WO2015182840A1

WO2015182840A1 - Method for preparing monodispersed iron oxide nanoparticles using super-high pressure homogenizer and monodispersed iron oxide nanoparticles prepared thereby

Info

Publication number: WO2015182840A1
Application number: PCT/KR2014/011747
Authority: WO
Inventors: 조준희; 김현효
Original assignee: (주)일신오토클레이브
Priority date: 2014-05-30
Filing date: 2014-12-03
Publication date: 2015-12-03
Also published as: KR101480169B1

Abstract

The present invention relates to a method for preparing monodispersed iron oxide nanoparticles using a super-high pressure homogenizer and monodispersed iron oxide nanoparticles prepared thereby. More specifically, the present invention relates to a method for preparing monodispersed iron oxide nanoparticles using a super-high pressure homogenizer, the method comprising the steps of: a) mixing an iron oxide precursor, distilled water, and a precipitant solution to prepare an iron hydroxide solution, and then passing the iron hydroxide solution through a super-high pressure homogenizer at a pressure of 500-2,000 bar at room temperature to obtain a precipitate; and b) washing the precipitate obtained in step a), followed by drying, and to monodispersed iron oxide nanoparticles prepared thereby.

Description

Method for producing monodisperse iron oxide nanoparticles using ultra high pressure homogenizer and monodisperse iron oxide nanoparticles prepared accordingly

The present invention relates to a method for producing monodisperse iron oxide nanoparticles using an ultrahigh pressure homogenizer, and monodisperse iron oxide nanoparticles prepared accordingly. More specifically, the present invention relates to a method for producing monodisperse iron oxide nanoparticles having a particle size of 10 to 30 nm using an ultrahigh pressure homogenizer, and monodisperse iron oxide nanoparticles prepared according to the present invention. , Magneto-optical device, magnetic ink, heavy metal wastewater treatment, MRI contrast agent, drug delivery system and heat treatment, etc.

When the particles are reduced to nanometer size, they exhibit new electrical, optical or magnetic properties that did not appear at bulk size. Unlike nanoparticles, nanoparticles have a large proportion of the surface, and the surface ratio depends on the size of the particles. Therefore, the size of the nanoparticles is the most important factor in determining physical and chemical properties.

In the case of iron oxide nanoparticles, when the particle size falls below a certain critical size, it becomes a single magnetic domain, where the iron oxide particles have superparamagnetism, and the kinetic energy rather than the attractive force between the particles is increased. Increase to disperse in a suitable solvent to form a stable colloidal state However, it is not easy to control the size of iron oxide nanoparticles by conventional methods of preparing nanoparticles such as sol-gel method, coprecipitation method, pyrolysis of organometallic precursor, high temperature oxidation / reduction of metal ions and precipitation, oxidation / reduction in reverse micelles. However, the particle size distribution ranges from a few nm to several hundred nm, so the magnetic properties and structural studies according to the iron oxide size have not been accurate until recently.

In addition, methods such as pyrolysis of organometallic precursors and high temperature oxidation and reduction of metal ions require a more efficient and uniform method of synthesizing iron oxide nanoparticles because the reaction takes place at a high temperature and the process is complicated.

First, J. AM. Chem. Soc. 2001, 123, 12798 discloses a method for synthesizing uniform magnetic iron oxide nanoparticles without the size selection process from pyrolysis of iron-oleic acid complexes made from the reaction of pentacarbonyl iron with oleic acid. However, there is a problem that the production temperature is high and the production time is long, such as iron oxide manufacturing temperature is more than 100 ℃, the reaction takes a total of three hours or more in two steps. In addition, the method is not suitable for the production of iron oxide nanoparticles because Fe (CO) ₅ used as a raw material for producing iron oxide is very toxic, expensive and difficult to store.

Secondly, Korean Patent Publication No. 10-2006-0012346 (2006.02.08.) Discloses a method for synthesizing nanomagnetic particles having a uniform size from pyrolysis of an iron-oleate complex made from a reaction of ferrous chloride and sodium oleate. Started. However, there is a problem in that the manufacturing temperature is high and the process is complex, such as iron oxide manufacturing temperature is more than 300 ℃, and to reduce the pressure to 0.3 Torr.

