WO2015186691A1 - Système d'endoscope, dispositif de mesure optique, et procédé de calcul de valeur caractéristique - Google Patents

Système d'endoscope, dispositif de mesure optique, et procédé de calcul de valeur caractéristique Download PDF

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Publication number
WO2015186691A1
WO2015186691A1 PCT/JP2015/065867 JP2015065867W WO2015186691A1 WO 2015186691 A1 WO2015186691 A1 WO 2015186691A1 JP 2015065867 W JP2015065867 W JP 2015065867W WO 2015186691 A1 WO2015186691 A1 WO 2015186691A1
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Prior art keywords
light
measurement
unit
endoscope
light source
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PCT/JP2015/065867
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English (en)
Japanese (ja)
Inventor
誠悟 伊藤
至峰 小林
鳥山　誠記
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オリンパス株式会社
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Publication of WO2015186691A1 publication Critical patent/WO2015186691A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor

Definitions

  • the present invention relates to an endoscope system, an optical measurement apparatus, and a characteristic value calculation method for irradiating a living tissue with illumination light and measuring the return light that is scattered and returned by the illumination light.
  • an optical measurement device that irradiates a living tissue with illumination light and estimates the properties of the living tissue based on the measurement value of the detection light reflected or scattered from the living tissue.
  • the optical measurement device is used in combination with an endoscope for observing an organ such as a digestive organ.
  • an optical measuring device low coherence white light with a short spatial coherence length is irradiated onto the living tissue from the tip of the irradiation fiber of the probe, and the intensity distribution of scattered light at a plurality of angles is measured using a plurality of light receiving fibers.
  • LEBS Low-Coherence Enhanced Backscattering
  • the measurement result in the optical measuring device is the endoscope. This included the effect of the observation light. Therefore, in the optical measurement device, in order to remove the influence of the endoscope observation light from the measurement result of the return light, the first period in which the output of the white light from the probe is stopped while the endoscope observation light is output; In the state in which the endoscope observation light is output, the measurement is performed in each period of the second period in which white light is output from the probe, and the endoscope is determined from the measurement result in the first period and the measurement result in the second period. Processing to remove the influence of observation light is performed.
  • an endoscopic system has adopted a control method that obtains the brightness of a captured image and changes the output amplitude and output period of endoscopic observation light in the next frame. ing.
  • a control method for example, pulse width modulation (PWM) control is known.
  • PWM pulse width modulation
  • the measurement process of the return light of the optical measurement device does not correspond to the change in the output amplitude or output period of the endoscope observation light, so the influence of the endoscope observation light is sufficiently affected by the measurement result of the return light. There were cases where it could not be removed.
  • the present invention has been made in view of the above, and is an endoscope system, an optical measurement device, and a characteristic value that can obtain highly accurate return light measurement data while reducing the influence of endoscope observation light.
  • An object is to provide a calculation method.
  • an endoscope system includes an endoscope that is inserted into a subject and images the inside of the subject, and the endoscope.
  • An endoscope light source device that outputs observation light for observing the subject and a measurement probe inserted into the subject via the endoscope, and a living tissue inside the subject
  • An optical measurement device that optically measures the characteristics of the endoscope, the endoscope, the endoscope light source device, and the optical measurement device are communicably connected to each other, and perform image processing on an image captured by the endoscope
  • a control device for controlling the output of the observation light by the endoscope light source device, wherein the optical measurement device is a probe light source unit that outputs measurement light emitted from the tip of the measurement probe, and the measurement probe Before coming back through
  • the probe light source that outputs measurement light for observing the subject and a measurement probe inserted into the subject via the endoscope, and a living tissue inside the subject
  • An optical measurement device that optically measures the characteristics of the endoscope, the endo
  • a measurement control unit for controlling the probe light source unit and the light receiving unit based on the setting, a measurement result of the light receiving unit in the first measurement period, and a measurement result of the light receiving unit in the second measurement period.
  • a calculation unit that calculates a return light of the measurement light from the measurement result of the second measurement period by using a normalization unit that is standardized as a reference and the measurement result of the first measurement period normalized by the normalization unit
  • a processing unit A characteristic value calculating unit for calculating a characteristic value relating to the biological tissue on the basis of the calculation result of the output processing section, and having a.
  • the calculation processing unit may subtract the measurement result of the first measurement period normalized by the normalization unit from the measurement result of the second measurement period.
  • the total light amount of the observation light is set so that the amount of the observation light output per unit time output from the endoscope light source device is lighted by the endoscope light source device.
  • the normalization unit performs measurement in the first measurement period so that the total amount of the observation light in the same wavelength band in the first measurement period and the second measurement period is equal to each other. It is characterized by normalizing the results.
  • the endoscope light source device includes a solid-state light emitting element that outputs pulsed light corresponding to an electric current, and the control device performs the observation light by the image processing.
  • the amount of current supplied to the solid state light emitting element and the drive timing of the solid state light emitting element are controlled based on the information on the brightness.
  • the endoscope system according to the present invention is characterized in that the endoscope light source device can sequentially output a plurality of types of light having different wavelength bands as the observation light.
  • the endoscope system according to the present invention is characterized in that the endoscope light source device outputs white light as the observation light.
  • An optical measurement apparatus includes a measurement probe inserted into the subject via an endoscope that is inserted into the subject and images the inside of the subject.
  • An endoscope light source device that outputs observation light for observing a specimen is connected to a control device that restricts the output of the observation light so as to be communicable, and optically characterizes the biological tissue inside the subject.
  • An optical measurement device for measuring comprising: a probe light source unit that outputs measurement light emitted from the tip of the measurement probe; and the observation light that returns via the measurement probe and the return light of the measurement light The probe light source unit stops outputting the measurement light and the endoscope light source device outputs the observation light based on the light receiving unit to be measured and the output instruction information of the observation light from the control device.
  • a normalization unit that normalizes a measurement result of the light receiving unit in the first measurement period based on a measurement result of the light receiving unit in the second measurement period, and a normalization unit
  • a calculation processing unit that calculates the return light of the measurement light from the measurement result of the second measurement period using the measurement result of the first measurement period, and the living body based on the calculation result of the calculation processing unit
  • a characteristic value calculation unit that calculates characteristic values related to the tissue.
