WO2015108495A1 - Dispositif de transfert de fluide ayant un composant de perçage - Google Patents

Dispositif de transfert de fluide ayant un composant de perçage Download PDF

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Publication number
WO2015108495A1
WO2015108495A1 PCT/TR2015/000026 TR2015000026W WO2015108495A1 WO 2015108495 A1 WO2015108495 A1 WO 2015108495A1 TR 2015000026 W TR2015000026 W TR 2015000026W WO 2015108495 A1 WO2015108495 A1 WO 2015108495A1
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WO
WIPO (PCT)
Prior art keywords
fluid transfer
transfer device
spring member
locking members
adapter
Prior art date
Application number
PCT/TR2015/000026
Other languages
English (en)
Inventor
Oguz Bozkurt Cimir
Original Assignee
Tim Plastik Ve Kalip Teknolojileri Endustri Ve Tic A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tim Plastik Ve Kalip Teknolojileri Endustri Ve Tic A.S. filed Critical Tim Plastik Ve Kalip Teknolojileri Endustri Ve Tic A.S.
Publication of WO2015108495A1 publication Critical patent/WO2015108495A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end

Definitions

  • the present invention relates to a fluid transferring device having improved safety and functional structure which ensures ease of manufacture. More particularly, the invention relates to an adapter device of the type having a piercing member for transferring of medicaments from one vessel to another with an improved functionality and safety while providing a specially designed spring member that simplifies manufacturing of the device.
  • Liquid medicaments, prodrugs, biologic samples or diagnosis agents are generally stored in rigid or semi-rigid vessels such as bottles, vials or otherwise in plastic bags, and these sometimes need to be transferred very carefully in order to avoid spillage of the liquid material as well as vapour thereof which can be detrimental for the health of medical stuff as well as the patient. Therefore, it has long been a challenge in the medical device sector to provide functionally improved and safe medical adapters and medication transfer devices with the objective of maximal sealing from the surroundings.
  • a fluid transfer device of the kind that has a piercing member enclosed in a protection chamber is disclosed in WO 2008/136720 Al wherein first and second connection parts are rotatably engaged to each other in order to provide safer handling and administration of drugs and other medical substances.
  • This arrangement has several drawbacks in terms of safety, production and use.
  • the device for instance comprises several components slidable along an axis and rotatable in radial direction which apparently increase complexity and production costs.
  • a more simplified device for transferring of medicaments is disclosed in WO 03/086530 Al wherein the device exhibits a first end and a second end for attachment to a bottle and infusion port, respectively.
  • This device is not suitable to be used with a syringe and it further suffers of several drawbacks because the device is still complicated with its telescopically arranged structure and is also lacking of a safety measure against unintentional exposure of the needle outside as well as leakage or spillage of the medical agent after removal of the device from the liquid transfer assembly.
  • EP 0 888 794 A2 discloses a fluid transfer device having an access cannula and blunt cannula wherein a spring means is provided for helping to position said access cannula within the passageway of the blunt cannula.
  • the spring means can be a coil spring or can be made of an elastic material which can seal, to a certain extent, surrounding of the cannula.
  • the fluid transfer device is nevertheless insufficient for satisfactory sealing at proximal end where access cannula is operated.
  • US 2013/0006200 Al discloses a female piercing member protection device for connection with a male connection part in order to avoidance of undesired exposure to and leakage of hazardous medicaments, although the female part is always in need of being used together with the corresponding male part for safety concerns. Because the tip of the piercing member, i.e. the needle, is kept in between barriers of female and male parts in inactivated position, the female part per se is not suitable to be used alone, and therefore is not flexible enough to be used with different varieties of vessels, vials, plastic bags, adapters etc. Moreover, the device is still complicated enough in terms of use and production.
  • the activated position for instance can only be reached when the outer casing has been turned to a second position, and the connection member is moved along the longitudinal axis (A).
  • a well known type of snap-fit like connection for easy mantling and dismantling of a device is disclosed in WO 2009/090627 which involves two bores in different diameters wherein a plurality of resilient leaves are provided in an expanded position within the larger bore, which however are squeezed upon moving into the narrower bore. Connection principles of this fashion are also known in earlier patents such as US 4,895,570 and EP 0 367 549 which all the way suffer at least one of the problems mentioned above.
  • Figure 1 shows a cross-sectional view of the fluid transfer device (1) according an embodiment of the present invention.
  • Figure 2 shows an assembly comprising the fluid transfer device (1) of the present invention, for transferring of a liquid from a vial (300) to an injection device (100) wherein the device (1) is in activated position.
  • Figures 3a, 3b and 3c show different views of the spring member (11) belonging to the device (1) according to an embodiment of the present invention.
  • Figure 4 shows a mode of fluid transfer from a vial (300) to an injection device (100) by using an aeration cannula adapter (200) and the fluid transfer device (1) according to the present invention.
  • Figure 5 shows a proper functioning of the fluid transfer device (1) according to the present invention.
  • Figure 6 demonstrates safety level in case of a malfunctioning of the fluid transfer device (1) according to this invention.
  • Figures 7 and 8 show the use of different aeration cannula adapters (200) in combination with the fluid transfer device (1) of the current invention.
  • Figure 9 shows a further embodiment of the fluid transfer device (1) with clips associated with locking members (5).