Third, Journal of Alloys and Compouns, 2009, 475, 898 describes the synthesis of magnetite nanoparticles from hydrothermal synthesis by adding hydrogen peroxide as an oxidant to ferrous hydroxide (Fe (OH) ₂ ), which is made by adding ammonia water to ferrous sulfate solution. Started. However, due to the high production temperature and long production time, such as ferrous hydroxide solution by adding polyethyleneglycol polymer as a dispersant and hydrogen peroxide as an oxidizer, it is subjected to hydrothermal synthesis at 160 ° C for 5-8 hours. It was not effective in production.

Therefore, the inventors of the present invention while studying to solve the problems of the complicated process at a high temperature, a long manufacturing time, a wide particle size distribution of the particles, the use of toxic surfactants and oxidants, which is a disadvantage of the conventional iron oxide nanoparticle manufacturing method The synthesis method through a homogenizer has developed a method for producing monodisperse iron oxide nanoparticles which can economically prepare iron oxide nanoparticles having excellent crystallinity and uniform size in a simple process at room temperature, and completed the present invention.

An object of the present invention is to solve the above problems, by passing the iron hydroxide solution to the ultra-high pressure homogenizer, does not require the iron oxide nanoparticle separation process, the process is simplified, the process time is shortened and at the same time using an environmentally friendly ultra-high pressure homogenizer It is to provide a method for producing monodisperse iron oxide nanoparticles and monodisperse iron oxide nanoparticles prepared accordingly.

Another object of the present invention is to provide a method for producing monodisperse iron oxide nanoparticles using ultra-high pressure homogenizer which can economically produce iron oxide nanoparticles having excellent crystallinity and uniform size, and monodisperse iron oxide nanoparticles prepared accordingly. It is.

It is still another object of the present invention to provide a method for preparing monodisperse iron oxide nanoparticles using a radical reaction of an ultrahigh pressure homogenizer without the addition of a separate oxidizing agent, a surfactant and a radical scavenger, and monodisperse iron oxide nanoparticles prepared accordingly.

The present invention relates to a method for producing monodisperse iron oxide nanoparticles and monodisperse iron oxide nanoparticles prepared accordingly.

Reference may be made to FIG. 1 as an example of the ultrahigh pressure homogenizer in the present invention.

The ultrahigh pressure homogenizer of FIG. 1 may include a sample inlet, a pressure pump for applying pressure to a fluid, a fine orifice nozzle chamber, a heat exchanger, and an outlet.

The pressure pump may move the fluid to the micro orifice nozzle chamber by applying pressure to the fluid.

Figure 2 below shows a part of the interior of the micro orifice nozzle chamber. In one embodiment of the present invention, when water is passed through the chamber, OH radicals generated by dissociation of water molecules and their combinations produce H ₂ O ₂ , an oxidizing agent, and monodisperse iron oxide nanoparticles without the addition of an additional oxidizing agent. Can be prepared. In addition, the heat exchanger may serve to cool some heat generated when the fluid passes through the chamber.

Hereinafter, a method for producing monodisperse iron oxide nanoparticles using the ultrahigh pressure homogenizer of the present invention will be described in detail.

Method for producing monodisperse iron oxide nanoparticles using an ultrahigh pressure homogenizer of the present invention,

a) preparing an iron hydroxide solution by mixing the iron oxide precursor, distilled water and a precipitant solution, and then passing the ultra-high pressure homogenizer at a pressure of 500 to 2,000 bar at room temperature to obtain a precipitate, and

b) washing and drying the precipitate of step a),

It includes.

Since the monodisperse iron oxide nanoparticles of the present invention are manufactured by the above-described manufacturing method, the separation process of the monodisperse iron oxide nanoparticles is not necessary, so the process is simplified, the process time is shortened, and the iron oxide nanoparticles of uniform size with excellent crystallinity It is characterized in that it is prepared.

In addition, the present invention is characterized by the production of monodisperse iron oxide nanoparticles by simplifying the process and shortening the process time by using a radical reaction by an ultrahigh pressure homogenizer without adding an additional oxidant and hydrothermal synthesis.

The iron hydroxide solution of step (a) may be prepared by dissolving the iron oxide precursor in distilled water to prepare a precursor aqueous solution, and then adding a precipitant solution.

The iron oxide precursor may be any one or two or more selected from the group consisting of, for example, ferrous chloride (FeCl ₂ ), ferrous sulfate (FeSO ₄ ), and iron acetate (Fe (CH ₃ COO) ₂ ). Can be used.

The concentration of the precursor aqueous solution may determine the size and uniformity of the particles. Therefore, it is preferable that it is 0.01-5 mol, It is preferable that it is 0.1-1 mol more preferably.