  • the calculation processing unit subtracts the measurement result of the first measurement period normalized by the normalization unit from the measurement result of the second measurement period.
  • the characteristic value calculation method includes a measurement probe inserted into the subject via an endoscope that is inserted into the subject and images the inside of the subject, and the measurement probe.
  • An endoscope for outputting observation light for observing the subject comprising: a probe light source unit that outputs measurement light emitted from the tip of the light source; and a light receiving unit that receives and measures at least the return light of the measurement light
  • a characteristic value calculation method performed by an optical measurement device that is communicably connected to a control device that restricts the output of the observation light to a mirror light source device and optically measures the characteristics of a living tissue inside the subject.
  • the probe light source unit receives the observation light output instruction information for the endoscope light source device from the control device and the observation light output instruction information received in the reception step.
  • Said A first measurement period setting step for setting a first measurement period during which the output of constant light is stopped and the endoscope light source device outputs the observation light; and a process for measuring the return light of the observation light in the first measurement period
  • a second measurement period setting step for setting a second measurement period in which the probe light source unit outputs the measurement light and the endoscope light source device outputs the observation light
  • a second measurement processing step for measuring the observation light and a return light of the measurement light in a second measurement period; a measurement result of the light receiving unit in the first measurement period; and the light receiving unit in the second measurement period.
  • a calculation processing step of calculating a light Ri characterized in that it comprises a, a characteristic value calculation step of calculating a characteristic value relating to the biological tissue on the basis of the calculation result of the calculating process step.
  • the calculation processing step subtracts the measurement result of the first measurement period normalized in the normalization step from the measurement result of the second measurement period.
  • the first measurement period in which the probe light source unit stops outputting the measurement light and the endoscope light source device outputs the observation light and the probe light source unit outputs the measurement light and the endoscope light source device.
  • the second measurement period in which the observation light is output and based on the observation light output instruction information from the control device, the measurement result of the light receiving part in the first measurement period is measured in the second measurement period.
  • the return light of the measurement light is calculated from the measurement result of the second measurement period using the normalized measurement result as a reference, and the characteristics related to the living tissue based on the calculation result Since the value is calculated, highly accurate return light measurement data can be acquired with less influence of the endoscope observation light.
  • FIG. 1 is a diagram illustrating a schematic configuration of the endoscope system according to the first embodiment.
  • FIG. 2 is a block diagram schematically showing the configuration of the optical measurement device, the control device, and the endoscope light source device shown in FIG.
  • FIG. 3 is a timing chart showing the measurement light output timing in the optical measurement device shown in FIG. 2 and the observation light output timing in the endoscope light source device.
  • FIG. 4 is a timing chart showing the measurement light output timing in the conventional optical measurement apparatus and the observation light output timing in the endoscope light source apparatus.
  • FIG. 5 is a flowchart showing an outline of the biological tissue characteristic value calculation processing executed by the optical measurement apparatus shown in FIG.
  • FIG. 6 is another example of a timing chart showing the measurement light output timing in the optical measurement device shown in FIG.
  • FIG. 7 is a block diagram schematically illustrating the configuration of the optical measurement device, the control device, and the endoscope light source device that constitute the endoscope system according to the second embodiment.
  • FIG. 8 is a timing chart showing the measurement light output timing in the optical measurement device shown in FIG. 7 and the observation light output timing in the endoscope light source device.
  • FIG. 9 is a block diagram schematically illustrating the configuration of the optical measurement device, the control device, and the endoscope light source device that constitute the endoscope system according to the third embodiment.
  • FIG. 10 is a timing chart showing the measurement light output timing in the optical measurement device shown in FIG. 9 and the observation light output timing in the endoscope light source device.
  • FIG. 11 is a block diagram schematically illustrating configurations of an optical measurement device, a control device, and an endoscope light source device that configure an endoscope system according to a modification of the third embodiment.
  • FIG. 1 is a diagram illustrating a schematic configuration of an endoscope system according to the first embodiment of the present invention.
  • an endoscope system 1 according to the first embodiment is introduced into a subject, and an endoscope apparatus 2 that images the inside of the subject and generates an image signal in the subject.
  • an optical measurement device 3 that is introduced into the subject via the endoscope device 2 and optically measures the characteristics of the biological tissue in the subject, and the endoscope device 2 captures an image.
  • a control device 4 for performing predetermined image processing on the image signal and controlling each part of the endoscope system 1; an endoscope light source device 5 for generating observation light of the endoscope device 2;
  • the display device 6 displays an image corresponding to the image signal that has been subjected to image processing by the control device 4.
  • the endoscope apparatus 2 includes an insertion section 21 to be inserted into a subject, and an operation section 22 that is provided on the proximal end side of the insertion section 21 and is gripped by an operator to perform an operation input of the endoscope apparatus 2. And a flexible universal cord 23 extending from a side portion of the operation unit 22.
  • the insertion part 21 is realized using an illumination fiber (light guide cable) and an electric cable.
  • the insertion portion 21 includes a distal end portion 211 having an imaging portion incorporating a CCD sensor or a CMOS sensor as an imaging element for imaging the inside of the subject, a bending portion 212 configured by a plurality of bending pieces, and a bending portion 212. And a flexible tube portion 213 having flexibility provided on the base end side.
  • the distal end portion 211 includes an illumination unit that irradiates the inside of the subject via an illumination lens, an observation unit that images the inside of the subject, an opening 214 that communicates with the treatment instrument channel, and an air / water supply nozzle (not shown). ) Is provided.
  • the operation unit 22 includes a bending knob 221 that bends the bending unit 212 in two directions (vertical and horizontal directions) orthogonal to each other, a biopsy forceps, a laser knife, a measurement probe of the optical measurement device 3 and the like in the body cavity of the subject.
  • a switch portion 223 The treatment instrument inserted from the treatment instrument insertion section 222 is exposed from the opening 214 at the distal end of the insertion section 21 via a treatment instrument channel provided inside.
  • the universal cord 23 is configured using an illumination fiber and an electric cable.
