WO2015135419A1 - 杀虫组合物 - Google Patents

杀虫组合物 Download PDF

Info

Publication number
WO2015135419A1
WO2015135419A1 PCT/CN2015/073287 CN2015073287W WO2015135419A1 WO 2015135419 A1 WO2015135419 A1 WO 2015135419A1 CN 2015073287 W CN2015073287 W CN 2015073287W WO 2015135419 A1 WO2015135419 A1 WO 2015135419A1
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
etoxazole
pest
pesticidal composition
pyridazine
Prior art date
Application number
PCT/CN2015/073287
Other languages
English (en)
French (fr)
Inventor
李成应
布里斯托詹姆斯.T
罗昌炎
Original Assignee
江苏龙灯化学有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏龙灯化学有限公司 filed Critical 江苏龙灯化学有限公司
Publication of WO2015135419A1 publication Critical patent/WO2015135419A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals

Definitions

  • the present invention relates to a pesticide composition
  • a pesticide composition comprising a first active ingredient, etoxazole, and a second active ingredient, pyridazine, and more particularly to a pesticidal method.
  • Etoxazole is a brand new uniquely structured compound developed by Sumitomo Chemical Research. Its chemical name is: (RS)-5-tert-butyl-2-[2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazol-4-yl]benzene Ether, the molecular structural formula is formula (I):
  • Ethylazole has excellent control effects on spider mites, eucalyptus urophylla and whole claw mites, such as two-spotted spider mites, cinnabar spider mites, citrus red spiders, hawthorn and grape leaf mites. Its mode of action includes inhibition of the normal molting process and ovicidal activity, so it can effectively control the entire young age of the mites (eggs, cubs and nymphs). In addition, although ethazole can not directly kill mites, it has a good infertility to female mites. It can control cockroach pests that have developed resistance to existing acaricides. Acetazole has strong rain resistance and long-lasting effect.
  • the correct use period on fruit trees can reach more than 50 days, and the duration of use on cotton, vegetables and ornamental plants can reach more than 30 days. So far, no phytotoxicity caused by oxazol in the test concentrations in greenhouses and in the field has been observed. Very little or no harm to many beneficial insects and beneficial mites. Acetazole is an important member of the integrated pest management system.
  • Pyridazine has a good effect on a variety of chewing mouthparts and sucking mouthparts pests.
  • the method of use is emulsifiable water spray or powder dusting. This medicine has outstanding effects on rice pests, and it is safer for predators of rice pests to prey on cockroaches, and is less toxic to fish.
  • the residual amount in the valley is low, which is especially suitable for rice, and can control aphids, vertical leafhoppers, rice aphids, planthoppers, spider mites, thrips, rice blasts and the like.
  • red spider which is an arachnid pest. It is one of the important pests of various crops such as fruit trees, cotton, solanaceae, vegetables and ornamental flowers.
  • the common pests are many of them.
  • the mites mainly damage the leaves, stems and flowers of the plants, and suck the stems and leaves of the plants.
  • the initial leaves have a large number of yellow-brown spots with apex of needle tip size, and the later leaves begin to chlorotic or shrink from the bottom to the top. Sometimes it starts from the middle leaves of the plant, and the leaves gradually turn yellow and fall off. There are many generations of mites and strong reproductive ability.
  • the number of mites can be rapidly multiplied in a short period of time, causing great harm to crops. It is easy to produce drug resistance to acaricides. If it is not timely prevented when it occurs seriously, the leaves of the victim crop will lose green and white, and will fall off in advance. It can occur throughout the year in tropical and greenhouse conditions.
  • the temperature determines the developmental cycle, reproductive speed and the amount of eggs laid by the insects. Arid and hot climatic conditions often lead to its occurrence.
  • oxazinium has been used as an acaricide in agriculture.
  • the use of oxazinone in the early stage of the mites can effectively inhibit the increase in the number of mites, and the quick-acting effect is good, but when mites have occurred in large quantities
  • oxazinphos can gradually prevent its quantity, so that the duration of the effect is no more than 20 days, and once used, it can only control the effect of one generation of mites.
  • Ethylazole has a long-lasting effect, so it has a wide application period, but it is not effective for adult mites.
  • the onset time of red spiders on citrus, cotton, pear and vegetables is 7-10 days after the drug reaches the peak of death. So that the leaves lose their green color due to the damage of the red spider, but the duration of the effect can reach 30-45 days.
  • the activity of the individual compounds is good; however, they are not always sufficient to meet the high requirements that must be met by insecticides, acaricides or nematicides when used at low application rates or for individual pests.
  • a sex spectrum or a pesticidal composition that combines knockdown activity and prolonged control time or drug resistance management to delay resistance.
  • the present invention provides an insecticide composition which, by combining carbazole and oxazinone, provides a gain effect in the control effect and expands
  • the insecticidal spectrum improves the rapid and long-acting effects of pest control and delays the development of drug resistance.
  • a pesticidal composition including
  • the first active ingredient etoxazole
  • the first active ingredient etoxazole and the second active ingredient pyridazine are in a weight ratio of 1:100-100:1.
  • the first active ingredient etoxazole and the second active ingredient pyridazine are in a weight ratio of 1:50 to 50:1.
  • the first active ingredient etoxazole and the second active ingredient pyridazine are in a weight ratio of 1:10 to 10:1.
  • An insecticidal composition comprising a first active ingredient, etoxazole, and a second active ingredient, pyridazine, wherein the first active ingredient, etoxazole, and the second active ingredient, pyridazine, together comprise the composition 10%-80% by weight.
  • a pesticidal composition comprising a first active ingredient, etoxazole, and a second active ingredient, pyridoxine, wherein the first active ingredient, etoxazole, and the second active ingredient, pyridazine, together comprise the composition 20%-60% by weight.
  • the pesticidal composition according to the present invention further comprises a surfactant and/or a extender.
  • the insecticidal composition is in the form of an emulsifiable concentrate, a suspending agent, a seed coating agent, a water-dispersible granule, a wettable powder, a suspoemulsion, an aerosol, an aqueous emulsion, a microcapsule suspension, Microcapsule suspension-suspension, ultra-low volume liquid.
  • the present invention also provides a use of the pesticidal composition of the present invention for preventing or controlling a pest, wherein the pest is an insect or a mites.
  • the present invention also provides a method for preventing or controlling a pest, which comprises the pesticidal composition of the present invention.
  • the plant propagation material is seedlings, rhizomes, seedlings, cuttings or seeds.
  • a method for protecting crops from harmful organisms comprising cropping a mixture with a first active ingredient, etoxazole and a second active ingredient, oxazinium chlorinated insecticidal composition, a target useful plant, a target pest, or an environment thereof Contact with the reproductive material of the target useful plant.
  • a method for protecting crops from harmful organisms comprising separately, sequentially or simultaneously applying the first active component etoxazole and the second active component pyridazine.
  • the present inventors have found that combining the first active ingredient etoxazole with the second active ingredient oxazinium sulphate not only provides an additive effect on the insecticidal spectrum, but also achieves a surprising synergistic effect.
  • insecticidal effect means that the insecticidal effect of the active ingredient combination of the present invention is greater than the sum of the effects of the respective active ingredients, or that the effect is superadditive.
  • the present invention provides a pesticidal composition
  • a pesticidal composition comprising a first active ingredient etoxazole and a second active ingredient pyridaphene.
  • the present invention provides a pesticidal composition, wherein the weight ratio of the first active ingredient etoxazole to the second active ingredient pyridazine is 1:100-100:1, preferably 1:50-50:1, and further preferably 1:25-25:1, more preferably 1:10-10:1.
  • the total amount of active ingredient in the compositions of the invention can be selected based on the particular factors to achieve the desired effect.
  • the factors are, for example, a dosage form, a subject to be administered, an administration method, and the like.
  • the first active ingredient etoxazole and the second active ingredient pyridazine are in total from 5% to 90%, preferably from 10% to 80%, more preferably from 20% to 60% by weight of the composition.
  • compositions of the present invention may optionally comprise an agronomically acceptable surfactant or extender.
  • the term "filler” refers to a natural or synthetic organic or inorganic compound which may be combined or combined with the active ingredient to make it easier to apply to a subject, such as a plant, crop or grass. Therefore, the filler is preferably inert and at least agriculturally acceptable.
  • the filler may be a solid or a liquid.
  • Suitable liquid carriers can be selected from the group consisting of water, alcohols (eg methanol, ethanol, isopropanol, butanol, ethylene glycol, etc.), ketones (eg acetone, methyl ethyl ketone, diisobutyl) Ketones, cyclohexanone, etc.), ethers (such as diethyl ether, dioxane, methylcellulose, tetrahydrofuran, etc.), aliphatic hydrocarbons (such as kerosene, mineral oil, etc.), Aromatic hydrocarbons (such as benzene, toluene, xylene, mineral spirits, alkylnaphthalenes, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, chlorobenzene, etc.), halogenated hydrocarbons, amides, sulfones, dimethyl Sulfone, mineral and vegetable oils, animal oils, etc.
  • alcohols eg
  • compositions of the present invention may also comprise additional additional components such as surfactants.
  • Suitable surfactants are emulsifiers, dispersants or wetting agents having ionic or nonionic properties, or mixtures of these surfactants.
