10 and the electrospinning head 30, and controls the operation and operation of the control system 10 and the electrospinning head 30.

To this end, the control unit includes a keypad 11a for operating the control system 10 and the electrospinning head 30, and a display unit 11b for displaying the operation and operation states of the control system 10 and the electrospinning head 30. FIG. It is configured to include a control panel 11 is provided with.

The power supply 12 is for supplying power supplied from the outside to the electrospinning head 30, and generates a voltage to the nozzle 33 of the electrospinning head 30 to be described later.

The mounting portion 13 is for mounting and mounting the electrospinning head 30 and is formed to correspond to the shape of the electrospinning head 30.

The spinning solution supply device 15 is for supplying a polymer spinning solution to the electrospinning head 30, the protein, Poly Aspartic Acid (PAA), Poly L-Lactic Acid (PLLA), Poly Glycolic Acid (PLA), PLGA Natural macromolecules filled with polymer spinning solution containing biocompatible polymer materials such as (biodegradable polymers) or cellulose (Cellulose), collagen (Collagen), gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid) The polymer spinning solution containing the polymer material is filled and stored.

In one embodiment of the present invention, the spinning solution supply device 15, such as protein, Poly Aspartic Acid (PAA), Poly L-Lactic Acid (PLLA), Poly Glycolic Acid (PGA), PLGA (biodegradable polymer), etc. Polymer spinning solution containing biocompatible polymer material or polymer room containing natural macromolecular polymer material such as cellulose, collagen, gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid) Although the use solution is filled and stored, it can be variously modified to suit the application field to which the polymer spinning solution is applied.

As described above, the spinning solution supply device 15 in which the polymer spinning solution is filled and stored therein supplies the stored polymer spinning solution to the electrospinning head 30.

To this end, the control system 10 is provided with a pump (not shown) for supplying the polymer spinning solution filled and stored in the spinning solution supply device 15 to the electrospinning head 30.

Here, the spinning solution supply device 15 is preferably provided with one or more storage tanks (15a, 15b) for storing one or more polymer spinning solution, the number of the storage tank (15a, 15b) is not limited thereto. No.

On the other hand, the control system 10 is preferably further provided with a metering pump (not shown) for quantitatively supplying the polymer spinning solution filled and stored in the spinning solution supply device 15 to the electrospinning head 30, Preferably, a sensor (not shown) is further provided to detect various states of the control system 10 and the electrospinning head 30, but is not limited thereto.

The electrospinning head 30 is connected to the control system 10 by a connecting member (not shown) such as a cable or a tube of a flexible material, and comprises a nozzle block 31 and a nozzle 33. do.

The nozzle block 31 is filled and stored in the spinning solution supply device 15, Poly Aspartic Acid (PAA), Poly L-Lactic Acid (PLLA), Poly Glycolic Acid (PGA), PLGA (Biodegradable Polymer) Polymer spinning solution containing biocompatible polymer materials such as polymers or polymers containing natural macromolecular polymer materials such as cellulose, collagen, gelatin, modified chitin, chitosan and DNA (Deoxyribonucleic Acid) At least one polymer spinning solution is used.

Here, the nozzle block 31 is connected to the spinning solution supply device 15 and a supply pipe (not shown) to supply the polymer spinning solution filled and stored in the spinning solution supply device 15 to the nozzle block 31. The supply pipe is provided in a connecting member such as a cable or a tube of a flexible material.

The nozzle 33 is formed in a pin shape, the protein supplied to the nozzle block 31, PAA (Poly Aspartic Acid), PLLA (Poly L-Lactic Acid), PGA (Poly Glycolic Acid), PLGA (biodegradable polymer) Polymer spinning solution containing biocompatible polymer materials such as) or polymers containing natural macromolecular polymer materials such as cellulose, collagen, gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid) Any one or more polymer spinning solution of the spinning solution for electrospinning the affected part of the patient, is detachably coupled to the nozzle block 31, is arranged in a plurality of at least one.

As described above, when the nozzle 33 is detachably coupled to the nozzle block 31, the nozzle 33 may be replaced with a new nozzle 33 after separating only the specific nozzle 33 in case of abnormality or failure.

