WO2015180697A1 - Gel with silver nanoparticles, medical use and method for the production thereof - Google Patents
Gel with silver nanoparticles, medical use and method for the production thereof Download PDFInfo
- Publication number
- WO2015180697A1 WO2015180697A1 PCT/CR2014/000003 CR2014000003W WO2015180697A1 WO 2015180697 A1 WO2015180697 A1 WO 2015180697A1 CR 2014000003 W CR2014000003 W CR 2014000003W WO 2015180697 A1 WO2015180697 A1 WO 2015180697A1
- Authority
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- WIPO (PCT)
- Prior art keywords
- water
- silver
- composition
- silver nanoparticles
- nanoparticles
- Prior art date
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- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 9
- 230000004888 barrier function Effects 0.000 claims abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 6
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 206010040880 Skin irritation Diseases 0.000 claims abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims abstract description 5
- 230000036556 skin irritation Effects 0.000 claims abstract description 5
- 231100000475 skin irritation Toxicity 0.000 claims abstract description 5
- 206010052428 Wound Diseases 0.000 claims abstract description 4
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
- 229910052709 silver Inorganic materials 0.000 claims description 21
- 239000004332 silver Substances 0.000 claims description 21
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 20
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 12
- 239000002105 nanoparticle Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 230000001681 protective effect Effects 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- 238000010291 electrical method Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000001879 gelation Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 229910017604 nitric acid Inorganic materials 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 1
- 206010006797 Burns first degree Diseases 0.000 abstract 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 7
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 3
- 206010040872 skin infection Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010021531 Impetigo Diseases 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 208000035484 Cellulite Diseases 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010049752 Peau d'orange Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 230000036232 cellulite Effects 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940126703 systemic medication Drugs 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/08—Homopolymers or copolymers of acrylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
Definitions
- the present invention relates in general to a medical device consisting of a gel with silver nanoparticles. More particularly, the present invention relates to a treatment with antibacterial function to cure burns, scoriations and minor skin damage as well as the treatment and prevention of infections.
- Antibiotics are commonly used for the treatment of skin infections including impetigo, cellulite, and oral and topical antibiotics excoriation in the area of infected skin.
- topical antibiotics are advantageous in the treatment of infections located in the skin.
- Bacterial skin pathogens are effective because they are able to penetrate the epidermis. Some of these common pathogens include: S. aureus, S. pyogenes and S. epidermidis.
- topical antimicrobial agents are aimed at attacking bacteria, viruses and fungi. They have been used with significant success in the prevention and treatment of a number of infections, including impetigo, candidiasis, athlete's foot, acne and infections resulting from burns and surgical wounds.
- silver is advantageous as a topical antibiotic when the action is located in a certain place at concentrations of 5 ppm or less. Silver in a form of nanoparticles has proven to be non-toxic with irritation or lackof sensitization.
- this invention consists in the use of the properties of the gel as a protective barrier against infections, thereby maximizing the properties of silver to cure recurrent skin diseases.
- This invention is a gel made of silver nanoparticles, very effective for skin wounds, as well as minor discontinuities of the skin such as scratches, cuts, burns and insect bites.
- the product is born in nanotechnology and is especially effective due to its particle size that will allow better results than the other gels based on silver ions that are marketed worldwide.
- Ionic silver near a virus, fungi, bacteria or any other unicellular organism neutralizes the enzymes they use to metabolize oxygen, while altering the permeability of the membrane of the unicellular organism. In a few minutes these organisms are effectively suffocated. It is also known that ionic silver does not act on host cells, as enzymes are radically different from those of unicellular organisms.
- the present invention consists of a gel composition of silver nanoparticles in water, which has a 97% concentration of distilled or deionized water, 2.9% of the alkyl polyacrylate polymer (Ultrez 21), 0.1% of lon sodium (sodium hydroxide or NaOH) and 5ppm of silver nanoparticles (Ag).
- the alkyl acrylate polymer (Ultrez 21) is a hydrophobically modified crosslinked polymer.
- the silver nanoparticles (Ag) are given in low concentrations suspended in distilled or deionized water and produced by electrical methods from silver electrodes. They have an atomic mass of 107,868 g / mol, their melting point is 960.5 ° C, their boiling point is 2000 ° C and the density at 15 ° C is 10.49 g / mL.
- This gel is easy to react with dilute nitric acid and hot sulfuric acid; and is not sensitive to light in the metallic form. Additionally, sodium hydroxide or anhydrous caustic soda is used to neutralize acids.
