WO2015062208A1 - 全自动粪便分析仪 - Google Patents

全自动粪便分析仪 Download PDF

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Publication number
WO2015062208A1
WO2015062208A1 PCT/CN2014/075231 CN2014075231W WO2015062208A1 WO 2015062208 A1 WO2015062208 A1 WO 2015062208A1 CN 2014075231 W CN2014075231 W CN 2014075231W WO 2015062208 A1 WO2015062208 A1 WO 2015062208A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
needle
stool
cleaning
sample box
Prior art date
Application number
PCT/CN2014/075231
Other languages
English (en)
French (fr)
Inventor
李降龙
Original Assignee
苏州海路生物技术有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201320677151.1U external-priority patent/CN203535060U/zh
Priority claimed from CN201310529437.XA external-priority patent/CN104597265A/zh
Application filed by 苏州海路生物技术有限公司 filed Critical 苏州海路生物技术有限公司
Priority to JP2016526263A priority Critical patent/JP6290395B2/ja
Priority to EP14859130.8A priority patent/EP3064948B1/en
Priority to US15/033,105 priority patent/US10605815B2/en
Priority to RU2016120584A priority patent/RU2662301C2/ru
Publication of WO2015062208A1 publication Critical patent/WO2015062208A1/zh
Priority to US16/792,138 priority patent/US11293933B2/en
Priority to US17/677,832 priority patent/US20220178956A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00108—Test strips, e.g. paper
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents

Definitions

  • the invention relates to a hospital testing instrument, in particular to a fully automatic stool analyzer. Background technique
  • Human feces is a mixture of undigested food, unabsorbed food residue and digestive system secretions, digestive tract mucosal exfoliation, and microorganisms, parasites, etc. Systematic functions, pathological changes, and information on microbial and parasitic infections, so stool testing (including physical testing and chemical testing) is one of the three routine tests performed by hospitals on patients. At present, hospital stool testing is usually a manual test, which relies mainly on the proficiency and personal experience of the testing physician, thus having a certain impact on the test results, which does not reflect the true state of the test; and is not hygienic during the test. .
  • the Chinese invention patent specification CN101487845B discloses an automatic detector for stool specimens, including an automatic controller; a specimen box for amplifying the specimen; a dilution device for adding a quantitative diluent to the stool specimen; a mixing device for uniformly mixing the diluted stool sample; a detecting unit for detecting the stool specimen, comprising a physical detecting unit and a chemical detecting unit, wherein the physical detecting unit comprises a counting pool, and the chemical detecting unit comprises Chemical testing room; sample and cleaning device.
  • the stool specimen automatic detector automatically performs quantitative dilution, agitation mixing, aspirating sample detection, and cleaning, which reduces contact with the outside and reduces environmental and laboratory contamination.
  • the present invention provides a fully automatic stool analyzer comprising the following parts: an automatic controller;
  • At least one sample box for containing a stool specimen; a sample cartridge holder for placing a sample cartridge;
  • a dilution agitation unit for adding a diluent to the stool sample in the sample box and stirring to obtain a stool sample solution
  • a physical detection unit for physically detecting the stool sample solution
  • At least one chemical detecting unit for chemically detecting the stool sample liquid, each chemical unit comprising a driving roller and a driven roller, wherein the driven roller is wound with a reagent strip, and the end of the reagent strip is fixed at the active On the drum, the reagent strip roll comprises a plurality of reagent strips distributed side by side and connected in sequence;
  • the sample aspirating unit is configured to suck the stool sample solution and feed the stool sample solution into the physical detecting unit and the chemical detecting unit.
  • the sample cartridge holder is provided with a plurality of openings facing upward and for placing a cavity of the sample cartridge, wherein the inner wall of the cavity is provided with an elastic clamping member, and the sample cartridge is placed in the cavity. Thereafter, the sample box is in surface contact with the elastic clamping member and is an interference fit.
  • a barcode scanner is further disposed on the rear side of the sample box with a barcode
  • a barcode scanning port disposed opposite to the sample box is disposed on the rear side of the sample box holder, and the barcode scanner scans through the barcode scanning port. The barcode on the sample box.
  • the utility model further comprises a trait camera, wherein the front side of the sample box holder is provided with a trait photographing port disposed opposite to the sample box, and the trait camera takes the fecal specimen in the sample box through the trait photographing port.
  • the aspirating sample loading unit includes a first robot that is located at the physical detecting unit and movable up and down, and a second robot that is located at the chemical detection detecting unit and movable up, down, left and right, and back and forth, the first robot a first suction needle is disposed, the first suction needle is connected to the first peristaltic pump, and the physical detection unit comprises a counting pool connected in series between the first suction needle and the first peristaltic pump; a second suction needle is disposed on the second robot, the second suction needle is connected to the second peristaltic pump, and the reagent strip is provided with a sample application area and a convex portion disposed opposite to the sample application area, and chemical detection The second needle penetrates the boss.
  • the reagent strip is a plastic strip, comprising a pallet, a cover plate and a test strip, wherein the pallet and the cover are both formed by a plastic film, and the edges of the pallet and the cover are plastically sealed together, The test strip is sealed between the pallet and the cover.
  • first peristaltic pump and the second peristaltic pump are both connected to the cleaning liquid tank, the cleaning liquid barrel is provided with a cleaning liquid; the first mechanical hand is provided with a first cleaning needle, and the first cleaning needle passes The first cleaning pump is connected to the cleaning liquid tank, the end of the first cleaning needle extends to the outer wall of the first suction needle; the second mechanical hand is provided with a second cleaning needle, and the second cleaning needle passes the The second cleaning pump is connected to the cleaning liquid tank. The end of the second cleaning needle extends to the outer wall of the second suction needle.
  • the dilution stirring unit includes a third robot that can move up and down, the third robot is provided with a stirring motor and a liquid adding needle, and the sample box is provided with a rotatable sampling spoon, when the third robot is lowered
  • the output shaft of the stirring motor is coaxially connected with the sampling spoon, and the liquid adding needle is inserted into the sample box.
  • the liquid adding needle is connected to a dilution liquid tank through a third peristaltic pump, and the dilution liquid tank is filled with a diluent.
  • the chemical detection unit has 5 to 7, and the reagent strip detection items in each chemical detection unit are different, and the plurality of chemical detection units are arranged side by side.
  • the method further includes a photoelectric positioning switch located above the reagent strip, the active roller is connected to the step-by-step motor, and the photoelectric positioning switch and the stepping motor are all connected with the automatic controller.