  • Suitable of these surfactants are fatty alcohol polyoxyethylene ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene higher fatty acid esters, polyoxyethylene alcohol or phenol phosphates, fatty acid esters of polyhydric alcohols, and alkane Sodium aryl sulfonate, naphthalene sulfonate polymer, lignosulfonate, polymeric comb-shaped branched copolymer, butyl naphthalene sulfonate, alkyl aryl sulfonate, sodium alkyl sulfosuccinate , polyglycerides such as fats and oils, fatty alcohols and ethylene oxide condensates, alkyl taurate salts
  • Suitable oligosaccharides or polymers are for example based on the individual ethylene monomers, acrylic acid, polyoxyethylene or polyoxypropylene or their combination with, for example, (poly)alcohols or (poly)amines.
  • a surfactant When one of the active compounds and/or one of the inert carriers is insoluble in water and when applied in water, a surfactant must be present. The proportion of surfactant is from 5% to 40% by weight of the composition of the invention.
  • the active compound can be combined with any solid or liquid additive conventionally used for formulation purposes.
  • the preparation of the present invention may be mixed with the active ingredient in a known manner by at least one of a solvent or a diluent, an emulsifier, a dispersing agent, and/or a binder or a fixing agent, and wetting.
  • the agent, the water repellent, and if necessary, may also contain a drier and a colorant, a stabilizer, a pigment, an antifoaming agent, a preservative, a thickener, water, and other processing aids.
  • the pesticidal composition of the present invention may be used as it is, or may be used in the form of its preparation or a form prepared therefrom according to its respective physical and/or chemical properties, such as an aerosol, a microcapsule suspension, a cold spray. , hot aerosol, microcapsule, fine granule, seed treatment suspension, ready-to-use solution, powder, emulsifiable concentrate, oil-in-water emulsion, water-in-oil emulsion, large granule, microparticle, oil dispersibility Powders, oil suspensions, oils, foams, pastes, seed coatings, suspensions, suspension emulsions, aqueous solvents, suspensions, wettable powders, soluble powders, powders and granules, water-soluble granules or tablets
  • the treatment of plants and plant parts with the pesticidal compositions of the present invention is carried out directly or by acting on its environment, habitat or storage area by conventional treatment methods such as dipping, watering, spraying, misting, Spreading, dusting, fogging, spreading, foaming, coating, coating, drip irrigation; in the case of propagation materials, especially in the case of seeds, powders for dry seed treatment, solutions for seed treatment, pulp
  • the material is treated in the form of a water-soluble powder, passed through a shell, coated by one or more layers, and the like.
  • compositions of the present invention include not only ready-to-use compositions that can be applied to plants or seeds by suitable means, but also commercially available concentrates that must be diluted with water prior to administration.
  • the insecticidal composition of the invention has good plant compatibility and favorable constant temperature animal toxicity, and is suitable for controlling pests encountered in agriculture, forestry, storage products and materials, and health fields, especially insects and aphids. . They are active against normally sensitive and resistant species and are active for all or a single developmental stage.
  • Coleoptera pests include, for example, sitphilusoryzaelinne, Podagricomela nigricollis Che, S. zeamails, S. granarius, Cabbageleafbeetle, and small leafhoppers. (Daikon leaf beele), fleabeetle, Altica chalybea, phyllotretastriolata, Epitrixcucumeris, Ehirtipennis, E. fuscula, Aulacophoraindica (Gemlin), Phaedon cochleariae, etc.
  • Diptera pests include, for example, agromyzaoryzae, hydrelliagriseola, liriomyzatrifolii, chromatomyiahorticola, liriomyzabryoniae, gray fly (deliaplatura), deliaantiqua, ceratitiscapiatawiedgman, rhagoletispomonella, R. cingulata.
  • Homopteran pests include, for example, nephotettixcincticeps, laodelphaxstriatellus, Rice brown planthopper (nilaparvatalugens), whitebacked planthopper (sogatella furcifera), psyllapyrisuga, diaphorinatabaci, bemisiatabaci, homoptera, and eriosomalanigerum.
  • hymenoptera there are arachinasaefifinis, argepagana, formica japonica, and dryocsmuskuriphilus.
  • Arachnida pest For example, panonychus citri, Tetranychus cinnabarinus, panonychus ulmi, tetranychus urticae, tetranychus viennensis, and small needles Oligonychus ununguis) eotetranychus kankitus, brevipalus phoenicis, bryobia praetiosa, aceria tulipae, colomerus vitis, calacarus Carinatus), polyphagotarsonemus latus, rhizoglyphus rostochiensis, and the like.
  • Isopoda for example, Oniscus asellus, Armadilliudium vulgare, Porcellio scaber.
  • Diplopoda for example, Blaniulus guttulatus.
  • Chi lopoda for example, Geophilus carpophagus Scutigera spp.
  • Thysanura for example, Lepisma saccharina.
  • Collembola for example, the armed spiny worm (Onychiurus armatus).
  • Orthoptera for example, Acheta domesticus, Gryllotalpa spp., Locusta migratoriamigrator ioides, Melanoplus pp., Desert ⁇ (Schistocercagregaria) ).
  • Dermaptera for example, Forficula auricularia.
  • Isoptera (lsoptera), for example, Reticulitermes spp.
  • All plants and plant parts can be treated in accordance with the invention.
  • the meaning of a plant herein is understood to mean all plants and plant populations, such as wild plants or crop plants (including naturally occurring crop plants) that are needed and not required.
  • Crop plants are plants obtainable by conventional breeding and preferred methods or by biotechnological and genetic engineering methods or by a combination of these methods, including plants of genetically modified plants, and plant breeders'rights. Plant varieties that are protected or not protected by them.
  • the meaning of a plant part is understood to mean all parts and organs of the plant above and below the ground, such as branches, leaves, flowers and roots, examples of which may be leaves, needles, leaves, stems, stems, flowers, fruit bodies, fruits. And seeds, as well as roots, tubers and rhizomes.
  • the plant parts also include harvested material as well as vegetative and generative propagation material such as cuttings, tubers, rhizomes, young shoots and seeds.
  • the treatment of plants and plant parts by the pesticidal composition according to the present invention is carried out by conventional treatment methods directly or by treating its environment, habitat or storage space, such as infusion, spraying, evaporation, misting, Spread and smear.
  • Wetting the plant site with the liquid composition, or treating the effective form of the solid form with the method of the present invention, or treating the target pest with the composition of the present invention may be carried out directly by a usual treatment method, or by acting It is carried out in its environment, habitat or storage area, such as by watering (impregnation), drip irrigation, spraying, evaporation, atomization, spreading, dusting, foaming, coating, etc. Foliar application), the frequency and amount of application can be adjusted to the extent that it is infested by the pest.
  • the soil or cultivation medium of the plant when carried out according to the method of use of the present invention means that the crop can be rooted
  • the support body to be grown for example, soil, water, etc., may be, for example, sand, pumice, vermiculite, diatomaceous earth, agar, gel, high molecular material, asbestos, wood chips, bark, or the like.
  • a method of applying a medicament to the soil for example, diluting the liquid medicament in water or undiluting the root applied directly to the root of the plant or the method of growing the farm, and spreading the granule into the root of the plant or in the field of the nursery
  • powder, water-dispersible granules, etc. are sprayed into the soil and mixed with the soil as a whole.
  • the powder and the water-dispersible granules are diluted and sprayed in the planting hole and the seeding ditch. The method of sowing, etc.
  • compositions of the invention are also suitable for protecting plant propagation material such as seeds, fruits, tubers or nucleoli or plant cuttings from pests, particularly insects and mites.
  • the propagation material can be treated with the composition prior to application, such as seed dressing prior to sowing.
  • the active ingredient can also be applied to the seed (coating) by soaking the nucleoli in the liquid composition or coating the nucleolus with a solid composition.
  • the composition can also be applied to the application site when the propagation material is applied, for example, within the seed ditch during sowing.
  • the treatment of the present invention may also produce a super-additive effect of improving plant growth, increasing tolerance to high or low temperatures, increasing tolerance to drought or salinity to water or soil, and increasing flowering. Quality, ease of harvesting, accelerated maturity, improved harvesting yield, improved quality of harvested products and/or improved nutritional value, improved storage stability of harvested products and/or their processing properties.
  • the dose can even be reduced, in particular when applying an inert matrix When it is asbestos or pearl rock;
  • the pesticidal composition of the present invention comprises the separate, sequential or simultaneous administration of the first active ingredient etoxazole and the second active ingredient.
  • any of the technical features of any embodiment or embodiment of the present invention may be independently combined with any other embodiment of the present invention. That is, one or more of the technical features of any of the embodiments of the present invention can be recombined with any other technical features. Technical features formed by recombining such technical features are disclosed herein, as specifically recited herein.
  • insecticidal activity exceeds the sum of the activities of the two active compounds when applied; this makes it possible to optimize the amount of active compound used;
  • Example 1 emulsifiable concentrate
  • Second active ingredient pyridaphene 3% N-methylpyrrolidone 20% Ethoxylated castor oil 4% Fatty alcohol polyoxyethylene ether sulfosuccinate monosodium disodium 10 SOLVESSO TM 200 Make up to 100%
  • Example 2 wettable powder
  • Second active ingredient etoxazole 10%
  • Second active ingredient pyridaphene 10%
  • White carbon black 10% Kaolin Make up to 100%
  • Second active ingredient etoxazole 10%
  • Second active ingredient pyridaphene 2% N-methylpyrrolidone 15%
  • Sodium dodecyl benzene sulfonate 5%
  • Phenylethyl phenol polyoxyethylene ether 5% water
  • the original drug, the solvent and the emulsifier are added together to dissolve into a uniform oil phase; the water-soluble component and water are mixed to prepare an aqueous phase; and the oil phase is mixed with the water phase under high-speed stirring to obtain the present invention.
  • Water emulsion Water emulsion.
