WO2015076613A1 - Appareil de stimulation ultrasonore pour ajuster la température d'un organe interne d'un corps humain et procédé pour l'utiliser - Google Patents

Appareil de stimulation ultrasonore pour ajuster la température d'un organe interne d'un corps humain et procédé pour l'utiliser Download PDF

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Publication number
WO2015076613A1
WO2015076613A1 PCT/KR2014/011258 KR2014011258W WO2015076613A1 WO 2015076613 A1 WO2015076613 A1 WO 2015076613A1 KR 2014011258 W KR2014011258 W KR 2014011258W WO 2015076613 A1 WO2015076613 A1 WO 2015076613A1
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WIPO (PCT)
Prior art keywords
ultrasonic
human body
target organ
temperature
organ
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PCT/KR2014/011258
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English (en)
Korean (ko)
Inventor
서종범
김성배
박진감
손정우
원종호
조용준
송길수
차오름
김진호
Original Assignee
주식회사 퍼시픽시스템
연세대학교 원주산학협력단
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Publication of WO2015076613A1 publication Critical patent/WO2015076613A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system

Definitions

  • the present invention relates to an ultrasonic stimulation system, and more particularly, to increase the temperature of the internal organs through the ultrasound to adjust the balance of normal bacteria or to activate the activity and growth of normal bacteria to improve the function of the human body or disease It relates to an ultrasonic stimulation device for treating a method and a method of using the same.
  • Normal flora refers to the collection of all normal bacteria present in the body and is generally present in the skin, oral cavity, nasal cavity and digestive organs.
  • the normal bacteria present in the digestive organs of the normal bacteria group is called gut flora (gut flora) can be classified according to the digestive organs (stomach flora), intestinal flora (intestinal flora).
  • all normal bacteria are in a certain balance so that various nutrients can be absorbed by cells in the body. Therefore, if the balance of the normal bacteria group is broken, the disease may be caused in the human organ. For example, if the balance of enterococci present in the digestive tract is broken, it can cause diseases related to the digestive tract, such as indigestion, diarrhea, vomiting, and constipation.
  • the balance of normal bacteria can occur depending on various environmental factors such as temperature, humidity and Ph concentration. Particularly in the case of temperature, the reaction may be different even with very small changes.
  • the balance of the normal bacteria group is maintained firmly from 34 °C to 37 °C active activity of normal bacteria, on the contrary at 40 °C the balance of the normal bacteria group is easily destroyed, the activity is significantly reduced. Therefore, by properly adjusting the temperature of the human body to maintain the balance of normal bacteria can improve the function of the human body.
  • ultrasound can transmit energy to the deep part of the human body, it is suitable for stimulating an organ located in the deep part of the human body, and thus, a technology for stimulating the organ located in the deep part using ultrasound has been developed.
  • An object of the present invention for solving the above problems, by increasing the temperature of the internal organs through the ultrasound to adjust the balance of normal bacteria in the body or to activate the activity and growth of normal bacteria ultrasonic waves that can improve the function of the human body It is to provide a stimulation device.
  • Another object of the present invention by adjusting the depth of focus to be formed by the ultrasound to increase the temperature of the internal organs of the body by adjusting the balance of normal bacteria in the body or by activating the activity and growth of the normal bacteria group diseases caused in the internal organs of the human body It is to provide an ultrasonic stimulation method that can treat.
  • Ultrasonic stimulation apparatus for temperature control of the internal organs of the human body according to an aspect of the present invention for achieving the above object, the frequency of the ultrasonic wave (implemented) by the ultrasonic stimulation system and suitable for irradiation of the target organ (target organ) and
  • the main body generating the electrical signal and the electrical signal generated by the main body corresponding to the ultrasonic irradiation information including the depth of focus to be formed by the ultrasonic wave is converted into an ultrasonic signal, and the ultrasonic signal is irradiated to the target organ to It includes an ultrasonic output unit for inducing a temperature rise to adjust the balance of the normal bacteria group existing in the target organ or to activate the activity and growth of the normal bacteria group.
  • the ultrasound irradiation information may be adjusted so that the depth of focus to be formed by the ultrasound is formed within the range of 4 cm to 15 cm from the surface of the human body by adjusting the frequency of the ultrasound.
  • the ultrasonic output unit may irradiate the target organ with an ultrasonic signal so that the temperature of the target organ increases within 5 ° C. from the existing temperature of the target organ.
  • the ultrasonic output unit is irradiated with the ultrasonic signal to the digestive organ so as to remain within the digestive organ so as to rise within 5 ° C based on the existing temperature of the digestive organ. It is possible to treat constipation and diseases that may occur in the digestive tract by improving the digestive function of the human body by adjusting the balance of the intestinal bacteria correctly or activating the growth and activity of the intestinal bacteria.
  • the ultrasonic stimulation method for temperature control of the internal organs of the human body for achieving the above object is performed in the ultrasonic stimulation apparatus for temperature control of the internal organs of the human body, Generating an electrical signal corresponding to ultrasonic irradiation information including a frequency and a depth of focus to be formed by ultrasonic waves, converting the electrical signal into an ultrasonic signal, and inducing a temperature increase of the target organ to be present in the target organ Irradiating the target organ with an ultrasonic signal to control the balance of the group or to activate the activity and growth of the normal flora.
