WO2015153880A3 - Modulation de hotair et de l'adipogenèse - Google Patents

Modulation de hotair et de l'adipogenèse Download PDF

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Publication number
WO2015153880A3
WO2015153880A3 PCT/US2015/024079 US2015024079W WO2015153880A3 WO 2015153880 A3 WO2015153880 A3 WO 2015153880A3 US 2015024079 W US2015024079 W US 2015024079W WO 2015153880 A3 WO2015153880 A3 WO 2015153880A3
Authority
WO
WIPO (PCT)
Prior art keywords
adipose
hotair
adipogenesis
formation
modulation
Prior art date
Application number
PCT/US2015/024079
Other languages
English (en)
Other versions
WO2015153880A2 (fr
Inventor
Jeremy J. Mao
Guodong Yang
Original Assignee
The Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York filed Critical The Trustees Of Columbia University In The City Of New York
Publication of WO2015153880A2 publication Critical patent/WO2015153880A2/fr
Publication of WO2015153880A3 publication Critical patent/WO2015153880A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des compositions et des procédés de formation de tissu adipeux. Dans un aspect, l'invention porte en particulier sur un procédé comprenant la mise en contact d'adipocytes progénitrices et d'un agent de modulation de l'ARN intergénique antisens HOX ("HOTAIR"), d'un exosome provenant d'un tissu adipeux, d'un miARN associé à un exosome provenant d'un tissu adipeux, ou d'un agent de déméthylation. Un tel contact peut induire ou augmenter l'adipogenèse, la formation de tissu adipeux blanc, la formation de tissu adipeux brun, ou la transformation de tissu adipeux blanc en tissu adipeux brun.
PCT/US2015/024079 2014-04-02 2015-04-02 Modulation de hotair et de l'adipogenèse WO2015153880A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461974361P 2014-04-02 2014-04-02
US61/974,361 2014-04-02
US201462052868P 2014-09-19 2014-09-19
US62/052,868 2014-09-19

Publications (2)

Publication Number Publication Date
WO2015153880A2 WO2015153880A2 (fr) 2015-10-08
WO2015153880A3 true WO2015153880A3 (fr) 2015-12-10

Family

ID=54241444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/024079 WO2015153880A2 (fr) 2014-04-02 2015-04-02 Modulation de hotair et de l'adipogenèse

Country Status (1)

Country Link
WO (1) WO2015153880A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107090493A (zh) * 2017-03-01 2017-08-25 上海大学 一种产2‑mib蓝藻的探针杂交快速检测方法
CN118416015B (zh) * 2024-07-04 2024-09-06 西部生科生物医学科技(成都)有限公司 一种富含脂肪干细胞外泌体的组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009137613A2 (fr) * 2008-05-06 2009-11-12 Joslin Diabetes Center, Inc. Procédés et compositions pour induire une adipogenèse brune
WO2012045093A1 (fr) * 2010-10-01 2012-04-05 The Trustees Of Columbia University In The City Of New York Compositions et méthodes de nostocytose et d'adipogenèse
WO2014013029A1 (fr) * 2012-07-18 2014-01-23 Universität Duisburg-Essen Utilisation de préparations, comprenant des exosomes dérivés de cellules souches mésenchymateuses (csm), dans la prévention et la thérapie d'affections inflammatoires

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009137613A2 (fr) * 2008-05-06 2009-11-12 Joslin Diabetes Center, Inc. Procédés et compositions pour induire une adipogenèse brune
WO2012045093A1 (fr) * 2010-10-01 2012-04-05 The Trustees Of Columbia University In The City Of New York Compositions et méthodes de nostocytose et d'adipogenèse
WO2014013029A1 (fr) * 2012-07-18 2014-01-23 Universität Duisburg-Essen Utilisation de préparations, comprenant des exosomes dérivés de cellules souches mésenchymateuses (csm), dans la prévention et la thérapie d'affections inflammatoires

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DIVOUX, A ET AL.: "Identification Of A Novel IncRNA In Gluteal Adipose Tissue And Evidence For Its Positive Effect On Preadipocyte Differentiation.", OBESITY (SILVER SPRING)., vol. 22, no. 8, 2 May 2014 (2014-05-02), pages 1781 - 1785, XP055241888 *
KLENGEL, T ET AL.: "Allele-Specific FKBP5 DNA Demethylation Mediates Gene -Childhood Trauma Interactions.", NAT NEUROSCI., vol. 16, no. 1, January 2013 (2013-01-01), pages 33 - 41, XP055241884 *

Also Published As

Publication number Publication date
WO2015153880A2 (fr) 2015-10-08

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