  • the universal cord 23 transmits the observation light emitted from the endoscope light source device 5 to the distal end portion 211 via the operation portion 22 and the flexible tube portion 213.
  • the universal code 23 transmits an image signal captured by an imaging unit such as an imaging device provided at the distal end portion 211 to the control device 4.
  • the optical measurement device 3 outputs the measurement light to the measurement probe 31 inserted into the body of the subject through the treatment instrument insertion portion 222 of the endoscope device 2, and the measurement probe 31.
  • a main body 32 that receives the return light of the measurement light scattered by the object and estimates the property (characteristic value) of the measurement object; a transmission cable 33 that transmits the measurement result of the main body 32 to the control device 4; Is provided.
  • scattering includes “reflection”.
  • the control device 4 performs predetermined image processing on the image signal of the subject imaged by the distal end portion 211 of the endoscope device 2 transmitted via the universal code 23.
  • the control device 4 records the measurement result of the optical measurement device 3 transmitted via the transmission cable 33.
  • the control device 4 controls each part of the endoscope system 1 based on various instruction signals transmitted from the switch unit 223 in the operation unit 22 of the endoscope apparatus 2 via the universal cord 23.
  • the endoscope light source device 5 is configured using a white light source or a special light source.
  • the endoscope light source device 5 is an observation light (illumination light) for observing living tissue from a white light source or a special light source to the endoscope device 2 connected via the illumination fiber of the universal cord 23. Supply as.
  • the observation light is emitted from the distal end portion 211 of the insertion portion 21 of the endoscope apparatus 2.
  • the display device 6 is configured using a display using liquid crystal or organic EL (Electro Luminescence).
  • the display device 6 displays an image corresponding to an image signal subjected to predetermined image processing by the control device 4 via the video cable 61, a measurement result of the optical measurement device 3, and the like.
  • the operator can determine the observation and properties of a desired position in the subject by operating the endoscope apparatus 2 while viewing the image displayed on the display device 6.
  • FIG. 2 is a block diagram schematically showing the configuration of the optical measurement device 3, the control device 4, and the endoscope light source device 5 shown in FIG.
  • the measurement probe 31 is realized using one or a plurality of optical fibers.
  • the illumination fiber 311 that emits the measurement light (illumination light) to the living tissue S1 as the measurement object and the return light of the measurement light scattered by the measurement object are incident at different angles (scattering angles).
  • the illumination fiber 311 and the light receiving fiber 312 are arranged in parallel at least at their distal ends.
  • the measurement probe 31 has a proximal end portion 313, a flexible portion 314, and a distal end portion 315.
  • the base end portion 313 is detachably connected to the main body portion 32.
  • the flexible portion 314 has flexibility and transmits measurement light emitted from the main body portion 32 to the distal end portion 315 including the distal end where the end face of the illumination fiber 311 is exposed, and is incident through the distal end portion 315.
  • the measurement light returning light is transmitted to the main body 32.
  • the tip portion 315 emits the measurement light transmitted from the flexible portion 314 to the living tissue S1, and the return light of the measurement light scattered by the living tissue S1 enters.
  • the distal end portion 315 is provided with a permeable rod 315a as an optical member.
  • the rod 315a has a cylindrical shape so that the distance between the surface of the living tissue S1 and the tips of the illumination fiber 311 and the light receiving fiber 312 is constant.
  • the measurement probe 31 having the two light receiving fibers 312 has been described as an example. However, the measurement probe 31 only needs to receive at least two types of return lights having different scattering angles. A light receiving fiber 312 may be provided. Furthermore, the number of illumination fibers 311 included in the measurement probe 31 can be changed as appropriate according to the living tissue S1 as the measurement target.
  • the main body unit 32 includes a probe light source unit 321, a light receiving unit 322, an input unit 323, an output unit 324, a recording unit 325, a communication unit 326, and an optical control unit 327.
  • the probe light source unit 321 generates light that irradiates the living tissue S1.
  • the probe light source unit 321 functions as a probe light source unit in claims, and outputs measurement light for measuring the characteristics of the living tissue S1 via the measurement probe 31.
  • the probe light source unit 321 generates measurement light emitted to the illumination fiber 311 of the measurement probe 31.
  • the probe light source unit 321 includes a light source 321a that is a low coherent light source configured by a white LED (Light Emitting Diode) that outputs white light, and a condensing lens 321b that condenses the measurement light emitted from the light source 321a on the illumination fiber 311. And have.
  • the light receiving unit 322 receives return light of measurement light that is output from the measurement probe 31 and scattered by the living tissue S1, and observation light generated by the endoscope light source device 5 is scattered by the living tissue S1. The return light of the observation light that returns via the measurement probe 31 is received.
  • the light receiving unit 322 is realized using a plurality of spectrometers. The light receiving unit 322 measures the frequency spectrum component of the measurement light output from the measurement probe 31 and the return light of the observation light. The light receiving unit 322 outputs the measurement result to the optical control unit 327.
  • the input unit 323 is realized by using a push-type switch, a touch panel, or the like. When the switch or the like is operated, instruction information for instructing activation of the optical measuring device 3 or operation information for instructing other various operations is provided. The input is received and output to the optical control unit 327.
  • the output unit 324 is realized by using a liquid crystal or organic EL display, a speaker, and the like, and outputs information related to various processes in the optical measuring device 3.
  • the recording unit 325 is realized by using a volatile memory or a non-volatile memory, and records various programs for operating the optical measurement device 3, various data used for optical measurement processing, and various parameters.
  • the recording unit 325 temporarily records information being processed by the optical measurement device 3.
  • the communication unit 326 is a communication interface for performing communication with the control device 4 via the transmission cable 33.
  • the measurement result of the optical measuring device 3 is transmitted to the control device 4, and the instruction signal and control signal transmitted from the control device 4 are output to the optical control unit 327.
  • the optical control unit 327 is configured using a CPU (Central Processing Unit) or the like.
  • the optical control unit 327 controls the processing operation of each unit of the optical measurement device 3.
  • the optical control unit 327 controls the operation of the optical measurement device 3 by transferring instruction information and data for each component of the optical measurement device 3.