  • the automatic feces analyzer of the present invention has the following beneficial effects:
  • the automatic fecal analyzer can automatically perform continuous physical and chemical detection on a plurality of fecal specimens, and the detection efficiency is very high, and in addition, The chemical detection of the stool specimen is completed by using the reagent strip, so the detection cost is low, and it is suitable for popularization and application.
  • Figure 1 is a schematic view of the structure of the present invention (the figure is a plan view).
  • FIG. 2 is a schematic structural view of the sample cartridge holder and the sample cartridge of FIG. 1.
  • Figure 3 is a rear view of Figure 2.
  • Figure 4 is a front view of Figure 2.
  • Fig. 5 is a cross-sectional view taken along line A-A of Fig. 1;
  • Figure 6 is a cross-sectional view taken along line B-B of Figure 1.
  • Figure 7 is a cross-sectional view taken along line C-C of Figure 1.
  • Figure 8 is a pipe connection diagram of the physical detection unit.
  • Figure 9 is a piping connection diagram of the chemical detection unit.
  • Figure 10 is a schematic view showing the structure of a reagent strip in the present invention.
  • Figure 11 is a schematic view showing the structure of a reagent strip in the present invention.
  • Component label description is a schematic view showing the structure of a reagent strip in the present invention.
  • the present invention provides a fully automatic stool analyzer, comprising the following parts: an automatic controller;
  • Sample box holder 2 used for placing the sample box 1;
  • the dilution stirring unit 3 is configured to add a diluent to the stool sample in the sample box 1 and stir to obtain a stool sample solution;
  • a physical detection unit for physically detecting the stool sample solution
  • At least one chemical detecting unit 4 for performing chemical detection on the stool sample liquid each chemical unit including a driving roller 41 and a driven roller 42.
  • the driven roller 42 is wound with a reagent strip 43
  • the end of the reagent strip 43 is fixed on the driving roller 41, and the reagent strip 43 includes a plurality of The reagent strips 44 are arranged side by side, and are sequentially connected.
  • the sample aspirating unit 7 is used for sucking the stool sample solution, and the stool sample solution is sent to the physical detection unit and the chemical detection unit 4.
  • the stool sample is collected and stored in the sample box 1, and then the sample box 1 is sent to the analyzer through the sample box holder 2 to be diluted and stirred, and then the stool sample liquid is transported through the sample sample loading unit 7.
  • Physical detection is performed at the physical detection unit, and is sent to the chemical detection unit 4 for chemical detection.
  • the chemical detection unit 4 a plurality of reagent strips 44 are sequentially connected, thereby continuously detecting a plurality of stool specimens, thereby greatly improving detection. effectiveness.
  • the reagent strips 44 are used for chemical detection of feces, further reducing the cost of detection.
  • the push-in robot, the transfer robot and the push-out robot connected to the sample cartridge holder 2 are further included, and the push-in robot, the transfer robot, and the push-out robot are stepwise drives, that is, three sets of stepper motors are used in a straight line.
  • the feed mechanism is used to move the sample cartridge holder 2; wherein, the push-in robot is used to push the sample cartridge holder 2 into the analyzer, and the transfer robot is used to sequentially transfer the sample cartridge holder 2 to the dilution stirring unit 3 and the physical detection unit. After the completion of all the tests, the ejection robot moves the sample cartridge holder 2 out of the analyzer.
  • the chemical detection unit 4 has 5 to 7, and the detection items of the reagent strips 44 in each of the chemical detection units 4 are different, and the plurality of chemical detection units 4 are distributed side by side, and the plurality of chemical detection units 4 are used. Simultaneously carry out different chemical tests on the stool specimens, such as reagent strips 43 of Fob, rotavirus and Helicobacter pylori, in the case of chemical detection, the sample sample solution to be aspirated by the sample-feeding unit 7 The three specimens of the reagent strips 44 were respectively dropped, and the fecal specimens were simultaneously tested for Fob, rotavirus, and Helicobacter pylori.
  • two spare chemical detecting units 4 are further included, and the two chemical detecting units 4 are not equipped with the reagent strips 43 and are spare reagent bits; when the detecting personnel starts to work, if the Fob reagent strips are found With only 80 remaining (ie 80) and 300 fecal specimens for Fob testing, the Fob reagent strip can be installed in either of the two spare chemical testing units 4 to complete all feces.
  • the Fob test of the specimen if the tester turns on the Fob reagent strip in the analyzer for 500 people, the test can be performed immediately, without using the spare chemical detection unit 4, and there is no need to stop the reagent or change during the test. specimen.
  • the sample cartridge holder 2 is provided with a plurality of openings 21 facing upwards and for placing the sample cartridge 1 , and the cavity 21 is matched with the sample cartridge 1 , the cavity
  • the inner wall of the 21 is provided with an elastic clamping member 22, and after the sample cartridge 1 is placed in the cavity 21, the sample cartridge 1 is in surface contact with the elastic clamping member 22, And the interference fit, thereby fixing the sample box 1 in the cavity 21 to prevent the sample box 1 from moving, swaying, cheap, etc.; at the same time, the outer wall of the sample box 1 is in surface contact with the inner wall of the elastic holding member 22.
  • the contact area between the two is increased to ensure the centering effect of the sample cartridge 1, thereby ensuring smooth loading, stirring, and aspirating of the specimen in the sample cartridge 1.
  • the elastic clamping members 22 are respectively disposed at the upper end and the lower end of the cavity 21, and the elastic clamping member 22 is made of a material having a high elastic modulus, such as aramid fiber or polyethylene fiber. , high modulus glass fiber, high modulus carbon fiber, etc., to increase the wear resistance of the elastic clamping member 22, prolong the service life of the elastic clamping member 22, thereby prolonging the service life of the entire sample cartridge holder 2.
  • a barcode scanner 5 is further included.
  • the rear side of the sample cartridge 1 is affixed with a barcode.
  • the rear side of the sample cartridge holder 2 is provided with a barcode scanning port 23 disposed opposite to the sample cartridge 1, as shown in FIG. 2 and FIG. 3.
  • the barcode scanning port 23 communicates with the cavity 21 and extends upward through the sample cartridge holder 2, and the barcode scanner 5 scans the barcode on the sample cartridge 1 through the barcode scanning port 23.
  • a trait photographer 6 is further included.
  • the front side of the sample cartridge holder 2 is provided with a photo taking port 24 disposed opposite to the sample cartridge 1. Referring to FIG. 2 and FIG. 4, the photographic photo port 24 is connected to the cavity 21.
  • the trait detector 6 captures the stool specimen in the sample cartridge 1 through the trait photographing port 24 to observe the shape and color of the stool specimen.