- the gelation methodology does not produce residues that generate bacterial proliferation, which increases the effectiveness of the product.
- the invention is also a process for obtaining the above gel composition.
- This process takes several steps that start with placing 100 Liters of distilled or deionized water in a stainless steel container and a polyethylene hose is inserted, connected to a water pump.
- the water pump drives the water towards the silver nanoparticle generator, which is connected to a voltage source of 110 Volts.
- the generator has one to control the amount of water entering the electrodes and another to regulate the amount of water leaving the system.
- a second water pump connected to a 110-120V outlet the water containing the silver nanoparticles in the system is recirculated for one minute, to increase the concentrations of the silver particles and ensure that the final product contain the concentrations of silver nanoparticles required.
- the controlled size of the nanoparticles is done through filtration.
- the silver nanoparticle generator uses a 110-115V voltage source and consists of a current controller that produces the silver nanoparticles in line; two silver electrodes placed in a compartment and a cellulose filter that restricts the passage of large silver particles, allowing only nanoparticles to pass between 8 and 100 nm.
- This invention acts as an antibacterial protective barrier promoting the cleaning of wounds, minor cuts, grade 1 burns and skin irritations.
- PROTECTOR for which the product is used as a Gel for skin irritations, it contains nanoparticles of water-based silver that inhibits bacterial growth. It is an antibacterial protective barrier, for use on risky skin. It can be used for use in skin irritations, leaves no residue, has no smell or color. In the CURATIONS version, it is a gel for minor wounds such as scoriations, minor cuts, containing water-based silver nanoparticles that inhibit bacterial growth.
- the present invention is a breakthrough in surface chemical nanotechnology. A protective barrier for use in minor cuts, scoriations and injuries that affect the continuity of the skin.
- This gel works for grade 1 burns, contains water-based silver nanoparticles that inhibits bacterial growth and functions as a protective barrier for use in grade one burns.
- the availability of this invention as an antibiotic that can be applied topically to primary and secondary skin surface infections, is capable of producing results equivalent to those that must be generated with the use of systemic medication, without the risk of side effects , so it represents the ideal antibacterial therapy.
- the product has proven to be more effective than the oral cephalexin cure and has been proven by the clinical improvement of skin infections and the elimination of initially isolated microorganisms.
- Applying a gel stability and storage test method to assess its stability in real time and to determine the storage time of the silver product it was determined that the concentration of the silver nanoparticles in the product varied from 0.5 to 1 ppm.
- the study was carried out by Laboratorios Praeventio for LAASAT SA and was supervised by the Quality Control Laboratory Section. The study showed that the product has a stability for more than 5 years.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a gel composition of silver nanoparticles in water for medical use, wherein 95% is distilled or deionised water, 2.9% is a polyacrylate alkyl polymer (Ultrez 21), 0.1% is sodium ion and there is a 5 ppm concentration of silver nanoparticles. The invention also relates to the method for producing said composition. The resulting gel acts as an antibacterial protection barrier facilitating the cleaning of wounds, minor cuts, first degree burns and skin irritations.
Description
"GEL CON NANOPARTÍCULAS DE PLATA USO MÉDICO Y PROCESO PARA SU OBTENCIÓ "GEL WITH SILVER NANOPARTICLES MEDICAL USE AND PROCESS FOR OBTAINED
CAMPO DE LA INVENCIÓN FIELD OF THE INVENTION
La presente invención se relaciona en general con un dispositivo médico consistente en un gel con nanopartículas de plata. Más particularmente, la presente invención se relaciona con un tratamiento con función antibacteriano para curar quemaduras, escoriaciones y daños menores en la piel así como el tratamiento y prevención de infecciones. The present invention relates in general to a medical device consisting of a gel with silver nanoparticles. More particularly, the present invention relates to a treatment with antibacterial function to cure burns, scoriations and minor skin damage as well as the treatment and prevention of infections.
ANTECEDENTES DE LA INVENCIÓN BACKGROUND OF THE INVENTION
Las infecciones primarias y secundarias de la piel son una causa frecuente de morbilidad y motivo frecuente de consulta de un dermatólogo y médico general. Los antibióticos se utilizan comúnmente para el tratamiento de infecciones de la piel incluyendo impétigo, celulitis, y antibióticos orales y tópicos excoriación en la zona de la piel infectada. Primary and secondary skin infections are a frequent cause of morbidity and a frequent reason for consulting a dermatologist and general practitioner. Antibiotics are commonly used for the treatment of skin infections including impetigo, cellulite, and oral and topical antibiotics excoriation in the area of infected skin.