  • the active ingredient, the dispersing agent, the wetting agent, the disintegrating agent and the filler are uniformly mixed according to the formulation ratio, and are pulverized into a wettable powder by a jet stream, and then added with a certain amount of water to be mixed and granulated.
  • the water-dispersible granules of the present invention are obtained by dry sieving.
  • Example 6 wettable powder
  • Second active ingredient pyridaphene 1% Sodium dodecyl sulfate 10% Sodium lignosulfonate 15% White carbon black 10% Kaolin Make up to 100%
  • the above components of calcium lignosulfonate, xanthan gum, bentonite, glycerin, water, etc. are uniformly mixed in proportion and sand-milled to prepare a suspension.
  • An oil phase containing the first active ingredient etoxazole is added to a suspension containing the second active ingredient pyridaphenthione to obtain a suspoemulsion.
  • Second active ingredient pyridaphene 10% Methyl oleate 10% Polystyrene 3.7%
  • Dissolving the first active ingredient etoxazole and the second active ingredient pyridazine in methyl oleate adding polystyrene to obtain an oil phase; mixing the components according to the components in the formulation to obtain an aqueous phase; and stirring the oil The phase is added to the aqueous phase to obtain an aqueous emulsion.
  • Example 9 wettable powder
  • Second active ingredient pyridaphene 20% Sodium lignosulfonate 7% Sodium lauryl sulfate 2% Kaolin Make up to 100%
  • the above combinations are mixed in proportion, ground, and pulverized to prepare a wettable powder.
  • Second active ingredient pyridaphene 50% Polyethylene glycol 3% Highly dispersed silicic acid 1% Calcium carbonate Make up to 100%
  • the milled active ingredient is uniformly applied to the carrier wetted with polyethylene glycol in a mixer. In this way, dust can be obtained Coated granules.
  • Second active ingredient pyridaphene 25% Sodium lignosulfonate 10% Sodium dodecyl sulfate 3% White carbon black 5% Kaolin Make up to 100%
  • the above components are mixed in proportion, ground and pulverized to prepare a wettable powder.
  • Second active ingredient pyridaphene 50% Sodium lignosulfonate 4% Carboxymethyl cellulose 2% White carbon black 5% Kaolin Make up to 100%
  • the active ingredient is mixed with the auxiliaries and ground and the mixture is moistened with water.
  • the mixture was extruded and then dried in a stream of air.
  • the modified components such as calcium lignosulfonate, xanthan gum, bentonite, glycerin, water, etc. are uniformly mixed in proportion and sand-milled to prepare a suspension.
  • An oil phase containing the second active ingredient pyridaphene is added to a suspension containing the first active ingredient etoxazole to obtain a suspoemulsion.
  • An oil phase containing the second active ingredient pyridaphene is added to a suspension containing the first active ingredient etoxazole to obtain a suspoemulsion.
  • the acid monoester disodium, the modified lignosulfonate calcium, the xanthan gum, the bentonite, the glycerin, the water and the like are uniformly mixed in proportion and sand-milled to prepare a suspension.
  • An oil phase containing the second active ingredient pyridaphene is added to a suspension containing the first active ingredient etoxazole to obtain a suspoemulsion.
  • Example 16 emulsifiable concentrate
  • Second active ingredient etoxazole 5%
  • Second active ingredient pyridaphene 15% N-methylpyrrolidone 20%
  • Ethoxylated castor oil 4%
  • Fatty alcohol polyoxyethylene ether sulfosuccinate monosodium disodium 10 SOLVESSO TM 200 make up to 100%
  • the above components are mixed and stirred to a uniformly transparent liquid to obtain the emulsifiable concentrate of the present invention.
  • microcapsule containing the second active ingredient pyridaphenthione is added to the aqueous suspension of the first active ingredient etoxazole, and stirred uniformly to obtain the microcapsule suspension-suspending agent of the present invention.
  • Second active ingredient pyridaphene 50% SOLVESSO TM 200 20% Ethoxylated castor oil 5% Fatty alcohol polyoxyethylene ether sulfosuccinate monosodium disodium 10% Modified sodium lignosulfonate 5% Xanthan gum 0.5% Glycerol 5% Polyvinylpyrrolidone (PVP-K30) 1% Defoamer 0.6% water make up to 100%
  • the above components are uniformly mixed in proportion and sanded to prepare a suspension Agent.
  • the oil phase containing the second active ingredient oxazinium is added to the suspension seed coating containing the first active ingredient etoxazole to obtain the suspension seed coating of the present invention.
  • Second active ingredient etoxazole 5%
  • Second active ingredient pyridaphene 5%
  • Propylene glycol 5%
  • Phosphate 3.5%
  • Ethoxylated castor oil 20% SOLVESSO TM 100
  • the antifreeze propylene glycol, the diluent SOLVESSO TM 100 is mixed, and the first active ingredient etoxazole and the second active ingredient pyridazine are added under stirring; the surfactant is added thereto, and the mixture is stirred by a pulverizing equipment colloid mill. After pulverization, the colloid-milled suspension is passed through an ultrafine pulverizer. The cycle is repeated until the particle diameter of the solid particles is ⁇ 2 um.
  • Example 20 wettable powder
  • Second active ingredient etoxazole 50% Second active ingredient pyridaphene 5% Sodium dodecyl sulfate 1% Sodium lignosulfonate 1% White carbon black 1% Kaolin Make up to 100%
  • the wettable powder of the present invention is obtained by mixing the active ingredients, various auxiliaries, fillers and the like in proportions of the formulation and pulverizing them by an ultrafine pulverizer.
  • the first active ingredient etoxazole and the second active ingredient pyridazine are uniformly mixed according to the ratio.
  • the ratio in the above embodiment is a weight ratio of one hundred.
  • the inventors conducted a large number of tests and effect analysis on the different ratios of etoxazole and oxazinone through a large number of screening tests, and found that the insecticidal composition obtained has a gain effect within a certain ratio range. Rather than simply adding the two agents, the following embodiments are specifically described.
  • a combination of indoor virulence determination and insecticidal test is adopted, firstly, the indoor toxicity test is used to determine the co-toxicity coefficient (CTC) of the two agents after being compounded in a certain ratio, and CTC ⁇ 80 is resistant.
  • CTC co-toxicity coefficient
  • Mortality (%) (number of live insects before drug - number of live insects) / number of live insects before drug *100
  • Measured virulence index (ATI) (standard drug LC 50 / test agent LC 50 ) ⁇ 100
  • Test 1 Determination of indoor virulence of Diptera
  • the test was carried out with reference to the pesticide bioassay test guidelines for pesticides (agricultural industry standard NY/T1154.7-2006) and the creation of pesticide bioactivity evaluation SOP (insecticide rolls) using the impregnation method. Cut the leaves of the bean leaves with the handle and insert them into the ampoules with water. Receive a certain number of members. After 24 hours of spawning, remove the mites, immerse the leaves with enough eggs in the liquid for 10 s, quickly absorb the excess liquid with absorbent paper, place the leaves in the ampoules, and dry naturally. . Place in the observation room for cultivation. The test was repeated 4 times, and a blank control was set up, and the whole of the control was investigated after incubation. At the time of the investigation, the young babies who could not hatch and could not crawl normally were regarded as dead insects.
  • Test 2 Results of indoor virulence test for citrus catfish
  • the leaves of the same size that are not in contact with any agent are soaked in the prepared liquid for 5s. After taking out, naturally drying, placed in the worm box, and then attached to the test larvae, raised at 25 ° C, each treatment 3 times repeated, the number of test insects used per repetition is 20, while setting a blank control, The number of dead insects was checked at 72h, the mortality and corrected mortality were calculated, and the virulence regression equation was calculated and the LC50 value was calculated. If the control mortality is greater than 10%, it is considered an invalid test.
  • X is the kill rate when active compound A is used in an amount of m g/ha or at a concentration of m ppm, expressed as a percentage of the untreated control
  • Y is the kill rate when using the active compound B in an amount of n g/ha or a concentration of n ppm, expressed as a percentage of the untreated control
  • E is the killing rate when active ingredients A and B are used in amounts of m and n g/ha or at concentrations of m and n ppm, expressed as a percentage of the untreated control,
  • the lethal effect of the composition is superadditive, i.e., there is a synergistic effect.
  • the actually observed kill rate must exceed the value of the expected kill rate value (E) calculated using the above formula.
  • the test was carried out as follows: The test site was in Jiaxing, Zhejiang, and the time was early May. The potted citrus test was carried out for 3 years. Before the spraying, each plant was inoculated with 200 whole females. Spray treatment 2 days after inoculation. According to the front and back of the wetted leaves, 3 citrus seedlings were treated each. On the 3rd, 10th, 20th, and 30th days after the drug, 25 leaves were taken in the laboratory to investigate the number of mites on the leaves with binoculars, and the reduction rate and control effect were calculated. The formula is as follows:
  • Mouth reduction rate (%) (number of live insects in the treatment area - number of live insects in the treatment area) / number of live insects in the treatment area *100
  • Control effect (%) (treatment area mouth drop rate ⁇ control area mouth drop rate) / (100 ⁇ control area mouth drop rate) * 100
  • Test 2 Efficacy test of citrus aphid
  • the test was carried out as follows: The test site was in Jiaxing, Zhejiang, and the time was in early March. The potted citrus test was carried out for 3 years. Before the spraying, 200 insects were inoculated with cotton aphid. Spray treatment 2 days after inoculation. According to the front and back of the wetted leaves, 3 citrus seedlings were treated each. Six days after the drug, 25 leaves were taken in the laboratory to investigate the number of adults on the leaves with binoculars, and the population reduction rate and control effect were calculated. The formula is as follows:
  • Infestation rate (%) (number of live insects in the treatment area - number of live insects in the treatment area) / number of live insects in the treatment area *100
  • Control effect (%) (reduction rate of insects in the treatment area ⁇ reduction rate of insects in the control area) / (100 ⁇ reduction rate of insects in the control area) *100