  • the barcode scanner 5 and the trait camera 6 are distributed back and forth along the moving direction of the sample cartridge holder 2, so that when the delivery robot transports the sample cartridge holder 2, the sample cartridge 1 located in the sample cartridge holder 2 passes through the barcode scanner 5 first. , to read the patient information, and store the subsequent detection results in the information directory of the barcode; and then pass through the trait camera 6, the dilution stirring unit 3 and the physical detection unit.
  • the dilution stirring unit 3 includes a third robot 31 that is movable up and down, and the third robot 31 is provided with a stirring motor 32 and a liquid adding needle 33.
  • the rotatable sampling spoon when the third robot 31 is lowered, the output shaft of the stirring motor 32 is coaxially connected with the sampling spoon, and the liquid adding needle 33 is inserted into the sample cartridge 1.
  • the liquid adding needle 33 is connected to a dilution liquid tank through a third peristaltic pump, and the dilution liquid tank is filled with a diluent.
  • the structure of the sample cartridge 1 can be referred to the Chinese utility model patent CN202735110U; the connection structure of the sample cartridge 1 and the stirring motor 32 can be referred to the Chinese invention patent CN101487845B.
  • the transfer robot transports the sample cartridge holder 2 to the dilution agitation unit 3, and the sample cartridge 1 on the sample cartridge holder 2 is located below the liquid addition needle 33; when the third robot hand 31 moves down, the input shaft of the agitation motor 32 and the sampling spoon Coaxial connection, and the liquid adding needle 33 is inserted into the sample box 1; when the third peristaltic pump rotates, the diluent enters the sample box 1 through the liquid adding needle 33; the stirring motor 32 rotates, drives the sampling spoon to rotate, and then completes the stool sample Quantitative dosing dilution and reasonable agitation.
  • the aspirating sample loading unit 7 includes a first robot 71 located at the physical detecting unit and movable up and down, and a second robot located at the chemical detecting detecting unit and movable up and down, left and right, and back and forth.
  • the first robot 71 is provided with a first suction needle 73
  • the first suction needle 73 is connected with the first peristaltic pump 74
  • the physical detection unit includes a series connection in the first suction a counting pool 8 between the sample needle 73 and the first peristaltic pump 74
  • a second suction needle 75 is disposed on the second robot hand 72, and the second suction needle 75 and the second peristaltic pump 76 are connected, see 9.
  • the reagent strip 44 is provided with a sample application area 441 and a convex portion 442 disposed opposite to the sample application area 441. See FIG. 10, the second sample needle penetrates the convex portion 442 during chemical detection.
  • the second robot 72 is a three-dimensional robot that can move 800 mm in the X direction, 300 mm in the Y direction, and 100 mm in the Z direction.
  • the present invention designs the reagent strip 44 as a plastic strip 81 from the cost of lowering the strip 44.
  • the strip 16 includes a plate 443 and a cover 444.
  • the test strip 445, the support plate 443 and the cover plate 444 are each formed of a plastic film, and the edges of the support plate 443 and the cover plate 444 are molded together, and the test strip 445 is sealed on the support plate 443 and the cover plate 444.
  • a detection zone 446 is further disposed on the test strip 445.
  • the support plate 443 and the cover plate 444 are both formed by a plastic sealing film, which effectively reduces the manufacturing cost of the reagent strip 44 and improves economic efficiency.
  • the edges of the plate 443 and the cover 444 are molded together, and the test strip 445 is sealed between the plate 443 and the cover 444, thereby effectively ensuring the dryness of the reagent strip 44, thereby allowing the reagent strip 44 to be exposed for a long time.
  • the adjacent two plastic strips 44 are connected by a tear line, which facilitates the tearing of the individual plastic strips 44 and can be used separately to meet the needs of different occasions.
  • the sample box 1 containing the stool sample solution is located below the first sample needle 73, and the first robot 71 is moved down, the first sample needle 73 is inserted into the sample box 1, and the first peristaltic pump 74 is positive.
  • the stool sample liquid is sucked from the sample box 1 and enters the counting pool 8 through the first suction needle 73 for microscopic detection;
  • the microscopic inspection module has a pre-focusing function, and the counting pool 8 can be horizontally oriented. Multi-point shift.
  • the second robot 72 moves, the second suction needle 75 is inserted into the sample cartridge 1, and the second peristaltic pump 76 is rotated forward, and the stool sample liquid is sucked from the sample cartridge 1 into the second suction needle 75;
  • the second robot 72 moves again, the second suction needle 75 is inserted into the convex portion 442 on the reagent strip 44, and the second peristaltic pump 76 is reversed, and the fecal specimen droplet in the second suction needle 75 is in the reagent strip.
  • Chemical application is performed on the sample application area 441 of 44.
  • the second robot 72 is provided with a camera for taking pictures of the reacted reagent strips 44, and the automatic controller controls an interpretation software to interpret the acquired photos, and makes a qualitative conclusion, thereby obtaining a conclusion.
  • Chemical detection results thus preventing errors caused by manual interpretation, improving detection accuracy and speed, It is now fully automatic.
  • a photoelectric sensor is disposed at the physical detecting unit for confirming the position of the sample cartridge 1.
  • the cleaning structure is as follows: As shown in FIG. 8 and FIG. 9, the first peristaltic pump 74 and the second peristaltic pump 76 are both connected to the cleaning liquid tank 77, and the cleaning liquid tank 77 is filled with the cleaning liquid; The first robot 71 is provided with a first cleaning needle 78. The first cleaning needle 78 is connected to the cleaning liquid tank 77 through a first cleaning pump 79. The end of the first cleaning needle 78 extends to the first suction needle.
  • the second mechanical hand 72 is provided with a second cleaning needle 710, and the second cleaning needle 710 is connected to the cleaning liquid tank 77 through the second cleaning pump 711, and the end of the second cleaning needle 710 is extended. To the outer wall of the second suction needle 75.
  • the first peristaltic pump 74 is reversed, the cleaning liquid in the cleaning liquid tank 77 is sucked, and enters the first suction needle 73 through the counting pool 8, thereby cleaning the counting pool 8 and the first sampling needle 73.
  • the second peristaltic pump 76 is reversed, the cleaning liquid in the cleaning liquid tank 77 is sucked into the second suction needle 75, and the inner wall of the second suction needle 75 is further cleaned; the second cleaning pump 711 is rotated and cleaned.
  • the liquid is sucked by the second cleaning needle 710 and flows down the outer wall of the second suction needle 75, thereby washing the outer wall of the second suction needle 75.