De mayor preocupación en el uso de estos antibióticos son reacciones de sensibilización que pueden producirse. Of greater concern in the use of these antibiotics are sensitization reactions that may occur.
Un abordaje sistémico con antibióticos de amplio espectro puede ser un problema debido a la resistencia a los antibióticos. Por consiguiente, los antibióticos tópicos son ventajosos en el tratamiento de infecciones localizadas en la piel.A systemic approach with broad-spectrum antibiotics can be a problem due to antibiotic resistance. Therefore, topical antibiotics are advantageous in the treatment of infections located in the skin.
Los patógenos bacterianos de la piel son eficaces ya que son capaces de penetrar en la epidermis. Algunos de estos patógenos comunes incluyen: S. aureus, S. pyogenes y S. epidermidis. Bacterial skin pathogens are effective because they are able to penetrate the epidermis. Some of these common pathogens include: S. aureus, S. pyogenes and S. epidermidis.
En general, los agentes antimicrobianos tópicos están dirigidos a atacar las bacterias, virus y hongos. Se han utilizado con un importante éxito en la prevención y el tratamiento de un número de infecciones, incluyendo impétigo, candidiasis, pie de atleta, acné y las infecciones resultantes de quemaduras y heridas quirúrgicas. In general, topical antimicrobial agents are aimed at attacking bacteria, viruses and fungi. They have been used with significant success in the prevention and treatment of a number of infections, including impetigo, candidiasis, athlete's foot, acne and infections resulting from burns and surgical wounds.
Las propiedades antimicrobianas de la plata han sido ampliamente reconocidas y se ha demostrado que es eficaz contra la mayoría de los estafilococos, incluyendo MRSA, y S. pyogenes. La plata es ventajosa como un antibiótico tópico cuando la acción se localiza en determinado lugar en concentraciones de 5 ppm o menos. La plata en una forma de nanopartículas ha demostrado ser no tóxica con irritación o sensibilización lackof. The antimicrobial properties of silver have been widely recognized and have been shown to be effective against most staphylococci, including MRSA, and S. pyogenes. Silver is advantageous as a topical antibiotic when the action is located in a certain place at concentrations of 5 ppm or less. Silver in a form of nanoparticles has proven to be non-toxic with irritation or lackof sensitization.
Precisamente, esta invención consiste en la utilización de las propiedades del gel como una barrera protectora contra infecciones, maximizando con ello las propiedades de la plata para curar enfermedades recurrentes de la piel.
DESCRIPCIÓN DETALLADA DE LA INVENCIÓN Precisely, this invention consists in the use of the properties of the gel as a protective barrier against infections, thereby maximizing the properties of silver to cure recurrent skin diseases. DETAILED DESCRIPTION OF THE INVENTION
Esta invención es un gel hecho a base de nanopartículas de plata, muy eficaz para heridas en la piel, además de discontinuidades menores de la piel tales como rasguños, cortes, quemaduras y picaduras de insectos. This invention is a gel made of silver nanoparticles, very effective for skin wounds, as well as minor discontinuities of the skin such as scratches, cuts, burns and insect bites.
El producto nace en la nanotecnología y es especialmente eficaz debido a su tamaño de partícula que permitirá mejores resultados que los otros geles a base de iones de plata que se comercializan en todo el mundo. La plata iónica, cerca de un virus, hongos, bacterias o cualquier otro organismo unicelular neutraliza las enzimas que utilizan para metabolizar el oxígeno, al mismo tiempo que alteran la permeabilidad de la membrana del organismo unicelular. En pocos minutos estos organismos son efectivamente asfixiados. También se sabe que la plata iónica no actúa sobre las células del huésped, como las enzimas son radicalmente diferentes a las de los organismos unicelulares. The product is born in nanotechnology and is especially effective due to its particle size that will allow better results than the other gels based on silver ions that are marketed worldwide. Ionic silver, near a virus, fungi, bacteria or any other unicellular organism neutralizes the enzymes they use to metabolize oxygen, while altering the permeability of the membrane of the unicellular organism. In a few minutes these organisms are effectively suffocated. It is also known that ionic silver does not act on host cells, as enzymes are radically different from those of unicellular organisms.