In one embodiment of the present invention, at least one or more nozzles 33 are detachably coupled to the nozzle block 31, but the nozzle body is provided with a plurality of nozzles 33 in the longitudinal direction in the nozzle block 31. (Not shown) may be provided, or a plurality of nozzle bodies provided with a plurality of nozzles 33 may be provided in the form of a nozzle block, but is not limited thereto.

In addition, in one embodiment of the present invention, a plurality of the nozzle 33 is regularly arranged in the nozzle block 31, it is also possible that the plurality of the nozzle 33 is irregularly arranged in the nozzle block 31, The nozzle 33 may be arranged only at a predetermined position of the nozzle block 31, the nozzle 33 may be arranged in a plurality of groups at a predetermined position of the nozzle block 31, and the nozzle ( The number, position, and arrangement of 33) are not limited thereto, and various modifications can be made.

On the other hand, the nozzle 33 is electrically connected to the power supply device 12 of the control system 10, the voltage supplied from the power supply device is generated on the affected part of the patient through the nozzle 33, the voltage is The polymer spinning solution is electrospun on the affected area of the patient.

To this end, the nozzle 33 is electrically connected to the power supply device 12 by a cable (not shown) to supply voltage from the power supply device 12 to the nozzle 33. The cable for electrically connecting the nozzle 33 is preferably provided in the connecting member, but is not limited thereto.

The electrospinning head 30 is provided with an amplifier (not shown) for amplifying the voltage supplied from the power supply device 12 of the control system 10 to the nozzle 33 to a high voltage.

By the structure as described above, after the voltage supplied from the power supply device 12 is amplified to a high voltage through an amplifier, a high voltage is generated on the affected part of the patient through the nozzle 33, and the electric power through the nozzle 33 The spinning polymer spinning solution is accumulated in the affected area, face or skin of the patient.

On the other hand, the electrospinning head 30 is provided with an on / off switch 35 to control the operation and operation of the electrospinning head 30, but is provided in the control unit of the control system 10 It is also possible to control the operation and operation of the electrospinning head 30 via the keypad (11a).

In one embodiment of the present invention, the electrospinning head 30 is located in the affected part of the patient and then the protein in the affected part, Poly Aspartic Acid (PAA), Poly L-Lactic Acid (PLLA), Poly Glycolic Acid (PGA), Biocompatible polymer materials including PLGA (biodegradable polymer) and natural macromolecular polymer materials including cellulose, collagen, gelatin, modified chitin, chitosan, deoxyribonucleic acid, etc. Although it is illustrated that the polymer spinning solution of the electrospinning is applied to the medical field, the polymer spinning solution to be filled and stored in the spinning solution supply device 15 is different, the electrospinning head 30 of the patient's face and Electrospinning the skin or the like is also preferably applied to a cosmetic field such as skin cleansing, skin healing, skin therapy, and skin mask, but is not limited thereto.

In addition, a polyacrylonitrile (PAN), polyethylene oxide (PEO), polyethylene terephthalate (PET) to the spinning solution supply device 15 of the mobile electrospinning apparatus 1 according to the present invention. Filling and storage of polymer spinning solution, including polyurethane (PU), polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), polyacrylamide (PAA), etc. After that, it is also possible to use the filter material by electrospinning the nanofiber web to the required place and location of various industrial sites.

For example, the mobile electrospinning apparatus 1 according to the present invention is carried by a field worker and moved to a ventilating hole installed in a subway or various construction sites, and then directly by electrospinning a nanofiber web to a venting hole to be used as a filter material. It can be applied to various industrial sites where electrospinning is required, such as improving filter efficiency.