  • the ultrasonic stimulation apparatus for controlling the temperature of the internal organs of the human body and a method of using the same according to an embodiment of the present invention as described above, by adjusting the temperature of the internal organs through the ultrasound to control the balance of normal bacteria in the body or By activating the activity and growth can improve the function of the human body.
  • FIG. 1 is a block diagram showing an ultrasonic stimulation device for controlling the temperature of the internal organs of the human body according to an embodiment of the present invention.
  • FIG. 2 is an exemplary view illustrating a change in depth with respect to a focal point formed according to frequency adjustment of ultrasonic waves according to an embodiment of the present invention.
  • FIG 3 is an exemplary view illustrating an experimental result of measuring a change in temperature by irradiating ultrasonic waves to form a focus at a specific depth according to an embodiment of the present invention.
  • Figure 4 is a picture of the actual implementation of the ultrasonic stimulation device for temperature control of the internal organs of the human body according to an embodiment of the present invention.
  • Figure 5 is an exemplary view illustrating the results of clinical trials irradiated with ultrasound in the constipation patient according to an embodiment of the present invention.
  • FIG. 6 is a flowchart illustrating an ultrasonic stimulation method for temperature control of an internal organ of the human body according to an exemplary embodiment of the present invention.
  • first, second, A, and B may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another.
  • the first component may be referred to as the second component, and similarly, the second component may also be referred to as the first component.
  • FIG. 1 is a block diagram showing an ultrasonic stimulation device for controlling the temperature of the internal organs of the human body according to an embodiment of the present invention
  • Figure 2 is a depth of the focal point formed in accordance with the frequency control of the ultrasonic wave according to an embodiment of the present invention It is an exemplary view explaining a change.
  • FIG. 3 is an exemplary view illustrating an experimental result of measuring a change in temperature by irradiating ultrasonic waves to form a focal point at a specific depth according to an embodiment of the present invention
  • FIG. 4 is a diagram illustrating an internal human body according to an embodiment of the present invention.
  • Ultrasonic stimulation apparatus for the temperature control of the organ is a photograph actually implemented
  • Figure 5 is an exemplary view illustrating the results of clinical trials irradiated with ultrasound in the constipation patient according to an embodiment of the present invention.
  • the ultrasound stimulation apparatus 100 may be implemented by an ultrasound stimulation system.
  • the ultrasonic stimulation system refers to a system for treating a disease by irradiating ultrasound to stimulate specific organs of the human body.
  • the balance of normal bacteria in the body improves the function of the human body by maintaining the balance of normal bacteria by appropriately adjusting the temperature of organs inside the body as the response is sensitive to very small temperature changes.
  • the disease can be treated.
  • the conventional ultrasonic stimulation system has a problem that the depth of focus by the ultrasonic wave is limited to within about 1 cm to 3 cm, so that the internal organs of the human body cannot be stimulated.
  • the present invention proposes an ultrasonic stimulation device for improving the function of a human body or treating a disease by inducing ultrasonic temperature to the internal organs of the human body to induce a rise in temperature of the internal organs of the human body.
  • the ultrasonic stimulation apparatus 100 may include a main body 200 and an ultrasonic output unit 300.
  • the main body 200 may generate an electrical signal corresponding to ultrasonic irradiation information including a frequency of ultrasonic waves suitable for irradiation of a target organ and a depth of focus to be formed by the ultrasonic waves.
  • the main body 200 may adjust the ultrasonic irradiation information so that the depth of focus to be formed by the ultrasonic waves is adjusted within the range of 4 cm to 15 cm from the surface of the human body by adjusting the frequency of the ultrasonic waves.
  • the depth of focus formed according to the frequency of ultrasound may be checked.
  • the focus 21 may mean a point at which energy is transmitted efficiently in the ultrasonic irradiation. That is, the efficient energy transfer may mean that the thermal effect of accumulating the attenuated energy in the body through the scattering and absorption of ultrasonic waves irradiated to the internal organs of the human body may be efficiently generated. This can induce a rise in the temperature of the internal organs of the human body.
  • the frequency of 500kHz is irradiated, it has a size 23 of about 1 cm as shown in the photograph of FIG. 2A, and starts to form at a depth of about 20 mm from the start of ultrasonic irradiation, and about 60 mm to a depth of about 90 mm.
  • a focal point 21 can be formed in which 25 can be irradiated.
  • a result of measuring a depth at which ultrasonic energy can be efficiently transmitted through the sound field measurement system can be confirmed by examining the frequency of 500 kHz.
  • an ultrasound wave having a frequency of 500 kHz may form a focal point 21 at a depth of about 2 cm to about 9 cm from the skin of the abdomen where the irradiation of the ultrasound has started, and a focal point ranging from about 2 cm to about 9 cm ( Among the depths of 21), it can be seen that energy transfer is most efficient, especially at a depth of about 3 cm.
  • a focal point 21 can be formed in which can be irradiated.
  • ultrasound having a frequency of 1 MHz confirms that energy transfer is most efficient at a depth of about 6 cm among the depths of the focus 21 ranging from about 4.5 cm to about 12 cm or more. Can be.
  • the frequency of 4MHz When the frequency of 4MHz is irradiated, it has a size 23 of about 0.6 cm as shown in the photograph of FIG. 2C, and starts to form at a depth of about 180 mm and can be irradiated with a depth 25 of about 220 mm or more to a depth of about 400 mm or more. Focus 21 can be formed.