  • Figures 10 and 11 show a different use of the device (1) in combination with an adapter (500) having two inlet ports.
  • Figure 12 shows a spike adapter (600) that can be used with the device (1) of the present invention.
  • Figure 13 shows another use involving the device (1) and a spike adapter (700) having two inlet ports for transferring of a medicament from an injection device (100) to a plastic bag (400) and subsequently transferring the same from the plastic bag (400) to another vessel or directly to a patient.
  • a spike adapter (700) having two inlet ports for transferring of a medicament from an injection device (100) to a plastic bag (400) and subsequently transferring the same from the plastic bag (400) to another vessel or directly to a patient.
  • Figure 14 shows a spike adapter as used in Fig. 13 having a port (720) for connection to the device (1) and having another port (710) for connection to the plastic bag (400).
  • the present invention relates to a fluid transfer device (1) comprising an outer casing (6), a proximal end (8), a piercing member (3), a pierceable seal (4) arranged against said piercing member (3) and a distal end (D) with a number of locking members (5).
  • Said piercing member (3) that is partially held in a channel (2) extends from the proximal end (8) longitudinally through the distal end (D) to provide a fluid passageway therebetween in an activated position of the device (1).
  • the device (1) of the present invention further comprises a spring member (11) made of an elastic material extending from the proximal end (8) longitudinally through the distal end (D) in a manner surrounding the piercing member (3) in fluid tight fashion and forming an inner through channel (22) therein.
  • Said spring member (11) comprises an upper portion (12), a sealing portion (13), and a number of locking members (14) in close proximity to the said distal end (D), wherein said upper portion (12), sealing portion (13), and locking members (14) are integrally molded as a one piece unit.
  • Said upper portion (12) is flexible such that being movable between an activated position (dawn) and deactivated position (up).
  • Said locking members (14) comprise a claw like structure that is tightly squeezed around the surface to be connected in an activated position of the device (1).
  • the locking members (14) preferably comprise a ring shaped protrusion (21) surrounding, in horizontal direction, the said locking members (14).
  • the device (1) of the present invention has a hallow inner surface, and is preferably having groove (22) corresponding to the aforesaid protrusion (21).
  • This groove (22) receives the protrusion (21) in a deactivated position of the device (1) as shown in Fig. 1.
  • the protrusion (21) of the locking members (14) dismantles from the corresponding groove (22) causing an inwardly bending of the locking members (14) and providing a squeezing function.
  • the piercing member (3) is arranged in a position pricked within the pierceable seal (4) when the device (1) rests in a deactivated position.
  • the proximal end (8) of the device (1) is also configured to make a female connection with for instance an injection device, more particularly with a standard syringe device.
  • said flexible upper portion (12) is formed as a bellow which is advantageous for obtaining a more stable flexibility.
  • the sealing portion (13) of the spring member (11) comprises a seat for housing the pierceable seal (4) such that the piercing member (3) is isolated from outside within the through channel (23) of the spring member (11).
  • the present invention is disclosed in more detail with reference to different embodiments hereinbelow.
  • the invention is mainly directed to a fluid transfer device (1) in the form of an adapter which can be used for instance as a conduit in between several components known in the art, for instance syringes, vials, bottles, plastic bags, cannulas and various adapters used for transferring of liquids, more preferably of medicaments or any biological liquids from one storage medium to another.
  • the device according to the present invention is particularly suitable for use in transferring of hazardous medicaments or biologic material, exposure to which causes undesirable health risks in medical staff and patients.
  • the fluid transfer device (1) of the present invention comprises a tubular rigid casing (6) which optionally includes a clips (7) (Fig. 9) for dismantling of the locking members (5) after the transferring operation.
  • Said clips (7) may be preferable as it helps easily to move away another device (e.g. vial, cannula, bottle or any adapter) after usage, and it also prevents unintentional detachment of the device (1) from another vial or adapter.
  • the fluid transfer device (1) of the current invention further comprises a proximal end (8) and a distal end (D) that provide fluid tight connection to other devices and vessels.
  • said proximal end (8) is of the type of a female connection part, preferably threaded in order to, for instance fixedly connect to an injection device (100) (e.g. syringe) as shown in Figure 2.
  • an injection device e.g. syringe
  • this proximal end (8) may be adapted to make connection to any vial, syringe or adapter such that a fluid tight connection in transfer of fluid is achieved.
  • a piercing member (3) and a spring member (11) extending longitudinally inside the rigid casing (6).
  • the spring member (11) itself surrounds the piercing member (3) such that it is isolated from casing (6) of the device (1) and is operated within the through channel (23) of the spring member (11).
  • Said spring member (11) mainly comprises an upper portion (12), a sealing portion (13) and a number of locking members (14) preferably in the form of claws.
  • the spring member (11) having the components above is made of an elastic material such as natural rubber, synthetic rubber or thermoplastic elastomer, but more preferably of thermoplastic polyurethane (TPU).
  • the upper portion (12) extending longitudinally inside the casing (6) is preferably formed as a bellow which is found to be the most advantageous configuration for easy and stable movement of the device (1) during activation and deactivation positioning upon another device.