As described above, when the mobile electrospinning apparatus 1 according to the present invention is applied to various industrial sites, the polymer spinning solution filled and stored in the spinning solution supply device 15 is polyacrylonitrile (PAN), Polyethylene oxide (PEO), polyethylene terephthalate (PET), polyurethane (PU), polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), biodegradation When composed of at least one selected from the group consisting of a polymer (PLGA), PGA, poly acrylamide (PAA), cellulose (Cellulose), gelatin, chitosan, as the solute of the polymer spinning solution, the siloxane group alone or siloxane Groups and monomethacrylates, vinyl, hydrides, distearates, bis (1,2-hydroxy), methoxy, ethoxylates, propoxylates Polymers containing a bonding group selected from diglycidyl ether, monoglycidyl ether, monohydroxyalkyl, bishydroxyalkyl, chlorine and bis ((aminoethyl-aminopropyl) dimethoxysilyl) ether can be used. , Polyvinylidene fluoride, polyvinylidene fluoride-hexafluoropropylene copolymer, or a composite composition thereof, polyamide, polyimide, polyamideimide, poly (meth-phenylene isophthalamide), metaaramid, Any one or more materials selected from the group consisting of polyethylenechlorotrifluoroethylene, polychlorotrifluoroethylene, polymethylmethacrylate, polyacrylonitrile, polyvinylidenechloride-acrylonitrile copolymer, polyacrylamide, and the like It is preferable that it consists of, and a solvent is phenol, formic acid, a sulfuric acid, m-cresol, Fluoroacet & hydride / dichloromethane, water, N-methylmorpholine N-oxide, chloroform, tetrahydrofuran and aliphatic ketone group, as methyl isobutyl ketone, methyl ethyl ketone, aliphatic hydroxyl group, m -Butyl alcohol, isobutyl alcohol, isopropyl alcohol, methyl alcohol, ethanol, aliphatic compound group, hexane, tetrachloroethylene, acetone, glycol group, propylene glycol, diethylene glycol, ethylene glycol, halogen compound group, triclo As ethylene, dichloromethane, aromatic compound group, toluene, xylene, aliphatic ring compound group, cyclohexanone, cyclohexane and ester group, n-butyl acetate, ethyl acetate, aliphatic ether group, butyl cell As losalb, acetic acid 2-ethoxyethanol, 2-ethoxyethanol, amide group. One or more substances selected from dimethylformamide, dimethylacetamide, and the like are preferable, but are not limited thereto.

As described above, the handle (not shown) or the shoulder on the control system 10 and the electrospinning head 30 to facilitate carrying and moving when the mobile electrospinning apparatus 1 according to the present invention is applied to various industrial sites. Preferably, the mounting portion is provided separately, and it is preferable that the field worker is configured to easily carry and move the mobile electrospinning apparatus 1 at a work site or an industrial site after gripping and mounting a handle or shoulder mount. However, it is not limited thereto.

Hereinafter, the operation of the mobile electrospinning apparatus according to the present invention will be described with reference to FIG.

First, the mobile electrospinning apparatus 1 is placed in the affected part of the patient and then operated. That is, the mobile electrospinning apparatus 1 is positioned on the affected part of the patient and then operated and controlled by the control unit or the on / off switch 35 of the control system 10 to operate and operate the electrospinning head 30.

As described above, the electrospinning head 30 of the mobile electrospinning apparatus 1 according to the present invention is positioned on the affected part of the patient, and then the keypad 11a provided in the control panel 11 of the control unit is operated, or The on / off switch 35 of the spinning head 30 is operated and controlled to electrospin the polymer spinning solution to the affected part of the patient.

At this time, the polymer spinning solution is supplied from the spinning solution supply device 15 of the control system 10 to the electrospinning head 30, and is filled in each of the

storage tanks

15a and 15b of the spinning solution supply device 15. And biocompatible polymer materials, including cellulose, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA), biodegradable polymer (PLGA), and the like. Polymer spinning solution such as natural macromolecular polymer material including collagen, gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid) and the like is supplied to the electrospinning head 30.

Here, the polymer spinning solution supplied from the spinning solution supply device 15 of the control system 10 to the electrospinning head 30 is supplied to the nozzle block 31 of the electrospinning head 30, the nozzle block The polymer spinning solution supplied to 31 is sprayed through the nozzle 33 and electrospun.

As described above, power is supplied from the power supply device 12 to the nozzle 33 during the electrospinning of the polymer spinning solution in the electrospinning head 30 to perform electrospinning on the affected part of the patient.

At this time, the body of the patient in the nozzle 33 of the electrospinning head 30 by performing the role of a collector is provided in the general electrospinning device when the power is applied from the power supply device 12 to the nozzle 33 The polymer spinning solution is electrospun.

That is, the positive electrode or the negative electrode of the power supply device 12 of the mobile electrospinning apparatus 1 is connected to the nozzle 33, and the affected part of the patient becomes the negative electrode or the positive electrode, whereby the polymer spinning solution is electrospun on the affected part of the patient and focused. do.

As described above, the mobile electrospinning apparatus 1 according to the present invention includes a protein, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA), and biodegradable polymer (PLGA). Electrospinning of a polymer compatible solution such as a biocompatible polymer material containing a natural or biological macromolecule material including cellulose (Cellulose), collagen (Collagen), gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid), etc. This can prevent secondary infections through pain and lesions.