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本发明涉及的是一种杀虫剂组合物，包括第一活性成分乙螨唑和第二活性成分哒嗪硫磷，尤其涉及杀虫方法。本发明提供一种杀虫组合物，包括乙螨唑和哒嗪硫磷，所述乙螨唑与哒嗪硫磷的重量比为1:100-100:1。所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷总共占所述组合物以重量计的5％-90％。所述杀虫组合物具有更好的速效性和持效性，在杀虫效果上具有协同增益的效果，同时可降低生产成本和农用成本，更好地服务于农业生产。

Description

杀虫组合物 技术领域
本发明涉及的是一种杀虫剂组合物，包括第一活性成分乙螨唑和第二活性成分哒嗪硫磷，尤其涉及杀虫方法。
背景技术
乙螨唑(Etoxazole)是日本住友化学研究开发的一个全新的具有独特结构的化合物。其化学名称为：(RS)-5-叔丁基-2-[2-(2,6-二氟苯基)-4,5-二氢-1,3-噁唑-4-基]苯乙醚，其分子结构式为式(I)：
Figure PCTCN2015073287-appb-000001
乙螨唑对叶螨、始叶螨和全爪螨，如二斑叶螨、朱砂叶螨、柑橘红蜘蛛、山楂、葡萄叶螨等具有卓越防效。其作用方式包括抑制正常的蜕皮过程和杀卵活性，因此能有效地防治害螨的整个幼龄期(卵、幼螨和若螨)。另外虽然乙螨唑不能直接杀死成螨，但是对雌性成螨具有很好的不育作用。能防治对现有杀螨剂已经产生抗性的螨类害虫。乙螨唑具有较强的耐雨性和较长的持效性。正确使用时在果树上的持效期可以达到50天以上，在棉花、蔬菜和观赏植物上的持效期可以达到30天以上。到目前为止，对乙螨唑在温室及田间进行的试验浓度中未曾观察到由其造成的药害现象。对许多有益昆虫和益螨危害极小甚至无危害。乙螨唑是有害生物综合治理系统中的重要成员。
哒嗪硫磷，化学名称叫O，O-二乙基-O[2，3-二氢-3-氧代-2-苯基-6-哒嗪基]硫代磷酸酯，其结构式为式(II)：
Figure PCTCN2015073287-appb-000002
哒嗪硫磷对多种咀嚼式口器和刺吸式口器害虫均有较好效果。使用方法为乳油对水喷雾或粉剂喷粉。此药剂对水稻害虫药效突出，对水稻害虫的天敌捕食螨较安全，对鱼类低毒，在稻 谷中残留量低，特别适合用于水稻，可防治螟虫、纵卷叶螟、稻苞虫、飞虱、叶蝉、蓟马、稻瘿蚊等。对棉叶螨特效，对成蟥、若螨、螨卵都有显著抑制作用，还可防治棉蚜、棉铃虫、红铃虫。用于小麦、杂粮、油料、蔬菜、果树等作物及林木，可治愈治多种咀嚼式口器、刺吸式口器害虫及叶螨。哒嗪硫磷属低毒低残留广谱性有机磷类杀虫杀螨剂，对害虫、害螨具有触杀和胃毒作用,且有一定杀卵作用。具有良好的速效性，同时具有低毒、低残留、不易诱发害虫抗药性等特点。
螨类俗称红蜘蛛，属蛛形纲害虫，是为害果树、棉花、茄科、蔬菜和观赏花卉等多种作物的重要害虫之一，常见的害螨多属于真螨目和蜱螨目。螨类主要为害植物的叶、茎和花等，刺吸植物的茎叶，初期叶正面有大量针尖大小失绿的黄褐色小点，后期叶片从下往上开始失绿卷缩、甚至脱落。有时从植株中部叶片开始发生，叶片逐渐变黄、脱落。害螨发生世代多，繁殖能力强，在适宜的温湿度条件下，能在较短时间内螨虫数量能迅速成倍增长，给农作物造成很大危害。害螨对杀螨药剂易产生抗药性，如果在严重发生时未及时防治，受害作物的叶片会失绿发白，提前凋落。在热带及温室条件下，全年都可发生。温度的高低决定了螨类各虫态的发育周期、繁殖速度和产卵量的多少。干旱炎热的气候条件往往会导致其大发生。
由于螨类发生量大，繁殖周期短，隐蔽，抗性上升快，难以防治，所以使用化学农药制剂仍然是防治农业生产上螨害的主要方法。
现如今，哒嗪硫磷均已作为农业上的杀螨剂在使用，在螨类发生初期单独使用哒嗪硫磷可有效抑制螨类数量上升，速效性较好，但当螨类已大量发生时，随着时间的推移哒嗪硫磷便逐渐控制不住其数量，使得持效期不超过20天，一次用药只能起到控制一代螨害的效果。
乙螨唑具有持效期长的特点，所以适用时期宽，但其对成螨无效，对柑柑、棉花、梨及蔬菜上的红蜘蛛的起效时间为药后7-10天才达到死亡高峰，至使叶片因红蜘蛛的危害而失绿，但其持效期可达30-45天。
所述单独化合物的活性良好；然而，在低施用率或针对单独的害虫使用时它们不是总能满足杀昆虫剂、杀螨剂或杀线虫剂所必须满足的高要求。
在害虫防治领域出现的一个典型的需求是需要降低防治活性成分的剂量率以及降低或避免不利的环境或毒理学影响，同时仍允许有效的害虫防治。还需要结合了击倒活性和延长防治时间，即快速作用和长效作用的害虫防治剂。
使用杀虫剂的另一个难处在于重复和唯一地使用单一杀虫化合物在许多情况下导致对所述活性化合物产生天然或适应抗药性的害虫的快速选择。因此，需要有助于防止或克服抗药性的害虫防治剂。
因此，本发明的一个目的是提供解决了所述问题中的至少一个，如降低剂量率、扩大活 性谱或结合击倒活性和延长防治时间或抗药性管理的杀虫组合物，延缓抗性。
发明内容
为了解决上述技术问题，本发明提供了一种杀虫剂组合物，该组合物通过将乙螨唑和哒嗪硫磷进行组合，使得得到的组合物在防治效果上具有增益效果，并且拓展了杀虫谱，提高了害虫防治的快速作用和长效作用，延缓了抗药性的产生。
本发明解决其技术问题所采用的技术方案为：
一种杀虫组合物，包括
第一活性成分乙螨唑，
第二活性成分哒嗪硫磷；
所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷按重量配比为1:100-100:1。
作为本发明的进一步改进，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷按重量配比是1:50-50:1。
作为本发明的进一步改进，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷按重量配比是1:25-25:1。
作为本发明的进一步改进，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷按重量配比是1:10-10:1。
一种杀虫组合物，包括第一活性成分乙螨唑和第二活性成分哒嗪硫磷，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷的重量总共占所述组合物以重量计的5％-90％。
一种杀虫组合物，包括第一活性成分乙螨唑和第二活性成分哒嗪硫磷，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷共占所述组合物以重量计的10％-80％。
一种杀虫组合物，包括第一活性成分乙螨唑和第二活性成分哒嗪硫磷，所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷总共占所述组合物以重量计的20％-60％。
根据本发明的杀虫组合物，还包含表面活性剂和/或增充剂。
根据本发明的杀虫组合物，所述杀虫组合物可配制成农业上允许的任意剂型。
根据本发明的杀虫组合物，所述杀虫组合物的剂型为乳油、悬浮剂、种衣剂、水分散粒剂、可湿性粉剂、悬乳剂、烟雾剂、水乳剂、微囊悬浮剂、微囊悬浮-悬浮剂、超低容量液剂。
另一方面，本发明还提供了一种将本发明的杀虫组合物用于预防或控制有害生物的用途，其中有害生物为昆虫、螨虫。
优选的，所述杀虫组合物用于防治红蜘蛛和蚜虫的用途。
另一方面，本发明还提供了一种预防或控制有害生物的方法，将本发明的杀虫组合物作 用于目标有用植物、目标有害生物或其环境、目标有用植物的繁殖材料。所述植物繁殖材料是籽苗、根茎、圃苗、插条或种子。
一种保护作物以防有害生物侵袭的方法，包括使作物与含第一活性组分乙螨唑和第二活性组分哒嗪硫磷杀虫组合物与目标有用植物、目标有害生物或其环境、目标有用植物的繁殖材料接触。
一种保护作物以防有害生物侵袭的方法，包括分开、依次或同时施用第一活性组分乙螨唑、第二活性组分哒嗪硫磷。
本发明发现：将第一活性成分乙螨唑和第二活性成分哒嗪硫磷组合不仅可带来对于杀虫谱的加和性提高，而且还实现令人惊喜的协同作用。
本文中使用的术语“协同作用”指本发明活性成分组合杀虫效果大于各活性成分效果之和，或者说，其作用是超加和性的。
本发明提供了一种包含第一活性成分乙螨唑和第二活性成分哒嗪硫磷的杀虫组合物。
本发明提供了一种杀虫组合物，其中第一活性成分乙螨唑和第二活性成分哒嗪硫磷重量比为1:100-100:1，优选1:50-50:1，再优选1:25-25:1，更优选1:10-10:1。
本发明组合物中活性成分的总量可根据具体因素而进行选择，以实现所期望的作用。所述因素例如，剂型、待施用对象、施用方法等。第一活性成分乙螨唑和第二活性成分哒嗪硫磷总共占所述组合物以重量计的5％到90％，优选10％到80％，更优选20％到60％。
本发明的组合物可任选地包含农学上可接受的表面活性剂或增充剂。
根据本发明，术语“填充剂”指可与活性成分相组合或联合以使其更易于施用给对象(例如植物、作物或草类)的天然或合成的有机或无机化合物。因此，所述填充剂优选为惰性的，至少应为农业可接受的。所述填充剂可以为固体或液体。
适用的固体载体为：例如植物质粉末类(例如大豆粉、淀粉、谷物粉、木粉、树皮粉、锯末、核桃壳粉、麸皮、纤维素粉末、椰壳、玉米穗轴和烟草茎的颗粒，提取植物精华后的残渣等)、黏土类(例如高岭土、皂土、酸性瓷土等)、滑石粉类。硅石类(例如硅藻土、硅砂、云母、含水硅酸，硅酸钙)、活性炭、天然矿物质类(浮石、绿坡缕石及沸石等)、烧制硅藻土、砂、塑料媒介等(例如聚乙烯、聚丙烯、聚偏二氯乙烯等)、氯化钾、碳酸钙、磷酸钙等的无机矿物性粉末、硫酸铵、磷酸铵、尿素、绿化铵等的化学肥料、土肥，这些物质可以单独使用或者2种以上混用。
适用的液体载体可以在下列材料中选择，例如水，酒精类(例如甲醇、乙醇、异丙醇、丁醇、乙二醇等)、酮类(例如丙酮、甲基乙基酮、二异丁基甲酮、环己酮等)、醚类(例如乙醚、二恶烷、甲基纤维素、四氢呋喃等)、脂肪族碳氢化合物类(例如煤油、矿物油等)、 芳香族碳氢化合物类(例如苯、甲苯、二甲苯、溶剂油、烷基萘、氯代芳烃、氯代脂肪烃、氯苯等)、卤化碳氢化合物类、酰胺类、砜类、二甲基亚砜、矿物和植物油、动物油等。
本发明的组合物还可包含附加的其他组分，例如表面活性剂。适用的表面活性剂有具有离子或非离子性质的乳化剂、分散剂或润湿剂，或这些表面活性剂的混合物。这些表面活性剂的适合的有脂肪醇聚氧乙烯醚、聚氧乙烯烷基芳基醚、聚氧乙烯高级脂肪酸酯、聚氧乙烯醇或酚的磷酸酯、多元醇的脂肪酸酯、烷芳基磺酸钠、萘磺酸聚合物、木质素磺酸盐、高分子梳形的支装共聚物、丁基萘磺酸盐、烷基芳基磺酸盐、烷基磺基琥珀酸钠、油脂、脂肪醇与环氧乙烷缩合物、烷基牛磺酸盐等聚丙烯酸盐、蛋白质水解物。合适的低聚糖物或聚合物，例如基于单独的乙烯单体、丙烯酸、聚氧乙烯或聚氧丙烯或者其与例如(多元)醇或(多元)胺的结合。当活性化合物中的一种和/或惰性载体中的一种不溶于水且当在水中施用时，必须存在表面活性剂。表面活性剂的比例为本发明的组合物的5％至40％重量。
