WO2015115923A3 - A profile of microrna in the blood as a test for the detection of lung cancer - Google Patents

A profile of microrna in the blood as a test for the detection of lung cancer Download PDF

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Publication number
WO2015115923A3
WO2015115923A3 PCT/PL2015/000010 PL2015000010W WO2015115923A3 WO 2015115923 A3 WO2015115923 A3 WO 2015115923A3 PL 2015000010 W PL2015000010 W PL 2015000010W WO 2015115923 A3 WO2015115923 A3 WO 2015115923A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
lung cancer
test
microrna
blood
Prior art date
Application number
PCT/PL2015/000010
Other languages
French (fr)
Other versions
WO2015115923A2 (en
Inventor
Witold RZYMAN
Rafał DZIADZIUSZKO
Jacek Jassem
Joanna POLAŃSKA
Piotr WIDŁAK
Original Assignee
Gdanski Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gdanski Uniwersytet Medyczny filed Critical Gdanski Uniwersytet Medyczny
Publication of WO2015115923A2 publication Critical patent/WO2015115923A2/en
Publication of WO2015115923A3 publication Critical patent/WO2015115923A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The object of the invention is a predictive method for the detection and/or exclusion of lung cancer, which involves the measurement of expression levels of miRNA in the test sample, involving: — Detection, in the biological sample, of at least 3 miRNAs from the list of 24 miRNAs, and determination of the amounts of the indicated miRNAs relative to the control sample. Furthermore, an object of the invention is also the use of this method for the detection of lung cancer in individuals at high risk of lung cancer.
PCT/PL2015/000010 2014-01-29 2015-01-29 A profile of microrna in the blood as a test for the detection of lung cancer WO2015115923A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL406989A PL406989A1 (en) 2014-01-29 2014-01-29 Profile of micro RNA in blood as the test for detecting lung cancer
PLP.406989 2014-01-29

Publications (2)

Publication Number Publication Date
WO2015115923A2 WO2015115923A2 (en) 2015-08-06
WO2015115923A3 true WO2015115923A3 (en) 2015-10-01

Family

ID=52697507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2015/000010 WO2015115923A2 (en) 2014-01-29 2015-01-29 A profile of microrna in the blood as a test for the detection of lung cancer

Country Status (2)

Country Link
PL (1) PL406989A1 (en)
WO (1) WO2015115923A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6991433B2 (en) 2014-06-18 2022-01-12 東レ株式会社 Lung cancer detection kit or device and detection method
WO2017221744A1 (en) * 2016-06-24 2017-12-28 国立大学法人名古屋大学 METHOD FOR PROVIDING DATA FOR LUNG CANCER TEST, LUNG CANCER TEST METHOD, LUNG CANCER TEST DEVICE, PROGRAM AND RECORDING MEDIUM OF LUNG CANCER TEST DEVICE, AND miRNA ASSAY KIT FOR LUNG CANCER TEST
EP3647422B1 (en) 2017-06-29 2024-07-24 Toray Industries, Inc. Kit, device, and method for lung cancer detection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010139810A1 (en) * 2009-06-05 2010-12-09 Febit Holding Gmbh Mirna fingerprint in the diagnosis of lung cancer
WO2012089630A1 (en) * 2010-12-30 2012-07-05 Fondazione Istituto Firc Di Oncologia Molecolare (Ifom) A METHOD TO IDENTIFY ASYMPTOMATIC HIGH-RISK INDIVIDUALS WITH EARLY STAGE LUNG CANCER BY MEANS OF DETECTING miRNAs IN BIOLOGIC FLUIDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010139810A1 (en) * 2009-06-05 2010-12-09 Febit Holding Gmbh Mirna fingerprint in the diagnosis of lung cancer
WO2012089630A1 (en) * 2010-12-30 2012-07-05 Fondazione Istituto Firc Di Oncologia Molecolare (Ifom) A METHOD TO IDENTIFY ASYMPTOMATIC HIGH-RISK INDIVIDUALS WITH EARLY STAGE LUNG CANCER BY MEANS OF DETECTING miRNAs IN BIOLOGIC FLUIDS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LORENZO F. SEMPERE ET AL: "Tumor-Suppressive microRNAs in Lung Cancer: Diagnostic and Therapeutic Opportunities", THE SCIENTIFIC WORLD JOURNAL, vol. 9, 1 January 2009 (2009-01-01), pages 626 - 628, XP055201895, DOI: 10.1100/tsw.2009.88 *
PETRA LEIDINGER ET AL: "MicroRNAs - Important Molecules in Lung Cancer Research", FRONTIERS IN GENETICS, vol. 2, 1 January 2012 (2012-01-01), XP055201827, DOI: 10.3389/fgene.2011.00104 *

Also Published As

Publication number Publication date
WO2015115923A2 (en) 2015-08-06
PL406989A1 (en) 2015-08-03

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