WO2015055234A1 - Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces - Google Patents

Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces Download PDF

Info

Publication number
WO2015055234A1
WO2015055234A1 PCT/EP2013/071536 EP2013071536W WO2015055234A1 WO 2015055234 A1 WO2015055234 A1 WO 2015055234A1 EP 2013071536 W EP2013071536 W EP 2013071536W WO 2015055234 A1 WO2015055234 A1 WO 2015055234A1
Authority
WO
WIPO (PCT)
Prior art keywords
preferred
composition
alkaline
salts
further preferred
Prior art date
Application number
PCT/EP2013/071536
Other languages
English (en)
Inventor
Carola Stingl
Laurence Geret
Bernhard Meyer
Original Assignee
Ecolab Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecolab Inc. filed Critical Ecolab Inc.
Priority to PCT/EP2013/071536 priority Critical patent/WO2015055234A1/fr
Publication of WO2015055234A1 publication Critical patent/WO2015055234A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707—Polyethers, e.g. polyalkyleneoxides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/02—Inorganic compounds
    • C11D7/04—Water-soluble compounds
    • C11D7/06—Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces
    • C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines

Definitions

  • the invention relates to the use of a concentrated solid alkaline composition for inactivating and/or reducing unconventional infectious agents, such as prions, on surfaces.
  • the invention relates further to the use of a concentrated solid alkaline composition for automated cleaning and disinfection processing of surfaces that can be contaminated with unconventional infectious agents.
  • the invention relates to the use of solid alkaline concentrated compositions useful in the cleaning and/or disinfecting of articles or surfaces that are potentially contaminated with unconventional infectious agents, including plastic articles, plastic surfaces, metal articles, metal surfaces, such as surgical, medical, and dental instruments.
  • the term "destruction of prions” as used herein means an irreversible destruction of infectivity and/or reduction of unconventional infectious agents, such as prions, on a surface to which the disinfectant composition in form of a solution is applied.
  • the term “destruction of prions” as used herein means the irreversible destruction of infectivity and/or reduction of unconventional infectious agents, such as prions, on a surface to which the disinfectant composition in form of a solution is applied according to a standard protocol published by the French medical device authority erson National de Securite du Medicaments et de wall de sante (ANSM).
  • Unconventional infectious agents are agents that are effective to cause degeneration of the central nervous system. Unconventional infectious agents are for example prions.
  • TSEs transmissible spongiform encephalopathies
  • Transmissible spongiform encephalopathies include Creutzfeldt-Jakob disease (CJD) in humans, Bovine Spongiform Encephalopathy (BSE) in cattle, Scrapie in sheep, and Wasting Disease in elk. These diseases attack the neurological organs, the brain and nervous system.
  • Prions cannot be transmitted through the air or through touching or most other forms of casual contact.
  • prion diseases can be transmitted through contact with infected tissue, body fluids, for example brain tissue, cerebral spinal fluids, and eye tissue and fluids or contaminated medical instruments.
  • Surgical, medical, and dental instruments after use are typically contaminated with blood and other body matter and potentially with infectious agents.
  • surgical instrument particularly neurosurgical and ophthalmological instruments are washed and disinfected as indicated.
  • prions are resistant to routine physical and chemical disinfection and sterilization measures and normal sterilization procedures such as liquid sterilization systems, boiling or irradiating materials fail to render prions non-infective. Unlike microorganisms, prions appear not to have any recognizable nucleic acid component, and therefore may be resistant to conventional inactivation techniques for infectious agents.
  • Sodium hydroxide concentrated compositions and high concentration of hypochlorite causes chemical "burns" if splashed onto the skin and causes corrosion of sensitive metal surfaces that come into contact therewith.
  • alkali cleaners know in prior art comprising tensides show when used, for example in automated cleaning processing, increased foam formation.
  • foam lowers the cleaning properties, due to the reduced contact area as well as due to the loss of mechanical agitation. Further, pumping of foam dramatically reduces the liquid flow rates, thus causes dosing and transport problems in the sump, liquid conduits, as well as in the dispensing drawer. Thus, foam in general is not acceptable for cleaning and disinfection processing, including automated processing, of surfaces that can be contaminated with unconventional infectious agents.
  • alkali cleaners has disadvantages when used on alkaline sensitive metals, such as, aluminum.
  • a problem with using aqueous alkali systems to clean aluminum surfaces is the potential to corrode and/or discolor.
  • the object underlying the present invention is to provide a composition that can be used effective against unconventional infectious agents, such as prions and has a good cleaning performance, low foaming, and are fewer surface destructive, especially for metal surfaces.
  • the object underlying the present invention is to provide a use of a composition that is effective to irreversible destroy and/or to reduce unconventional infectious agents, such as prions and has a good cleaning performance, low foaming, and are fewer surface destructive, especially for metal and/or plastic surfaces.
  • Another aspect is the use of a solid alkaline composition for cleaning processing of surfaces, such as hard and/or soft surfaces, effective to inactivate and/or to reduce unconventional infectious agents, such as prions and has a good cleaning performance, low foaming, and are fewer surface destructive, especially for metal surfaces.
  • Another aspect is the use of a solid alkaline composition for automated cleaning processing of surfaces, such as hard surfaces and/or soft surfaces, for example metal and/or plastic surfaces, effective to inactivate and/or to reduce unconventional infectious agents, such as prions and has a good cleaning performance, low foaming, and are fewer surface destructive, especially for metal surfaces.
  • a solid alkaline composition comprising at least one alkaline source, at least one polyethylene glycol and at least one corrosion inhibitor, wherein the ratio of alkaline source to polyethylene glycol is in the range from about 30 : 1 to about 2 : 1.
  • a solid alkaline composition comprising at least one alkaline source, at least one polyethylene glycol and at least one corrosion inhibitor, wherein the ratio of alkaline source to polyethylene glycol is in the range from about 30 : 1 to about 2 : 1.
  • the solid alkaline composition can be used for cleaning and/or destruction of prions of surfaces contaminated with unconventional infectious agents, comprising at least one alkaline source and at least one polyethylene glycol, wherein the ratio of alkaline source to polyethylene glycol is in the range from about 30 : 1 to about 2 : 1, wherein the composition comprises at least one corrosion inhibitor.
  • the composition may comprises at least one corrosion inhibitor in an amount of > 2 wt.-% to about ⁇ 10 wt.-%, preferably about > 3 wt.-% to about ⁇ 9 wt.-%, further preferred about > 4 wt.-% to about ⁇ 8 wt.-%, and more preferred about > 5 wt.-% to about ⁇ 6 wt.-%, wherein the weight-% of the corrosion inhibitor are based on the total weight of the solid composition and more preferred the corrosion inhibitor is free of a silicate.