  • said upper portion (12), sealing portion (13) and the locking members (14) of the spring member (11) are integrally molded to have a one piece structure. This is not only advantageous for ease of manufacturing but also provides a perfectly sealed and safe arrangement during operation and post-operation of the device (1). Referring again to Fig. 1, where the device (1) rests in a deactivated position, the spring member (11) remains unloaded. Tip portion (9) of the piercing member (3), is also secured in deactivated position inside the through channel (23) of the spring member (11).
  • the tip portion (9) in this position is arranged to be pricked into the pierceable seal (4) that is placed in a sealing seat within the seal portion (13) of the spring member (11).
  • the details of the spring member (11) can be seen in detail in Figures 3a, 3b and 3c.
  • the spring member (11) of the current invention has a proximal end (19) having an enlarged width or radius compared to the upper portion (12) that enables fixation in between the needle holder (10) and casing (6) of the fluid transfer device (1). This is preferably the only fixation point of said spring member (11) inside the casing (6) which enables a very easy production procedure and avoidance of complicated components.
  • the fluid transfer device (1) may for instance be used in transferring of a liquid medicament from a vial (300) to an injection device (100) or vice versa, as shown in Figures 2.
  • the proximal end (8) of the device (1) can be coupled to the injection device (100) while the distal end (D) is coupled to an adapter (200).
  • proximal end (8) of the fluid transfer device (1) can be adopted for connection to a tip portion of the conventional syringes which can be used as an injection device (100).
  • the fluid transfer device (1) of the current invention when placed on an adapter-vial arrangement, can be easily activated by a simple longitudinal force in which case a top portion or top sealing (204) of the adapter (200) abuts to the sealing portion (13) of the spring member (11) as well as to the pierceable sealing (4) located therein.
  • a top portion or top sealing (204) of the adapter (200) abuts to the sealing portion (13) of the spring member (11) as well as to the pierceable sealing (4) located therein.
  • the spring member (11), particularly upper portion (12) thereof is loaded and compressed which eventually causes the piercing member (3) to move distally along the pierceable seal (4) and to be exposed through inside of the adapter (200) as shown in Fig. 2.
  • both the locking members (14) of the spring member (11) and locking members (5) of the casing (6) are engaged to corresponding protrusions (202, 203) of the adapter (200) to provide a "double locking". Therefore, a perfectly secured arrangement is provided in a fluid tight manner by applying a force only in "one direction”.
  • the flow of the liquid from the vial (300) to the injection device (100) is illustrated in Fig. 4.
  • the white arrows in this figure represent the air flow while the black arrows represent the liquid flow.
  • the cannula of the adapter (200) includes a liquid passageway (205) and air passageway (206) for transfer of the liquid through the device (1) properly.
  • the air supply means (207) can be of any type such as a filter type as in Fig. 7, or a receptacle type as shown in Fig. 8 or a combination of both.
  • the receptacle types can be flexible (e.g. bellow) that contain prefilled clean air to be supplied into the vial (300) for purposes of pressure equalizing.
  • a filter type air supply means (207) is particularly preferred as it provides a more compact structure and practical use.
  • the filter can have apertures of 0.1 to 0.7 ⁇ , more particularly of about 0.2 ⁇ which can substantially clean the air from contaminants.
  • the device (1) can be deactivated and detached after completion of the fluid transfer similarly by applying an inverse longitudinal force only in one direction.
  • a clips (7) arrangement connected to the locking members (5) is used (Fig. 9)
  • the user may easily dismantle said locking members (5) via said clips (7), in which case said device (1) automatically turns into the normal position of Fig. 1, without needing of any other rotational movement, where the piercing member (3) turns into a perfectly secured and sealed position.
  • Figs. 3a, 3b and 3c showing the spring member (11) in different perspectives.
  • distal end (D) of the fluid transfer device (1) according to the present invention is configured as a female connection part, and therefore locking members (14) of the spring member (11) are also arranged as a female connection part that provide an additional locking means (i.e. double locking) of the device (1).
  • the double locking can be realized upon the corresponding protrusions (202, 203) on an adapter or even on a vial.
  • the spring member (11) itself functions as a seal isolating the piercing member (3) from the external casing (6) and outside.
  • the sealing portion (13) of the spring member (1 1) is provided with a special arrangement as shown in detail with Fig. 3c.
  • This arrangement mainly comprises an outer wall (17) and an inner wall (16) which are concentrically formed and having a spacing (15) therebetween.
  • the spacing (15) as mentioned herein is adapted to receive a corresponding protrusion (203) of an adapter or vial.
  • locking of an elastic member such as the locking members (14) of the spring member (11) according to this invention to a corresponding protrusion (203) of an adapter or vial could be problematic because the elastic claws would not be rigid enough to grip the said protrusion (203) which would likely result in a malfunction in terms of sealing and locking.
  • the present invention solves this additional problem by a specially arranged locking members (14) as an integral part of the spring member (11), comprising a ring shaped protrusion (21) that is normally accommodated in a corresponding groove (22) of the casing (6).
  • This arrangement advantageously enables the technical effect that once the device (1) is activated and spring member (11) is loaded, the protrusion (21) of the locking members (14) dismantles from the corresponding groove (22) and moves upwardly causing inwardly bending of the locking members (14) such that squeezing around the periphery of a male connection port (e.g. a collar or protrusion; 203) of another device.
  • a male connection port e.g. a collar or protrusion; 203
