WO2015172683A1 - Injecteur sans aiguille à stockage d'énergie et actionné manuellement - Google Patents

Injecteur sans aiguille à stockage d'énergie et actionné manuellement Download PDF

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Publication number
WO2015172683A1
WO2015172683A1 PCT/CN2015/078574 CN2015078574W WO2015172683A1 WO 2015172683 A1 WO2015172683 A1 WO 2015172683A1 CN 2015078574 W CN2015078574 W CN 2015078574W WO 2015172683 A1 WO2015172683 A1 WO 2015172683A1
Authority
WO
WIPO (PCT)
Prior art keywords
impact member
human
cylinder
chamber
piston
Prior art date
Application number
PCT/CN2015/078574
Other languages
English (en)
Chinese (zh)
Inventor
孙万平
王明娣
王传洋
窦云霞
Original Assignee
苏州大学张家港工业技术研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 苏州大学张家港工业技术研究院 filed Critical 苏州大学张家港工业技术研究院
Publication of WO2015172683A1 publication Critical patent/WO2015172683A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Definitions

  • the present invention relates to a human-powered, energy-storing needle-free injector.
  • the needle-free injection technology is used for drug injection without the aid of a needle.
  • the liquid medicine directly enters the body tissue by means of ultra-fine, high-speed, straight-line high-pressure jet, which solves a series of problems caused by the needle injection into the body.
  • problems caused by the needle injection into the body Such as: pain, bleeding, infection, tissue damage, psychological pressure of patients, etc.; at the same time, the distribution of drugs without needle injection in the tissue is more diffuse, which is conducive to the absorption of drugs, long-term injection of skin is not easy to induration. Therefore, needle-free injection technology has broad application prospects, especially for children vaccination and diabetes patients.
  • the human-powered needle-free injector generally works by the principle of spring energy storage and instant firing.
  • the Chinese patent number is ZL201320568118.5
  • the patent name is the structure in the 'needle-free injector'
  • the advantage is the structure.
  • the simple operation and the injection operation are convenient; the main disadvantage is that the firing device of the syringe is separated from the device for resetting and storing the spring, and the resetting operation is extremely inconvenient, and is not suitable for the occasion requiring continuous rapid injection.
  • a human-powered energy-storing needle-free injector comprising a cylinder having a lumen, a front end cover fixed to the front end of the cylinder, and a needle-free ampoule assembly mounted on the front end cover,
  • An impact member that is movably disposed in the cylinder barrel in a front-rear direction, a closed chamber is disposed between the impact member and the rear portion of the cylinder barrel, and the needle-free injector further includes a chamber for the chamber a human-powered air supply device filled with a compressed gas, the needleless ampoule assembly including at least a piston rod movable in a front-rear direction, the impact member having an energy storage state and an impact state in the cylinder barrel When the impact member is in an energy storage state, the impact member is stationary, and the human-driven air supply device fills the chamber with gas; when the impact member is in an impact state, the impact member impacts forward and The piston rod is driven to move forward, and the energy storage needle-free injector further includes a control mechanism disposed on the cylinder
  • control mechanism includes a pawl rotatably disposed on the cylinder barrel, and one end of the pawl may abut against or be disengaged from the front end of the impact member.
  • control mechanism further includes an elastic member for driving the pawl to rotate against the front end of the impact member, the elastic member being disposed between the pawl and the cylinder.
  • the pawl is L-shaped.
  • the front end of the cylinder is open with a through hole communicating with the inner cavity, and the end of the pawl is rotatably inserted in the through hole.
  • the human-powered air supply device includes a body provided with an air flow passage, and the body is provided with a first one-way valve and a second portion that partition the air flow passage into a first air chamber and a second air chamber. a one-way valve and a relief valve, wherein the outside is unidirectionally communicated to the first air chamber through the first one-way valve, and the first air chamber passes through the second one-way valve to the second air chamber The one-way communication is disposed, and the second air chamber is in airflow communication with the chamber of the cylinder.
  • the manually driven air supply device further includes an air compression mechanism disposed on the body to allow outside air to enter the first air cavity through the first one-way valve.
  • the air compression mechanism includes a piston chamber disposed on the body and communicating with the first air chamber, and a piston movably disposed in the piston chamber for providing the piston along the moving direction A resilient restoring spring, one end rotatably coupled to the cylinder for operating an operating handle of the piston to move within the piston chamber, the body being part of the cylinder.
  • the air compression mechanism includes a piston chamber disposed on the body in communication with the first air chamber, and a piston movably disposed in the piston chamber for providing movement of the piston a spring directionalally resiliently responsive to one end rotatably coupled to the body for driving the piston to move in the piston chamber, the second air chamber and the chamber of the cylinder pass The intake lines are connected.
  • the rear end portion of the impact member is disposed in conformity with the rear end cylinder wall of the cylinder barrel.