  • ultrasound having a frequency of 4 MHz confirms that energy transfer is most efficient at a depth of about 27.5 cm among the depths of the focus 21 ranging from about 18 cm to about 40 cm or more. Can be.
  • the size of the focal point to prevent the damage of the normal bacteria due to the temperature of the abdominal skin and subcutaneous fat is about 3 ⁇ 4 cm or more, and to increase the temperature of the local area of the internal organs of the human body and to stimulate the specific area only.
  • a suitable frequency of 500 kHz can be used, which allows the depth of focus to be formed within a range of 4 cm to 15 cm.
  • the ultrasonic output unit 300 converts the electrical signal generated by the main body 200 into an ultrasonic signal, and irradiates the converted ultrasonic signal to the target organ to induce a rise in temperature of the target organ, thereby maintaining the normal bacteria group present in the target organ.
  • the balance can be adjusted or the activity and growth of normal flora can be activated.
  • the ultrasound output unit 300 may irradiate the target organ with an ultrasonic signal such that the temperature of the target organ increases within 5 ° C. from the existing temperature of the target organ.
  • the reason why the temperature rise of the target organ is limited to within 5 ° C. in the present invention is that a temperature rise of 6 ° C. or more may rather destroy the balance of normal bacteria existing in the target organ or become a low temperature burn condition.
  • the ultrasonic wave when the ultrasonic wave is irradiated using the ultrasonic stimulation device 100 according to the present invention, it can be induced to rise to within 5 °C based on the existing temperature of the target organ.
  • This increase in temperature can control the balance of normal bacteria present in target organs, or activate the activity and growth of normal bacteria, and improve or function the target organs through balancing and activating normal bacteria.
  • Various diseases can be treated.
  • the ultrasound signal is irradiated to the digestive organs so as to be formed within the range of 4 cm to 15 cm from the surface of the human body by using ultrasonic waves having a frequency of 500 kHz. can do.
  • a temperature rise within 5 ° C may be induced based on the existing temperature of the digestive organs, and due to the increase in the temperature of the digestive organs due to ultrasound irradiation, the balance of enterobacteria present in the digestive organs may be properly maintained, Growth can be activated to improve the body's digestive function.
  • the ultrasound stimulation apparatus 100 actually implemented as shown in FIG. 4 was used, and the position of the ultrasound stimulation of the ultrasound target group having constipation was commonly set to the lower part of the small intestine and the rectum area.
  • Ultrasound was irradiated through the ultrasonic output unit 300 in the vicinity of the lower 4 ⁇ 6 cm.
  • constipation alleviation methods such as fibrin intake and exercise amount, laxative administration or enema for the treatment of constipation.
  • the ultrasonic stimulation device increases the temperature of the digestive organ in a non-invasive manner, it is expected to be a new treatment that can alleviate constipation more efficiently than before.
  • infertility in women is often caused by the cold of the uterus, so that the function can be improved by raising the temperature by irradiating the uterus with the ultrasonic stimulation apparatus 100.
  • the ultrasonic stimulation apparatus 100 may be used to increase the effect of lipolysis by increasing the body temperature before exercise.
  • FIG. 6 is a flowchart illustrating an ultrasonic stimulation method for temperature control of an internal organ of the human body according to an exemplary embodiment of the present invention.
  • the ultrasonic stimulation method for controlling the temperature of an internal organ of a human body may include generating an electrical signal in response to ultrasonic irradiation information suitable for irradiation of a target organ (S100), and converting the electrical signal into an ultrasonic signal ( S200 and the ultrasound signal may be irradiated to the target organ (S300).
  • the electrical signal may be generated according to the ultrasound irradiation information including the frequency of ultrasound suitable for irradiation of the target organ and the depth of focus to be formed by the ultrasound (S100).
  • the ultrasound irradiation information may be adjusted so that the depth of the focal point to be formed by the ultrasound is formed within the range of 4 cm to 15 cm from the surface of the human body by adjusting the frequency of the ultrasound.
  • the thickness of the skin and subcutaneous fat of the abdomen is about 3-4 cm or more, and in order to prevent damage to the normal bacteria caused by temperature rise and local irritation of specific areas of the internal organs of the human body.
  • a frequency of 500 kHz may be used in that the size of ⁇ should be wide, thereby allowing the depth of focus to be formed within the range of 4 cm to 15 cm.
  • an electrical signal such that the depth of focus is formed within a range of 4 cm to 15 cm through a frequency of 500 kHz may be converted into an ultrasonic signal (S200).
  • Piezoelectric crystal elements of various materials may be used for the conversion of the ultrasonic signal, but the present invention is not limited thereto.
  • the ultrasound signal converted to induce a temperature increase of the target organ may be irradiated to the target organ (S300).
  • normal activity and growth of the normal bacteria group can improve the function of the target organ or treat various diseases that can occur in the target organ.
  • the ultrasound signal is irradiated to the digestive organs so as to be formed within the range of 4 cm to 15 cm from the surface of the human body by using ultrasonic waves having a frequency of 500 kHz. can do.
  • a temperature rise within 5 ° C may be induced based on the existing temperature of the digestive organs, and due to the increase in the temperature of the digestive organs due to ultrasound irradiation, the balance of enterobacteria present in the digestive organs may be properly maintained, Growth can be activated to improve the body's digestive function.
  • the ultrasonic stimulation method as described above may be extended to various methods that can be worn on the human body, such as a belt but not limited to irradiating ultrasonic waves by massaging the human body.

