WO2015172683A1

WO2015172683A1 - Manually operated energy storing needleless injector

Info

Publication number: WO2015172683A1
Application number: PCT/CN2015/078574
Authority: WO
Inventors: 孙万平; 王明娣; 王传洋; 窦云霞
Original assignee: 苏州大学张家港工业技术研究院
Priority date: 2014-05-14
Filing date: 2015-05-08
Publication date: 2015-11-19
Also published as: CN103977480A; CN103977480B

Abstract

A manually operated energy storing needleless injector, comprising a cylinder tube (1) having an inner cavity, a front end cover (2) fixedly disposed at the front end of the cylinder tube (1), a needleless ampoule assembly (5) installed on the front end cover (2), and an impacting piece (3) moving back and forth in the cylinder tube (1); the impacting piece (3) forms an enclosed cavity (11) with the back portion of the cylinder tube (1) in the cylinder tube (1); the needleless injector further comprises a manually operated air-supplying device (6) for filling the cavity (11) with compressed air; the needleless ampoule assembly (5) at least comprises a piston rod (51) capable of moving back and forth; and the cylinder tube (1) is also provided with a control mechanism (4) for switching the operating status of the impacting piece (3). The needleless injector uses the impacting piece (3) to store a given forward-moving potential energy and to release the potential energy so as to realize impact and thus to drive the piston rod (51) of the needleless ampoule assembly (5) to inject the liquid drug. When the impacting piece (3) impacts, the initial accelerated speed is greater, thus greatly shortening an idle travel, dramatically reducing the volume of the needleless injector.

Description

Human-powered energy storage needleless syringe

Technical field

The present invention relates to a human-powered, energy-storing needle-free injector.

Background technique

The needle-free injection technology is used for drug injection without the aid of a needle. The liquid medicine directly enters the body tissue by means of ultra-fine, high-speed, straight-line high-pressure jet, which solves a series of problems caused by the needle injection into the body. Such as: pain, bleeding, infection, tissue damage, psychological pressure of patients, etc.; at the same time, the distribution of drugs without needle injection in the tissue is more diffuse, which is conducive to the absorption of drugs, long-term injection of skin is not easy to induration. Therefore, needle-free injection technology has broad application prospects, especially for children vaccination and diabetes patients.

In the prior art, the human-powered needle-free injector generally works by the principle of spring energy storage and instant firing. For example, the Chinese patent number is ZL201320568118.5, and the patent name is the structure in the 'needle-free injector', and the advantage is the structure. The simple operation and the injection operation are convenient; the main disadvantage is that the firing device of the syringe is separated from the device for resetting and storing the spring, and the resetting operation is extremely inconvenient, and is not suitable for the occasion requiring continuous rapid injection.

Summary of the invention

SUMMARY OF THE INVENTION It is an object of the present invention to provide a human-powered, energy-storing needle-free injector that is simple in construction and convenient to use.

In order to achieve the above object, the technical solution adopted by the present invention is:

A human-powered energy-storing needle-free injector comprising a cylinder having a lumen, a front end cover fixed to the front end of the cylinder, and a needle-free ampoule assembly mounted on the front end cover, An impact member that is movably disposed in the cylinder barrel in a front-rear direction, a closed chamber is disposed between the impact member and the rear portion of the cylinder barrel, and the needle-free injector further includes a chamber for the chamber a human-powered air supply device filled with a compressed gas, the needleless ampoule assembly including at least a piston rod movable in a front-rear direction, the impact member having an energy storage state and an impact state in the cylinder barrel When the impact member is in an energy storage state, the impact member is stationary, and the human-driven air supply device fills the chamber with gas; when the impact member is in an impact state, the impact member impacts forward and The piston rod is driven to move forward, and the energy storage needle-free injector further includes a control mechanism disposed on the cylinder for switching the working state of the impact member.

Preferably, there is a gap between the front end of the impact member and the rear end of the piston rod when the impact member is in an energy storage state.

Preferably, the control mechanism includes a pawl rotatably disposed on the cylinder barrel, and one end of the pawl may abut against or be disengaged from the front end of the impact member.