The precipitant solution is used to prepare Fe (OH) ₂ precipitate using Fe ²⁺ ion solution. Specifically, for example, any one or two or more selected from the group consisting of ammonia water, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, tetramethylammonium, and the like can be used, and the price is low, and the pH control is Sodium hydroxide is the easiest to use.

It is preferable to adjust the iron hydroxide solution to basic using the precipitant solution, preferably to adjust the pH to 9 to 13, more preferably to 10 to 12. When the pH of the iron hydroxide solution is 9 or less, Fe ²⁺ may remain in some Fe ²⁺ state without changing to Fe (OH) ₂ , and if the pH exceeds 13, the number of washing increases the pH Is preferably in the above range.

When the iron hydroxide solution is added to the inlet of the sample in step (a), it can automatically flow into the pressure pump, and the pressure pump can serve to move the iron hydroxide solution to the fine orifice nozzle chamber.

The fine orifice nozzle chamber may generate a high energy by applying a high pressure as the diameter is small, but is not limited because the throughput per minute may be reduced, but it is preferable to use, for example, a diameter of 60 to 250 μm. . The temperature of the fine orifice nozzle chamber is preferably 20 to 80 ° C. in order not to affect the physical properties of the iron hydroxide solution, but is not necessarily limited thereto.

As the iron hydroxide solution passes through the micro-orifice nozzle chamber, high energy is generated by shear and cavitation to produce OH radicals and H ₂ O ₂ due to dissociation of water molecules, thereby producing the iron hydroxide solution as monodisperse iron oxide nanoparticles. . In addition, the micro-orifice nozzle chamber that generates high energy may act as an autoclave and thus affect nucleation and crystal growth.

Most of the methods for preparing nanoparticles are restricted by various conditions for the equipment because they react under complex process conditions at a high temperature. However, the method for preparing monodisperse iron oxide nanoparticles according to the present invention passes through an ultra-high pressure homogenizer at room temperature to produce monodisperse iron oxide. Nanoparticles can be synthesized, productivity is expected to increase as the process time is shortened, there is an advantage that the manufacturing equipment is simplified.

The radical reaction of water molecules according to the ultrahigh pressure homogenizer of the present invention may be represented by the following Scheme 1, but is not necessarily limited thereto.

Scheme 1

H ₂ O → H + OH

H + H · → H ₂

OH + OH-> H ₂ O ₂

In Scheme 1, the OH radicals generated by dissociation of water molecules by an ultrahigh pressure homogenizer and their combinations produce H ₂ O ₂ as an oxidant. Therefore, monodisperse iron oxide can be obtained from an aqueous iron hydroxide solution without adding an additional oxidizing agent and hydrothermal synthesis process.

Preparation of iron oxide nanoparticles by the ultrahigh pressure homogenizer of the present invention can be represented by the following scheme 2, but is not necessarily limited thereto.

Scheme 2

3Fe (OH) ₂ + H ₂ O ₂ → Fe ₃ O ₄ + 4H ₂ O

The monodisperse iron oxide is Fe ₂ ⁺ and Fe ^{3 +} is present as a mixed oxide of FeO + Fe ₂ O ₃ . Therefore, Fe ²⁺ is oxidized to both prevents the oxidation to Fe ³⁺ exist with the Fe ²⁺ and Fe ³⁺ - the pressure of the ultra-high pressure homogenizer to adjust the reducing atmosphere 500 ~ 2,000 bar, number of passes 1 to 20 It is preferred to be ash.

In addition, the number of passes may be repeated several times the transfer process from the heat exchanger to the high-pressure pump to produce the iron oxide nanoparticles, preferably by repeating the transfer process by the recirculation transfer pipe 1 to 20 times, iron oxide It may be prepared from monodisperse iron oxide nanoparticles, but is not necessarily limited thereto.

Step (b) is a step of washing and drying the precipitate of step (a). The washing is preferably to use distilled water, methanol and ethanol, but is not limited to any solution that can be easily removed after washing.

The drying is preferably dried for 3 to 10 hours at 50 ~ 100 ℃ to remove the moisture of the sample.

The monodisperse iron oxide nanoparticles of the present invention may have a spherical shape, and may produce superparamagnetic iron oxide nanoparticles having a particle size of 10 to 30 nm.

The monodisperse iron oxide nanoparticles according to the present invention have a uniform particle size distribution, high crystallinity using an ultrahigh pressure homogenizer, and easily control the size and physical properties of the nanoparticles produced by controlling the pressure and the number of passes of the ultrahigh pressure homogenizer. It is characterized by being adjustable.