  • the optical control unit 327 records the measurement result by the light receiving unit 322 in the recording unit 325.
  • the optical control unit 327 includes a measurement control unit 327a and a calculation unit 327b.
  • the measurement control unit 327 a controls measurement light output processing by the probe light source unit 321 and measurement processing by the light receiving unit 322.
  • the calculation unit 327b performs a plurality of calculation processes based on the measurement result by the light receiving unit 322, and calculates characteristic values related to the properties of the living tissue S1. The type of the characteristic value is set according to the instruction information received by the input unit 323, for example.
  • the calculation unit 327b includes a normalization unit 327c, a calculation processing unit 327d, and a characteristic value calculation unit 327e. The measurement control unit 327a and the calculation unit 327b will be described later.
  • the control device 4 includes a connection unit 41, an image processing unit 42, an input unit 43, a recording unit 44, a communication unit 45, and a control unit 46.
  • connection unit 41 is connected to an electric cable (communication cable) 231 of the universal cord 23.
  • the connection unit 41 receives an image signal that is a digital signal imaged by the imaging unit 211b disposed in the vicinity of the observation window (not shown) of the distal end portion 211 via the electric cable 231 of the universal cord 23 and receives an image.
  • the data is output to the processing unit 42.
  • the image processing unit 42 performs predetermined image processing on the image signal output from the connection unit 41 and outputs the image signal to the display device 6. Specifically, the image processing unit 42 performs at least optical black subtraction processing, white balance (WB) adjustment processing, image signal synchronization processing, color matrix calculation processing, gamma correction on the image signal (image data). Image processing including processing, color reproduction processing, edge enhancement processing, and the like is performed.
  • the image processing unit 42 converts the image signal subjected to the image processing from a digital signal to an analog signal, changes the image signal of the converted analog signal to a format such as a high-definition method, and outputs the image signal to the display device 6. Thereby, one in-vivo image is displayed on the display device 6.
  • the input unit 43 is realized using an operation device such as a mouse, a keyboard, and a touch panel, and receives input of various instruction information of the endoscope system 1. Specifically, the input unit 43 receives input of various instruction information such as subject information, identification information of the endoscope apparatus 2 and examination contents.
  • the recording unit 44 is realized by using a volatile memory or a non-volatile memory, and records various programs for operating the control device 4 and the endoscope light source device 5.
  • the recording unit 44 temporarily records information being processed by the control device 4.
  • the recording unit 44 records the image signal subjected to the image processing by the image processing unit 42 and the measurement result of the optical measuring device 3.
  • the recording unit 44 may be configured using a memory card or the like mounted from the outside of the control device 4.
  • the communication unit 45 is a communication interface for performing communication with the optical measurement device 3 via the transmission cable 33.
  • the control unit 46 is realized using a CPU or the like.
  • the control unit 46 controls the processing operation of each unit of the control device 4.
  • the control unit 46 controls the operation of the control device 4 by transferring instruction information and data to each component of the control device 4.
  • the control unit 46 is connected to each of the endoscope apparatus 2, the optical measurement apparatus 3, and the endoscope light source apparatus 5 through each cable.
  • the controller 46 controls the output of observation light with respect to the endoscope light source device 5.
  • the endoscope light source device 5 includes a light source unit 51, a rotary filter 52, a condenser lens 53, a light source driver 54, a motor 55, a motor driver 56, and a light source drive control unit 57.
  • the light source unit 51 is configured using a white LED.
  • the light source unit 51 generates observation light (illumination light) to be supplied to the endoscope apparatus 2.
  • the white LED is a solid-state light emitting element that outputs pulsed light corresponding to the current flowing through the white LED.
  • the light source unit 51 may be configured using a white xenon lamp.
  • the rotary filter 52 has a flat plate shape, is disposed on the optical path of white light emitted from the light source unit 51, and rotates to transmit only light having a predetermined wavelength band among observation light emitted from the light source unit 51.
  • the rotary filter 52 includes a red filter 521, a green filter 522, and a blue filter 523 that transmit light having wavelength bands of red light (R), green light (G), and blue light (B).
  • the rotary filter 52 sequentially transmits light having red, green, and blue wavelength bands (for example, red: 600 nm to 700 nm, green: 500 nm to 600 nm, blue: 400 nm to 500 nm) by rotating.
  • the white light emitted from the light source unit 51 can sequentially emit any one of the narrow-band red light, green light, and blue light to the endoscope apparatus 2. Therefore, the endoscope light source device 5 can sequentially output observation light having different wavelength bands.
  • the condensing lens 53 is disposed on the optical path of white light emitted from the light source unit 51, condenses the light transmitted through the rotary filter 52, and emits it to the illumination fiber 232 that is a light guide cable of the universal cord 23.
  • the light source driver 54 supplies predetermined power to the light source unit 51 under the control of the light source drive control unit 57. Thereby, the light emitted from the light source unit 51 is irradiated to the outside from the illumination unit 211 a of the distal end portion 211 of the insertion unit 21 via the illumination fiber 232.
  • the motor 55 is configured using a stepping motor, a DC motor or the like, and rotates the rotary filter 52.
  • the motor driver 56 supplies predetermined power to the motor 55 under the control of the light source drive control unit 57.
  • the light source drive control unit 57 controls the amount of current supplied to the light source unit 51 and driving of the rotary filter 52 based on the drive signal transmitted from the control unit 46 under the control of the control unit 46.
  • the return light is controlled by controlling the measurement light output processing by the probe light source unit 321 and the measurement processing by the light receiving unit 322 in synchronization with the output of the observation light from the light source unit 51. From this measurement result, the influence of the endoscope observation light is sufficiently removed, so that highly accurate return light measurement data can be obtained without the influence of the endoscope observation light.
  • control unit 46 outputs observation light output instruction information that instructs the endoscope light source device 5 to output observation light to the light source drive control unit 57 of the endoscope light source device 5. Is used to control the output of observation light in the endoscope light source device 5 and transmit the observation light output instruction information to the communication unit 326 of the optical measurement device 3 via the communication unit 45.
  • the communication unit 326 receives observation light output instruction information for the endoscope light source device 5 by the control unit 46.