  • the longitudinal force causes the spring member (11) to be loaded and moved proximally in the direction of the proximal end (8), where in this instance the locking members (14) of the spring member (11) are squeezed to a certain extent in central direction.
  • a connection of this fashion constitutes a first locking which is also sealing an opening of the said male connection part, whereas the locking members (5) of the casing (6) provides an additional lock function on a corresponding protrusion (202).
  • the latter locking means fixes the overall device (1) to the adapter (200) or where appropriate to a vial (300) such that the loaded spring member (11) does not cause a detachment without intention of the user.
  • the device (1) of the current invention provides an excellent safety without needing extra locking means operated by complicated components and movement in different axis (i.e. transversally or radially).
  • the spring member (11) which acts also as a sealing around the piercing member (3) is also advantages even in malfunction of the pierceable seal (4) of the device (1). This is best illustrated in Figures 5 and 6 which show proper and malfunction states of the system, respectively. As can be seen in Fig. 6, the spring member (1 1) successfully stores the liquid within the through channel (23) without any leakage to the casing (6).
  • the fluid transfer device (1) of the present invention is described in an exemplary system containing a vial (300), adapter (200) and an injection device (100), it can also be used in other systems, for instance for transferring of liquid medicament from a vial (300) to another vessel such as a plastic bag (400).
  • An adapter (500; 700) with two inlet ports can advantageously be used as shown in Figures 10, 1 1, 13 and 14 for transferring of a liquid into two different receptacles.
  • a medicament for instance can be transferred from a vial (300) to any receptacle such as a plastic bag as shown in the configuration of Figures 10 and 11.
  • the adapter (500) is adapted to operate with one injection device (100) and two fluid transfer devices (1) according to the present invention.
  • the adapter (500) having two inlets can for instance be connected to the fluid transfer devices (1) via first and second ports (501, 502) with a luer lock connection style from the proximal ends (8) of the devices (1) wherein one of the devices (1) is connected to a vial (300) and the other is adapted to connect to a plastic bag (not shown) via a spike adapter (600).
  • any kind of adapter that is connected to the distal end (D) of the device (1) such as the one mentioned above is needed to have circumferential protrusions (602, 603) in order to achieve a "double locking" connection as identified in foregoing sections.
  • the first protrusion (602) is designed to engage with locking members (5) of the casing (6) and the other protrusion (603) is designed to engage with locking members (14) of the spring member (11).
  • a medicament in a vial (300) can be transferred into another receptacle (e.g. plastic bag) by drawing it firstly into the injection device (100) and then injecting the same through the adapter (500) to another fluid flow way without detachment of the any of the devices within the assembly.
  • the liquid medicament is transferred from the injection device (100) to a receptacle (400) (e.g. plastic bag) which release the said medicament in a predetermined dosage rate to a patient as shown in Fig. 13.
  • a receptacle e.g. plastic bag
  • the dashed arrows show the direction of the fluid flow within this assembly.
  • a spike adapter (700) with two inlet ports as shown in Fig. 14 is used for this purpose.
  • Said adapter (700) may comprise a cannula (710) that is adapted to engage to a hose of the receptacle (400) while one of the ports (720) is also adapted to engage with the fluid transfer device (1) according to the present invention by way of locking to the protrusions (721, 722) provided circumferentially on the relevant port (720).
  • the other port (730) of the adapter (700) may be adapted to engage with a further port delivering the medicament to the patient.
  • the fluid transfer device (1) according to the present invention can be used with various fluid transfer systems including various components such as injection devices (100), vial adapters (200), adapters with two inlets (500, 700), and spike adapters (600). It is therefore an aspect of the present invention to provide a kit of parts comprising;
  • At least one injection device (100) that is adapted to engage in a fluid tight manner to the proximal end (8) of the fluid transfer device (1)
  • At least one adapter (200, 500, 600, 700) adapted to engage with the fluid transfer device (1).
  • At least one adapter comprises a first circumferential protrusion (202; 602; 721) that is adapted to engage with locking members (5) of the casing (6), and a second circumferential protrusion (203; 603; 722) adapted to be engaged with locking members (14) of the spring member (11) at a distal end (D) of the fluid transfer device (1).
  • the kit of parts preferably contains an adapter (500; 700) with two inlet ports at least one port of which is adapted to be engaged in a double locking manner with the fluid transfer device (1) of the present invention.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un dispositif de transfert de fluide (1) comprenant un boîtier externe (6), une extrémité proximale (8), un composant de perçage (3), un joint d'étanchéité perçable (4) agencé contre ledit composant de perçage (3) et une extrémité distale (D) avec une pluralité d'éléments de verrouillage (5). Le dispositif (1) comprend en outre un composant de ressort (11) constitué d'un matériau élastique s'étendant depuis l'extrémité proximale (8) longitudinalement à travers l'extrémité distale (D) d'une manière entourant le composant de perçage (3) de façon hermétique aux fluides et formant un canal de passage interne (23) dans celui-ci. Ledit composant de ressort (11) comprend une partie supérieure (12), une partie d'étanchéité (13), et une pluralité de composants de verrouillage (14) à proximité étroite de ladite extrémité distale (D), qui sont moulés en une seule pièce.
PCT/TR2015/000026 2014-01-14 2015-01-14 Dispositif de transfert de fluide ayant un composant de perçage WO2015108495A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14151085.9 2014-01-14
EP14151085.9A EP2893916B1 (fr) 2014-01-14 2014-01-14 Dispositif de transfert de fluide comportant un élément de perçage