  • the unconventional infectious agents comprising agents that are effective to cause degeneration of the central nervous system, preferably the unconventional infectious agents are prions.
  • a solid alkaline composition comprising at least one alkaline source, at least one polyethylene glycol and at least one corrosion inhibitor, wherein the ratio of alkaline source to polyethylene glycol is in the range from about 30 : 1 to about 2 : 1 is effective to irreversibly destroy and/or to reduce unconventional infectious agents, such as prions on surfaces, contaminated therewith.
  • a low alkaline ready-to-use solution is effective to irreversibly destroy and/or to reduce unconventional infectious agents, such as prions on surfaces, contaminated therewith.
  • the solid concentrated alkaline composition can be used for automated cleaning processing of metal surface layers to remove blood or other matter are allowed to dry and irreversibly destroys and/or reduces unconventional infectious agents, such as prions.
  • the solid concentrated alkaline composition shows a rapid dissolution in water, and develops after dissolution based on a low active concentration a good cleaning effect and irreversibly destroys and/or reduces unconventional infectious agents, such as prions.
  • the solid alkaline composition can be used according to the invention for automated cleaning processing of surfaces, such as hard and/or soft surfaces, for example metal and/or plastic surfaces to effectively irreversibly destroy and/or to reduce unconventional infectious agents, such as prions contaminated therewith. Further, using the alkaline composition shows practical no foam formation during the automated processing and prevents corrosion of metal surfaces that are exposed to aqueous alkaline solutions. Thus, using the alkaline cleaning composition is remarkable sensitive to metal articles, metal surfaces, plastic articles and/or plastic surfaces.
  • the alkaline composition can be used to inactivate and/or to reduce unconventional infectious agents on surfaces in hospitals, industrial facilities and research
  • laboratories particularly selected from surfaces of instruments employed in medical, dental, and pharmaceutical procedures, surfaces of equipment, processing facilities or containers used in the food service, food processing, butchery, dairy, beverage, brewery, and pharmaceutical industries, work surfaces, walls, floors, ceilings, fermentation tanks, and fluid supply lines.
  • alkaline sensitive metal identifies those metals that exhibit corrosion and/or discoloration when exposed to an aqueous alkaline solution.
  • An aqueous alkaline solution is an aqueous solution having a pH that is greater than about 8.
  • Exemplary alkaline sensitive metals include soft metals such as aluminum, nickel, tin, zinc,/copper, brass, bronze, and mixtures thereof.
  • Aluminum and aluminum alloys are common alkaline sensitive metals that can be cleaned by the cleaning compositions of the invention.
  • references herein to a "solid" composition are to those, which are solid at about 15° C and up to about 60° C.
  • the shape of the solid composition of the present invention is preferably stable and/or the solid composition is rigid.
  • a solvent preferably water
  • the solvent content, such as the water content, of the composition for use according to the invention is simply determined by subtracting the amounts of all the usual ingredients from 100 wt. %.
  • the weight-% (wt.-%) of the components are calculated based on the total weight amount of the composition, if not otherwise stated.
  • the ratio of components is parts by weight, if not otherwise stated.
  • the total amount of all components of the composition does not exceed 100 wt.-%.
  • compositions for use according to the invention are free of other surfactants, except polyethylene glycol.
  • compositions for use according to the invention can be free of a hydrotrope component.
  • compositions for use according to the invention can be free of a zeolite.
  • compositions for use according to the invention can be free of at least one additive, preferably all additives, selected from the group of antimicrobials, fungicides, fragrances, dyes, antistatic agents, UV absorbers, reducing agents and/or buffering compounds.
  • the specific ratio of the alkaline source to polyethylene glycol according to the present invention provides a good cleaning effect in combination with low foaming as required for an automated processing of metal articles, metal surfaces, plastic articles and/or plastic surfaces.
  • the ratio or concentration of polyethylene glycol in the solid alkaline composition for use according to the invention is selected to high. However, if the ratio or concentration of polyethylene glycol is selected to low, the cleaning action is insufficient.
  • the ratio of alkaline source to polyethylene glycol can be in the range from about 30 : 1 to about 2 : 1, preferably about 25 : 1 to about 5 : 1, further preferred about 22 : 1 to about 8 : 1, also preferred about 20 : 1 to about 10 : 1 and in addition preferred about 18.5 : 1 to about 16 : 1.
  • the cleaning and destruction of prions action of a solid alkaline composition for use according to the invention used in an automated washing process is surprisingly good, although the concentration of the polyethylene glycol in the solid alkaline composition for use according to the invention is relatively low.
  • body fluids such as blood, lipids and synovial fluids from joints adhere to the items metal surface used during a procedure. As these fluids dry, the adhesion gets stronger and the fluids get harder to dissolve using ordinary cleaning methods. Blood in particular becomes much more difficult to remove once it has dried. Eventually, the adhesion of the soils becomes too strong for normal detergents to break and the instruments remain soiled after cleaning.
  • a problem with using aqueous alkali systems to clean metal surfaces, such as aluminum surfaces is the potential to corrode and/or discolor. Therefore, a corrosion inhibitor is used to prevent corrosion of metal surfaces that are exposed to aqueous alkaline solutions.
  • silicate(s) corrosion inhibitor is optional and can be omitted.
  • Silicates comprising sodium silicate, have a tendency to begin precipitating from aqueous solution at a pH below 11 , thus reducing its effectiveness to prevent corrosion of the contacted surfaces when used in aqueous cleaning solutions having a lower pH.
  • silicates when silicates are allowed to dry on the surface to be cleaned, films or spots are often formed, which are visible and they are very difficult to remove.
  • the presence of these silicon-containing deposits can affect the texture of the cleaned surface, the appearance of the surface, and on cooking or storage surfaces, can affect the taste of the materials that come into contact with the cleaned surfaces.
  • the alkaline composition for use according to the invention it is found to be a sensitive metal and/or plastic cleaning composition.
  • the sensitive metal and/or plastic cleaning composition for use according to the invention in use minors or avoids corrosion in such an extent that the addition of silicate(s) corrosion inhibitor is not required.
  • a solid composition comprising a silicate(s) corrosion inhibitor
  • the silicate(s) corrosion inhibitor can be an alkali silicate, particularly preferably crystalline or amorphous alkali disilicates in quantities of about > 0.05 to about ⁇ 10, preferably about > 0.1 to about ⁇ 5 and more preferred of about > 0.5 to about ⁇ 2; wherein the weight- % of the components are based on the total weight of the composition.
  • an aqueous alkaline composition having a high pH are often more corrosive than an aqueous composition having a light acidic pH.