La presente invención consiste en una composición en gel de nanopartículas de plata en agua, que presenta una concentración del 97% de agua destilada o desionizada, 2,9% del polímero de poliacrilato de alquilo (Ultrez 21), 0,1% de lón sódico (hidróxido de sodio o NaOH) y 5ppm de nanopartículas de plata (Ag). The present invention consists of a gel composition of silver nanoparticles in water, which has a 97% concentration of distilled or deionized water, 2.9% of the alkyl polyacrylate polymer (Ultrez 21), 0.1% of lon sodium (sodium hydroxide or NaOH) and 5ppm of silver nanoparticles (Ag).
El polímero acrilato de alquilo (Ultrez 21) es un polímero reticulado hydrofóbicamente modificado. The alkyl acrylate polymer (Ultrez 21) is a hydrophobically modified crosslinked polymer.
En esta composición las nanopartículas de plata (Ag) se dan en bajas concentraciones suspendidas en agua destilada o desionizada y producida por métodos eléctricos a partir de electrodos de plata. Poseen una masa atómica de 107,868 g/mol, su punto de fusión es 960,5 °Ce, su punto de ebullición es 2000 °C y la densidad a 15 °C es de 10,49 g/mL. In this composition the silver nanoparticles (Ag) are given in low concentrations suspended in distilled or deionized water and produced by electrical methods from silver electrodes. They have an atomic mass of 107,868 g / mol, their melting point is 960.5 ° C, their boiling point is 2000 ° C and the density at 15 ° C is 10.49 g / mL.
Este gel es de fácil reacción con ácido nítrico diluido y ácido sulfúrico caliente; y no es sensible a la luz en la forma metálica. Adicionalmente, el Hidróxido de sodio o soda caústica anhidra, se utiliza para neutralizar los ácidos. This gel is easy to react with dilute nitric acid and hot sulfuric acid; and is not sensitive to light in the metallic form. Additionally, sodium hydroxide or anhydrous caustic soda is used to neutralize acids.
La metodología de gelificación no produce residuos que generen proliferación bacteriana lo que permite aumentar la eficacia del producto. The gelation methodology does not produce residues that generate bacterial proliferation, which increases the effectiveness of the product.
La invención, se trata también de un proceso para obtener la composición de gel anterior. Este proceso toma diversos pasos que inician con colocar 100 Litros de agua destilada o desionizada en un recipiente de acero inoxidable y se le introduce una manguera de polietileno, conectada a una bomba de agua. La bomba de agua impulsa el agua hacia el generador de nanopartículas de plata, el cual está conectado a una fuente de voltaje de 110 Voltios. El generador tiene una para controlar la cantidad de agua que ingresa a los electrodos y otra para regular la cantidad de agua que sale del sistema.
En una segunda bomba de agua conectada a un toma corriente de 110-120 V, se hace recircular por un minuto el agua que contiene las nanopartículas de plata en el sistema, para aumentar las concentraciones de las partículas de plata y asegurar que el producto final contenga las concentraciones de nanopartículas de plata requeridas. El tamaño controlado de las nanopartículas se hace a través de filtración. The invention is also a process for obtaining the above gel composition. This process takes several steps that start with placing 100 Liters of distilled or deionized water in a stainless steel container and a polyethylene hose is inserted, connected to a water pump. The water pump drives the water towards the silver nanoparticle generator, which is connected to a voltage source of 110 Volts. The generator has one to control the amount of water entering the electrodes and another to regulate the amount of water leaving the system. In a second water pump connected to a 110-120V outlet, the water containing the silver nanoparticles in the system is recirculated for one minute, to increase the concentrations of the silver particles and ensure that the final product contain the concentrations of silver nanoparticles required. The controlled size of the nanoparticles is done through filtration.
En los 100 L de agua con nanopartículas de plata resultantes, contenidos en un recipiente de acero inoxidable grado sanitario, se disuelven 529,4 g del polímero de poliacrilato de alquilo (Ultrez 21) y se agita con una propela de acero inoxidable, conectada a un motor de 1/8 HP. In the 100 L of water with resulting silver nanoparticles, contained in a sanitary grade stainless steel container, 529.4 g of the alkyl polyacrylate polymer (Ultrez 21) is dissolved and stirred with a stainless steel propeller, connected to a 1/8 HP engine.
Cuando se ha disuelto el polímero acrilato de alquilo (Ultrez 21), se agregan lentamente, bajo agitación, 2,65 L de una disolución de NaOH 1,5 M. Se agita durante 5 minutos hasta que se homogenice el ge!, procurando que el pH final oscile entre 6,0 y 7,0. Si el pH está bajo 6,0, se agrega gota a gota una disolución de NaOH 1,5 M, hasta que el pH quede en el rango indicado. When the alkyl acrylate polymer (Ultrez 21) has dissolved, 2.65 L of a 1.5 M NaOH solution are slowly added under stirring. It is stirred for 5 minutes until the ge! Is homogenized, ensuring that The final pH ranges between 6.0 and 7.0. If the pH is below 6.0, a solution of 1.5 M NaOH is added dropwise, until the pH falls within the indicated range.