如果合适，也可以存在其他添加组分，例如保护胶体、粘合剂、胶粘剂、增稠剂、触变剂、渗透剂、稳定剂、掩蔽剂、多价螯合剂、络合物形成剂。通常，所述的活性化合物可以与常规用于制剂目的的任何固体或液体添加剂结合。
本发明的所述制剂可通过已知方式将所述活性成分与以下物质中的至少一种进行混合：溶剂或稀释剂、乳化剂、分散剂、和/或粘合剂或固定剂、润湿剂、防水剂，如果需要，还可以包含催干剂和着色剂、稳定剂、颜料、消泡剂、防腐剂、增稠剂、水以及其它加工助剂。
本发明的杀虫组合物可以其本身使用，或者可根据其各自的物理和/或化学性质以其制剂形式或由其制备的使用形式使用，例如气雾剂、微胶囊悬浮剂、冷雾剂、热雾剂、微囊粒剂、细粒剂、种子处理用悬浮剂、即用溶液剂、粉剂、乳油、水包油型乳剂、油包水型乳剂、大粒剂、微粒剂、油分散性粉剂、油悬剂、油剂、泡沫剂、糊剂、种衣剂、胶悬剂、悬浮乳剂、水溶剂、悬浮剂、可湿性粉剂、可溶性粉剂、粉剂和颗粒剂、水溶性颗粒剂或片剂、种子处理用水溶性粉剂、可湿性粉剂、活性化合物浸渍的天然产品及合成物质、聚合材料中与种子包覆物质中的微囊剂，以及超低容量冷雾剂及热雾制剂。
用本发明杀虫组合物对植物及植物部分的处理以常规处理方法直接进行或通过作用于其环境、生境或贮存区域而进行，所述常规处理方法例如浸渍、进行浇灌、喷雾、弥雾、撒播、喷粉，成雾、撒播、发泡、涂覆、涂布、滴灌；在繁殖材料的情况下,尤其在种子的情况下，用于干种子处理的粉剂、种子处理用溶液剂、浆料处理用水溶性粉末形式，通过结壳、通过一层或多层包衣等。
本发明的组合物不仅包括可用合适的装置施用于植物或种子的即用组合物，而且包括在施用之前必须用水稀释的市售浓缩液。
本发明的组合物还可以与其它活性成分联合施用，所述其它活性成分例如杀真菌剂、杀细菌剂、引诱剂、杀昆虫剂、杀螨剂、杀线虫剂、生长调节剂、除草剂、安全剂、肥料或化学信息素等。
本发明的杀虫组合物，具有良好的植物相容性和有利的恒温动物毒性，适于防治在农业、林业、保护储藏产品和材料以及卫生领域中遇到的有害生物，尤其是昆虫和螨虫。它们对于通常敏感和抗性的物种具有活性，并且对于所有或单个发育阶段均具有活性。
本文中使用术语“有害生物”意指可对植物的正常状态造成损失的任何有机体。包括：鳞翅目害虫包括例如：二化螟(chilosuppressalis(walker)、三化螟(Tryporyzaincertulas(walker))、稻纵卷叶螟(cnaphalocrocismedinalisGuenee)、菜心螟(hellullaundalis)、桃蛀螟(conogethespunctiferlis)、柑桔凤蝶(papilioxuthus)、白粉蝶(pierisrapaecrucivora)、直纹稻弄蝶(parnaraguttata)、天幕毛虫(malacosoma Neustria testacea)、舞毒蛾(lymantriadispar)、美国白蛾(hyphantriacunea)、东方毒蛾(euproctissubflava)、黑纹刺蛾(scopelodescontracus)、棉铃虫(helicoverpaarmigera)、红铃麦蛾(Pink bollworm)、粉纹夜蛾(trichoplusiani)、甘蓝夜蛾(mamestrabrassicae)、甜菜夜蛾(spodopteraexigua)、斜纹夜蛾(spodopteralitura)、茶小卷叶蛾(adoxophyesoranafasciata)、卷叶蛾(adoxophyeshonmai)、杏黄卷蛾(archipsfuscocureanus)、茶长卷蛾(homonamagnanima)、小菜蛾(plutellaxylotella)、棉红铃虫(pectinophoragossypiella)。
鞘翅目害虫包括例如：米象(sitophilusoryzaelinne)、柑橘潜叶甲(Podagricomela nigricollis Che)、玉米象(S.zeamails)、谷象(S.granarius)、大猿叶虫(Cabbageleafbeetle)、小猿叶虫(Daikon leaf beele)，跳甲(fleabeetle)、葡萄跳甲(Alticachalybea)、曲条跳甲(phyllotretastriolata)、黄瓜跳甲(Epitrixcucumeris)、烟草跳甲(Ehirtipennis)、茄跳甲(E.fuscula)、黄守瓜(Aulacophoraindica(Gemlin)、芥菜叶甲(Phaedon cochleariae)等。
双翅目害虫包括例如：稻潜蝇(agromyzaoryzae)、大麦水蝇(hydrelliagriseola)、非洲菊斑潜蝇(liriomyzatrifolii)、豌豆叶潜蝇(chromatomyiahorticola)、番茄斑潜蝇(liriomyzabryoniae)、灰地种蝇(deliaplatura)、葱地种蝇(deliaantiqua)地中海实蝇(ceratitiscapiatawiedgman)、苹果实蝇(Rhagoletispomonella)、樱桃实蝇(R.cingulata)。
半翅目害虫包括例如：臭蝽(megacoptapunctatissimum)、菜蝽(eurydemarugosum)、大刺白星蝽(eysarcorislewisi)、白星蝽(eysarcorisparvus)、稻绿蝽(nezaraviridula)、斯氏珀蝽(plautiastali)、臭梧桐蝽(halymorphamista)、稻棘缘蝽(cletuspunctiger)、中华稻缘蝽(leptocorisachinensis)、杜鹃网蝽(stephantispyrioides)、赤须盲蝽(trigonotyluscoelestialium)。
同翅目害虫包括例如黑尾叶蝉(nephotettixcincticeps)、灰飞虱(laodelphaxstriatellus)、 稻褐飞虱(nilaparvatalugens)、白背飞虱(sogatellafurcifera)、梨木虱(psyllapyrisuga)、柑橘木虱(diaphorinatabaci)、烟粉虱(bemisiatabaci)、蚜虫(homoptera)、苹果棉蚜(eriosomalanigerum)。
膜翅目(hymenoptera)中有，黄翅菜叶蜂(athaliarosaeruficornis)、蔷薇叶蜂(argepagana)、黑山蚁(formica japonica)、栗瘿蜂(dryocsmuskuriphilus)等。
缨翅目害虫，例如蓟马(HaplothripsChinensisPriesner)。
蛛形纲(Arachnida)的害虫。例如柑橘全爪螨(panonychus citri)、朱砂叶螨(Tetranychus cinnabarinus)、苹果全爪螨(panonychus ulmi)、二点叶螨(tetranychus urticae)、山楂叶螨(tetranychus viennensis)、针叶小爪螨(oligonychus ununguis)柑橘始叶螨(eotetranychus kankitus)、紫红短须螨(brevipalpus phoenicis)、苜蓿苔螨(bryobiapraetiosa)、小麦卷叶螨(aceria tulipae)、葡萄瘿螨(colomerus vitis)、茶叶瘿螨(calacarus carinatus)、茶黄螨(polyphagotarsonemus latus)、长毛根螨(rhizoglyphus rostochiensis)等。
虱目(Anoplura,Phthiraptera)，例如畜虱属(Damalinia spp.)、血虱属(Haematopinus spp.)、毛虱属(Linognathus spp.)、虱属(Pediculus spp.)、嚼虱属(Trichodectes spp.)。
等足目(Isopoda)，例如，栀水虱(Oniscus asellus)、鼠妇(Armadilliudium vulgare)、球鼠妇(Porcellio scaber)。
倍足目(Diplopoda)，例如，Blaniulus guttulatus。
唇足目(Chi lopoda)，例如，地蜈蚣属(Geophilus carpophagusScutigera spp.)。
综合目(Symphyla)，例如，白松虫(Scutigerella immaculata)。
缨尾目(Thysanura)，例如，衣鱼(Lepisma saccharina)。
弹尾目(Collembola)，例如，武装棘跳虫(Onychiurus armatus)。
直翅目(Orthoptera)，例如，家蟋(Acheta domesticus)、喽蛄属属种(Gryllotalpa spp.)、亚洲飞蝗(Locusta migratoriamigrator ioides)、黑蝗属种(Melanopluss pp.)、沙漠蝗(Schistocercagregaria)。
蜚蠊目(Blattaria)，例如，东方蜚蠊(Blattaorientalis)、美洲大蠊(Periplaneta americana)、马德拉蜚蠊(Leucophaea maderae)、德国小蠊(Blattella germanica)。
革翅目(Dermaptera)，例如，欧洲球螋(Forficula auricularia)。
等翅目(lsoptera)，例如，散白蚁属种(Reticulitermes spp.)。
线虫纲((Nematoda))的代表性生物有选自根结线虫、胞囊形成线虫、秆线虫和叶线虫的线虫。优选下列线虫的大豆胞囊线虫(Heterodera),马铃薯金线虫(golbodera rostochiensis)、南方根结线虫(meloidogyne incognita)等、矛线目(dorylaimida)中有，长针线虫属(longidorus  sp.)等。
本发明的杀虫组合物对于防治蚜虫和红蜘蛛有突出的效果。
所有植物和植物部位都可根据本发明处理。本文中的植物的含义应理解为所有植物和植物群体，如需要和不需要的野生植物或作物植物(包括天然存在的作物植物)。作物植物为可通过常规育种和优选方法或可通过生物技术和遗传工程方法或可通过这些方法的组合获得的植物，所述植物包括转基因植物，也包括可受植物育种者权(plant breeders'rights)保护或不受其保护的植物品种。植物部位的含义应理解为所述植物全部地上和地下的部分和器官，如枝条、叶、花和根，可提及的实例为叶、针、叶、茎、干、花、子实体、果实和种子，以及根、块茎和根茎。所述植物部位也包括采收物以及无性与有性繁殖物，如插枝、块茎、根茎、幼枝和种子。