More preferably, the control mechanism further includes an elastic member for driving the pawl to rotate against the front end of the impact member, the elastic member being disposed between the pawl and the cylinder.

More preferably, the pawl is L-shaped.

More preferably, the front end of the cylinder is open with a through hole communicating with the inner cavity, and the end of the pawl is rotatably inserted in the through hole.

Preferably, the human-powered air supply device includes a body provided with an air flow passage, and the body is provided with a first one-way valve and a second portion that partition the air flow passage into a first air chamber and a second air chamber. a one-way valve and a relief valve, wherein the outside is unidirectionally communicated to the first air chamber through the first one-way valve, and the first air chamber passes through the second one-way valve to the second air chamber The one-way communication is disposed, and the second air chamber is in airflow communication with the chamber of the cylinder.

More preferably, the manually driven air supply device further includes an air compression mechanism disposed on the body to allow outside air to enter the first air cavity through the first one-way valve.

Further, the air compression mechanism includes a piston chamber disposed on the body and communicating with the first air chamber, and a piston movably disposed in the piston chamber for providing the piston along the moving direction A resilient restoring spring, one end rotatably coupled to the cylinder for operating an operating handle of the piston to move within the piston chamber, the body being part of the cylinder.

Further, the air compression mechanism includes a piston chamber disposed on the body in communication with the first air chamber, and a piston movably disposed in the piston chamber for providing movement of the piston a spring directionalally resiliently responsive to one end rotatably coupled to the body for driving the piston to move in the piston chamber, the second air chamber and the chamber of the cylinder pass The intake lines are connected.

Further, when the impact member is in an energy storage state, the rear end portion of the impact member is disposed in conformity with the rear end cylinder wall of the cylinder barrel.

Due to the use of the above technical solutions, the present invention has the following advantages over the prior art: the human-powered energy-storing needle-free injector of the present invention, wherein the impact member is released by accumulating a certain forward moving potential energy. The impact is realized, and the piston rod of the needle-free ampoule assembly is moved to realize the injection of the liquid medicine. When the impact member impacts, the initial acceleration is large, and the idle stroke can be greatly shortened, so that the volume of the needle-free injector is greatly reduced. The needle-free injector has a simple structure and is convenient to use.

DRAWINGS

1 is a schematic structural view of a needle-free injector according to Embodiment 1 of the present invention in an energy storage state;

2 is a schematic structural view of a needle-free injector according to Embodiment 1 of the present invention in an impact state;

3 is a schematic structural view of a needle-free injector according to Embodiment 2 of the present invention in an energy storage state;

Among them: 1 , cylinder; 11 , chamber; 12 , through hole; 13 , back cover; 2, front cover; 3, impact parts; 31, groove; 4, control mechanism; 41, pawl; 42, spring; 43, shaft; 5, needle-free ampoule assembly; 51, piston rod; 52, liquid chamber; , human-driven air supply device; 61, body; 62, first check valve; 63, first air chamber; 64, second check valve; 65, second air chamber; 66, overflow valve; Rear plug body; 7, air compression mechanism; 71, piston; 72, spring; 73, operating handle; 74, operating pedal.

detailed description

The technical solutions of the present invention are further described below in conjunction with the accompanying drawings and specific embodiments.

The following description of the directions is defined in accordance with the direction observed by the operator during the injection operation, wherein the injection end is the front and vice versa.

Example 1

Referring to the needleless injector shown in Fig. 1 and Fig. 2, including a cylinder tube 1 having an inner cavity, and a front end cover fixed to the front end of the cylinder tube 2 a needle-free ampoule assembly 5 mounted on the front end cover 2, an impact member 3 which is movable in the inner cavity of the cylinder tube 1 and movable in the front-rear direction, a human-powered air supply device for supplying compressed air 6, and an impact member 3 A closed chamber 11 is formed in the cylinder 1 and the rear portion of the cylinder tube 1, and the chamber 11 is filled with compressed air by a human-powered air supply device 6 to drive the impact member 3 in the cylinder tube 1 Move forward in the lumen.