  • the measurement control unit 327a is configured to cause the light receiving unit 322 to perform measurement (first measurement processing) based on the observation light output instruction information received by the communication unit 326, and A second measurement period for setting the light receiving unit 322 to perform measurement (second measurement process) is set.
  • first measurement processing the measurement light from the probe light source unit 321
  • second measurement process the measurement light from the probe light source unit 321 is output.
  • the normalization unit 327c performs measurement in the first measurement period by the light receiving unit 322 in the same wavelength band based on the measurement results (the measurement result of the first measurement period and the measurement result of the second measurement period) by the light receiving unit 322.
  • the measurement results in the first measurement period are normalized so that the total amount of observation light (total area of pulses) is equal to the total amount of observation light measured by the light receiving unit 322 in the second measurement period.
  • the total amount of observation light is obtained by multiplying the amount of observation light output per unit time output from the endoscope light source device 5 by the time during which the endoscope light source device 5 is lit.
  • the calculation processing unit 327d calculates the return light of the measurement light from the measurement result of the second measurement period, using the measurement result of the first measurement period normalized by the normalization unit 327c. For example, the calculation processing unit 327d calculates the return light of the measurement light by subtracting the measurement result of the first measurement period normalized by the normalization unit 327c from the measurement result of the second measurement period.
  • the characteristic value calculation unit 327e calculates a characteristic value related to the living tissue S1 based on the calculation result of the calculation processing unit 327d.
  • FIG. 3 is a timing chart showing the measurement light output timing in the optical measurement device 3 and the observation light output timing in the endoscope light source device 5.
  • FIG. 3A is a timing chart showing the output timing of the observation light in the endoscope light source device 5
  • FIG. 3B is a timing chart showing the output timing of the measurement light in the optical measurement device 3.
  • 3A and 3B the horizontal axis indicates time.
  • the control unit 46 transmits observation light output instruction information for periodically and sequentially outputting light of each wavelength band of red, green, and blue with the same amplitude to the light source drive control unit 57 of the endoscope light source device 5. To do. As a result, as shown in FIG. 3 (a), the endoscope light source device 5 sequentially outputs red light, green light, and blue light with a constant amplitude La at a constant cycle Ps as shown in FIG. The The period Ps is equal to the time when an image of one frame is captured.
  • the control unit 46 also transmits the observation light output instruction information to the communication unit 326 of the optical measurement device 3 via the communication unit 45. Based on the observation light output instruction information received by the communication unit 326, the measurement control unit 327a synchronizes with the period Ps of the observation light output from the endoscope light source device 5 to the probe light source unit 321.
  • the probe light source unit 321 turns off the measurement light output in the output stop period Pa that coincides with the observation light period Ps, while the light receiving unit 322 performs the first response to the return light in the output stop period Pa. Perform the measurement process.
  • the measurement control unit 327a synchronizes with the period Ps of the observation light output from the endoscope light source device 5 next, and outputs the measurement light output period Pb between the period Ps and the synchronization with respect to the probe light source unit 321.
  • the measurement control unit 327a sets the measurement light output period Pb as the second measurement period in which the light receiving unit 322 performs the second measurement process.
  • the probe light source unit 321 turns on the output of the measurement light in the output period Pb that coincides with the period Ps of the next observation light, while the light receiving unit 322 performs the second measurement on the return light in the output period Pb.
  • the measurement control unit 327a repeatedly sets the output stop period Pa and the first measurement period, and the output period Pb and the second measurement period in synchronization with the period Ps of the observation light output from the endoscope light source device 5.
  • the endoscope light source device 5 has a constant amplitude La for each period of synchronization and each wavelength band of red light, green light and blue light as shown in FIG.
  • the light is output at a constant period Ps while sequentially repeating light. Therefore, when comparing light in the same wavelength band, the total amount of return light of the observation light measured by the light receiving unit 322 in the first measurement period is equal to the total amount of return light of the observation light in the second measurement period. It is.
  • the normalization unit 327c only has to multiply the total light amount in each wavelength band measured by the light receiving unit 322 in the first measurement period by one. In the first embodiment, the normalization unit 327c simply multiplies the total light amount in the first measurement period, so that it is possible not to perform the normalization process.
  • the calculation processing unit 327d subtracts the measurement result in the first measurement process in the first measurement period from the measurement result in the second measurement process in the second measurement period, thereby obtaining one cycle Ps. Only the return light from the surrounding living tissue S1 is acquired.
  • the characteristic value calculation unit 327e calculates a characteristic value related to the biological tissue S1 based on the return light from the biological tissue S1 per cycle Ps acquired by the calculation processing unit 327d.
  • the conventional light source measurement device outputs the measurement light in a period Pap from time t11 to time t12 at a timing different from the period Ps (see FIG. 4A).
  • the light receiving unit was turned off to perform measurement processing, and the measurement light output was turned on in the period Pbp from time t12 to time t13 to cause the light receiving unit to perform measurement processing (see FIG. 4B).
  • the influence of the observation light included in the measurement result of the period Pap and the influence of the observation light included in the measurement result of the period Pbp cannot be regarded as the same, and the measurement result of the period Pap is determined from the measurement result of the period Pbp. In some cases, the influence of the endoscopic observation light cannot be sufficiently removed even if the value is subtracted.
  • the measurement control unit 327a synchronizes with the output of the observation light from the light source unit 51 of the endoscope light source device 5, and outputs the measurement light from the probe light source unit 321.
  • the influence of the observation light included in the measurement result of the first measurement process in the measurement light output stop period Pa and the measurement result of the measurement light output period Pb are included.
  • the effect of the observed light is the same.
  • the calculation processing unit 327d subtracts the measurement result of the first measurement period from the measurement result of the second measurement period, thereby returning only the return light from the living tissue S1 per cycle Ps. To get. Therefore, according to the optical measurement device 3 in the first embodiment, by accurately removing the influence of the endoscope observation light from the measurement result of the return light, the influence of the endoscope observation light is reduced and highly accurate. Return light measurement data can be acquired.
  • FIG. 5 is a flowchart showing an outline of a biological tissue characteristic value calculation process executed by the optical measurement apparatus 3 shown in FIG.