  • the waste liquid after cleaning the first sample suction needle 73 and the second suction sample needle 75 flows into a waste liquid barrel to facilitate centralized discharge of the waste liquid, and a liquid level switch is arranged in the waste liquid barrel for the upper alarm, that is, When the liquid level in the waste liquid tank is higher than the liquid level switch, the liquid level switch is triggered, and the automatic control controller issues an alarm according to the trigger signal.
  • the diluent tank and the cleaning liquid tank 77 are also provided with a liquid level switch for the lower position alarm, that is, when the liquid level of the diluent in the dilution liquid tank is lower than the liquid level switch or when cleaning in the cleaning liquid tank 77 When the liquid level is lower than the level switch, the level switch is triggered and the automatic controller issues an alarm based on the trigger signal.
  • the automatic controller controls the first peristaltic pump 74, the second peristaltic pump 76, the first cleaning pump 79, and the second cleaning pump 711 to perform a gap rotation when cleaning the first aspiration needle 73 and the second aspiration needle 75. Therefore, a cleaning liquid, a section of air, a section of cleaning liquid, a section of air are distributed in the cleaning pipe, and the cleaning liquid is sent out by the gap, and the pressure in the pipe increases under the action of the air, so that the cleaning liquid is blasted.
  • the inner wall and the outer wall of the first suction needle 73 and the inner wall and the outer wall of the second suction needle 75 are flushed in a manner to have a large flushing force, thereby ensuring a cleaning effect.
  • a photoelectric positioning switch 9 is disposed above the reagent strip 44, and the driving roller 41 Connected to a stepping motor, the photoelectric positioning switch 9 and the stepping motor are all connected with an automatic controller; the stepping motor drives the driving roller 41 to step by step, and under the action of the photoelectric positioning switch 9, Each time the roller is rotated, the reagent strip roll 43 is advanced once in units of one reagent strip 44.
  • the automatic feces analyzer pushes the robot to stay at the forefront of the instrument before the work, the transfer robot stays at the leftmost side of the instrument, the third robot 31 stays at the top, and the first robot 71 stays at the physical detection unit.
  • the second robot 72 stays at the top of the reagent strip 44, the reagent cartridge stays in the initial position or the memory position, and the push-out robot stays at the rear end of the instrument.
  • a plurality of sample boxes 1 are manually placed in the sample box holder 2, and each sample box 1 contains a stool sample of a different patient.
  • the push-in robot pushes the sample box holder 2 into the sample box.
  • the analyzer in the perspective of the view of Fig.
  • the sample cartridge holder 2 enters the instrument from front to back; when the sample cartridge holder 2 hits the limit switch 10 at the rear end of the instrument, the push-in robot stops moving, and the transfer robot will