需强调的是本发明的杀虫组合物用于例如以下植物时特别有利的效果：谷类植物如小麦、燕麦、大麦、斯佩耳特小麦(spelt)、黑小麦和黑麦，以及玉米、高梁和栗、稻、甘蔗、大豆、向日葵、马铃薯、棉花、油菜(oil seed rape)、加拿大油菜(canola)、烟草、甜菜、饲用甜菜、芦笋、啤酒花和果实植物(包括梨果如苹果和梨，核果如桃、蜜桃、樱桃、李子、杏，柑桔类水果如橙子、葡萄柏、酸橙、拧禄、金桔、柑橘和萨摩蜜橘，坚果如阿月浑子、扁桃、核桃和美洲山核桃，热带水果如芒果、番木瓜、菠萝、海枣和香蕉，和葡萄)和蔬菜(包括叶菜类如苦苣、野苣、茴香、叶用莴苣、直立莴苣、瑞士甜菜、菠菜及沙拉用菊苣，甘蓝如花椰菜、青花椰菜、生菜叶、Brassica oleracea(L.)convar.acephalavar.sabellicaL.(皱叶甘蓝、羽衣甘蓝)、球茎甘蓝、抱子甘蓝、红球甘蓝、白球甘蓝和皱叶甘蓝，果菜类如茄子、黄瓜、辣椒、食用南瓜、番茄、密生西葫芦和甜玉米，根菜类如块根芹、油菜、胡萝卜包括黄色品种、野生萝卜类包括Raphanus sativus var.niger和Raphanus sativus var.radicula、甜菜、芹菜，豆科植物如豌豆和大豆，以及葱属蔬菜如韭菜和洋葱)。
根据本发明的杀虫组合物对植物和植物部位的处理，通过常规处理方法直接进行或者处理其环境、生境或储存空间来进行，所述常规处理方法例如浸液、喷雾、蒸发、弥雾、撒播、涂抹。
用液体组合物浸湿植物所在地点、或将固体形式的有效成用本发明的方法处理目标有用生物，或者用本发明的组合物处理目标有害生物，可以通过通常处理方法直接进行，或者通过作用于其环境，生境或贮存区域而进行，所述通常处理方法如通过浇灌(浸渍)、滴灌、喷雾、蒸发、雾化、撒播、撒粉、发泡、涂布等方式向植物的叶片施用(叶面施用)，可以调节施用的频率和用量，使其适应被所述有害生物侵害的程度。
按本发明的使用方法进行实施时所说的植物的土壤或栽培媒介是指能够使农作物生根、 生长的支撑体，例如：土壤，水等，具体的原材料可以使用例如砂子、浮石、蛭石、硅藻土、琼胶、凝胶状物、高分子物质、石棉、木屑、树皮等。
向土壤中施用药剂的方法，例如将液体药剂稀释于水中或不稀释直接施用于植物体的根部或育秧用的秧田中等方法，将颗粒剂散播到植物体的根部或者育秧的秧田中的方法有在播种前将粉剂、水分散粒剂等喷洒于土壤中并与土壤整体混合的方法，播种前或栽种植物体前将粉剂、水分散粒剂稀释后喷洒于种植孔、播种沟中，在进行播种的方法等。
本发明的组合物也适合于保护植物的繁殖材料例如种子、果实、块茎或核仁或者植物插条不受有害生物特别是昆虫和螨虫的侵害。可在施用前用组合物处理该繁殖材料，例如在播种前拌种。也可通过在液体组合物中浸泡核仁或用固体组合物包被核仁，将活性成分施加到种仁上(包被)。当在播种过程中将繁殖材料施加到例如种子播沟内时，也可将该组合物施加到应用地点。这些对植物繁殖材料的处理方法和如此处理的植物繁殖材料都是本发明进一步的主题。
另一方面，本发明的处理还可产生如下的超加和效应：改善植物生长、提高对高温或低温的耐受性、提高对干旱或者对水或土壤含盐量的耐受性、提高开花品质、使采收更简便、加快成熟、提高采收产率、改善采收产品的质量和/或提高其营养价值、改善采收产品的贮存稳定性和/或其加工性能。
本发明的杀虫组合物通常以以下剂量施用是常见的和有利的：
-对于叶部处理：0.1-10000g/ha，优选10-1000g/ha，更优选20-300g/ha；对于浸渍或滴注施用而言，所述剂量甚至还可以降低，特别是当施用惰性基质如石棉或珍珠岩石时；
-对于种子处理：2-200g/100kg种子，优选3-150g/100kg种子；
-对于土壤处理：0.1-10000g/ha，优选1-5000g/ha。
上述剂量仅是一般性的示例性剂量，实际施用时本领域的技术人员会根据实际情况和需要，尤其是根据待处理的植物或作物的性质以及虫害情况来调整施用率。
本发明的杀虫组合物包括分开、依次或同时施用第一活性成分乙螨唑和第二活性成分。
应当指出，本发明的任何实施方案或实施方案的任何技术特征都可以独立地与本发明的任何其它实施方案彼此组合。也就是说，本发明的任何实施方案的一个或多个技术特征都可与任何其它技术特征重新组合。由此技术特征重新组合而形成的技术特征公开在本文中，如其特别记载在本文中一样。
本发明通过两者复配的益处有以下五点：
A、所述杀虫活性超过所述两种活性化合物各自施用时的活性之和；这使得优化所用活性化合物的量成为可能；
B、两者混用，解决了持效期与速效性的问题，从而减少用药次数，降低了人工成本；
C、延缓了抗性的产生：两者作用机理和作用方式完全不同，组合之后具有触杀、胃毒、杀卵及降低产卵率和孵化率的作用，从而使害虫更易被杀灭，从而延缓了抗性的产生；
D、拓展了第一活性成分乙螨唑的防治谱，第二活性成分哒嗪硫磷对果树螨类同期发生的蚜虫均有较好的防治效果，与第一活性成分组合后，有效防治红蜘蛛、蚜虫的同时危害；
E、解决了哒嗪硫磷持效期短，易产生抗药性的问题。
具体实施方式
以下将结合实施例对本发明作进一步的阐述：
制剂实施例
实施例1乳油
第一活性成分乙螨唑 2％
第二活性成分哒嗪硫磷 3％
N-甲基吡咯烷酮 20％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10
SOLVESSOTM200 补足至100％
将上述组分混合搅拌至均一透明的液体，即得到本发明的乳油制剂。
实施例2可湿性粉剂
第一活性成分乙螨唑 10％
第二活性成分哒嗪硫磷 10％
十二烷基硫酸钠 2％
木质素磺酸钠 10％
白炭黑 10％
高岭土 补足至100％
将活性成分、各种助剂及填料等按配方的比例成分混合，经超细粉碎机粉碎后，即得到本发明的可湿性粉剂
实施例3水乳剂
第一活性成分乙螨唑 10％
第二活性成分哒嗪硫磷 2％
N-甲基吡咯烷酮 15％
十二烷基苯磺酸钠 5％
苯乙基苯酚聚氧乙烯醚 5％
水 补足至100％
将原药、溶剂、乳化剂加在一起，使溶解成均匀油相；将水溶性组分和水混合制得水相；在高速搅拌下，将油相与水相混合，制得本发明的水乳剂。
实施例4水分散粒剂
第一活性成分乙螨唑 50％
第二活性成分哒嗪硫磷 10％
木质素磺酸钠 5％
十二烷基硫酸钠 2％
尿素 10％
高岭土 补足至100％
将活性成分、分散剂、润湿剂、崩解剂和填料按配方的比例混合均匀，经过气流粉碎成可湿性粉剂，再加入一定量的水混合挤压造粒。经干燥筛分后得到本发明的水分散粒剂。
实施例5微乳剂
第一活性成分乙螨唑 10％
第二活性成分哒嗪硫磷 50％
N-甲基吡咯烷酮 20％
乙氧基化蓖麻油 5％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 5％
水 补足至100％
将上述组分混合搅拌至均一透明的液体，即得到本发明的微乳剂。
实施例6可湿性粉剂
第一活性成分乙螨唑 50％
第二活性成分哒嗪硫磷 1％
十二烷基硫酸钠 10％
木质素磺酸钠 15％
白炭黑 10％
高岭土 补足至100％
将活性成分、各种助剂及填料等按配方的比例成分混合，经超细粉碎机粉碎后，即得到本发明的可湿性粉剂。
实施例7悬乳剂
第一活性成分乙螨唑 2％
第二活性成分哒嗪硫磷 50％
SOLVESSOTM200 10％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10％
改性木质素磺酸钙 5％
黄原胶 0.5％
膨润土 1％
丙三醇 5％
消泡剂 0.6％
水 补足至100％
将第二活性成分哒嗪硫磷溶解在SOLVESSOTM200中，加入乙氧基化蓖麻油，得到乳油；将第一活性成分，脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠，改性木质素磺酸钙，黄原胶，膨润土，丙三醇，水等上述各组分按比例混合均匀，并经砂磨，制备成悬浮剂。将含第一活性成分乙螨唑的油相加入到含第二活性成分哒嗪硫磷的悬浮剂中，得到悬乳剂。
实施例8水乳剂
油相：
第一活性成分乙螨唑 1％
第二活性成分哒嗪硫磷 10％
油酸甲酯 10％
聚苯乙烯 3.7％
水相：
黄原胶 0.07％
磺化的萘磺酸-甲醛缩合产物的钠盐 1％
杀菌剂 0.2％
水 补足至100％
将第一活性成分乙螨唑和第二活性成分哒嗪硫磷溶解在油酸甲酯中，加入聚苯乙烯得到油相；按照配方中的组分混合均匀得到水相；在搅拌下将油相加入水相得到水乳剂。
实施例9可湿性粉剂
第一活性成分乙螨唑 70％
第二活性成分哒嗪硫磷 20％
木质素磺酸钠 7％
月桂基硫酸钠 2％
高岭土 补足至100％
将上述组合按比例混合，并研磨，粉碎，制备成可湿性粉剂。
实施例10包衣颗粒剂
第一活性成分乙螨唑 30％
第二活性成分哒嗪硫磷 50％
聚乙二醇 3％
高度分散的硅酸 1％
碳酸钙 补足至100％
在混合器中，将磨细的活性成分均匀涂布到被聚乙二醇润湿的载体上。以此方式可获得无尘 包衣颗粒剂。
实施例11可湿性粉剂
第一活性成分乙螨唑 5％
第二活性成分哒嗪硫磷 25％
木质素磺酸钠 10％
十二烷基磺酸钠 3％
白炭黑 5％
高岭土 补足至100％
将上述组分按比例混合，并研磨、粉碎，制备成可湿性粉剂。
实施例12挤出颗粒剂
第一活性成分乙螨唑 1％
第二活性成分哒嗪硫磷 50％
木质素磺酸钠 4％
羧甲基纤维素 2％
白炭黑 5％
高岭土 补足至100％
将活性组分与助剂混合并研磨，混合物用水湿润。将该混合物挤出，然后在空气流中干燥。
实施例13悬乳剂
第一活性成分乙螨唑 20％
第二活性成分哒嗪硫磷 2％
SOLVESSOTM200 10％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10％
改性木质素磺酸钙 5％
黄原胶 0.5％
膨润土 1％
丙三醇 5％
消泡剂 0.6％
水 补足至100％
将第二活性成分哒嗪硫磷溶解在SOLVESSOTM200中，加入乙氧基化蓖麻油，得到乳油；将第一活性成分乙螨唑，脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠，改性木质素磺酸钙，黄原胶，膨润土，丙三醇，水等上述各组分按比例混合均匀，并经砂磨，制备成悬浮剂。将含第二活性成分哒嗪硫磷的油相加入到含第一活性成分乙螨唑的悬浮剂中，得到悬乳剂。
实施例14悬乳剂
第一活性成分乙螨唑 25％
第二活性成分哒嗪硫磷 25％
SOLVESSOTM200 10％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10％
改性木质素磺酸钙 5％
黄原胶 0.5％
膨润土 1％
丙三醇 5％
消泡剂 0.6％