  • the pH of the aqueous alkaline solutions of the solid alkaline composition can be adjusted to a lower pH in the range of about > 11 pH to about ⁇ 13.5 pH.
  • an aqueous solution of the solid alkaline composition can be improved by adding at least one sequestering agent to the solid alkaline composition, preferably at least one sequestering agent that exhibits soil removal properties.
  • the source of alkalinity can be any source of alkalinity that is compatible with the other components of the concentrated solid alkaline composition and that will provide the use of a solution, i.e. concentrated liquid composition as well as the ready-to-use solution with the desired pH and is effective to inactivate and/or to reduce unconventional infectious agents, such as prions, on surfaces that are potentially contaminated therewith.
  • exemplary sources of alkalinity include alkali metal hydroxides, alkali metal salts, phosphates, amines, and mixtures thereof.
  • Exemplary alkali metal hydroxides include sodium hydroxide, potassium hydroxide, and lithium hydroxide.
  • Exemplary alkali metal salts include sodium carbonate, trisodium phosphate, potassium carbonate, and mixtures thereof.
  • Exemplary phosphates include sodium pyrophosphate, potassium pyrophosphate, and mixtures thereof.
  • Exemplary amines include alkanolamine selected from the group comprising triethanolamine, monoethanolamine, diethanolamine, and mixtures thereof.
  • the source of alkalinity preferably an alkali metal hydroxide
  • Alkali metal hydroxides are commercially available as pellets or beads having a mix of particle sizes ranging from 12-100 U. S. mesh, or as an aqueous solution, as for example, as about 45 wt. %, about 50 wt. % and about 73 wt. % solution.
  • the source of alkalinity preferably an alkali metal hydroxide, and more preferred sodium hydroxide, can be used in quantities of about > 10 wt.-% to about ⁇ 50 wt.-%, preferably about > 15 wt- % to about ⁇ 45 wt.-%, further preferred about > 20 wt- % to about ⁇ 40 wt- %, also preferred about > 30 wt-% to about ⁇ 38 wt.-%and more preferred about > 35 wt-% to about ⁇ 37 wt-%;
  • weight- % of the components are based on the total weight of the composition.
  • a suitable polyethylene glycol for use in the present invention can have a molecular weight (MW) in the range of about > 4000 to about ⁇ 12000, preferably about > 6000 to about ⁇ 10000 and more preferred of about > 7000 to about ⁇ 8000.
  • Polyethylene glycol that can be used are marketed for example by BASF under the tradename PLURIOL ® .
  • the source of polyethylene glycol preferably a polyethylene glycol with a MW in the range of 4.000 to 12.000, can be used in quantities of about > 0.1 wt-% to about ⁇ 15 wt-%, preferably about > 0.5 wt.-%> to about ⁇ 10 wt.-%>, further preferred about > 1 wt.-%> to about ⁇ 5 wt.-%>, and more preferred about > 2 wt.-% to about ⁇ 3 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • the corrosion inhibitor can be selected from the group comprising silicate, calcium acetate, calcium chloride, calcium gluconate, calcium phosphate, calcium borate, calcium carbonate, calcium citrate, calcium lactate, calcium sulfate, calcium tartrate, benzotriazole, 1,2,3-benzotriazole and mixtures thereof.
  • the corrosion inhibitor is a heterocyclic compound, a triazole derivate, such as a benzotriazole or 1,2,3-benzotriazole and mixtures thereof.
  • silicates include sodium metasilicates, sesquisilicates, orthosilicates, potassium silicates, and mixtures thereof. However, most preferred can be sodium silicate.
  • the silicates may comprise at least one crystalline layer-forming silicate of the general formula NaMSix02x+l .yH20, wherein M represents sodium or hydrogen, x is a number from about 1.9 to about 22, preferably about 1.9 to about 4 and y stands for a number from about 0 to about 33.
  • the crystalline layer-forming silicates of the formula NaMSix022x+l .yH20 are marketed for example by Clariant GmbH (Germany) under the trade names Na-SKS, eg.
  • Na-SKS-1 Na2Si22045.xH20, Kenyait
  • Na-SKS-2 Na2Sil4029.xH20, Magadiit
  • Na-SKS-3 Na2Si8017.xH20
  • Na-SKS-4 Na2Si409.xH20, Makatit
  • Crystalline, layered silicates of the above formula, in which x stands for 2, are particularly suitable for the purposes for use according to the invention.
  • Na-SKS-5 alpha -Na2Si205
  • Na-SKS-7 beta -Na2Si205, Natrosilit
  • Na-SKS-9 alpha -Na2Si205
  • Na-SKS-10 NaHSi205.3H20, Kanemit
  • Na-SKS-11 t-Na2Si205
  • Na-SKS- 13 NaHSi205
  • Na-SKS-6 delta -Na2Si205
  • silicates can comprise a content by weight of crystalline layered silicates of formula NaMSix02x+l.yH20 of 0.1 to 20 wt. %, preferably about 0.2 to about 15 wt. % and particularly about 0.4 to about 10 wt. %, each based on the total weight of the corrosion inhibitor agent.
  • a silicate(s) corrosion inhibitor is optional and can be omitted.
  • other corrosion inhibitors can be suitable added to the solid alkaline composition of this invention include magnesium and/or zinc ions and Ca (N0 2 ) 2 ⁇
  • the metal ions are provided in water-soluble form.
  • Examples of useful water-soluble forms of magnesium and zinc ions are the water-soluble salts thereof including the chlorides, nitrates and sulfates of the respective metals. If any of the alkalinity providing agents are the alkali metal carbonates, bicarbonates or mixtures of such agents, magnesium oxide can be used to provide the Mg ion.
  • the magnesium oxide is water soluble and is a preferred source of Mg ions.
  • the useful carboxylated polymer corrosion inhibitors may be generically categorized as water- soluble carboxylic acid polymers such as polyacrylic and polymethacrylic acids or vinyl addition polymers, in addition to the acid-substituted polymers used in the present invention.
  • maleic anhydride copolymers as with vinyl acetate, styrene, ethylene, isobutylene, acrylic acid and vinyl ethers are examples.
  • the polymers tend to be water-soluble or at least colloidally dispersible in water.
  • the molecular weight of these polymers may vary over a broad range although it is preferred to use polymers having average molecular weights ranging between about 1,000 up to about 1,000, 000. These polymers have a molecular weight of about 100,000 or less and between about 1,000 and about 10,000.
  • the polymers or copolymers may be prepared by either addition or hydrolytic techniques.
  • maleic anhydride copolymers are prepared by the addition polymerization of maleic anhydride and another comonomer such as styrene.
  • the low molecular weight acrylic acid polymer corrosion inhibitors may be prepared by addition polymerization of acrylic acid or its salts either with itself or other vinyl comonomers.
  • such polymers may be prepared by the alkaline hydrolysis of low molecular weight acrylonitrile homopolymers or copolymers.
  • the corrosion inhibitor can be used in quantities of about > 2 wt.-% to about ⁇ 10 wt.-%, preferably about > 3 wt.-% to about ⁇ 9 wt.-%, further preferred about > 4 wt.-% to about ⁇ 8 wt.-%, and more preferred about > 5 wt.-% to about ⁇ 6 wt.-%; wherein the weight- % of the components are based on the total weight of the composition.
  • the solid alkaline composition that can be used according to the present invention can comprise at least one threshold inhibitor/crystal modifier.
  • the amount of threshold inhibitor/crystal modifier can be about > 1 wt.-% to about ⁇ 15 wt.-%, preferably about > 3 wt.-% to about ⁇ 12 wt.-%, further preferred about > 5 wt.-% to about ⁇ 16 wt.-%, and more preferred about > 6 wt.-% to about ⁇ 8 wt.-%, wherein the weight-% of the components are based on the total weight of the composition.