El generador de nanopartículas de plata utiliza una fuente de voltaje de 110-115 V y consta de un controlador de la corriente que produce las nanopartículas de plata en línea; dos electrodos de plata colocados en un compartimiento y un filtro de celulosa que restringe el paso de partículas grandes de plata, dejando pasar solo nanopartículas entre 8 y 100 nm. The silver nanoparticle generator uses a 110-115V voltage source and consists of a current controller that produces the silver nanoparticles in line; two silver electrodes placed in a compartment and a cellulose filter that restricts the passage of large silver particles, allowing only nanoparticles to pass between 8 and 100 nm.
Esta invención actúa como una barrera antibacterial de protección promoviendo la limpieza de heridas, cortaduras menores, quemaduras grado 1 e irritaciones de la piel. This invention acts as an antibacterial protective barrier promoting the cleaning of wounds, minor cuts, grade 1 burns and skin irritations.
Dentro de los usos a reivindicar en el producto está el de PROTECTOR para lo cual el producto se utiliza como un Gel para irritaciones de la piel, contiene nanopartículas de plata en base acuosa que inhibe el crecimiento bacteriano. Se trata de una barrera protectora antibacterial, para uso en piel con riesgo. Puede ser utilizada para uso en irritaciones de la piel, no deja residuos, no tiene olor ni color. En la versión para CURACIONES, es un gel para heridas menores como escoriaciones, cortadas menores, contiene nanopartículas de plata en base acuosa que inhibe el crecimiento bacteriano. La presente invención se trata de un gran avance en Nanotecnología química de superficie. Una barrera protectora para uso en cortadas menores, escoriaciones y lesiones que afectan la continuidad de la piel. Among the uses to be claimed in the product is that of PROTECTOR for which the product is used as a Gel for skin irritations, it contains nanoparticles of water-based silver that inhibits bacterial growth. It is an antibacterial protective barrier, for use on risky skin. It can be used for use in skin irritations, leaves no residue, has no smell or color. In the CURATIONS version, it is a gel for minor wounds such as scoriations, minor cuts, containing water-based silver nanoparticles that inhibit bacterial growth. The present invention is a breakthrough in surface chemical nanotechnology. A protective barrier for use in minor cuts, scoriations and injuries that affect the continuity of the skin.
Este gel funciona para quemaduras grado 1, contiene nanopartículas de plata en base acuosa que inhibe el crecimiento bacteriano y funciona como una barrera protectora para uso en quemaduras grado uno. La disponibilidad de esta invención como antibiótico que puede aplicarse tópicamente a las infecciones primarias y secundarias de la superficie de la piel, es capaz de producir resultados equivalentes a los que han de ser generado con el uso de medicación sistémica, sin el riesgo de efectos secundarios, por lo que representa la terapia ideal antibacteriana.
El producto ha demostrado ser más eficaz que la cura cefalexina oral y la ha probado la mejoría clínica de infecciones de la piel y en la eliminación de los microorganismos aislados inicialmente. Aplicándole un método de prueba de estabilidad y almacenamiento al gel para evaluar en tiempo real su estabilidad y para determinar el tiempo de almacenamiento del producto de plata, se determinó que la concentración de las nanopartículas de plata en el producto varió de 0,5 a 1 ppm. El estudio fue realizado por Laboratorios Praeventio para LAASAT SA y fue supervisado por la Sección de Laboratorio de Control de Calidad. El estudio demostró que el producto posee una estabilidad durante más de 5 años.
This gel works for grade 1 burns, contains water-based silver nanoparticles that inhibits bacterial growth and functions as a protective barrier for use in grade one burns. The availability of this invention as an antibiotic that can be applied topically to primary and secondary skin surface infections, is capable of producing results equivalent to those that must be generated with the use of systemic medication, without the risk of side effects , so it represents the ideal antibacterial therapy. The product has proven to be more effective than the oral cephalexin cure and has been proven by the clinical improvement of skin infections and the elimination of initially isolated microorganisms. Applying a gel stability and storage test method to assess its stability in real time and to determine the storage time of the silver product, it was determined that the concentration of the silver nanoparticles in the product varied from 0.5 to 1 ppm. The study was carried out by Laboratorios Praeventio for LAASAT SA and was supervised by the Quality Control Laboratory Section. The study showed that the product has a stability for more than 5 years.