  • the sample cartridge holder 2 is laterally transported from right to left in a stepwise manner, and sequentially passes through the barcode scanner 5, the trait camera 6, the dilution agitation unit 3, and the physical detection unit; in the process of continuous stepwise transmission, located in the physical detection unit
  • the stool sample solution is physically and chemically tested, and the stool specimen located at the dilution and agitation unit 3 is diluted and stirred, so that the instrument continuously detects a plurality of different stool specimens at a speed of up to 120 per hour.
  • a stool specimen which greatly improves the detection efficiency.
  • the apparatus is further provided with a computer and a printer for printing the test result of a stool specimen.
  • the present invention effectively overcomes various shortcomings in the prior art and has high industrial utilization value.
  • the above-described embodiments are merely illustrative of the principles of the invention and its advantages, and are not intended to limit the invention. Any of the above-described embodiments may be modified or altered without departing from the spirit and scope of the invention. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and scope of the invention will be

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Abstract

一种全自动粪便分析仪，包括以下部分：自动控制器；至少一个样本盒（1），用于盛放粪便标本；样本盒支架（2），用于放置样本盒（1）；稀释搅拌单元（3），用于对样本盒（1）内的粪便标本加稀释液并搅拌，得到粪便标本液；物理检测单元，用于对粪便标本液进行物理检测；至少一个化学检测单元（4），用于对粪便标本液进行化学检测，每个化学检测单元（4）包括主动滚筒（41）和从动滚筒（42），从动滚筒（42）上缠绕有试剂条卷（43），该试剂条卷（43）的端部固定在主动滚筒（41）上，试剂条卷（43）包括多个并排分布、且依次相连的试剂条（44）；吸样加样单元（7），用于吸取粪便标本液，并将粪便标本液送入所述物理检测单元和化学检测单元（4）。该全自动粪便分析仪能够自动对多个粪便标本进行连续的物理检测和化学检测，其检测效率非常高。

Description

全自动粪便分析仪
技术领域
本发明涉及一种医院用检测仪器， 特别是涉及一种全自动粪便分析仪。 背景技术
人体粪便是一种由未消化的食物、 经消化后未吸收的食物残渣与消化系统分 泌物、 消化道粘膜脱落物以及微生物、 寄生虫等组成的混合物， 对人体粪便进行 检测可获得检测者消化系统功能、 病理变化以及微生物和寄生虫感染等信息， 故 粪便检测 （包括物理检测和化学检测） 是医院对病人所做的三大常规检测之一。 目前， 医院粪便检测通常为人工检测， 其主要依靠检验医师的熟练程度和个人经 验， 从而对检验结果产生一定的影响， 不能很好的反映检测的真实情况； 且在检 测过程中， 很不卫生。
为了解决上述问题， 中国发明专利说明书 CN101487845B公开了一种大便标 本自动检测仪， 包括自动控制器； 标本盒， 用于盛放大便标本； 稀释装置， 用于 向大便标本中加入定量稀释液； 搅拌混匀装置， 用于将稀释后的大便标本搅拌均 匀； 检测单元， 用于对大便标本进行检测， 包括物理检测单元和化学检测单元， 所述物理检测单元包括计数池， 所述化学检测单元包括化学检测室； 吸样及清洗 装置。 该大便标本自动检测仪能够自动进行定量稀释、 搅拌混匀、 吸样检测、 以 及清洗， 其减少了与外部接触的环节， 降低对环境和实验室的污染。 但是， 其只 通过化学检测室对大便标本进行化学检测， 化学检测成本较高， 且仍需要操作人 员进行观察判读， 效率非常低， 不利于对多个大便标本进行检测， 或对一个大便 标本进行多项化学检测。 发明内容
鉴于以上所述现有技术的缺点， 本发明的目的在于提供一种成本低且检测效 率高的全自动粪便分析仪。
为实现上述目的， 本发明提供一种全自动粪便分析仪， 包括以下部分： 自动控制器；
至少一个样本盒， 用于盛放粪便标本； 样本盒支架， 用于放置样本盒；
稀释搅拌单元， 用于对样本盒内的粪便标本加稀释液并搅拌， 得到粪便标本 液；
物理检测单元， 用于对粪便标本液进行物理检测；
至少一个化学检测单元， 用于对粪便标本液进行化学检测， 每个化学单元包 括主动滚筒和从动滚筒， 所述从动滚筒上缠绕有试剂条卷， 该试剂条卷的端部固 定在主动滚筒上， 所述试剂条卷包括多个并排分布、 且依次相连的试剂条；
吸样加样单元， 用于吸取粪便标本液， 并将粪便标本液送入所述物理检测单 元和化学检测单元。
优选地，所述样本盒支架上开设有多个开口朝上、且用于放置样本盒的容腔， 所述容腔的内壁上设有弹性夹持件， 所述样本盒放入容腔中后， 样本盒与弹性夹 持件为面接触、 且为过盈配合。
进一步地， 还包括一条形码扫描器， 所述样本盒的后侧贴有条形码， 所述样 本盒支架后侧开设有与样本盒相对设置的条形码扫描口， 所述条形码扫描器通过 条形码扫描口扫描样本盒上的条形码。
优选地， 还包括一性状拍照器， 所述样本盒支架前侧开设有与样本盒相对设 置的性状拍照口， 所述性状拍照器通过性状拍照口拍摄样本盒内的粪便标本。
进一步地， 所述吸样加样单元包括位于物理检测单元处且可上下移动的第一 机械手、 以及位于化学检测检测单元处且可上下、左右、前后移动的第二机械手， 所述第一机械手上设有第一吸样针， 该第一吸样针与第一蠕动泵相连接， 所述物 理检测单元包括一串联在第一吸样针和第一蠕动泵之间的计数池； 所述第二机械 手上设有第二吸样针， 该第二吸样针和第二蠕动泵相连接， 所述试剂条上设有加 样区和与加样区相对设置的凸起部， 化学检测时， 所述第二加样针穿透凸起部。
优选地， 所述试剂条为塑封试剂条， 包括托板、 盖板和试纸条， 所述托板和 盖板均由塑封膜构成， 且托板和盖板的边缘塑封在一起， 所述试纸条密封在托板 和盖板之间。