The needleless ampoule assembly 5 is detachably mounted on the front end cover 2, which makes it easy to remove and replace it after one injection. The needleless ampoule assembly 5 includes a syringe having a chemical liquid chamber 52, a piston rod 51 movable in the front-rear direction, and at least a portion of the rear portion of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1 through an opening at the front end of the cylinder tube 1 when impacted Piece 3 When the front impacts, the piston rod 51 is moved forward to push the liquid to achieve the injection.

In order to enable the impact member 3 to impact forward with a large impact force during injection, the piston rod 51 is driven to move forward to complete the injection, and the impact member 3 In the cylinder tube 1, there is an energy storage state and an impact state. In the energy storage state, the impact member 3 is stationary, and the human-powered air supply device 6 continuously fills the chamber 11 of the cylinder tube 1 with compressed air, so that the impact member 3 The potential energy moving forward is continuously accumulated; when the impact member 3 is in an impact state, the impact member 3 strikes forward and drives the piston rod 51 to move forward.

When the needleless ampoule assembly 5 is mounted on the front end cover 2, the rear end of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1, and the piston rod 51 The rear end and the front end of the impact member 3 should have a proper distance, that is, the impact member 3 has a certain distance between the front end and the rear end of the piston rod 51 in the state of energy storage, so that the impact member 3 After accumulating energy, the piston rod 51 is driven to the impact state. When the impact is injected, the impact member 3 hits the piston rod 51 to reach a higher speed, so that the piston rod 51 Initially, it can be impacted at a faster speed to avoid the initial flow of the drug and the inability to enter the patient.

A control mechanism 4 for switching the working state of the impact member 3 is also provided on the cylinder tube 1. See Figure 1 and Figure 2 As shown in the present embodiment, the control mechanism 4 includes a pawl 41 which is rotatably provided on the cylinder barrel 1 via a rotating shaft 43. The pawl 41 has an L-shaped structure, and the cylinder tube 1 The upper opening is provided with a through hole 12 communicating with the inner cavity thereof, and the pawl end of the front portion of the pawl 41 is rotatably inserted into the through hole 12 and abuts against the front end of the impact member 3, or is rotatably disengaged from the front end of the impact member 3. pawl A spring 42 is disposed between the rear end of the 41 and the cylinder tube 1. The spring 42 should have a good rigidity so that under normal conditions, the spring 42 generates an elastic force that pushes the pawl 41 outward, and the pawl 41 The pawl end of the front portion abuts against the front end of the impact member 3, so that the impact member 3 is in an energy storage state, and when the injection is required after the end of the energy storage, the spine is pressed against the rear end of the pawl 41 to overcome the elastic force of the spring 42. claw 41 Rotate away from the impact member 3, the impact member 3 strikes forward and drives the piston rod 51 to move forward to achieve injection.

Referring to Figures 1 and 2, the human-powered air supply unit 6 includes a body 61 having an air flow passage, where the body 61 It is the rear end wall of the cylinder tube 1. The body 61 is provided with a first check valve 62, a second check valve 64 and a relief valve 66 for separating the above air flow passage into the first air chamber 63 and the second air chamber 65. The external air chamber 63 is disposed in one-way communication with the first air chamber 63 through the first one-way valve 62. The first air chamber 63 is disposed in one-way communication with the second air chamber 65 through the second one-way valve 64. The second air chamber 65 is provided. With cylinder The chamber 11 is connected to the gas flow, and the relief valve 66 is used for overflow relief when the gas pressure in the second gas chamber 65 exceeds a certain value.