Since the present invention does not use toxic surfactants or other dispersants, no iron oxide nanoparticle separation process is required, and instead of performing hydrothermal synthesis reaction at high temperature by adding an oxidizing agent, a radical reaction by an ultrahigh pressure homogenizer is used. Iron oxide nanoparticles can be produced in a simplified, shorter process time and environmentally friendly.

Since monodisperse iron oxide nanoparticles of the present invention exhibit a uniform particle size distribution and high crystallinity, applications of iron oxide nanoparticles in magnetic sensors, magneto-optical devices, magnetic ink, heavy metal wastewater treatment, MRI contrast agents, drug delivery systems, and thermotherapy It can be usefully used in the field.

Figure 1 shows a schematic diagram of the ultra-high pressure homogenizer used in the present invention.

Figure 2 shows the interior of the micro orifice nozzle chamber of the ultrahigh pressure homogenizer of the present invention.

3 is a flowchart illustrating a process of manufacturing iron oxide nanoparticles according to the present invention.

Figure 4 is a graph showing the results of analyzing the iron oxide nanoparticles prepared according to Examples 1 to 9 and Comparative Example 1 according to the present invention with a powder X-ray diffraction analyzer.

5 is a graph showing the size of the iron oxide particles calculated by the Scherrer equation from powder X-ray diffraction analysis of the iron oxide nanoparticles prepared according to Examples 1 to 9 and Comparative Example 1 according to the present invention.

6 is a transmission electron micrograph of the iron oxide nanoparticles prepared in Examples 1, 4, 7 and Comparative Example 1 according to the present invention.

7 is a transmission electron micrograph of the iron oxide nanoparticles prepared in Examples 7, 8, 9 and Comparative Example 1 according to the present invention.

8 is a transmission electron micrograph of the iron oxide nanoparticles prepared in Example 9 and Comparative Example 2 according to the present invention.

9 is a graph showing the magnetic properties of the iron oxide nanoparticles prepared in Examples 1, 4, 7, 8, 9 and Comparative Examples 1, 2 according to the present invention.

Hereinafter, the present invention will be described in more detail with reference to one example, but the present invention is not limited to the following examples.

Example 1

2.01 g of ferrous chloride (Junsei) was added to 100 ml of an aqueous solution to prepare a 0.1 M ferric chloride solution. 100 ml of 0.1 M ferrous chloride solution prepared above was added 0.85 M sodium hydroxide solution prepared by dissolving 1.02 g of sodium hydroxide (Samjeon Pure Chemical Co., Ltd.) in 30 ml distilled water, and mixed at room temperature for 5 minutes to prepare a green ferrous hydroxide suspension. . The ferrous hydroxide suspension was passed once through an ultrahigh pressure homogenizer (ILSIN autoclave, NH-300) at a pressure of 500 bar to obtain a black precipitate. The precipitate was washed with residual ions using distilled water and ethanol, and then dried at 80 ° C. for 6 hours to obtain iron oxide nanoparticles. The results of measuring the physical properties by the above method are shown in Table 1, FIGS. 4 to 6 and 9.

Example 2

Iron oxide nanoparticles were prepared in the same manner as in Example 1, except that the ferrous hydroxide suspension was passed through the ultra-high pressure homogenizer three times in Example 1, and the results of measuring the physical properties by the above method are shown in Tables 1, 4, 5 and 9 is shown.

Example 3

Iron oxide nanoparticles were prepared in the same manner as in Example 1, except that the ferrous hydroxide suspension was passed through the ultra-high pressure homogenizer five times in Example 1, and the results of measuring the physical properties by the above method are shown in Tables 1, 4, 5 and 9 is shown.

Example 4

Iron oxide nanoparticles were prepared in the same manner as in Example 1 except that the pressure of 1,000 bar was applied in Example 1, and the results of measuring the physical properties by the above method are shown in Table 1, FIGS. 4 to 6, and FIG. 9. .

Example 5

The iron oxide nanoparticles were prepared in the same manner as in Example 1 except that the pressure of 1,000 bar was applied in Example 1, and the ferrous hydroxide suspension was passed through an ultra-high pressure homogenizer three times. 1, 4, 5 and 9 are shown.

Example 6

Iron oxide nanoparticles were prepared in the same manner as in Example 1, except that the pressure of 1,000 bar was added in Example 1 and the ferrous hydroxide suspension was passed through the ultra-high pressure homogenizer five times. 1, 4, 5 and 9 are shown.

