WO2015097190A3 - Device and method for characterisation of biological samples - Google Patents
Device and method for characterisation of biological samples Download PDFInfo
- Publication number
- WO2015097190A3 WO2015097190A3 PCT/EP2014/079080 EP2014079080W WO2015097190A3 WO 2015097190 A3 WO2015097190 A3 WO 2015097190A3 EP 2014079080 W EP2014079080 W EP 2014079080W WO 2015097190 A3 WO2015097190 A3 WO 2015097190A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reflector
- sample
- skin
- extracted
- incident radiation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/0009—Testing for drug or alcohol abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/008—Interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Dermatology (AREA)
Abstract
An apparatus for measuring the concentration of an analyte in a sample extracted from the skin (10) of a patient comprises a collection chamber (3) adjacent to the skin; a radiation source (7) configured to irradiate the sample in the collection chamber (3); a reflector (4) configured to reflect incident radiation back through the sample; and a sensor (11) configured to measure the radiation emitted from the sample. The reflector (4) may shield the skin (10) from the incident radiation and have a convoluted or perforated shape to permit sufficient diffusion of the extracted analyte to all parts of the surface of the reflector from its edges. The reflector (4) may be a reflective surface of reverse iontophoresis electrodes (9) used to extract the sample from the skin. In a further apparatus the reflector (4) is implanted beneath an outer layer of the skin (10) so that instead of being extracted, the sample can be measured in vivo. An implanted reflector (4) may be formed from an assemblage of reflective particles. A mask (5) may be provided to prevent the incident radiation bypassing the reflector (4).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1322953.9A GB2521627A (en) | 2013-12-23 | 2013-12-23 | Device and method for characterisation of biological samples |
GB1322953.9 | 2013-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015097190A2 WO2015097190A2 (en) | 2015-07-02 |
WO2015097190A3 true WO2015097190A3 (en) | 2016-05-26 |
Family
ID=50114708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2014/079080 WO2015097190A2 (en) | 2013-12-23 | 2014-12-22 | Device and method for characterisation of biological samples |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB2531956A (en) |
WO (1) | WO2015097190A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2774983B2 (en) | 2019-01-22 | 2021-06-10 | Univ Sevilla | PORTABLE DEVICE AND METHOD FOR NON-INVASIVE ESTIMATION OF GLUCOSE LEVEL IN BLOOD |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995022927A1 (en) * | 1994-02-23 | 1995-08-31 | Peyman Gholam A | Diagnostic system and method using an implanted reflective device |
EP1129353A1 (en) * | 1999-09-10 | 2001-09-05 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analytes in vivo |
DE10212140A1 (en) * | 2002-03-19 | 2003-10-09 | Henry Arthur Muglia | Blood sugar sensor and measuring method for determining the blood sugar value |
US20030225322A1 (en) * | 2001-11-22 | 2003-12-04 | Kenichi Uchiyama | Optical waveguide sensor, device, system and method for glucose measurement |
US20040012788A1 (en) * | 2002-06-19 | 2004-01-22 | Omron Corporation | Method for measuring concentration of component contained in bodily fluid and apparatus for measuring concentration of component contained in bodily fluid |
JP2004159994A (en) * | 2002-11-14 | 2004-06-10 | Toshiba Corp | Apparatus and measuring method for reverse iontophoresis |
WO2004085995A2 (en) * | 2003-03-24 | 2004-10-07 | Rosedale Medical Inc. | Analyte concentration detection devices and methods |
US20060198762A1 (en) * | 2005-03-04 | 2006-09-07 | Ikuo Uematsu | Optical glucose sensor chip |