BIBLIOGRAFÍA BIBLIOGRAPHY
Atiyeh, B. S., Costagliola, M., Hayek, S.N. and Dibo, SA (2007) Effect of silver on burn wound ¡nfection control and healing: review of the literature. Burn 33, 139-148. Ayala-Nunez, MD, Villegas, HHL, Turrent, LCI and Padilla, C. R. (2009) Silver nanoparticles toxicity and bactericidal effect against methicillin resistant Staphylococcus aureus: Nanoscale Does Matter. Nanobiotechnology 5, 2-9. Baker, C, Pradhan, A., Pakstis, L, Pochan, D.J. and Shah, S.I. (2005) Synthesis and antibacterial properties of silver nanoparticles. NanoSci J Nanotechnol 2, 244-249. Birla, SS, Tiwari, W, Gade, AK, Ingle, AP, Yadav, AP and Rai, M. K. (2009) Fabrication of silver nanoparticles by Phoma glomerata and its combined effect against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Lett Appl Microbiol 48, 173- 179. Castilian, JJ, Shafii, SM, Ko, F., Dónate, G., Wright, TE, Mannari, RJ, Payne, WG, Smith, DJ et al. (2007) Comparative evaluation of silver-containing antimicrobial dressings and drugs. Int Wound J 4, 14-22. Cristóbal Espinosa, LF, Martinez-Castanon, GA, Martinez-Martinez, RE, Loyola- Rodriguez, JP, Patino-Marin, N., Reyes-Macias, JF and Ruiz, F. (2009) Antibacterial effect of silver nanoparticles against Streptococcus mutans. Mater Lett 63, 2603-2606. Falagas, M. E., Grammatikos, A.P. and Michalopoulos, A. (2008) Potential of old- generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther 6, 593-600. Feng, QL, Wu, J., Chen, GQ, Cui, FZ, Kim, TN and Kim, J.O. (2000) Mechanistic study of the antibacterial effect of silver ions onEscherichia coli and Staphylococcus aureus. J Biomed Mater Res 52, 662-668. Humberto, H., Lara, V., Ayala-Nunez NV, Carmen, LD, Ixtepan, T. and Cristina, R.P. (2010) Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. World J Microbiol Biotechnol 26, 615-621.
Atiyeh, B. S., Costagliola, M., Hayek, S.N. and Dibo, SA (2007) Effect of silver on burn wound ¡nfection control and healing: review of the literature. Burn 33, 139-148. Ayala-Nunez, MD, Villegas, HHL, Turrent, LCI and Padilla, C. R. (2009) Silver nanoparticles toxicity and bactericidal effect against methicillin resistant Staphylococcus aureus: Nanoscale Does Matter. Nanobiotechnology 5, 2-9. Baker, C, Pradhan, A., Pakstis, L, Pochan, D.J. and Shah, S.I. (2005) Synthesis and antibacterial properties of silver nanoparticles. NanoSci J Nanotechnol 2, 244-249. Birla, SS, Tiwari, W, Gade, AK, Ingle, AP, Yadav, AP and Rai, M. K. (2009) Fabrication of silver nanoparticles by Phoma glomerata and its combined effect against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Lett Appl Microbiol 48, 173-179. Castilian, JJ, Shafii, SM, Ko, F., Donate, G., Wright, TE, Mannari, RJ, Payne, WG, Smith, DJ et al. (2007) Comparative evaluation of silver-containing antimicrobial dressings and drugs. Int Wound J 4, 14-22. Cristóbal Espinosa, LF, Martinez-Castanon, GA, Martinez-Martinez, RE, Loyola- Rodriguez, JP, Patino-Marin, N., Reyes-Macias, JF and Ruiz, F. (2009) Antibacterial effect of silver nanoparticles against Streptococcus mutans Mater Lett 63, 2603-2606. Falagas, M. E., Grammatikos, A.P. and Michalopoulos, A. (2008) Potential of old- generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther 6, 593-600. Feng, QL, Wu, J., Chen, GQ, Cui, FZ, Kim, TN and Kim, J.O. (2000) Mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res 52, 662-668. Humberto, H., Lara, V., Ayala-Nunez NV, Carmen, LD, Ixtepan, T. and Cristina, R.P. (2010) Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. World J Microbiol Biotechnol 26, 615-621.
