WO2015126129A3 - C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도 - Google Patents

C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도 Download PDF

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Publication number
WO2015126129A3
WO2015126129A3 PCT/KR2015/001577 KR2015001577W WO2015126129A3 WO 2015126129 A3 WO2015126129 A3 WO 2015126129A3 KR 2015001577 W KR2015001577 W KR 2015001577W WO 2015126129 A3 WO2015126129 A3 WO 2015126129A3
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WIPO (PCT)
Prior art keywords
hepatitis
resveratrol
multimer
virus genome
genome replication
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PCT/KR2015/001577
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English (en)
French (fr)
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WO2015126129A2 (ko
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이충호
윤기동
허태회
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동국대학교 산학협력단
가톨릭대학교 산학협력단
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Publication of WO2015126129A2 publication Critical patent/WO2015126129A2/ko
Publication of WO2015126129A3 publication Critical patent/WO2015126129A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤(resveratrol) 다량체 및 이의 용도에 관한 것으로서, 보다 구체적으로는 C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤(resveratrol) 다량체 및 이를 포함하는 C형 간염의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 레스베라트롤(resveratrol) 다량체는 간세포에 대한 독성이 매우 낮으면서도, C형 간염 바이러스의 게놈 복제를 선택적으로 저해하는 우수한 효과를 가지고 있어, C형 간염을 예방, 개선 또는 치료하기 위한 약학적 조성물 또는 기능성 식품 조성물의 활성성분으로 유용하게 사용될 수 있을 것으로 기대된다.
PCT/KR2015/001577 2014-02-18 2015-02-16 C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도 WO2015126129A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140018552A KR101584885B1 (ko) 2014-02-18 2014-02-18 C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도
KR10-2014-0018552 2014-02-18

Publications (2)

Publication Number Publication Date
WO2015126129A2 WO2015126129A2 (ko) 2015-08-27
WO2015126129A3 true WO2015126129A3 (ko) 2017-05-18

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PCT/KR2015/001577 WO2015126129A2 (ko) 2014-02-18 2015-02-16 C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도

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KR (1) KR101584885B1 (ko)
WO (1) WO2015126129A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109897021B (zh) * 2017-12-07 2021-09-14 中国医学科学院药物研究所 葡萄藤戊素衍生物、其制法以及药物组合物与用途
CN110433153A (zh) * 2018-05-03 2019-11-12 中国医学科学院药物研究所 一类Amurensin H衍生物在治疗和预防肝脏相关疾病中的应用
CN110433152A (zh) * 2018-05-03 2019-11-12 中国医学科学院药物研究所 一类葡萄藤戊素衍生物在制备治疗肝脏相关疾病药物中的应用
CN112236136B (zh) * 2018-10-04 2023-12-01 Ms健康科学实验室株式会社 改善肠道菌群的组合物
WO2024018018A1 (fr) 2022-07-21 2024-01-25 Etablissement Francais Du Sang Utilisation d'un composé vitisine pour la production de cellules hématopoïétiques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100584837C (zh) * 2003-10-21 2010-01-27 复旦大学 羟基茋类化合物及其制备方法和应用

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* Cited by examiner, † Cited by third party
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KR100447608B1 (ko) * 2001-06-12 2004-09-07 김종성 작약씨로부터 항암 및 항돌연변이성 트란스-레즈베라트롤및 그 유도체의 추출방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100584837C (zh) * 2003-10-21 2010-01-27 复旦大学 羟基茋类化合物及其制备方法和应用

Non-Patent Citations (3)

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CHEN, XIAOQING ET AL.: "Inhibition of Herpes Simplex Virus Infection by Oligomeric Stilbenoids through ROTS Generation", ANTIVIRAL RESEARCH, vol. 95, no. 1, July 2012 (2012-07-01), pages 30 - 36, XP028491142 *
HUANG, YU-LING ET AL.: "+)-Vitisin A Inhibits Influenza A Virus-induced RANTES Production in A549 Alveolar Epithelial Cells through Interference with Akt and STAT1 Phosphorylation", PLANT A MEDICA, vol. 74, no. 2, February 2008 (2008-02-01), pages 156 - 162, XP018024472 *
PFLIEGER, AUDE ET AL.: "Natural Stilbenoids Isolated from Grapevine Exhibiting Inhibitory Effects against HIV-1 Integrase and Eukaryote MOS1 Transposase in Vitro Activities", PLOS ONE, vol. 8, no. 11, 28 November 2013 (2013-11-28), pages 1 - 13, XP002729520 *

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WO2015126129A2 (ko) 2015-08-27
KR20150097256A (ko) 2015-08-26
KR101584885B1 (ko) 2016-01-15

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