  • the optical control unit 327 receives the characteristic calculation instruction information for instructing the calculation of the characteristic value of the living tissue from the input unit 323 (step S1). Subsequently, the communication unit 326 receives observation light output instruction information for instructing the next observation light output process for the endoscope light source device 5 from the control unit 46 of the control device 4 (step S2). Based on the observation light output instruction information received by the communication unit 326, the measurement control unit 327a performs measurement by the probe light source unit 321 in synchronization with the period of the observation light output next from the endoscope light source device 5. While stopping the output of light, the 1st measurement period which makes the light-receiving part 322 perform a 1st measurement process is set (step S3).
  • the probe light source unit 321 performs measurement light stop processing for stopping the output of measurement light (step S4), and the light receiving unit 322 performs measurement control in step S3.
  • the first measurement process is executed during the first measurement period set by the unit 327a (step S5).
  • the result of the first measurement process is recorded in the recording unit 325 by the optical control unit 327.
  • the communication unit 326 receives observation light output instruction information for instructing the next observation light output process for the endoscope light source device 5 from the control unit 46 of the control device 4 (step S6). Based on the observation light output instruction information received by the communication unit 326, the measurement control unit 327a performs measurement by the probe light source unit 321 in synchronization with the period of the observation light output next from the endoscope light source device 5. While outputting light, the 2nd measurement period which makes the light-receiving part 322 perform a 2nd measurement process is set (step S7).
  • the probe light source unit 321 performs measurement light output processing for outputting measurement light (step S8), and the light receiving unit 322 is set by the measurement control unit 327a in step S7.
  • the second measurement process is executed (step S9). Note that the result of the second measurement process is recorded in the recording unit 325 by the optical control unit 327.
  • the normalization unit 327c in the same wavelength band, the total amount of observation light measured by the light receiving unit 322 during the first measurement period and the total amount of observation light measured by the light receiving unit 322 during the second measurement period.
  • the measurement results in the first measurement period are normalized so that the amount of light is equal (step S10). Note that, as described above, in the first embodiment, the normalization unit 327c simply doubles the total light amount in the first measurement period, and thus the normalization process may not be performed.
  • the calculation processing unit 327d performs measurement return light calculation processing for calculating the return light of the measurement light from the measurement result of the second measurement period using the measurement result of the first measurement period normalized by the normalization unit 327c.
  • step S11 the component of the return light from the living tissue per cycle of the observation light from the endoscope light source device 5 is acquired.
  • the measurement return light calculation process is a subtraction process in which the measurement result in the first measurement period is subtracted from the measurement result in the second measurement period.
  • the characteristic value calculation unit 327e performs a characteristic value calculation process for calculating a characteristic value related to the living tissue based on the return light from the living tissue per cycle acquired by the calculation processing unit 327d (step S12). .
  • the optical control unit 327 outputs the characteristic value output by the characteristic value calculation unit 327e to the output unit 324, and ends the biological tissue characteristic value calculation processing.
  • the optical control unit 327 may record the characteristic value output from the characteristic value calculation unit 327e in the recording unit 325, or may output the characteristic value to the control device 4 via the communication unit 326.
  • the optical measuring device 3 performs the endoscope observation by performing each of the steps S1 to S12 shown in FIG. 5 synchronized with the output of the observation light from the light source unit 51 of the endoscope light source device 5. It is possible to obtain highly accurate return light measurement data that eliminates the influence of light.
  • the measurement control unit 327a has the wavelength band of the observation light output from the endoscope light source device 5 so that the measurement light output stop period of the probe light source unit 321 and the measurement light of the probe light source unit 321 are measured. What is necessary is just to control the probe light source part 321 and the light-receiving part 322 so that it may become the same in an output period. For this reason, in the first embodiment, the first measurement period and the second measurement period do not have to coincide with the period Ps of the observation light output from the endoscope light source device 5.
  • the optical control unit 327 is configured so that the components of the observation light included in each of the first measurement period Pc and the second measurement period Pd are a combination of red light and green light. You may control the probe light source part 321 and the light-receiving part 322 (refer FIG.6 (b)).
  • the optical control unit 327 performs measurement processing on the light receiving unit 322 according to the timing chart illustrated in FIG. 6B while outputting the measurement light to the probe light source unit 321 according to the timing chart illustrated in FIG. You may control so that it may.
  • the optical control unit 327 causes the light receiving unit 322 to perform measurement processing continuously in time series, and the measurement result corresponding to the first measurement period Pc is obtained from the obtained measurement results (time series data). Obtained as a measurement result of the first measurement process, obtains a measurement result corresponding to the second measurement period Pd as a measurement result of the second measurement process, and causes each component of the computation unit 327b to perform the computation process. Also good.
  • the endoscope light source device 5 sequentially emits red light, green light, and blue light to the endoscope device 2 has been described as an example.
  • light in two narrow bands of green light and blue light that are easily absorbed by hemoglobin in the blood may be sequentially emitted.
  • FIG. 7 is a block diagram schematically illustrating the configuration of the optical measurement device, the control device, and the endoscope light source device that constitute the endoscope system according to the second embodiment.
  • the endoscope system 201 according to the second embodiment includes an optical measurement device 203, a control device 204, and an endoscope light source device 205.
  • the optical measurement device 203 includes a measurement probe 31 and a main body 2031.
  • the main body 2031 and the control device 204 are connected via the transmission cable 33 in the same manner as the connection between the main body 32 and the control device 4 shown in FIG.
  • the endoscope light source device 205 has a configuration in which the rotary filter 52, the motor 55, and the motor driver 56 are deleted from the endoscope light source device 5 shown in FIG.
  • the endoscope light source device 205 includes a light source unit 251 configured using a white LED that outputs white light, a light source driver 254 that supplies predetermined power to the light source unit 251, and an amount of current supplied to the light source unit 251.
  • a light source drive control unit 257 for controlling. Under the control of the control unit 246, the endoscope light source device 205 generates white light so that the amplitude is a constant value and the duty ratio, which is the ratio of the pulse width to the pulse period, is a constant value. Output as observation light.