Claims
REIVINDICACIONES
Una composición en gel de nanopartículas de plata en agua, que comprende: A gel composition of silver nanoparticles in water, comprising:
Una concentración del 97% de agua, A concentration of 97% water,
2,9% del polímero de poliacrilato de alquilo (Ultrez 21) 2.9% of the alkyl polyacrylate polymer (Ultrez 21)
0,1% de lón sódico (hidróxido de sodio o NaOH) y 0.1% sodium loon (sodium hydroxide or NaOH) and
5ppm de nanopartículas de plata (Ag). 5ppm of silver nanoparticles (Ag).
Una composición de la reivindicación 1, donde el polímero acrilato de alquilo (Ultrez 21) es un polímero reticulado hydrofóbicamente modificado. A composition of claim 1, wherein the alkyl acrylate polymer (Ultrez 21) is a hydrophobically modified crosslinked polymer.
Una composición de la reivindicación 1, donde el agua es destilada o desionizada. A composition of claim 1, wherein the water is distilled or deionized.
Una composición de la reivindicación 1, donde las nanopartículas de plata (Ag) poseen las siguientes características: A composition of claim 1, wherein the silver nanoparticles (Ag) possess the following characteristics:
Se dan en bajas concentraciones suspendidas en agua destilada o desionizada y producida por métodos eléctricos a partir de electrodos de plata; They occur in low concentrations suspended in distilled or deionized water and produced by electrical methods from silver electrodes;
Poseen una masa atómica de 107,868 g/mol; They have an atomic mass of 107,868 g / mol;
Su punto de fusión es 960,5 °Ce; Its melting point is 960.5 ° Ce;
Su punto de ebullición es 2000 °C; Its boiling point is 2000 ° C;
Su densidad a 15 °C es de 10,49 g/mL; Its density at 15 ° C is 10.49 g / mL;
Son de fácil reacción con ácido nítrico diluido y ácido sulfúrico caliente; y They are easy to react with dilute nitric acid and hot sulfuric acid; Y
No son sensibles a la luz en la forma metálica. They are not sensitive to light in the metallic form.
Una composición de la reivindicación 1, donde el Hidróxido de sodio o soda caústica anhidra, se utiliza para neutralizar los ácidos. A composition of claim 1, wherein the sodium hydroxide or anhydrous caustic soda, is used to neutralize the acids.
Una composición de la reivindicación 1, donde la metodología de gelificación no produce residuos que generen proliferación bacteriana. A composition of claim 1, wherein the gelation methodology does not produce residues that generate bacterial proliferation.
Un proceso para obtener la composición de la reivindicación 1, que consiste en los siguientes pasos: A process for obtaining the composition of claim 1, consisting of the following steps:
Se colocan 100 L de agua destilada o desionizada en un recipiente de acero inoxidable y se le introduce una manguera de polietileno, conectada a una bomba de agua; 100 L of distilled or deionized water are placed in a stainless steel container and a polyethylene hose is inserted, connected to a water pump;
La bomba de agua impulsa el agua hacia el generador de nanopartículas de plata, el cual está conectado a una fuente de voltaje de 110 Voltios; The water pump drives the water towards the silver nanoparticle generator, which is connected to a voltage source of 110 Volts;
El generador tiene una para controlar la cantidad de agua que ingresa a los electrodos y otra para regular la cantidad de agua que sale del sistema; The generator has one to control the amount of water entering the electrodes and another to regulate the amount of water leaving the system;
En una segunda bomba de agua conectada a un toma corriente de 110-120 V, se hace re-circular por un minuto el agua que contiene las nanopartículas de plata en el sistema, para aumentar las concentraciones de las partículas de plata y asegurar que el producto final contenga las concentraciones de nanopartículas de plata requeridas;
En los 100 L de agua con nanopartículas de plata resultantes, contenidos en un recipiente de acero inoxidable grado sanitario, se disuelven 529,4 g del polímero de poliacrilato de alquilo (Ultrez 21) y se agita con una propela de acero inoxidable, conectada a un motor de 1/8 HP; In a second water pump connected to a 110-120 V outlet, the water containing the silver nanoparticles in the system is re-circulated for one minute, to increase the concentrations of the silver particles and ensure that the final product contains the required concentrations of silver nanoparticles; In the 100 L of water with resulting silver nanoparticles, contained in a sanitary grade stainless steel container, 529.4 g of the alkyl polyacrylate polymer (Ultrez 21) is dissolved and stirred with a stainless steel propeller, connected to a 1/8 HP engine;
Cuando se ha disuelto el polímero acrilato de alquilo (Ultrez 21), se agregan lentamente, bajo agitación, 2,65 L de una disolución de NaOH 1,5 M. When the alkyl acrylate polymer (Ultrez 21) has dissolved, 2.65 L of a 1.5 M NaOH solution are slowly added under stirring.