进一步地， 所述第一蠕动泵和第二蠕动泵均与清洗液桶相连接， 该清洗液桶 内装有清洗液； 所述第一机械手上设有第一清洗针， 该第一清洗针通过第一清洗 泵与清洗液桶相连接， 所述第一清洗针的端部延伸至第一吸样针的外壁； 所述第 二机械手上设有第二清洗针， 该第二清洗针通过第二清洗泵与清洗液桶相连接， 所述第二清洗针的端部延伸至第二吸样针的外壁。
进一步地， 所述稀释搅拌单元包括可上下移动的第三机械手， 该第三机械手 上设有搅拌电机和加液针， 所述样本盒内设有可转动的采样勺， 当第三机械手下 降时， 所述搅拌电机的输出轴与采样勺同轴连接， 所述加液针插入样本盒内。
优选地， 所述加液针通过第三蠕动泵与一稀释液桶相连接， 所述稀释液桶内 装有稀释液。
优选地，所述化学检测单元有 5〜7个，且每个化学检测单元中的试剂条检测 项目各不相同， 多个化学检测单元左右并排分布。
进一步地， 还包括一位于试剂条上方的光电定位开关， 所述主动滚筒与一步 进电机相连接， 所述光电定位开关、 步进电机均与自动控制器相连接。
如上所述， 本发明涉及的全自动粪便分析仪， 具有以下有益效果： 该全自动粪便分析仪能够自动对多个粪便标本进行连续的物理检测和化学检 测， 其检测效率非常高， 另外， 通过采用试剂条完成对粪便标本的化学检测， 故 检测成本较低， 适合推广应用。 附图说明
图 1为本发明的结构示意图 （该图为俯视图） 。
图 2为图 1中样本盒支架与样本盒的结构示意图。
图 3为图 2的后视图。
图 4为图 2的前视图。
图 5为图 1的 A-A向剖视图。
图 6为图 1的 B-B向剖视图。
图 7为图 1的 C-C向剖视图。
图 8为物理检测单元的管道连接图。
图 9为化学检测单元的管道连接图。
图 10为本发明中试剂条的结构示意图。
图 11为本发明中试剂条卷的结构示意图。 元件标号说明
1 样本盒 2 样本盒支架
21 容腔
22 弹性夹持件
23 条形码扫描口
24 性状拍照口
3 稀释搅拌单元
31 第三机械手
32 搅拌电机
33 加液针
4 化学检测单元
41 主动滚筒
42 从动滚筒
43 试剂条卷
44 试剂条
441 加样区
442 凸起部
443 托板
444 盖板
445 试纸条
446 检测区
5 条形码扫描器
6 性状拍照器
7 吸样加样单元
71 第一机械手
72 第二机械手
73 第一吸样针
74 第一蠕动泵
75 第二吸样针
76 第二蠕动泵 77 清洗液桶
78 第一清洗针
79 第一清洗泵
710 第二清洗针
711 第二清洗泵
8 计数池
9 光电定位开关
10 限位开关 具体实施方式
以下由特定的具体实施例说明本发明的实施方式， 熟悉此技术的人士可由本 说明书所揭露的内容轻易地了解本发明的其他优点及功效。
须知， 本说明书所附图式所绘示的结构、 比例、 大小等， 均仅用以配合说明 书所揭示的内容， 以供熟悉此技术的人士了解与阅读， 并非用以限定本发明可实 施的限定条件， 故不具技术上的实质意义， 任何结构的修饰、 比例关系的改变或 大小的调整， 在不影响本发明所能产生的功效及所能达成的目的下， 均应仍落在 本发明所揭示的技术内容得能涵盖的范围内。 同时，本说明书中所引用的如"上"、 "下"、 "左"、 "右"、 "中间 "及"一"等的用语， 亦仅为便于叙述的明了， 而非用以限 定本发明可实施的范围， 其相对关系的改变或调整， 在无实质变更技术内容下， 当亦视为本发明可实施的范畴。
如图 1所示， 本发明提供一种全自动粪便分析仪， 包括以下部分： 自动控制器；
至少一个样本盒 1， 用于盛放粪便标本；
样本盒支架 2， 用于放置样本盒 1 ;
稀释搅拌单元 3， 用于对样本盒 1 内的粪便标本加稀释液并搅拌， 得到粪便 标本液；
物理检测单元， 用于对粪便标本液进行物理检测；
至少一个化学检测单元 4， 用于对粪便标本液进行化学检测， 每个化学单元 包括主动滚筒 41和从动滚筒 42， 如图 5所示， 所述从动滚筒 42上缠绕有试剂条 卷 43， 该试剂条卷 43的端部固定在主动滚筒 41上， 所述试剂条卷 43包括多个 并排分布、 且依次相连的试剂条 44， 优选地， 一卷试剂条卷 43中有至少 200个 以上的试剂条 44， 较优的为 200人份或 500人份或 800人份；
吸样加样单元 7， 用于吸取粪便标本液， 并将粪便标本液送入所述物理检测 单元和化学检测单元 4。
该全自动粪便分析仪中， 通过样本盒 1采集并盛放粪便标本， 再通过样本盒 支架 2将样本盒 1送入分析仪中稀释搅拌， 后续通过吸样加样单元 7将粪便标本 液输送至物理检测单元处进行物理检测、 以及输送至化学检测单元 4处进行化学 检测， 在化学检测单元 4处， 多个试剂条 44依次相连， 从而可对多个粪便标本进 行连续检测， 大大提高检测效率。 另外， 采用试剂条 44来进行粪便的化学检测， 进一步降低检测成本。 优选地， 还包括与样本盒支架 2相连接的推入机械手、 传 送机械手和推出机械手， 所述推入机械手、 传送机械手、 推出机械手均为步进式 驱动， 也就是采用三套步进电机直线进给机构来拨动样本盒支架 2; 其中， 推入 机械手用于将样本盒支架 2推入分析仪中， 传送机械手用于将样本盒支架 2依次 传送至稀释搅拌单元 3处和物理检测单元处； 待所有的检测完成后， 所述推出机 械手将样本盒支架 2移出分析仪。
优选地，所述化学检测单元 4有 5〜7个，且每个化学检测单元 4中的试剂条 44检测项目各不相同， 多个化学检测单元 4左右并排分布， 多个化学检测单元 4 用于对粪便标本同时进行不同的化学检测， 如可选用 Fob、 轮状病毒、 幽门螺旋 杆菌三个品种的试剂条卷 43， 则在化学检测时， 吸样加样单元 7将吸取的粪便标 本液分别滴入三个品种的试剂条 44上， 即可同时对粪便标本液进行 Fob、轮状病 毒、 幽门螺旋杆菌三个项目的检测。 另外， 本实施例中， 还包括两个备用的化学 检测单元 4， 这两个化学检测单元 4并未安装试剂条卷 43， 为空余试剂位； 当检 测人员上班开机后， 若发现 Fob试剂条仅余 80人份（即 80个）， 而需要进行 Fob 检测的粪便标本有 300个，则可在两个备用的化学检测单元 4中任选一个安装 Fob 试剂条卷， 即可完成对所有粪便标本的 Fob检测； 若检测人员开机后， 分析仪中 的 Fob试剂条有 500人份， 即可马上进行检测， 而不需要使用备用的化学检测单 元 4， 且检测过程中无需停机换试剂或换标本。
优选地， 见图 2， 所述样本盒支架 2上开设有多个开口朝上、 且用于放置样 本盒 1的容腔 21， 该容腔 21与样本盒 1相适配， 所述容腔 21的内壁上设有弹性 夹持件 22，所述样本盒 1放入容腔 21中后，样本盒 1与弹性夹持件 22为面接触、 且为过盈配合， 从而将样本盒 1固定在容腔 21中， 以防止样本盒 1发生移动、窜 动、便宜等现象； 同时， 样本盒 1外壁与弹性夹持件 22的内壁为面接触， 从而增 加两者之间的接触面积， 以保证样本盒 1的定心效果， 进而确保对样本盒 1中的 标本加样、 搅拌、 吸样的顺利进行。 另外， 本实施例中， 所述弹性夹持件 22有两 个， 分别位于容腔 21的上端和下端， 且弹性夹持件 22选用高弹性模量的材料， 如芳纶纤维、 聚乙烯纤维、 高模量玻璃纤维、 高模量碳纤维等， 以增加弹性夹持 件 22的耐磨强度， 延长弹性夹持件 22的使用寿命， 进而延长整个样本盒支架 2 的使用寿命。