Example 7

Iron oxide nanoparticles were prepared in the same manner as in Example 1 except that the pressure of 1,500 bar was applied in Example 1, and the results of measuring the physical properties by the above method are shown in Tables 1, 4 to 7, and FIG. 9.

Example 8

Iron oxide nanoparticles were prepared in the same manner as in Example 1 except that the pressure of 1,500 bar was applied in Example 1 and the ferrous hydroxide suspension was passed through an ultrahigh pressure homogenizer three times. 1, 4, 5, 7 and 9 are shown.

Example 9

Iron oxide nanoparticles were prepared in the same manner as in Example 1 except that the pressure of 1,500 bar was added in Example 1 and the ferrous hydroxide suspension was passed through the ultra-high pressure homogenizer five times. 1, 4, 5 and 7 to 9 are shown.

Comparative Example 1

2.01 g of ferrous chloride (Junsei) was added to 100 ml of an aqueous solution to prepare a 0.1 M ferric chloride solution. 0.85 M sodium hydroxide solution prepared by dissolving 1.02 g of sodium hydroxide (Samjeon Pure Chemical Co., Ltd.) in 30 ml of distilled water was added to 100 ml of the 0.1 M ferric chloride aqueous solution prepared above, and then uniformly stirred at room temperature for 1 hour to obtain a precipitate. The precipitate was washed with residual ions using distilled water and ethanol, and then dried at 80 ° C. for 6 hours to obtain iron oxide nanoparticles. The results of measuring the physical properties by the above method are shown in Table 1, FIGS. 4 to 7 and FIG. 9.

Comparative Example 2

2.01 g of ferrous chloride (Junsei) was added to 100 ml of an aqueous solution to prepare a 0.1 M ferric chloride solution. To 100 ml of the 0.1 M ferric chloride solution prepared above, 0.82 M sodium hydroxide solution prepared by dissolving 1.02 g of sodium hydroxide (Samjeon Pure Chemical Co., Ltd.) in 30 ml distilled water was added and subjected to ultrasonic irradiation for 1 hour at 250 W at room temperature. To obtain a precipitate. The precipitate was washed with residual ions using distilled water and ethanol, and then dried at 80 ° C. for 6 hours to obtain iron oxide nanoparticles. The results of measuring the physical properties by the above method are shown in Table 1, FIG. 8 and FIG. 9.

Comparative Example 3

2.01 g of ferrous chloride (Junsei) was added to 100 ml of an aqueous solution to prepare a 0.1 M ferric chloride solution. To 100 ml of the 0.1 M ferrous chloride solution prepared above was added 0.85 M sodium hydroxide solution prepared by dissolving 1.02 g of sodium hydroxide (Samjeon Pure Chemical Co., Ltd.) in 30 ml distilled water, followed by stirring at room temperature for 30 minutes to prepare a ferric hydroxide suspension. . The ferrous hydroxide aqueous solution was irradiated with an irradiation dose of 300 kGy at a current of 1.0 MeV electron beam energy of 3.0 mA to obtain a precipitate. The precipitate was washed with residual ions by the addition of distilled water and ethanol, and dried at 60 ℃ for 6 hours to obtain iron oxide nanoparticles. Table 1 shows the results of measuring the physical properties by the above method.

TABLE 1

Crystal Structure Analysis of Iron Oxide Nanoparticles

In order to determine the crystallinity of the iron oxide nanoparticles prepared by the production method of the present invention using a powder X-ray diffraction analyzer (Rigaku, SmartLab) to analyze the crystallinity and the results are shown in FIG.

As shown in Figure 4, the particles produced in the above example was found to be iron oxide (Fe ₃ O ₄ ), Comparative Example 1 was not mixed with the iron oxide and FeOOH was not passed through the ultra-high pressure homogenizer. From this, it was confirmed that the iron oxide prepared using the ultrahigh pressure homogenizer was synthesized with pure iron oxide having high crystallinity and no impurities.

In addition, from the powder X-ray diffraction analysis, the average particle size of the iron oxide nanoparticles prepared using the Scherrer formula was calculated. The average particle size is shown in Figure 5, it was confirmed that the size of the particles can be adjusted according to the pressure and the number of passes of the ultra-high pressure homogenizer.

In FIG. 5, in the case of Example 9, although the particles were passed five times at 1,500 bar, the ultra-high pressure homogenizer, the particle size was confirmed to be larger than that of three passes at 1500 bar. This seems to be the phenomenon of crystal growth speeding up from five passes. Particle size depends on nucleation time and crystal growth time. The shorter the nucleation time and the longer the crystal growth time, the smaller the particle size is. Therefore, the particle size is increased again because the crystal growth is accelerated from more than 1500 bar three passes.