Se agita durante 5 minutos hasta que se homogenice el gel, procurando que el pH final oscile entre 6,0 y 7,0; Stir for 5 minutes until the gel is homogenized, ensuring that the final pH ranges between 6.0 and 7.0;
Si el pH está bajo 6,0, se agrega gota a gota una disolución de NaOH 1,5 M, hasta que el pH quede en el rango indicado. If the pH is below 6.0, a solution of 1.5 M NaOH is added dropwise, until the pH falls within the indicated range.
8. Un proceso de la reivindicación 7, donde las medidas varían proporcionalmente en los porcentajes indicados en la composición de la reivindicación 1, conforme al volumen que se requiera de resultado. 8. A process of claim 7, wherein the measurements vary proportionally in the percentages indicated in the composition of claim 1, according to the volume required of the result.
9. Un proceso de la reivindicación 7, donde el Generador de nanopartículas de plata utiliza una fuente de voltaje de 110-115 V y consta de un controlador de la corriente que produce las nanopartículas de plata en línea; dos electrodos de plata colocados en un compartimiento y un filtro de celulosa que restringe el paso de partículas grandes de plata, dejando pasar solo nanopartículas entre 8 y 100 nm. 9. A process of claim 7, wherein the Silver nanoparticle generator uses a voltage source of 110-115 V and consists of a current controller that produces the silver nanoparticles in line; two silver electrodes placed in a compartment and a cellulose filter that restricts the passage of large silver particles, allowing only nanoparticles to pass between 8 and 100 nm.
10. Un proceso de la reivindicación 7, donde el tamaño controlado de las nanopartículas se hace a través de filtración. 10. A process of claim 7, wherein the controlled size of the nanoparticles is done through filtration.
11. Una composición de la reivindicación 1, que actúa como una barrera antibacterial de protección promoviendo la limpieza de heridas, cortaduras menores, quemaduras grado 1 e irritaciones de la piel.
11. A composition of claim 1, which acts as an antibacterial protective barrier promoting the cleaning of wounds, minor cuts, grade 1 burns and skin irritations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| PCT/CR2014/000003 WO2015180697A1 (en) | 2014-05-26 | 2014-05-26 | Gel with silver nanoparticles, medical use and method for the production thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| PCT/CR2014/000003 WO2015180697A1 (en) | 2014-05-26 | 2014-05-26 | Gel with silver nanoparticles, medical use and method for the production thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170191010A1 (en) * | 2016-01-06 | 2017-07-06 | Nanjing Inst Of Compreh Utilization Of Wild Plants | Bactericidal, Fungicidal and Anti-Allergenic Zanthoxylum Schinifolium Skin Care Soap and Method of Preparation |
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| WO2008080980A1 (en) * | 2006-12-29 | 2008-07-10 | Patrick Franke | Medicinal composition for treating animal skin comprising a wound healing agent and a deterrent |
| WO2010051918A2 (en) * | 2008-11-04 | 2010-05-14 | Pharmasol Gmbh | Compositions containing lipid micro- or nanoparticles for the enhancement of the dermal action of solid particles |
| WO2012174466A2 (en) * | 2011-06-17 | 2012-12-20 | Annuary Healthcare, Inc. | Nanoscale particle formulations and methods |
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| WO2008080980A1 (en) * | 2006-12-29 | 2008-07-10 | Patrick Franke | Medicinal composition for treating animal skin comprising a wound healing agent and a deterrent |
| WO2010051918A2 (en) * | 2008-11-04 | 2010-05-14 | Pharmasol Gmbh | Compositions containing lipid micro- or nanoparticles for the enhancement of the dermal action of solid particles |
| WO2012174466A2 (en) * | 2011-06-17 | 2012-12-20 | Annuary Healthcare, Inc. | Nanoscale particle formulations and methods |
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| US20170191010A1 (en) * | 2016-01-06 | 2017-07-06 | Nanjing Inst Of Compreh Utilization Of Wild Plants | Bactericidal, Fungicidal and Anti-Allergenic Zanthoxylum Schinifolium Skin Care Soap and Method of Preparation |
| US10640739B2 (en) * | 2016-01-06 | 2020-05-05 | Nanjing Inst Of Compreh Utilization Of Wild Plants | Bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap and method of preparation |
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