进一步地， 还包括一条形码扫描器 5， 所述样本盒 1的后侧贴有条形码， 所 述样本盒支架 2后侧开设有与样本盒 1相对设置的条形码扫描口 23，见图 2和图 3， 所述条形码扫描口 23与容腔 21相连通， 且向上贯穿样本盒支架 2， 所述条形 码扫描器 5通过条形码扫描口 23扫描样本盒 1上的条形码。优选地，还包括一性 状拍照器 6，所述样本盒支架 2前侧开设有与样本盒 1相对设置的性状拍照口 24， 见图 2和图 4， 该性状拍照口 24与容腔 21相连通， 所述性状拍照器 6通过性状 拍照口 24拍摄样本盒 1内的粪便标本， 以观察粪便标本的形状和颜色。所述条形 码扫描器 5和性状拍照器 6沿样本盒支架 2的移动方向前后分布， 故传送机械手 在传送样本盒支架 2时， 位于该样本盒支架 2内的样本盒 1先通过条形码扫描器 5， 以读取病人信息， 并将后续的检测结果都储存在该条形码的信息目录下； 之后 再依次通过性状拍照器 6、 稀释搅拌单元 3和物理检测单元。
进一步地， 如图 6所示， 所述稀释搅拌单元 3包括可上下移动的第三机械手 31， 该第三机械手 31上设有搅拌电机 32和加液针 33， 所述样本盒 1内设有可转 动的采样勺， 当第三机械手 31下降时， 所述搅拌电机 32的输出轴与采样勺同轴 连接， 所述加液针 33插入样本盒 1内。 优选地， 所述加液针 33通过第三蠕动泵 与一稀释液桶相连接， 所述稀释液桶内装有稀释液。 另外， 所述样本盒 1的结构 可参见中国实用新型专利 CN202735110U;所述样本盒 1与搅拌电机 32的连接结 构可参见中国发明专利 CN101487845B。 传送机械手将样本盒支架 2传送至稀释 搅拌单元 3处，且样本盒支架 2上的样本盒 1位于加液针 33的下方；第三机械手 31下移， 则搅拌电机 32的输入轴与采样勺同轴连接， 且加液针 33插入样本盒 1 中； 第三蠕动泵转动， 则稀释液通过加液针 33进入样本盒 1中； 搅拌电机 32转 动， 带动采样勺转动， 进而完成对粪便标本的定量加液稀释和合理搅拌。 进一步地， 见图 7， 所述吸样加样单元 7包括位于物理检测单元处且可上下 移动的第一机械手 71、 以及位于化学检测检测单元处且可上下、 左右、 前后移动 的第二机械手 72， 所述第一机械手 71上设有第一吸样针 73， 该第一吸样针 73 与第一蠕动泵 74相连接，见图 8，所述物理检测单元包括一串联在第一吸样针 73 和第一蠕动泵 74之间的计数池 8; 所述第二机械手 72上设有第二吸样针 75， 该 第二吸样针 75和第二蠕动泵 76相连接，见图 9，所述试剂条 44上设有加样区 441 和与加样区 441相对设置的凸起部 442， 见图 10， 化学检测时， 所述第二加样针 穿透凸起部 442。 所述第二机械手 72 即为一三维机械手， 可在 X 方向上移动 800mm, 在 Y方向上移动 300mm， 在 Z方向上移动 100mm。
另外， 为了进一步降低检测成本， 本发明从降低试剂条 44的成本出发， 将试 剂条 44设计为塑封试剂条 44， 见图 10和图 11， 该塑封试剂条 44包括托板 443、 盖板 444和试纸条 445， 所述托板 443和盖板 444均由塑封膜构成， 且托板 443 和盖板 444的边缘塑封在一起，所述试纸条 445密封在托板 443和盖板 444之间， 所述试纸条 445上还设有检测区 446。 所述托板 443和盖板 444均是由塑封膜构 成， 有效降低试剂条 44的制造成本， 提高经济效益。 同时， 托板 443和盖板 444 的边缘塑封在一起， 将试纸条 445密封在托板 443和盖板 444之间， 有效保障试 剂条 44的干燥性，进而使试剂条 44能长时间暴露在空气中而不会发潮。优选地， 相邻的两个塑封试剂条 44通过撕裂线相连接， 可便于将单个的塑封试剂条 44撕 下， 单独使用， 以满足不同场合的需求。
物理检测时，盛放有粪便标本液的样本盒 1位于第一吸样针 73的下方，第一 机械手 71下移， 则第一吸样针 73插入样本盒 1中， 第一蠕动泵 74正转， 则粪便 标本液从样本盒 1中吸出并通过第一吸样针 73进入计数池 8中，以进行镜下检测； 镜检模块具有预调对焦功能，且计数池 8能作水平方向的多点移位。化学检测时， 第二机械手 72移动， 使第二吸样针 75插入样本盒 1中， 第二蠕动泵 76正转， 则 粪便标本液从样本盒 1中吸入第二吸样针 75中； 第二机械手 72再移动， 使第二 吸样针 75插入试剂条 44上的凸起部 442内，第二蠕动泵 76反转，则第二吸样针 75内的粪便标本液滴在该试剂条 44的加样区 441上， 从而进行化学检测。 本实 施例中，所述第二机械手 72上设有一拍照相机，对反应后的试剂条 44进行拍照， 自动控制器再控制一判读软件对所获取的照片进行判读， 作出定性结论， 进而得 出化学检测结果， 从而防止因人工判读而引起的误差， 提高检测精度和速度， 实 现全自动检测。 优选地， 所述物理检测单元处设有一光电传感器， 用于对样本盒 1位置的确认。
对一个粪便标本液检测完成后， 必须清洗第一吸样针 73和第二吸样针 75的 内壁、 外壁， 方可对下个粪便标本液检测。 本实施例中， 清洗结构为： 见图 8和 图 9， 所述第一蠕动泵 74和第二蠕动泵 76均与清洗液桶 77相连接， 该清洗液桶 77 内装有清洗液； 所述第一机械手 71上设有第一清洗针 78， 该第一清洗针 78 通过第一清洗泵 79与清洗液桶 77相连接，所述第一清洗针 78的端部延伸至第一 吸样针 73的外壁；所述第二机械手 72上设有第二清洗针 710，该第二清洗针 710 通过第二清洗泵 711与清洗液桶 77相连接，所述第二清洗针 710的端部延伸至第 二吸样针 75的外壁。
物理检测完成后， 第一蠕动泵 74反转， 清洗液桶 77内的清洗液被吸入， 并 通过计数池 8进入第一吸样针 73内，进而清洗计数池 8和第一吸样针 73的内壁； 第一清洗泵 79转动，清洗液被第一清洗针 78吸入，并沿第一吸样针 73的外壁流 下， 进而清洗第一吸样针 73的外壁。 化学检测完成后， 第二蠕动泵 76反转， 清 洗液桶 77内的清洗液被吸入第二吸样针 75内， 进而清洗第二吸样针 75的内壁； 第二清洗泵 711转动，清洗液被第二清洗针 710吸入， 并沿第二吸样针 75的外壁 流下，进而清洗第二吸样针 75的外壁。清洗第一吸样针 73和第二吸样针 75后的 废液流入一废液桶内， 便于废液的集中排出， 且该废液桶内设有一液位开关， 用 于上位报警， 即当废液桶内的液面高出该液位开关时， 液位开关被触发， 自控控 制器根据该触发信号发出警报。另外，所述稀释液桶和清洗液桶 77内也设有液位 开关， 用于下位警报， 即当稀释液桶内的稀释液液面低于液位开关或当清洗液桶 77内的清洗液液面低于液位开关时， 液位开关被触发， 自控控制器根据该触发信 号发出警报。
优选地， 在清洗第一吸样针 73和第二吸样针 75时， 自动控制器控制第一蠕 动泵 74、 第二蠕动泵 76、 第一清洗泵 79以及第二清洗泵 711间隙式转动， 从而 使清洗管道内间隔分布有一段清洗液、 一段空气、 一段清洗液、 一段空气…， 清 洗液会被间隙式送出， 且在空气的作用下管道内压力增大， 进而使清洗液以爆破 的方式冲刷第一吸样针 73的内壁和外壁、 以及第二吸样针 75的内壁和外壁， 其 冲刷力度大， 从而保证清洗效果。
进一步地，还包括一位于试剂条 44上方的光电定位开关 9，所述主动滚筒 41 与一步进电机相连接， 所述光电定位开关 9、 步进电机均与自动控制器相连接； 所述步进电机驱动主动滚筒 41步进式滚动，且在光电定位开关 9的作用下，保证 滚筒每转动一次， 试剂条卷 43以一个试剂条 44为单位前进一次。