Here, the electrospinning amount of the polymer spinning solution electrospun to the affected part of the patient is preferably made to be controlled by the control unit of the control system 10, it is supplied to the electrospinning head 30 from the spinning solution supply device 15 Preferably, the amount of the polymer spinning solution to be controlled is also controlled by the control unit.

In addition, a storage unit, a timer, and the like are built in the control system 10 so that the state, treatment details, electrospinning amount, etc. of the patients are stored or made to perform electrospinning on the affected part of the patient for a specific time through a timer. Preferred but not limited thereto.

Meanwhile, in the present invention, the mobile electrospinning apparatus 1 shows an embodiment of electrospinning to the affected part of the patient, but the tissue for long-term regeneration by applying a natural or synthetic biomaterial to the mobile electrospinning apparatus 1 It is also preferable to produce supports such as supports by electrospinning.

At this time, by adjusting the properties of the support as required, or by sustaining cell viability, the ratio of volume to area is very high, the porosity is appropriate, the desired size, texture and shape can be appropriately tailored, necessary properties and possible The composition and preparation of the support can be adjusted to conform to.

In addition, the structure and shape of the support after the manufacture can be applied to tissue engineering scaffolds, such as to mimic the cellular environment at the wound site and affected part corresponding to the biological tissue.

In addition, by the electrospinning of the mobile electrospinning apparatus (1) according to the present invention to perform the role of a gene transfer medium, such as delivery of bioactive molecules such as drugs, proteins and DNA, or to reduce inflammation, infection To prevent the adhesion and adhesion due to contamination and infection, the medicinal material may be mixed with the polymer spinning solution and then electrospun to the affected area to act as an anti-adhesion barrier.

As described above, the three-dimensional for the skin science, blood vessels, bone / cartilage regeneration and the field of life sciences to carry the carrier, hemostatic agent and wound dressing to deliver the drug to the human body through the mobile electrospinning apparatus 1 according to the present invention By applying electrospinning to the medical field including the field of tissue engineering applied to the scaffold, the electrospinning apparatus for producing nanofiber webs by electrospinning has a wide range of various fields. Applicable at

Here, the mobile electrospinning apparatus 1 according to the present invention may be installed in a home, not a medical institution such as a hospital or a clinic, and may be utilized in personal medical fields, such as the purpose of treating a patient who has difficulty in moving. It is also preferable to treat (1) the affected part of the patient by operating and controlling the patient, the caregiver or the family.

On the other hand, in one embodiment of the present invention is limited to using the mobile electrospinning device (1), but is also preferably used in the field of beauty, such as skin cleansing, skin healing, skin therapy, skin mask, It is not limited.

In addition, polyacrylonitrile (PAN), polyethylene oxide (PEO), polyethylene terephthalate (PET), polyurethane (PU), and polyvinyl chloride are supplied to the spinning solution supply device 15. After the filling and storage of polymer spinning solution used as a general filter material, including polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), poly acrylamide (PAA), etc. In the field or construction site, while the mobile worker carries the mobile electrospinning device (1) and moves it, the nanofiber web is directly electrospun to the place and location where electrospinning is required to be used as a filter material and to improve the filter efficiency. It is also preferable to apply and utilize the mobile electrospinning apparatus 1 according to the present invention in various industrial sites.

[2] portable electrospinning apparatus <Figs. 5 to 8>

Figure 2 is a perspective view schematically showing a portable electrospinning device according to the present invention, Figure 7 is a partial cross-sectional view schematically showing a portable electrospinning device according to the present invention, Figure 8 is one of the portable electrospinning device according to the present invention The figure schematically shows an embodiment.

As shown in the drawings, the portable electrospinning apparatus 2 according to the present invention includes a case 20, a power supply unit 40, a spinning solution container 50, a nozzle 70, and a control unit (not shown). Consists of the configuration.

The case 20 is formed in a cylindrical shape of a portable pen type (Pen Type). In one embodiment of the present invention, the case 20 is formed in a cylindrical shape, but may be formed in a cylindrical shape of a polygonal shape.