  • control device 204 includes a control unit 246 that outputs observation light output instruction information for the endoscope light source device 205 and performs output control of the observation light.
  • control unit 246 outputs observation light output instruction information for outputting white light with a constant duty ratio and outputting white light with a constant duty ratio to the endoscope light source device 205.
  • the optical measuring device 203 includes an optical control unit 2327 having the same function as the optical control unit 327 shown in FIG.
  • the optical control unit 2327 performs the same processing as the measurement control unit 327a using the observation light output instruction information transmitted from the control unit 246 and instructing the output of white light with a constant amplitude and a constant duty ratio. It has a measurement control unit 2327a and a calculation unit 2327b that performs the same processing as the calculation unit 327b.
  • the calculation unit 2327b includes a normalization unit 2327c, a calculation processing unit 2327d, and a characteristic value calculation unit 2327e.
  • the endoscope light source device 205 uses the observation light output instruction information from the control unit 246 as the observation light as shown in FIG.
  • White light is periodically output with an amplitude Lb and a constant duty ratio.
  • FIG. 8A the following description will be given with the white light output period for two frames as a unit period Pt.
  • the measurement control unit 2327a is synchronized with the unit period Pt of white light output as observation light from the endoscope light source device 205.
  • a measurement light output stop period Pe between the unit period Pt and the same period is set.
  • the measurement control unit 2327a sets the measurement light output stop period Pe as a first measurement period in which the light receiving unit 322 performs the first measurement process.
  • the probe light source unit 321 turns off the output of the measurement light in the output stop period Pe that coincides with the unit period Pt of the observation light.
  • the light receiving unit 322 performs the first measurement on the return light. Process. Therefore, the measurement result of the first measurement process of the light receiving unit 322 in the output stop period Pe is the total amount of the return light of the observation light output per unit period Pt.
  • the measurement control unit 2327a synchronizes with the unit period Pt of white light from the endoscope light source device 205 to be output next, and transmits the measurement light between the unit period Pt and the synchronization to the probe light source unit 321.
  • An output period Pf is set.
  • the measurement control unit 2327a sets the measurement light output period Pf as the second measurement period in which the light receiving unit 322 performs the second measurement process.
  • the probe light source unit 321 turns on the measurement light output in the output period Pf that coincides with the unit period Pt of the next observation light, and during this output period Pf, the light receiving unit 322 performs the second operation on the return light. Perform the measurement process.
  • the measurement result of the second measurement process of the light receiving unit 322 in the output period Pf is the total light amount of the observation light and the return light of the measurement light output per unit period Pt.
  • the normalization unit 2327c is measured during the first measurement period by the light receiving unit 322 in the same wavelength band based on the measurement results by the light receiving unit 322 (the measurement result of the first measurement period and the measurement result of the second measurement period).
  • the measurement result in the first measurement period is normalized so that the total light quantity of the observed light and the total light quantity of the observation light measured in the second measurement period by the light receiving unit 322 are equal.
  • the normalization unit 2327c uses the total light amount measured by the light receiving unit 322 as 1 in the first measurement period. Double. In this sense, also in the second embodiment, as in the first embodiment, it is possible not to perform the normalization process in the normalization unit 2327c.
  • the calculation unit 2327b is configured so that the calculation processing unit 2327d subtracts the measurement result of the first measurement period by the light receiving unit 322 from the measurement result of the second measurement period by the light receiving unit 322, thereby calculating the biological tissue S1 per unit period Pt. Only get the return light.
  • the characteristic value calculation unit 2327e calculates a characteristic value related to the living tissue S1 based on the return light from the living tissue S1 per unit period Pt acquired by the calculation processing unit 2327d.
  • the optical measurement device 203 does not transmit the observation light of the light source unit 251.
  • the influence of the observation light included in the measurement result of the first measurement process in the measurement light output stop period Pe and the influence of the observation light included in the measurement result of the measurement light output period Pf are made identical. By doing so, as in the first embodiment, the influence of the endoscope observation light can be sufficiently removed from the measurement result of the return light.
  • the outline of the biological tissue characteristic value calculation process executed by the optical measurement device 203 is the same as the outline of the biological tissue characteristic value calculation process executed by the optical measurement apparatus 3 in the first embodiment ( (See FIG. 5).
  • FIG. 9 is a block diagram schematically illustrating the configuration of the optical measurement device, the control device, and the endoscope light source device that constitute the endoscope system according to the third embodiment.
  • the endoscope system 301 according to the third embodiment includes an optical measurement device 203, a control device 304, and an endoscope light source device 205.
  • the control device 304 includes a control unit 346 that outputs observation light output instruction information to the endoscope light source device 205 and performs output control of observation light.
  • the image processing unit 42 obtains the brightness of the observation light output from the endoscope light source device 205 by processing the image signal generated by the imaging unit 211b, and information about the brightness (brightness information). Is output to the control unit 346.
  • the control unit 346 Based on the brightness information of the observation light of the endoscope light source device 205 during the previous image processing period obtained by the image processing unit 42, the control unit 346 applies the white light to the white LED of the next endoscope light source device 205.
  • the output of observation light is PWM controlled by controlling the amount of current supplied and the drive timing.
  • the control unit 346 determines a duty ratio in the output period of white light to be output next from the endoscope light source device 205. Then, the control unit 346 outputs observation light output instruction information for instructing the duty ratio in the next observation light output period, controls the amount of power supplied from the light source driver 254 to the light source unit 251, and also the light source driver 254. Controls the drive timing for driving the light source unit 251.
  • the measurement control unit 2327a In the optical control unit 2327, the measurement control unit 2327a generates white light from the endoscope light source device 205 based on the duty ratio of the observation light indicated by the observation light output instruction information transmitted from the control unit 346.
  • the measurement light output stop period and the measurement light output period in the probe light source unit 321 and the first measurement process and the second measurement process in the light receiving unit 322 are controlled so as to be synchronized with the output period.
  • the normalization unit 2327c determines that the total amount of observation light measured by the light receiving unit 322 in the first measurement period is based on the duty ratio of the observation light instructed by the observation light output instruction information in the second measurement period.
  • the measurement result in the first measurement period is normalized so as to be equal to the total light amount of the observation light.
