WO2015147950A3 - Composés radioiodés - Google Patents

Composés radioiodés Download PDF

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Publication number
WO2015147950A3
WO2015147950A3 PCT/US2015/010048 US2015010048W WO2015147950A3 WO 2015147950 A3 WO2015147950 A3 WO 2015147950A3 US 2015010048 W US2015010048 W US 2015010048W WO 2015147950 A3 WO2015147950 A3 WO 2015147950A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
reagents
radioiodinated compounds
iodines
nucleotides
Prior art date
Application number
PCT/US2015/010048
Other languages
English (en)
Other versions
WO2015147950A2 (fr
Inventor
Stephen Dimagno
Bao HU
Original Assignee
Nutech Ventures
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutech Ventures filed Critical Nutech Ventures
Priority to CA2935856A priority Critical patent/CA2935856A1/fr
Priority to CN201580007012.XA priority patent/CN106536490A/zh
Priority to AU2015237282A priority patent/AU2015237282B2/en
Priority to US15/109,608 priority patent/US10053423B2/en
Priority to EP15769853.1A priority patent/EP3089962B1/fr
Priority to JP2016544437A priority patent/JP6563401B2/ja
Priority to ES15769853T priority patent/ES2731050T3/es
Publication of WO2015147950A2 publication Critical patent/WO2015147950A2/fr
Publication of WO2015147950A3 publication Critical patent/WO2015147950A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/08—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/30—Only oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des réactifs et des procédés utiles dans la synthèse d'iodes aryliques, par exemple dans la préparation de radio-traceurs marqués à l'iode. Les réactifs et les procédés selon l'invention peuvent être utilisés pour accéder à une plage étendue de composés, dont des composés aromatiques, des composés hétéroaromatiques, des acides aminés, des nucléotides et des composés synthétiques.
PCT/US2015/010048 2014-01-03 2015-01-02 Composés radioiodés WO2015147950A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2935856A CA2935856A1 (fr) 2014-01-03 2015-01-02 Composes radioiodes
CN201580007012.XA CN106536490A (zh) 2014-01-03 2015-01-02 放射性碘代化合物
AU2015237282A AU2015237282B2 (en) 2014-01-03 2015-01-02 Radioiodinated compounds
US15/109,608 US10053423B2 (en) 2014-01-03 2015-01-02 Radioiodinated compounds
EP15769853.1A EP3089962B1 (fr) 2014-01-03 2015-01-02 Composés radioiodés
JP2016544437A JP6563401B2 (ja) 2014-01-03 2015-01-02 放射性ヨウ素化化合物
ES15769853T ES2731050T3 (es) 2014-01-03 2015-01-02 Compuestos radioyodados

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461923541P 2014-01-03 2014-01-03
US61/923,541 2014-01-03

Publications (2)

Publication Number Publication Date
WO2015147950A2 WO2015147950A2 (fr) 2015-10-01
WO2015147950A3 true WO2015147950A3 (fr) 2016-03-03

Family

ID=54196540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/010048 WO2015147950A2 (fr) 2014-01-03 2015-01-02 Composés radioiodés

Country Status (8)

Country Link
US (1) US10053423B2 (fr)
EP (1) EP3089962B1 (fr)
JP (1) JP6563401B2 (fr)
CN (1) CN106536490A (fr)
AU (1) AU2015237282B2 (fr)
CA (1) CA2935856A1 (fr)
ES (1) ES2731050T3 (fr)
WO (1) WO2015147950A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6225838B2 (ja) * 2014-06-06 2017-11-08 株式会社デンソー 混合物輸送装置および混合物
JP2018518492A (ja) * 2015-06-12 2018-07-12 ニューテック・ベンチャーズ 放射ヨウ素標識された生体共役反応試薬
EP3380447A1 (fr) * 2015-11-24 2018-10-03 Institut National de la Sante et de la Recherche Medicale (INSERM) Procédé de synthèse d'iodo- ou d'astatoarènes en utilisant des sels de diaryliodonium
JP2020514367A (ja) * 2017-03-14 2020-05-21 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 細胞死の誘導のためのｂａｘ活性化の小分子敏感化
EP3682906A1 (fr) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Composé ciblant le transporteur de norépinéphrine
EP4218831A4 (fr) * 2020-09-28 2024-03-06 National Institutes for Quantum Science and Technology Procédé de production d'une substance marquée radioactive, dispositif de production d'une substance marquée radioactive, et procédé d'évaporation et de concentration de nucléide métallique radioactif

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048170A2 (fr) * 2008-10-21 2010-04-29 Board Of Regents Of The University Of Nebraska Fluoration de systèmes cycliques aromatiques
WO2013003734A2 (fr) * 2011-06-30 2013-01-03 Nutech Ventures Fluoration de systèmes cycliques aromatiques
WO2013184484A1 (fr) * 2012-06-05 2013-12-12 Nutech Ventures Procédés et réactifs pour préparer des sels de diaryliodonium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS265357B1 (cs) * 1987-04-28 1989-10-13 Hradilek Pavel Způsob zavádění radioaktivního izotopu jodu do m-jodbenzylguanidinu
GB0407952D0 (en) 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US8377704B2 (en) * 2009-10-20 2013-02-19 Nutech Ventures Detection and quantification of anions
GB0921573D0 (en) * 2009-12-10 2010-01-27 Ge Healthcare Ltd Iodine radiolabelling method
JP2016503401A (ja) * 2012-10-27 2016-02-04 グランド・フルーア・ファーマスーティカルズ・インコーポレイテッド ジアリールヨードニウム塩を製造するための方法及び試薬

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048170A2 (fr) * 2008-10-21 2010-04-29 Board Of Regents Of The University Of Nebraska Fluoration de systèmes cycliques aromatiques
WO2013003734A2 (fr) * 2011-06-30 2013-01-03 Nutech Ventures Fluoration de systèmes cycliques aromatiques
WO2013184484A1 (fr) * 2012-06-05 2013-12-12 Nutech Ventures Procédés et réactifs pour préparer des sels de diaryliodonium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEEVERS ET AL.: "Radioiodination techniques for small organic molecules", CHEMICAL REVIEWS, vol. 82, no. 6, 1982, pages 575 - 590, XP055358796 *

Also Published As

Publication number Publication date
CA2935856A1 (fr) 2015-10-01
EP3089962A4 (fr) 2017-06-14
JP6563401B2 (ja) 2019-08-21
EP3089962B1 (fr) 2019-03-13
CN106536490A (zh) 2017-03-22
US10053423B2 (en) 2018-08-21
EP3089962A2 (fr) 2016-11-09
WO2015147950A2 (fr) 2015-10-01
AU2015237282A1 (en) 2016-07-21
JP2017502971A (ja) 2017-01-26
AU2015237282B2 (en) 2019-06-06
ES2731050T3 (es) 2019-11-13
US20160326109A1 (en) 2016-11-10

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