WO2015144977A8 - Trpa1 modulators - Google Patents

Trpa1 modulators Download PDF

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Publication number
WO2015144977A8
WO2015144977A8 PCT/FI2015/000013 FI2015000013W WO2015144977A8 WO 2015144977 A8 WO2015144977 A8 WO 2015144977A8 FI 2015000013 W FI2015000013 W FI 2015000013W WO 2015144977 A8 WO2015144977 A8 WO 2015144977A8
Authority
WO
WIPO (PCT)
Prior art keywords
trpa1
trpa1 modulators
modulators
compounds
useful
Prior art date
Application number
PCT/FI2015/000013
Other languages
French (fr)
Other versions
WO2015144977A1 (en
Inventor
Riina ARVELA
Patrik Holm
Peteris Prusis
Anniina Vesalainen
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of WO2015144977A1 publication Critical patent/WO2015144977A1/en
Publication of WO2015144977A8 publication Critical patent/WO2015144977A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula I, wherein X, R1 and R2 are as defined in the claims, exhibit TRPA1 activity and useful as TRPA1 modulators.
PCT/FI2015/000013 2014-03-28 2015-03-27 Trpa1 modulators WO2015144977A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20140093 2014-03-28
FI20140093 2014-03-28

Publications (2)

Publication Number Publication Date
WO2015144977A1 WO2015144977A1 (en) 2015-10-01
WO2015144977A8 true WO2015144977A8 (en) 2015-10-29

Family

ID=53005580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2015/000013 WO2015144977A1 (en) 2014-03-28 2015-03-27 Trpa1 modulators

Country Status (3)

Country Link
AR (1) AR099881A1 (en)
TW (1) TW201620877A (en)
WO (1) WO2015144977A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102164756B1 (en) * 2012-10-01 2020-10-14 오리온 코포레이션 N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
FR3114235A1 (en) 2020-09-18 2022-03-25 Université Grenoble Alpes INHIBITION OF ASTROCYTIC TRPA1 CHANNEL AS A NEW NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE
IT202100015098A1 (en) 2021-06-09 2022-12-09 Flonext S R L TRPA1 CHANNEL ANTAGONIST COMPOUND FOR USE IN DEGENERATIVE DISEASES OF THE RETINA

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280707A1 (en) * 2008-05-05 2011-02-09 Allergan, Inc. Alpha2b and alpha2c agonists
KR102164756B1 (en) * 2012-10-01 2020-10-14 오리온 코포레이션 N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists

Also Published As

Publication number Publication date
TW201620877A (en) 2016-06-16
AR099881A1 (en) 2016-08-24
WO2015144977A1 (en) 2015-10-01

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