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Abstract

L'invention concerne un appareil de stimulation ultrasonore et un procédé pour ajuster la température d'un organe interne d'un corps humain. L'appareil de stimulation ultrasonore comprend : une partie corps pour produire un signal électrique en correspondance avec l'information de rayonnement ultrasonore comprenant la fréquence d'une onde ultrasonore pour rayonner sur un organe ciblé et la profondeur du foyer à former par l'onde ultrasonore ; et une partie de production d'ultrasons pour convertir le signal électrique produit par la partie corps en un signal ultrasonore et irradier le signal ultrasonore sur l'organe ciblé pour induire une augmentation de température de l'organe ciblé de façon à ajuster l'équilibre d'un groupe de bactéries normal toujours présent dans l'organe ciblé ou activer l'activité et la croissance du groupe de bactéries normal. Ainsi, la présente invention peut améliorer la fonction du corps humain ou traiter une maladie apparue dans les organes internes du corps humain.
PCT/KR2014/011258 2013-11-21 2014-11-21 Appareil de stimulation ultrasonore pour ajuster la température d'un organe interne d'un corps humain et procédé pour l'utiliser WO2015076613A1 (fr)

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KR20130142205 2013-11-21
KR10-2013-0142205 2013-11-21

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100895939B1 (ko) * 2005-01-18 2009-05-07 알마 레이저스 엘티디 무선주파수 에너지를 통한 생물학적 조직 가열 방법 및개선된 시스템
KR20110059364A (ko) * 2009-11-27 2011-06-02 박인숙 마이크로파 온열치료기
US20110178441A1 (en) * 2008-07-14 2011-07-21 Tyler William James P Methods and devices for modulating cellular activity using ultrasound
KR20110010059U (ko) * 2010-04-19 2011-10-26 주식회사 퍼시픽시스템 초음파 자극기 및 시스템
KR20130019971A (ko) * 2011-08-18 2013-02-27 조동식 초음파에 의한 신체 일부의 온열 방법 및 초음파 온열 자극기

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100895939B1 (ko) * 2005-01-18 2009-05-07 알마 레이저스 엘티디 무선주파수 에너지를 통한 생물학적 조직 가열 방법 및개선된 시스템
US20110178441A1 (en) * 2008-07-14 2011-07-21 Tyler William James P Methods and devices for modulating cellular activity using ultrasound
KR20110059364A (ko) * 2009-11-27 2011-06-02 박인숙 마이크로파 온열치료기
KR20110010059U (ko) * 2010-04-19 2011-10-26 주식회사 퍼시픽시스템 초음파 자극기 및 시스템
KR20130019971A (ko) * 2011-08-18 2013-02-27 조동식 초음파에 의한 신체 일부의 온열 방법 및 초음파 온열 자극기

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