Analysis of Size and Morphology of Iron Oxide Nanoparticles

In order to determine the size and shape of the iron oxide nanoparticles prepared by the production method of the present invention was analyzed by transmission electron microscope (TEM, FEI, TecnaiG ² F30 S-Twin), the results are shown in Figures 6, 7 and 8. .

Grid used a 3 mm diameter copper grid coated with carbon.

As shown in Figure 6 and 7, the shape of the iron oxide nanoparticles prepared in Examples 1, 4, 7, 8 and 9 according to the present invention was shown as a spherical shape, the average size of the iron oxide nanoparticles are 24, It confirmed that it was 22, 20, 17, 22 nm. However, the particles prepared in Comparative Example 1 were found not to be a single phase such as spherical iron oxide and rod-shaped FeOOH, and the size distribution was also observed to be nonuniform.

As shown in Figure 8, it was confirmed that the iron oxide particles prepared by the ultrasonic irradiation of Comparative Example 2 also appeared with the bar-shaped FeOOH.

6, 7 and 8, the iron oxide produced according to the embodiment according to the present invention has a spherical shape, the iron oxide of the comparative example prepared by a simple stirring and ultrasonic irradiation while the iron oxide single phase FeOOH are present together and have been shown to have non-uniform particle size distribution. In addition, it was confirmed that the iron oxides synthesized through the examples were made of particles of 25 nm or less.

Magnetic Characterization of Monodisperse Iron Oxide Nanoparticles

In order to determine the magnetic properties of the iron oxide nanoparticles prepared by the method of the present invention, the magnetic properties were analyzed by a Vibrating Sample Magnetometer at room temperature, and are shown in FIG. 9 and Table 1.

In Examples 7 and 8, it was confirmed that the coercive force and the residual magnetization value were 0 to have superparamagnetic characteristics. In addition, the magnetization value measured at 10 KOe is much smaller than 92 emu / g, which is the saturation magnetization value for the lumped sample. This reduction in magnetization at nm size was found to be due to spin tilt due to the incomplete crystallographic structure and surface effects that occur as the particle size becomes smaller.

[Description of the code]

10: sample inlet

11: pressure pump

12: pressure gauge

13: heat exchanger

14 outlet

15: recycling transfer pipe

20: fine orifice nozzle chamber

21: Orifice

Claims

a) preparing an iron hydroxide solution by mixing the iron oxide precursor, distilled water and a precipitant solution, and then passing the ultra-high pressure homogenizer at a pressure of 500 to 2,000 bar at room temperature to obtain a precipitate, and

b) washing and drying the precipitate of step a),

Method for producing monodisperse iron oxide nanoparticles using an ultrahigh pressure homogenizer comprising a.
The method of claim 1,

The iron hydroxide solution is a method of producing mono-dispersed iron oxide nanoparticles using an ultrahigh pressure homogenizer which is prepared by dissolving the iron oxide precursor in distilled water to prepare a precursor aqueous solution and then adding a precipitant solution.
The method of claim 2,

The iron oxide precursor is any one selected from ferric chloride (FeCl 2 ), ferrous sulfate (FeSO 4 ) or iron acetate (Fe (CH 3 COO) 2 ) method for producing mono-dispersed iron oxide nanoparticles using an ultrahigh pressure homogenizer.
The method of claim 2,

The precipitant solution is any one or two or more selected from the group of ammonia water, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate and tetramethylammonium.
The method of claim 2,

The precursor aqueous solution is a method for producing mono-dispersed iron oxide nanoparticles using an ultrahigh pressure homogenizer having a concentration of 0.01 to 5 mol.
The method of claim 1,

The micro-orifice nozzle chamber included in the ultra-high pressure homogenizer is a method for producing mono-dispersed iron oxide nanoparticles using an ultra-high pressure homogenizer having a diameter of 60 ~ 250 ㎛.
The method of claim 6,

The fine orifice nozzle chamber temperature is 20 ~ 80 ℃ method of producing monodisperse iron oxide nanoparticles using an ultrahigh pressure homogenizer.
The method of claim 1,

Method for producing mono-dispersed iron oxide nanoparticles using an ultra-high pressure homogenizer that is passed through the precipitate obtained in step a) to the ultra-high pressure homogenizer 1 to 20 times.