The power supply unit 40 is formed in the portable electrospinning apparatus 2, and a commercial battery (not shown) is installed to apply a voltage to the nozzle 70, and is electrically connected to the nozzle 70. One or more commercial batteries are inserted. To this end, a cover (not shown) is provided on the upper side of the case 20 of the portable electrospinning apparatus 2 (not shown), and the cover is opened and closed.

Here, an amplifier (not shown) is further provided to amplify the voltage supplied when the voltage is supplied from the power supply unit 40 to the nozzle 70. As described above, a voltage amplifier is provided in the portable electrospinning apparatus 2 to apply a high voltage from the commercial battery to the nozzle 70.

The spinning solution container 50 is located under the power supply 40 in the case 20, the polymer spinning solution is filled and stored therein, and is installed replaceable in the form of a cartridge.

Here, the spinning solution container 50 is composed of a configuration including a spinning solution filling unit 51 and the pressing unit (53). That is, the spinning solution container 50 is pressurized through the nozzle 70 while pressurizing the spinning solution filling part 51 filled with the polymer spinning solution and the polymer spinning solution filled and stored in the spinning solution filling part 51. It is configured to include a pressing portion 53 for spinning.

At this time, the pressurizing portion 53 is preferably formed in the form of a piston, if the electrospinning can be performed through the nozzle 70 while pressing the polymer spinning solution filled and stored in the spinning solution filling unit 51, other It is also possible to have a variety of forms.

Pressurization of the pressurizing portion 53 provided in the spinning solution container 50 of the portable electrospinning apparatus 2 according to the present invention to pressurize the polymer spinning solution is preferably made of a general configuration operated by an electrical signal, A separate pressure switch is provided, and the user can hold the portable electrospinning apparatus 2 and pressurize the polymer spinning solution while applying a force to the pressure switch to electrospin.

Herein, the spinning solution container 50 may vary the amount of the polymer spinning solution filled and stored in the spinning solution filling part 51 therein, or may be limited to a single use, or a type of polymer spinning solution filled and stored. Various changes can be made, such as changing the color accordingly.

In addition, a display unit (not shown) is separately provided on the outer surface of the case 20 of the portable electrospinning apparatus 2 so as to provide a kind, an amount of use, a residual amount, or the like of the spinning solution container 50 installed in the portable electrospinning apparatus 2. It is also possible to inform the user of the replacement time.

Herein, the spinning solution filling part 51 of the spinning solution container 50 includes a protein, poly aspartic acid (PAA), poly l-lactic acid (PLLA), polyglycolic acid (PGA), and biodegradable polymer (PLGA). It is filled with a biocompatible polymer material and a polymer antiseptic solution such as cellulose (Cellulose), collagen (Collagen), gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid), etc. But is not limited thereto.

The nozzle 70 is formed in a pin shape, and electrospins the polymer spinning solution filled and stored in the spinning solution container 50.

Proteins filled and stored in the spinning solution filling unit 51 of the spinning solution container 50 according to the structure as described above, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA) , Biocompatible polymer materials including PLGA (biodegradable polymer) and natural macromolecular polymer materials including cellulose, collagen, gelatin, modified chitin, chitosan, deoxyribonucleic acid, DNA, etc. A polymer spinning solution such as the like is electrospun through the nozzle 70.

The nozzle 70 is connected to the spinning solution container 50 and is provided at the center of the nozzle cap 71 that is detachably coupled to the end of the case 20 of the portable electrospinning apparatus 2.

By the above structure, it is easy to replace and replace the nozzle 70, such as replacing and replacing the nozzle cap 71 in the case 20 in case of failure or abnormality of the nozzle 70.

Here, the spinning solution to be inserted into the portable electrospinning device (2) after removing the nozzle cap 71 from the case 20 of the portable electrospinning device (2) during the exchange and replacement of the spinning solution container (50) The container 50 is replaced with a new one, and after replacing and replacing the spinning solution container 50, the nozzle cap 71 is coupled to the case 20 of the portable electrospinning apparatus 2 again.

In one embodiment of the present invention, but after removing the nozzle cap 71 from the portable electrospinning device (2) to replace and replace the spinning solution container 50 is installed therein, the spinning solution container ( 50 and the nozzle cap 71 are integrally formed so that both the spinning solution container 50 and the nozzle cap 71 are new when the spinning solution container 50 is replaced or replaced in the portable electrospinning apparatus 2. It is also possible to be replaced and replaced with.

