WO2016005564A3 - Anticorps dirigés contre le facteur v activé - Google Patents
Anticorps dirigés contre le facteur v activé Download PDFInfo
- Publication number
- WO2016005564A3 WO2016005564A3 PCT/EP2015/065848 EP2015065848W WO2016005564A3 WO 2016005564 A3 WO2016005564 A3 WO 2016005564A3 EP 2015065848 W EP2015065848 W EP 2015065848W WO 2016005564 A3 WO2016005564 A3 WO 2016005564A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- activated factor
- antibodies against
- against activated
- factor
- fva
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des anticorps monoclonaux ou des fragments de ceux-ci, qui se lient au Facteur V activé (FVa), qu présentent un effet pro-coagulant, ainsi que leurs utilisations thérapeutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14176717 | 2014-07-11 | ||
EP14176717.8 | 2014-07-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016005564A2 WO2016005564A2 (fr) | 2016-01-14 |
WO2016005564A3 true WO2016005564A3 (fr) | 2016-04-07 |
Family
ID=51162604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2015/065848 WO2016005564A2 (fr) | 2014-07-11 | 2015-07-10 | Anticorps dirigés contre le facteur v activé |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR101185A1 (fr) |
TW (1) | TW201617371A (fr) |
WO (1) | WO2016005564A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019071116A1 (fr) * | 2017-10-05 | 2019-04-11 | Epivax, Inc. | Épitopes de lymphocytes t régulateurs |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5910576A (en) * | 1994-02-14 | 1999-06-08 | Rijks Universiteit Leiden | Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein |
WO2005111075A2 (fr) * | 2004-05-18 | 2005-11-24 | University Of Vermont And State Agricultural College | Structure cristalline de facteur vai et procede d'identification de modulateurs de facteurs sanguins va |
WO2007101106A2 (fr) * | 2006-02-23 | 2007-09-07 | The Children's Hospital Of Philadelphia | Compositions et méthodes pour moduler une hémostase au moyen de différentes formes de facteur v activé |
WO2008067056A2 (fr) * | 2006-10-16 | 2008-06-05 | Novelmed Therapeutics, Inc. | Procédé d'inhibition de la coagulation avec des anticorps anti-facteur va humains et utilisation de ceux-ci |
-
2015
- 2015-07-10 AR ARP150102212A patent/AR101185A1/es unknown
- 2015-07-10 WO PCT/EP2015/065848 patent/WO2016005564A2/fr active Application Filing
- 2015-07-13 TW TW104122521A patent/TW201617371A/zh unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5910576A (en) * | 1994-02-14 | 1999-06-08 | Rijks Universiteit Leiden | Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein |
WO2005111075A2 (fr) * | 2004-05-18 | 2005-11-24 | University Of Vermont And State Agricultural College | Structure cristalline de facteur vai et procede d'identification de modulateurs de facteurs sanguins va |
WO2007101106A2 (fr) * | 2006-02-23 | 2007-09-07 | The Children's Hospital Of Philadelphia | Compositions et méthodes pour moduler une hémostase au moyen de différentes formes de facteur v activé |
WO2008067056A2 (fr) * | 2006-10-16 | 2008-06-05 | Novelmed Therapeutics, Inc. | Procédé d'inhibition de la coagulation avec des anticorps anti-facteur va humains et utilisation de ceux-ci |
Non-Patent Citations (6)
Title |
---|
ANNETTE VON DRYGALSKI ET AL: "Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice", vol. 120, no. 21, 1 November 2012 (2012-11-01), XP002722413, ISSN: 0006-4971, Retrieved from the Internet <URL:https://ash.confex.com/ash/2012/webprogram/Paper50002.html> [retrieved on 20150917] * |
KALAFATIS M ET AL: "Contribution of the heavy and light chains of factor Va to the interaction with factor Xa", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 21, 31 May 1994 (1994-05-31), pages 6538 - 6545, XP002590638, ISSN: 0006-2960 * |
KENNETH SEGERS ET AL: "Coagulation factor V and thrombophilia: Background and mechanisms", THROMBOSIS AND HAEMOSTASIS, vol. 98, no. 3, 17 October 2007 (2007-10-17), pages 530 - 42, XP055175994, ISSN: 0340-6245, DOI: 10.1160/TH07-02-0150 * |
SCHLACHTERMAN A ET AL: "Factor V Leiden improves in vivo hemostasis in murine hemophilia models", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 3, no. 12, 1 December 2005 (2005-12-01), pages 2730 - 2737, XP008130621, ISSN: 1538-7933, DOI: 10.1111/J.1538-7836.2005.01639.X * |
SUHNG WOOK KIM ET AL: "Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis +", BIOCHEMISTRY, vol. 39, no. 8, 1 February 2000 (2000-02-01), pages 1951 - 1958, XP055171137, ISSN: 0006-2960, DOI: 10.1021/bi992256r * |
W B FOSTER ET AL: "Monoclonal Antibodies Selective for Activated Factor V", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 9, 10 March 1983 (1983-03-10), pages 5606 - 5613, XP055177012, Retrieved from the Internet <URL:http://www.jbc.org/content/258/9/5608.full.pdf> [retrieved on 20150316] * |
Also Published As
Publication number | Publication date |
---|---|
WO2016005564A2 (fr) | 2016-01-14 |
TW201617371A (zh) | 2016-05-16 |
AR101185A1 (es) | 2016-11-30 |
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