The body 1 is also provided with an air compression mechanism capable of allowing outside air to enter the first air chamber 63 through the first one-way valve 62. The air compression mechanism 7 includes a piston chamber disposed on the body 61 in communication with the first air chamber 63, and a piston 71 movably disposed in the piston chamber for providing the piston 71. A spring 72 having an elastic restoring force in the moving direction is rotatably coupled to the cylinder 1 for operating the operating handle 73 for driving the piston 71 to move in the piston chamber. By holding the operating handle 73 The rotation thereof is driven to move the piston 72 so that the outside air is blown into the first air chamber 63, and the pressure in the first air chamber 63 is continuously increased, and the gas in the first air chamber 63 passes through the second one-way. Valve 64 It enters the second air chamber 65 and enters the chamber 11 of the cylinder 1. Pressing the operating handle 73 continuously causes the air pressure in the chamber 11 to continuously increase to accumulate the potential energy of the impact member 3 to move forward. Ontology 61 is further provided with a rear plug body 67 for blocking the vent hole. After the impact injection is completed, the rear plug body 67 can be pulled out, so that the gas in the chamber 11 is discharged through the vent hole, thereby causing the impact member 3 Move back to the position before the impact.

When the needle-free injector is in use, in an initial state, the pawl end of the pawl 41 abuts against the impact member 3, and the needle-free ampoule assembly containing the medical liquid is 5 Mounted to the front end cover 2, the rear portion of the piston rod 51 is inserted into the inner cavity of the cylinder tube 1 and located in front of the impact member 3, and the rear end of the piston rod 51 is kept at a certain distance from the front end of the impact member 3, see 1 Shown.

At the time of injection, first, the chamber 11 of the cylinder tube 1 is continuously filled with compressed air by holding the operation handle 73, and the chamber 11 The pressure inside is continuously increased, so that the impact member 3 continuously accumulates the potential energy moving forward. When the pressure in the chamber 11 is increased to a certain extent, the rear end of the pressing pawl 41 is mounted at the position of the spring 42, the spine claw 41 Rotating away from the impact member 3, the impact member 3 hits the piston rod 51 of the needle-free ampoule assembly 5 with rapid acceleration to achieve the injection of the chemical solution, as shown in Figure 2. After the injection is completed, the plug body is pulled out. 67. The gas in the inner chamber 11 of the cylinder 1 is discharged, and the impact member 3 is moved backward to realize the reset.

Due to the impact piece 3 When the energy storage reaches a certain impact, the initial acceleration will be large, and the empty stroke can be greatly shortened, so that the volume of the needle-free injector is greatly reduced. At the same time, only the operation handle 73 needs to be pressed during operation, which is convenient to use.

Example 2

Referring to the needle-free injector shown in Fig. 3, the difference from the embodiment 1 is mainly the human-powered air supply device 6 setting. In the present embodiment, the body 61 of the manually driven air supply device 6 is disposed separately from the cylinder tube 1, and the second chamber 65 of the manually driven air supply device 6 passes through the intake line 8 and the cylinder tube 1 The chamber 11 is in communication. Further, in the air compression mechanism 7, the operation handle 73 in the embodiment 1 is replaced with an operation pedal 74 which is rotatably provided on the body 61 at one end. Therefore, in operation, the operator only needs to step on the operating pedal 74 with the foot, so that the chamber 11 of the cylinder tube 1 is filled with gas, so that the impact member 3 is stored, and the operation is more labor-saving.

Further, in the present embodiment, since the intake line 8 is connected, the intake line 8 The lumen can form a chamber for storing compressed air, and therefore, in the present embodiment, the impact member 3 can be attached to the rear end cover 13 at the rear end of the cylinder 1, which further reduces the volume of the needle-free injector. At the same time, the impact piece 3 The rear end is blocked on the mouth of the air flow passage on the rear end cover 13, and the chamber can be sealed to continuously store compressed gas to prevent the compressed gas from escaping, the impact member 3 and the cylinder tube 1 The seal between the settings, the structure is simpler, and the manufacturing process is also better. In this arrangement, in order to smoothly reset the impact member 3, the rear end of the impact member 3 is also provided with a recess 31 to avoid the impact member 3 It cannot be completely attached to the rear end cover 13.

In summary, the human-powered energy-storing needle-free injector of the present invention, wherein the impact member 3 is passed Accumulating a certain potential energy for moving forward, and then releasing it to achieve an impact, thereby driving the piston rod 51 of the needleless ampoule assembly 5 to move, thereby injecting the liquid medicine, and the impact member 3 At the time of impact, the initial acceleration is large, and the idle stroke can be greatly shortened, so that the volume of the needle-free injector is greatly reduced. The needle-free injector has a simple structure and is convenient to use.