Publications (1)

Publication Number Publication Date
WO2015108495A1 true WO2015108495A1 (fr) 2015-07-23

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Cited By (2)

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JP2018538095A (ja) * 2015-12-22 2018-12-27 エクアシールド メディカル リミテッド コネクタ部
CN115607445A (zh) * 2022-07-01 2023-01-17 湛江健力源医疗用品有限公司 一种侧导管型全封闭式安全配药装置

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EP4190304A1 (fr) * 2018-05-25 2023-06-07 Becton Dickinson France Procédé de remplissage d'un dispositif d'injection médical avec une composition
AU2020316106A1 (en) * 2019-07-24 2022-02-03 Enable Injections, Inc. Medical fluid injection and transfer devices and method

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WO2003086530A1 (fr) 2002-04-17 2003-10-23 Carmel Pharma Ab Procede et systeme de transfert de fluide dans un systeme a perfusion
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WO2013119823A1 (fr) 2012-02-07 2013-08-15 Yukon Medical, Llc Dispositif de transvasement équipé d'un filtre pour fluide

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US2342215A (en) * 1942-08-03 1944-02-22 Harold N Perelson Dispensing and sealing stopper
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* Cited by examiner, † Cited by third party
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JP2018538095A (ja) * 2015-12-22 2018-12-27 エクアシールド メディカル リミテッド コネクタ部
US11026864B2 (en) 2015-12-22 2021-06-08 Equashield Medical Ltd. Connector section
CN115607445A (zh) * 2022-07-01 2023-01-17 湛江健力源医疗用品有限公司 一种侧导管型全封闭式安全配药装置
CN115607445B (zh) * 2022-07-01 2024-03-01 广东健力源医疗科技有限公司 一种侧导管型全封闭式安全配药装置

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