水 补足至100％
将第二活性成分哒嗪硫磷溶解在SOLVESSOTM200中，加入乙氧基化蓖麻油，得到含第二活性成分哒嗪硫磷乳油；将第一活性成分乙螨唑，脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠，改 性木质素磺酸钙，黄原胶，膨润土，丙三醇，水等上述各组分按比例混合均匀，并经砂磨，制备成悬浮剂。将含第二活性成分哒嗪硫磷的油相加入到含第一活性成分乙螨唑的悬浮剂中，得到悬乳剂。
实施例15悬乳剂
第一活性成分乙螨唑 50％
第二活性成分哒嗪硫磷 2％
SOLVESSOTM200 10％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10％
改性木质素磺酸钙 5％
黄原胶 0.5％
膨润土 1％
丙三醇 5％
消泡剂 0.6％
水 补足至100％
将第二活性成分哒嗪硫磷溶解在SOLVESSOTM200中，加入乙氧基化蓖麻油，得到含第二活性成分乳油；将第一活性成分乙螨唑，脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠，改性木质素磺酸钙，黄原胶，膨润土，丙三醇，水等上述各组分按比例混合均匀，并经砂磨，制备成悬浮剂。
将含第二活性成分哒嗪硫磷的油相加入到含第一活性成分乙螨唑的悬浮剂中，得到悬浮乳剂。
实施例16乳油
第一活性成分乙螨唑 5％
第二活性成分哒嗪硫磷 15％
N-甲基吡咯烷酮 20％
乙氧基化蓖麻油 4％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10
SOLVESSOTM200 补足至100％
将上述组分混合搅拌至均一透明的液体，即得到本发明的乳油。
实施例17微囊悬浮-悬浮剂
ATLOXTM4913 4％
柠檬酸 0.05％
催化剂 0.1％
水 13％
第二活性成分哒嗪硫磷 5％
PAP1 1.35％
SOLVESSOTM200 10％
ATLOXTM4913 16％
分散剂LFH 0.3％
消泡剂 0.16％
尿素 8.4％
第一活性成分 25％
水 补足至100％
将多亚甲基多苯基多异氰酸酯(PAPI)，第二活性成分哒嗪硫磷和SOLVESSOTM200形成的油相加入含ATLOXTM4913的水溶液中，形成乳状液。然后加热并保温在50℃下加入催化剂反应2小时。冷却后得到含第二活性成分哒嗪硫磷的微囊剂。
ATLOXTM 4913，分散剂LFH，消泡剂，尿素，第一活性成分乙螨唑和水按比例混合均匀，并经砂磨，制备成悬浮剂。
将得到的含第二活性成分哒嗪硫磷的微囊剂加入第一活性成分乙螨唑的水悬浮剂中，搅拌均匀得到本发明的微囊悬浮-悬浮剂。
实施例18悬浮种衣剂
第一活性成分乙螨唑 5％
第二活性成分哒嗪硫磷 50％
SOLVESSOTM200 20％
乙氧基化蓖麻油 5％
脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠 10％
改性木质素磺酸钠 5％
黄原胶 0.5％
丙三醇 5％
聚乙烯吡咯烷酮(PVP-K30) 1％
消泡剂 0.6％
水 补足至100％
将第二活性成分哒嗪硫磷溶解在SOLVESSOTM200中，加入乙氧基化蓖麻油，得到含第二活性成分哒嗪硫磷的乳油；将第一活性成分乙螨唑，脂肪醇聚氧乙烯醚磺基琥珀酸单酯二钠，改性木质素磺酸钙，黄原胶，丙三醇，聚乙烯吡咯烷酮，水等上述各组分按比例混合均匀，并经砂磨，制备成悬浮剂。
将含第二活性成分哒嗪硫磷的油相加入到含第一活性成分乙螨唑的悬浮种衣剂中，得到本发明的悬浮种衣剂。
实施例19烟雾剂
第一活性成分乙螨唑 5％
第二活性成分哒嗪硫磷 5％
丙二醇 5％
磷酸酯类 3.5％
乙氧基化的蓖麻油 20％
SOLVESSOTM100 补足至100％
首先将防冻剂丙二醇，稀释剂SOLVESSOTM 100混合，搅拌下加入第一活性成分乙螨唑和第二活性成分哒嗪硫磷；将表面活性剂加入其中，在搅拌下通过一个粉碎设备胶体磨进行粉碎，将通过胶体磨后的悬浮液，再经过一个超微粉碎机。循环往复至固体粒子的粒径≤2um为止。
实施例20可湿性粉剂
第一活性成分乙螨唑 50％
第二活性成分哒嗪硫磷 5％
十二烷基硫酸钠 1％
木质素磺酸钠 1％
白炭黑 1％
高岭土 补足至100％
将活性成分、各种助剂及填料等按配方的比例成分混合，经超细粉碎机粉碎后，即得到本发明的可湿性粉剂。
实施例21活性成分结合物
第一活性成分乙螨唑 10％
第二活性成分哒嗪硫磷 90％
将第一活性成分乙螨唑和第二活性成分哒嗪硫磷按配比混合均匀。
以上实施例中的配比为重量百分配比。
实施方式
将不同的有效成分组合制成作物保护产品，是目前开发和研制新作物保护产品以及防治农业上抗性害虫的一种有效和快捷的方式。不同品种的农药混合后，通常表现出三种作用类型：相加作用、增效作用和拈抗作用。但具体为何种作用，无法预测，只有通过大量实验才能知道。复配增效很好的配方，由于明显提高了实际防治效果，降低了农药的使用量，从而大大地延缓了害虫抗药性的产生速度，是综合防治病害的重要手段。
发明人通过大量的筛选试验，对乙螨唑和哒嗪硫磷的不同配比进行了大量试验以及效果性分析，发现在一定的配比范围内，所得到的杀虫组合物具有增益效果，而不仅仅是两种药剂的简单相加，具体用以下实施方式进行说明。
在本发明实施方式中采用室内毒力测定和杀虫试验相结合的方式，首先通过室内毒力测定，明确两种药剂按一定比例复配后的共毒系数(CTC)，CTC＜80为抗拈作用，80≤CTC≤120为相加作用，CTC＞120为增效作用，在此基础上再进行杀虫试验。
计算公式如下：
死亡率(％)＝(药前活虫数-药后活虫数)/药前活虫数*100
校正死亡率(％)＝(处理组死亡率-对照组死亡率)/(100-对照组死亡率)*100
将供试昆虫校正死亡率换算成机率值(y)，处理浓度(μg/ml)转换成对数值(x)，以最小二乘法计算抑制中浓度LC50,再依孙云沛法计算共毒系数(CTC)。计算公式如下(以螺螨双酯为标准药剂，其毒力指数为100)：
实测毒力指数(ATI)＝(标准药剂LC50/供试药剂LC50)×100
理论毒力指数(TTI)＝A药剂ATI×混剂中A的百分含量+B药剂ATI×混剂中B的百分含量共毒系数(CTC)＝(混剂ATI/混剂TTI)×100
试验1：对二斑叶螨的室内毒力测定
试验参照杀虫剂农药室内生物测定试验准则(农业行业标准NY/T1154.7-2006)和创制农药生物活性评价SOP(杀虫剂卷)，采用浸渍法。将菜豆叶子叶片带柄剪下，插于加水的安剖瓶中。接一定数量的成螨。待成螨产卵24h后，去除成螨，将带有足够多卵的叶片浸于药液中10s，迅速用吸水纸吸去多余药液，将叶片重新置于安剖瓶中，自然晾干。置于观察室内培养。试验重复4次，并设空白对照，待对照全部孵化后进行调查。调查时以不能孵化和不能正常爬行的幼螨视为死虫。
表1：
Figure PCTCN2015073287-appb-000003
从表1可知，防治二斑叶螨，乙螨唑与哒嗪硫磷的配比在1:100-100:1的范围里时，共毒系数均大于120，说明两者在这个范围内的混配均表现为增益效果，尤其是当两者的比例在1:5时，增益效果尤为突出。
试验2：对柑橘全爪螨的室内毒力测定结果
采用先浸叶后接虫的方法，将未接触任何药剂的大小一致的叶片在配制好的药液中浸泡5s 后取出、自然晾干，放入养虫盒中，然后接上供试幼虫，在25℃条件下饲养，每处理3次重复，每重复所用试虫数为20头，同时设空白对照，于72h检查死虫数，计算死亡率和校正死亡率，求得毒力回归方程并计算LC50值。若对照死亡率大于10％，则视为无效试验。
表2：
Figure PCTCN2015073287-appb-000004
从表2可知，防治柑橘全爪螨，乙螨唑与哒嗪硫磷的配比在1:100-100:1的范围里时，共毒系数均大于120，说明两者在这个范围内的混配均表现为增益效果，尤其是当两者的比例在1:10时，增益效果尤为突出。
试验3：
当活性化合物组合物的作用超过当各活性化合物单独施用时的作用的总和时，存在协同的杀虫和杀螨作用。两种活性化合物的特定组合的预期作用可使用所谓的"Colby公式"(参见S.R.Colby,"Calculating Synergistic and Antagonistic Responses of Herbicide Combinations“,Weeds 1967,15,20-22)如下计算:如果
X是当使用用量为m g/ha或浓度为m ppm的活性化合物A时的杀死率，表示为占未处理对照的百分率，
Y是当使用用量为n g/ha或浓度为nppm的活性化合物B时的杀死率，表示为占未处理对照的百分率，
E是当使用用量为m和n g/ha或浓度为m和n ppm的活性化合物A和B时的杀死率，表示为占未处理对照的百分率，
那么
Figure PCTCN2015073287-appb-000005
如果实际的杀虫致死率超过计算值，则组合物的致死作用是超加和的，即存在协同作用。在这种情况下，实际观察到的杀死率必须超过使用上述公式计算的预期杀死率值(E)的值。
防治柑橘全爪螨的药效试验
试验如下进行：试验地点为浙江嘉兴，时间为5月初。采用盆栽柑橘试验，苗龄为3年。喷药前每株接种全爪螨雌成螨200头。接种后2天喷药处理。以喷湿叶片正反面为准，每个处理3株柑橘苗。于药后3天、10天、20天和30天采25张叶片于实验室内用双目镜调查叶片上的成螨数，计算虫口减退率和防治效果，公式如下：
具体试验方法及数据如下：
螨口减退率(％)＝(处理区药前活虫数－处理区药后活虫数)/处理区药前活虫数*100
防治效果(％)＝(处理区螨口减退率±对照区螨口减退率)/(100±对照区螨口减退率)*100
表3：
Figure PCTCN2015073287-appb-000006
从表3的试验结果看，乙螨唑和哒嗪硫磷的复配后观察到的防效明显高于计算防效，显示出明显的增效作用。乙螨唑和哒嗪硫磷复配结合了击倒活性和延长防治时间，达到了快速作用和长效作用的效果。
试验二：防治柑橘棉蚜的药效试验
试验如下进行：试验地点为浙江嘉兴，时间为3月初。采用盆栽柑橘试验，苗龄为3年。喷药前每株接种棉蚜成虫200头。接种后2天喷药处理。以喷湿叶片正反面为准，每个处理3株柑橘苗。于药后6天，采25张叶片于实验室内用双目镜调查叶片上的成虫数，计算虫口减退率和防治效果，公式如下：
具体试验方法及数据如下：
虫口减退率(％)＝(处理区药前活虫数－处理区药后活虫数)/处理区药前活虫数*100
防治效果(％)＝(处理区虫口减退率±对照区虫口减退率)/(100±对照区虫口减退率) *100
表4：
Figure PCTCN2015073287-appb-000007
从表4的试验结果看，乙螨唑和哒嗪硫磷的复配后观察到的防效明显高于计算防效，显示出明显的增效作用。