Meanwhile, in one embodiment of the present invention, the portable electrospinning apparatus 2 is provided with one nozzle 70 to be electrospun, but the number of the nozzles 70 is not limited thereto.

The control unit is provided in the portable electrospinning apparatus (2), it is made to control the amount of polymer spinning solution supplied to the nozzle 70 through the spinning solution container 50, the power supply unit 40 and power on / off, etc. .

On the other hand, the control switch 22 is provided to expose a predetermined portion outside the case 20 of the portable electrospinning device 2, the control switch 22 from the spinning solution container 50 to the nozzle 70 It is made to control the amount of polymer spinning solution supplied.

In one embodiment of the present invention, although the control switch 22 provided on the outside of the case 20 of the portable electrospinning device 2 is in the form of a dial, the control switch 22 is a digital form of a touch panel or It is also possible to form a keypad.

In addition, the control switch 22 may be configured to include a power on / off switch of the portable electrospinning apparatus 2 to control the operation and operation of the portable electrical apparatus, but is not limited thereto.

In one embodiment of the present invention, the portable electrospinning apparatus (2) is located in the affected part of the patient and then the protein in the affected part, Poly Aspartic Acid (PAA), Poly L-Lactic Acid (PLLA), Poly Glycolic Acid (PGA), Biocompatible polymer materials including PLGA (biodegradable polymer) and natural macromolecular polymer materials including cellulose, collagen, gelatin, modified chitin, chitosan, deoxyribonucleic acid, etc. Although it is illustrated that the polymer spinning solution of the electrospinning applied to the medical field, the polymer spinning solution filled and stored in the spinning solution container 50 is different, the nozzle 70 of the portable electrospinning device (2) The electrospinning of the patient's face and skin, etc., is also preferably applied to beauty fields such as skin cleansing, skin healing, skin therapy, and skin mask, but is not limited thereto.

In addition, in the spinning solution container 50 of the portable electrospinning apparatus 2 according to the present invention, polyacrylonitrile (PAN), polyethylene oxide (PEO), polyethylene terephthalate (PET), Filled and stored polymer spinning solution containing polyurethane (PU), polyvinylidene fluoride (PVDF), polyvinylpyrrolidone (PVP), polyacrylamide (PAA), etc. It is also possible to use it as a filter material by electrospinning the nanofiber web at the required place and location of various industrial sites while carrying it by the worker at all times.

Hereinafter, the operation of the portable electrospinning apparatus according to the present invention will be described with reference to FIG.

First, the portable electrospinning apparatus 2 is placed on the affected part of the user and then operated. That is, when a user is wounded or injured in a general situation such as an outdoor activity or a special situation such as an army, the portable electrospinning apparatus 2 is placed on the affected part of the user, and then a power on / off switch (not shown), etc. To operate and operate the portable electrospinning apparatus 2.

As described above, the portable electrospinning apparatus 2 according to the present invention is placed on the affected part of the patient, and then the polymer spinning solution is electrospun on the affected part of the user through the nozzle 70.

At this time, the spinning solution is supplied from the spinning solution container 50 of the portable electrospinning apparatus 2 to the nozzle 70, the protein filled and stored in the spinning solution filling unit 51 of the spinning solution container 50, Biocompatible polymers or materials such as PAA (Poly Aspartic Acid), PLLA (Poly L-Lactic Acid), PGA (Poly Glycolic Acid), PLGA (Biodegradable Polymer), or Cellulose, Collagen, Gelatin, Polymer spinning solution such as natural macromolecular polymer material including modified chitin, chitosan, deoxyribonucleic acid (DNA) and the like is supplied to the nozzle 70.

As described above, the amount of the polymer spinning solution electrospun through the nozzle 70 while operating the control switch 22 which is controlably connected to the control unit after placing the portable electrospinning device 2 in the affected part of the user While adjusting, electrospin the polymer spinning solution on the affected part.

At this time, power is supplied from the power supply unit 40 to the nozzle 70 to perform electrospinning on the affected part of the user. That is, the power supply 40 is supplied to the nozzle 70, the high voltage amplified by the voltage amplifier is applied to the nozzle 70, the user's body serves as a collector provided in the general electrospinning apparatus (2) By doing so, the polymer spinning solution is electrospun from the nozzle 70 to the affected part of the user.