  • the present invention has the following advantages over the prior art: the human-powered energy-storing needle-free injector of the present invention, wherein the impact member is released by accumulating a certain forward moving potential energy. The impact is realized, and the piston rod of the needle-free ampoule assembly is moved to realize the injection of the liquid medicine.
  • the impact member impacts, the initial acceleration is large, and the idle stroke can be greatly shortened, so that the volume of the needle-free injector is greatly reduced.
  • the needle-free injector has a simple structure and is convenient to use.
  • FIG. 1 is a schematic structural view of a needle-free injector according to Embodiment 1 of the present invention in an energy storage state;
  • FIG. 2 is a schematic structural view of a needle-free injector according to Embodiment 1 of the present invention in an impact state;
  • FIG. 3 is a schematic structural view of a needle-free injector according to Embodiment 2 of the present invention in an energy storage state;
  • a needleless injector shown in Fig. 1 and Fig. 2, including a cylinder tube 1 having an inner cavity, and a front end cover fixed to the front end of the cylinder tube 2 a needle-free ampoule assembly 5 mounted on the front end cover 2, an impact member 3 which is movable in the inner cavity of the cylinder tube 1 and movable in the front-rear direction, a human-powered air supply device for supplying compressed air 6, and an impact member 3
  • a closed chamber 11 is formed in the cylinder 1 and the rear portion of the cylinder tube 1, and the chamber 11 is filled with compressed air by a human-powered air supply device 6 to drive the impact member 3 in the cylinder tube 1 Move forward in the lumen.
  • the needleless ampoule assembly 5 is detachably mounted on the front end cover 2, which makes it easy to remove and replace it after one injection.
  • the needleless ampoule assembly 5 includes a syringe having a chemical liquid chamber 52, a piston rod 51 movable in the front-rear direction, and at least a portion of the rear portion of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1 through an opening at the front end of the cylinder tube 1 when impacted Piece 3 When the front impacts, the piston rod 51 is moved forward to push the liquid to achieve the injection.
  • the piston rod 51 is driven to move forward to complete the injection, and the impact member 3 In the cylinder tube 1, there is an energy storage state and an impact state.
  • the energy storage state the impact member 3 is stationary, and the human-powered air supply device 6 continuously fills the chamber 11 of the cylinder tube 1 with compressed air, so that the impact member 3 The potential energy moving forward is continuously accumulated; when the impact member 3 is in an impact state, the impact member 3 strikes forward and drives the piston rod 51 to move forward.
  • the rear end of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1, and the piston rod 51
  • the rear end and the front end of the impact member 3 should have a proper distance, that is, the impact member 3 has a certain distance between the front end and the rear end of the piston rod 51 in the state of energy storage, so that the impact member 3 After accumulating energy, the piston rod 51 is driven to the impact state.
  • the impact member 3 hits the piston rod 51 to reach a higher speed, so that the piston rod 51 Initially, it can be impacted at a faster speed to avoid the initial flow of the drug and the inability to enter the patient.
  • a control mechanism 4 for switching the working state of the impact member 3 is also provided on the cylinder tube 1. See Figure 1 and Figure 2 As shown in the present embodiment, the control mechanism 4 includes a pawl 41 which is rotatably provided on the cylinder barrel 1 via a rotating shaft 43.
  • the pawl 41 has an L-shaped structure, and the cylinder tube 1
  • the upper opening is provided with a through hole 12 communicating with the inner cavity thereof, and the pawl end of the front portion of the pawl 41 is rotatably inserted into the through hole 12 and abuts against the front end of the impact member 3, or is rotatably disengaged from the front end of the impact member 3.
  • pawl A spring 42 is disposed between the rear end of the 41 and the cylinder tube 1.
  • the spring 42 should have a good rigidity so that under normal conditions, the spring 42 generates an elastic force that pushes the pawl 41 outward, and the pawl 41
  • the pawl end of the front portion abuts against the front end of the impact member 3, so that the impact member 3 is in an energy storage state, and when the injection is required after the end of the energy storage, the spine is pressed against the rear end of the pawl 41 to overcome the elastic force of the spring 42.
  • claw 41 Rotate away from the impact member 3, the impact member 3 strikes forward and drives the piston rod 51 to move forward to achieve injection.
  • the human-powered air supply unit 6 includes a body 61 having an air flow passage, where the body 61 It is the rear end wall of the cylinder tube 1.
  • the body 61 is provided with a first check valve 62, a second check valve 64 and a relief valve 66 for separating the above air flow passage into the first air chamber 63 and the second air chamber 65.
  • the external air chamber 63 is disposed in one-way communication with the first air chamber 63 through the first one-way valve 62.
  • the first air chamber 63 is disposed in one-way communication with the second air chamber 65 through the second one-way valve 64.
  • the second air chamber 65 is provided.
  • the chamber 11 is connected to the gas flow, and the relief valve 66 is used for overflow relief when the gas pressure in the second gas chamber 65 exceeds a certain value.
  • the body 1 is also provided with an air compression mechanism capable of allowing outside air to enter the first air chamber 63 through the first one-way valve 62.