  • the threshold inhibitor/crystal modifier can be selected from the group comprising salts of phosphonocarboxylic acids, phosphonates, salts of 1 -hydroxy ethylidene -1,1,-diphosphonic acid (HEDP), salts of acid substituted polymers, and mixtures thereof, preferably salts of acid substituted polymers of monomers of acrylate, methacrylate, salts of polyitaconic acid, salts of polymaleic acid, and mixtures thereof. In particular preferred are salts of polyacrylic acid.
  • the solid alkaline composition that can be used according to the present invention can comprise at least one sequestering agent.
  • the amount of sequestering agent can be about > 5 wt.-% to about ⁇ 40 wt.-%, preferably about > 10 wt.-% to about ⁇ 35 wt.-%, further preferred about > 20 wt- % to about ⁇ 30 wt.-%, and more preferred about > 25 wt.-% to about ⁇ 28 wt.-%, wherein the weight- % of the components are based on the total weight of the composition.
  • the sequestering agent can be selected from the group of sodium gluconate, pentasodium salt of diethylenetriamine pentaacetic acid, sodium glucoheptonate, salts of ethylene diamine tetraacetic acid, salts of ethylene diamine tetraacetic acid, salts of hydroxyethyl ethylene diamine triacetic acid, salts of hydroxyethyl ethylene diamine triacetic acid, salts of nitrilotriacetic acid, salts of
  • nitrilotriacetic acid diethanolglycine sodium salt
  • ethanoldiglycine disodium salt salts of
  • hydroxymonocarboxylic acid compounds salts of hydroxydicarboxylic acid compounds, salts of amine containing carboxylic acids, terasodium N,N-bis(carboxylatomethyl)-L-glutamate (GDLA) and mixtures thereof.
  • GDLA terasodium N,N-bis(carboxylatomethyl)-L-glutamate
  • At least one sequestering agent that exhibits soil removal properties when used at a pH of at least about 10.0.
  • the sequestering agent is provided for tying up metals in the soil to assist in cleaning and detergency.
  • the sequestering agent can be provided as part of the solid alkaline composition.
  • Exemplary sequestering agents that exhibit soil removal properties at a pH of greater than about 10.0 that can be used according to the invention include sodium gluconate, pentasodium salt of diethylenetriamine pentaacetic acid (available under the name Versenex 80), sodium glucoheptonate, ethylene diamine tetraacetic acid (EDTA), salts of ethylene diamine tetraacetic acid, hydroxyethyl ethylene diamine triacetic acid (HEDTA), salts of hydroxyethyl ethylene diamine triacetic acid, nitrilotriacetic acid (NTA), salts of nitrilotriacetic acid, diethanolglycine sodium salt (DEG), ethanoldiglycine disodium salt (EDG), tetrasodium N,N-bis(carboxylatomethyl)-L- glutamate (GLDA), methyl glycine diacetic acid (MGDA)and mixtures thereof.
  • EDTA ethylene diamine tetra
  • Exemplary salts of ethylene diamine tetraacetic acid include disodium salts, tetrasodium salts, diammonium salts, and trisodium salts.
  • An exemplary salt of hydroxy ethyl ethylene diamine triacetic acid is the trisodium salt.
  • the sequestering agent can include mixtures of different sequestering agents.
  • Suitable solvents include, but are not limited to, water, alcohols, glycols, glycol ethers, esters, and the like, or combinations thereof.
  • Suitable alcohols include, but are not limited to, ethanol, isopropanol (propan-2-ol), 2-butoxy ethanol (butyl glycol), 1-decanol, benzyl alcohol, glycerin, monoethanolamine (MEA), and the like, or combinations thereof.
  • a solid alkaline composition that can be used according to the invention and is effective to inactivate and/or to reduce unconventional infectious agents, such as prions, on surfaces that are potentially contaminated therewith comprises:
  • a solid alkaline composition comprising: - about > 10 wt.-% to about ⁇ 50 wt.-%, preferably about > 15 wt.-% to about ⁇ 45 wt.-%, further preferred about > 20 wt.-% to about ⁇ 40 wt.-%, also preferred about > 30 wt.-% to about ⁇ 38 wt.-%, and more preferred about > 35 wt.-% to about ⁇ 37 wt.-%, of at least one alkaline metal hydroxide, preferably sodium hydroxide;
  • the threshold inhibitor/crystal modifier is a salt of a polyacrylic acid
  • the sequestering agent is a salt of an amine containing carboxylic acid; a solvent, preferably water, is added add. 100 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • Another Aspect is directed to the use of a liquid alkaline composition obtained from the solid alkaline composition for use according to the invention to irreversibly detroy infectivity and/or to reduce unconventional infectious agents as required by national authorities, as for instance the Robert Koch Institute (RKI) or the internally National de Securite du Medicaments et de wall de sante (ANSM),
  • cleaning compositions according to the invention can take the form of a single concentrate or multiple concentrates that can be diluted and combined to provide a ready-to-use solution, and as a ready-to-use liquid composition that can be used to clean articles having a metal or plastic surface, such as surgical, medical, and dental instruments, including endoscopes and to irreversibly destroy and/or to reduce unconventional infectious agents as required National guidelines, as for instance from the Robert Koch Institute (RKI) or the erson National de Securite du
  • the solution can be in the form of a concentrate that can be diluted with a solvent, such as water, to provide a ready-to-use solution that can be used for cleaning and to irreversibly destroy infectivity and/or to reduce unconventional infectious agents applied to articles having a metal or plastic surface, such as surgical, medical, and dental instruments.
  • a solvent such as water
  • the solutions can be provided as a relatively dilute solution that can be, without the addition of water, to provide an organic ready-to use solution, for example an alcohol based ready-to use solution, that can be for cleaning and for inactivating and/or reducing unconventional infectious agents applied to articles having a metal surface, such as surgical, medical, and dental instruments.
  • an organic ready-to use solution for example an alcohol based ready-to use solution, that can be for cleaning and for inactivating and/or reducing unconventional infectious agents applied to articles having a metal surface, such as surgical, medical, and dental instruments.
  • the concentrate liquid composition and/or the ready-to-use solution can be used to irreversibly detroy infectivity and/or to reduce unconventional infectious agents according to the invention in an automated washing process for cleaning and disinfection metal surfaces, in particular metal or plastic surfaces of surgical, medical, and dental instruments including endoscopes, from body fluids, such as blood, lipids, contrast agent and synovial fluids from joints adhere to the metal surface used during a procedure.
  • body fluids such as blood, lipids, contrast agent and synovial fluids from joints adhere to the metal surface used during a procedure.
  • the source of alkalinity and addition of the solvent, preferably water, are provided so that the concentrated, preferably aqueous, liquid composition of the solid alkaline composition for the use of inactivating and/or reducing unconventional infectious agents according to the present invention may have a pH in the range of about 12 pH to about 14 pH, preferably a pH in the range of about 12.5 pH to about 13.5 pH and more preferred a pH of about 13 pH.
  • the ratio of the solvent, preferably water, to solid, to provide a concentrated liquid composition for the use of inactivating and/or reducing unconventional infectious agents according to the present invention, preferably an aqueous solution, of the solid alkaline composition can be in the range of from about 200 : 1 to about 10 : 1, preferably about 100 : 1 to about 12 : 1, further preferred about 50 : 1 to about 15 : 1, also preferred about 40 : 1 to about 17 : 1 and in particular preferred about 30 : 1 to 20 : 1.
  • the alkaline concentrated liquid composition can comprise for the use of irreversibly destroying infectivity and/or reducing unconventional infectious agents:
  • a solvent preferably water, is added add 100 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • the solid alkaline composition can comprise for the use of irreversibly destroying infectivity and/or reducing unconventional infectious agents:
  • - about > 0.01 wt.-% to about ⁇ 1 wt.-%, preferably about > 0.03 wt.-% to about ⁇ 0.75 wt.-%, further preferred about > 0.08 wt.-% to about ⁇ 0.5 wt.-%, and more preferred about > 0.16 wt.-% to about ⁇ 0.3 wt.-%, of at least one corrosion inhibitor, preferably the corrosion inhibitor is a heterocyclic compound and more preferred a benzotriazol;
  • the threshold inhibitor/crystal modifier is a salt of a polyacrylic acid
  • a solvent preferably water, is added add 100 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • the source of alkalinity and addition of solvent, preferably water, are provided so that the aqueous ready-to-use solution of the solid alkaline composition for use according to the present invention may have a pH in the range of about > 10 pH to about ⁇ 11.5 pH and preferably a pH in the range of about > 10.0 pH to about ⁇ 11.0 pH.
  • the ratio of the solvent, preferably water, to solid, to provide a ready-to-use solution, preferably an aqueous solution, of the solid alkaline composition for use according to the invention can be in the range of from about 10,000 : 1 to about 100 : 1, preferably about 5,000 : 1 to about 300 : 1, further preferred about 3,000 : 1 to about 500 : 1, also preferred about 2,500 : 1 to about 750 : 1 and in particular preferred about 2,000 : 1 to about 1,000 : 1.
  • the ready-to-use solution can comprise:
  • a solvent preferably water, is added add 100 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • the ready-to-use solution can comprise:
  • the threshold inhibitor/crystal modifier is a salt of a polyacrylic acid
  • the sequestering agent is a salt of an amine containing carboxylic acid; and - a solvent, preferably water, is added add 100 wt.-%; wherein the weight-% of the components are based on the total weight of the composition.
  • the cleaning apparatus can be used to provide the concentrated solution or ready-to-use solution which can be used to irreversibly destroy infectivity and/or to reduce unconventional infectious agents, such as prions, on surfaces, such as surgical, medical, and dental instruments that are potentially contaminated therewith.
  • the cleaning apparatus includes at least a first tank to receive the solid alkaline composition of the invention; at least a second component tank to receive water diluted concentrated composition or a ready-to-use solution of said solid alkaline composition of the invention, a water feed, and a use solution line; and optional a third component tank to receive a day portion of the concentrated composition or a ready-to-use solution of the invention.
  • the first component tank is provided for containing the solid alkaline composition of the invention.
  • the first component tank can be provided for mixing water to the solid alkaline
  • the solid alkaline composition can be mixed with water in a circulation method to obtain a defined alkaline aqueous concentrated liquid composition.
  • the second component tank is provided for receiving the aqueous concentrated liquid composition or for mixing water to the alkaline aqueous concentrated liquid composition to provide an alkaline ready-to-use solution.
  • the optional third component tank is provided for receiving a day portion of the aqueous concentrated liquid composition or for mixing water to the alkaline aqueous concentrated liquid composition to provide a day portion of an alkaline ready-to-use solution.
  • the water feed is provided for conveying water to the first tank, second tank (makeup tank) and/or third tank (day tank) for dissolving the solid alkaline composition (first tank) and/or for providing an aqueous concentrated alkaline liquid composition or alkaline ready-to-use solution (second tank) and/or for providing an aqueous alkaline ready-to-use solution (third tank).
  • the aqueous concentrated alkaline liquid composition is transferred to the day tank, by the time the defined concentration, pH, volume and/or temperature is reached.
  • the makeup tank (second tank) and more preferred the third tank (day tank) can be used to receive and stock the alkaline aqueous concentrated liquid composition or the ready-to-use solution.
  • aqueous concentrated alkaline liquid composition can be conveyed from the second tank or a day tank (optional third tank) to a dispenser and the dispenser sprays out the ready-to-use solution at the place of operation in a defined concentration.
  • the solution line is provided for conveying solution from the second container to a use solution applicator.
  • the solid alkaline composition can be used in combination with a healthcare solid dispenser.
  • This dispenser sprays out the solid alkaline composition having the form of a capsule in a circulation method to a defined concentration.
  • This alkaline aqueous concentrated liquid composition is collected in a makeup tank and transferred to a day tank as soon as the concentration and referring conductivity has reached the defined level. From there the pumps of the washer disinfectors dose the cleaning alkaline aqueous concentrated liquid composition in the cleaning cycle of the reprocessing step.
  • the solid can be diluted to a 5% alkaline aqueous concentrated liquid composition in the dispenser.
  • the ready-to-use solution or the concentrated liquid composition for use according to the invention can be in any form including liquid, gel, paste and slurry.
  • the cleaning solutions i.e. ready-to-use solution and/or the concentrated liquid composition, are suitable to treat any metal or plastic surface contaminated with unconventional infectious agents, such as prions.
  • Exemplary contaminants include body fluids, such as blood, lipids and synovial fluids and chemical residues.
  • aqueous cleaning solutions that can be used according to the invention, i.e. the aqueous alkaline ready-to-use solution and/or the concentrated aqueous alkaline liquid composition, may be used at any temperature, including an elevated temperature of from about 30° C to about 70° C, preferably about 45° C to about 60° C and more preferred about 55° C. After contact with the cleaning solution, the solution is removed from the metal or plastic surface.
  • the contact time of the aqueous cleaning solution in an automated process, i.e. ready-to-use solution and/or the concentrated liquid composition, with the metal substrates will vary depending upon the degree of contamination but broadly will range of about > 5 minute to about ⁇ 60 minutes, with about > 10 minutes to about ⁇ 30 minutes being more typical and also preferred is about > 10 minutes to about ⁇ 20 minutes.
  • the contact time of the aqueous cleaning solution at about > 55° C to about ⁇ 70° C in an automated process, i.e. ready-to-use solution and/or the concentrated liquid composition, with the metal substrates may range of about > 5 minute to about ⁇ 60 minutes, with about > 10 minutes to about ⁇ 30 minutes being more typical and also preferred is about > 10 minutes to about ⁇ 20 minutes.
  • a cleaning apparatus that can be used according to the invention may comprise:
  • a second container comprising a concentrated liquid composition of the solid composition according to claim 12 or 14 having a pH of about > 12.5 to about ⁇ 13.5, preferably a pH of about 13;
  • a use solution line for conveying the use solution from the second container and/or third container to a use solution applicator and/or to the place of use.
  • the composition has a surprising cleaning efficacy due to none or practical none foam formation, if mixed with water, as sump solution or in the dispensing drawer and can be used according to the invention for irreversible destruction of infectivity and/or reducing