The above embodiments are merely illustrative of the technical concept and the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the present invention and to implement the present invention, and the scope of the present invention is not limited thereto. Equivalent variations or modifications made in accordance with the spirit of the invention are intended to be included within the scope of the invention.

Claims

A human-powered energy-storing needle-free injector, characterized in that the needle-free injector comprises a cylinder having an inner cavity, a front end cover fixed to the front end of the cylinder, and a front mounted on the front cover a needle ampule assembly, an impact member that is movably disposed in the cylinder barrel in a front-rear direction, and a closed chamber between the impact member and the rear portion of the cylinder barrel, the needle-free injector further comprising a human-powered air supply device filled with a compressed gas in the chamber, the needleless ampoule assembly including at least a piston rod movable in a front-rear direction, the impact member having an energy storage state and an impact state in the cylinder tube When the impact member is in an energy storage state, the impact member is stationary, and the human-driven air supply device fills the chamber with gas; when the impact member is in an impact state, the impact member The piston rod is forwardly moved and driven to move forward. The accumulator needleless injector further includes a control mechanism disposed on the cylinder for switching the working state of the impact member.
According to claim 1 The human-powered energy-storing needle-free injector is characterized in that there is a gap between the front end of the impact member and the rear end of the piston rod when the impact member is in an energy storage state.
According to claim 1 The human-powered energy-storing needle-free injector is characterized in that: the control mechanism includes a pawl rotatably disposed on the cylinder, and one end of the pawl can resist the impact member The front end is detached from the impact member.
According to claim 3 The human-powered energy-storing needle-free injector is characterized in that: the control mechanism further comprises an elastic member for driving the pawl to rotate against the front end of the impact member, the elastic member being disposed on Between the pawl and the cylinder.
A human-powered, energy-storing needle-free injector according to claim 3, wherein said pawl is L-shaped.
According to claim 3 The human-powered energy-storing needle-free injector is characterized in that: the front end of the cylinder tube is provided with a through hole communicating with the inner cavity thereof, and the end portion of the pawl is rotatably inserted therein Said in the through hole.
According to claim 1 The human-powered energy-storing needle-free injector is characterized in that: the human-powered air supply device comprises a body provided with an air flow passage, and the body is provided with a partitioning the air flow passage into a first air chamber a first check valve, a second check valve, and a relief valve of the second air chamber, wherein the outside is unidirectionally communicated to the first air chamber through the first check valve, and the first air chamber passes The second one-way valve is disposed in one-way communication with the second air chamber, and the second air chamber is in airflow communication with the chamber of the cylinder.
According to claim 7 The human-powered energy-storing needle-free injector is characterized in that the human-powered air supply device further comprises a device disposed on the body for allowing outside air to enter the first through the first one-way valve An air compression mechanism in an air chamber.
According to claim 8 The human-powered energy-storing needle-free injector is characterized in that: the air compression mechanism comprises a piston chamber disposed on the body and communicating with the first air chamber, and is movably disposed on the piston a piston in the cavity, a spring for providing an elastic restoring force of the piston in the moving direction, and an operating handle rotatably connected to the cylinder for driving the piston to move in the piston cavity, the body It is part of the cylinder.
According to claim 8 The human-powered energy-storing needle-free injector is characterized in that: the air compression mechanism comprises a piston chamber disposed on the body and communicating with the first air chamber, and is movably disposed on the piston a piston in the cavity, a spring for providing an elastic restoring force of the piston in the moving direction, and an operating pedal rotatably coupled to the body for driving the piston to move in the piston cavity, the second The air chamber is in communication with the chamber of the cylinder through an intake line.
According to claim 10 The human-powered energy-storing needle-free injector is characterized in that: when the impact member is in an energy storage state, a rear end portion of the impact member is disposed in close contact with a rear end cylinder wall of the cylinder tube .