US7236812B1 (en) * | 2003-09-02 | 2007-06-26 | Biotex, Inc. | System, device and method for determining the concentration of an analyte |
WO2011084607A1 (en) * | 2009-12-17 | 2011-07-14 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
US20120188640A1 (en) * | 2009-07-20 | 2012-07-26 | Tufts University/Trustees Of Tufts College | All-protein implantable, resorbable reflectors |
US20120265038A1 (en) * | 2011-04-12 | 2012-10-18 | Panasonic Corporation | Method for measuring a concentration of a biogenic substance contained in a living body |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4645340A (en) * | 1983-06-01 | 1987-02-24 | Boston University | Optically reflective sphere for efficient collection of Raman scattered light |
US6438397B1 (en) * | 1999-10-28 | 2002-08-20 | Gerald G. Bosquet | Method and apparatus for analyte detection using intradermally implanted skin port |
DE10011284B4 (en) * | 2000-03-08 | 2007-06-28 | Disetronic Licensing Ag | Apparatus for in vivo measurement of the concentration of an ingredient of a body fluid |
CA2448681C (en) * | 2001-06-12 | 2014-09-09 | Pelikan Technologies, Inc. | Integrated blood sampling analysis system with multi-use sampling module |
DE102006020720A1 (en) * | 2006-05-04 | 2007-11-08 | Robert Bosch Gmbh | Interferometric measuring device for optical measurement on skin structures |
US7603151B2 (en) * | 2006-08-22 | 2009-10-13 | Bayer Healthcare Llc | Non-invasive methods of using spectral information in determining analyte concentrations |
WO2008143651A2 (en) * | 2006-12-07 | 2008-11-27 | The Ohio State University Research Foundation | A system for in vivo biosensing based on the optical response of electronic polymers |
-
2013
- 2013-12-23 GB GB1522844.8A patent/GB2531956A/en not_active Withdrawn
- 2013-12-23 GB GB1322953.9A patent/GB2521627A/en not_active Withdrawn
-
2014
- 2014-12-22 WO PCT/EP2014/079080 patent/WO2015097190A2/en active Application Filing
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995022927A1 (en) * | 1994-02-23 | 1995-08-31 | Peyman Gholam A | Diagnostic system and method using an implanted reflective device |
EP1129353A1 (en) * | 1999-09-10 | 2001-09-05 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analytes in vivo |
US20030225322A1 (en) * | 2001-11-22 | 2003-12-04 | Kenichi Uchiyama | Optical waveguide sensor, device, system and method for glucose measurement |
DE10212140A1 (en) * | 2002-03-19 | 2003-10-09 | Henry Arthur Muglia | Blood sugar sensor and measuring method for determining the blood sugar value |
US20040012788A1 (en) * | 2002-06-19 | 2004-01-22 | Omron Corporation | Method for measuring concentration of component contained in bodily fluid and apparatus for measuring concentration of component contained in bodily fluid |
JP2004159994A (en) * | 2002-11-14 | 2004-06-10 | Toshiba Corp | Apparatus and measuring method for reverse iontophoresis |
WO2004085995A2 (en) * | 2003-03-24 | 2004-10-07 | Rosedale Medical Inc. | Analyte concentration detection devices and methods |
US7236812B1 (en) * | 2003-09-02 | 2007-06-26 | Biotex, Inc. | System, device and method for determining the concentration of an analyte |
US20060198762A1 (en) * | 2005-03-04 | 2006-09-07 | Ikuo Uematsu | Optical glucose sensor chip |
US20120188640A1 (en) * | 2009-07-20 | 2012-07-26 | Tufts University/Trustees Of Tufts College | All-protein implantable, resorbable reflectors |
WO2011084607A1 (en) * | 2009-12-17 | 2011-07-14 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
US20120265038A1 (en) * | 2011-04-12 | 2012-10-18 | Panasonic Corporation | Method for measuring a concentration of a biogenic substance contained in a living body |
Also Published As
Publication number | Publication date |
---|---|
GB2531956A (en) | 2016-05-04 |
GB201522844D0 (en) | 2016-02-03 |
GB2521627A (en) | 2015-07-01 |
WO2015097190A2 (en) | 2015-07-02 |
GB201322953D0 (en) | 2014-02-12 |
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