Claims (17)

  1. 一种杀虫组合物，其特征在于：包括第一活性成分乙螨唑
    Figure PCTCN2015073287-appb-100001
    和第二活性成分哒嗪硫磷，
    Figure PCTCN2015073287-appb-100002
    所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷的重量配比为1:100到100:1。
  2. 根据权利要求1所述的杀虫组合物，其特征在于：第一活性成分乙螨唑和第二活性成分哒嗪硫磷的重量配比为1:50到50:1。
  3. 根据权利要求1所述的杀虫组合物，其特征在于：所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷的重量配比为1:25到25:1。
  4. 根据权利要求1所述的杀虫组合物，其特征在于：所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷的重量配比为1:10到10:1。
  5. 根据权利要求1所述的杀虫组合物，其特征在于：所述第一活性成分乙螨唑和第二活性成分哒嗪硫磷总共占所述组合物以重量计的5％-90％。
  6. 根据权利要求1所述的杀虫组合物，其特征在于：所述第一活性成分乙螨唑和第二活性成分总共占所述组合物以重量计的10％-80％。
  7. 根据权利要求1所述的杀虫组合物，其特征在于：所述第一活性成分乙螨唑和第二活性成分总共占所述组合物以重量计的20％-60％。
  8. 根据权利要求1所述的杀虫组合物，其特征在于：还包含表面活性剂和/或增充剂。
  9. 根据权利要求1所述的杀虫组合物，其特征在于：所述剂型为乳油、悬浮剂、种衣剂、水分散粒剂、可湿性粉剂、悬乳剂、挤出颗粒剂、包衣颗粒剂、烟雾剂、水乳剂、微囊悬浮剂、超低容量液剂、微囊悬浮-悬浮剂。
  10. 根据权利要求1所述的杀虫组合物用于预防或控制有害生物的用途。
  11. 一种预防或控制有害生物的方法，其特征在于：将权利要求1的杀虫组合物用于目标有用植物、目标有害生物或其环境、目标有用植物的繁殖材料。
  12. 根据权利要求11所述的一种预防或控制有害生物的方法，其特征在于：所述植物繁殖材料是籽苗、根茎、圃苗、插条或种子。
  13. 根据权利要求11所述的一种预防或控制有害生物的方法，其特征在于：所述有害生物选自昆虫、螨虫。
  14. 根据权利要求11所述的一种预防或控制有害生物的方法，其特征在于：所述有害生物选自红蜘蛛、蚜虫。
  15. 根据权利要求11所述的一种预防或控制有害生物的方法，其特征在于：包括分开、依次或同时施用第一活性成分乙螨唑、第二活性成分哒嗪硫磷。
  16. 根据权利要求11所述的一种预防或控制有害生物的方法，其特征在于：其中第一活性成分乙螨唑和第二活性成分各自是经配制组合物的形式。
  17. 一种保护作物以防有害生物侵袭的方法，其特征在于：包括使目标有用植物、目标有害生物或其环境、目标有用植物的繁殖材料与含第一活性成分乙螨唑和第二活性成分哒嗪硫磷的杀虫组合物接触。
PCT/CN2015/073287 2014-03-11 2015-02-26 杀虫组合物 WO2015135419A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410086887.0 2014-03-11
CN201410086887.0A CN104904743B (zh) 2014-03-11 2014-03-11 杀虫组合物

Publications (1)

Publication Number Publication Date
WO2015135419A1 true WO2015135419A1 (zh) 2015-09-17

Family

ID=54070913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/073287 WO2015135419A1 (zh) 2014-03-11 2015-02-26 杀虫组合物

Country Status (2)

Country Link
CN (1) CN104904743B (zh)
WO (1) WO2015135419A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053407A1 (en) * 2003-12-01 2005-06-16 Syngenta Participations Ag Pesticidally active combinations
CN101779661A (zh) * 2009-12-18 2010-07-21 陕西美邦农资贸易有限公司 甲氨基阿维菌素苯甲酸盐与哒嗪硫磷的复配杀虫剂
CN103461376A (zh) * 2013-09-05 2013-12-25 江苏龙灯化学有限公司 一种含氟虫双酰胺和哒嗪硫磷的农药杀虫组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103651544A (zh) * 2012-09-19 2014-03-26 青岛星牌作物科学有限公司 一种丙溴磷和乙螨唑的杀螨组合物及配方实例
CN103271078B (zh) * 2013-04-10 2017-12-01 重庆硕奥科技有限公司 乙螨唑和丙溴磷的农药组合物
CN103271081B (zh) * 2013-04-10 2017-09-12 湖南农大海特农化有限公司 乙螨唑和三唑磷的农药组合物
CN104106593B (zh) * 2014-06-12 2016-05-18 广东中迅农科股份有限公司 一种含有硝虫硫磷和乙螨唑的杀虫杀螨组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053407A1 (en) * 2003-12-01 2005-06-16 Syngenta Participations Ag Pesticidally active combinations
CN101779661A (zh) * 2009-12-18 2010-07-21 陕西美邦农资贸易有限公司 甲氨基阿维菌素苯甲酸盐与哒嗪硫磷的复配杀虫剂
CN103461376A (zh) * 2013-09-05 2013-12-25 江苏龙灯化学有限公司 一种含氟虫双酰胺和哒嗪硫磷的农药杀虫组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI, HAIPING: "Developing Progresses and Characteristic of Novel Insecticides", JIANGSU CHEMICAL INDUSTRY, vol. 32, no. 01, 29 February 2004 (2004-02-29), pages 6 - 11, XP055223985 *

Also Published As

Publication number Publication date
CN104904743B (zh) 2018-02-13
CN104904743A (zh) 2015-09-16

Similar Documents

Publication Publication Date Title
WO2015135424A1 (zh) 一种杀虫组合物及控制有害生物的方法
WO2015135423A1 (zh) 一种杀虫组合物及其控制有害生物的方法
CN105794813A (zh) 一种杀虫组合物及其控制农业害虫的方法
CN105794788B (zh) 一种杀虫组合物及其控制农业害虫的方法
WO2015135420A1 (zh) 一种杀虫组合物及控制有害生物的方法
CN103478150B (zh) 一种含螺虫乙酯和哒嗪硫磷的农药杀虫组合物
CN107318863B (zh) 一种杀虫组合物
CN114097810B (zh) 一种预防或控制小菜蛾的杀虫组合物
CN107318866A (zh) 一种杀虫组合物
CN105794798B (zh) 一种杀虫组合物
CN105707111B (zh) 一种杀虫组合物及其控制农业害虫的方法
CN105794811B (zh) 一种杀虫组合物及其控制农业害虫的方法
CN103749521A (zh) 一种杀虫组合物
CN105794814B (zh) 一种杀虫组合物及其控制农业害虫的方法
WO2015135419A1 (zh) 杀虫组合物
CN107318879B (zh) 一种杀虫组合物
CN114097798B (zh) 一种杀虫组合物及预防或控制动物害虫的方法
CN107318857A (zh) 一种杀虫组合物
CN107318877A (zh) 一种杀虫组合物
CN114097806B (zh) 一种含有硫代苯甲酰胺类杀虫剂的杀虫组合物
CN107751205A (zh) 一种杀虫组合物及其控制农业有害生物的方法
CN107593728A (zh) 一种杀虫组合物
CN107318862A (zh) 一种杀虫组合物
CN105707078B (zh) 一种杀虫组合物及其控制农业害虫的方法
CN105707115B (zh) 一种杀虫组合物及其控制农业害虫的方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15761506

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15761506

Country of ref document: EP

Kind code of ref document: A1