  • alkaline concentrates were provided in a solid form:
  • This test method provides a basis to assess the inactivating properties of the liquid alkaline cleaning composition against unconventional infectious agents.
  • Phase 0 in vitro test - Western Blot
  • Phase la + lb (mode of action): in vitro test - Western Blot of surface and suspension
  • Phase la + lb (additional strains): in vitro test - Western Blot
  • Phase 2 in vivo test - animal test with hamsters
  • aqueous alkaline ready-to-use solution is formed, wherein first a 5 percentage concentrated solution of examples El to El 4 by dissolving in deionized water is obtained each. The concentrated solution is than dissolved with deionized water to a 1 percentage aqueous alkaline ready-to-use solution.
  • BSE Bovine spongiform encephalopathy
  • Stainless steel wires (Stainless steel reference: 316) were artificially contaminated with 10% brain homogenates obtained from rodents at the ultimate stage of diseases caused by these different prion strains in these animals. Then, these wires were treated with the ready-to-use solutions of El to E14 for 10 minutes at 55° C. These sheets were rinsed once using water for 2 minutes at room temperature (23° C). In parallel, contaminated wires were not treated and kept at these previous defined conditions to be the untreated controls.
  • Brains of hamsters infected with the 263K strain, of mice infected with the C506M3 strain and of mice infected with the 6PB1 BSE strain were controlled after euthanasia at the PBS using a ribolysor.
  • Stainless steel wires length 5 mm; Steelex monofilament B Braun, 0 0.30 mm, ref G0094137 were artificially contaminasted with the prion strains. Forty wires were immersed for 1 hour in 100 ⁇ L ⁇ of each inoculums, prepared as described. These wires were then dried individualized flat for 16 hours under flow at room temperature. For the prescreening study (phase 0), only the 263K strain was evaluated).
  • Wires were desorbed using the methodology described above by Lemmer et al.. Supports were incubated in TBS - Sarkosyl (50 mM Tris-HCL, 150 mM NaCl pH 7.5, 1% Sarkosysl) buffer supplemented with 150 ⁇ g/ml of proteinase K for 1 hour at 37° C.
  • TBS - Sarkosyl 50 mM Tris-HCL, 150 mM NaCl pH 7.5, 1% Sarkosysl
  • desorption solutions were 1 :2 diluted in western blot buffer, concentrated twice, in final volume of 104 ⁇ .
  • PrPres 50% titres were determined usind the Spearman-Karber formula. The amount of PrPres coated on supports or in solution was then calculated by comparing the titre to the final volume of the samples generated after desorption and precipitation. The reduction factor (RF) for each treatment was calculated as follows:
  • the El to El 4 ready to use compositions significantly reduce the risk associated with prions and reusable medical devices such as surgical stainless steel.
  • composition of the invention To measure the efficiency of the composition of the invention to eliminate and/or to inactivate the 263K scrapie strain invivo.
  • This bioassay was the animal model of Syrien Golden hamsters infected with the scrapie 263K strain accordance with the general principles enunciated in the "Prion Standard Protocol” (PSP) of the "Ann Nationale da Securite du Medicament et des wall de sante” (ANSM; formerly “Ann Franchise de Securite Sanitaire des Produits de Sante” (Afssaps)).
  • PSP Primary Standard Protocol
  • Stainless steel wire segments (Aesculap", 5 mm x 0.30 mm) were artificially contaminated by incubation in a suspension containing a known load of TSE (strain 263K). After drying, they were treated with 3 different decontamination procedures under study
  • Example E8 efficiently reduced the infectious load on wire, with a RF > 5.5 and a transmission rate of 0%, their efficiencies are considered as "Complete”. Animals
  • Negative controls were composed of 3 hamsters in 3 groups. Among them, two hamsters were not implanted (NN) and the others were implanted with wires coated with negative brain homogenate treated or not with E8 product (NW group for untreated wires and NT2W and group for E8 product).
  • Standard curve and positive control groups Standard curves were composed of 1 of 8 hamsters for the highest dilution, 2 groups of 4 hamsters for the two following dilutions, 4 groups of 8 hamsters for the next four dilutions, and 2 groups of 4 hamsters for the last two dilutions (SCIW toSC9W sub-groups).
  • the SCIW group corresponded also to the untreated or positive group (PCW). For each group, 12 steel wires were contaminated by respective incubations in serially 10-fold dilutions of positive homogenate.
  • the hamsters were housed in the biosafety level 2 animal facilities (INRA Centre de Ours, Plate-forme d'lnfectiologie Experimentale, 37380 Nouzilly, France). Animals were stabilized one week and identified by an electronic tag before starting the experiments. Food (Rodent food RMl from SDS) and drink (Tap water) was ad libitum.
  • Wires were contaminated using 10% brain homogenates obtained from 263K-infected hamsters at the terminal stage of TSE disease.
  • Brain homogenates were previously obtained from brains of 263K-infected hamsters at the terminal stage of the disease. These brains were homogenized using a ribolyser, at 20% weight/volume (w/v) in a sterile 5% glucose solution.
  • the unconventional transmissible agent 263K strain is used in our laboratory for validation purpose of inactivation/elimination process. This TSE strain was manipulated in CEA Level-2 high-security facilities.
  • the 263K strain is a laboratory scrapie strain with a titre of 10 11 infectious units per gram of brain. It was selected and propagated in the Syrian golden hamster in which it had been stabilized. The model of infection of the hamster by strain 263K yields quick results. The average period of incubation is 70 days and death occurs between 80 and 90 days for an intracerebral injection of 10 infectious units.
  • Stainless-steel wires were artificially contaminated with the 263K strain by an incubation of 1 hour under gentle agitation in the 263K-infected brain homogenate previously described in the section "Strain of Transmissible Spongiform Encephalopathy agent" above. These stainless-steel wires were dried for 16 hours under a class II microbiological safety cabinet at ambient temperature (23° C).
  • the anaesthetized animals were implanted intracerebral with an individual wire.
  • the infectious titre was determined on the basis of the physical examination, the dates of death, and observation of the terminal stage.
  • the physical examination included observation of the pathognomonic signs of transmissible sub acute spongiform encephalopathy.
  • the physical examinations were practiced once or twice a week along the study. There are four types physical signs:
  • Paraplegia then tetraplegia. Undings were examination.
  • Brain homogenates from hamsters were homogenized using a ribolyser at 20% weight/volume (w/v) in a sterile 5% glucose solution. PrPres was then purified from these brain homogenates using the Biorad's "BSE purification kit" according to the Bertin Pharma's in-house methodology. All these samples were run on 12 % polyacrylamide gels and transferred onto a nitrocellulose membrane. Immunoblotting was performed with the monoclonal peroxidase-conjugated anti-mouse PrP Sha-31 antibody. Immuno-reactivity was revealed using ECL hyperfilm (Amersham) and the "Super Signal R-West Extended Duration Substrate” (Pierce), visualized by autoradiography.
  • ID50 50% infectious dose
  • M logarithm (loglO) of the dilution at which half the mice are infected, relative to the tested volume
  • X k is the log 10 of the highest dilution with the 100 % of infected mice
  • d is the log 10 of the dilution factor