  • the air compression mechanism 7 includes a piston chamber disposed on the body 61 in communication with the first air chamber 63, and a piston 71 movably disposed in the piston chamber for providing the piston 71.
  • a spring 72 having an elastic restoring force in the moving direction is rotatably coupled to the cylinder 1 for operating the operating handle 73 for driving the piston 71 to move in the piston chamber.
  • Ontology 61 is further provided with a rear plug body 67 for blocking the vent hole. After the impact injection is completed, the rear plug body 67 can be pulled out, so that the gas in the chamber 11 is discharged through the vent hole, thereby causing the impact member 3 Move back to the position before the impact.
  • the pawl end of the pawl 41 abuts against the impact member 3, and the needle-free ampoule assembly containing the medical liquid is 5 Mounted to the front end cover 2, the rear portion of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1 and located in front of the impact member 3, and the rear end of the piston rod 51 is kept at a certain distance from the front end of the impact member 3, see 1 Shown.
  • the chamber 11 of the cylinder tube 1 is continuously filled with compressed air by holding the operation handle 73, and the chamber 11 The pressure inside is continuously increased, so that the impact member 3 continuously accumulates the potential energy moving forward.
  • the rear end of the pressing pawl 41 is mounted at the position of the spring 42, the spine claw 41 Rotating away from the impact member 3, the impact member 3 hits the piston rod 51 of the needle-free ampoule assembly 5 with rapid acceleration to achieve the injection of the chemical solution, as shown in Figure 2.
  • the plug body is pulled out. 67.
  • the gas in the inner chamber 11 of the cylinder 1 is discharged, and the impact member 3 is moved backward to realize the reset.
  • the difference from the embodiment 1 is mainly the human-powered air supply device 6 setting.
  • the body 61 of the manually driven air supply device 6 is disposed separately from the cylinder tube 1, and the second chamber 65 of the manually driven air supply device 6 passes through the intake line 8 and the cylinder tube 1
  • the chamber 11 is in communication.
  • the operation handle 73 in the embodiment 1 is replaced with an operation pedal 74 which is rotatably provided on the body 61 at one end. Therefore, in operation, the operator only needs to step on the operating pedal 74 with the foot, so that the chamber 11 of the cylinder tube 1 is filled with gas, so that the impact member 3 is stored, and the operation is more labor-saving.
  • the intake line 8 since the intake line 8 is connected, the intake line 8 The lumen can form a chamber for storing compressed air, and therefore, in the present embodiment, the impact member 3 can be attached to the rear end cover 13 at the rear end of the cylinder 1, which further reduces the volume of the needle-free injector.
  • the impact piece 3 The rear end is blocked on the mouth of the air flow passage on the rear end cover 13, and the chamber can be sealed to continuously store compressed gas to prevent the compressed gas from escaping, the impact member 3 and the cylinder tube 1
  • the seal between the settings, the structure is simpler, and the manufacturing process is also better.
  • the rear end of the impact member 3 is also provided with a recess 31 to avoid the impact member 3 It cannot be completely attached to the rear end cover 13.
  • the human-powered energy-storing needle-free injector of the present invention wherein the impact member 3 is passed Accumulating a certain potential energy for moving forward, and then releasing it to achieve an impact, thereby driving the piston rod 51 of the needleless ampoule assembly 5 to move, thereby injecting the liquid medicine, and the impact member 3
  • the initial acceleration is large, and the idle stroke can be greatly shortened, so that the volume of the needle-free injector is greatly reduced.
  • the needle-free injector has a simple structure and is convenient to use.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un injecteur sans aiguille à stockage d'énergie et actionné manuellement, comprenant un tube cylindrique (1) possédant une cavité interne, une protection d'extrémité avant (2) disposée à demeure au niveau de l'extrémité avant du tube cylindrique (1), un ensemble ampoule sans aiguille (5) installé sur la protection d'extrémité avant (2) et une pièce de percussion (3) se déplaçant selon un mouvement de va-et-vient dans le tube cylindrique (1). La pièce de percussion (3) forme une cavité fermée (11) avec la partie arrière du tube cylindrique (1) dans le tube cylindrique (1). L''injecteur sans aiguille comprend, en outre, un dispositif d'alimentation en air (6), actionné manuellement et servant à remplir la cavité (11) d'air comprimé. L'ensemble ampoule sans aiguille (5) comprend au moins une tige de piston (51) capable de se déplacer selon un mouvement de va-et-vient et le tube cylindrique (1) est également pourvu d'un mécanisme de commande (4) utilisé pour modifier le statut de fonctionnement de la pièce de percussion (3). L'injecteur sans aiguille utilise la pièce de percussion (3) pour stocker une énergie potentielle donnée de déplacement vers l'avant et pour libérer cette énergie potentielle de manière à ce qu'il y ait percussion et, ainsi, faire que la tige de piston (51) de l'ensemble ampoule sans aiguille (5) injecte le médicament liquide. Lorsque la pièce de percussion (3) frappe, la vitesse initiale d'accélération est plus grande, ce qui raccourcit considérablement la course à vide, avec pour résultat une grande diminution de l'encombrement de l'injecteur sans aiguille.
PCT/CN2015/078574 2014-05-14 2015-05-08 Injecteur sans aiguille à stockage d'énergie et actionné manuellement WO2015172683A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410202794.X 2014-05-14
CN201410202794.XA CN103977480B (zh) 2014-05-14 2014-05-14 一种人力驱动的蓄能式无针注射器