  • FIG. 10 is a timing chart showing the measurement light output timing in the optical measurement device 203 and the observation light output timing in the endoscope light source device 205.
  • FIG. 10 shows a case where the optical measuring device 203 outputs white light having a constant amplitude Tb with a constant period T for a time (width) determined for each period.
  • the measurement light is switched on and off for each period in which white light for two frames is output.
  • the control unit 346 instructs the light source drive control unit 257 of the endoscope light source device 205 on the duty ratio of white light in each frame based on the brightness information received from the image processing unit 42.
  • To output observation light output instruction information The light source drive control unit 257 outputs white light while changing the duty ratio in each frame based on the observation light output instruction information received from the control unit 346.
  • the observation light output instruction information is also transmitted to the optical measurement device 203 via the communication unit 45.
  • the measurement control unit 2327a causes the light receiving unit 322 to perform the first measurement process based on the observation light output instruction information, and the light receiving unit 322 performs the second measurement process.
  • a second measurement period Ph for performing the above is set.
  • the measurement result of the light receiving unit 322 in the first measurement period Pg is the total light amount of the return light of the observation light output in the first measurement period Pg.
  • the measurement result of the light receiving unit 322 in the second measurement period (output period) Ph is the total light amount of the observation light and the return light of the measurement light output in the second measurement period Ph.
  • the normalization unit 2327c performs the first measurement period. Therefore, the influence of the endoscope observation light can be accurately removed from the return light measurement result.
  • the outline of the biological tissue characteristic value calculation process executed by the optical measurement device 203 is the same as the biological tissue characteristic value calculation process executed by the optical measurement device 3 in the first embodiment (FIG. 5). See).
  • the control unit 346 since the control unit 346 performs PWM control, the observation light output instruction information received by the communication unit 326 in step S2 includes duty ratio information.
  • the normalization unit 2327c performs normalization according to the above-described equation (1).
  • the control unit 346 adjusts the output amplitude of the observation light by adjusting the aperture of the xenon lamp, and information on the aperture adjustment. May be transmitted to the optical measurement device 203 as information for normalizing the measurement result of the first measurement process.
  • FIG. 11 is a block diagram schematically illustrating configurations of an optical measurement device, a control device, and an endoscope light source device that configure an endoscope system according to a modification of the third embodiment.
  • the endoscope system 401 according to the modification of the third embodiment includes an optical measurement device 403, a control device 404, and an endoscope light source device 405.
  • the endoscope light source device 405 includes a light source unit 451 that sequentially switches a plurality of lights having different wavelength bands and outputs them as observation light.
  • the light source unit 451 includes a red LED 451 a that emits red light, a green LED 451 b that emits green light, a blue LED 451 c that emits blue light, and a condenser lens 53.
  • the endoscope light source device 405 includes a light source driver 454 that supplies predetermined power to the light source unit 451 and a light source drive control unit 457 that controls the amount of current supplied to the light source unit 451.
  • the control device 404 includes a control unit 446 that outputs observation light output instruction information to the endoscope light source device 405 and performs PWM control of the observation light output. Based on the brightness information input from the image processing unit 42, the control unit 446 outputs observation light output instruction information that indicates the duty ratio of light in each wavelength band by the red LED 451a, the green LED 451b, and the blue LED 451c, While controlling the electric energy which the light source driver 454 supplies to the light source part 451, the light source driver 454 controls the drive timing which drives the light source part 451.
  • the normalization process performed by the normalization unit 327c of the optical measurement device 403 for each wavelength band is the same as the normalization process performed by the normalization unit 2327c of the optical measurement device 203 for white light.

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Abstract

　L'invention concerne un système d'endoscope (1) dans lequel un dispositif de mesure optique (3) comprend : une unité de commande de mesure (327a) pour régler, sur la base d'informations d'instruction de sortie de lumière de visualisation pour un dispositif de source de lumière d'endoscope (5) provenant d'un dispositif de commande (4), une première période de mesure dans laquelle une unité de source de lumière de sonde (321) interrompt la sortie de lumière de mesure, et le dispositif de source de lumière d'endoscope (5) délivre la lumière de visualisation, et une seconde période de mesure dans laquelle l'unité de source de lumière de sonde (321) délivre une lumière de mesure, et le dispositif de source de lumière d'endoscope (5) délivre la lumière de visualisation, et commander l'unité de source de lumière de sonde (321) et une unité de réception de lumière (322) sur la base du réglage; une unité de normalisation (327c) pour normaliser le résultat de mesure de l'unité de réception de lumière (322) dans la première période de mesure en utilisant le résultat de mesure de l'unité de réception de lumière (322) dans la seconde période de mesure comme référence; une unité de traitement de calcul (327d) pour calculer une lumière de retour de la lumière de mesure à partir du résultat de mesure de la seconde période de mesure en utilisant le résultat de mesure de la première période de mesure normalisé par l'unité de normalisation (327c); et une unité de calcul de valeur caractéristique (327e) pour calculer une valeur caractéristique associée à un tissu biologique sur la base du résultat de calcul de l'unité de traitement de calcul (327d).
PCT/JP2015/065867 2014-06-03 2015-06-02 Système d'endoscope, dispositif de mesure optique, et procédé de calcul de valeur caractéristique WO2015186691A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013133341A1 (fr) * 2012-03-07 2013-09-12 オリンパス株式会社 Dispositif de mesure optique
WO2013154061A1 (fr) * 2012-04-10 2013-10-17 オリンパスメディカルシステムズ株式会社 Dispositif de mesure optique et système endoscopique
JP5379932B1 (ja) * 2012-04-16 2013-12-25 オリンパスメディカルシステムズ株式会社 撮像システム、撮像方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013133341A1 (fr) * 2012-03-07 2013-09-12 オリンパス株式会社 Dispositif de mesure optique
WO2013154061A1 (fr) * 2012-04-10 2013-10-17 オリンパスメディカルシステムズ株式会社 Dispositif de mesure optique et système endoscopique
JP5379932B1 (ja) * 2012-04-16 2013-12-25 オリンパスメディカルシステムズ株式会社 撮像システム、撮像方法

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