本发明涉及的全自动粪便分析仪在工作前， 推入机械手停留在仪器最前方， 传送机械手停留在仪器最左边， 第三机械手 31停留在最上方， 第一机械手 71停 留在物理检测单元处的最上方， 第二机械手 72停留在试剂条 44的最上方， 试剂 卡仓停留在初始位或记忆位， 推出机械手停留在仪器后端。 在工作时， 人工将多 个样本盒 1放入样本盒支架 2中， 每个样本盒 1内盛放有不同病人的粪便标本， 如图 1所示， 推入机械手将样本盒支架 2推入分析仪中， 以图 1的视图角度看， 样本盒支架 2是由前向后进入仪器中； 当样本盒支架 2碰到仪器后端的限位开关 10时， 推入机械手停止运动， 传送机械手将样本盒支架 2从右向左步进式横向传 送，并依次经过条形码扫描器 5、性状拍照器 6、稀释搅拌单元 3和物理检测单元; 在连续步进式传送的过程中， 位于物理检测单元处的粪便标本液进行物理检测和 化学检测， 同时， 位于稀释搅拌单元 3处的粪便标本进行稀释和搅拌， 从而使该 仪器对多个不同的粪便标本连续进行检测，检测速度可达每小时 120个粪便标本， 进而大大提高检测效率。 优选地， 仪器还配备电脑和打印机， 所述打印机用于打 印一个粪便标本的检测结果。
综上所述，本发明有效克服了现有技术中的种种缺点而具高度产业利用价值。 上述实施例仅例示性说明本发明的原理及其功效， 而非用于限制本发明。 任 何熟悉此技术的人士皆可在不违背本发明的精神及范畴下， 对上述实施例进行修 饰或改变。 因此， 举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的 精神与技术思想下所完成的一切等效修饰或改变， 仍应由本发明的权利要求所涵

Claims

权利要求书
1、 一种全自动粪便分析仪， 其特征在于： 包括以下部分：
自动控制器；
至少一个样本盒， 用于盛放粪便标本；
样本盒支架， 用于放置样本盒；
稀释搅拌单元， 用于对样本盒内的粪便标本加稀释液并搅拌， 得到粪便标本液； 物理检测单元， 用于对粪便标本液进行物理检测；
至少一个化学检测单元， 用于对粪便标本液进行化学检测， 每个化学单元包括主动滚筒 和从动滚筒， 所述从动滚筒上缠绕有试剂条卷， 该试剂条卷的端部固定在主动滚筒上， 所述 试剂条卷包括多个并排分布、 且依次相连的试剂条；
吸样加样单元， 用于吸取粪便标本液， 并将粪便标本液送入所述物理检测单元和化学检 测单元。
2、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 所述样本盒支架上开设有多个 开口朝上、 且用于放置样本盒的容腔， 所述容腔的内壁上设有弹性夹持件， 所述样本盒 放入容腔中后， 样本盒与弹性夹持件为面接触、 且为过盈配合。
3、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 还包括一条形码扫描器， 所述 样本盒的后侧贴有条形码， 所述样本盒支架后侧开设有与样本盒相对设置的条形码扫描 口， 所述条形码扫描器通过条形码扫描口扫描样本盒上的条形码。
4、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 还包括一性状拍照器， 所述样 本盒支架前侧开设有与样本盒相对设置的性状拍照口， 所述性状拍照器通过性状拍照口 拍摄样本盒内的粪便标本。
5、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 所述吸样加样单元包括位于物 理检测单元处且可上下移动的第一机械手、 以及位于化学检测检测单元处且可上下、 左 右、 前后移动的第二机械手， 所述第一机械手上设有第一吸样针， 该第一吸样针与第一 蠕动泵相连接， 所述物理检测单元包括一串联在第一吸样针和第一蠕动泵之间的计数 池； 所述第二机械手上设有第二吸样针， 该第二吸样针和第二蠕动泵相连接， 所述试剂 条上设有加样区和与加样区相对设置的凸起部， 化学检测时， 所述第二加样针穿透凸起 部。 、 根据权利要求 1 或 5 所述的全自动粪便分析仪， 其特征在于： 所述试剂条为塑封试剂 条， 包括托板、 盖板和试纸条， 所述托板和盖板均由塑封膜构成， 且托板和盖板的边缘 塑封在一起， 所述试纸条密封在托板和盖板之间。 、 根据权利要求 5 所述的全自动粪便分析仪， 其特征在于： 所述第一蠕动泵和第二蠕动泵 均与清洗液桶相连接， 该清洗液桶内装有清洗液； 所述第一机械手上设有第一清洗针， 该第一清洗针通过第一清洗泵与清洗液桶相连接， 所述第一清洗针的端部延伸至第一吸 样针的外壁； 所述第二机械手上设有第二清洗针， 该第二清洗针通过第二清洗泵与清洗 液桶相连接， 所述第二清洗针的端部延伸至第二吸样针的外壁。 、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 所述稀释搅拌单元包括可上下 移动的第三机械手， 该第三机械手上设有搅拌电机和加液针， 所述样本盒内设有可转动 的采样勺， 当第三机械手下降时， 所述搅拌电机的输出轴与采样勺同轴连接， 所述加液 针插入样本盒内。 、 根据权利要求 8 所述的全自动粪便分析仪， 其特征在于： 所述加液针通过第三蠕动泵与 一稀释液桶相连接， 所述稀释液桶内装有稀释液。 、 根据权利要求 1所述的全自动粪便分析仪， 其特征在于： 所述化学检测单元有 5〜7 个， 且每个化学检测单元中的试剂条检测项目各不相同， 多个化学检测单元左右并排分 布。 1、 根据权利要求 1 所述的全自动粪便分析仪， 其特征在于： 还包括一位于试剂条上方 的光电定位开关， 所述主动滚筒与一步进电机相连接， 所述光电定位开关、 步进电机均 与自动控制器相连接。
PCT/CN2014/075231 2013-10-30 2014-04-14 全自动粪便分析仪 WO2015062208A1 (zh)

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CN108132179A (zh) * 2016-03-17 2018-06-08 梁怡芃 一种检验粪便内容物用自动预处理装置
CN117947140A (zh) * 2024-01-24 2024-04-30 陈娟 一种食品检测工艺

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CN107167619A (zh) * 2017-05-18 2017-09-15 易源易贝（北京）科技有限公司 一种流体试样检测系统和检测方法
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CN112595709A (zh) * 2020-10-27 2021-04-02 重庆建工建材物流有限公司 机制砂亚甲蓝试验自动装置及方法
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CN117947140A (zh) * 2024-01-24 2024-04-30 陈娟 一种食品检测工艺

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US20220178956A1 (en) 2022-06-09
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