Publications (1)

Publication Number Publication Date
WO2015172683A1 true WO2015172683A1 (fr) 2015-11-19

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CN (1) CN103977480B (fr)
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Cited By (1)

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CN115737992A (zh) * 2022-11-24 2023-03-07 深圳市博迈本尚医疗科技有限公司 无针注射器

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CN103977480B (zh) * 2014-05-14 2016-06-15 苏州大学张家港工业技术研究院 一种人力驱动的蓄能式无针注射器
CN105498044A (zh) * 2016-01-13 2016-04-20 北京步腾医学科技有限公司 一次性气动无针注射器及其使用方法
CN105498045A (zh) * 2016-01-13 2016-04-20 北京步腾医学科技有限公司 一种无针弹簧注射器
CN106334240B (zh) * 2016-11-05 2019-05-21 王礼华 一种无针注射器
CN106498651B (zh) * 2016-11-17 2019-10-11 上海电机学院 一种脚踏气压式洗衣机
CN110051909B (zh) * 2017-03-20 2021-07-16 江西旺来科技有限公司 可连续注射的无针注射器
CN109655344B (zh) * 2017-10-10 2023-12-15 中国人民解放军空军特色医学中心 压力冲击模拟装置
KR101859735B1 (ko) * 2018-02-07 2018-05-21 주식회사 피테크 무통 주사 장치
CN111481774B (zh) * 2019-01-25 2023-06-09 凯联医疗科技(上海)有限公司 一种微量药物无针注射器
KR102248430B1 (ko) * 2019-04-22 2021-05-06 주식회사 피테크 휴대용 무바늘 무통 주사 장치
CN113995917B (zh) * 2021-11-04 2023-07-14 周健 注射器
CN114984379B (zh) * 2022-05-18 2024-02-09 浙江工业大学 高压驱动无针注射装置
CN115154766B (zh) * 2022-06-21 2023-10-20 江苏乐聚医药科技有限公司 用于无针注射器的自激发装置

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WO2012092715A1 (fr) * 2011-01-07 2012-07-12 无锡圆容生物医药股份有限公司 Injecteur sans aiguille de type à impact pneumatique à amortissement magnétique
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CN103977480A (zh) * 2014-05-14 2014-08-13 苏州大学张家港工业技术研究院 一种人力驱动的蓄能式无针注射器
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CN203898859U (zh) * 2014-05-14 2014-10-29 苏州大学张家港工业技术研究院 电磁蓄能式无针注射器

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737992A (zh) * 2022-11-24 2023-03-07 深圳市博迈本尚医疗科技有限公司 无针注射器
CN115737992B (zh) * 2022-11-24 2024-06-07 深圳市本尚医疗科技有限公司 无针注射器

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CN103977480A (zh) 2014-08-13
CN103977480B (zh) 2016-06-15

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