That is, the positive electrode or the negative electrode of the power supply unit 40 of the portable electrospinning apparatus is connected to the nozzle 70, and the user's body becomes the negative electrode or the positive electrode, and the polymer spinning solution is electrospun onto the user's body to focus.

As described above, the portable electrospinning apparatus 2 according to the present invention includes a protein, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA), biodegradable polymer (PLGA), and the like on the affected part of the user. Biocompatible polymer materials or biocompatible polymer materials including cellulose (Cellulose), collagen (Collagen), gelatin, modified chitin, chitosan (Citosan), PGA (Poly Glycolic Acid), PLGA (biodegradable polymer), or the like A polymer spinning solution such as natural macromolecular polymer material including cellulose, collagen, gelatin, modified chitin, chitosan, DNA (Deoxyribonucleic Acid) and the like is supplied to the nozzle 70.

As described above, the portable electrospinning apparatus 2 according to the present invention includes a protein, poly aspartic acid (PAA), poly l-lactic acid (PLLA), poly glycol acid (PGA), biodegradable polymer (PLGA), and the like on the affected part of the user. Biocompatible polymer materials or cellulose (Cellulose), collagen (Collagen), gelatin, modified chitin, chitosan (Chitosan), PVDF, polyvinylpyrrolidone (PVP), polyacrylamide (PAA) After filling and storing the polymer spinning solution used as a general filter material, such as in the industrial site or construction site, the site workers carry the portable electrospinning device (2) at all times and then move and move and require the electrospinning and Applying and utilizing the portable electrospinning apparatus (2) according to the present invention to various industrial sites, such as directly using a nanofiber web at a location and using it as a filter material to improve filter efficiency. It is preferred.

While the invention has been shown and described in connection with particular embodiments, it will be appreciated that various modifications and changes can be made without departing from the spirit and scope of the invention as set forth in the appended claims. Anyone who owns it can easily find out.

Claims

In the electrospinning apparatus for electrospinning the polymer spinning solution,

An electrospinning head for electrospinning a polymer spinning solution; And

A control system for controlling the electrospinning head;

A mobile electrospinning device comprising a, wherein the electrospinning of the polymer spinning solution to the affected part of the patient.
The method according to claim 1,

The electrospinning head radiates the polymer spinning solution supplied to the nozzle block by a nozzle block in which a polymer spinning solution is supplied in a control system and at least one or more of the plurality of nozzle blocks arranged in the nozzle block. Mobile electrospinning apparatus characterized in that it comprises a nozzle.
The method according to claim 1,

The control system includes a control unit that is controllably connected to the electrospinning head, a power supply device electrically connected to the electrospinning head to supply power, and a supply pipe to the electrospinning head, the polymer spinning solution filled therein. And a radiation solution supply device for supplying the electrospinning head, and an amplifier for amplifying the voltage supplied through the power supply device and applying the electrospinning head to the electrospinning head.
The method according to claim 3,

The control unit further comprises a control panel comprising a control panel including a keypad for operating the control system and the electrospinning head and a display unit for displaying the operation and operation state of the control system and the electrospinning head. Device.
The method according to claim 3,

And an amplifier for amplifying the voltage supplied through the power supply device and applying it to the electrospinning head.
In the electrospinning apparatus for electrospinning the polymer spinning solution,

A case formed of a portable pen type;

A power supply unit comprising at least one commercial battery for supplying power;

A spinning solution container in which the polymer spinning solution is filled and stored;

A nozzle for electrospinning the polymer spinning solution filled and stored in the spinning solution container; And

Control unit;

It is made of a configuration comprising a, portable electrospinning apparatus characterized in that the electrospinning the polymer spinning solution to the affected part of the user.
The method according to claim 6,

The spinning solution container is made of a replaceable cartridge type, the spinning solution storage unit is filled and stored with a polymer spinning solution, and the piston type to pressurize the polymer spinning solution filled and stored in the spinning solution storage by an electrical signal Portable electrospinning apparatus comprising a pressurizing unit.
The method according to claim 6,

The nozzle is formed in the form of a pin, the electrospinning of the polymer spinning solution supplied from the spinning solution container, characterized in that the portable electrospinning device is provided in the center of the nozzle cap detachably coupled to the case.
The method according to claim 6,

Portable electrospinning apparatus characterized in that the amplifier for amplifying the voltage supplied through the power supply unit for applying to the nozzle.