  • pi is the ratio between the number of infected mice per dilution and the number of inoculated mice per dilution
  • ⁇ p t is the sum of pi (starting with the highest dilution giving 100 % of positivity).
  • SE standard error
  • n is the number of mice inoculated at each dilution
  • r is the total number of mice infected counting all dilutions
  • rl , r2 are .. . the numbers of mice infected at each dilution.
  • the 95 % confidence interval is reported as: Mean ID50 ⁇ 1.96 SE.
  • the mean duration was calculated including both TSE infected and healthy animals sacrificed at the end of the study, to take into account these values both the incubation periods of TSE disease and the transmission rate.
  • the mean duration for different groups of the standard curve was plotted to define a 4- parameter standard curve.
  • the mean duration was reported on the curve to determine the dilution of adsorbed inoculums presenting an equivalent infectivity.
  • the RF related to each treatment was calculated as follows:
  • the 50% infectious dose (ID50) coated on each wire was of 5.5 ⁇ 0.7 log 10. It is of interest to note that this titre per wire is consistent with those previously described for this scrapie 263K strain.
  • composition of the invention E8 efficiently reduced the infectious load on wire. With a RF > 5.5 and a transmission rate of 0 its efficiency considered as "Complete" by PSP.
  • This test method provides a basis to assess the foam formation properties of the liquid alkaline cleaning composition of the invention.
  • aqueous alkaline ready-to-use solution is formed, wherein 1.0 g of examples 1 to 14 and VI to V7 are dissolved in 100 ml of deionized water each.
  • the long-necked glass cylinder was then turned up and down 20 x times in 20 seconds.
  • the foam hight of about > 0 ml and about ⁇ 0.1 ml are considered to be excellent (++) and in line with the invention.
  • the foam hight of about > 0.1 ml to about ⁇ 5 ml are considered to be good (+) and in line with the invention.
  • the foam hight of about > 5 ml are considered to be insufficient (-) thus not in line with the invention, i.e. non-inventive.
  • the table 12 shows the result of the foam formation caused by the aqueous alkaline ready-to- use solution of examples El to E14 and VI to V7 obtained by the foam formation test.
  • This test method provides a basis to assess the enhanced metal-surface-safeness of the liquid alkaline cleaning composition with respect to corrosion.
  • the cleaning compositions El to E14 were diluted with deionized water to a 0.8 wt.-% ready- to-use solution.
  • the weights of aluminum test plates of 100 mm x 50 mm x 1.5 mm were recorded and then placed in the center area of the bottom of a 350 ml wide -necked screw cap flask each. The aluminum test plates were completely submerged. Subsequently, each wide -necked screw cap flask was filed to the top with said 0.8 wt.-% ready-to-use solution El to E14 having a temperature of 23° C. The wide -necked screw cap flasks were closed with the cap and allow staying for 7 days at a temperature of 23° C.
  • the aluminum test plates were removed, rinsed with deionized water, placed on a clean paper towel and allowed to dry at a temperature of 23° C. The aluminum test plates were then weighted and the weight was taken to the fourth place. Subsequently the aluminum test plates were returned in there wide-necked screw cap flasks for another 7 days. Thereafter, the aluminum test plates were removed, rinsed with deionized water, placed on a clean paper towel and allowed to dry at a temperature of 23° C. The aluminum test plates were then weighted and the weight was taken to the fourth place. Subsequently the aluminum test plates were returned again in there wide -necked screw cap flasks for another 7 days. The weight loss was calculated. Three tests were run for each experiment and the average weight loss was determined. The average weight loss for each aluminum test plates after treatment with said ready-to-use solution obtained from El to El 4 were about ⁇ 0.34 wt.-%.
  • Metal surfaces and/or plastic surfaces in need of cleaning are found in several locations.
  • Exemplary locations include surgical instruments, medical instruments, and dental instruments, sinks, cookware, utensils, machine parts, vehicles, tanker trucks, vehicle wheels, work surfaces, tanks, immersion vessels, spray washers, and ultrasonic baths.
  • compositions can be used for inactivating and/or reducing unconventional infectious agents, such as prions and for removing residues including blood, greases, cutting fluids, drawing fluids, machine oils, antirust oils such as cosmoline, carbonaceous soils, sebaceous soils, particulate matter, waxes, paraffins, used motor oil, fuels, etc..
  • unconventional infectious agents such as prions and for removing residues including blood, greases, cutting fluids, drawing fluids, machine oils, antirust oils such as cosmoline, carbonaceous soils, sebaceous soils, particulate matter, waxes, paraffins, used motor oil, fuels, etc.
  • Metal surfaces that can be treated with the composition for inactivating and/or reducing unconventional infectious agents, such as prions include iron-based metals such as iron, iron alloys, e. g. steel, tin, aluminum, copper, tungsten, titanium, molybdenum, etc., for example.
  • iron-based metals such as iron, iron alloys, e. g. steel, tin, aluminum, copper, tungsten, titanium, molybdenum, etc., for example.
  • the metal surface and/or plastic surface can be as a metal and/or plastic part of complex configuration, sheeting, coils, rolls, bars, rods, plates, disks, etc..
  • liquid alkaline solution in particular the ready-to-use-solution on metal and/or plastic articles, especially metal instruments, plastic instruments, instruments with a plastic surface and/or instruments with a metal surface for inactivating and/or reducing unconventional infectious agents, such as prions, thereon.
  • liquid alkaline cleaning solution in particular the ready-to-use- solution
  • an automated instrument processing metal and/or plastic articles especially metal instruments, plastic instruments, instruments with a plastic surface and/or instruments with a metal surface for inactivating and/or reducing unconventional infectious agents, such as prions, thereon.
  • the term “about” refers to variation in the numerical quantity that can occur, for example, through typical measuring and liquid handling procedures used for making concentrates or use solutions in the real world; through inadvertent error in these procedures; through differences in the manufacture, source, or purity of the ingredients used to make the compositions or carry out the methods; and the like.
  • the term “about” also encompasses amounts that differ due to different equilibrium conditions for a composition resulting from a particular initial mixture. Whether or not modified by the term “about”, the claims include equivalents to the quantities.
  • composition containing "a compound” includes a mixture of two or more compounds.
  • the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention concerne l'utilisation d'une composition alcaline solide pour nettoyer et/ou détruire des prions sur des surfaces contaminées par des agents infectieux inhabituels, comprenant au moins une source alcaline, au moins un polyéthylène glycol et facultativement au moins un inhibiteur de corrosion, le rapport entre la source alcaline et le polyéthylène glycol étant dans la plage entre environ 30:1 et environ 2:1.
PCT/EP2013/071536 2013-10-15 2013-10-15 Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces WO2015055234A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/071536 WO2015055234A1 (fr) 2013-10-15 2013-10-15 Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/071536 WO2015055234A1 (fr) 2013-10-15 2013-10-15 Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces

