WO2015147705A3 - Procédé de préparation d'une nanoémulsion stérile de composés organiques perfluorés - Google Patents

Procédé de préparation d'une nanoémulsion stérile de composés organiques perfluorés Download PDF

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Publication number
WO2015147705A3
WO2015147705A3 PCT/RU2015/000318 RU2015000318W WO2015147705A3 WO 2015147705 A3 WO2015147705 A3 WO 2015147705A3 RU 2015000318 W RU2015000318 W RU 2015000318W WO 2015147705 A3 WO2015147705 A3 WO 2015147705A3
Authority
WO
WIPO (PCT)
Prior art keywords
pfoc
stabilizing additive
aqueous solution
sterile
emulsion
Prior art date
Application number
PCT/RU2015/000318
Other languages
English (en)
Russian (ru)
Other versions
WO2015147705A2 (fr
Inventor
Сергей Юрьевич ПУШКИН
Original Assignee
Сергей Юрьевич ПУШКИН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сергей Юрьевич ПУШКИН filed Critical Сергей Юрьевич ПУШКИН
Publication of WO2015147705A2 publication Critical patent/WO2015147705A2/fr
Publication of WO2015147705A3 publication Critical patent/WO2015147705A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0471—Perflubron, i.e. perfluoroctylbromide, C8F17Br emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne l'industrie chimico-pharmaceutique et se présente comme un procédé pour obtenir des nanoémulsions stériles stables de composés organiques perfluorés (COP) ayant une taille moyenne de particules de maximum 150 nanomètres, et de préférence 30-100 nanomètres, si possible entre 30 et 80 nanomètres, pour leur utilisation en médecine et dans le domaine vétérinaire, qui consiste à remplir le circuit de circulation d'une installation pour produire des nanoémulsions de COP avec une solution aqueuse d'un additif de stabilisation, de préférence un poloxamère, ajouter dans la solution aqueuse l'additif de stabilisation du mélange de COP puis homogénéiser le mélange de COP dans la solution aqueuse d'un additif de stabilisation pour obtenir une préémulsion de COP possédant la taille voulue de particules, et lors de la régulation thermostatique de la chambre de travail de l'homogénéisateur et des conduites, ajouter la préémulsion de COP obtenu dans une solution aqueuse et saline pour obtenir des nanoémulsions de COP ayant une concentration voulue de COP, un additif stabilisateur et des sels, retenir les nanoémulsions de COP à une température de 2-10C conditionner éventuellement le produit fini dans un emballage stérilisé de consommateur final puis congeler le produit fini.
PCT/RU2015/000318 2014-03-27 2015-05-21 Procédé de préparation d'une nanoémulsion stérile de composés organiques perfluorés WO2015147705A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2014106582/15A RU2557933C1 (ru) 2014-03-27 2014-03-27 Способ приготовления стерильной наноэмульсии перфторорганических соединений
RU2014106582 2014-03-27

Publications (2)

Publication Number Publication Date
WO2015147705A2 WO2015147705A2 (fr) 2015-10-01
WO2015147705A3 true WO2015147705A3 (fr) 2015-11-26

Family

ID=53762591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2015/000318 WO2015147705A2 (fr) 2014-03-27 2015-05-21 Procédé de préparation d'une nanoémulsion stérile de composés organiques perfluorés

Country Status (2)

Country Link
RU (1) RU2557933C1 (fr)
WO (1) WO2015147705A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11406722B2 (en) 2017-03-16 2022-08-09 The Board Of Regents Of The University Of Texas System Nanodroplets with improved properties
WO2023287316A1 (fr) * 2021-07-15 2023-01-19 Arshintseva Elena Valentinovna Émulsion de transmission de gaz pour administration intraveineuse

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014415A1 (fr) * 1992-12-24 1994-07-07 Hemagen/Pfc Emulsions d'hydrocarbure fluore
RU2070033C1 (ru) * 1994-11-28 1996-12-10 Воробьев Сергей Иванович Способ получения перфторуглеродных эмульсий для медицинских целей
RU2122404C1 (ru) * 1997-12-16 1998-11-27 Воробьев Сергей Иванович Способ получения эмульсии на основе перфторорганических соединений для медико-биологических целей
RU2206319C2 (ru) * 2000-07-20 2003-06-20 Открытое акционерное общество Научно-производственная фирма "Перфторан" Эмульсия перфторорганических соединений для медицинских целей, способ ее приготовления и способы лечения и профилактики заболеваний с ее использованием
RU2393849C2 (ru) * 2006-12-28 2010-07-10 Общество с ограниченной ответственностью "Биология и фармакология перфторсоединений" Эмульсия перфторорганических соединений медицинского назначения, способ ее приготовления и способ ее применения
WO2010121082A2 (fr) * 2009-04-15 2010-10-21 Oxygen Biotherapeutics, Inc. Émulsions de perfluorocarbones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014415A1 (fr) * 1992-12-24 1994-07-07 Hemagen/Pfc Emulsions d'hydrocarbure fluore
RU2070033C1 (ru) * 1994-11-28 1996-12-10 Воробьев Сергей Иванович Способ получения перфторуглеродных эмульсий для медицинских целей
RU2122404C1 (ru) * 1997-12-16 1998-11-27 Воробьев Сергей Иванович Способ получения эмульсии на основе перфторорганических соединений для медико-биологических целей
RU2206319C2 (ru) * 2000-07-20 2003-06-20 Открытое акционерное общество Научно-производственная фирма "Перфторан" Эмульсия перфторорганических соединений для медицинских целей, способ ее приготовления и способы лечения и профилактики заболеваний с ее использованием
RU2393849C2 (ru) * 2006-12-28 2010-07-10 Общество с ограниченной ответственностью "Биология и фармакология перфторсоединений" Эмульсия перфторорганических соединений медицинского назначения, способ ее приготовления и способ ее применения
WO2010121082A2 (fr) * 2009-04-15 2010-10-21 Oxygen Biotherapeutics, Inc. Émulsions de perfluorocarbones

Also Published As

Publication number Publication date
WO2015147705A2 (fr) 2015-10-01
RU2557933C1 (ru) 2015-07-27

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