Publications (1)

Publication Number Publication Date
WO2015055234A1 true WO2015055234A1 (fr) 2015-04-23

Family

ID=49354689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/071536 WO2015055234A1 (fr) 2013-10-15 2013-10-15 Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces

Country Status (1)

Country Link
WO (1) WO2015055234A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106757094A (zh) * 2016-12-07 2017-05-31 江西瑞思博化工有限公司 铝质手机电池盖洗白剂及其制备方法
US10450534B2 (en) 2016-07-19 2019-10-22 Ecolab Usa Inc. Methods and cleaning solutions for removing chewing gum and other sticky food substances
US10751762B2 (en) 2016-07-15 2020-08-25 Ecolab Usa Inc. Aluminum safe degreasing and pre-soak technology for bakery and deli wares and use thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020105A1 (fr) * 1996-11-01 1998-05-14 The Procter & Gamble Company Compositions detergentes en granules pour la lessive ne contenant pratiquement pas d'adjuvants a base de phosphates ou d'aluminosilicates
US6194368B1 (en) * 1995-07-13 2001-02-27 Joh A. Benckiser, Gmbh Dishwasher product in tablet form
US6221820B1 (en) * 1997-12-31 2001-04-24 Henkel Kommanditgesellschaft Auf Aktien Granular component containing alkylaminotriazole for use in machine dishwashing detergents
WO2002002725A1 (fr) * 2000-06-30 2002-01-10 The Procter & Gamble Company Compositions detergentes comprenant une enzyme cyclodextrine glucanotransferase
WO2004085596A1 (fr) * 2003-03-25 2004-10-07 Henkel Kommanditgesellschaft Auf Aktien Produit de lavage ou de nettoyage
WO2008020234A2 (fr) * 2006-08-18 2008-02-21 Reckitt Benckiser N. V. Composition de détergent
US20080096784A1 (en) * 2006-05-15 2008-04-24 Voco Gmbh Composition for Cleaning Dental Instruments and Process
US20080131503A1 (en) * 2005-02-10 2008-06-05 Per Holm Stable Pharmaceutical Composition Comprising a Fixed Dose Combination of Fenofibrate and an Hmg-Coa Reductase Inhibitor
WO2012045365A1 (fr) * 2010-10-08 2012-04-12 Ecolab Inc. Efficacité de nettoyage d'une matière solide sans danger pour les métaux pour le traitement automatisé d'instruments

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194368B1 (en) * 1995-07-13 2001-02-27 Joh A. Benckiser, Gmbh Dishwasher product in tablet form
WO1998020105A1 (fr) * 1996-11-01 1998-05-14 The Procter & Gamble Company Compositions detergentes en granules pour la lessive ne contenant pratiquement pas d'adjuvants a base de phosphates ou d'aluminosilicates
US6221820B1 (en) * 1997-12-31 2001-04-24 Henkel Kommanditgesellschaft Auf Aktien Granular component containing alkylaminotriazole for use in machine dishwashing detergents
WO2002002725A1 (fr) * 2000-06-30 2002-01-10 The Procter & Gamble Company Compositions detergentes comprenant une enzyme cyclodextrine glucanotransferase
WO2004085596A1 (fr) * 2003-03-25 2004-10-07 Henkel Kommanditgesellschaft Auf Aktien Produit de lavage ou de nettoyage
US20080131503A1 (en) * 2005-02-10 2008-06-05 Per Holm Stable Pharmaceutical Composition Comprising a Fixed Dose Combination of Fenofibrate and an Hmg-Coa Reductase Inhibitor
US20080096784A1 (en) * 2006-05-15 2008-04-24 Voco Gmbh Composition for Cleaning Dental Instruments and Process
WO2008020234A2 (fr) * 2006-08-18 2008-02-21 Reckitt Benckiser N. V. Composition de détergent
WO2012045365A1 (fr) * 2010-10-08 2012-04-12 Ecolab Inc. Efficacité de nettoyage d'une matière solide sans danger pour les métaux pour le traitement automatisé d'instruments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEMMER ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 85, no. 12, December 2004 (2004-12-01), pages 3805 - 3816
WADSWORTH ET AL., THE LANCET, vol. 358, no. 9277, 21 July 2001 (2001-07-21), pages 171 - 180

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10751762B2 (en) 2016-07-15 2020-08-25 Ecolab Usa Inc. Aluminum safe degreasing and pre-soak technology for bakery and deli wares and use thereof
US11383277B2 (en) 2016-07-15 2022-07-12 Ecolab Usa Inc. Aluminum safe degreasing and pre-soak technology for bakery and deli wares and use thereof
US10450534B2 (en) 2016-07-19 2019-10-22 Ecolab Usa Inc. Methods and cleaning solutions for removing chewing gum and other sticky food substances
US10689602B2 (en) 2016-07-19 2020-06-23 Ecolab Usa Inc. Methods and cleaning solutions for removing chewing gum and other sticky food substances
CN106757094A (zh) * 2016-12-07 2017-05-31 江西瑞思博化工有限公司 铝质手机电池盖洗白剂及其制备方法

Similar Documents

Publication Publication Date Title
ES2294199T3 (es) Descontaminacion de superficies contaminadas con material infectado con priones con formulaciones basadas en agente oxidante.
EP1628689B1 (fr) Formule de nettoyage et de decontamination pour surfaces contaminees par un materiau infecte par les prions
ES2394840T3 (es) Desinfección a máquina de objetos
WO2015055234A1 (fr) Utilisation d'un solide actif pour nettoyer et inactiver des agents infectieux inhabituels sur des surfaces
JP4244190B2 (ja) 外科用および医療用の機器および器具の洗浄並びに消毒
JP2010525886A5 (fr)
EP2625257B1 (fr) Efficacité de nettoyage d'une matière solide sans danger pour les métaux pour le traitement automatisé d'instruments
US20070286907A1 (en) Germicide composition
EP3022280B1 (fr) Nettoyeur d'instrument solide à alcalinité moyenne
EP2240208A1 (fr) Formulation destinée à une large gamme de désinfections, incluant la décontamination en cas de contamination par des prions
EP2609185B1 (fr) Nettoyant liquide pour traitement automatisé
JP4130378B2 (ja) 医療機器用殺菌洗浄剤
JPH04135559A (ja) 人工透析の医療機器の消毒洗浄剤
Kelland et al. Martin MIELKE Prion Disinfectant
JP2008246099A (ja) 濾過器の洗浄方法、及び、循環式浴槽の除菌洗浄方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13776517

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13776517

Country of ref document: EP

Kind code of ref document: A1